7,065 results match your criteria Child's Nervous System[Journal]


Ante-natal counseling in phacomatoses.

Childs Nerv Syst 2020 Jul 5. Epub 2020 Jul 5.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objectives: Phacomatoses are a group of neuro-oculo-cutaneous syndromes/ neurocutaneous disorders, involving structures arising from the embryonic ectoderm. Most of phacomatoses including the most common ones:, neurofibromatosis type I and type II (NF1, NF2) and tuberosclerosis complex (TSC), are autosomal dominant genetic disorders with full penetrance and variable expression. As no effective treatment exists, the only way to prevent the disease, is by prenatal genetic diagnosis (either chorionic villus sampling-CVS or amniocentesis-AC) and termination of pregnancy or performing preimplantation genetic testing (PGT). Read More

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http://dx.doi.org/10.1007/s00381-020-04776-3DOI Listing

Cervical myelomeningocele with CSF leakage: a case-based review.

Childs Nerv Syst 2020 Jul 4. Epub 2020 Jul 4.

Neurosurgery Department, Hospital Regional Universitario de Málaga, Málaga, Spain.

Background: The cystic spinal dysraphism of the cervical and upper thoracic region (CDCT) accounts for only 3.9 to 8% of spina bifida cystica lesions. The presence of external cerebrospinal fluid (CSF) leakage is infrequent and very few authors have reported about surgical complications. Read More

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http://dx.doi.org/10.1007/s00381-020-04743-yDOI Listing

The impact of social distancing on pediatric neurosurgical emergency referrals during the COVID-19 pandemic: a prospective observational cohort study.

Childs Nerv Syst 2020 Jul 3. Epub 2020 Jul 3.

Department of Neurosurgery, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1007/s00381-020-04783-4DOI Listing

Dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease) presenting as a prenatally heterotopic hamartoma.

Childs Nerv Syst 2020 Jul 3. Epub 2020 Jul 3.

Department of Pediatric Neurosurgery, Rennes University Hospital, Rennes, France.

Dysplastic gangliocytoma of the cerebellum (DGC), also called Lhermitte-Duclos disease, is a rare lesion of the posterior fossa consisting of a diffuse hypertrophy of the cerebellar cortex. DGC frequently presents in young adults and rarely in childhood. Only 3 cases have been previously described in newborns. Read More

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http://dx.doi.org/10.1007/s00381-020-04785-2DOI Listing

An executive functioning perspective in neurofibromatosis type 1: from ADHD and autism spectrum disorder to research domains.

Childs Nerv Syst 2020 Jul 3. Epub 2020 Jul 3.

Office of the Clinical Director and Medical Genetic Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

Purpose: Neurofibromatosis type 1 (NF1) is a rare monogenic disorder associated with executive function (EF) deficits and heightened risk for attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). The goal of this paper is to understand how EFs provide a common foundation to understand vulnerabilities for ADHD and ASD within NF1.

Methods: A literature review and synthesis was conducted. Read More

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http://dx.doi.org/10.1007/s00381-020-04745-wDOI Listing

Fronto-orbital advancement in a patient with Marshall-Smith syndrome: a case report and review of the literature.

Childs Nerv Syst 2020 Jul 2. Epub 2020 Jul 2.

Department of Plastic and Reconstructive Surgery, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.

Objective: The present report aimed to document the clinical features of a case of Marshall-Smith syndrome (MSS), an extremely rare embryonic developmental disorder with associated craniosynostosis.

Patient And Method: We presented herein a case of a 2-year-old female patient with MSS who underwent fronto-orbital advancement for multisuture craniosynostosis.

Results: The patient's proptosis improved after surgery, and no further surgical intervention was required for corneal exposure. Read More

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http://dx.doi.org/10.1007/s00381-020-04741-0DOI Listing

Adamantinomatous craniopharyngioma: advances in proteomic research.

Childs Nerv Syst 2020 Jul 2. Epub 2020 Jul 2.

UOC Neurochirurgia Infantile, Dipartimento di Scienze dell'Invecchiamento, Neurologiche, Ortopediche e della Testa-Collo; Fondazione Policlinico Universitario A. Gemelli - IRCCS, Università Cattolica del Sacro Cuore, Largo Gemelli 1, 00168, Rome, Italy.

Background: Many efforts have been performed in the last decade to accomplish the genomic and proteomic characterization of pediatric adamantinomatous craniopharyngioma with the purpose to elucidate the molecular mechanisms underlying the onset and development of this pediatric brain tumor, its high recurrence rate, and, although classified as a histologically benign neoplasm, its aggressive behavior.

Methods: The focus of this review is to perform the new comparison of the proteomic profiles of the solid component and the intracystic fluid of adamantinomatous craniopharyngioma based on our previous results, obtained by both the top-down and the bottom-up proteomic approaches, to disclose differences and similarities, and to discuss the results in the context of the most recent literature.

Results And Conclusions: Proteins and peptides identified in the cyst fluid and in the solid component of adamantinomatous craniopharyngioma (AC) include beyond markers of inflammation (i. Read More

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http://dx.doi.org/10.1007/s00381-020-04750-zDOI Listing

Letter to the editor regarding "Selective dorsal rhizotomy for spasticity of genetic etiology".

Childs Nerv Syst 2020 Jul 2. Epub 2020 Jul 2.

Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, 110029, India.

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http://dx.doi.org/10.1007/s00381-020-04787-0DOI Listing

Post-mortem histopathology of a pediatric brain after bilateral DBS of GPI for status dystonicus: case report and review of the literature.

Childs Nerv Syst 2020 Jul 2. Epub 2020 Jul 2.

Pediatric Anesthesiology and Intensive Care Unit, Children's Hospital A. Meyer-University of Florence, Florence, Italy.

Purpose: To investigate the effects of deep brain stimulation (DBS) electrodes on the brain of a dystonic pediatric patient submitted to bilateral DBS of the globus pallidus internus (GPI).

Methods: An 8-year-old male patient underwent bilateral DBS of GPI for status dystonicus. He died 2 months later due to multiorgan failure triggered by bacterial pneumonia. Read More

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http://dx.doi.org/10.1007/s00381-020-04761-wDOI Listing

A boy with a congenital cerebellar mass.

Childs Nerv Syst 2020 Jul 1. Epub 2020 Jul 1.

Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Purpose: Tumorigenesis of medulloblastoma is believed to be associated with granule cell progenitor neurogenesis of the cerebellum. Nevertheless, congenital medulloblastomas are rarely found. Here, we report a case of congenital medulloblastoma that showed spontaneous albeit transient regression. Read More

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http://dx.doi.org/10.1007/s00381-020-04767-4DOI Listing

Epilepsy in NF1: a systematic review of the literature.

Childs Nerv Syst 2020 Jul 1. Epub 2020 Jul 1.

Pediatric Psychiatry and Neurology, Department of Neuroscience, Santobono-Pausilipon Children's Hospital, Naples, Italy.

Epilepsy is one of the possible neurological manifestations of the neurofibromatosis type 1 (NF1) that represents the most common neurocutaneous disorder. We performed a systematic review of the literature on epilepsy associated with NF1 since 1995 in order to better define prevalence and describe type and causes of seizures. Data on type, nature of studies, number of patients, gender, and inheritance of NF1 were recorded as well as data on causes, type, EEGs, brain imaging, intellectual disability (ID), surgical treatment, and outcome of epilepsy. Read More

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http://dx.doi.org/10.1007/s00381-020-04710-7DOI Listing

Management of spinal deformities and tibial pseudarthrosis in children with neurofibromatosis type 1 (NF-1).

Childs Nerv Syst 2020 Jul 1. Epub 2020 Jul 1.

Altona Children's Hospital - AKK/UKE, Bleickenallee 38, 22763, Hamburg, Germany.

The skeletal system is affected in up to 60% of patients with neurofibromatosis type 1. The most commonly observed entities are spinal deformities and tibial dysplasia. Early recognition of radiologic osseous dystrophy signs is of utmost importance because worsening of the deformities without treatment is commonly observed and surgical intervention is often necessary. Read More

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http://dx.doi.org/10.1007/s00381-020-04775-4DOI Listing

Multisystem disease including stroke, epilepsy, dystonia, noncompaction, and kidney agenesis requires genetic work-up.

Authors:
Josef Finsterer

Childs Nerv Syst 2020 Jul 1. Epub 2020 Jul 1.

Krankenanstalt Rudolfstiftung, Messerli Institute, Postfach 20, 1180, Vienna, Austria.

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http://dx.doi.org/10.1007/s00381-020-04781-6DOI Listing

C2 spinal nerve tumors in young adults: report of two cases and review of the literature.

Childs Nerv Syst 2020 Jul 1. Epub 2020 Jul 1.

Almazov National Medical Research Centre, Akkuratova str. 2, St. Petersburg, Russian Federation.

C2 spinal nerve schwannomas are rarely encountered, especially in children and young adults. Due to their localization surgical management encompasses a number of distinctive features. We describe two cases of C2 spinal nerve tumors, schwannoma and neurofibroma, in patients aged 13 and 17, respectively. Read More

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http://dx.doi.org/10.1007/s00381-020-04777-2DOI Listing

Current status of MEK inhibitors in the treatment of plexiform neurofibromas.

Childs Nerv Syst 2020 Jun 30. Epub 2020 Jun 30.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, 10 Center Drive, Building 10, Room 1-3752, Bethesda, MD, 20892, USA.

Background: Neurofibromatosis type 1 (NF1)-related plexiform neurofibromas (pNF) can be debilitating and until recently, surgery was the only potentially effective therapy for these tumors.

Methods: We review critical steps in the path towards the FDA approval of the first medical therapy for NF1 pNF and the current status of MEK inhbitor therapy.

Results: Sustained efforts by the NF community have resulted in a detailed understanding of the natural history and biology of NF1-related peripheral nerve sheath tumors. Read More

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http://dx.doi.org/10.1007/s00381-020-04731-2DOI Listing

Genetic basis of neurofibromatosis type 1 and related conditions, including mosaicism.

Childs Nerv Syst 2020 Jun 29. Epub 2020 Jun 29.

Department of Human Genetics, University of Leuven, Herestraat 49, 3000, Leuven, Belgium.

Introduction: Neurofibromatosis type 1 (NF1) is a frequent autosomal dominant disorder characterised by café-au-lait maculae (CALM), skinfold freckling, iris Lisch nodules and benign peripheral nerve sheath tumours (neurofibromas).

Mechanism: The NF1 gene is a tumour suppressor gene and NF1 individuals have an increased risk for a long list of tumours, all resulting from a second hit in the normal copy of the NF1 gene. Remarkably, some non-tumour phenotypes such as CALM and pseudarthrosis are also caused by a "second hit". Read More

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http://dx.doi.org/10.1007/s00381-020-04771-8DOI Listing

New treatment modalities in NF-related neuroglial tumors.

Childs Nerv Syst 2020 Jun 29. Epub 2020 Jun 29.

Division of Radiology, Children's National Hospital, 111 Michigan Ave, NW, Washington, DC, 20010, USA.

The management of low-grade gliomas (LGGs) and other neuroglial tumors in children with neurofibromatosis type 1 (NF1) has not changed over the past 2-3 decades. With the widespread utilization of chemotherapy for younger children with progressive LGGs, outcomes have been good for most patients who have required treatment. However, some may progress after the initiation of chemotherapy and others, although radiographically responding or with stable disease, may develop progressive neurologic and visual deterioration. Read More

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http://dx.doi.org/10.1007/s00381-020-04704-5DOI Listing

Fetal therapy for congenital hydrocephalus-where we came from and where we are going.

Childs Nerv Syst 2020 Jun 29. Epub 2020 Jun 29.

Neurosurgery Division, Department of Neurology, State University of Campinas (UNICAMP), Campinas, SP, Brazil.

Despite unfavorable outcomes during the early experience with in utero intervention for congenital hydrocephalus, improvements in prenatal diagnosis, patient selection, and fetal surgery techniques have led to a renewed interest in fetal intervention for congenital hydrocephalus. Research studies and clinical evidence shows that postnatal cerebrospinal fluid diversion to release intraventricular pressure and cerebral mantle compression usually arrives late to avoid irreversible brain damage. Make sense to decompress those lateral ventricles as soon as possible during the intrauterine life when hydrocephalus is antenatally detected. Read More

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http://dx.doi.org/10.1007/s00381-020-04738-9DOI Listing

Combined microsurgical fluorescence for optimizing resection in refractory empyema and cerebritis.

Childs Nerv Syst 2020 Jun 29. Epub 2020 Jun 29.

Department of Neurosurgery, University Hospital Vírgen del Rocío, Sevilla, Sevilla, Spain.

Purpose: Due to the generalization of new microsurgical equipment, intraoperative fluorescence techniques have extended in neurosurgical practice, mainly in neurovascular and neuro-oncology patients. The aim of identifying pathological tissue and also differentiating from the normal brain helps neurosurgeons to approach other kinds of intracranial entities such as infections.

Methods: It is described in the case of an 11-year-old patient who underwent a subdural empyema by performing a craniotomy and evacuation of the purulent collection. Read More

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http://dx.doi.org/10.1007/s00381-020-04762-9DOI Listing

Clinical features associated with the development of hydrocephalus following TBI in the paediatric age group.

Childs Nerv Syst 2020 Jun 29. Epub 2020 Jun 29.

Department of Neurosurgery, University Hospital Wales, 4th Floor, Heath Park Way, Cardiff, CF14 4XW, UK.

Introduction: Predictive factors for post-traumatic hydrocephalus (PTH) in adults have been elucidated but remain uncertain for children. We aimed to identify the prevalence of PTH in paediatric patients and identify clinical/radiological factors which may increase the probability of children developing PTH.

Methods: This was a retrospective study of all patients < 16 years old admitted to our unit with traumatic brain injury (TBI) between March 2013 and June 2018, 108 patients in total. Read More

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http://dx.doi.org/10.1007/s00381-020-04764-7DOI Listing

Occult tethered cord syndrome: a reversible cause of paraparesis not to be missed.

Childs Nerv Syst 2020 Jun 28. Epub 2020 Jun 28.

Second Department of Psychiatry, School of Medicine, University General Hospital "Attikon", Athens, Greece.

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http://dx.doi.org/10.1007/s00381-020-04768-3DOI Listing

Preoperative planning with a 3D model and repair of sphenoid dysplasia: a technical note.

Childs Nerv Syst 2020 Jun 27. Epub 2020 Jun 27.

Department of Maxillofacial and Oral Surgery, University Medical Centre Ljubljana, Ljubljana, Slovenia.

Introduction: Sphenoid dysplasia is a distinctive marker of neurofibromatosis 1. It is a malformation of the sphenoid bone characterized by an enlargement of the superior orbital fissure, through which the intracranial content herniates, leading to a facial disfigurement and exophthalmos and to a potential visual deterioration. Surgical treatment has the aim of separating the intracranial from the intraorbital space. Read More

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http://dx.doi.org/10.1007/s00381-020-04759-4DOI Listing

Pudendal mapping of S1 rootlets in a functional posterior rhizotomy: when an S1 posterior root shows a high pudendal dorsal action potential-a technical note.

Authors:
Nobuhito Morota

Childs Nerv Syst 2020 Jun 27. Epub 2020 Jun 27.

Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-Ku, Sagamihara, Kanagawa, 252-0375, Japan.

Background: The standard level for lesioning in a functional posterior rhizotomy (FPR) ranges from L2 to S1/S2. Lesioning of the S1 and S2 rootlets strongly correlates with a reduction in ankle spasticity. In the Japanese population, the S2 root often shows the highest dorsal root action potentials (DAPs) in the afferent fibers of the pudendal nerve and is not lesioned to preserve postoperative urinary function. Read More

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http://dx.doi.org/10.1007/s00381-020-04751-yDOI Listing

Clinical features and long-term outcomes of pediatric spinal cord cavernous malformation-a report of 18 cases and literature review.

Childs Nerv Syst 2020 Jun 26. Epub 2020 Jun 26.

Medical School of Nankai University, No. 94, Weijin Road, Naikai District, Tianjin, 300071, People's Republic of China.

Purpose: Pediatric intramedullary spinal cord cavernous malformation (ISCM) is a rare vascular disease with unclear natural history and long-term outcomes. We aim to determine the demographics, hemorrhagic risk, and long-term outcomes of this rare entity.

Methods: A retrospective review of clinical data and treatment outcomes of pediatric patients treated with ISCM in our institution from 3/2000 to 3/2017 was conducted. Read More

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http://dx.doi.org/10.1007/s00381-020-04700-9DOI Listing

Peritoneal insertion of shunts in children: comparison between trocar and laparoscopically guided insertion.

Childs Nerv Syst 2020 Jun 26. Epub 2020 Jun 26.

Department of Pediatric Neurosurgery, Dana Children's Hospital, Tel-Aviv Medical Center, 6 Weizman Street, 64239, Tel Aviv, Israel.

Purpose: Ventriculo-peritoneal shunts are commonly used for treating hydrocephalus for all age groups. There are 3 main methods for shunt placement into the peritoneum: mini laparotomy, laparoscopically guided, or percutaneously with a trocar. There is limited literature comparing between these techniques in the pediatric population, and specifically-the trocar has not been compared with laparoscopy. Read More

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http://dx.doi.org/10.1007/s00381-020-04760-xDOI Listing

Abnormal spindle-like microcephaly-associated (ASPM) gene expression in posterior fossa brain tumors of childhood and adolescence.

Childs Nerv Syst 2020 Jun 26. Epub 2020 Jun 26.

Department of Pediatrics, Pediatric Oncology Institute-GRAACC, Federal University of São Paulo, São Paulo, SP, Brazil.

Purpose: In neurogenesis, ASPM (abnormal spindle-like microcephaly-associated) gene is expressed mainly in the ventricular zone of posterior fossa and is the major determinant in the cerebral cortex. Besides its role in embryonic development, ASPM overexpression promotes tumor growth, including central nervous system (CNS) tumors. This study aims to investigate ASPM expression levels in most frequent posterior fossa brain tumors of childhood and adolescence: medulloblastoma (MB), ependymoma (EPN), and astrocytoma (AS), correlating them with clinicopathological characteristics and tumor solid portion size. Read More

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http://dx.doi.org/10.1007/s00381-020-04740-1DOI Listing

Transcallosal-lateral ventricle-choroid fissure approach for excising large pineal region tumors extending into the third ventricle: experience in 15 pediatric cases.

Childs Nerv Syst 2020 Jun 25. Epub 2020 Jun 25.

Department of Neurosurgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530007, Guangxi, People's Republic of China.

Pineal region is deep located and tightly connected with surrounding important nerves, blood vessels, and other critical structure. Tumors in the regions are more commonly observed in children with complex pathology, difficult surgery, and poor prognosis. However, excision surgery on large tumor in the pineal region and extending into the third ventricle is characterized by high difficulty and uneasy treatment. Read More

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http://dx.doi.org/10.1007/s00381-020-04742-zDOI Listing

Frequency distribution in intraoperative stimulation-evoked EMG responses during selective dorsal rhizotomy in children with cerebral palsy-part 2: gender differences and left-biased asymmetry.

Childs Nerv Syst 2020 Jun 25. Epub 2020 Jun 25.

Division of Pediatric Neurosurgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 13353, Berlin, Germany.

Introduction: Spinal reflexes reorganize in cerebral palsy (CP), producing hyperreflexia and spasticity. CP is more common among male infants, and gender might also influence brain and spinal-cord reorganization. This retrospective study investigated the frequency of higher-graded EMG responses elicited by electrical nerve-root stimulation during selective dorsal rhizotomy (SDR), prior to partial nerve- root deafferentation, considering not only segmental level and body side, but also gender. Read More

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http://dx.doi.org/10.1007/s00381-020-04735-yDOI Listing

Midface distraction osteogenesis using a modified external device and 3D virtual simulation: technical note.

Childs Nerv Syst 2020 Jun 25. Epub 2020 Jun 25.

Department of Oral and Maxillofacial Surgery, School of Dentistry, University of São Paulo, São Paulo, Brazil.

Introduction/background: Distraction osteogenesis (DO) with an external distraction device such as the rigid external distraction frame has become an established method for treating midface hypoplasia in faciocraniosynostosis. It allows for greater advancement of the midface in comparison with traditional Le Fort III osteotomies, associated or not with fronto-orbital osteotomies (Le Fort IV). However, the forward movement of the bone segments may not always be performed obeying an ideal distraction vector, resulting in asymmetries, anterior open bite, and loosening of screws. Read More

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http://dx.doi.org/10.1007/s00381-020-04730-3DOI Listing

Craniofacial bone alterations in patients with neurofibromatosis type 1.

Childs Nerv Syst 2020 Jun 25. Epub 2020 Jun 25.

Université Claude Bernard Lyon 1, 43 Boulevard du 11 Novembre 1918, 69100, Villeurbanne, France.

Osseous manifestations of neurofibromatosis 1 (NF-1) occur in a minority of the affected subjects but may be because of significant clinical impairment. Typically, they involve the long bones, commonly the tibia and the fibula, the vertebrae, and the sphenoid wing. The pathogenesis of NF-1 focal osseous lesions and its possible relationships with other osseous NF-1 anomalies leading to short stature are still unknown, though it is likely that they depend on a common mechanism acting in a specific subgroup of NF-1 patients. Read More

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http://dx.doi.org/10.1007/s00381-020-04749-6DOI Listing

Neurological manifestations of pediatric multi-system inflammatory syndrome potentially associated with COVID-19.

Childs Nerv Syst 2020 Jun 25. Epub 2020 Jun 25.

Department of Neurosurgery, Mount Sinai Health System, 1468 Madison Avenue, Annenberg 8th Floor, New York, NY, 10029, USA.

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http://dx.doi.org/10.1007/s00381-020-04755-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314616PMC

Correction to: Stingray spear injury to the pediatric spinal cord: case report and review of the literature.

Childs Nerv Syst 2020 Jun 25. Epub 2020 Jun 25.

Servicio de Neurocirugía, Hospital Nacional de Niños, "Dr. Carlos Sáenz Herrera", San José, Costa Rica.

The original version of this article unfortunately contained an error in the spelling of the last name of one of the co-authors. The corresponding author did not notice that the last name of one of the co-authors, Nathan Shlobin, was misspelled as "Schlobin". The correct spelling of his last name is "Shlobin". Read More

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http://dx.doi.org/10.1007/s00381-020-04739-8DOI Listing

Henry Gray (1827-1861): the great author of the most widely used resource in medical education.

Childs Nerv Syst 2020 Jun 24. Epub 2020 Jun 24.

Faculty of Medicine, Department of Anatomy, Istanbul University, Istanbul, Turkey.

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http://dx.doi.org/10.1007/s00381-020-04748-7DOI Listing

Long term outcome of Selective Dorsal Rhizotomy for the management of childhood spasticity-functional improvement and complications.

Childs Nerv Syst 2020 Jun 23. Epub 2020 Jun 23.

Division of Pediatric Neurosurgery, Children's Hospital of British Columbia, Vancouver, Canada.

Background: Selective dorsal rhizotomy (SDR) for the management of lower extremity spasticity is a surgical technique that has existed since the 1900s. While much evidence supports its efficaciousness in reducing tone in the short term, limited information exists detailing the long-term outcome and evolution over time of patients undergoing SDR.

Methods: All publications with 10 years or more of outcome data on patients undergoing SDR were identified from Medline and Embase databases using the search term "Rhizotmy. Read More

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http://dx.doi.org/10.1007/s00381-020-04747-8DOI Listing

Frequency distribution in intraoperative stimulation-evoked EMG responses during selective dorsal rhizotomy in children with cerebral palsy-part 1: clinical setting and neurophysiological procedure.

Childs Nerv Syst 2020 Jun 23. Epub 2020 Jun 23.

Division of Pediatric Neurosurgery, Universitätsklinikum Bonn, 53127, Bonn, Germany.

Introduction: Selective dorsal rhizotomy (SDR) consists of microsurgical partial deafferentation of sensory nerve roots (L1-S2). It is primarily used today in decreasing spasticity in young cerebral palsy (CP) patients. Intraoperative monitoring (IOM) is an essential part of the surgical decision-making process, aimed at improving functional results. Read More

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http://dx.doi.org/10.1007/s00381-020-04734-zDOI Listing

Transsphenoidal approach in children with partially or minimally developed sphenoid sinus.

Childs Nerv Syst 2020 Jun 23. Epub 2020 Jun 23.

Department of Neurosurgery, International Neuroscience Institute, Rudolf Pichlmayr Str. 4, 30625, Hannover, Germany.

Object: The transsphenoidal approach is guided by a few fundamental anatomic landmarks. Pneumatization of the SS is variable, and this plays a key role in accessing the sella floor and other skull base structures. It may be absent or minimally present in both adult and, often, pediatric population, making surgical approach more difficult than usual. Read More

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http://dx.doi.org/10.1007/s00381-020-04757-6DOI Listing

An online tumor board with international neurosurgical collaboration guides surgical decision-making in Western Kenya.

Childs Nerv Syst 2020 Jun 22. Epub 2020 Jun 22.

Department of Surgery, Tenwek Hospital, Bomet, Kenya.

Telecollaboration via web-based platforms has emerged as a tool to relieve constraints on the establishment of tumor boards for neurosurgical oncology. Challenging tumor cases arising in low- and middle-income countries may benefit from the use of such models. The case of a 5-year-old boy presenting in Western Kenya with a challenging tumor and symptomatic hydrocephalus was presented on a novel web platform to a multi-national audience of neurosurgeons. Read More

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http://dx.doi.org/10.1007/s00381-020-04744-xDOI Listing

Sturge-Weber syndrome: an update on the relevant issues for neurosurgeons.

Childs Nerv Syst 2020 Jun 21. Epub 2020 Jun 21.

Neurochirurgia Infantile, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Purpose: Sturge-Weber syndrome (SWS) is a neurocutaneous facomatosis characterized by facial and leptomeningeal angioma, glaucoma, seizures, and neurological disability. Therefore, a challenging multidisciplinary interaction is required for its management. The goal of this paper is to review the main aspects of SWS and to present an illustrative pediatric series. Read More

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http://dx.doi.org/10.1007/s00381-020-04695-3DOI Listing

Options and strategies for hearing restoration in pediatric neurofibromatosis type 2.

Childs Nerv Syst 2020 Jun 21. Epub 2020 Jun 21.

Division of Neurotology (HM and WHS) and Division of Neurosurgery (GUM and GPL), House Ear Institute, 2100 W 3rd Street, Suite 111, Los Angeles, CA, 90057, USA.

Purpose: In this article, we will review the mechanisms and natural history of hearing loss in neurofibromatosis type 2 (NF2) and discuss the hearing outcomes with different rehabilitation options.

Methods: Review of the published literature.

Results: NF2 is a rare autosomal dominant syndrome characterized by vestibular schwannomas and other intracranial and spinal tumors. Read More

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http://dx.doi.org/10.1007/s00381-020-04721-4DOI Listing

Spinal manifestations of Neurofibromatosis type 1.

Childs Nerv Syst 2020 Jun 20. Epub 2020 Jun 20.

The Gilbert Israeli International Neurofibromatosis Center (GIINFC), Tel Aviv, Israel.

Background: Neurofibromatosis type 1 (NF1) patients may present a wide spectrum of spinal pathologies. Osseous changes may lead to severe deformities with significant implications on growth and quality of life. Neurogenic tumors and soft tissue abnormalities may cause neuropathic pain and dysfunction ranging from minor paresthesias to profound motor and sensory deficits. Read More

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http://dx.doi.org/10.1007/s00381-020-04754-9DOI Listing

Fusiform dilatation of internal carotid artery after pterional but not subfrontal craniotomy in 6 patients.

Childs Nerv Syst 2020 Jun 20. Epub 2020 Jun 20.

Department of Neurosurgery, Lille University Hospital, rue E. Laine, 59037, Lille, France.

Purpose: Our study aimed to evaluate potential risk factors for the development of FDICA after suprasellar tumor resection.

Materials And Method: After reviewing all cases of pediatric patients who benefited from a suprasellar lesion resection in our two medical institutions, we found 6 patients with a FDICA. Surgical approach strategy (pterional or subfrontal approaches) was noted. Read More

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http://dx.doi.org/10.1007/s00381-020-04753-wDOI Listing

Spontaneous resolution of large subdural hematoma with midline shift: a case report.

Childs Nerv Syst 2020 Jun 20. Epub 2020 Jun 20.

Departments of Pediatric Surgery and Neurosurgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.

Subdural hematomas with mass effect and midline shift are typically offered urgent surgical evacuation. The authors report a 6-month-old baby who was referred for macrocephaly and found to have a large subdural hematoma with midline shift. Given her lack of symptoms and normal neurological examination, the patient was observed without neurosurgical intervention. Read More

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http://dx.doi.org/10.1007/s00381-020-04733-0DOI Listing

Intrathecal baclofen for hereditary spastic paraplegia (HSP).

Childs Nerv Syst 2020 Jun 19. Epub 2020 Jun 19.

Division of Neurosurgery, The Hospital for Sick Children, 555 University Ave, Suite 1503, Toronto, ON, M5G 1X8, Canada.

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http://dx.doi.org/10.1007/s00381-020-04736-xDOI Listing

Role of high-resolution ultrasound in detection and monitoring of peripheral nerve tumor burden in neurofibromatosis in children.

Childs Nerv Syst 2020 Jun 19. Epub 2020 Jun 19.

Department of Neurology and Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.

Purpose: Peripheral nerve sheath tumors are hallmark findings in neurofibromatosis types 1 and 2. With increasing size, they typically lead to neurological symptoms, and NF1 patients have a lifetime risk of 8-13% for developing malignant peripheral nerve sheath tumors. Medical imaging is therefore highly needed for early detection and exact localization of symptomatic or potentially malignant tumors. Read More

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http://dx.doi.org/10.1007/s00381-020-04718-zDOI Listing

A systematic review of ongoing clinical trials in optic pathway gliomas.

Childs Nerv Syst 2020 Jun 18. Epub 2020 Jun 18.

Department of Neurosurgery, Great Ormond Street Hospital, London, UK.

Introduction: Optic pathway gliomas (OPGs), also known as Visual Pathway Gliomas, are insidious, debilitating tumours. They are most commonly WHO grade 1 pilocytic astrocytomas and frequently occur in patients with neurofibromatosis type 1. The location of OPGs within the optic pathway typically precludes complete resection or optimal radiation dosing, hence outcomes remain poor compared to many other low-grade gliomas. Read More

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http://dx.doi.org/10.1007/s00381-020-04724-1DOI Listing

A case of medulloblastoma in a patient with fetal ventricular enlargement.

Childs Nerv Syst 2020 Jun 18. Epub 2020 Jun 18.

Department of Neurosurgery, Kansai Medical University, 2-5-1 Shinmachi, Hirakata City, Osaka, 573-1010, Japan.

Medulloblastoma is the second-most common malignant tumor in children. Medulloblastoma has been categorized into four distinct molecular subgroups: WNT, sonic hedgehog (SHH), group 3, and group 4. We report on a male child with medulloblastoma, in whom an enlarged ventricle was diagnosed in utero. Read More

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http://dx.doi.org/10.1007/s00381-020-04725-0DOI Listing

Securing CSF catheters to the skin: from sutures and bolt system to subcutaneous anchoring device towards zero complications.

Childs Nerv Syst 2020 Jun 17. Epub 2020 Jun 17.

Pediatric Neurosurgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli, 8, 00168, Rome, Italy.

Introduction: Securing the catheter to the skin either with sutures or staples and to the skull with bolt system still represents the most common options in the management of CSF external drainage. However, these options bear an unavoidable risk of complications. This problem is common to vascular accesses and has been successfully overcome with the introduction of device for subcutaneous anchoring (SecurAcath®, Interrad Medical, Inc. Read More

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http://dx.doi.org/10.1007/s00381-020-04737-wDOI Listing

Managing NF2-associated vestibular schwannomas in children and young adults: review of an institutional series regarding effects of surgery and bevacizumab on growth rates, tumor volume, and hearing quality.

Childs Nerv Syst 2020 Jun 16. Epub 2020 Jun 16.

Department of Neurosurgery, University Hospital Tübingen, Tübingen, Germany.

We reviewed our experience in managing of NF2-associated vestibular schwannoma (VS) in children and young adults regarding the effect of surgery and postoperative bevacizumab treatment. A total of 579 volumetric and hearing data sets were analyzed. The effect of surgery on tumor volume and growth rate was investigated in 46 tumors and on hearing function in 39 tumors. Read More

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http://dx.doi.org/10.1007/s00381-020-04728-xDOI Listing

Neurophysiological mechanisms of hypertonia and hypotonia in children with spastic cerebral palsy: surgical implications.

Childs Nerv Syst 2020 Jun 16. Epub 2020 Jun 16.

Neurosurgeon, Department of Neurosurgery, General Hospital of Athens "G. Gennimatas", Medical School, University of Athens, Athens, Greece.

Mechanism of hypertonia in cerebral palsy children is dual: a neural component due to spasticity (velocity dependent) and a biomechanical component linked to soft tissue changes. Their differentiation-which might be clinically difficult-is however crucial, as only the first component will respond to anti-spastic treatments, the second to physiotherapy. Furthermore, spasticity is frequently associated with dystonia, which is a sustained hypertonic state induced by attempts at voluntary motion. Read More

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http://dx.doi.org/10.1007/s00381-020-04732-1DOI Listing

Central nervous system high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR)-case-based reviews.

Childs Nerv Syst 2020 Jun 15. Epub 2020 Jun 15.

Neurochirurgia Infantile, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Introduction: High-grade neuroepithelial tumor with BCOR alteration (HGNET BCOR) has been recently classified as a new category of tumors among those previously known as PNET. They are molecularly characterized by the mutation of the BCOR gene, a corepressor of BCL6 a gene (which has an important role in immune responses). Only case reports and very small series have been published so far; therefore, their behavior and management are still under investigation. Read More

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http://dx.doi.org/10.1007/s00381-020-04692-6DOI Listing