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J Genet Psychol 2022 Mar-May;183(3):250-262. Epub 2022 Mar 31.

Department of Counselling, Faculty of Education and Psychology, Alzahra University, Tehran, Iran.

Migraine, which is a highly prevalent headache, is often comorbid with alexithymia. Parental styles contribute to the development of alexithymia. The core psychological mechanisms that connect parenting to alexithymia and can be targeted in psychotherapy are not yet studied. Read More

Behav Sci (Basel) 2022 Jan 28;12(2). Epub 2022 Jan 28.

Department of Psychology, University of Jaén, 23071 Jaén, Spain.

Headache is the first cause of consultation in neurology, and one of the most frequent reasons for consultation in general medicine. Migraine is one of the most common, prevalent, and socioeconomically impactful disabling primary headache disorders. Neuroticism can be conceptualized as a disposition to suffer anxiety and emotional disorders in general. Read More

Headache 2022 03 9;62(3):223-224. Epub 2022 Feb 9.

University of Toledo College of Medicine & Life Sciences, Toledo, Ohio, USA.

Eur J Paediatr Neurol 2022 Mar 3;37:68-74. Epub 2022 Feb 3.

Child Neuropsychiatry Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.

Introduction: The goal of the present study was to comparatively analyze Social Cognition skills in a pediatric population diagnosed with Migraine or Epilepsy, compared to Typically Developing children (TD). The secondary aim was to relate Social Cognition skills with other migraine- or epilepsy-related variables and with executive and cognitive functions.

Materials And Methods: In our cross-sectional observational study 119 children and adolescents (aged 6-16) with Migraine or Focal Epilepsy and 61 TD peers were recruited. Read More

Headache 2022 Mar 5;62(3):319-328. Epub 2022 Feb 5.

Departments of Pediatrics, Community Health Sciences, and Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Background: Adverse childhood experiences (ACEs) are cross-sectionally associated with headache, including migraine, in pediatric populations.

Objective: The objective of this study was to determine whether ACEs are prospectively associated with incident health-professional diagnosed migraine and prevalence of non-migraine frequent headache in adolescence, either directly or indirectly through symptoms of depression and anxiety.

Methods: We used data from the National Longitudinal Survey of Children and Youth, a Canadian cohort study that followed children aged 0/1 at baseline, and the person most knowledgeable about them (PMK) until the child reached adolescence. Read More

Wounds 2021 12;33(12):E90-E92

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.

In countries other than the United States, the BCG vaccine is typically used as a method for preventing childhood tuberculosis; in the United States, the BCG vaccine has gained popularity as a speculated therapy for autoimmune and inflammatory disorders. Research suggests that the vaccine can train the innate immune response, thereby improving symptoms of disorders such as diabetes and fibromyalgia. However, the potential side effects associated with the use of this vaccine are not totally innocuous. Read More

J Integr Complement Med 2022 Feb 28;28(2):114-123. Epub 2022 Jan 28.

Department of Cardiology, Memphis VA Medical Center, Memphis, TN, USA.

Accumulated evidence garnered in the last few decades has highlighted the role of yoga in health and disease. The overwhelming mortality and morbidity mediated by noncommunicable epidemics such as heart disease and cancer have fostered a search for mechanisms to attenuate them. Despite overwhelming success in acute care, the efficacy of modern medicines has been limited on this front. Read More

Curr Pain Headache Rep 2022 Feb 22;26(2):151-163. Epub 2022 Jan 22.

Consultant in Pediatric Neurology at the Israeli Albert Einstein Hospital, São Paulo, Brazil.

Purpose Of Review: To review the literature on the clinical characteristics of the symptoms other than headache that occurs during a migraine attack in childhood and adolescence.

Recent Findings: Premonitory symptoms (42-67%) and postdrome phase (82%) are frequent. The most frequent auras were visual. Read More

Childs Nerv Syst 2022 03 21;38(3):619-626. Epub 2022 Jan 21.

Headache Outpatient Clinic, Hospital Sta Maria, North Lisbon University Hospital Centre, Neurology Department, Faculty of Medicine, University of Lisbon, Lisbon, Portugal.

Aim: To describe the natural history, evaluate the long-term prognosis, and identify predictors of a favorable outcome of childhood migraines in a cohort of children who had been diagnosed with migraine 25 years before.

Methods: One hundred eighteen children with headache (ages 2 to 15), observed in a headache outpatient clinic of a University Hospital in 1994, by one of the authors, were revaluated in 2019/2020 by a standardized telephone interview specifying headache characteristics, treatment, precipitants, and family history. Headache diagnosis at follow-up was based on ID-Migraine and confirmed by a semistructured interview. Read More

Neurol India 2021 Nov-Dec;69(6):1805-1807

Department of Neurology, Nalanda Medical College and Hospital, Patna, Bihar, India.

Ophthalmoplegic migraine (OM) also called recurrent painful ophthalmoplegic neuropathy (RPON) is not a so common disorder. It is characterized by childhood onset, ophthalmoplegia and migraine type of headache. The most common involved nerve is third cranial nerve. Read More

Life (Basel) 2021 Dec 12;11(12). Epub 2021 Dec 12.

Neurology Unit, Department of Neuroscience, Bambino Gesù Children Hospital, IRCCS, 00165 Rome, Italy.

Migraine is the first in order of frequency of the neurological disorders, affecting both adult and paediatric populations. It is also the first cause of primary headaches in children. Migraine equivalents are periodic disorders that can be associated with migraine or considered as prognostic features of a future migraine manifestation. Read More

J Clin Med 2021 Dec 15;10(24). Epub 2021 Dec 15.

Neuroscience Department, Bambino Gesù Children's Hospital IRCCS, Piazza di Sant'Onofrio 4, 00165 Rome, Italy.

Sleep disorders and primary headaches are frequent health problems in childhood, and they are often comorbid in an individual, linked by a mutual and complex relationship. This comorbidity is frequent and well-documented, but the available literature is usually biased in favor of one aspect or another, mainly depending on the expertise of the authors. The aim of this paper is to review existing literature on the diagnostic assessment of comorbid primary headaches and sleep disorders, so as to propose practical suggestions to accurately investigate the presence of comorbid conditions in children evaluated for primary headaches or for sleep disorders. Read More

Pediatr Int 2021 Dec 14. Epub 2021 Dec 14.

Bakircay University Cigli Training and Research Hospital, Department of Pediatrics, Division of Pediatric Neurology, Izmir, Turkey.

Background: Migraine is the primary cause of headache in childhood. Most of the patients can be treated with lifestyle changes and acute attack treatment. Prophylaxis should be considered when necessary, such as frequent absenses from school, poor quality of life, recurring emergency room visits and frequent analgesic use. Read More

Curr Pain Headache Rep 2021 Nov 11;25(11):69. Epub 2021 Nov 11.

Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Purpose Of Review: Understanding comorbidities in migraine is important because it can help us understand disease pathophysiology while also aiding the development of more effective treatment strategies. Additionally, it can provide greater awareness about appropriate diagnosis, the need for additional disease screening, and the natural history of migraine. Psychiatric comorbidities have been independently studied in both adults and children with migraine because their presentations can be distinct, and the physiology in these two groups can be different. Read More

Ann Indian Acad Neurol 2021 Jul-Aug;24(4):470-480. Epub 2021 May 11.

Department of Pediatrics (Neurology Division), Lady Hardinge Medical College and Kalawati Saran Children's Hospital, New Delhi, India.

Ketogenic dietary therapies (KDTs) have been in use for refractory paediatric epilepsy for a century now. Over time, KDTs themselves have undergone various modifications to improve tolerability and clinical feasibility, including the Modified Atkins diet (MAD), medium chain triglyceride (MCT) diet and the low glycaemic index treatment (LGIT). Animal and observational studies indicate numerous benefits of KDTs in paediatric neurological conditions apart from their evident benefits in childhood intractable epilepsy, including neurodevelopmental disorders such as autism spectrum disorder, rarer neurogenetic conditions such as Rett syndrome, Fragile X syndrome and Kabuki syndrome, neurodegenerative conditions such as Pelizaeus-Merzbacher disease, and other conditions such as stroke and migraine. Read More

Acta Med Port 2021 Jun 1;34(6):428-434. Epub 2021 Jun 1.

Serviço de Otorrinolaringologia e Cirurgia Cérvico-facial. Hospital de Braga. Braga. Portugal.

Introduction: Vestibular disorders in pediatric patients is still a controversial subject but has gained relevance over the years. In recent studies, its prevalence varied between 0.7% and 15%. Read More

J Trauma Dissociation 2022 May-Jun;23(3):245-278. Epub 2021 Oct 27.

Department of Psychology, National University of Ireland Galway, Galway, Ireland.

Migraine and chronic migraine are caused by a combination of modifiable and non-modifiable genetic, social, behavioral and environmental risk factors. Further research of possible modifiable risk factors for this headache disorder is merited, given its role as one of the leading causes of years lived with disability per year. The first aim of this online cross-sectional study was to investigate the psychosocial risk factors that predicted chronic migraine and severe migraine-related disability in 507 Irish and UK participants, focusing specifically on childhood maltreatment, attachment and tendency to dissociate, or experience depressed mood and/or anxiety. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Oct;35(10):865-869

The diagnostic criteria for "Vestibular Migraine of Childhood", "Probable Vestibular Migraine of Childhood" and "Recurrent Vertigo of Childhood" is put forth by the Committee for the Classification of Vestibular Disorders of the Bárány Society and the Migraine Classification subgroup of the International Headache Society at the beginning of 2021. It provides directions for the diagnosis and treatment of these syndromes to international community of pediatricians, otolaryngologists, neurologists, neurosurgeons, neuro-otologists physiotherapists, neurophysiologists, and audiologists. The paper concludes the current situation and research progress of diagnosis and treatment of children vertigo diseases. Read More

J Headache Pain 2021 Oct 2;22(1):114. Epub 2021 Oct 2.

Headache Science and Neurorehabilitation Center, IRCCS Mondino Foundation, Pavia, Italy.

Background: Monoclonal antibodies (mABs) targeting the calcitonin gene-related peptide (CGRP) pathway represent the first disease-specific preventive migraine therapy. Growing evidence suggests that they are effective in the preventive treatment of difficult-to-treat patients. In this study, we evaluated the psychological predictors of the outcome of treatment with the anti-CGRP monoclonal antibody erenumab in patients with chronic migraine (CM). Read More

Front Psychiatry 2021 26;12:687487. Epub 2021 Aug 26.

NAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary.

The role of circadian dysregulation is increasingly acknowledged in the background of depressive symptoms, and is also a promising treatment target. Similarly, stress shows a complex relationship with the circadian system. The gene, encoding a key element in circadian regulation has been implicated in previous candidate variant studies in depression with contradictory findings, and only a few such studies considered the interacting effects of stress. Read More

Neurogastroenterol Motil 2022 Mar 24;34(3):e14224. Epub 2021 Aug 24.

Unit of Pediatric Gastroenterology and Cystic Fibrosis Unit, Department of Human Pathology in Adulthood and Childhood ''G. Barresi'', University of Messina, Messina, Italy.

Background: Pediatric cyclic vomiting syndrome (CVS) is a little-known clinical condition, frequently diagnosed with delay. This study aims to describe the clinical presentation and management and to define possible predictive factors of the disease outcome.

Methods: In this retrospective study, all children who were diagnosed with CVS during the period 2010-2019 in three tertiary academic centers were included. Read More

Cephalalgia 2022 01 17;42(1):44-52. Epub 2021 Aug 17.

Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Objective: Identify preventive medication treatment response trajectories among youth participating in the Childhood and Adolescent Migraine Prevention study.

Methods: Data were evaluated from 328 youth (ages 8-17). Childhood and Adolescent Migraine Prevention study participants completed headache diaries during a 28-day baseline period and a 168-day active treatment period during which youth took amitriptyline, topiramate, or placebo. Read More

Rev Neurol (Paris) 2021 Sep 5;177(7):773-778. Epub 2021 Aug 5.

Department of Evaluation and Treatment of Pain, FHU INOVPAIN, la Timone Hospital, AP-HM, Marseille, France. Electronic address:

Four episodic syndromes are recognized in the current version of the International Classification of Headache Disorders (ICHD): cyclic vomiting syndrome (CVS); abdominal migraine; benign paroxysmal vertigo; benign paroxysmal torticollis. Previously called childhood periodic syndromes, they are thought to be early expressions of a migrainous spectrum. They usually occur in childhood or adolescence and some of these patients will develop migraine later in childhood or in adulthood. Read More

Otolaryngol Clin North Am 2021 Oct 23;54(5):973-987. Epub 2021 Jul 23.

Department of Audiology, Boys Town National Research Hospital, 555 N 30th St., Omaha, NE 68131, USA.

Dizziness occurs in children with an estimated prevalence of 0.45% to 15.0%. Read More

Epidemiol Psychiatr Sci 2021 Jul 15;30:e55. Epub 2021 Jul 15.

MOE-Shanghai Key Laboratory of Children's Environmental Health, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Aims: Maternal migraine may contribute to mental heath problems in offspring but empirical evidence has been available only for bipolar disorders. Our objective was to examine the association between maternal migraine and the risk of any and specific psychiatric disorders in offspring.

Methods: This population-based cohort study used individual-level linked Danish national health registers. Read More

JAMA Netw Open 2021 07 1;4(7):e2114788. Epub 2021 Jul 1.

Goldberg Migraine Program, Department of Neurology, David Geffen School of Medicine at University of California, Los Angeles.

JAMA Netw Open 2021 07 1;4(7):e2114712. Epub 2021 Jul 1.

Cincinnati Children's Headache Center, Cincinnati, Ohio.

Importance: Migraine is a common neurological disease that often begins in childhood and continues into adulthood; approximately 6 million children and adolescents in the United States cope with migraine, and many frequently experience significant disability and multiple headache days per week. Although pharmacological preventive treatments have been shown to offer some benefit to youth with migraine, additional research is needed to understand whether and how these benefits are sustained.

Objective: To survey clinical status of youth with migraine who participated in the 24-week Childhood and Adolescent Migraine Prevention (CHAMP) trial over a 3-year follow-up period. Read More