122 results match your criteria Child neurology open[Journal]


Inhaled Solvent Abuse Mimicking Chronic Inflammatory Demyelinating Polyradiculoneuropathy.

Child Neurol Open 2020 Jan-Dec;7:2329048X20934914. Epub 2020 Jun 19.

Children's Hospital of Eastern Ontario Research Institute, University of Ottawa, Ontario, Canada.

Exposure to n-hexane or toluene-containing solvents such as glue or gasoline can produce clinical symptoms and neurophysiological findings that can mimic chronic inflammatory demyelinating polyneuropathy. The authors present a case of a boy with severe sensorimotor polyneuropathy with demyelinating features. Cerebrospinal fluid testing and magnetic resonance imaging spine did not show findings typical of chronic inflammatory demyelinating polyneuropathy. Read More

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http://dx.doi.org/10.1177/2329048X20934914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307582PMC

Parents' Assessment of Disability in Their Children With Down Syndrome.

Child Neurol Open 2020 Jan-Dec;7:2329048X20934248. Epub 2020 Jun 18.

Division of Child Neurology, Hans Christian Andersen Hospital for Children and Adolescents, Odense University Hospital, Odense, Denmark.

Aim: To describe a population of children with Down syndrome and evaluate their parents' assessment of disability.

Methods: Medical records of a population of 80 children with Down syndrome aged 5 to 17 years were analyzed for genetic background and associated diagnoses. And 27 parents to their children agreed to assess disability by employing a set of 26 International Classification of Functioning, Disability and Health body function (b) codes and activity and participation (d) codes. Read More

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http://dx.doi.org/10.1177/2329048X20934248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303779PMC

Do You See What I See? A Case of Alice in Wonderland Syndrome With EEG Correlate.

Child Neurol Open 2020 Jan-Dec;7:2329048X20932714. Epub 2020 Jun 12.

Division of Child and Adolescent Neurology, Department of Neurology, Mayo Clinic, Rochester, MN, USA.

Alice in Wonderland syndrome is a disorienting perceptual disorder characterized by discrete episodes of bizarre visual illusions and spatial distortions which has been associated with numerous neurologic and psychiatric conditions. Little is known regarding the electrophysiologic correlates of the visual symptoms described in this syndrome. The authors report the unique case of an 8-year-old boy presenting with visual distortions consistent with Alice in Wonderland syndrome, and an electroencephalogram demonstrating bilateral temporo-occipital slowing which correlated with symptoms of micropsia, teleopsia, and dysmorphopsia. Read More

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http://dx.doi.org/10.1177/2329048X20932714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294370PMC

Epilepsy and EEG Phenotype of SLC13A5 Citrate Transporter Disorder.

Child Neurol Open 2020 Jan-Dec;7:2329048X20931361. Epub 2020 Jun 8.

Division of Child Neurology, Department of Neurology, Stanford University School of Medicine, CA, USA.

Mutations in the SLC13A5 gene, a sodium citrate cotransporter, cause a rare autosomal recessive epilepsy (EIEE25) that begins during the neonatal period and is associated with motor and cognitive impairment. Patient's seizure burden, semiology, and electroencephalography (EEG) findings have not been well characterized. Data on 23 patients, 3 months to 29 years of age are reported. Read More

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http://dx.doi.org/10.1177/2329048X20931361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281881PMC

The Johns Hopkins Neurosciences Intensive Care Nursery Tenth Anniversary (2009-2019): A Historical Reflection and Vision for the Future.

Child Neurol Open 2020 Jan-Dec;7:2329048X20907761. Epub 2020 Mar 17.

Division of Neonatology, Department of Pediatrics, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA.

Since 2009, the Neurosciences Intensive Care Nursery at Johns Hopkins Childrens Center has provided a multidisciplinary approach toward the care of newborns with neurological disorders. The program's cornerstone is an interdisciplinary approach that involves the primary neonatology team plus experts from more than 10 specialties who convene at a weekly team conference at which newborns with neurological problems are discussed in detail. This interdisciplinary approach fosters in-depth discussion of clinical issues to optimize the management of neonates with neurological problems as well as the opportunity to generate research ideas and provide education about neonatal neuroscience at all levels (faculty, nurses, and trainees). Read More

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http://dx.doi.org/10.1177/2329048X20907761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081468PMC

An Unusual Etiology of Cerebellar Ataxia.

Child Neurol Open 2020 Jan-Dec;7:2329048X20907754. Epub 2020 Mar 17.

Department of Paediatrics, Medical College and Hospital, Kolkata, India.

Cerebellar ataxia, which is the lack of coordination, has a number of causes none of which are as uncommon or unheard of as Scrub typhus. Scrub typhus very rarely presents itself with CNS manifestations. Here, we present the case of a 7-year-old girl from the Hooghly district in West Bengal, who presented to us with the history of fever, cerebellar signs, and sudden onset of visual loss. Read More

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http://dx.doi.org/10.1177/2329048X20907754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081463PMC

Physical Therapy Intervention for a Child With Congenital Zika Virus Syndrome: A Case Report.

Child Neurol Open 2020 Jan-Dec;7:2329048X19896190. Epub 2020 Jan 6.

Unit for Physiotherapy Services, Trondheim Municipality, Norway.

No studies have described physical therapy treatment for children with congenital Zika virus syndrome. In this case report, the authors aimed to improve postural control, mobility, and social skills in a 17- to 18-month-old child with congenital Zika virus syndrome through a period of 6-week home-based, intensive physical therapy intervention. Outcome measures were the Posture and Postural Ability Scale, Pediatric Evaluation of Disability Inventory, and Caregiver Priorities and Child Health Index of Life With Disabilities. Read More

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http://dx.doi.org/10.1177/2329048X19896190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945451PMC
January 2020

Difficult Conversations.

Authors:
Alison Christy

Child Neurol Open 2019 4;6:2329048X19886723. Epub 2019 Nov 4.

Providence Health & Services, Portland, OR, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852347PMC
November 2019

Corrigendum to Development, Implementation, and Use of a Neurology Therapeutics Committee.

Authors:

Child Neurol Open 2019;6:2329048X19881550. Epub 2019 Sep 29.

[This corrects the article DOI: 10.1177/2329048X19830473.]. Read More

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http://dx.doi.org/10.1177/2329048X19881550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852350PMC
September 2019

A Novel SLC1A4 Mutation (p.Y191*) Causes Spastic Tetraplegia, Thin Corpus Callosum, and Progressive Microcephaly (SPATCCM) With Seizure Disorder.

Child Neurol Open 2019 8;6:2329048X19880647. Epub 2019 Oct 8.

Department of Paediatrics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates.

Spastic tetraplegia, thin corpus callosum, and progressive microcephaly is a recently described very rare autosomal recessive neurodevelopmental disorder. This disease was first described in 2015 in several families from the Ashkenazi Jewish ancestry with a founder mutation in (p.E256K) as the underlying genetic cause. Read More

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http://dx.doi.org/10.1177/2329048X19880647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852354PMC
October 2019

Intractable Generalized Epilepsy and Autosomal Dominant Hypocalcemia: A Case Report.

Child Neurol Open 2019 19;6:2329048X19876199. Epub 2019 Sep 19.

Division of Pediatric Neurology, University of Tennessee Health Science Center, Le Bonheur Children's Hospital Neuroscience Institute, Memphis, TN, USA.

Calcium-sensing receptor gain-of-function mutations are known to cause autosomal dominant hypocalcemia and independently an epilepsy syndrome. We report the unique case of a child with both intractable generalized epilepsy and a chronic abnormality in calcium homeostasis due to a calcium-sensing receptor gene mutation. She is a 16-year-old female who began having staring events around 3 years of age. Read More

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http://dx.doi.org/10.1177/2329048X19876199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852356PMC
September 2019

Lateral Medullary Syndrome Due to Left Vertebral Artery Occlusion in a Boy Postflexion Neck Injury.

Child Neurol Open 2019 6;6:2329048X19867800. Epub 2019 Aug 6.

Division of Pediatric Neurology, Departments of Pediatrics & Neurology/Neurosurgery, The Montreal Children's Hospital, McGill University, Montreal, Québec, Canada.

Lateral medullary syndrome is rare in pediatrics. It is characterized by neurological deficits due to an ischemic lesion in the lateral medulla. The authors describe a 17-year-old boy who developed lateral medullary syndrome in the context of a hyperflexion neck injury while diving in shallow water with traumatic vascular injury. Read More

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http://dx.doi.org/10.1177/2329048X19867800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852355PMC

Autonomic Cross-Innervation in Patients With Neurofibromatosis Type 2: Frey Syndrome and Unilateral Epiphora With Rhinorrhea.

Child Neurol Open 2019 6;6:2329048X19866617. Epub 2019 Aug 6.

Pediatric Hematology-Oncology, Department of Pediatrics, University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA.

The authors present 2 cases of cross-innervation in patients with neurofibromatosis type 2. In the first case, an iodine test was performed to demonstrate Frey syndrome in a 28-year-old female with neurofibromatosis type 2 who developed symptoms at age 10 years. The second patient is an 18-year-old female with neurofibromatosis type 2, 2 years status post left vestibular schwannoma subtotal resection who presented with paradoxical unilateral lacrimation and rhinorrhea triggered by heat stress and exercise. Read More

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http://dx.doi.org/10.1177/2329048X19866617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852346PMC

Metabolic Strokes in Propionic Acidemia: Transient Hemiplegic Events Without Encephalopathy.

Child Neurol Open 2019 3;6:2329048X19873242. Epub 2019 Sep 3.

Department of Neurology, Boston Children's Hospital, Boston, MA, USA.

Metabolic strokes are a notable feature associated with acute catabolic crises in patients with propionic acidemia. Despite their importance, these events are not well characterized. Here, we present the clinical history of a patient with propionic acidemia who developed 5 episodes of acute hemiparesis between 3 and 11 years of age. Read More

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http://dx.doi.org/10.1177/2329048X19873242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727095PMC
September 2019
2 Reads

Two Cases of Guillain-Barré Syndrome Variants Presenting With Dysautonomia.

Child Neurol Open 2019 16;6:2329048X19856778. Epub 2019 Jun 16.

Paediatric Neurology, Great Ormond Street Hospital for Children, London, United Kingdom.

We describe 2 pediatric cases presenting with posterior reversible encephalopathy syndrome secondary to autonomic dysfunction preceding the onset of motor symptoms in Guillain-Barré syndrome variants. Patient 1 presented acutely with encephalopathy, cerebellar signs, hypertension, lower limb weakness, and respiratory decompensation. Magnetic resonance imaging (MRI) brain showed occipital lesions consistent with posterior reversible encephalopathy syndrome. Read More

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http://dx.doi.org/10.1177/2329048X19856778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591518PMC
June 2019
8 Reads

Germinoma Mimicking Brain Inflammation: A Case Report.

Child Neurol Open 2019 20;6:2329048X19848181. Epub 2019 May 20.

Department of Neurology and Epileptology, Children's Memorial Health Institute, Warsaw, Poland.

The authors report a case of a germinoma of the brain in the child with symptoms restricted to central nervous system. Ten-year-old girl presented initially with sight deterioration, learning difficulties, abnormal behavior, polydipsia, and polyuria. Brain magnetic resonance examination revealed T2 hyperintensity of the corpus callosum, anterior commissure, and caudate nuclei. Read More

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http://dx.doi.org/10.1177/2329048X19848181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591517PMC
May 2019
6 Reads

2018 Reviewer Acknowledgment.

Authors:

Child Neurol Open 2019 11;6:2329048X19845262. Epub 2019 Apr 11.

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http://dx.doi.org/10.1177/2329048X19845262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591516PMC
April 2019
1 Read

Doublecortin Mutation in an Adolescent Male.

Child Neurol Open 2019 5;6:2329048X19836589. Epub 2019 May 5.

Department of Pediatric Neurology, John P. and Katherine G. McGovern Medical School, Houston, TX, USA.

Doublecortin (DCX) mutations cause abnormal development of the DCX protein that normally aids in neuronal migration during fetal development. These mutations lead to lissencephaly, or the appearance of a "smooth brain," which is varying levels of pachygyria or agyria in severe cases. Many genetic variants of the mutation have been identified, and an even greater range of phenotypic presentations have been described in the literature. Read More

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http://dx.doi.org/10.1177/2329048X19836589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591519PMC
May 2019
4 Reads

An Exploratory Electrical Stimulation Protocol in the Management of an Infant With Spina Bifida: A Case Report.

Child Neurol Open 2019 29;6:2329048X19835656. Epub 2019 Mar 29.

University of Maryland School of Medicine, Baltimore, MD, USA.

An infant with myelomeningocele and underdevelopment of the thoracic spinal cord was treated with 2 protocols of electrical stimulation: functional electrical stimulation and transcutaneous spinal cord electrical stimulation. The protocols were incorporated into the infant's outpatient early intervention home programs. Prior to initiation of electrical stimulation treatment at age 6 months, the infant exhibited complete loss of sensation below the level of T8 and muscular paralysis below the level of T10. Read More

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http://dx.doi.org/10.1177/2329048X19835656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589948PMC
March 2019
6 Reads

Long-Term Exposure and Safety of a Novel Topical Rapamycin Cream for the Treatment of Facial Angiofibromas in Tuberous Sclerosis Complex: Results From a Single-Center, Open-Label Trial.

Child Neurol Open 2019 14;6:2329048X19835047. Epub 2019 Apr 14.

Division of Pediatric Neurology, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA.

Facial angiofibromas, composed of fibrous tissue and blood vessels appearing on the face, are closely associated with tuberous sclerosis complex. Historically, oral rapamycin, a mammalian target of the rapamycin inhibitor of cell proliferation, has been used to treat visceral tuberous sclerosis-related tumors; however, the side effect profile of this medicine generally precludes its use in patients lacking significant internal involvement. The authors developed a novel topical formulation of rapamycin cream to treat the facial angiofibroma without exposing patients to possible systemic side effects. Read More

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http://dx.doi.org/10.1177/2329048X19835047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589944PMC
April 2019
8 Reads

Multiple Mitochondrial Dysfunctions Syndrome 4 Due to Gene Defects: A Review.

Authors:
Majid Alfadhel

Child Neurol Open 2019 7;6:2329048X19847377. Epub 2019 May 7.

Division of Genetics, Department of Pediatrics, King Abdullah International Medical Research Centre, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs (NGHA), Riyadh, Saudi Arabia.

Multiple mitochondrial dysfunctions syndrome 4, caused by gene defects (OMIM #616370), was first described by Al-Hassnan et al in 2015. To date, 20 cases have been reported: 13 females and 7 males from 18 different families. All cases are from Saudi Arabia except those from one Italian family. Read More

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http://dx.doi.org/10.1177/2329048X19847377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506909PMC
May 2019
4 Reads

De Novo Interstitial Deletion of 9q in a Pediatric Patient With Global Developmental Delay.

Child Neurol Open 2019 7;6:2329048X19844920. Epub 2019 May 7.

Department of Pediatric Neurology, Cohen Children's Medical Center at Northwell Health, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell.

Cytogenomic microarray (CMA) methodologies, including array comparative genomic hybridization (aCGH) and single-nucleotide polymorphism-detecting arrays (SNP-array), are recommended as the first-tier test for the evaluation of imbalances associated with intellectual disability, autism, and multiple congenital anomalies. The authors report on a child with global developmental delay (GDD) and a interstitial 7.0 Mb deletion of 9q21. Read More

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http://dx.doi.org/10.1177/2329048X19844920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506918PMC
May 2019
10 Reads

Spinal Cord Diffuse Midline Glioma in a 4-Year-Old Boy.

Child Neurol Open 2019 28;6:2329048X19842451. Epub 2019 Apr 28.

Division of Pediatric Neurology, University of Alabama, Birmingham, AL, USA.

Objective: We report a child presenting with spinal myelopathy secondary to H3K27M mutant diffuse midline glioma.

Case Report: A 4-year-old boy presented with a 3-week history of progressive gait difficulty. Examination revealed bilateral hand and lower extremity weakness, left leg hypertonia with ankle clonus, and a right hemisensory deficit. Read More

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http://journals.sagepub.com/doi/10.1177/2329048X19842451
Publisher Site
http://dx.doi.org/10.1177/2329048X19842451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488779PMC
April 2019
24 Reads

CLIPPERS Spectrum Disorder: A Rare Pediatric Neuroinflammatory Condition.

Child Neurol Open 2019 7;6:2329048X19831096. Epub 2019 Mar 7.

Department of Pathology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.

CLIPPERS (chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids) is a recently described, rare neuroinflammatory disorder diagnosed by clinical symptoms involving the brain stem with a distinct pattern on neuroimaging and a perivascular T-lymphocyte infiltrate on brain biopsy. It is a condition usually described in adults in the fourth to fifth decade. We report a case of 13-year-old Indian boy who presented with recurrent episodes of ataxia and diplopia with onset at 7 years of age. Read More

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http://dx.doi.org/10.1177/2329048X19831096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407169PMC
March 2019
3 Reads

Mutation Long-Term Follow-Up, With Decreased Brain -Acetylaspartic Acid and Secondary Mitochondrial Abnormalities.

Child Neurol Open 2019 21;6:2329048X19829520. Epub 2019 Feb 21.

Department of Medical Genetics and Pediatrics, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Aminoacyl transfer RNA (tRNA) synthetase complex-interacting multifunctional protein I is a noncatalytic component of tRNA multi-synthetase complexes. Although important in joining tRNAs to their cognate amino acids, AIMP1 has several other functions including axonal growth, cytokine activity, and interactions with -acetylaspartic acid in ribosomal tRNA synthetase complexes. Further, -acetylaspartic acid donates an aspartate during myelination and is therefore important to axonal integrity. Read More

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http://dx.doi.org/10.1177/2329048X19829520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388456PMC
February 2019
3 Reads

Glycine Transporter 1 Encephalopathy From Biochemical Pathway to Clinical Disease: Review.

Child Neurol Open 2019 19;6:2329048X19831486. Epub 2019 Feb 19.

King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard-Health Affairs (NGHA), Riyadh, Saudi Arabia.

Glycine transporter 1 encephalopathy (OMIM# 617301; glycine encephalopathy with normal serum glycine, GLYT1 transporter dysfunction, and nonketotic hyperglycinemia) is caused by mutations in the gene. To date, 6 cases have been reported in the literature, characterized as having neonatal onset, respiratory failure that required mechanical ventilation, severe hypotonia at birth that progressed to limb hypertonicity, and startle-like responses provoked by sudden loud noises and tactile stimulation. Additional characteristics included dysmorphic features, musculoskeletal abnormalities, and abnormal antenatal findings. Read More

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http://dx.doi.org/10.1177/2329048X19831486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383083PMC
February 2019

MRI-Negative Myelitis Associated With Myelin Oligodendrocyte Glycoprotein Antibody Spectrum Demyelinating Disease.

Child Neurol Open 2019 17;6:2329048X19830475. Epub 2019 Feb 17.

Division of Child and Adolescent Neurology, Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, TX, USA.

Myelin oligodendrocyte glycoprotein is expressed in the central nervous system on the surface of oligodendrocytes and is associated with a broad range of adult and pediatric demyelinating phenotypes. The entire spectrum of clinical and radiologic features of myelin oligodendrocyte glycoprotein antibody spectrum disorder remains to be fully elucidated. We describe the case of a 9-year-old boy with immune-mediated myelitis undetectable by conventional magnetic resonance imaging in the context of relapsing anti-myelin oligodendrocyte glycoprotein spectrum disorder. Read More

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http://dx.doi.org/10.1177/2329048X19830475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379793PMC
February 2019
8 Reads

Development, Implementation, and Use of a Neurology Therapeutics Committee.

Child Neurol Open 2019 14;6:2329048X19830473. Epub 2019 Feb 14.

Division of Pediatric Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.

Innovative therapeutics are transforming care of children with previously untreatable neurological disorders. However, there are challenges in the use of new therapies: the medicine may not be effective in all patients, administration may not be tolerated, and matching therapy choice to patient is complex. Finally, costs are high, which imposes financial burdens on insurance companies, families, and the health-care system. Read More

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http://dx.doi.org/10.1177/2329048X19830473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378459PMC
February 2019
3 Reads

A Not So Benign Family Pedigree With Hereditary Chorea: A Broader Phenotypic Expression or Additional Picture?

Child Neurol Open 2019 12;6:2329048X19828881. Epub 2019 Feb 12.

Department of Developmental Neuroscience, IRCCS Fondazione Stella Maris, Pisa, Italy.

mutations have been usually associated with a non-progressive neurological disease. Recent reports revealed a vast variability regarding its clinical expressivity. Aim of this work was widening the Benign Hereditary Chorea neurological, cognitive and behavioral phenotype through the description of a child and her family pedigree. Read More

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http://dx.doi.org/10.1177/2329048X19828881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376510PMC
February 2019
9 Reads

Acute Encephalopathy With Biphasic Seizures and Late Reduced Diffusion Associated With Adenoviral Pneumonia.

Child Neurol Open 2019 5;6:2329048X19826288. Epub 2019 Feb 5.

Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

Acute encephalopathy with biphasic seizures and late reduced diffusion is a subtype of acute encephalopathy described in a cohort of Japanese children. Few cases have been reported in countries other than Japan. It is characterized clinically by biphasic seizures and late reduced subcortical diffusion on magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.1177/2329048X19826288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365989PMC
February 2019
13 Reads

A Rare Case of Bartonella Encephalitis With Hemiplegia.

Child Neurol Open 2019 31;6:2329048X19826480. Epub 2019 Jan 31.

McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.

The authors describe a 12-year-old girl with an atypical presentation of encephalitis. She presented with fever and altered mental status and developed flaccid paralysis of her left upper extremity a day later. An electroencephalogram showed slowing over her right hemisphere. Read More

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http://journals.sagepub.com/doi/10.1177/2329048X19826480
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http://dx.doi.org/10.1177/2329048X19826480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360466PMC
January 2019
28 Reads

Autoimmune Ataxia During Maintenance Therapy for Acute Lymphoblastic Leukemia.

Child Neurol Open 2018 16;5:2329048X18819235. Epub 2018 Dec 16.

Division of Pediatric Hematology, Oncology & Bone Marrow Transplant, Department of Pediatrics, University of Wisconsin, Madison, WI, USA.

Neurologic dysfunction during acute lymphoblastic leukemia treatment is commonly associated with chemotherapy. Nonchemotherapy contributions should be considered for persistent atypical symptoms. We describe a boy with acute lymphoblastic leukemia who developed recurrent fevers, diarrhea, progressive ataxia, and neuropsychiatric impairment during maintenance chemotherapy. Read More

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http://dx.doi.org/10.1177/2329048X18819235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295710PMC
December 2018
3 Reads

Functional Gains in Children With Spastic Hemiplegia Following a Tendon Achilles Lengthening Using Computerized Adaptive Testing-A Pilot Study.

Child Neurol Open 2018 14;5:2329048X18811452. Epub 2018 Nov 14.

Shriners Hospitals for Children, Jefferson School of Health Professions, Thomas Jefferson University, Philadelphia, PA, USA.

Purpose: This pilot study evaluated the outcomes of tendon Achilles lengthening in 12 children (mean age: 11.2 years) with spastic hemiplegia.

Methods: Cerebral Palsy Computer Adaptive Tests, the timed up-and-go, the Gross Motor Function Measure, the Gillette Functional Assessment Questionnaire, and the Pediatric Outcomes Data Collection Instrument were administered at baseline and at 6, 12, and 24 months postsurgery. Read More

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http://journals.sagepub.com/doi/10.1177/2329048X18811452
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http://dx.doi.org/10.1177/2329048X18811452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238195PMC
November 2018
29 Reads

Impact of Transcranial Direct Current Stimulation on Reading Skills of Children and Adolescents With Dyslexia.

Child Neurol Open 2018 4;5:2329048X18798255. Epub 2018 Oct 4.

Department of Neuroscience and Mental Health, Medical School of Bahia, Federal University of Bahia, Salvador, Brazil.

Introduction: Rehabilitation techniques have been used to facilitate reading acquisition in dyslexia. However, many individuals continue to present academic impairment throughout life. New intervention strategies are necessary to further help this population. Read More

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http://journals.sagepub.com/doi/10.1177/2329048X18798255
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http://dx.doi.org/10.1177/2329048X18798255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174647PMC
October 2018
1 Read

Intensive Combination Immunotherapy and Neuroinflammation Resolution in a Child With Anti-PCA-1 (Yo) Paraneoplastic Syndrome and 2 Malignancies.

Child Neurol Open 2018 1;5:2329048X18795546. Epub 2018 Oct 1.

National Pediatric Myoclonus Center and National Pediatric Neuroinflammation Organization, Inc., Orlando, FL, USA.

Paraneoplastic cerebellar degeneration is rare and noteworthy in children. In this 7-year-old, it was documented to have occurred within a year of ataxia presentation. The instigating cancer was stage III adrenal adenocarcinoma, remitted after surgical resection at age 2. Read More

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http://journals.sagepub.com/doi/10.1177/2329048X18795546
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http://dx.doi.org/10.1177/2329048X18795546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168721PMC
October 2018
17 Reads

A Case With 4 de Novo Copy Number Variations With Clinical Features That Overlap 1q43q44 Microdeletion and 3q29 Microduplication Syndromes.

Child Neurol Open 2018 24;5:2329048X18798200. Epub 2018 Sep 24.

Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.

1q43q44 microdeletion syndrome is characterized by intellectual disability/global developmental delay, epilepsy, dysmorphic facies, stereotypic movement, language delay, recurrent infections, dental anomalies, and hand and foot anomalies. Microcephaly and corpus callosum dysplasia are present in some cases depending on gene content. 3q29 microduplication syndrome is characterized by intellectual disability, language delay, microcephaly, and dental anomalies. Read More

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http://dx.doi.org/10.1177/2329048X18798200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153526PMC
September 2018
7 Reads

Autism Spectrum Disorder and Neonatal Serum Magnesium Levels in Preterm Infants.

Child Neurol Open 2018 18;5:2329048X18800566. Epub 2018 Sep 18.

Division of Pediatric Neurology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.

Premature birth is associated with increased risk of autism spectrum disorder. Antenatal maternal magnesium administration is known to reduce subsequent risk of cerebral palsy including among premature infants, suggesting a potentially broader neuroprotective role for magnesium. Our objective was to determine whether magnesium could be protective against autism spectrum disorders in premature infants. Read More

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http://journals.sagepub.com/doi/10.1177/2329048X18800566
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http://dx.doi.org/10.1177/2329048X18800566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144497PMC
September 2018
7 Reads

A Retrospective Analysis of the Long-Term Outcome of Drug-Resistant Epilepsy in Children Treated in Urban India.

Child Neurol Open 2018 4;5:2329048X18795277. Epub 2018 Sep 4.

P.D. Hinduja National Hospital, Mumbai, India.

Objective: To study the outcome of childhood-onset drug-resistant epilepsy.

Methods: Fifty-five patients with drug-resistant epilepsy, meeting inclusion criteria, were identified from the Pediatric Neurology Clinic database with seizure onset less than age 13 years and a minimum follow-up of 5 years. Seizure remission was defined as no more than 1 seizure/year. Read More

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http://dx.doi.org/10.1177/2329048X18795277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124180PMC
September 2018
1 Read

A Case of Delayed-Onset Posthypoxic Leukoencephalopathy in a Pediatric Patient.

Child Neurol Open 2018 29;5:2329048X18792441. Epub 2018 Aug 29.

Division of Pediatric Intensive Care, Hasbro Children's Hospital, Providence, RI, USA.

We present a 16-year-old female status post traumatic brain injury from severe motor vehicle crash with prolonged extrication. Initially with a Glasgow Coma Scale of 4 and blood pressure of 80/40, she required emergent intubation. Head computed tomography was notable for skull fracture with hematoma, diffuse axonal injury, and 6-mm midline shift with right uncal herniation. Read More

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http://dx.doi.org/10.1177/2329048X18792441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116073PMC
August 2018
10 Reads

Atypical Rett Syndrome and Intractable Epilepsy With Novel Mutation.

Child Neurol Open 2018 23;5:2329048X18787946. Epub 2018 Aug 23.

Division of Neurology, The Ottawa Hospital Civic Campus, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1177/2329048X18787946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108011PMC
August 2018
33 Reads

Worster-Drought Syndrome Associated With Mutations.

Child Neurol Open 2018 2;5:2329048X18791083. Epub 2018 Aug 2.

Department of Genetics, Children's Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Ontario, Canada.

Worster-Drought syndrome is a congenital, pseudobulbar paresis. There is no identified molecular etiology despite familial cases reported. The authors report a boy who was diagnosed with Worster-Drought syndrome due to longstanding drooling, dysphagia, and impaired tongue movement. Read More

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http://journals.sagepub.com/doi/10.1177/2329048X18791083
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http://dx.doi.org/10.1177/2329048X18791083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077897PMC
August 2018
30 Reads

Novel Mutations Identified With Next-Generation Sequencing Expand the Spectrum of PLP1-Associated Leukodystrophy Clinical Phenotypes.

Child Neurol Open 2018 23;5:2329048X18789282. Epub 2018 Jul 23.

Pediatric Motor Disorders Research Program, Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.

Next-generation sequencing was performed for 2 families with an undiagnosed neurologic disease. Analysis revealed X-linked mutations in the () gene, which is associated with X-linked Pelizaeus-Merzbacher disease and Spastic Paraplegia type 2. In family A, the novel missense mutation c. Read More

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http://dx.doi.org/10.1177/2329048X18789282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056774PMC
July 2018
24 Reads

A Gut Feeling: A Hypothesis of the Role of the Microbiome in Attention-Deficit/Hyperactivity Disorders.

Child Neurol Open 2018 11;5:2329048X18786799. Epub 2018 Jul 11.

Department of Surgery, Rowan University School of Osteopathic Medicine, Stratford, NJ, USA.

Attention-deficit/hyperactivity disorder (ADHD) is a neurologic disorder characterized by hyperactivity/impulsivity and/or inattentiveness, with genetic and environmental factors contributing to the disorder. With the growing recognition of the microbiome's role in many neurological disorders, the authors propose that it may also be implicated in ADHD. Here, we describe several evolving areas of research to support this hypothesis. Read More

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http://dx.doi.org/10.1177/2329048X18786799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047248PMC
July 2018
2 Reads

Vibration-Assisted Home Training Program for Children With Spinal Muscular Atrophy.

Child Neurol Open 2018 10;5:2329048X18780477. Epub 2018 Jun 10.

Children's and Adolescent's Hospital, University of Cologne, Cologne, Germany.

The aim of this study was to determine the effect of a new method of vibration-assisted neuromuscular rehabilitation in patients with spinal muscular atrophy types II and III. In this retrospective observational study, 38 children (mean age: 4.64 ± 1. Read More

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http://dx.doi.org/10.1177/2329048X18780477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024344PMC
June 2018
56 Reads

Afebrile Benign Convulsion Associated With Mild Gastroenteritis: A Cohort Study in a Tertiary Children Hospital.

Child Neurol Open 2018 1;5:2329048X18773498. Epub 2018 May 1.

Department of Pediatric Intensive Care Unit, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Benign convulsion with mild gastroenteritis is a new clinical entity that occurs in children who are otherwise healthy.

Method: This cohort study held among patients with afebrile convulsion and accompanying gastroenteritis in a tertiary children hospital during a 2-year period. Demographic and clinical data were analyzed. Read More

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http://dx.doi.org/10.1177/2329048X18773498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987894PMC
May 2018
38 Reads

Ketogenic Diet in Refractory Childhood Epilepsy: Starting With a Liquid Formulation in an Outpatient Setting.

Child Neurol Open 2018 29;5:2329048X18779497. Epub 2018 May 29.

Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Background: Ketogenic diet in children with epilepsy has a considerable impact on daily life and is usually adopted for at least 3 months. Our aim was to evaluate whether the introduction of an all-liquid ketogenic diet in an outpatient setting is feasible, and if an earlier assessment of its efficacy can be achieved.

Methods: The authors conducted a prospective, observational study in a consecutive group of children with refractory epilepsy aged 2 to 14 years indicated for ketogenic diet. Read More

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http://dx.doi.org/10.1177/2329048X18779497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977420PMC
May 2018
68 Reads

Biotin-Thiamine-Responsive Basal Ganglia Disease: Case Report and Follow-Up of a Patient With Poor Compliance.

Child Neurol Open 2018 26;5:2329048X18773218. Epub 2018 Apr 26.

Department of Pediatrics, King Abdulaziz Hospital, Ministry of National Guard, Al Ahsa, Saudi Arabia.

Background: Biotin-thiamine-responsive basal ganglia disease (BTBGD) is a rare treatable autosomal recessive neurometabolic disorder characterized by progressive encephalopathy that eventually leads to severe disability and death if not treated with biotin and thiamine supplements.

Objectives: We aimed to determine the optimal management of BTBGD presenting in acute encephalopathic episodes.

Method: Case report. Read More

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http://journals.sagepub.com/doi/10.1177/2329048X18773218
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http://dx.doi.org/10.1177/2329048X18773218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946631PMC
April 2018
32 Reads

Spinal Muscular Atrophy With Respiratory Distress Type 1-A Child With Atypical Presentation.

Child Neurol Open 2018 19;5:2329048X18769811. Epub 2018 Apr 19.

Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong SAR.

The authors report a child with spinal muscular atrophy with respiratory distress type 1 (SMARD1). She presented atypically with hypothyroidism and heart failure due to septal defects that required early heart surgery and microcephaly in association with cerebral atrophy and thin corpus collosum. The subsequent asymmetrical onset of diaphragmatic paralysis, persistent hypotonia, and generalized muscle weakness led to the suspicion of spinal muscular atrophy with respiratory distress type 1. Read More

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http://dx.doi.org/10.1177/2329048X18769811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946598PMC
April 2018
13 Reads

Therapeutic Effect of Steroids in Osmotic Demyelination of Infancy.

Authors:
Lalit R Bansal

Child Neurol Open 2018 15;5:2329048X18770576. Epub 2018 Apr 15.

Division of Neurology, Children's Mercy Hospital, Kansas City, MO, USA.

An 11-month-old male presented with acute gastroenteritis, seizures, and altered mental status. Laboratory workup revealed serum sodium of 177 mmol/L. Magnetic resonance imaging of the brain showed reduced diffusion in the supratentorial white matter, T2 hyperintensities in the left central pons and midbrain, subacute stroke in the right occipital lobe, and bilateral cerebellar hemorrhagic infarcts. Read More

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http://dx.doi.org/10.1177/2329048X18770576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903026PMC
April 2018
10 Reads

De Novo KCNQ2 Mutation in One Case of Epilepsy of Infancy With Migrating Focal Seizures That Evolved to Infantile Spasms.

Child Neurol Open 2018 11;5:2329048X18767738. Epub 2018 Apr 11.

Department of Pediatrics, Xiang Ya Hospital, Central South University, Changsha, Hunan Province, China.

Epilepsy of infancy with migrating focal seizures (EIMFS) is a rare type of early-onset epileptic encephalopathy that is characterized by refractory migratory multifocal seizures that migrate between hemispheres. Its etiology is not well known although it is postulated to occur due to channelopathy. The authors report the first case of EIMFS due to a de novo heterozygous mutation in exon 4(c. Read More

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http://dx.doi.org/10.1177/2329048X18767738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900813PMC
April 2018
4 Reads