2,493,648 results match your criteria Children & Society[Journal]


Outcomes and factors associated with early mortality in pediatric post-cardiotomy veno-arterial extracorporeal membrane oxygenation.

Artif Organs 2020 Jul 9. Epub 2020 Jul 9.

Department of Cardiopulmonary Bypass, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Mortality and morbidity of children received veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support after cardiac surgery remain high despite remarkable advances in medical management and devices. The purpose of this study was to describe outcomes and risk factors of applying VA-ECMO in the surgical pediatric population. We retrospectively analyzed 85 consecutive pediatric patients (aged <18 years) who received post-cardiotomy VA-ECMO from January 2010 to December 2018. Read More

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http://dx.doi.org/10.1111/aor.13773DOI Listing

Healthcare interventions improving and reducing quality of life in children at the end of life: a systematic review.

Pediatr Res 2020 Jul 9. Epub 2020 Jul 9.

End-of-Life Care Research Group, Vrije Universiteit Brussel and Ghent University, Brussels Health Campus-Building K Laarbeeklaan 103, 1090, Brussels, Belgium.

Background: Children with serious illness suffer from symptoms at the end of life that often fail to be relieved. An overview is required of healthcare interventions improving and decreasing quality of life (QOL) for children with serious illness at the end of life.

Methods: A systematic review was performed in five databases, January 2000 to July 2018 without language limit. Read More

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http://dx.doi.org/10.1038/s41390-020-1036-xDOI Listing

An Exploration into Mothers' Experiences of Feeding Children with Autism Spectrum Disorder in South Africa.

Folia Phoniatr Logop 2020 Jul 9:1-10. Epub 2020 Jul 9.

Department of Speech Pathology and Audiology, School of Human and Community Development, University of the Witwatersrand, Johannesburg, South Africa.

Objectives: To explore the experiences of mothers feeding their children with autism spectrum disorder (ASD) in South Africa as well as to better understand the impact of context and culture on feeding disorders.

Participants And Methods: A qualitative research design was employed. Seven mothers of 8 children (1 mother had twins), aged 4-9 years, who were diagnosed with ASD and who had associated feeding difficulties participated in the study. Read More

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http://dx.doi.org/10.1159/000507928DOI Listing

Is macrophages heterogeneity important in determining COVID-19 lethality?

Med Hypotheses 2020 Jul 3;143:110073. Epub 2020 Jul 3.

Dpt Clinical and Biological Sciences, University of Torino, Italy. Electronic address:

COVID-19 (coronavirus disease 2019) pandemic due to infection with SARS-CoV-2 has led to the death of thousands of adults worldwide. It is now clear that the hyper-inflammatory response triggered by SARS-CoV-2 plays a major role in disease severity and lethality of the infection. Macrophages are innate immune cells that sense and respond to infections by producing a plethora of inflammatory molecules and by interacting with other inflammatory cells. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.110073DOI Listing

Baricitinib, a drug with potential effect to prevent SARS-COV-2 from entering target cells and control cytokine storm induced by COVID-19.

Int Immunopharmacol 2020 Jul 1;86:106749. Epub 2020 Jul 1.

Department of Pharmacy, Wuxi People's Hospital Attached to Nanjing Medical University, Wuxi 214023, Jiangsu, China. Electronic address:

In December 2019, a novel coronavirus pneumonia (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suddenly broke out in China and rapidly spread all over the world. Recently, a cell surface protein, known as angiotensin-converting enzyme II (ACE2), has been identified to be involved in receptor-mediated endocytosis for SARS-CoV-2 entry to the cells. Many studies have reported the clinical characteristics of COVID-19: sudden deterioration of disease around 1-2 weeks after onset; much lower level of lymphocytes, especially natural killer (NK) cells in peripheral blood; extremely high pro-inflammatory cytokines and C reactive protein (CRP). Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106749DOI Listing

Evaluation of safety, efficacy, tolerability, and treatment-related outcomes of type I interferons for human coronaviruses (HCoVs) infection in clinical practice: An updated critical systematic review and meta-analysis.

Int Immunopharmacol 2020 Jun 25;86:106740. Epub 2020 Jun 25.

Children's Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing, China; National Clinical Research Center for Child Health and Disorders, Chongqing, China; Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China; Chongqing Key Laboratory of Pediatrics Chongqing, Chongqing, China; Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Background: There is no vaccine or specific antiviral treatment for HCoVs infection. The use of type I interferons for coronavirus is still under great debate in clinical practice.

Materials And Methods: A literature search of all relevant studies published on PubMed, Cochrane library, Web of Science database, Science Direct, Wanfang Data, and China National Knowledge Infrastructure (CNKI) until February 2020 was performed. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106740DOI Listing
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