11,580 results match your criteria Childs Nervous System[Journal]


Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR).

EMBO J 2020 Jul 9:e104730. Epub 2020 Jul 9.

Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA.

The chimeric antigen receptor (CAR) directs T cells to target and kill specific cancer cells. Despite the success of CAR T therapy in clinics, the intracellular signaling pathways that lead to CAR T cell activation remain unclear. Using CD19 CAR as a model, we report that, similar to the endogenous T cell receptor (TCR), antigen engagement triggers the formation of CAR microclusters that transduce downstream signaling. Read More

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http://dx.doi.org/10.15252/embj.2020104730DOI Listing

The selective dorsal rhizotomy technique for spasticity in 2020: a review.

Authors:
Rick Abbott

Childs Nerv Syst 2020 Jul 9. Epub 2020 Jul 9.

Albert Einstein College of Medicine, Montefiore Health System, 110 E. 210th St, Bronx, NY, 10467, USA.

This review looks at the advances in the surgical technique, selective dorsal rhizotomy, used for the management of spasticity in children. Read More

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http://dx.doi.org/10.1007/s00381-020-04765-6DOI Listing

Why are pediatric neurosurgeons not little adult neurosurgeons?

Authors:
Wolfgang Wagner

Childs Nerv Syst 2020 Jul 8. Epub 2020 Jul 8.

Section of Pediatric Neurosurgery, University Medical Center, Langenbeckstr. 1, 55131, Mainz, Germany.

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http://dx.doi.org/10.1007/s00381-020-04780-7DOI Listing

Outcome in 32 cases of tethered cord in adults-is intervention justified?

Childs Nerv Syst 2020 Jul 8. Epub 2020 Jul 8.

DNBNeurosurgery, MNAMS(Neurosurgery),FRCS(SN), VIMS and Park Clinic, Kolkata, India.

Introduction: Adults rarely present with tethered cord syndrome, and this review examines whether it is justifiable to perform surgical intervention in this group.

Methods: Between 2003 and 2017, we performed surgical intervention in 32 adults with tethered cord syndrome. The age range varied from 22 to 65 years. Read More

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http://dx.doi.org/10.1007/s00381-020-04774-5DOI Listing

Microvascular injury and hypoxic damage: emerging neuropathological signatures in COVID-19.

Acta Neuropathol 2020 Jul 8. Epub 2020 Jul 8.

Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1007/s00401-020-02190-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340758PMC

Selective dorsal rhizotomy: functional anatomy of the conus-cauda and essentials of intraoperative neurophysiology.

Childs Nerv Syst 2020 Jul 7. Epub 2020 Jul 7.

Section of Neurosurgery, Department of Neurosciences, Biomedicine and Movement Sciences, University Hospital, Verona, Italy.

Introduction: Spasticity is the result of an exaggeration of the monosynaptic muscle stretch reflex due to lesions affecting the central nervous system, in particular an upper motor neuron lesion. Selective dorsal rhizotomy (SDR) is a surgical technique developed to treat spastic diplegia, one of the common forms of cerebral palsy, resulting from the lack of supraspinal inhibitory controls. The aim of SDR is to identify and cut a critical amount of the sensory rootlets, in particular those contributing the most to spasticity, in order to relieve the patient from lower limb spasticity while preserving motor strength and sphincter control. Read More

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http://dx.doi.org/10.1007/s00381-020-04746-9DOI Listing

Chopping the tail: how preventing superspreading can help to maintain COVID-19 control.

medRxiv 2020 Jul 3. Epub 2020 Jul 3.

Disease transmission is notoriously heterogeneous, and SARS-CoV-2 is no exception. A skewed distribution where few individuals or events are responsible for the majority of transmission can result in explosive, superspreading events, which produce rapid and volatile epidemic dynamics, especially early or late in epidemics. Anticipating and preventing superspreading events can produce large reductions in overall transmission rates. Read More

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http://dx.doi.org/10.1101/2020.06.30.20143115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340192PMC

Shunt timing in meningomyelocele and clinical results: analysis of 80 cases.

Childs Nerv Syst 2020 Jul 6. Epub 2020 Jul 6.

Neurosurgery Department, Adana City Training and Research Hospital, Adana, Turkey.

Purpose: Meningomyelocele is a serious pathology that requires immediate surgical treatment. Its management is difficult due to accompanying other pathologies and hydrocephalus. Shunt timing is still controversial. Read More

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http://dx.doi.org/10.1007/s00381-020-04786-1DOI Listing

Infected congenital cervical dermal sinuses leading to spinal cord abscess: two case reports and a review of the literature.

Childs Nerv Syst 2020 Jul 6. Epub 2020 Jul 6.

Department of Paediatric Neurosurgery, University Hospital of Wales, Cardiff, UK.

Purpose: Congenital dermal sinuses are a rare form of spinal dysraphism. The developmental defects are located along the midline neuroaxis, with sinuses in the cervical region being the least common. Congenital dermal sinuses can be associated with intraspinal infection as they act as a direct route from the skin and subcutaneous tissues into the spinal cord. Read More

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http://dx.doi.org/10.1007/s00381-020-04778-1DOI Listing

Professor Wolfgang Wagner, the President of ISPN (2018-2019).

Authors:
Kyu-Chang Wang

Childs Nerv Syst 2020 Jul 6. Epub 2020 Jul 6.

National Cancer Center, Goyang, Republic of Korea.

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http://dx.doi.org/10.1007/s00381-020-04782-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338140PMC

Individual differences determine the strength of ecological interactions.

Proc Natl Acad Sci U S A 2020 Jul 6. Epub 2020 Jul 6.

Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, United Kingdom.

Biotic interactions are central to both ecological and evolutionary dynamics. In the vast majority of empirical studies, the strength of intraspecific interactions is estimated by using simple measures of population size. Biologists have long known that these are crude metrics, with experiments and theory suggesting that interactions between individuals should depend on traits, such as body size. Read More

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http://dx.doi.org/10.1073/pnas.2000635117DOI Listing

Contrasting effects of climate change on seasonal survival of a hibernating mammal.

Proc Natl Acad Sci U S A 2020 Jul 6. Epub 2020 Jul 6.

Department of Evolutionary Biology and Environmental Studies, University of Zurich, CH-8057 Zurich, Switzerland.

Seasonal environmental conditions shape the behavior and life history of virtually all organisms. Climate change is modifying these seasonal environmental conditions, which threatens to disrupt population dynamics. It is conceivable that climatic changes may be beneficial in one season but result in detrimental conditions in another because life-history strategies vary between these time periods. Read More

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http://dx.doi.org/10.1073/pnas.1918584117DOI Listing

Ante-natal counseling in phacomatoses.

Childs Nerv Syst 2020 Jul 5. Epub 2020 Jul 5.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objectives: Phacomatoses are a group of neuro-oculo-cutaneous syndromes/ neurocutaneous disorders, involving structures arising from the embryonic ectoderm. Most of phacomatoses including the most common ones:, neurofibromatosis type I and type II (NF1, NF2) and tuberosclerosis complex (TSC), are autosomal dominant genetic disorders with full penetrance and variable expression. As no effective treatment exists, the only way to prevent the disease, is by prenatal genetic diagnosis (either chorionic villus sampling-CVS or amniocentesis-AC) and termination of pregnancy or performing preimplantation genetic testing (PGT). Read More

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http://dx.doi.org/10.1007/s00381-020-04776-3DOI Listing

Supplemental income program design: A cluster-randomized controlled trial to examine the health and wellbeing effects on older adults by gender, duration, and payment frequency.

Soc Sci Med 2020 Jun 26;259:113139. Epub 2020 Jun 26.

RAND Corporation, 1776 Main Street, Santa Monica, CA, 90401, USA.

Background: We documented results from a cluster-randomized controlled trial we designed to supplement incomes in poor towns among adults 70 or older. We analyzed effects on health by gender, persistence over time, and variation by payment frequency.

Methods: We compared supplemental income effects over an 18-month period for two towns in Yucatan, Mexico: Valladolid, where eligible individuals received a monthly income supplement over the entire analysis period, and Motul, a demographically matched control town, where eligible individuals received a bimonthly income supplement over the last 12 months of the analysis period. Read More

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http://dx.doi.org/10.1016/j.socscimed.2020.113139DOI Listing

Cervical myelomeningocele with CSF leakage: a case-based review.

Childs Nerv Syst 2020 Jul 4. Epub 2020 Jul 4.

Neurosurgery Department, Hospital Regional Universitario de Málaga, Málaga, Spain.

Background: The cystic spinal dysraphism of the cervical and upper thoracic region (CDCT) accounts for only 3.9 to 8% of spina bifida cystica lesions. The presence of external cerebrospinal fluid (CSF) leakage is infrequent and very few authors have reported about surgical complications. Read More

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http://dx.doi.org/10.1007/s00381-020-04743-yDOI Listing

Dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease) presenting as a prenatally heterotopic hamartoma.

Childs Nerv Syst 2020 Jul 3. Epub 2020 Jul 3.

Department of Pediatric Neurosurgery, Rennes University Hospital, Rennes, France.

Dysplastic gangliocytoma of the cerebellum (DGC), also called Lhermitte-Duclos disease, is a rare lesion of the posterior fossa consisting of a diffuse hypertrophy of the cerebellar cortex. DGC frequently presents in young adults and rarely in childhood. Only 3 cases have been previously described in newborns. Read More

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http://dx.doi.org/10.1007/s00381-020-04785-2DOI Listing

Seroprevalence of Measles, Rubella, Tetanus, and Diphtheria Antibodies among Children in Haiti, 2017.

Am J Trop Med Hyg 2020 Jul 6. Epub 2020 Jul 6.

Global Immunization Division, Centers for Disease Control and Prevention, Atlanta, Georgia.

In Haiti, measles, rubella, and maternal and neonatal tetanus have been eliminated, but a diphtheria outbreak is ongoing as of 2019. We conducted a national representative, household-based, two-stage cluster survey among children aged 5-7 years in 2017 to assess progress toward maintenance of control and elimination of selected vaccine-preventable diseases (VPDs). We stratified Haiti into west region (west department, including the capital city) and non-west region (all other departments). Read More

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http://dx.doi.org/10.4269/ajtmh.20-0112DOI Listing

An executive functioning perspective in neurofibromatosis type 1: from ADHD and autism spectrum disorder to research domains.

Childs Nerv Syst 2020 Jul 3. Epub 2020 Jul 3.

Office of the Clinical Director and Medical Genetic Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

Purpose: Neurofibromatosis type 1 (NF1) is a rare monogenic disorder associated with executive function (EF) deficits and heightened risk for attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). The goal of this paper is to understand how EFs provide a common foundation to understand vulnerabilities for ADHD and ASD within NF1.

Methods: A literature review and synthesis was conducted. Read More

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http://dx.doi.org/10.1007/s00381-020-04745-wDOI Listing

Fronto-orbital advancement in a patient with Marshall-Smith syndrome: a case report and review of the literature.

Childs Nerv Syst 2020 Jul 2. Epub 2020 Jul 2.

Department of Plastic and Reconstructive Surgery, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.

Objective: The present report aimed to document the clinical features of a case of Marshall-Smith syndrome (MSS), an extremely rare embryonic developmental disorder with associated craniosynostosis.

Patient And Method: We presented herein a case of a 2-year-old female patient with MSS who underwent fronto-orbital advancement for multisuture craniosynostosis.

Results: The patient's proptosis improved after surgery, and no further surgical intervention was required for corneal exposure. Read More

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http://dx.doi.org/10.1007/s00381-020-04741-0DOI Listing

Adamantinomatous craniopharyngioma: advances in proteomic research.

Childs Nerv Syst 2020 Jul 2. Epub 2020 Jul 2.

UOC Neurochirurgia Infantile, Dipartimento di Scienze dell'Invecchiamento, Neurologiche, Ortopediche e della Testa-Collo; Fondazione Policlinico Universitario A. Gemelli - IRCCS, Università Cattolica del Sacro Cuore, Largo Gemelli 1, 00168, Rome, Italy.

Background: Many efforts have been performed in the last decade to accomplish the genomic and proteomic characterization of pediatric adamantinomatous craniopharyngioma with the purpose to elucidate the molecular mechanisms underlying the onset and development of this pediatric brain tumor, its high recurrence rate, and, although classified as a histologically benign neoplasm, its aggressive behavior.

Methods: The focus of this review is to perform the new comparison of the proteomic profiles of the solid component and the intracystic fluid of adamantinomatous craniopharyngioma based on our previous results, obtained by both the top-down and the bottom-up proteomic approaches, to disclose differences and similarities, and to discuss the results in the context of the most recent literature.

Results And Conclusions: Proteins and peptides identified in the cyst fluid and in the solid component of adamantinomatous craniopharyngioma (AC) include beyond markers of inflammation (i. Read More

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http://dx.doi.org/10.1007/s00381-020-04750-zDOI Listing

Letter to the editor regarding "Selective dorsal rhizotomy for spasticity of genetic etiology".

Childs Nerv Syst 2020 Jul 2. Epub 2020 Jul 2.

Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, 110029, India.

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http://dx.doi.org/10.1007/s00381-020-04787-0DOI Listing

The first 2 months of COVID-19 contact tracing in the Northern Territory of Australia, March-April 2020.

Commun Dis Intell (2018) 2020 Jul 2;44. Epub 2020 Jul 2.

Centre for Disease Control, Public Health Unit, Top End Health Service, Northern Territory Government Department of Health, Darwin, Northern Territory, Australia.

The Northern Territory (NT) Centre for Disease Control (CDC) undertook contact tracing of all notified cases of coronavirus disease 2019 (COVID-19) within the Territory. There were 28 cases of COVID-19 notified in the NT between 1 March and 30 April 2020. In total 527 people were identified as close contacts over the same period; 493 were successfully contacted; 445 were located in the NT and were subsequently quarantined and monitored for disease symptoms daily for 14 days after contact with a confirmed COVID-19 case. Read More

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http://dx.doi.org/10.33321/cdi.2020.44.53DOI Listing

Post-mortem histopathology of a pediatric brain after bilateral DBS of GPI for status dystonicus: case report and review of the literature.

Childs Nerv Syst 2020 Jul 2. Epub 2020 Jul 2.

Pediatric Anesthesiology and Intensive Care Unit, Children's Hospital A. Meyer-University of Florence, Florence, Italy.

Purpose: To investigate the effects of deep brain stimulation (DBS) electrodes on the brain of a dystonic pediatric patient submitted to bilateral DBS of the globus pallidus internus (GPI).

Methods: An 8-year-old male patient underwent bilateral DBS of GPI for status dystonicus. He died 2 months later due to multiorgan failure triggered by bacterial pneumonia. Read More

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http://dx.doi.org/10.1007/s00381-020-04761-wDOI Listing

A boy with a congenital cerebellar mass.

Childs Nerv Syst 2020 Jul 1. Epub 2020 Jul 1.

Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Purpose: Tumorigenesis of medulloblastoma is believed to be associated with granule cell progenitor neurogenesis of the cerebellum. Nevertheless, congenital medulloblastomas are rarely found. Here, we report a case of congenital medulloblastoma that showed spontaneous albeit transient regression. Read More

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http://dx.doi.org/10.1007/s00381-020-04767-4DOI Listing

Epilepsy in NF1: a systematic review of the literature.

Childs Nerv Syst 2020 Jul 1. Epub 2020 Jul 1.

Pediatric Psychiatry and Neurology, Department of Neuroscience, Santobono-Pausilipon Children's Hospital, Naples, Italy.

Epilepsy is one of the possible neurological manifestations of the neurofibromatosis type 1 (NF1) that represents the most common neurocutaneous disorder. We performed a systematic review of the literature on epilepsy associated with NF1 since 1995 in order to better define prevalence and describe type and causes of seizures. Data on type, nature of studies, number of patients, gender, and inheritance of NF1 were recorded as well as data on causes, type, EEGs, brain imaging, intellectual disability (ID), surgical treatment, and outcome of epilepsy. Read More

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http://dx.doi.org/10.1007/s00381-020-04710-7DOI Listing

Management of spinal deformities and tibial pseudarthrosis in children with neurofibromatosis type 1 (NF-1).

Childs Nerv Syst 2020 Jul 1. Epub 2020 Jul 1.

Altona Children's Hospital - AKK/UKE, Bleickenallee 38, 22763, Hamburg, Germany.

The skeletal system is affected in up to 60% of patients with neurofibromatosis type 1. The most commonly observed entities are spinal deformities and tibial dysplasia. Early recognition of radiologic osseous dystrophy signs is of utmost importance because worsening of the deformities without treatment is commonly observed and surgical intervention is often necessary. Read More

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http://dx.doi.org/10.1007/s00381-020-04775-4DOI Listing

Multisystem disease including stroke, epilepsy, dystonia, noncompaction, and kidney agenesis requires genetic work-up.

Authors:
Josef Finsterer

Childs Nerv Syst 2020 Jul 1. Epub 2020 Jul 1.

Krankenanstalt Rudolfstiftung, Messerli Institute, Postfach 20, 1180, Vienna, Austria.

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http://dx.doi.org/10.1007/s00381-020-04781-6DOI Listing

C2 spinal nerve tumors in young adults: report of two cases and review of the literature.

Childs Nerv Syst 2020 Jul 1. Epub 2020 Jul 1.

Almazov National Medical Research Centre, Akkuratova str. 2, St. Petersburg, Russian Federation.

C2 spinal nerve schwannomas are rarely encountered, especially in children and young adults. Due to their localization surgical management encompasses a number of distinctive features. We describe two cases of C2 spinal nerve tumors, schwannoma and neurofibroma, in patients aged 13 and 17, respectively. Read More

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http://dx.doi.org/10.1007/s00381-020-04777-2DOI Listing

Current status of MEK inhibitors in the treatment of plexiform neurofibromas.

Childs Nerv Syst 2020 Jun 30. Epub 2020 Jun 30.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, 10 Center Drive, Building 10, Room 1-3752, Bethesda, MD, 20892, USA.

Background: Neurofibromatosis type 1 (NF1)-related plexiform neurofibromas (pNF) can be debilitating and until recently, surgery was the only potentially effective therapy for these tumors.

Methods: We review critical steps in the path towards the FDA approval of the first medical therapy for NF1 pNF and the current status of MEK inhbitor therapy.

Results: Sustained efforts by the NF community have resulted in a detailed understanding of the natural history and biology of NF1-related peripheral nerve sheath tumors. Read More

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http://dx.doi.org/10.1007/s00381-020-04731-2DOI Listing

Genetic basis of neurofibromatosis type 1 and related conditions, including mosaicism.

Childs Nerv Syst 2020 Jun 29. Epub 2020 Jun 29.

Department of Human Genetics, University of Leuven, Herestraat 49, 3000, Leuven, Belgium.

Introduction: Neurofibromatosis type 1 (NF1) is a frequent autosomal dominant disorder characterised by café-au-lait maculae (CALM), skinfold freckling, iris Lisch nodules and benign peripheral nerve sheath tumours (neurofibromas).

Mechanism: The NF1 gene is a tumour suppressor gene and NF1 individuals have an increased risk for a long list of tumours, all resulting from a second hit in the normal copy of the NF1 gene. Remarkably, some non-tumour phenotypes such as CALM and pseudarthrosis are also caused by a "second hit". Read More

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http://dx.doi.org/10.1007/s00381-020-04771-8DOI Listing

New treatment modalities in NF-related neuroglial tumors.

Childs Nerv Syst 2020 Jun 29. Epub 2020 Jun 29.

Division of Radiology, Children's National Hospital, 111 Michigan Ave, NW, Washington, DC, 20010, USA.

The management of low-grade gliomas (LGGs) and other neuroglial tumors in children with neurofibromatosis type 1 (NF1) has not changed over the past 2-3 decades. With the widespread utilization of chemotherapy for younger children with progressive LGGs, outcomes have been good for most patients who have required treatment. However, some may progress after the initiation of chemotherapy and others, although radiographically responding or with stable disease, may develop progressive neurologic and visual deterioration. Read More

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http://dx.doi.org/10.1007/s00381-020-04704-5DOI Listing

Fetal therapy for congenital hydrocephalus-where we came from and where we are going.

Childs Nerv Syst 2020 Jun 29. Epub 2020 Jun 29.

Neurosurgery Division, Department of Neurology, State University of Campinas (UNICAMP), Campinas, SP, Brazil.

Despite unfavorable outcomes during the early experience with in utero intervention for congenital hydrocephalus, improvements in prenatal diagnosis, patient selection, and fetal surgery techniques have led to a renewed interest in fetal intervention for congenital hydrocephalus. Research studies and clinical evidence shows that postnatal cerebrospinal fluid diversion to release intraventricular pressure and cerebral mantle compression usually arrives late to avoid irreversible brain damage. Make sense to decompress those lateral ventricles as soon as possible during the intrauterine life when hydrocephalus is antenatally detected. Read More

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http://dx.doi.org/10.1007/s00381-020-04738-9DOI Listing

Combined microsurgical fluorescence for optimizing resection in refractory empyema and cerebritis.

Childs Nerv Syst 2020 Jun 29. Epub 2020 Jun 29.

Department of Neurosurgery, University Hospital Vírgen del Rocío, Sevilla, Sevilla, Spain.

Purpose: Due to the generalization of new microsurgical equipment, intraoperative fluorescence techniques have extended in neurosurgical practice, mainly in neurovascular and neuro-oncology patients. The aim of identifying pathological tissue and also differentiating from the normal brain helps neurosurgeons to approach other kinds of intracranial entities such as infections.

Methods: It is described in the case of an 11-year-old patient who underwent a subdural empyema by performing a craniotomy and evacuation of the purulent collection. Read More

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http://dx.doi.org/10.1007/s00381-020-04762-9DOI Listing

Clinical features associated with the development of hydrocephalus following TBI in the paediatric age group.

Childs Nerv Syst 2020 Jun 29. Epub 2020 Jun 29.

Department of Neurosurgery, University Hospital Wales, 4th Floor, Heath Park Way, Cardiff, CF14 4XW, UK.

Introduction: Predictive factors for post-traumatic hydrocephalus (PTH) in adults have been elucidated but remain uncertain for children. We aimed to identify the prevalence of PTH in paediatric patients and identify clinical/radiological factors which may increase the probability of children developing PTH.

Methods: This was a retrospective study of all patients < 16 years old admitted to our unit with traumatic brain injury (TBI) between March 2013 and June 2018, 108 patients in total. Read More

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http://dx.doi.org/10.1007/s00381-020-04764-7DOI Listing

Occult tethered cord syndrome: a reversible cause of paraparesis not to be missed.

Childs Nerv Syst 2020 Jun 28. Epub 2020 Jun 28.

Second Department of Psychiatry, School of Medicine, University General Hospital "Attikon", Athens, Greece.

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http://dx.doi.org/10.1007/s00381-020-04768-3DOI Listing

Preoperative planning with a 3D model and repair of sphenoid dysplasia: a technical note.

Childs Nerv Syst 2020 Jun 27. Epub 2020 Jun 27.

Department of Maxillofacial and Oral Surgery, University Medical Centre Ljubljana, Ljubljana, Slovenia.

Introduction: Sphenoid dysplasia is a distinctive marker of neurofibromatosis 1. It is a malformation of the sphenoid bone characterized by an enlargement of the superior orbital fissure, through which the intracranial content herniates, leading to a facial disfigurement and exophthalmos and to a potential visual deterioration. Surgical treatment has the aim of separating the intracranial from the intraorbital space. Read More

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http://dx.doi.org/10.1007/s00381-020-04759-4DOI Listing

Changes in age-structure over four decades were a key determinant of population growth rate in a long-lived mammal.

J Anim Ecol 2020 Jun 27. Epub 2020 Jun 27.

Department of Biology, University of Turku, 20500, Turku, Finland.

1. A changing environment directly influences birth and mortality rates, and thus population growth rates. However, population growth rates in the short-term are also influenced by population age-structure. Read More

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http://dx.doi.org/10.1111/1365-2656.13290DOI Listing

Pudendal mapping of S1 rootlets in a functional posterior rhizotomy: when an S1 posterior root shows a high pudendal dorsal action potential-a technical note.

Authors:
Nobuhito Morota

Childs Nerv Syst 2020 Jun 27. Epub 2020 Jun 27.

Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-Ku, Sagamihara, Kanagawa, 252-0375, Japan.

Background: The standard level for lesioning in a functional posterior rhizotomy (FPR) ranges from L2 to S1/S2. Lesioning of the S1 and S2 rootlets strongly correlates with a reduction in ankle spasticity. In the Japanese population, the S2 root often shows the highest dorsal root action potentials (DAPs) in the afferent fibers of the pudendal nerve and is not lesioned to preserve postoperative urinary function. Read More

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http://dx.doi.org/10.1007/s00381-020-04751-yDOI Listing

Clinical features and long-term outcomes of pediatric spinal cord cavernous malformation-a report of 18 cases and literature review.

Childs Nerv Syst 2020 Jun 26. Epub 2020 Jun 26.

Medical School of Nankai University, No. 94, Weijin Road, Naikai District, Tianjin, 300071, People's Republic of China.

Purpose: Pediatric intramedullary spinal cord cavernous malformation (ISCM) is a rare vascular disease with unclear natural history and long-term outcomes. We aim to determine the demographics, hemorrhagic risk, and long-term outcomes of this rare entity.

Methods: A retrospective review of clinical data and treatment outcomes of pediatric patients treated with ISCM in our institution from 3/2000 to 3/2017 was conducted. Read More

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http://dx.doi.org/10.1007/s00381-020-04700-9DOI Listing

Peritoneal insertion of shunts in children: comparison between trocar and laparoscopically guided insertion.

Childs Nerv Syst 2020 Jun 26. Epub 2020 Jun 26.

Department of Pediatric Neurosurgery, Dana Children's Hospital, Tel-Aviv Medical Center, 6 Weizman Street, 64239, Tel Aviv, Israel.

Purpose: Ventriculo-peritoneal shunts are commonly used for treating hydrocephalus for all age groups. There are 3 main methods for shunt placement into the peritoneum: mini laparotomy, laparoscopically guided, or percutaneously with a trocar. There is limited literature comparing between these techniques in the pediatric population, and specifically-the trocar has not been compared with laparoscopy. Read More

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http://dx.doi.org/10.1007/s00381-020-04760-xDOI Listing

Abnormal spindle-like microcephaly-associated (ASPM) gene expression in posterior fossa brain tumors of childhood and adolescence.

Childs Nerv Syst 2020 Jun 26. Epub 2020 Jun 26.

Department of Pediatrics, Pediatric Oncology Institute-GRAACC, Federal University of São Paulo, São Paulo, SP, Brazil.

Purpose: In neurogenesis, ASPM (abnormal spindle-like microcephaly-associated) gene is expressed mainly in the ventricular zone of posterior fossa and is the major determinant in the cerebral cortex. Besides its role in embryonic development, ASPM overexpression promotes tumor growth, including central nervous system (CNS) tumors. This study aims to investigate ASPM expression levels in most frequent posterior fossa brain tumors of childhood and adolescence: medulloblastoma (MB), ependymoma (EPN), and astrocytoma (AS), correlating them with clinicopathological characteristics and tumor solid portion size. Read More

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http://dx.doi.org/10.1007/s00381-020-04740-1DOI Listing

Transcallosal-lateral ventricle-choroid fissure approach for excising large pineal region tumors extending into the third ventricle: experience in 15 pediatric cases.

Childs Nerv Syst 2020 Jun 25. Epub 2020 Jun 25.

Department of Neurosurgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530007, Guangxi, People's Republic of China.

Pineal region is deep located and tightly connected with surrounding important nerves, blood vessels, and other critical structure. Tumors in the regions are more commonly observed in children with complex pathology, difficult surgery, and poor prognosis. However, excision surgery on large tumor in the pineal region and extending into the third ventricle is characterized by high difficulty and uneasy treatment. Read More

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http://dx.doi.org/10.1007/s00381-020-04742-zDOI Listing

Frequency distribution in intraoperative stimulation-evoked EMG responses during selective dorsal rhizotomy in children with cerebral palsy-part 2: gender differences and left-biased asymmetry.

Childs Nerv Syst 2020 Jun 25. Epub 2020 Jun 25.

Division of Pediatric Neurosurgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 13353, Berlin, Germany.

Introduction: Spinal reflexes reorganize in cerebral palsy (CP), producing hyperreflexia and spasticity. CP is more common among male infants, and gender might also influence brain and spinal-cord reorganization. This retrospective study investigated the frequency of higher-graded EMG responses elicited by electrical nerve-root stimulation during selective dorsal rhizotomy (SDR), prior to partial nerve- root deafferentation, considering not only segmental level and body side, but also gender. Read More

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http://dx.doi.org/10.1007/s00381-020-04735-yDOI Listing

Midface distraction osteogenesis using a modified external device and 3D virtual simulation: technical note.

Childs Nerv Syst 2020 Jun 25. Epub 2020 Jun 25.

Department of Oral and Maxillofacial Surgery, School of Dentistry, University of São Paulo, São Paulo, Brazil.

Introduction/background: Distraction osteogenesis (DO) with an external distraction device such as the rigid external distraction frame has become an established method for treating midface hypoplasia in faciocraniosynostosis. It allows for greater advancement of the midface in comparison with traditional Le Fort III osteotomies, associated or not with fronto-orbital osteotomies (Le Fort IV). However, the forward movement of the bone segments may not always be performed obeying an ideal distraction vector, resulting in asymmetries, anterior open bite, and loosening of screws. Read More

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http://dx.doi.org/10.1007/s00381-020-04730-3DOI Listing

Craniofacial bone alterations in patients with neurofibromatosis type 1.

Childs Nerv Syst 2020 Jun 25. Epub 2020 Jun 25.

Université Claude Bernard Lyon 1, 43 Boulevard du 11 Novembre 1918, 69100, Villeurbanne, France.

Osseous manifestations of neurofibromatosis 1 (NF-1) occur in a minority of the affected subjects but may be because of significant clinical impairment. Typically, they involve the long bones, commonly the tibia and the fibula, the vertebrae, and the sphenoid wing. The pathogenesis of NF-1 focal osseous lesions and its possible relationships with other osseous NF-1 anomalies leading to short stature are still unknown, though it is likely that they depend on a common mechanism acting in a specific subgroup of NF-1 patients. Read More

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http://dx.doi.org/10.1007/s00381-020-04749-6DOI Listing

Neurological manifestations of pediatric multi-system inflammatory syndrome potentially associated with COVID-19.

Childs Nerv Syst 2020 Jun 25. Epub 2020 Jun 25.

Department of Neurosurgery, Mount Sinai Health System, 1468 Madison Avenue, Annenberg 8th Floor, New York, NY, 10029, USA.

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http://dx.doi.org/10.1007/s00381-020-04755-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314616PMC

Correction to: Stingray spear injury to the pediatric spinal cord: case report and review of the literature.

Childs Nerv Syst 2020 Jun 25. Epub 2020 Jun 25.

Servicio de Neurocirugía, Hospital Nacional de Niños, "Dr. Carlos Sáenz Herrera", San José, Costa Rica.

The original version of this article unfortunately contained an error in the spelling of the last name of one of the co-authors. The corresponding author did not notice that the last name of one of the co-authors, Nathan Shlobin, was misspelled as "Schlobin". The correct spelling of his last name is "Shlobin". Read More

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http://dx.doi.org/10.1007/s00381-020-04739-8DOI Listing

Henry Gray (1827-1861): the great author of the most widely used resource in medical education.

Childs Nerv Syst 2020 Jun 24. Epub 2020 Jun 24.

Faculty of Medicine, Department of Anatomy, Istanbul University, Istanbul, Turkey.

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http://dx.doi.org/10.1007/s00381-020-04748-7DOI Listing

Long term outcome of Selective Dorsal Rhizotomy for the management of childhood spasticity-functional improvement and complications.

Childs Nerv Syst 2020 Jun 23. Epub 2020 Jun 23.

Division of Pediatric Neurosurgery, Children's Hospital of British Columbia, Vancouver, Canada.

Background: Selective dorsal rhizotomy (SDR) for the management of lower extremity spasticity is a surgical technique that has existed since the 1900s. While much evidence supports its efficaciousness in reducing tone in the short term, limited information exists detailing the long-term outcome and evolution over time of patients undergoing SDR.

Methods: All publications with 10 years or more of outcome data on patients undergoing SDR were identified from Medline and Embase databases using the search term "Rhizotmy. Read More

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http://dx.doi.org/10.1007/s00381-020-04747-8DOI Listing