Search Our Scientific Publications & Authors

J Fr Ophtalmol 2022 Jun 23. Epub 2022 Jun 23.

Service d'ophtalmologie, CHU - Campus de Lomé, Lomé, Togo.

Introduction: Retinoblastoma is a curable cancer when management is early and prompt.

Objective: To describe the epidemiological, clinical and therapeutic aspects of retinoblastoma.

Materials And Methods: A retrospective study was carried out from January 2014 to December 2018 (5 years) at the department of ophthalmology in Campus-University Teaching Hospital, Lomé, Togo. Read More

JCO Glob Oncol 2022 Jun;8:e2200034

Division of Cancer Care and Epidemiology, Queen's University Cancer Research Institute, Kingston, Canada.

Purpose: Access to essential cancer medicines is a major determinant of childhood cancer outcomes globally. The degree to which pediatric oncologists deem medicines listed on WHO's Model List of Essential Medicines for Children (EMLc) essential is unknown, as is the extent to which such medicines are accessible on the front lines of clinical care.

Methods: An electronic survey developed was distributed through the International Society of Pediatric Oncology mailing list to members from 87 countries. Read More

Cancers (Basel) 2022 Jun 18;14(12). Epub 2022 Jun 18.

Department of Clinical Epidemiology and Biostatistics, Pontificia Universidad Javeriana, Bogotá 110231, Colombia.

Objectives: To describe the self-reported health problems and quality of life among adult-aged Colombian childhood and adolescent cancer survivors.

Methods: This is a descriptive cross-sectional study with Colombian childhood cancer survivors (CCS) who were diagnosed before the age of 18, at the moment of study were ≥18 years, and at least 5 years had passed since diagnosis. Each participant completed a self-reported study-specific online questionnaire along with the SF-36 Health Survey to assess the prevalence of health problems and current quality of life (QoL). Read More

Curr Oncol 2022 Jun 6;29(6):4104-4116. Epub 2022 Jun 6.

Université Paris Cité, INSERM, ECEVE, F-75010 Paris, France.

Background: Compared with the general population, childhood cancer survivors (CCS) could be at greater risk of psychological distress following the emergence of the COVID-19 pandemic.

Purpose: This cross-sectional study assessed the psychological consequences of COVID-19 on the mental health of CCS.

Design And Participants: In December 2020, we interviewed through an online self-report questionnaire, 580 5-year CCS participating in the French Childhood Cancer Survivor Study (FCCSS) cohort. Read More

Front Public Health 2022 6;10:780538. Epub 2022 Jun 6.

Department of Thoracic Oncology and Surgery, China State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background: Family socioeconomic position (SEP) in childhood is an important factor to predict some chronic diseases. However, the association between family SEP in childhood and the risk of lung cancer is not clear.

Methods: A systematic search was performed to explore their relationship. Read More

BMJ Open 2022 Jun 21;12(6):e057957. Epub 2022 Jun 21.

National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.

Objective: To identify aetiologies of childhood community-acquired pneumonia (CAP) based on a comprehensive diagnostic approach.

Design: 'Partnerships for Enhanced Engagement in Research-Pneumonia in Paediatrics (PEER-PePPeS)' study was an observational prospective cohort study conducted from July 2017 to September 2019.

Setting: Government referral teaching hospitals and satellite sites in three cities in Indonesia: Semarang, Yogyakarta and Tangerang. Read More

Eval Health Prof 2022 Jun 21:1632787221109309. Epub 2022 Jun 21.

School of Medicine, Department of Epidemiology and Biostatistics, Chao Family Comprehensive Cancer Center, 12219University of California, Irvine, CA, USA.

Posttraumatic growth (PTG) represents positive changes following a trauma, crisis, and/or psychologically distressing event. Experiencing cancer can serve as a traumatic event for patients, resulting in life changes among survivors. Various PTG measures have been used to assess post-cancer change among childhood cancer survivors (CCS), but few have been evaluated for use in this population. Read More

J Pediatr Hematol Oncol Nurs 2022 Jan-Feb;39(1):30-39

Department of Epidemiology and Biostatistics, Susan and Henry Samueli College of Health Sciences, 8788University of California, Irvine, Irvine, CA, USA.

Use of complementary and alternative medicine (CAM) by those undergoing cancer treatment is common. While some childhood cancer survivors (CCS) may use CAM to treat late effects, others may lack information about available alternative therapies. We sought to determine characteristics associated with seeking more information about CAM among an ethnically diverse sample of young adult CCS. Read More

JAMIA Open 2022 Jul 16;5(2):ooac049. Epub 2022 Jun 16.

National Cancer Institute, Bethesda, Maryland, USA.

Objectives: The International Classification of Childhood Cancer (ICCC) facilitates the effective classification of a heterogeneous group of cancers in the important pediatric population. However, there has been no development of machine learning models for the ICCC classification. We developed deep learning-based information extraction models from cancer pathology reports based on the ICD-O-3 coding standard. Read More

Lancet Child Adolesc Health 2022 Jul;6(7):445

Ital J Pediatr 2022 Jun 16;48(1):98. Epub 2022 Jun 16.

Center for Reproductive Medicine, Taihe Hospital, Hubei University of Medicine, No.32, South Renmin Road, Shiyan, 442000, China.

Background: Breastfeeding might prevent childhood cancer by stimulating the immune system.

Methods: The following databases, including PubMed, Embase, and Cochrane Library, were searched from inception to January 10, 2021.

Results: In dose-dependent manner, there was a statistically significant inverse association between any breastfeeding and the incidence of childhood cancer. Read More

Aliment Pharmacol Ther 2022 Jun 16. Epub 2022 Jun 16.

Department of Gastroenterology, Digestive Diseases Institute, CHU de Nantes, Nantes, France.

Background: Obesity is a growing global public health problem. More than half the European and North American population is overweight or obese. Colon and rectum cancers are still the second leading cause of cancer death worldwide, and epidemiological data support an association between obesity and colorectal cancers (CRCs). Read More

Eur J Cancer Prev 2021 12 30;31(Suppl 1):S7-S8. Epub 2021 Dec 30.

Specialist Medical Officer, ECH Hospital, Naraingarh, Ambala, Haryana, India.

Rev Col Bras Cir 2022 13;49:e20223273. Epub 2022 Jun 13.

- Hospital Pequeno Príncipe, Cirurgia Pediátrica - Curitiba - PR - Brasil.

Introduction: liver tumors are rare neoplasms in childhood (1-2%), and about 2/3 are malignant. Hepatoblastoma (HB) is the most frequent, followed by hepatocellular carcinoma (HCC). In both, the main treatment is surgical resection. Read More

mSphere 2022 Jun 15:e0019322. Epub 2022 Jun 15.

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

In October 2020, the National Cancer Institute (NCI) Serological Sciences Network (SeroNet) was established to study the immune response to COVID-19, and "to develop, validate, improve, and implement serological testing and associated technologies" (https://www.cancer.gov/research/key-initiatives/covid-19/coronavirus-research-initiatives/serological-sciences-network). Read More

J Adv Res 2022 Jun 11. Epub 2022 Jun 11.

Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. Electronic address:

Introduction: Cancer is the leading cause of death among children.

Objectives: We report on the latest estimates of the burden of cancer among children at the global, regional, and national levels from 1990 to 2019.

Methods: Based on the Global Burden of Disease Study 2019, children's cancer data were analyzed by sex, age, year, and location. Read More

Mutat Res Rev Mutat Res 2022 Jan-Jun;789:108415. Epub 2022 Mar 14.

University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.

Background: Among children, sex-specific differences in disease prevalence, age of onset, and susceptibility have been observed in health conditions including asthma, immune response, metabolic health, some pediatric and adult cancers, and psychiatric disorders. Epigenetic modifications such as DNA methylation may play a role in the sexual differences observed in diseases and other physiological traits.

Methods: We performed a meta-analysis of the association of sex and cord blood DNA methylation at over 450,000 CpG sites in 8438 newborns from 17 cohorts participating in the Pregnancy And Childhood Epigenetics (PACE) Consortium. Read More

Eur J Cancer 2022 Jul 8;170:209-235. Epub 2022 Jun 8.

Department of Medical Biometry, Informatics, and Epidemiology, University Hospital Bonn, Bonn, Germany.

Purpose: The available questionnaires for quality-of-life (QoL) assessments are age-group specific, limiting comparability and impeding longitudinal analyses. The comparability of measurements, however, is a necessary condition for gaining scientific evidence. To overcome this problem, we assessed the viability of harmonising data from paediatric and adult patient-reported outcome (PRO) measures. Read More

J Bone Miner Res 2022 Jun 10. Epub 2022 Jun 10.

MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.

Systemic inflammation is associated with reduced bone mineral density and may be influenced by pro-inflammatory diets. We undertook an observational analysis of associations between late pregnancy energy-adjusted Dietary Inflammatory Index (E-DII ) scores and offspring bone outcomes in childhood. E-DII scores (higher scores indicating pro-inflammatory diets) were derived from food frequency questionnaires in late pregnancy in two prospective mother-offspring cohorts: the Southampton Women's Survey (SWS) and the Avon Longitudinal Study of Parents and Children (ALSPAC). Read More

Pediatr Blood Cancer 2022 Jun 10:e29841. Epub 2022 Jun 10.

Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute; Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Background: We previously developed stakeholder-informed quality measures to assess end-of-life care quality for children with cancer. We sought to implement a subset of these quality measures in the multi-center pediatric palliative care (PPC) database.

Procedures: We utilized the Shared Data and Research database to evaluate the proportion of childhood cancer decedents from 2017-2021 who, in the last 30 days of life, avoided chemotherapy, mechanical ventilation, intensive care unit admissions, and > 1 hospital admission; were enrolled in hospice services, and reported ≤ 2 highly distressing symptoms. Read More

Clin J Pain 2022 07 1;38(7):484-491. Epub 2022 Jul 1.

Community Health and Epidemiology, Dalhousie University.

Objectives: Theoretical models suggest that anxiety, pain intensity, and pain catastrophizing are implicated in a cycle that leads to heightened fear of cancer recurrence (FCR). However, these relationships have not been empirically examined. The objective of this study was to examine the relationships between anxiety symptoms, pain intensity, pain catastrophizing, and FCR in childhood cancer survivors and their parents and to examine whether pain catastrophizing predicts increased FCR beyond anxiety symptoms and pain intensity. Read More

Cancers (Basel) 2022 Jun 3;14(11). Epub 2022 Jun 3.

Princess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands.

This study assessed sleep, distress and quality of life (QoL) in parents of children with acute lymphoblastic leukemia (ALL) from diagnosis to three years after, and the impact of sleep and distress on QoL. Additionally, this study explored determinants of sleep and distress. Parents completed the MOS Sleep, Distress Thermometer for Parents and SF-12 at four-five months (T0), one year (T1), two years (T2), and three years (T3) after diagnosis. Read More

Cancers (Basel) 2022 May 30;14(11). Epub 2022 May 30.

Centre for Big Data Research in Health, University of New South Wales, Sydney 2052, Australia.

The association between smoking and alcohol consumption and follicular lymphoma (FL) incidence and clinical outcome is uncertain. We conducted a population-based family case-control study (709 cases: 490 controls) in Australia. We assessed lifetime history of smoking and recent alcohol consumption and followed-up cases (median = 83 months). Read More

J Am Heart Assoc 2022 Jun 8;11(12):e024735. Epub 2022 Jun 8.

University of Alberta Edmonton Alberta Canada.

Background Determine the prevalence and predictors associated with underdiagnosis and undertreatment of modifiable cardiovascular disease (CVD) risk factors (hypertension, dyslipidemia, glucose intolerance/diabetes) among adult survivors of childhood cancer at high risk of premature CVD. Methods and Results This was a cross-sectional study of adult-aged survivors of childhood cancer treated with anthracyclines or chest radiotherapy, recruited across 9 US metropolitan regions. Survivors completed questionnaires and in-home clinical assessments. Read More

Cancer Med 2022 Jun 7. Epub 2022 Jun 7.

Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA.

Background: Synovial sarcoma (SS) accounts for 8%-10% of all soft-tissue sarcomas. Clinical presentation and outcomes vary, yet discrete risk groups based on validated prognostic indices are not defined for the full spectrum of patients with SS.

Methods: We performed a retrospective cohort study using data from the SEER (surveillance, epidemiology, and end results program) database of SS patients who were <70 years of age at diagnosis. Read More

Front Med (Lausanne) 2022 26;9:882727. Epub 2022 Apr 26.

Department of Radiation Molecular Epidemiology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.

With time after the Chernobyl accident, the number of papillary thyroid carcinomas (PTCs) driven by the BRAF oncoprotein is growing in patients exposed to radiation at a young age. Clinicopathological associations of BRAF in PTCs from patients with internal radiation history have not been sufficiently studied so far. This work analyzes the structural characteristics, proliferative activity, invasive features, clinical information, and dosimetric data in the BRAF-positive and BRAF-negative PTCs from the Ukrainian patients exposed to Chernobyl radiation and treated over 30 years after the accident. Read More

Aging Cell 2022 Jun 6:e13652. Epub 2022 Jun 6.

Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.

Accelerated aging is a hallmark of Down syndrome (DS), with adults experiencing early-onset Alzheimer's disease and premature aging of the skin, hair, and immune and endocrine systems. Accelerated epigenetic aging has been found in the blood and brain tissue of adults with DS but when premature aging in DS begins remains unknown. We investigated whether accelerated aging in DS is already detectable in blood at birth. Read More

J Orthop Surg Res 2022 Jun 3;17(1):300. Epub 2022 Jun 3.

Department of Pediatric Orthopedics, Shenzhen Children's Hospital of China Medical University, Shenzhen, Guangdong Province, People's Republic of China.

Background: Fractures are the most common type of unintentional injury in children, with traumatic upper limb fractures accounting for approximately 80% of all childhood fractures. Many epidemiological investigations of upper limb fractures in children have been conducted, but with the development of society, the patterns of childhood fractures may have changed. This study aimed to analyze the epidemiology and economic cost factors of upper limb fractures in Chinese children. Read More

Int J Cancer 2022 Jun 3. Epub 2022 Jun 3.

Medical Diagnostics Karolinska, Karolinska University Hospital, Stockholm, Sweden.

Risk of colorectal cancer (CRC) increases in relatives of patients with CRC. The extent to which this is attributable to genetic predisposition or shared environment is unclear. We explored this question using nationwide cohorts from Denmark, Finland and Sweden. Read More