94,330 results match your criteria Child Psychiatry & Human Development[Journal]


Effect of prenatal bisphenol A exposure on early childhood body mass index through epigenetic influence on the insulin-like growth factor 2 receptor (IGF2R) gene.

Environ Int 2020 Jul 6;143:105929. Epub 2020 Jul 6.

Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul 03080, Republic of Korea; Section of Environmental Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen 1014, Denmark. Electronic address:

Objectives: Epigenetic mechanisms have been suggested to play a role in the link between in utero exposure to bisphenol A (BPA) and pediatric obesity; however, there is little evidence regarding this mechanism in humans. We obtained data on obesity-associated CpG sites from a previous epigenome-wide association study, and then examined whether methylation at those CpG sites was influenced by prenatal BPA exposure. We then evaluated the relationship between CpG methylation status and body mass index (BMI) in a prospective children's cohort at ages 2, 4, 6, and 8 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envint.2020.105929DOI Listing

Defining the phenotype of FHF1 developmental and epileptic encephalopathy.

Epilepsia 2020 Jul 9. Epub 2020 Jul 9.

Rare and Complex Epilepsy Unit, Department of Neuroscience, Bambino Gesù Children's Hospital IRCCS, Member of European Reference Network EpiCARE, Rome, Italy.

Fibroblast growth-factor homologous factor (FHF1) gene variants have recently been associated with developmental and epileptic encephalopathy (DEE). FHF1 encodes a cytosolic protein that modulates neuronal sodium channel gating. We aim to refine the electroclinical phenotypic spectrum of patients with pathogenic FHF1 variants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/epi.16582DOI Listing

Predicting externalizing behavior in toddlerhood from early individual differences in empathy.

J Child Psychol Psychiatry 2020 Jul 9. Epub 2020 Jul 9.

School of Social Work and Social Welfare, The Hebrew University of Jerusalem, Jerusalem, Israel.

Background: From middle childhood onward, there is often a negative link between empathy and externalizing behavior problems. Patterns at younger ages are still unclear, with mixed findings of no association, negative associations, and positive associations. This study examines links between empathy and externalizing problems, beginning in infancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcpp.13247DOI Listing

Associations of perceived adverse lifetime experiences with brain structure in UK Biobank participants.

J Child Psychol Psychiatry 2020 Jul 9. Epub 2020 Jul 9.

Department of Psychiatry, University of Oxford, Oxford, UK.

Background: Adversity experiences (AEs) are major risk factors for psychiatric illness, and ample evidence suggests that adversity-related changes in brain structure enhance this vulnerability. To achieve greater understanding of the underlying biological pathways, increased convergence among findings is needed. Suggested future directions may benefit from the use of large population samples which may contribute to achieving this goal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcpp.13298DOI Listing

Internet, gaming, and smartphone usage patterns of children and adolescents in Korea: A c-CURE clinical cohort study.

J Behav Addict 2020 Jul 7. Epub 2020 Jul 7.

6Department of Psychiatry, Uijeongbu St. Mary's Hospital, Catholic University College of Medicine, Gyeonggi, South Korea.

Background And Aim: Whereas many studies on Internet gaming disorder (IGD) have used self-report questionnaires, only a few have adopted clinical interviews and samples. The current study aimed at using data from face-to-face diagnostic interviews, based on the criteria for IGD in the DSM-5, to determine the Internet, gaming, and smartphone usage patterns of children and adolescents.

Methods: A latent class analysis was conducted using data collected through diagnostic interviews for Internet, gaming, and smartphone addiction with 190 participants (M = 13. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1556/2006.2020.00022DOI Listing

Effects of Extended-Release Methylphenidate Treatment on Cognitive Task Performance in Children with Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder.

J Child Adolesc Psychopharmacol 2020 Jul 9. Epub 2020 Jul 9.

Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.

To examine the effectiveness of four doses of psychostimulant medication, combining extended-release methylphenidate (ER-MPH) in the morning with immediate-release MPH (IR-MPH) in the afternoon, on cognitive task performance. The sample comprised 24 children (19 boys and 5 girls) who met the (DSM-IV-TR) criteria for an autism spectrum disorder (ASD) on the and the , and had significant symptoms of attention-deficit/hyperactivity disorder (ADHD). This sample consisted of elementary school-age, community-based children (mean chronological age = 8. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/cap.2020.0004DOI Listing

Implementation Strategies for Depression and Anxiety Screening in a Pediatric Cystic Fibrosis Center: A Quality Improvement Project.

Pediatr Pulmonol 2020 Jul 9. Epub 2020 Jul 9.

Seattle Children's Hospital, Seattle, WA.

Background: Guidelines to integrate mental health screening (MHS) into cystic fibrosis (CF) care has increased adoption across US and European CF Centers, however there has been limited discussion on specific strategies for implementation.

Objective: Share key strategies that led to successful MHS implementation in one pediatric CF center and report implementation and screening outcomes.

Methods: Parent partners, mental health experts from the Department of Psychiatry, and the CF clinic team co-designed interventions to support 3 major stakeholders: (1) patients and families (2) clinic team, and (3) hospital system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ppul.24951DOI Listing

Anti-dopamine D2 receptor antibodies in chronic tic disorders.

Dev Med Child Neurol 2020 Jul 9. Epub 2020 Jul 9.

Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", Bari, Italy.

Aim: To investigate the association between circulating anti-dopamine D2 receptor (D2R) autoantibodies and the exacerbation of tics in children with chronic tic disorders (CTDs).

Method: One hundred and thirty-seven children with CTDs (108 males, 29 females; mean age [SD] 10y 0mo [2y 7mo], range 4-16y) were recruited over 18 months. Patients were assessed at baseline, at tic exacerbation, and at 2 months after exacerbation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dmcn.14613DOI Listing

COVID-19 infection and mental disorders: a call for action to enhance protection and break down barriers.

Psychiatr Hung 2020 ;35(3):245-246

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy, E-mail:

No abstract available. Read More

View Article

Download full-text PDF

Source
January 2020

Risperidone plasma concentrations are associated with side-effects and effectiveness in children and adolescents with autism spectrum disorder.

Br J Clin Pharmacol 2020 Jul 9. Epub 2020 Jul 9.

Department of Hospital Pharmacy, Erasmus MC, University Medical Center Rotterdam, The Netherlands.

Aim: Risperidone is the most commonly prescribed antipsychotic drug to children and adolescents worldwide, but is associated with serious side-effects, including weight gain. This study assessed the relationship of risperidone and 9-hydroxyrisperidone trough concentrations, maximum concentrations and 24-h area-under-the curves with BMI z-scores in children and adolescents with autism spectrum disorder (ASD) and behavioral problems. Secondary outcomes were metabolic, endocrine, extrapyramidal and cardiac side-effects and effectiveness. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bcp.14465DOI Listing

Family Contextual Factors are Differentially Associated with Depressive Symptoms among Boys and Girls with Perinatally Acquired HIV.

AIDS Behav 2020 Jul 8. Epub 2020 Jul 8.

Department of Psychiatry and Behavioral Health, Stony Brook University, Stony Brook, NY, USA.

Youth with perinatally acquired HIV (PHIV) are at risk for depressive symptoms, which are associated with a range of adverse outcomes. Although family contextual factors associated with depressive symptoms differ among boys and girls without PHIV, it is unclear whether this is also the case among youth with PHIV. Participants included 314 youth with PHIV (M = 12. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10461-020-02966-3DOI Listing

Repetitive Behavior in Children and Adolescents: Psychometric Properties of the German Version of the Repetitive Behavior Scale-Revised.

J Autism Dev Disord 2020 Jul 8. Epub 2020 Jul 8.

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Autism Research and Intervention Center of Excellence, University Hospital Frankfurt, Goethe-University, Goethe-Universität, Deutschordenstr. 50, 60528, Frankfurt, Germany.

Restricted repetitive behaviors (RRBs) are a core feature of autism spectrum disorders (ASD) and further occur in intellectual disability (ID), mental disorders (MD), and in typically developed people (TD). There is a need of a valid and reliable measure to record RRBs as transdiagnostic symptom, which captures RRBs heterogeneity and evaluates severity. The Repetitive Behavior Scale-Revised (RBS-R) is an established screening instrument for RRBs, but was predominantly limited to ASD samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10803-020-04588-zDOI Listing

Social Cognition in Autism and Schizophrenia Spectrum Disorders: The Same but Different?

J Autism Dev Disord 2020 Jul 8. Epub 2020 Jul 8.

Department of Child and Adolescent Psychiatry, Programa AMI-TEA, Servicio de Psiquiatría del Niño y del Adolescente, Hospital General Universitario Gregorio Marañón, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, School of Medicine, Instituto de Investigación Sanitaria Gregorio Marañón, IiSGM, Universidad Complutense, C/ Ibiza, 43, 28009, Madrid, Spain.

Social cognition impairment is a core shared phenotype in both schizophrenia spectrum disorders (SSD) and autism spectrum disorders (ASD). This study compares social cognition performance through four different instruments in a sample of 147 individuals with ASD or SSD and in healthy controls. We found that both clinical groups perform similarly to each other and worse than healthy controls in all social cognition tasks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10803-020-04408-4DOI Listing

Knowledge, attitude, and behavior of elementary teachers regarding attention deficit hyperactivity disorder.

J Educ Health Promot 2020 28;9:120. Epub 2020 May 28.

Department of Biostatistics and Epidemiology, Isfahan University of Medical Sciences, Isfahan, Iran.

Introduction: Attention deficit hyperactivity disorder (ADHD) is a common disorder in child psychiatry, which has a greater impact on the future life of the children affected in case of being untreated and undiagnosed. Given the undeniable role of teachers in improving this disorder and preventing its destructive consequences on children, the present research has examined the knowledge, attitude, and practice of elementary school teachers regarding ADHD.

Materials And Methods: This was a descriptive, cross-sectional study carried out in 2019. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jehp.jehp_696_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325758PMC

Infant EEG theta modulation predicts childhood intelligence.

Sci Rep 2020 Jul 8;10(1):11232. Epub 2020 Jul 8.

Centre for Brain and Cognitive Development, Birkbeck, University of London, Malet Street, London, WC1E 7HX, UK.

Intellectual functioning is a critical determinant of economic and personal productivity. Identifying early neural predictors of cognitive function in infancy will allow us to map the neurodevelopmental pathways that underpin individual differences in intellect. Here, in three different cohorts we investigate the association between a putative neurophysiological indicator of information encoding (change in frontal theta during a novel video) in infancy and later general cognitive outcome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-67687-yDOI Listing

Author Correction: Immediate early gene fingerprints of multi-component behaviour.

Sci Rep 2020 Jul 8;10(1):11483. Epub 2020 Jul 8.

Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Dresden, Germany.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-65177-9DOI Listing

Linking epigenetic dysregulation, mitochondrial impairment, and metabolic dysfunction in SBMA motor neurons.

JCI Insight 2020 Jul 9;5(13). Epub 2020 Jul 9.

Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA.

Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disorder caused by a polyglutamine expansion in the androgen receptor (AR). Using gene expression analysis and ChIP sequencing, we mapped transcriptional changes in genetically engineered patient stem cell-derived motor neurons. We found that transcriptional dysregulation in SBMA can occur through AR-mediated histone modification. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/jci.insight.136539DOI Listing

Role of optimism in adolescent mental health: a protocol for a systematic review.

BMJ Open 2020 Jul 7;10(7):e036177. Epub 2020 Jul 7.

Programa de Pós-Graduação em Teoria e Pesquisa do Comportamento, Universidade Federal do Pará, Belém, Para, Brazil.

Introduction: Adolescence is a critical period of human development, where adaptive or maladaptive experiences can happen. These experiences are associated with psychological, social, biological and health factors. Previous empirical evidence suggests that mental health is associated with individual assets and positive states, whose presence may become a factor of protection and resistance to mental disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2019-036177DOI Listing

Impact of matching error on linked mortality outcome in a data linkage of secondary mental health data with Hospital Episode Statistics (HES) and mortality records in South East London: a cross-sectional study.

BMJ Open 2020 Jul 7;10(7):e035884. Epub 2020 Jul 7.

South London and Maudsley NHS Foundation Trust, London, UK.

Objectives: Linkage of electronic health records (EHRs) to Hospital Episode Statistics (HES)-Office for National Statistics (ONS) mortality data has provided compelling evidence for lower life expectancy in people with severe mental illness. However, linkage error may underestimate these estimates. Using a clinical sample (n=265 300) of individuals accessing mental health services, we examined potential biases introduced through missed matching and examined the impact on the association between clinical disorders and mortality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2019-035884DOI Listing

Prevalence, Patterns, and Correlates of Pain in Medically Hospitalized Pediatric Patients With Somatic Symptom and Related Disorders.

Psychosomatics 2020 May 22. Epub 2020 May 22.

Department of Psychiatry, Boston Children's Hospital and Harvard Medical School, Boston, MA.

Background: Somatic symptom and related disorders (SSRDs) and pain are highly comorbid in the pediatric population. Little is known about the prevalence of pain and factors that may predispose and perpetuate pain in hospitalized youth with SSRD.

Objective: To describe the prevalence of pain and widespread pain symptoms in hospitalized youth with SSRD and describe differences between patients who endorsed limited (1-4 sites) versus widespread (5-8 sites) pain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.psym.2020.05.008DOI Listing

Co-occurring trajectories of anxiety and insistence on sameness behaviour in autism spectrum disorder.

Br J Psychiatry 2020 Jul 9:1-8. Epub 2020 Jul 9.

Centre for Addiction and Mental Health; and The Hospital for Sick Children; and Department of Psychiatry, University of Toronto, Toronto, Canada.

Background: Children with autism spectrum disorder (ASD) have increased susceptibility to anxiety disorders. Variation in a common ASD symptom, insistence on sameness behaviour, may predict future anxiety symptoms.

Aims: To describe the joint heterogeneous longitudinal trajectories of insistence on sameness and anxiety in children with ASD and to characterise subgroups at higher risk for anxiety. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1192/bjp.2020.127DOI Listing

Introducing a single point of access (SPA) to child and adolescent mental health services in England: a mixed-methods observational study.

BMC Health Serv Res 2020 Jul 8;20(1):623. Epub 2020 Jul 8.

Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, England.

Background: In many high-income countries, primary care practitioners are the main point of referral for specialist mental health services. In England, Child and Adolescent Mental Health Services (CAMHS) are increasingly adopting a Single Point of Access (SPA) to streamline referrals and introduce self and parent/carer-referrals. This involves a significant shift of responsibility from primary care towards CAMHS who adopt a more active role as gatekeeper for their service. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12913-020-05463-4DOI Listing

Editorial: Important First Look at Population-Based Trajectories of Youth With Autism.

J Am Acad Child Adolesc Psychiatry 2020 Jul 3. Epub 2020 Jul 3.

Columbia University; the New York State Psychiatric Institute; and the Center for Autism and the Developing Brain, New York Presbyterian Hospital. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaac.2020.06.011DOI Listing

Integrated Transcriptome and Network Analysis Reveals Spatiotemporal Dynamics of Calvarial Suturogenesis.

Cell Rep 2020 Jul;32(1):107871

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Cell, Developmental and Regenerative Biology and Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Craniofacial abnormalities often involve sutures, the growth centers of the skull. To characterize the organization and processes governing their development, we profile the murine frontal suture, a model for sutural growth and fusion, at the tissue- and single-cell level on embryonic days (E)16.5 and E18. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2020.107871DOI Listing

Bidirectional links between adolescent brain function and substance use moderated by cognitive control.

J Child Psychol Psychiatry 2020 Jul 8. Epub 2020 Jul 8.

Department of Psychology, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.

Background: No clear consensus exists as to whether neurodevelopmental abnormalities among substance users reflect predisposing neural risk factors, neurotoxic effects of substances, or both. Using a longitudinal design, we examined developmental patterns of the bidirectional links between neural mechanisms and substance use throughout adolescence.

Method: 167 adolescents (aged 13-14 years at Time 1, 53% male) were assessed annually four times. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcpp.13285DOI Listing

Community attitudes on genetic research of gender identity, sexual orientation, and mental health.

PLoS One 2020 8;15(7):e0235608. Epub 2020 Jul 8.

Department of Psychiatry, University of Iowa, Iowa City, Iowa, United States of America.

Sex is an important factor in mental health, and a non-binary view of how variation in sex and gender influence mental health represents a new research frontier that may yield new insights. The recent acceleration of research into sexual orientation, gender identity, and mental health has generally been conducted without sufficient understanding of the opinions of sexual and gender minorities (SGM) toward this research. We surveyed 768 individuals, with an enrichment of LGBTQ+ stakeholders, for their opinions regarding genetic research of SGM and mental health. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235608PLOS

Implementation of Home-Based Telemental Health in a Large Child Psychiatry Department During the COVID-19 Crisis.

J Child Adolesc Psychopharmacol 2020 Jul 8. Epub 2020 Jul 8.

Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.

Telemental health (TMH) is not well described for mental health service delivery during crises. Most child and adolescent psychiatry training programs have not integrated TMH into their curricula and are ill equipped to respond during crises to their patients' needs. In this study, we present the implementation of a home-based TMH (HB-TMH) service during the COVID-19 pandemic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/cap.2020.0062DOI Listing

Fathers of Children With Congenital Heart Disease: Sources of Stress and Opportunities for Intervention.

Pediatr Crit Care Med 2020 Jun 26. Epub 2020 Jun 26.

Division of Behavioral Health, Department of Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE.

Objectives: To examine sources of stress for fathers of children with congenital heart disease and opportunities for intervention to prevent or reduce paternal mental health problems.

Design: Qualitative study using online crowdsourcing, an innovative research methodology to create an online community to serve as a research sample.

Setting: Yammer, an online social networking site. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PCC.0000000000002388DOI Listing

Aripiprazole Elevated the Thyroid-Stimulating Hormone Level and is Associated With Hyperprolactinemia.

J Clin Psychopharmacol 2020 Jul/Aug;40(4):424-425

Kızıltepe State Hospital Child and Adolescent Psychiatry Mardin, Turkey Manisa Celal Bayar University, Faculty of Medicine, Department of Child and Adolescent Psychiatry, Manisa, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JCP.0000000000001240DOI Listing

Neuroendocrine Response to Apomorphine After Tetrahydrobiopterin Use in a Depressed Teenager With Mild Hyperphenylalaninemia: A Case Report.

J Clin Psychopharmacol 2020 Jul/Aug;40(4):414-416

Department of Child and Adolescent Psychiatry, Rouffach Hospital, Rouffach, France ICube-CNRS UMR 7357, Neurophysiology, FMTS, University of Strasbourg and CEMNIS-NonInvasive Neuromodulation Center, University Hospital of Strasbourg, Strasbourg, France Department of Psychiatry, Rouffach Hospital, Rouffach, France ICube-CNRS UMR 7357, Neurophysiology, FMTS, University of Strasbourg; and CEMNIS-NonInvasive Neuromodulation Center, University Hospital of Strasbourg, Strasbourg, France Department of Child and Adolescent Psychiatry, Rouffach Hospital, Rouffach, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JCP.0000000000001241DOI Listing

Commentary on Evans et al. (2020): the complex interplay between adolescent substance use, internalizing and externalizing symptoms.

Authors:
João Picoito

Addiction 2020 Jul 8. Epub 2020 Jul 8.

Department of Child and Adolescent Psychiatry, Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/add.15171DOI Listing

Pathways to gender affirmation in trans youth: A qualitative and participative study with youth and their parents.

Clin Child Psychol Psychiatry 2020 Jul 8:1359104520938427. Epub 2020 Jul 8.

Canada research Chair on transgender children and their families, UdM, Canada.

How trans youth realize about their gender identity and come out to their significant others is under-researched and very few studies include both youth and parental perspectives. This study was developed in Switzerland, a country where families with trans youth are just beginning to break invisibility. The research protocol draws on grounded theory methodology, is participative and developed in collaboration with a local trans NGO and a pan Canadian project. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1359104520938427DOI Listing

Phenotypic and Molecular Characterization of Risk Loci Associated With Asthma and Lung Function.

Allergy Asthma Immunol Res 2020 Sep;12(5):806-820

Department of Psychiatry, Yale University School of Medicine and VA CT Healthcare Center, West Haven, CT, United States.

Purpose: Respiratory diseases have a highly multifactorial etiology where different mechanisms contribute to the individual's susceptibility. We conducted a deep characterization of loci associated with asthma and lung function by previous genome-wide association studies (GWAS).

Methods: Sixteen variants were selected from previous GWAS of childhood/adult asthma and pulmonary function tests. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4168/aair.2020.12.5.806DOI Listing
September 2020

Actigraphy in sleep research with infants and young children: Current practices and future benefits of standardized reporting.

J Sleep Res 2020 Jul 8:e13134. Epub 2020 Jul 8.

Psychosomatics and Psychiatry, University Children's Hospital, Zurich, Switzerland.

Actigraphy is a cost-efficient method to estimate sleep-wake patterns over long periods in natural settings. However, the lack of methodological standards in actigraphy research complicates the generalization of outcomes. A rapidly growing methodological diversity is visible in the field, which increasingly necessitates the detailed reporting of methodology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jsr.13134DOI Listing

Tuning into the real effect of smartphone use on parenting: a multiverse analysis.

J Child Psychol Psychiatry 2020 Jul 7. Epub 2020 Jul 7.

Science Unit, Australian Broadcasting Corporation (ABC), Sydney, NSW, Australia.

Background: Concerns have been raised regarding the potential negative impacts of parents' smartphone use on the parent-child relationship. A scoping literature review indicated inconsistent effects, arguably attributable to different conceptualizations of parent phone use and conflation of phone use with technological interference.

Methods: Based on a sample of n = 3, 659 parents collected in partnership with a national public broadcaster, we conducted a multiverse analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcpp.13282DOI Listing

Cerebral Organoids: A Human Model for AAV Capsid Selection and Therapeutic Transgene Efficacy in the Brain.

Mol Ther Methods Clin Dev 2020 Sep 1;18:167-175. Epub 2020 Jun 1.

Department of Research & Development, uniQure Biopharma B.V., Amsterdam, the Netherlands.

The development of gene therapies for central nervous system disorders is challenging because it is difficult to translate preclinical data from current and models to the clinic. Therefore, we developed induced pluripotent stem cell (iPSC)-derived cerebral organoids as a model for recombinant adeno-associated virus (rAAV) capsid selection and for testing efficacy of AAV-based gene therapy in a human context. Cerebral organoids are physiological 3D structures that better recapitulate the human brain compared with 2D cell lines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.omtm.2020.05.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327852PMC
September 2020

Efficacy and Safety of Quetiapine for Pediatric Bipolar Depression: A Systematic Review of Randomized Clinical Trials.

Cureus 2020 Jun 2;12(6):e8407. Epub 2020 Jun 2.

Psychiatry, Griffin Memorial Hospital, Norman, USA.

Quetiapine is a second-generation antipsychotic (SGA) approved by the Food and Drug Administration (FDA) for the treatment of schizophrenia, mania, and aggression in children and adolescents. It is also commonly used as an off-label medication to treat children and adolescents with bipolar depression, although the FDA has not approved quetiapine for this purpose. We conducted a systematic review of randomized clinical trials (RCTs) using the MEDLINE database and included two studies that met our inclusion criteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.8407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331915PMC

Outcomes of inpatient psychological treatments for children and adolescents with eating disorders at time of discharge: a systematic review.

J Eat Disord 2020 3;8:32. Epub 2020 Jul 3.

Department of Psychiatry & Behavioural Neurosciences, McMaster University, Hamilton, ON L8N3Z5 Canada.

Background: Recommended first line treatment for children and adolescent eating disorders is outpatient therapy. However, a significant number of children and adolescents with eating disorders continue to require inpatient treatment during the course of their illness. The effect of psychological treatments in an inpatient setting on outcomes at the time of discharge remains unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40337-020-00307-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333407PMC

Mapping the Specific Pathways to Early-Onset Mental Health Disorders: The "Watch Me Grow for REAL" Study Protocol.

Front Psychiatry 2020 19;11:553. Epub 2020 Jun 19.

Faculty of Science, School of Psychology, University of Sydney, Sydney, NSW, Australia.

Background: From birth, the human propensity to selectively attend and respond to critical super-stimuli forms the basis of future socio-emotional development and health. In particular, the first super-stimuli to preferentially engage and elicit responses in the healthy newborn are the physical touch, voice and face/eyes of caregivers. From this grows selective attention and responsiveness to emotional expression, scaffolding the development of empathy, social cognition, and other higher human capacities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpsyt.2020.00553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319093PMC

Family Environment, Neurodevelopmental Risk, and the Environmental Influences on Child Health Outcomes (ECHO) Initiative: Looking Back and Moving Forward.

Front Psychiatry 2020 19;11:547. Epub 2020 Jun 19.

Division of Child and Adolescent Psychiatry, Columbia University, New York, NY, United States.

The family environment, with all its complexity and diverse components, plays a critical role in shaping neurodevelopmental outcomes in children. Herein we review several domains of the family environment (family socioeconomic status, family composition and home environment, parenting behaviors and interaction styles, parental mental health and functioning, and parental substance use) and discuss how these domains influence neurodevelopment, with particular emphasis on mental health outcomes. We also highlight a new initiative launched by the National Institutes of Health, the Environmental influences on Child Health Outcomes (ECHO) program. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpsyt.2020.00547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318113PMC

Machine Learning for Differential Diagnosis Between Clinical Conditions With Social Difficulty: Autism Spectrum Disorder, Early Psychosis, and Social Anxiety Disorder.

Front Psychiatry 2020 19;11:545. Epub 2020 Jun 19.

Autism Clinic for Translational Research, Child Neurodevelopment and Mental Health Team, Brain and Mind Centre, Children's Hospital Westmead l Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Autstralia.

Differential diagnosis in adult cohorts with social difficulty is confounded by comorbid mental health conditions, common etiologies, and shared phenotypes. Identifying shared and discriminating profiles can facilitate intervention and remediation strategies. The objective of the study was to identify salient features of a composite test battery of cognitive and mood measures using a machine learning paradigm in clinical cohorts with social interaction difficulties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpsyt.2020.00545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319094PMC

Children of Patients Undergoing Psychiatric Treatment: An Investigation of Statutory Support Services After Referrals to Child Protection Services.

Front Psychiatry 2020 19;11:527. Epub 2020 Jun 19.

Copenhagen Research Center for Mental Health-CORE, Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.

Aims: Preventive interventions for children of parents with mental illness are widely recommended. Mental health services entrust concern for patients' children by referrals to child protection services. We investigated service coverage for children following referrals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpsyt.2020.00527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319086PMC

Psychological and Physical Intimate Partner Violence and Maternal Depressive Symptoms during the Pre- and Post-Partum Period among Women Living with HIV in rural South Africa.

J Fam Violence 2020 Jan 17;35(1):73-83. Epub 2018 Dec 17.

Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine.

Purpose: Women in South Africa also have high rates of depression and intimate partner violence, and they often co-occur. Women living with HIV who experience IPV are particularly likely to experience elevated levels of depressive symptoms and such symptoms are more likely to persist. Although the association between IPV and depression has been examined extensively, the role of depression on IPV has not. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10896-018-0027-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339971PMC
January 2020

Objective Measures of Vest Therapy Adherence Among Pediatric Subjects With Cystic Fibrosis.

Respir Care 2020 Jul 7. Epub 2020 Jul 7.

Children's Minnesota Research Institute, Minneapolis, Minnesota.

Background: Airway clearance techniques (ACTs), including high-frequency chest wall oscillation (vest therapy), are important for maintaining lung function for patients with cystic fibrosis, but daily completion of ACTs is time-consuming and cumbersome. Patient adherence is a persistent challenge, and adherence data are largely patient reported, which may reduce accuracy. To provide definitive adherence data, this study utilized a Bluetooth-enabled vest therapy system to remotely collect objective adherence data from a cohort of pediatric subjects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4187/respcare.07421DOI Listing

Parent-based prevention after parental weight loss surgery: a pilot case-series trial.

Surg Obes Relat Dis 2020 May 28. Epub 2020 May 28.

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California.

Background: Overeating and obesity are elevated in children of parents who have undergone weight loss surgery. Parents who have undergone weight loss surgery often report their personal history of obesity interferes with their knowledge, skills, and self-efficacy in developing their children's healthy habits, thus reducing the likelihood of addressing obesogenic environmental factors.

Objectives: This study examines whether a 6-session parent-based prevention after bariatric surgery online intervention is feasible and acceptable for parents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.soard.2020.05.016DOI Listing

Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study.

BMC Neurosci 2020 Jul 7;21(1):30. Epub 2020 Jul 7.

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark.

Background: One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phenotypes are scarce, relative to studies of other cognitive traits and neurodevelopmental phenotypes. Moreover, most genetic studies examining such phenotypes do not incorporate parent-of-origin effects, which could account for some of the heritability of the investigated trait. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12868-020-00581-5DOI Listing

Secondary Traumatization Outcomes and Associated Factors Among the Health Care Workers Exposed to the COVID-19.

Int J Soc Psychiatry 2020 Jul 8:20764020940742. Epub 2020 Jul 8.

Department of Child and Adolescent Psychiatry, Istanbul Medeniyet University, Goztepe Education and Research Hospital, Istanbul, Turkey.

Background: Secondary traumatization exposure and mental health conditions of health care workers gained importance during the coronavirus disease 2019 (COVID-19) epidemic period.

Aims: In our study, we aim to research the secondary traumatization and associated factors among health care workers.

Method: This cross-sectional study was applied through an online questionnaire using the snowball sampling method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0020764020940742DOI Listing