2,233,462 results match your criteria Child & Family Behavior Therapy[Journal]


Health-Related Quality of Life in Biliary Atresia Patients with Native Liver or Transplantation.

Eur J Pediatr Surg 2020 Jul 6. Epub 2020 Jul 6.

Department of Pediatric Surgery, University Medical Center Groningen, Groningen, The Netherlands.

Introduction:  We aimed to assess health-related quality of life (HrQoL) in biliary atresia (BA) patients, based on original data and a literature review, and to determine factors associated with their HrQoL.

Materials And Methods:  We reviewed available studies describing HrQoL in BA patients. We assessed HrQoL in Dutch BA patients (6-16 years) using the validated Child Health Questionnaire. Read More

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http://dx.doi.org/10.1055/s-0040-1712932DOI Listing

Long-Term Health-Related Quality of Life in Survivors of Congenital Diaphragmatic Hernia.

Eur J Pediatr Surg 2020 Jul 6. Epub 2020 Jul 6.

Division of Pediatric Surgery, Departments of Surgery and Pediatrics & Child Health, University of Manitoba and Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.

The health-related quality of life (HRQoL) of survivors of congenital diaphragmatic hernia (CDH) is presently unknown. Literature prior to 2015 suggests that CDH survivors have worse HRQoL compared with the general population. However, due to changes in the diagnosis, management, and follow-up of CDH patients, this may no longer be true. Read More

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http://dx.doi.org/10.1055/s-0040-1713423DOI Listing

The renal dangers of an increased Cardio-Ankle Vascular Index.

Am J Hypertens 2020 Jul 7. Epub 2020 Jul 7.

Dipartimento PROMISE (Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties), Unit of Nephrology and Hypertension, European Society of Hypertension Excellence Centre, Università di Palermo, Italy.

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http://dx.doi.org/10.1093/ajh/hpaa110DOI Listing

Insomnia symptoms increase during pregnancy, but no increase in sleepiness - Associations with symptoms of depression and anxiety.

Sleep Med 2020 Apr 9;72:150-156. Epub 2020 Apr 9.

Department of Obstetrics and Gynecology, Turku University Hospital and University of Turku, Turku, Finland; Sleep Research Unit, Department of Physiology, University of Turku, Turku, Finland.

Objective: To evaluate alteration in insomnia and sleepiness symptoms during pregnancy and assess early pregnancy risk factors for these symptoms, especially depressive and anxiety symptoms.

Methods: A cohort of 1858 women was enrolled from the FinnBrain Birth Cohort Study. Insomnia and sleepiness symptoms were measured in early, mid- and late pregnancy with the Basic Nordic Sleep Questionnaire. Read More

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http://dx.doi.org/10.1016/j.sleep.2020.03.031DOI Listing

The scope of family-centred care practices, and the facilitators and barriers to implementation of family-centred care for hospitalised children and their families in developing countries: An integrative review.

J Pediatr Nurs 2020 Jul 3;55:10-28. Epub 2020 Jul 3.

(a)Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong SAR, China.

Problem: Limited knowledge exists regarding the scope practices and implementation from developing countries. This integrative review aims to report research on the scope of FCC practices, facilitators and barriers to the FCC implementation for hospitalised children and their families in developing countries.

Eligibility Criteria: Qualitative, quantitative, mixed-method studies, reports, systematic reviews and integrative reviews reporting implementation, barriers and facilitators of FCC, published in English between 2008 and 2018, from developing countries were evaluated. Read More

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http://dx.doi.org/10.1016/j.pedn.2020.05.018DOI Listing

The evolution of the human brain and disease susceptibility.

Curr Opin Genet Dev 2020 Jul 3;65:91-97. Epub 2020 Jul 3.

Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA; Yale Child Study Center, New Haven, CT 06510, USA; Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA; Departments of Psychiatry and Comparative Medicine, Kavli Institute for Neuroscience, Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address:

Evolutionary perspective is critical for understanding human biology, human medicine, and the traits that make human beings unique. One of the crucial characteristics that sets humans apart from other extant species is our cognitive ability, which allows for complex processes including symbolic thought, theory of mind, and syntactical-grammatical language, and is thought to arise from the expansion and specialization of the human nervous system. It has been hypothesized that the same evolutionary changes that allowed us to develop these valuable skills made humans susceptible to neurodevelopmental and neurodegenerative disease. Read More

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http://dx.doi.org/10.1016/j.gde.2020.05.004DOI Listing

Childhood maltreatment, serotonin transporter gene, and risk for callous and unemotional traits: A prospective investigation.

Psychiatry Res 2020 Jul 2;291:113271. Epub 2020 Jul 2.

Department of Genetics and Human Genetics Institute, Rutgers, The State University of New Jersey, 145 Bevier Road, Piscataway, NJ, 08854-8082, USA.

Previous studies have reported associations between the serotonin transporter 5-HTTLPR genotype and antisocial and aggressive traits and between child maltreatment and antisocial traits. However, few studies have examined whether 5-HTTLPR moderates the influence of childhood maltreatment on callous and unemotional traits, a hallmark of psychopathy. Using a prospective cohort design, children with documented cases of maltreatment and matched controls were followed up and interviewed in adulthood. Read More

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http://dx.doi.org/10.1016/j.psychres.2020.113271DOI Listing

A randomised double-blind trial of cognitive training for the prevention of psychopathology in at-risk youth.

Behav Res Ther 2020 Jun 23;132:103672. Epub 2020 Jun 23.

The Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Sydney, Australia.

Background: The aim of this study was to evaluate the effectiveness of online cognitive training as a means of reducing psychopathology in at-risk youth.

Methods: In a double-blind randomised controlled trial, 228 youths (mean age = 18.6, 74. Read More

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http://dx.doi.org/10.1016/j.brat.2020.103672DOI Listing

A latent class analysis to identify how patterns of Intimate Partner Violence influence Early Childhood Development outcomes in Honduras.

Authors:
Alejandra Leyton

Child Abuse Negl 2020 Jul 3;107:104609. Epub 2020 Jul 3.

Department of Global Community Health and Behavioral Sciences, Tulane University, School of Public Health and Tropical Medicine, 1440 Canal Street, Ste 2200-11, New Orleans, LA, 70112, United States. Electronic address:

Background: Intimate Partner Violence (IPV) against women is a complex phenomenon with long-term consequences for victims and their families.

Objective: The goals of this study are two-fold: to identify common patterns of co-occurring and/or successive experiences with IPV; and to study the association between these IPV patterns and outcomes of Early Childhood Development (ECD) among the victim's children.

Data And Participants: Data was obtained from the 2011-12 Honduras Demographic Health Survey (DHS). Read More

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http://dx.doi.org/10.1016/j.chiabu.2020.104609DOI Listing

Self-referent encoding facilitates memory binding in young children: New insights into the self-reference effect in memory development.

J Exp Child Psychol 2020 Jul 3;198:104919. Epub 2020 Jul 3.

School of Applied Psychology, Griffith University, Gold Coast, Queensland 4222, Australia.

Episodic memory allows humans to retrieve and distinguish specific memories. The formation of item-context bindings, whereby the to-be-recalled items are tied to aspects of the encoding context, is important to the effective operation of episodic memory. The self-reference effect refers to the memory advantage for items encoded in relation to the self versus another. Read More

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http://dx.doi.org/10.1016/j.jecp.2020.104919DOI Listing

The development of grit and growth mindset during adolescence.

J Exp Child Psychol 2020 Jul 3;198:104889. Epub 2020 Jul 3.

Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Individual differences in grit and growth mindset predict effort and achievement in the face of challenges, but little is known about how the two traits influence each other during adolescence. In the current investigation, we analyzed data on grit and growth mindset collected from 1667 adolescents and their teachers on four occasions over 2 academic years. In autoregressive cross-lagged models, grit predicted rank-order increases in growth mindset and growth mindset predicted rank-order increases in grit. Read More

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http://dx.doi.org/10.1016/j.jecp.2020.104889DOI Listing

Paying it back and forward: The impact of experiencing and observing others' sharing and stinginess on preschoolers' own sharing behavior and expectations.

J Exp Child Psychol 2020 Jul 3;198:104886. Epub 2020 Jul 3.

Department of Psychology, Ludwig-Maximilians-Universität München, 80802 Munich, Germany.

Recent research suggests that children's sharing behavior is affected by experiencing or observing others' sharing. These effects have been studied within research on the development of reciprocity and the effects of social modeling. In the current study, direct and indirect types of reciprocity and social modeling were assessed in 3- to 6-year-old children in three experiments (overall N = 382). Read More

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http://dx.doi.org/10.1016/j.jecp.2020.104886DOI Listing

Endometriosis and inflammatory bowel disease: A systematic review of the literature.

Eur J Obstet Gynecol Reprod Biol 2020 Jun 26;252:246-251. Epub 2020 Jun 26.

Department of Woman, Newborn and Child, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Via Commenda 12, 20122, Milan, Italy; Department of Clinical Sciences and Community Health, Università degli studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Commenda 12, 20122, Milan, Italy.

The potential link between endometriosis and Inflammatory Bowel Disease (IBD) has been investigated over the last twenty years. Endometriosis shares with IBD features and symptoms so to become a significant diagnostic challenge, resulting in a delayed or indeterminate diagnosis. We conducted a systematic review to summarize the available data in literature on the co-diagnosis of IBD and endometriosis. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.06.051DOI Listing

Efficacy of hyoscine butyl-bromide in shortening the active phase of labor: Systematic review and meta-analysis of randomized trials.

Eur J Obstet Gynecol Reprod Biol 2020 Jun 23;252:218-224. Epub 2020 Jun 23.

Department of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.

Introduction: Prolonged labor increases the risk of maternal and fetal complications. The active management of labor has been proven effective in lowering neonatal and maternal morbidity by shortening the duration of labor. Several pharmaceutical and non-pharmaceutical approaches are currently being used in the active management of labor. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.06.042DOI Listing

Intergenerational transmission of childhood trauma? Testing cellular aging in mothers exposed to sexual abuse and their children.

Psychoneuroendocrinology 2020 Jun 27;120:104781. Epub 2020 Jun 27.

Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA. Electronic address:

Background: Exposure to maltreatment in childhood can lead to increased risk for poor health outcomes in adulthood. Child maltreatment and later poor health may be linked by premature biological aging. We tested whether childhood sexual abuse (CSA) was associated with telomere length (TL) in adult females. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2020.104781DOI Listing

"I Could Never Prepare for Something Like the Death of My Own Child": Parental Perspectives on Preparedness at End of Life for Children with Complex Chronic Conditions.

J Pain Symptom Manage 2020 Jul 3. Epub 2020 Jul 3.

Assistant Professor, Division of Critical Care, Department of Pediatrics, Harvard Medical School, 300 Longwood Avenue, Main Building, 11 South Boston, Massachusetts 02115, United States.

Context: Children with complex chronic conditions (CCCs) have high morbidity and mortality. While these children often receive palliative care services, little is known about parental preparedness for their child's end of life (EOL).

Objectives: This study aimed to elucidate aspects important to preparedness at EOL among bereaved parents of children with CCCs. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2020.06.035DOI Listing

Human umbilical cord mesenchymal stem cell attenuates renal fibrosis via TGF-β/Smad signaling pathways in vivo and in vitro.

Eur J Pharmacol 2020 Jul 3:173343. Epub 2020 Jul 3.

Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China; Chongqing Key Laboratory of Children Urogenital Department and Tissue Engineering, Chongqing, 400014, China; Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, 400014, China; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, 400014, China; National Clinical Research Center for Child Health and Disorders, Chongqing, 400014, China; Chongqing Key Laboratory of Pediatrics, Chongqing, 400014, China. Electronic address:

Renal fibrosis is a progressive pathological process that eventually leads to end-stage renal failure with limited therapeutic options. The aim of this study was to investigate the nephron-protective effect of human umbilical cord mesenchymal stem cells (ucMSCs) on renal fibrosis. UcMSCs were intravenously injected into renal fibrosis mice induced by aristolochic acid (AA) and co-cultured with HK-2 cells induced by TGF-β1, respectively. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173343DOI Listing

Parent Technology Use, Parent-Child Interaction, Child Screen Time, and Child Psychosocial Problems among Disadvantaged Families.

J Pediatr 2020 Jul 3. Epub 2020 Jul 3.

Department of Paediatrics & Adolescent Medicine, The University of Hong Kong, Hong Kong. Electronic address:

Objective: To disentangle the pathways between parent technology use, parent-child interactions, child screen time, and child psychosocial difficulties among disadvantaged families in Hong Kong.

Study Design: Parents of 1,254 3-years-olds from the KeySteps@JC project reported on the number of hours their children used electronic devices every day and children's psychosocial behaviors using the Strengths and Difficulties Questionnaire. These parents also reported on their own digital device usage patterns, frequency of parent-child interactions and provided sociodemographic data. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.07.006DOI Listing

Adolescent Female with Severe Thigh Pain after the Splits.

J Pediatr 2020 Jul 3. Epub 2020 Jul 3.

Italy Institute for Maternal and Child Health "IRCCS Burlo Garofolo" Trieste, Italy.

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http://dx.doi.org/10.1016/j.jpeds.2020.06.087DOI Listing

Bleeding associated with low-dose aspirin: Comparison of data from the COMPASS randomized controlled trial and routine clinical practice.

Int J Cardiol 2020 Jul 3. Epub 2020 Jul 3.

Department of Public Health and Maternal and Child Health, Faculty of Medicine, Complutense University of Madrid, Spain.

Randomized controlled trials (RCTs) have strong internal validity but often have limited external validity. Observational studies have good generalizability and an increasing role in key healthcare decision making. We compared incidence rates of intracranial and major gastrointestinal bleeds in the low-dose aspirin arm (N = 9126) of the COMPASS double-blind RCT (conducted at 602 centres in 33 countries) with those from an observational cohort of preventative low-dose aspirin users (N = 54,140) in a primary care database representative of the UK general population - The IQVIA Medical Research Data UK (IMRD-UK). Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.06.048DOI Listing

Vaginal Yolk Sac Tumor: A Case Series and Review of the Literature.

J Pediatr Adolesc Gynecol 2020 Jul 3. Epub 2020 Jul 3.

Division of Gynecologic Specialties, Department of Gynecology and Obstetrics, Emory University School of Medicine; Divisions of Pediatric Surgery and Pediatrics, Children's Healthcare of Atlanta.

Objective: Report diagnosis, treatment, and outcomes of vaginal yolk sac tumor (YST) cases at a single institution and review literature on vaginal YST to outline advancements in diagnosis, treatment, and survival.

Design: Retrospective chart review of girls less than 21 years old with pathologic diagnosis of vaginal YST treated at a large children's hospital and summary of a 100-year review of the literature of vaginal yolk sac tumor.

Setting: Children's Healthcare of Atlanta, a tertiary center in Atlanta, Georgia PARTICIPANTS: Female patients < 21 years of age diagnosed with vaginal YST. Read More

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http://dx.doi.org/10.1016/j.jpag.2020.06.020DOI Listing

Links between Child and Adolescent Psychiatric Disorders and Cardiovascular Risk.

Can J Cardiol 2020 Jul 3. Epub 2020 Jul 3.

Department of Psychiatry, Hospital for Sick Children Department of Psychiatry, Faculty of Medicine, University of Toronto.

This narrative review, emphasizing children and adolescents, addresses the link between five psychiatric disorders and cardiovascular risk: attention deficit hyperactivity disorder (ADHD), autism spectrum disorders, anxiety disorders, depression, and bipolar disorders. The evidence regarding cardiovascular risk factors, non-invasive measures of early atherosclerosis, and cardiovascular disease prevalence and/or mortality is summarized. Whereas multiple studies have examined stimulant treatment of ADHD in relation to cardiovascular death, and autonomic-vagal function in autism spectrum disorders, little is known regarding atherosclerotic cardiovascular disease in these conditions. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.06.023DOI Listing

Establishing core outcome domains in pediatric kidney disease: report of the Standardized Outcomes in Nephrology - Children and Adolescents (SONG-KIDS) consensus workshops.

Kidney Int 2020 Jul 3. Epub 2020 Jul 3.

Sydney School of Public Health, The University of Sydney, Sydney, Australia; Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia.

Trials in children with chronic kidney disease (CKD) do not consistently report outcomes that are critically important to patients and caregivers. This can diminish the relevance and reliability of evidence for decision-making, limiting the implementation of results into practice and policy. As part of the Standardized Outcomes in Nephrology - Children and Adolescents (SONG-Kids) initiative, we convened two consensus workshops in San Diego, United States (7 patients, 24 caregivers, 43 health professionals; and Melbourne, Australia (7 patients, 23 caregivers, 49 health professionals). Read More

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http://dx.doi.org/10.1016/j.kint.2020.05.054DOI Listing

Action against racism: the path to better child health outcomes.

Lancet Child Adolesc Health 2020 Jul 3. Epub 2020 Jul 3.

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http://dx.doi.org/10.1016/S2352-4642(20)30212-1DOI Listing

Impact of low-level viraemia on virological failure among Asian children with perinatally acquired HIV on first-line combination antiretroviral treatment: a multicentre, retrospective cohort study.

J Int AIDS Soc 2020 Jul;23(7):e25550

Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand.

Introduction: The clinical relevance of low-level viraemia (LLV) and virological outcomes among children living with HIV (CLHIV) remains controversial. This study aimed to determine the impact of LLV on virological failure (VF) among Asian CLHIV on first-line combination antiretroviral therapy (cART).

Methods: CLHIV aged <18 years, who were on first-line cART for ≥12 months, and had virological suppression (two consecutive plasma viral load [pVL] <50 copies/mL) were included. Read More

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http://dx.doi.org/10.1002/jia2.25550DOI Listing

Long-term effects on growth of an energy-enhanced parenteral nutrition in preterm newborn: A quasi-experimental study.

PLoS One 2020 6;15(7):e0235540. Epub 2020 Jul 6.

Department of Maternal and Child Health Policlinico Umberto I, University La Sapienza, Rome, Italy.

Aim: To assess the best energy intake in Parenteral Nutrition (PN) for preterm newborns, considering both possible benefits for growth and risk of complications.

Methods: Quasi-experimental study comparing two cohorts of newborns, receiving Energy-Enhanced vs. Standard PN (Cohort A, from 1st January 2015 to 31 January 2016 and Cohort B from 1st February 2016 to 31 March 2017; respectively) after implementation of a change in the PN protocol. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235540PLOS

Prevalence and associated factors of delayed first antenatal care booking among reproductive age women in Ethiopia; a multilevel analysis of EDHS 2016 data.

PLoS One 2020 6;15(7):e0235538. Epub 2020 Jul 6.

Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Early or timely initiation of antenatal care and regular visits based on the schedule have a tremendous effect on both maternal and fetal health. Despite the paramount benefits of early initiation of ANC within the first 12 weeks of pregnancy, women still do not have adequate and equal access to high-quality early antenatal care.

Objective: To determine the prevalence and factors associated with delayed first ANC booking in Ethiopia. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235538PLOS

The proportion of non-depressed subjects in a study sample strongly affects the results of psychometric analyses of depression symptoms.

PLoS One 2020 6;15(7):e0235272. Epub 2020 Jul 6.

Department of Child and Adolescent Psychiatry and Psychotherapy (KJPP), University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.

Background: Recent studies have uncovered a peculiar finding: that the strength and dimensionality of depression symptoms' inter-relationships vary systematically across study samples with different average levels of depression severity. Our aim was to examine whether this phenomenon is driven by the proportion of non-affected subjects in the sample.

Methods: Cross-sectional data from the "Cohort Study on Substance Use Risk Factors" was analyzed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235272PLOS

Process Evaluation of an eHealth Intervention (Food4toddlers) to Improve Toddlers' Diet: Randomized Controlled Trial.

JMIR Hum Factors 2020 Jul 6;7(3):e18171. Epub 2020 Jul 6.

Department of Nutrition and Public Health, Faculty of Health and Sports Sciences, University of Agder, Kristiansand, Norway.

Background: Parents seek trustworthy information online to promote healthy eating for their toddlers. Such information must be perceived as relevant and easy to implement and use.

Objective: The objectives of this study were to conduct a process evaluation of the electronic health (eHealth) intervention (Food4toddlers) targeting food environment, parental feeding practices, and toddlers' diet and to examine possible differences in these areas according to education and family composition. Read More

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http://dx.doi.org/10.2196/18171DOI Listing

Differentiation of Human Induced Pluripotent Stem Cells Into Male Germ Cells.

Curr Stem Cell Res Ther 2020 Jul 5. Epub 2020 Jul 5.

Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz. Iran.

Infertility is defined as not being able to become pregnant or to conceive a child after one year or longer of regular unprotected intercourse. Male infertility refers to a male's inability to cause pregnancy that can result from deficiencies in semen quality, sperm concentration, or abnormal sperm function. Till now, there are few effective methods for the treatment of a couple with male infertility. Read More

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http://dx.doi.org/10.2174/1574888X15666200705214223DOI Listing

Association Between Oral Corticosteroid Bursts and Severe Adverse Events: A Nationwide Population-Based Cohort Study.

Ann Intern Med 2020 Jul 7. Epub 2020 Jul 7.

Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan (Y.H., S.T., H.T.).

Background: Long-term use of oral corticosteroids has known adverse effects, but the risk from brief oral steroid bursts (≤14 days) is largely unknown.

Objective: To examine the associations between steroid bursts and severe adverse events, specifically gastrointestinal (GI) bleeding, sepsis, and heart failure.

Design: Self-controlled case series. Read More

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http://dx.doi.org/10.7326/M20-0432DOI Listing

Prenatal Exposures to Perfluoroalkyl Acids and Associations with Markers of Adiposity and Plasma Lipids in Infancy: An Odense Child Cohort Study.

Environ Health Perspect 2020 Jul 6;128(7):77001. Epub 2020 Jul 6.

Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark.

Background: Perfluoroalkyl acids (PFAA) are repellants that cross the placental barrier, enabling interference with fetal programming. Maternal PFAA concentrations have been associated with offspring obesity and dyslipidemia in childhood and adulthood, but this association has not been studied in infancy.

Objectives: We investigated associations between maternal PFAA concentrations and repeated markers of adiposity and lipid metabolism in infancy. Read More

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http://dx.doi.org/10.1289/EHP5184DOI Listing

COVID-19 and the personal protection debate: An exposition on transmission.

Authors:

J Paediatr Child Health 2020 Jul 6. Epub 2020 Jul 6.

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http://dx.doi.org/10.1111/jpc.15054DOI Listing

NCAPH is upregulated in endometrial cancer and associated with poor clinicopathologic characteristics.

Ann Hum Genet 2020 Jul 6. Epub 2020 Jul 6.

Department of Gynecology and Obstetrics, Jining Maternal and Child Health Hospital, Jining, Shandong, China.

Background: Recently, NCAPH (non-SMC condensin I complex subunit H), a regulatory subunit of the condensin complex, has captured our attention in various cancer studies. However, the function of NCAPH in endometrial cancer (EC) remains unclear. Our study aims to investigate the role of NCAPH in EC. Read More

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http://dx.doi.org/10.1111/ahg.12398DOI Listing

"Safety in Dementia": Development of an Online Caregiver Tool for Firearm, Driving, and Home Safety.

J Am Geriatr Soc 2020 Jul 6. Epub 2020 Jul 6.

Department of Emergency Medicine, University of Colorado, School of Medicine, Aurora, Colorado, USA.

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http://dx.doi.org/10.1111/jgs.16693DOI Listing

Comparison of As-Needed and Scheduled Posthospitalization Follow-up for Children Hospitalized for Bronchiolitis: The Bronchiolitis Follow-up Intervention Trial (BeneFIT) Randomized Clinical Trial.

JAMA Pediatr 2020 Jul 6:e201937. Epub 2020 Jul 6.

Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California.

Importance: Posthospitalization follow-up visits are prescribed frequently for children with bronchiolitis. The rationale for this practice is unclear, but prior work has indicated that families value these visits for the reassurance provided. The overall risks and benefits of scheduled visits have not been evaluated. Read More

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http://dx.doi.org/10.1001/jamapediatrics.2020.1937DOI Listing

Evaluation of Color Difference in Placenta with Twin Anemia Polycythemia Sequence.

J Vis Exp 2020 Jun 17(160). Epub 2020 Jun 17.

Division of Neonatology, Department of Pediatrics, Leiden University Medical Center;

Twin anemia polycythemia sequence (TAPS) occurs in 5% of monochorionic twins and is characterized by large inter-twin hemoglobin differences. The postnatal diagnostic criteria for TAPS are based on hematologic parameters and placental characteristics. Placental examination after birth shows that color of the maternal side between placental territories of the anemic and polycythemic twins is remarkably different. Read More

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http://dx.doi.org/10.3791/61312DOI Listing

A Precision Medicine Tool for Patients With Multiple Sclerosis (the Open MS BioScreen): Human-Centered Design and Development.

J Med Internet Res 2020 Jul 6;22(7):e15605. Epub 2020 Jul 6.

Department of Neurology, UCSF Weill Institute for Neurosciences, San Francisco, CA, United States.

Background: Patients with multiple sclerosis (MS) face several challenges in accessing clinical tools to help them monitor, understand, and make meaningful decisions about their disease course. The University of California San Francisco MS BioScreen is a web-based precision medicine tool initially designed to be clinician facing. We aimed to design a second, openly available tool, Open MS BioScreen, that would be accessible, understandable, and actionable by people with MS. Read More

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http://dx.doi.org/10.2196/15605DOI Listing

Diabetes-Related Topics in an Online Forum for Caregivers of Individuals Living With Alzheimer Disease and Related Dementias: Qualitative Inquiry.

J Med Internet Res 2020 Jul 6;22(7):e17851. Epub 2020 Jul 6.

Center on Smart and Connected Health Technologies, School of Nursing, The University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.

Background: Diabetes and Alzheimer disease and related dementias (ADRD) are the seventh and sixth leading causes of death in the United States, respectively, and they coexist in many older adults. Caring for a loved one with both ADRD and diabetes is challenging and burdensome.

Objective: This study aims to explore diabetes-related topics in the Alzheimer's Association ALZConnected caregiver forum by family caregivers of persons living with ADRD. Read More

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http://dx.doi.org/10.2196/17851DOI Listing

Modelled plasma concentrations of pemafibrate with co-administered typical cytochrome P450 inhibitors clopidogrel, fluconazole, or clarithromycin predicted by physiologically based pharmacokinetic modelling in virtual populations.

Xenobiotica 2020 Jul 6:1-23. Epub 2020 Jul 6.

Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan.

Oral antidyslipidaemic drug pemafibrate is cleared from human plasma via hepatic uptake by organic anion transporting polypeptide (OATP) 1B1 and oxidation by cytochromes P450 (P450) 2C8, 2C9, and 3A4. The pharmacokinetic profiles of pemafibrate with virtual administrations of P450 inhibitors and/or disease interactions were generated using a physiologically based pharmacokinetic (PBPK) model previously established for co-administration of pemafibrate with OATP1B1 inhibitors.This PBPK model was validated in the current study using reported maximum pemafibrate plasma concentrations and areas under the curve from interaction studies in healthy subjects co-administered with clopidogrel (P450 2C8 inhibitor), fluconazole (P450 2C9/3A4 inhibitor), or clarithromycin (P450 3A4 inhibitor). Read More

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http://dx.doi.org/10.1080/00498254.2020.1793030DOI Listing

(Epi)genetic profiling of extraembryonic and postnatal tissues from female monozygotic twins discordant for Beckwith-Wiedemann syndrome.

Mol Genet Genomic Med 2020 Jul 6:e1386. Epub 2020 Jul 6.

Medical Genetics, Department of Pathophysiology & Transplantation, Università degli Studi di Milano, Milano, Italy.

Background: Beckwith-Wiedemann syndrome (BWS) is an overgrowth disorder caused by defects at the 11p15.5 imprinted region. Many cases of female monozygotic (MZ) twins discordant for BWS have been reported, but no definitive conclusions have been drawn regarding the link between epigenetic defects, twinning process, and gender. Read More

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http://dx.doi.org/10.1002/mgg3.1386DOI Listing

An Indian child with Coats plus syndrome due to mutations in STN1.

Am J Med Genet A 2020 Jul 6. Epub 2020 Jul 6.

Genomics and Molecular Medicine, CSIR-Institute of Genomics and Integrative Biology, Delhi, India.

The role of the CTC1-STN1-TEN1 (CST) complex in Coats plus syndrome (CP), as well as other telomeropathy-phenotypes and disorders of genome instability is well documented. We report an Indian child with a clinical diagnosis of CP who presented to us with retinal exudates, extensive cerebral calcification, developmental delay and severe anemia consequent upon chronic gastrointestinal (GI) bleeding. Whole exome sequencing revealed compound heterozygous variants in STN1 as the probable genetic cause leading to CP in the present case. Read More

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http://dx.doi.org/10.1002/ajmg.a.61737DOI Listing

Living resiliently: The voices of a group of child protection social workers in South Africa.

Health Soc Care Community 2020 Jul 6. Epub 2020 Jul 6.

School of Psychosocial Health, Optentia Research Focus Area, North-West University, Vanderbijlpark, South Africa.

Child protection social workers (CPSWs) do critical work protecting vulnerable children. Given the demanding nature of this work, CPSWs are reportedly at great risk for negative outcomes, such as burnout and depression. Another outcome is often unsatisfactory service delivery by CPSWs, leaving vulnerable children exposed to continued maltreatment. Read More

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http://dx.doi.org/10.1111/hsc.13076DOI Listing

Anxiety disorders in children with high intellectual potential.

BJPsych Open 2020 Jul 6;6(4):e70. Epub 2020 Jul 6.

Pôle Hospitalo-Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Centre National d'Aide aux enfants et adolescents à Haut Potentiel, Centre Hospitalier Guillaume Régnier, Université de Rennes 1; and Laboratoire Psychologie de la Perception, UMR 8242, Centre National de la Recherche Scientifique, France.

Background: Several studies have reported anxiety disorders in children with high intellectual potential (HIP). However, there are discrepant results possibly as a result of methodological biases (different/absent definitions of HIP, small sample sizes, non-validated/adapted/specific tools for assessing anxiety and a single observational source).

Aims: To examine more thoroughly the relationships between HIP and anxiety in large samples of children using clear definitions of HIP, different observational sources and specific assessments of anxiety. Read More

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http://dx.doi.org/10.1192/bjo.2019.104DOI Listing

Effect of Social Exclusion on Social Maladjustment Among Chinese Adolescents: A Moderated Mediation Model of Group Identification and Parent-Child Cohesion.

Authors:
Ye Zhang Kai Wang

J Interpers Violence 2020 Jul 4:886260520934444. Epub 2020 Jul 4.

Shenyang Normal University, China.

Social exclusion is a covert and widespread social behavior. Different from previous studies on the role of internal and social functions in the relationship between social exclusion and maladjustment, the study aims to explore the influence of individual interaction on the individual-group relationship as well as the impact of relationship changes on adolescent social maladjustment. Based on an integration of social information processing theory and social identification theory, we analyzed the association between social exclusion and adolescents' social maladjustment, especially the mediating role of group identification and the moderating role of parent-child cohesion. Read More

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http://dx.doi.org/10.1177/0886260520934444DOI Listing

Children's Disclosures of Physical Abuse in a Population-Based Sample.

J Interpers Violence 2020 Jul 4:886260520934443. Epub 2020 Jul 4.

University of Eastern Finland, Joensuu, Finland.

Few studies have explored the disclosure of child physical abuse although child sexual abuse disclosure has been widely studied and debated for years. The present study explores the characteristics of child physical abuse disclosures and compares them to previously published findings on child sexual abuse disclosure from the same data. The data consist of a representative sample of 11,364 sixth and ninth graders. Read More

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http://dx.doi.org/10.1177/0886260520934443DOI Listing

Effect of prenatal nutritional intervention on foetal growth restriction: a real-world study in Shenzhen, China.

J Matern Fetal Neonatal Med 2020 Jul 6:1-10. Epub 2020 Jul 6.

Guangzhou Key Laboratory of Environmental Pollution and Health Assessment, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China.

Fetal growth restriction (FGR) is the primary cause of infant morbidity and mortality. Although nutritional intervention is generally used to cure FGR, its effects on early- and late-onset FGR have not been reported. This study aimed to resolve this issue in a real-world setting. Read More

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http://dx.doi.org/10.1080/14767058.2020.1786512DOI Listing

Marijuana Use for Women: To Prescribe or Not to Prescribe.

Subst Use Misuse 2020 Jul 5:1-2. Epub 2020 Jul 5.

Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

The marijuana policy varies greatly worldwide. Marijuana use is illegal in most countries. Nevertheless, the medical potentials of marijuana have been increasingly uncovered, and its use by women is increasing. Read More

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http://dx.doi.org/10.1080/10826084.2020.1782938DOI Listing

Feasibility of a psychoeducational group intervention to improve parental reflective functioning and bonding in pregnancy: a randomised trial.

J Reprod Infant Psychol 2020 Jul 4:1-17. Epub 2020 Jul 4.

Department of Psychology, Durham University , Durham, UK.

Objective: To develop and evaluate Baby CHAT, a single-session psychoeducational intervention for expectant parents. Baby CHAT aims to improve parental reflective functioning (RF) and bonding.

Background: The early years of a child's life, including pregnancy, are vital for healthy physical and emotional development. Read More

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http://dx.doi.org/10.1080/02646838.2020.1786036DOI Listing
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