2,584 results match your criteria Childhood-a Global Journal Of Child Research[Journal]


Risk of Mercury exposure during childhood: a review of Sri Lankan situation.

Rev Environ Health 2020 Jul 3. Epub 2020 Jul 3.

Environmental and Occupational Health Directorate, Ministry of Healthcare & Indigenous Medical Services, Colombo, Sri Lanka.

Sri Lanka had ratified the Minamata convention in the year 2017 and is planning to phase out Mercury by 2020. Mercury thermometers and compact fluorescent light bulbs are abundant at hospitals, households and schools. Limitations in safe disposal and containment mechanisms have enhanced the unregulated e-waste collection and extraction. Read More

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http://dx.doi.org/10.1515/reveh-2020-0024DOI Listing

Hurthle cell carcinoma in childhood: A retrospective analysis of five cases and review of pediatric literature.

Pediatr Blood Cancer 2020 Jul 2:e28300. Epub 2020 Jul 2.

Division of Pediatrics, Department of Human Pathology in Adulthood and Childhood, University of Messina, Messina, Italy.

Background: the available studies on Hurthle cell carcinoma (HCC) in pediatric age are scarce and based on isolated case reports. Aims of the present study were to review the available pediatric literature on HCC (2000-2019), to describe the cohort of children with this cancer histotype, and to estimate its relative prevalence in pediatric age.

Procedure: We retrospectively reconstructed an HCC course in five patients < 19 years who were identified in our departments during the period 2000-2019, and we reviewed the available pediatric studies on this differentiated thyroid cancer (DTC) variant. Read More

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http://dx.doi.org/10.1002/pbc.28300DOI Listing

The temperament features associated with autism spectrum disorder in childhood: A systematic review.

Res Dev Disabil 2020 Jun 26;104:103711. Epub 2020 Jun 26.

School of Psychology, University of Newcastle, Callaghan, Australia; Priority Research Centre GrowUpWell®, University of Newcastle, Australia. Electronic address:

Background: Temperament is an important construct that shapes child development. Temperament is suggested to present differently in different groups, such as children with neurodevelopmental disorders. However, it is not known whether there are specific temperament features associated with Autism Spectrum Disorder (ASD). Read More

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http://dx.doi.org/10.1016/j.ridd.2020.103711DOI Listing

Prenatal and postnatal exposures to ambient air pollutants associated with allergies and airway diseases in childhood: A retrospective observational study.

Environ Int 2020 Jun 22;142:105853. Epub 2020 Jun 22.

Department of Building Environment and Energy Engineering, School of Environment and Architecture, University of Shanghai for Science and Technology, Shanghai, China.

It's inconsistent about associations of early exposures to outdoor air pollutants with allergies and airway diseases in childhood. Here, we investigated associations of prenatal and postnatal exposures to outdoor nitrogen dioxide (NO), sulphur dioxide (SO), and PM (particulate matter with an aerodynamic diameter ≤ 10 μm) with asthma, wheeze, hay fever, rhinitis, pneumonia, and eczema in childhood. We surveyed 3,177 preschoolers who never change residences since birth in Shanghai, China. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105853DOI Listing

Psychotic experiences and future school performance in childhood: a population-based cohort study.

J Child Psychol Psychiatry 2020 Jun 19. Epub 2020 Jun 19.

Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Centre-Sophia Children's Hospital, Rotterdam, The Netherlands.

Background: Psychotic experiences are common in childhood and an important risk indicator of adverse mental health outcomes. However, little is known about the association of psychotic experiences with functional outcomes in childhood, particularly regarding school performance. The aim of the present study was to examine whether psychotic experiences were prospectively related to school performance in childhood. Read More

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http://dx.doi.org/10.1111/jcpp.13281DOI Listing

Dietary factors during pregnancy and atopic outcomes in childhood: a systematic review from the European Academy of Allergy and Clinical Immunology.

Pediatr Allergy Immunol 2020 Jun 10. Epub 2020 Jun 10.

Depts of Medicine and Microbiology, APC Microbiome Ireland, National University of Ireland, Cork, Ireland.

Rationale: Allergic diseases are an increasing public health concern and early life environment is critical to immune development. Maternal diet during pregnancy has been linked to offspring allergy risk. In turn, maternal diet is a potentially modifiable factor, which could be targeted as an allergy prevention strategy. Read More

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http://dx.doi.org/10.1111/pai.13303DOI Listing

Maturation of nasal microbiota and antibiotic exposures during early childhood: a population-based cohort study.

Clin Microbiol Infect 2020 Jun 4. Epub 2020 Jun 4.

Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114-1101, USA.

Objectives: Little is known about maturation of the airway microbiota during early childhood and the consequences of early-life antibiotic exposure.

Methods: In a population-based birth cohort of 902 healthy Finnish children, we applied deep neural network models to investigate the relationship between the nasal microbiota (measured by 16S rRNA gene sequencing at up to three time points) and child age during the first 24 months. We also performed stratified analyses according to antibiotic exposure during the age period 0-2 months. Read More

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http://dx.doi.org/10.1016/j.cmi.2020.05.033DOI Listing
June 2020
5.768 Impact Factor

Correlates of Sleep Duration in Early Childhood: A Systematic Review.

Behav Sleep Med 2020 Jun 4:1-19. Epub 2020 Jun 4.

Early Start, Faculty of Social Sciences, University of Wollongong , Australia.

Objective: This systematic review aimed to summarize correlates of sleep duration in children under 5 years of age.

Methods: Six electronic databases (PubMed, PsycINFO, MEDLINE, CINAHL, SPORTDiscus, and Scopus) were searched from inception to May 2019. Observational studies and intervention studies reporting cross-sectional results from baseline data were considered. Read More

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http://dx.doi.org/10.1080/15402002.2020.1772264DOI Listing

Presentation and Outcome of Acute Necrotizing Encephalopathy of Childhood: A 10-Year Single-Center Retrospective Study From Hong Kong.

J Child Neurol 2020 Jun 4:883073820927915. Epub 2020 Jun 4.

Department of Paediatrics and Adolescent Medicine, United Christian Hospital, Kwun Tong, Kowloon, Hong Kong SAR.

Acute necrotizing encephalopathy (ANE) is a rare disease in childhood. We reviewed the 10-year data from a local pediatric department, reported the clinical characteristics, laboratory tests, neuroimaging findings, and outcome of the acute necrotizing encephalopathy cases and identified the potential factors affecting the outcome. Eight episodes of acute necrotizing encephalopathy among 7 patients were recorded, in which all of them had an initial presentation of fever and seizure. Read More

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http://dx.doi.org/10.1177/0883073820927915DOI Listing

Maternal alcohol consumption during pregnancy associates with bone fractures in early childhood. A birth-cohort study of 6718 participants.

Bone 2020 May 30;137:115462. Epub 2020 May 30.

Department of Pediatric Surgery and Orthopaedics, Oulu University Hospital, PEDEGO-research unit and Medical Research Center, University of Oulu, Oulu, Finland.

Fractures are common injuries in children, but their underlying biological and environmental risk factors are not well known. Maternal alcohol consumption during pregnancy is a known risk factor for bone malformations and impaired growth, in connection with Fetal Alcohol Spectrum Disorders (FASD). There is evidence that even lower doses of alcohol than what is needed for FASD can cause changes in the developing bone. Read More

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http://dx.doi.org/10.1016/j.bone.2020.115462DOI Listing

Male Gonadal Function after Allogeneic Hematopoietic Stem Cell Transplantation in Childhood: A Cross-Sectional, Population-Based Study.

Biol Blood Marrow Transplant 2020 May 21. Epub 2020 May 21.

Division of Hematology-Oncology and Stem Cell Transplantation, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Pediatric Endocrinology Unit, Department of Women's and Children's Health, Karolinska Institute and University Hospital, Stockholm, Sweden. Electronic address:

Male gonadal dysfunction is a frequent late effect after pediatric hematopoietic stem cell transplantation (HSCT), but detailed insight into patterns of male gonadal function at long-term is limited by retrospective studies without semen sample data. In this study, we investigated the risk of azoospermia and testosterone deficiency, the diagnostic value of markers of spermatogenesis, and paternity at long-term follow-up after pediatric allogeneic HSCT. All male HSCT survivors age ≥18 years, transplanted in Denmark or Finland between 1980 and 2010, were invited to participate in this cross-sectional study. Read More

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http://dx.doi.org/10.1016/j.bbmt.2020.05.009DOI Listing

Hematogenous osteomyelitis in childhood can relapse many years later into adulthood: A retrospective multicentric cohort study in France.

Medicine (Baltimore) 2020 May;99(20):e19617

Service de Maladies Infectieuses et Tropicales, Hospices Civils de Lyon - Hôpital de la Croix-Rousse Lyon, Cedex 04.

To describe the epidemiological, clinical, laboratory, and radiological features and the management of adult patients who experienced a relapse between 2003 and 2015 of an acute hematogenous osteomyelitis acquired in childhood.A retrospective multicentric cohort study was conducted in 5 centers in France.Thirty-seven patients were included. Read More

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http://dx.doi.org/10.1097/MD.0000000000019617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254121PMC

Sacroiliitis associated with familial Mediterranean fever in childhood: a case series and review of literature.

Turk J Pediatr 2020 ;62(2):175-181

Divisions of Pediatric Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey.

Background And Objectives: Familial Mediterranean fever (FMF) is an autosomal-recessive auto-inflammatory disorder characterized by recurrent episodes of fever with serositis. Sacroiliitis associated with FMF is very rare, especially in children. We aimed to describe the demographic, clinical, laboratory features, and treatment responses of pediatric patients with FMF -related sacroiliitis. Read More

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http://dx.doi.org/10.24953/turkjped.2020.02.002DOI Listing
January 2020

Objective Estimates of Direct-Medical Costs Among Persons Aged 3 to 38 Years With and Without Research-Defined Autism Spectrum Disorder Ascertained During Childhood: A Population-Based Birth-Cohort Study.

Value Health 2020 May 27;23(5):595-605. Epub 2020 Feb 27.

Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.

Objectives: Accurate estimates of autism spectrum disorder (ASD)-associated medical costs are essential for predicting future care needs, allocating resources, identifying best practices, and modeling cost-effectiveness. Most existing studies have either employed subjective cost data or ascertained ASD using self-reported or International Classification of Diseases-coded diagnoses. Such ascertainment is especially problematic for identifying milder ASD among older individuals never diagnosed with ASD. Read More

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http://dx.doi.org/10.1016/j.jval.2019.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224581PMC

Clinical characterization of status epilepticus in childhood: a retrospective study in 124 patients.

Seizure 2020 May 17;78:127-133. Epub 2020 Apr 17.

Child Neurology and Psychiatry Unit, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy.

Purpose: The aim of this study is to describe demographic data, semiology and etiology in a pediatric population with status epilepticus (SE) and refractory SE (RSE).

Method: We retrospectively reviewed patients with the following inclusion criteria: i) age between two months and eighteen years; ii) SE diagnosis; iii) admission from January 2001 to December 2016; iv) available clinical data.

Results: We enrolled 124 patients. Read More

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http://dx.doi.org/10.1016/j.seizure.2020.03.019DOI Listing

The Relationship Between Perfluoroalkyl Substances Concentrations and Thyroid Function in Early Childhood: A Prospective Cohort Study.

Thyroid 2020 Jun 2. Epub 2020 Jun 2.

Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.

Exposure to perfluoroalkyl substances (PFAS) has been suggested to affect thyroid function; however, data on early-life exposure and thyroid function in early childhood are scarce. We investigated the cross-sectional and longitudinal relationships of early-life exposure to PFAS with thyroid function at 2, 4, and 6 years of age. This study used data on PFAS exposure and thyroid function from the Environment and Development of Children (EDC) cohort study. Read More

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http://dx.doi.org/10.1089/thy.2019.0436DOI Listing
June 2020
4.493 Impact Factor

VRK1 (Y213H) homozygous mutant impairs Cajal bodies in a hereditary case of distal motor neuropathy.

Ann Clin Transl Neurol 2020 May 4;7(5):808-818. Epub 2020 May 4.

Molecular Mechanisms of Cancer Program, Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Salamanca, Salamanca, Spain.

Background: Distal motor neuropathies with a genetic origin have a heterogeneous clinical presentation with overlapping features affecting distal nerves and including spinal muscular atrophies and amyotrophic lateral sclerosis. This indicates that their genetic background is heterogeneous.

Patient And Methods: In this work, we have identified and characterized the genetic and molecular base of a patient with a distal sensorimotor neuropathy of unknown origin. Read More

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http://dx.doi.org/10.1002/acn3.51050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261760PMC

Evolution of the Gut Microbiome in Early Childhood: A Cross-Sectional Study of Chinese Children.

Front Microbiol 2020 3;11:439. Epub 2020 Apr 3.

Shenzhen University Clinical Medical Academy, Shenzhen, China.

Temporal development of the human gut microbiome from infancy to childhood is driven by a variety of factors. We surveyed the fecal microbiome of 729 Chinese children aged 0-36 months, aiming to identify the age-specific patterns of microbiota succession, and evaluate the impact of birth mode, gender, geographical location, and gastrointestinal tract symptoms on the shaping of the gut microbiome. We demonstrated that phylogenetic diversity of the gut microbiome increased gradually over time, which was accompanied by an increase in and a reduction in species. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169428PMC

Correction: Anti-Müllerian hormone and Inhibin B after stem cell transplant in childhood: a comparison of myeloablative, reduced intensity and treosulfan-based chemotherapy regimens.

Bone Marrow Transplant 2020 Apr 24. Epub 2020 Apr 24.

Department of Molecular and Clinical Sciences, St George's University of London, Cranmer Terrace, London, SW17 0RE, UK.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

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http://dx.doi.org/10.1038/s41409-020-0914-5DOI Listing

The intergenerational transmission of mathematics achievement in middle childhood: A prospective adoption design.

Dev Sci 2020 Apr 23:e12974. Epub 2020 Apr 23.

Department of Psychology, The Pennsylvania State University, University Park, PA, USA.

The present study uses a parent-offspring adoption design to examine the dual roles of heritable and environmental influences on children's mathematics achievement. Linked sets (N = 195) of adopted children, adoptive parents, and birth parents each completed a measure of mathematics fluency (i.e. Read More

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http://dx.doi.org/10.1111/desc.12974DOI Listing

Self-Limiting Sternal Tumor of Childhood: A "Do Not Touch" Lesion.

J Pediatr 2020 Jun 17;221:260-261. Epub 2020 Apr 17.

BP Diagnostic Medicine, Portuguese Beneficence of São Paulo, São Paulo, Brazil; Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

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http://dx.doi.org/10.1016/j.jpeds.2020.02.022DOI Listing

Childhood Emotional Incest Scale (CEIS): Development, validation, cross-validation, and reliability.

J Couns Psychol 2020 Apr 20. Epub 2020 Apr 20.

Department of Guidance and Counseling, Faculty of Education, Anadolu University.

Describing a maladaptive parent-child relationship wherein a parent turns to a child for the satisfaction of emotional and/or relational needs, emotional incest remains an underinvestigated phenomenon. This is partly due to a lack of an empirically based measure of childhood emotional incest, and as a result, a 2-factor, 12-item scale was created based on expert opinion and a preliminary study of 319 university students. Each consisting of 6 items, the factors were called "Surrogate Spouse" and "Unsatisfactory Childhood. Read More

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http://dx.doi.org/10.1037/cou0000439DOI Listing

Cerebral cavernous malformation presenting in childhood: a single-centered surgical experience of 29 cases.

Clin Neurol Neurosurg 2020 Jul 10;194:105830. Epub 2020 Apr 10.

Department of Neurosurgery, Gazi University Faculty of Medicine, Ankara, Turkey.

Objectives: Cerebral cavernous malformations (CMs) are benign vascular hamartomas of central nervous system. Although they are mostly asymptomatic, they may occasionally result in life-threatening complications leading to surgical treatment. The main goal is to evaluate the surgical outcomes of operated pediatric cerebral CMs in our clinic and compare our results with the literature. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.105830DOI Listing

Air pollution from industries and asthma onset in childhood: A population-based birth cohort study using dispersion modeling.

Environ Res 2020 Jun 25;185:109180. Epub 2020 Jan 25.

Institut National de Sante Publique du Quebec (INSPQ), Montreal, Quebec, Canada; University of Montreal, Public Health Research Center, Montreal, Quebec, Canada. Electronic address:

Background: Despite evidence that ambient air pollution may play a role in the development of asthma, little is known about the potential contribution of industrial emissions.

Objective: We used a population-based birth cohort to investigate the association between asthma onset in childhood and residential exposure to industrial emissions, estimated from atmospheric dispersion modeling.

Methods: The study population comprised all children born in the province of Quebec, Canada, 2002-2011. Read More

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http://dx.doi.org/10.1016/j.envres.2020.109180DOI Listing

Bidirectional relationships between appetitive behaviours and body mass index in childhood: a cross-lagged analysis in the Generation XXI birth cohort.

Eur J Nutr 2020 Apr 9. Epub 2020 Apr 9.

EPIUnit-Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal.

Purpose: Appetitive behaviours have been associated with body mass index (BMI). However, existing data were largely derived from cross-sectional studies and cannot provide insight into the direction of associations. We aimed to explore the bidirectionality of these associations in school-age children. Read More

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http://dx.doi.org/10.1007/s00394-020-02238-9DOI Listing

Birth by Caesarean section and otitis media in childhood: a retrospective cohort study.

Sci Rep 2020 Mar 23;10(1):5219. Epub 2020 Mar 23.

Perinatal Epidemiology Research Unit, Depts of Obstetrics & Gynaecology and Pediatrics, Dalhousie University, Halifax, NS, Canada.

The objective of the present study was to examine the association between birth by Caesarean section (CS) and otitis media (OM) in childhood. We assembled a retrospective cohort of children born between 2003 and 2007 in Nova Scotia and followed them through to 2014. The cohort was derived through a linkage of the Nova Scotia Atlee Perinatal Database with provincial administrative health data. Read More

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http://dx.doi.org/10.1038/s41598-020-62229-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090017PMC

Anti-Müllerian hormone and Inhibin B after stem cell transplant in childhood: a comparison of myeloablative, reduced intensity and treosulfan-based chemotherapy regimens.

Bone Marrow Transplant 2020 Mar 30. Epub 2020 Mar 30.

Department of Molecular and Clinical Sciences, St George's University of London, Cranmer Terrace, London, SW17 0RE, UK.

Serum concentrations of Anti-Müllerian hormone (AMH) and Inhibin B were used to assess potential fertility in survivors of childhood haematopoietic stem cell transplantation (HSCT) after three chemotherapy-conditioning regimens of differing intensity. Of 428 patients transplanted between 1990-2012 for leukaemia and immunodeficiency 121 surviving >1 year after a single HSCT were recruited. Group A had a treosulfan-based regimen (low-toxicity); Group B had fludarabine/melphalan (Flu-Mel) (reduced-intensity) and Group C had busulphan/cyclophosphamide (Bu-Cy) (myelo-ablative). Read More

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http://dx.doi.org/10.1038/s41409-020-0866-9DOI Listing

Psoriatic arthritis in childhood: A commentary on the controversy.

Clin Immunol 2020 May 27;214:108396. Epub 2020 Mar 27.

Department of Pediatrics, Program in Immunology, Stanford University, 269 Campus Drive, CCSR Rm 2105c, Stanford, CA 94305-5164, USA. Electronic address:

Approximately 5% of children with juvenile idiopathic arthritis (JIA) are diagnosed with the psoriatic form of the disease. In recent years, there has been substantial scholarship demonstrating both heterogeneity within the disease as well as similarities with other forms of JIA, culminating in a recent proposal for the categorization of JIA that excluded the psoriatic form altogether. The purpose of the review is to summarize the clinical, epidemiologic, and genetic features of psoriatic JIA (PsJIA), comparing it with other categories of JIA including spondyloarthritis. Read More

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http://dx.doi.org/10.1016/j.clim.2020.108396DOI Listing

Renal Tumors of Childhood-A Histopathologic Pattern-Based Diagnostic Approach.

Cancers (Basel) 2020 Mar 19;12(3). Epub 2020 Mar 19.

Princess Máxima Center for pediatric oncology, 3584 CS Utrecht, The Netherlands.

Renal tumors comprise approximately 7% of all malignant pediatric tumors. This is a highly heterogeneous group of tumors, each with its own therapeutic management, outcome, and association with germline predispositions. Histopathology is the key in establishing the correct diagnosis, and therefore pathologists with expertise in pediatric oncology are needed for dealing with these rare tumors. Read More

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http://dx.doi.org/10.3390/cancers12030729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140051PMC

Predictors of Bicuspid Aortic Valve-Associated Aortopathy in Childhood: A Report From the MIBAVA Consortium.

Circ Cardiovasc Imaging 2020 03 17;13(3):e009717. Epub 2020 Mar 17.

Division of Cardiology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Canada (M.G., R.R., C.M., S.M., Ch.-P.S.F., C.M., L.M.).

Background: Bicuspid aortic valve (BAV) is the most prevalent congenital heart defect affecting 1% to 2% of the population. It is associated with ascending aorta dilatation. Valve morphology, aortic stenosis (AS), and aortic insufficiency (AI) have been proposed as potential risk factors; however, evaluating their role is difficult, as these factors are inherently related. Read More

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http://dx.doi.org/10.1161/CIRCIMAGING.119.009717DOI Listing

Prenatal antidepressant exposures and gastrointestinal complaints in childhood: A gut-brain axis connection?

Dev Psychobiol 2020 Mar 13. Epub 2020 Mar 13.

Department of Psychology, Emory University, Atlanta, GA, USA.

Selective serotonin/norepinephrine reuptake inhibitors (collectively, SRIs) are the most commonly prescribed antidepressant agents for the treatment of depression in pregnancy. SRIs affect maternal and placental serotonin signaling, which might impact fetal brain development. Alterations in serotonin signaling might also impact the developing gut-brain axis (GBA) via alterations in the fetal enteric nervous system (ENS). Read More

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http://dx.doi.org/10.1002/dev.21966DOI Listing

"Food" and "non-food" self-regulation in childhood: a review and reciprocal analysis.

Int J Behav Nutr Phys Act 2020 03 10;17(1):33. Epub 2020 Mar 10.

College of Education, Psychology and Social Work, Flinders University, Sturt Rd, Bedford Park, South Australia, 5042, Australia.

Background: In developmental science, there is an extensive literature on non-food related self-regulation in childhood, where several domains relating to emotions, actions and cognitions have been identified. There is now growing attention to food related self-regulation in childhood, especially difficulties with ASR, and the consequences for weight gain and adiposity. The aim of this narrative review was to conduct a reciprocal analysis of self-regulation in the food and non-food domains in childhood (referred to as appetite self-regulation (ASR) and general self-regulation (GSR) respectively). Read More

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http://dx.doi.org/10.1186/s12966-020-00928-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063723PMC

Ménétrier's disease in childhood: a case report from China.

BMC Pediatr 2020 Mar 6;20(1):110. Epub 2020 Mar 6.

Department of Gastroenterology, Hepatology, and Nutrition, Shanghai Children's Hospital, Shanghai Jiao Tong University, 355 Luding Road, Shanghai, 200062, China.

Background: Ménétrier's disease (MD) is a protein-losing gastropathy characterized by gastric hypertrophy, foveolar hyperplasia and hypoalbuminemia. MD is uncommon in childhood with nonspecific clinical symptoms, and the exact cause of pediatric MD is still unclear.

Case Presentation: Here, we reported a 4 year and 10-month boy presenting with MD from China. Read More

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http://dx.doi.org/10.1186/s12887-020-2005-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059724PMC

Endoscopic endonasal resection of congenital trans-sphenoidal meningoencephalocele with extension to the epipharynx in early childhood: a case report.

Afr Health Sci 2019 Sep;19(3):2764-2767

Department of Neurosurgery, Faculty of Medicine, Medical University-Plovdiv, Bulgaria.

Background: The clinical presentation of sphenoid sinus meningoencephaloceles (MEC) may have insidious onset and evolution. Contemporary treatment incorporates endoscopic resection via the endonasal route.

Case Description: We present a case of 3 year old girl who had been complaining of permanent nasal discharge, impeded nasal breathing and difficulty with feeding since she was 5 months old. Read More

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http://dx.doi.org/10.4314/ahs.v19i3.52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040274PMC
September 2019

Magnetic resonance imaging volumetric analysis in patients with Alternating hemiplegia of childhood: A pilot study.

Eur J Paediatr Neurol 2020 May 13;26:15-19. Epub 2020 Feb 13.

Division of Pediatric Neurology, Department of Pediatrics, Duke University Medical Center, T0913 Children's Health Center, DUMC Box 3936, Durham, NC, 27710, USA. Electronic address:

Quantitative MRI is increasingly being used as a biomarker in neurological disorders. Cerebellar atrophy occurs in some Alternating Hemiplegia of Childhood (AHC) patients. However, it is not known if cerebellar atrophy can be a potential biomarker in AHC or if quantitative MRI is a reliable method to address this question. Read More

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http://dx.doi.org/10.1016/j.ejpn.2020.02.001DOI Listing

A decade of sun protection in Australian early-childhood services: analysis of cross-sectional and repeated-measures data.

Health Educ Res 2020 Apr;35(2):99-109

Behavioural Research and Evaluation Unit, Cancer Council SA, 202 Greenhill Road, Eastwood, SA 5063, Australia.

Limiting ultraviolet radiation exposure during early childhood can significantly reduce the risk of developing skin cancer, making early childhood a critical time for sun protection strategies. This study aimed to measure sun protection practices utilized in Australian early-childhood services over the past decade and evaluate the impact of Cancer Council Australia's SunSmart Early-Childhood Program. Results are presented from cross-sectional and repeated-measures survey data, completed by directors or other staff at randomly sampled early-childhood services in 2008, 2013 and 2018 (N�=�3243). Read More

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http://dx.doi.org/10.1093/her/cyaa005DOI Listing

Temperament as a predictor of eating behavior in middle childhood - A fixed effects approach.

Appetite 2020 07 22;150:104640. Epub 2020 Feb 22.

Department of Psychology, Norwegian University of Science and Technology (NTNU), Dragvoll, 7491, Trondheim, Norway; Department of Child and Adolescent Psychiatry, St Olav's University Hospital, 7030, Trondheim, Norway.

Background: Individual differences in temperament are believed to influence the development of children's eating behavior. This hypothesis has predominantly been tested in cross-sectional designs and important confounders such as genetics and stable parenting factors have not been accounted for. The present study aims to establish more clearly than previous studies if temperament is involved in the etiology of eating behavior in middle childhood. Read More

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http://dx.doi.org/10.1016/j.appet.2020.104640DOI Listing

Cortical temporal hierarchy is immature in middle childhood.

Neuroimage 2020 Aug 11;216:116616. Epub 2020 Feb 11.

Neuroscience and Cognitive Science Program, University of Maryland, College Park, MD, USA; Department of Psychology, University of Maryland, College Park, MD, USA.

The development of successful social-cognitive abilities requires one to track, accumulate, and integrate knowledge of other people's mental states across time. Regions of the brain differ in their temporal scale (i.e. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2020.116616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299797PMC

Epileptic encephalopathy with features of rapid-onset dystonia Parkinsonism and alternating hemiplegia of childhood: a novel combination phenotype associated with ATP1A3 mutation.

Epileptic Disord 2020 Feb;22(1):103-109

Department of Pediatrics, Duke University Medical Center.

Mutations in ATP1A3 have been found to cause rapid-onset dystonia Parkinsonism, alternating hemiplegia of childhood, epileptic encephalopathy and other syndromes. We report a four-year, nine-month-old boy with episodes of frequent and recurrent status epilepticus, who first began having generalized tonic-clonic seizures at four months of age. Development was normal until the age of four months, and markedly slowed down after the onset of seizures. Read More

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http://dx.doi.org/10.1684/epd.2020.1127DOI Listing
February 2020

EBV-positive T/NK-associated lymphoproliferative disorders of childhood: A complete autopsy report.

Indian J Pathol Microbiol 2020 Jan-Mar;63(1):78-82

Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada, N6A 5C1; Department of Pathology and Laboratory Medicine, London Health Sciences Centre, London, Ontario, Canada, N6A 5A5, Canada.

Introduction: Epstein-Barr Virus (EBV)-associated systemic T-cell lymphoproliferative disorder of childhood is a rare but severe manifestation of chronic EBV infection. Despite several case reports characterizing this rare hematological neoplasm, the literature describes extensive heterogeneity in the presentation of this disease.

Case Presentation: Here we present a complete autopsy of a 16-year-old girl who ultimately succumbed to EBV-associated systemic T-cell lymphoproliferative disorder of childhood. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_510_19DOI Listing
February 2020

Behavioral intervention for sleep problems in childhood: a Brazilian randomized controlled trial.

Psicol Reflex Crit 2019 Jan 28;32(1). Epub 2019 Jan 28.

Universidade de São Paulo. Avenida. Prof. Mello Moraes, 1721. Butantã, São Paulo, SP, 05508030, Brazil.

Background: Sleep problems are common in children and can have an effect on behavioral and emotional functioning. Despite the importance of sleep for children's health, there is a lack of studies on this topic in Brazil. The aim of this study was to evaluate the efficacy of behavioral intervention for sleep problems in young children and to investigate the effects on their daytime behavior. Read More

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http://dx.doi.org/10.1186/s41155-019-0118-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6967177PMC
January 2019

Transitions between socio-emotional and cognitive vulnerability profiles from early to middle childhood: a population study using multi-agency administrative records.

Eur Child Adolesc Psychiatry 2020 Feb 4. Epub 2020 Feb 4.

Neuroscience Research Australia (NeuRA), Sydney, Australia.

Adult psychosocial difficulties, including psychiatric disorders, are often preceded by childhood psychosocial vulnerabilities, presenting critical windows of opportunity for preventative intervention. The present study aimed to identify longitudinal patterns (representing transitions between profiles) of childhood socio-emotional and cognitive vulnerability in the general population from early to middle childhood, in relation to key risk factors (e.g. Read More

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http://dx.doi.org/10.1007/s00787-020-01475-xDOI Listing
February 2020

Medical Cannabis for Intractable Epilepsy in Childhood: A Review.

Authors:
Bruria Ben-Zeev

Rambam Maimonides Med J 2020 Jan 30;11(1). Epub 2020 Jan 30.

Pediatric Neurology Department, The Edmond and Lilly Safra Pediatric Hospital, Sheba Medical Center, Tel Hashomer, Israel.

In recent years, cannabis has been gaining increasing interest in both the medical research and clinical fields, with regard to its therapeutic effects in various disorders. One of the major fields of interest is its role as an anticonvulsant for refractory epilepsy, especially in the pediatric population. This paper presents and discusses the current accumulated knowledge regarding artisanal cannabis and Epidiolex®, a United States Food and Drug Administration (FDA)-approved pure cannabidiol (CBD), in epilepsy management in pediatrics, by reviewing the literature and raising debate regarding further research directions. Read More

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http://dx.doi.org/10.5041/RMMJ.10387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000162PMC
January 2020

Socioeconomic disadvantage and health in early childhood: a population-based birth cohort study from Portugal.

Pediatr Res 2020 Jan 31. Epub 2020 Jan 31.

EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.

Background: Measuring early socioeconomic inequalities in health provides evidence to understand the patterns of disease. Thus, our aim was to determine which children's health outcomes are patterned by socioeconomics and to what extent the magnitude/direction of the differences vary by socioeconomic measure and outcome.

Methods: Data on early childhood (4 years) health was obtained from Generation XXI birth cohort (n = 8647). Read More

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http://dx.doi.org/10.1038/s41390-020-0786-9DOI Listing
January 2020

Optic neuropathies in childhood: a review of etiology and treatment.

Turk J Pediatr 2019 ;61(4):471-476

Division of Pediatric Neurology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Günbey C, Konuşkan B. Optic neuropathies in childhood: a review of etiology and treatment. Turk J Pediatr 2019; 61: 471-476. Read More

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http://dx.doi.org/10.24953/turkjped.2019.04.001DOI Listing

Type 1 diabetes mellitus and educational attainment in childhood: a systematic review.

BMJ Open 2020 01 26;10(1):e033215. Epub 2020 Jan 26.

Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK

Objectives: The primary objective of this systematic review was to evaluate available literature on whether type 1 diabetes mellitus (T1DM) has an impact on educational attainment in individuals undertaking high stakes standardised testing at the end of compulsory schooling.

Design: A systematic review was undertaken comparing educational attainment for individuals with and without T1DM who have undertaken high stakes testing at the end of compulsory schooling.

Data Sources: A comprehensive search of MEDLINE, MEDLINE (epub ahead of print, in-process and other non-indexed citations), EMBASE, Web of Science, British Education Index, Education Resources Information Center and Cumulative Index to Nursing and Allied Health Literature was undertaken on 15 January 2018 and updated on 17 January 2019. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-033215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045136PMC
January 2020

Evaluating body composition in infancy and childhood: A comparison between 4C, QMR, DXA, and ADP.

Pediatr Obes 2020 06 27;15(6):e12617. Epub 2020 Jan 27.

Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Background: Accurate and precise methods to measure of body composition in infancy and childhood are needed.

Objectives: This study evaluated differences and precision of three methods when compared with the four-compartment (4C) model for estimating fat mass (FM).

Methods: FM of children (age 14 days to 6 years of age, N = 346) was obtained using quantitative nuclear magnetic resonance (QMR, EchoMRI-AH), air-displacement plethysmography (ADP, PeaPod, less than or equal to 8 kg, BodPod age 6 years or older), and dual-energy X-ray absorptiometry (DXA, Hologic QDR). Read More

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http://dx.doi.org/10.1111/ijpo.12617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323309PMC

Efficacy and Safety of Sodium Benzoate in The Management of Hyperammonemia in Decompensated Chronic Liver Disease of the Childhood-A Double-blind Randomized Controlled Trial.

J Pediatr Gastroenterol Nutr 2020 Feb;70(2):165-170

Department of Pediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.

Objective: The objective was to evaluate the efficacy and safety of sodium benzoate in the management of hyperammonemia and hepatic encephalopathy (HE) in decompensated chronic liver disease.

Methods: It was a prospective, interventional, double-blinded randomized controlled trial conducted from August 2017 to December 2018. Children with decompensated chronic liver disease and hyperammonemia were included in the study. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002521DOI Listing
February 2020