Search Our Scientific Publications & Authors

J Korean Assoc Oral Maxillofac Surg 2022 Apr;48(2):85-93

Department of Oral and Maxillofacial Radiology, Dental Implants Research Center, and Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.

Objectives: The aim of this study was to compare morbidities and duration of surgery, as well as bone formation in alveolar defects reconstructed with symphysis bone combined with allograft and iliac crest bone graft in patients with cleft palate. Patients and.

Methods: This randomized clinical trial was performed with 22 patients with unilateral alveolar cleft with a follow-up period of 12 months. Read More

Chin J Traumatol 2022 Apr 5. Epub 2022 Apr 5.

Department of Traumatic Orthopaedics, The Medical College of Ningbo University Affiliated Ningbo No. 6 Hospital, Ningbo, 315040, Zhejiang Province, China.

Purpose: To compare the stability of the posterior anatomic self-locking plate (PASP) with two types of popular reconstruction plate fixation, i.e. double reconstruction plate (DRP) and cross reconstruction plate (CRP), and to explore the influence of sitting and turning right/left on implants. Read More

Membranes (Basel) 2022 Mar 25;12(4). Epub 2022 Mar 25.

School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Drive, Singapore 637553, Singapore.

Functional biointerfaces hold broad significance for designing cell-responsive medical implants and sensor devices. Solid-supported phospholipid bilayers are a promising class of biological materials to build bioinspired thin-film coatings, as they can facilitate interactions with cell membranes. However, it remains challenging to fabricate lipid bilayers on medically relevant materials such as titanium oxide surfaces. Read More

Front Surg 2022 25;9:815106. Epub 2022 Mar 25.

Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR, China.

Background: Chin implants have a long history, and its usage may be associated with mandibular bone resorption.

Objectives: This report analyzed data on this topic from existing literature to evaluate the overall resorption rate and scientific impact in terms of citations.

Method: PubMed, Web of Science, Scopus, and Google Scholar databases were searched to identify relevant publications. Read More

Bioact Mater 2022 Dec 26;18:199-212. Epub 2022 Mar 26.

Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, and Department of Orthopedic Surgery of Sir Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, PR China.

Although ultra-small nanoclusters (USNCs, < 2 nm) have immense application capabilities in biomedicine, the investigation on body-wide organ responses towards USNCs is scant. Here, applying a novel strategy of single-cell mass cytometry combined with Nano Genome Atlas of multi-tissues, we systematically evaluate the interactions between the host and calcium phosphate (CaP) USNCs at the organism level. Combining single-cell mass cytometry, and magnetic luminex assay results, we identify dynamic immune responses to CaP USNCs at the single cell resolution. Read More

Clin Plast Surg 2022 Apr;49(2):275-283

Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, 170 Commonwealth Avenue, Boston, MA 02116, USA. Electronic address: https://twitter.com/%20DrYaremchuk.

The size and shape of the chin and mandible are fundamental to sexual dimorphism. Deficiencies in these structures distract from the male facial esthetic. When deficient, these areas of the facial skeleton can be augmented by alloplastic augmentation or skeletal rearrangement. Read More

Brachytherapy 2022 Mar 22. Epub 2022 Mar 22.

Baines Imaging Research Laboratory, London, Ontario, Canada; Lawson Health Research Institute, London, Ontario, Canada; Department of Medical Biophysics, Western University, London, Ontario, Canada; Department of Oncology, Western University, London, Ontario, Canada; London Regional Cancer Program, London, Ontario, Canada. Electronic address:

Purpose: Multiparametric magnetic resonance imaging (mpMRI) has demonstrated the ability to localize intraprostatic lesions. It is our goal to determine how to optimally target the underlying histopathological cancer within the setting of high-dose-rate brachytherapy (HDR-BT).

Methods And Materials: Ten prostatectomy patients had pathologist-annotated mid-gland histology registered to pre-procedural mpMRI, which were interpreted by four different observers. Read More

J Chin Med Assoc 2022 05 2;85(5):543-548. Epub 2022 May 2.

Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Background: The results of the recent Amsterdam Investigator-Initiated Absorb Strategy All-Comers trial showed that the predilatation, sizing, and postdilatation (PSP) technique did not lower the long-term rates of scaffold thrombosis and adverse events. We evaluated the impact of aggressive PSP bioresorbable vascular scaffold (BRS) implantation on the short- and long-term clinical outcomes.

Methods: From June 2014 to December 2016, 150 patients with BRS implantation were enrolled and received successful percutaneous coronary intervention (PCI), of whom 104 received aggressive PSP technique (high-pressure predilatation and lesion preparation in addition to the traditional PSP technique). Read More

J Chin Med Assoc 2022 Apr;85(4):478-483

Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC.

Background: It is unclear whether neural response telemetric (NRT) thresholds are related to lexical tonal language performance after cochlear implants (CIs). We explored the factors associated with changes in NRT thresholds and postoperative performance of CI patients.

Methods: Patients receiving nucleus 24 CIs in our hospital from November 2010 were enrolled. Read More

Oral Oncol 2022 Apr 4;127:105800. Epub 2022 Mar 4.

Department of Oncologic and Reconstructive Surgery, Maria Sklodowska-Curie National Research Institute of Oncology, Poland.

Introduction: Post- resection defects in the area of the head and neck frequently result in functional impairment of the masticatory system and unaesthetic outcome in the facial appearance. In pediatric population they exert a devastating effect on speech development, breathing and facial growth leading to secondary deformations which are extremely challenging in reconstruction by means of conventional surgery protocols.

Material And Methods: 21 patients (14 males/ 7 females) aged 4-17 years old, treated between 2015 and 2019 due to malignant/benign tumors or congenital deformities requiring mandible resection were enrolled in the study. Read More

Chin Med 2022 Feb 21;17(1):26. Epub 2022 Feb 21.

Clinical Research Center, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, 201800, China.

Background: Microarc oxidation (MAO) on the surface of medical pure titanium can improve its histocompatibility, and loading drugs on the surface can resist excessive intimal hyperplasia.

Methods: In this study, salidroside (SAL) was loaded on the surface of porous titanium (Ti) with polydopamine (PDA) carrier. The effects of SAL on the osteogenesis and angiogenesis of Ti implants were studied by phalloidin staining, alizarin red staining, ALP staining, wound-healing assay, cell transwell assay, matrigel tube formation, and osteogenic and angiogenic genes and proteins expression detected by PCR and western blot in vitro. Read More

Plast Reconstr Surg 2022 Feb;149(2):324-337

From the Department of Plastic Surgery and the Nightingale Centre, Manchester University Hospitals NHS Foundation Trust, Wythenshawe Hospital; Bristol Centre for Surgical Research, Population Health Sciences, Bristol Medical School; University of Manchester, Manchester Academic Health Science Centre; and Bristol Breast Care Centre, North Bristol NHS Trust, Southmead Hospital.

Background: Breast augmentation is the most commonly performed cosmetic procedure, and increasingly women in this group present with breast cancer or request risk-reducing surgery, but their optimal management is unclear. The authors explored the clinical and patient-reported outcomes of patients undergoing immediate implant-based breast reconstruction following previous augmentation and compared these with outcomes of patients who had not had cosmetic implants in the Implant Breast Reconstruction Evaluation (iBRA) Study.

Methods: Patients undergoing immediate implant-based breast reconstruction were prospectively recruited from breast and plastic surgical units across the United Kingdom. Read More

Int J Comput Dent 2022 Jan 24;0(0). Epub 2022 Jan 24.

Aim: We conducted a prospective study to evaluate the accuracy and complications of 3D-printed patient-specific surgical guides and plates that were designed and finished in-house.

Materials And Methods: Eighteen patients who required advancement genioplasty, with or without concomitant orthognathic surgery, were enrolled in the study. Virtual surgical movements were simulated using the patients' cone-beam computed tomography (CBCT) scans, and computer-aided designing of patient-specific surgical guides and fixation plates were performed in our department. Read More

Chin J Dent Res 2021 12;24(4):257-265

Objective: To investigate the time efficiency of prefabricated prostheses located by an anchor pin stereolithographic attachment system for immediate loading implant reconstruction of completely edentulous jaws and compare it with the conventional protocol.

Methods: Edentulous patients were recruited and randomly assigned into two groups: the full digital workflow group (digital group) and the conventional workflow group (conventional group). In the digital group, a provisional prosthesis was fabricated before surgery using a fully digital workflow and delivered immediately after implant placement. Read More

Chin J Dent Res 2021 12;24(4):251-256

Objective: To assess bone volume stability and identify critical bone graft thickness for guided bone regeneration (GBR) simultaneous to implant placement in the maxillary anterior region.

Methods: Eighteen patients were included in the study and received placement of one maxillary anterior implant combined with GBR using deproteinised bovine bone mineral (DBBM) and resorbable collagen membrane. The multilevel buccal bone thickness (BT) was measured by CBCT 1 to 2 weeks and 5 to 8 months post-implantation (at implant uncovering surgery). Read More

Sensors (Basel) 2021 Nov 29;21(23). Epub 2021 Nov 29.

Department of Biomaterials, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

Three-dimensional reconstruction plays a vital role in assisting doctors and surgeons in diagnosing the healing progress of bone defects. Common three-dimensional reconstruction methods include surface and volume rendering. As the focus is on the shape of the bone, this study omits the volume rendering methods. Read More

Zhonghua Yan Ke Za Zhi 2021 Sep;57(9):679-684

The First Affiliated Hospital of Fujian Medical University, Fujian Institute of Ophthalmology, Fuzhou 350004, China.

To evaluate the efficacy and safety of the XEN gel implant in the treatment of glaucoma. It was a retrospective case series study. Eight patients (8 eyes) in the First Affiliated Hospital of Fujian Medical University from January 2020 to September 2020 were included, including six males and two females, aged 29 to 74 years. Read More

Chin Med 2021 Dec 4;16(1):131. Epub 2021 Dec 4.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Macau SAR, China.

Background: Implantation of a biomaterial may induce the foreign-body reaction to the host tissue that determines the outcome of the integration and the biological performance of the implants. The foreign-body reaction can be modulated by control of the material properties of the implants.

Methods: First, we synthesized methacrylated Bletilla striata Polysaccharide (BSP-MA) and constructed a series of open porous cryogels utilizing this material via the freezing-thawing treatment of solvent-precursors systems. Read More

J Craniofac Surg 2021 Jun;32(4):e389-e392

iWELL Plastic Surgery Clinic, Seoul, Republic of Korea.

Abstract: Advancement genioplasty is performed to aesthetically improve the lower third of the facial profile. Excessive chin advancement alone may lead to deepened labiomental sulcus and deformed aesthetic results. The purpose of this study was to assess the efficacy of silicone prosthesis placement as an alternative method for effacing an excessively deepened labiomental groove after advancement genioplasty. Read More

Chin Med J (Engl) 2021 Oct 14;134(21):2597-2602. Epub 2021 Oct 14.

Department of Orthopedic Oncology Surgery, Beijing Ji Shui Tan Hospital, Peking University, Beijing 100035, China.

Background: Computed tomography (CT) and magnetic resonance imaging (MRI) data can be fused to identify the tumor boundaries. This enables surgeons to set close but tumor-free surgical margins and excise the tumor more precisely. This study aimed to report our experience in performing computer navigation-aided joint-preserving resection and custom-made endoprosthesis reconstruction to treat bone sarcoma in the diaphysis and metaphysis of the femur and tibia. Read More

Biomaterials 2021 11 9;278:121177. Epub 2021 Oct 9.

Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China; Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Hangzhou, China; China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, China. Electronic address:

Although biomaterials are widely utilized in clinics, it still follows the "one-fits-all" strategy. Biological variables such as age and sexuality have an impact on the host immune response and are not fully considered in the practice guidelines of the biomaterial implantation. In this study, we investigated the immuno-material interactions of six commonly used biomaterials (agarose, alginate, chitosan, CMC, GelMA and collagen type I) and constructed a population (with different ages and sexes) based transcriptome atlas. Read More

Anat Cell Biol 2021 Dec;54(4):409-416

Department of Neurosurgery, Tulane Center for Clinical Neurosciences, Tulane University School of Medicine, New Orleans, LA, USA.

The incisive branch of the inferior alveolar nerve is a vital anatomical structure within the anterior mandible that has not been thoroughly defined and outlined in reports in the literature until recent years. Advances in radiological imaging, particularly the widespread use of cone-beam computed tomography has allowed for accurate visualization of the mandibular incisive canal (MIC) and its associated incisive branch of the inferior alveolar nerve. Surgical damage to the MIC, which could result in hemorrhage and sensory disturbance, may occur in commonly practiced oral and maxillofacial procedures, such as chin bone harvesting, implant placement, fracture repair and removal of pathologic entities of the anterior mandible. Read More

Zhonghua Yan Ke Za Zhi 2021 Oct;57(10):727-733

An artificial corneal transplant (keratoprosthesis, KPro) is the only procedure to restore sight for patients with end-stage corneal blindness after multiple failed corneal transplants, severe eye burns, autoimmune-related and cicatricial keratoconjunctival diseases. At present, the representative KPros are Boston KPros and Russian MICOF KPros. They have been used for patients worldwide for nearly 30 years, and the success rate in two years after surgery reaches up to 85%. Read More

Cureus 2021 Aug 26;13(8):e17457. Epub 2021 Aug 26.

Faculty of Science and Sports, University of Technology, Kingston, JAM.

Introduction Anterior cervical discectomy and fusion (ACDF) is the gold standard for the treatment of cervical spondylosis. However, new techniques, technologies, and improved implants have aided surgeons in reducing operative time with enhanced patient outcomes. Impregnated hydroxyapatite polyetheretherketone (HA PEEK) cages (Arena-C HA®, LESspine Inc. Read More

Chin J Traumatol 2021 Sep 14. Epub 2021 Sep 14.

Department of Orthopaedics, Jay Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences, New Delhi, India.

Intracapsular fractures of the proximal femur are one of the most common fractures of the lower limbs. Most cases require osteosynthesis with suitable implants, and intraoperative positioning of the patient on the fracture table is a prerequisite to facilitate fracture manipulation, traction, reduction and fluoroscopy assessment. However, positioning the limbs of bilateral above-knee amputees for internal fixation of related proximal femoral fractures is a difficult task, which require customized inventory for effective limb positioning and fracture manipulation. Read More

J Chin Med Assoc 2021 11;84(11):1038-1047

Department of Biomedical Engineering, Hungkuang University, Taichung, Taiwan, ROC.

Background: Medial displacement calcaneal osteotomy (MDCO) is frequently used for the surgical correction of flatfoot. This study aims to investigate the biomechanical effect of the different diagonal screw design on a novel-designed embedded calcaneal plate for MDCO using finite element analysis (FEA), mechanical test and digital image correlation (DIC) measurement.

Methods: Four groups according to the varied implanted plate were set as control group (Group 1), non-diagonal screw (Group 2), one-diagonal screw (Group 3), and two-diagonal screws groups (Group 4). Read More

Chin J Traumatol 2022 May 2;25(3):125-131. Epub 2021 Sep 2.

Center for Joint Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China. Electronic address:

Joint arthroplasty is an effective method for treating end-stage joint lesions and damages. Robotic arm-assisted arthroplasty, a rapidly developing technology that combines navigation technology, minimally invasive technology, and precise control technology of the robotic arm, can achieve accurate preoperative planning, optimal selection of implants, minimally invasive surgery, precise osteotomy, and accurate placement of the artificial joint. It has the characteristics of high accuracy and stability, and thus is more and more widely used in the field of joint surgery. Read More

Facial Plast Surg 2021 Dec 16;37(6):709-715. Epub 2021 Sep 16.

Otolaryngology and Facial Plastic Associates, Fort Worth, Texas.

Genioplasty is a useful technique employed for both aesthetic and, in the case of obstructive sleep apnea, functional purposes. Mandibular implants similarly represent a powerful tool in the facial surgeons armamentarium. Herein, we review relevant anatomy, patient evaluation, and various techniques employing both alloplastic augmentation and osseous modification of the mandible. Read More

Nat Commun 2021 08 26;12(1):5138. Epub 2021 Aug 26.

Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.

Immune checkpoint blockade antibodies have promising clinical applications but suffer from disadvantages such as severe toxicities and moderate patient-response rates. None of the current delivery strategies, including local administration aiming to avoid systemic toxicities, can sustainably supply drugs over the course of weeks; adjustment of drug dose, either to lower systemic toxicities or to augment therapeutic response, is not possible. Herein, we develop an implantable miniaturized device using electrode-embedded optical fibers with both local delivery and measurement capabilities over the course of a few weeks. Read More

Am J Orthod Dentofacial Orthop 2021 Dec 13;160(6):872-886. Epub 2021 Aug 13.

Beauty Forever Dental Clinic, Taipei, Taiwan.

A patient with mutilated dentition was treated to an acceptable result with the help of mini-implants for anchorage, autotransplantation of 2 teeth, one dental implant, and multiple prostheses. The major problems for this mutilated dentition were multiple missing teeth, bite collapse with posterior crossbites, deepbite with a canted gummy smile, and severe skeletal discrepancy of maxillary protrusion and mandibular retrusion. Mini-implant anchorage was applied to retract and intrude the maxillary arch to reduce the protrusion and rotate the mandible counterclockwise to improve the chin projection. Read More