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    6144 results match your criteria Child's Nervous System[Journal]

    1 OF 123

    Valproic acid treatment response in vitro is determined by TP53 status in medulloblastoma.
    Childs Nerv Syst 2018 May 22. Epub 2018 May 22.
    Pediatrics Oncology Institute-GRAACC (Grupo de Apoio ao Adolescente e à Criança com Câncer) /UNIFESP (Federal University of Sao Paulo), Rua Botucatu, 743, Floor 8 - Genetics Laboratory, Vila Clementino, São Paulo, SP, Zip Code 04023-062, Brazil.
    Purpose: Histone deacetylate inhibitors (HDACi), as valproic acid (VA), have been reported to enhance efficacy and to prevent drug resistance in some tumors, including medulloblastoma (MB). In the present study, we investigated VA role, combined to cisplatin (CDDP) in cell viability and gene expression of MB cell lines.

    Methods: Dose-response curve determined IC values for each treatment: (1) VA single, (2) CDDP single, and (3) VA and CDDP combined. Read More

    Correction to: Management of split cordmalformation in children: the Lyon experience.
    Childs Nerv Syst 2018 May 17. Epub 2018 May 17.
    Department of Pediatric Neurosurgery, Hôpital Femme Mère Enfant, Hospice Civil de Lyon, 59 Boulevard Pinel, 69677, Lyon Cedex, France.
    The original version of this article unfortunately contained an error. The authors have been published with inverted given and family names. Given in this article are the corrected author names. Read More

    Surgery for subependymal giant cell astrocytomas in children with tuberous sclerosis complex.
    Childs Nerv Syst 2018 May 15. Epub 2018 May 15.
    Department of Pediatric Neurosurgery, Fondation Ophtalmologique A. de Rothschild, Paris, France.
    Objective: Subependymal giant cell astrocytomas (SEGAs) are low-grade intraventricular glial tumors that develop in 10-15% of patients with tuberous sclerosis complex; they often cause hydrocephalus and are potentially accessible to a surgical treatment. Our aim is to evaluate morbidity and results after surgery in symptomatic and asymptomatic patients.

    Method: We present a retrospective series of 18 pediatric patients operated on for SEGA between 2006 and 2016 at our institution. Read More

    Quantitative analysis of cranial-orbital changes in infants with anterior synostotic plagiocephaly.
    Childs Nerv Syst 2018 May 14. Epub 2018 May 14.
    Polo scienze delle immagini, di laboratorio ed infettivologiche Area diagnostica per immagini Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.
    Purpose: The effects of premature fusion of one coronal suture cause skull and orbital alterations in term of side-to-side asymmetry. This study aimed to quantify the cranio-orbital complex changes related to the severity of skull base dysmorphology in patients with unicoronal synostosis.

    Methods: Twenty-four infants affected by unicoronal synostosis were subdivided in three subgroups according to the severity of skull base deformity and their high-resolution CT images were quantitatively analyzed (groups IIa, IIb, III). Read More

    Open resection of hypothalamic hamartomas for intractable epilepsy revisited, using intraoperative MRI.
    Childs Nerv Syst 2018 May 11. Epub 2018 May 11.
    Department of Neurosurgery, Alder Hey Children's NHS Foundation Trust, Liverpool, L12 2AP, UK.
    Introduction: Hypothalamic hamartomas (HHs) are rare non-neoplastic lesions which cause drug-resistant epilepsy with associated behavioural, psychiatric and endocrine issues. With the development of new minimally invasive techniques for the treatment of HH, there is a need to reappraise the effectiveness and safety of each approach. We review the outcomes of HH patients treated surgically, utilizing intraoperative magnetic resonance imaging (IOMRI), by a team of Alder Hey NHS Foundation Trust tumour and epilepsy neurosurgeons since 2011. Read More

    Evaluation of parental and surgeon stressors and perceptions of distraction osteogenesis in pediatric craniofacial patients: a cross-sectional survey study.
    Childs Nerv Syst 2018 May 11. Epub 2018 May 11.
    Division of Plastic Surgery, Children's Hospital of Philadelphia, The University of Pennsylvania, Colket Translational Research Building, 9th Floor, Philadelphia, PA, 19104, USA.
    Purpose: There is a paucity of literature on how limitations of distraction osteogenesis (DO) are perceived by physicians and parents of pediatric patients. Specifically understanding which features of DO are most concerning to these two groups may better inform parent education, as well as direct improvements in distraction protocols and devices.

    Method: Parents/guardians of patients (between January 2016 and October 2017) being treated with craniofacial distraction were recruited to complete a survey regarding level of stress (1 = not stressful, 9 = maximally stressful) associated with eight features of DO. Read More

    Hearing loss in PHACE syndrome: clinical and radiologic findings.
    Childs Nerv Syst 2018 May 10. Epub 2018 May 10.
    Department of Otolaryngology Head and Neck Surgery, Division of Pediatric Otolaryngology, University of California, San Francisco, 550 16th St, San Francisco, CA, 94158, USA.
    Purpose: To characterize the types of hearing loss, auditory-related imaging findings, and hemangioma characteristics in patients with Posterior fossa malformations, Hemangiomas, Arterial anomalies, Cardiac defects, and abnormalities of the Eye (PHACE) syndrome.

    Methods: Retrospective medical records, audiologic data, and imaging review of all patients presenting to a tertiary care children's hospital with a proven diagnosis of PHACE syndrome from 2005 to 2016.

    Results: Twelve patients were identified with hearing and imaging data. Read More

    Subdural empyema due to Salmonella paratyphi B in an infant: a case report and review of literature.
    Childs Nerv Syst 2018 May 10. Epub 2018 May 10.
    Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatrics Centre, PGIMER, Chandigarh, 160012, India.
    Intracranial infection due to Salmonella is uncommon in children. Subdural empyema (SDE) is described with Salmonella typhi as a complication of meningitis. We report a 6-month-old infant with SDE secondary to Salmonella paratyphi B who had presented with prolonged fever and enlarging head. Read More

    Robot-assisted stereotactic brain biopsy: systematic review and bibliometric analysis.
    Childs Nerv Syst 2018 May 10. Epub 2018 May 10.
    Department of Neurosurgery, Great Ormond Street Hospital, London, UK.
    Introduction: Stereotactic brain biopsy represents one of the earliest applications of surgical robotics. The aim of the present systematic review and bibliometric analysis was to evaluate the literature supporting robot-assisted brain biopsy and the extent to which the scientific community has accepted the technique.

    Methods: The Cochrane and PubMed databases were searched over a 30-year period between 1st of January 1988 and 31st of December 2017. Read More

    A rare case of paediatric primary central nervous system lymphoma treated with high-dose methotrexate and rituximab-based chemoimmunotherapy and whole brain radiotherapy followed by tumour bed boost with three-dimensional conformal radiation technique.
    Childs Nerv Syst 2018 May 9. Epub 2018 May 9.
    Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
    Background: Primary central nervous system lymphomas (PCNSL) are rare in the paediatric population.

    Clinical Case: A 12-year-old boy presented to our clinic with complaints of multiple episodes of generalised tonic-clonic seizures for 1 year and gradual loss of vision in both eyes for 3 months. Baseline magnetic resonance imaging (MRI) of the brain showed a large (7. Read More

    Intraosseous schwannoma of the occipital bone: a case report.
    Childs Nerv Syst 2018 May 7. Epub 2018 May 7.
    Division of Neurosurgery, The Hospital for Sick Children, Suite 1503, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada.
    Object: Intraosseous schwanomma of the calvarium METHODS: This paper reports the case of a 7-year-old boy who presented with an intraosseous schwanomma involving the occipital bone and provides a brief overview of the literature.

    Results: The patient presented with a mass in the midline occipital region. Neuroimaging revealed a lytic lesion in the occipital bone with lack of enhancement on gadolinium MRI sequences. Read More

    Distinct demographic profile and molecular markers of primary CNS tumor in 1873 adolescent and young adult patient population.
    Childs Nerv Syst 2018 May 5. Epub 2018 May 5.
    Neuro-Oncology Disease Management Group, Tata Memorial Centre, 1129, Homi Bhabha Block, Parel, Mumbai, 400012, India.
    Introduction: We present detailed demographic profile, tumor types, and their molecular markers in adolescent and young adult (AYA) patients of age group between 15 and 39 years with primary central nervous system (PCNS) tumors, and compare with pediatric and adult patient populations.

    Methodology: Demographic- and disease-related information of 1873 PCNS tumor patients of age 15-39 years registered between 1 January 2011 and 31 December 2015 at our institution was analyzed with respect to their demographics and tumor subtypes. Various molecular markers for glial tumors and subgroup classification of medulloblastoma were evaluated for AYA, pediatric, and older adult patient populations. Read More

    Rapidly progressive fatal idiopathic hypertrophic pachymeningitis with brainstem involvement in a child.
    Childs Nerv Syst 2018 May 5. Epub 2018 May 5.
    Department of Pediatrics, Sapporo Medical University School of Medicine, South-1, West-16, Chuo-ku, Sapporo, 060-8543, Japan.
    Background: Hypertrophic pachymeningitis (HP) is a rare disorder characterized by diffuse thickening of the dura mater with resultant neurologic deficits. HP develops secondary to various conditions or idiopathically usually in adults but rarely in children.

    Case Report: We describe a 3-year-old female child with idiopathic HP. Read More

    Recurrent meningitis in children: etiologies, outcome, and lessons to learn.
    Childs Nerv Syst 2018 May 4. Epub 2018 May 4.
    Department of Internal Medicine, Division of Infectious Diseases, School of Medicine, The University of Jordan, Amman, Jordan.
    Purpose: Recurrent meningitis in children is a rare condition. However, its early recognition is important in order to prevent serious complications. This study aims to review cases of recurrent meningitis in children. Read More

    Pediatric extraspinal sacrococcygeal ependymoma (ESE): an Italian AIEOP experience of six cases and literature review.
    Childs Nerv Syst 2018 May 3. Epub 2018 May 3.
    Department of Radiology and Radiotherapy, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
    Background: Primary pediatric extraspinal sacrococcygeal ependymoma (ESE) is a very rare disease, poorly described in literature, whose diagnostic, therapeutic, and follow-up approach is still controversial.

    Methods: We describe six cases of pediatric ESE treated at Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) centers in Italy since 1983, with a review of the literature.

    Results: All six patients had primary sacrococcygeal disease (two presacral and four subcutaneous) with median age of 10 years. Read More

    Pediatric intracranial aneurysms: changes from previous studies.
    Childs Nerv Syst 2018 May 2. Epub 2018 May 2.
    Department of Neurosurgery, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan, 610041, People's Republic of China.
    Purpose: To develop a better understanding of pediatric intracranial aneurysms (PIAs).

    Methods: All PIAs treated in our center from January 2012 to April 2017 were retrospectively included. Clinical data, treatment summaries, and follow-up outcomes were retrieved and analyzed. Read More

    Enlargement of sacral subcutaneous meningocele associated with retained medullary cord.
    Childs Nerv Syst 2018 Apr 27. Epub 2018 Apr 27.
    Department of Pathology, Japan Community Health Care Organization (JCHO), Kyushu Hospital, Kitakyushu, Japan.
    Background: A retained medullary cord (RMC) is a rare closed spinal dysraphism with a robust elongated neural structure continuous from the conus and extending to the dural cul-de-sac. Four cases of RMC extending down to the base of an associated subcutaneous meningocele at the sacral level have been reported.

    Clinical Presentation: We report an additional case of RMC, in whom serial MRI examination revealed an enlargement of the meningocele associated with RMC over a 3-month period between 8 and 11 months of age, when he began to stand. Read More

    Sleep disorders in children with brain tumors: a pilot study based on a sleep disorder questionnaire.
    Childs Nerv Syst 2018 Apr 26. Epub 2018 Apr 26.
    Unit of Pediatric Radiotherapy, Centro di Riferimento Oncologico CRO, Aviano, Italy.
    Purpose: The aim of this study is to compare the prevalence of sleep disorders (SD) between children treated for brain tumors and healthy children, and to define the type of SD.

    Methods: A case-control study was performed from October 2014 to April 2015. Inclusion criteria were patients between 2 and 16 years with "cases" defined as children affected by central nervous system tumors at least 3 months after the end of treatment (surgery and/or radiotherapy and/or chemotherapy) at the time of evaluation and "controls" as healthy children. Read More

    Successful endoscopic third ventriculostomy in children depends on age and etiology of hydrocephalus: outcome analysis in 51 pediatric patients.
    Childs Nerv Syst 2018 Apr 25. Epub 2018 Apr 25.
    Long Island Jewish Medical Center, North Shore University Hospital, The Chiari Institute, Great Neck, Manhasset, NY, USA.
    Purpose: Endoscopic third ventriculostomy (ETV) has become the method of choice in the treatment of hydrocephalus. Age and etiology could determine success rates (SR) of ETV. The purpose of this study is to assess these factors in pediatric population. Read More

    Risk of mild head injury in preschool children: relationship to attention deficit hyperactivity disorder symptoms.
    Childs Nerv Syst 2018 Apr 25. Epub 2018 Apr 25.
    Department of Neurosurgery, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaraş, Turkey.
    Aim: To investigate whether there is an association between mild head injury (MHI) and attention deficit hyperactivity disorder (ADHD) symptoms in preschool children.

    Methods: The study included a patient group of 30 children aged 3-6 years with mild head trauma and a control group of 30 healthy and age- and sex-matched children. The symptoms of ADHD were evaluated using the Conners' Parent Rating Scale-Revised Long (CPRS-RL) form. Read More

    Extended endoscopic supracerebellar infratentorial (EESI) approach for a complex pineal region tumour-a technical note.
    Childs Nerv Syst 2018 Apr 23. Epub 2018 Apr 23.
    Department of Paediatric Neurosurgery, Sheffield Children's Hospital, Sheffield, UK.
    Endoscopic-assisted approaches have been shown to be a suitable alternative to the standard microscopic approach to pineal region tumours. With extension laterally into the ventricles, the 0° endoscope and microscope have significant limitations. We describe the extended endoscopic supracerebellar infratentorial (EESI) approach using angled endoscopes for a complex pineal region tumour that extended into the lateral ventricle. Read More

    Effect evaluation of methylprednisolone plus mitochondrial division inhibitor-1 on spinal cord injury rats.
    Childs Nerv Syst 2018 Apr 23. Epub 2018 Apr 23.
    The Affiliated Bayi Brain Hospital, the Army General Hospital PLA, No. 5, Nanmencang, Dongcheng District, Beijing, 100700, China.
    Purpose: To investigate the combination effect of methylprednisolone (MP) and mitochondrial division inhibitor-1 (Mdivi-1) on the neurological function recovery of rat spinal cord injury (SCI) model.

    Methods: The weight-drop method was used to establish the rat SCI model; then, rats were randomized into sham group, SCI group, MP group, Mdivi-1 group and MP+Mdivi-1 group. Motor function scores were quantified to evaluate locomotor ability; HE staining was used to assess spinal cord histopathology; tissue water content, oxidative stress, tissue mitochondrial function, neurons apoptosis, and apoptosis-related protein expression were detected. Read More

    Aggravation of seizures and status epilepticus after vagal nerve stimulation therapy: the first pediatric case and review of the literature.
    Childs Nerv Syst 2018 Apr 22. Epub 2018 Apr 22.
    Department of Neurosurgery, Gazi University School of Medicine, Ankara, Turkey.
    Background: We describe the first child with drug-resistant epilepsy in whom vagus nerve stimulation aggravated seizures and emerged status epilepticus after the increase in vagal nerve stimulation current output.

    Objective: A 13-year-old girl presented with refractory secondary generalized focal epilepsy. Vagal nerve stimulator was implanted because of drug-resistant epilepsy. Read More

    Neuropsychological impacts of indirect revascularization for pediatric moyamoya disease.
    Childs Nerv Syst 2018 Jun 20;34(6):1199-1206. Epub 2018 Apr 20.
    Department of Pediatric Neurosurgery, Severance Children's Hospital, Yonsei University College of Medicine, 50 Yonseiro, Seodaemungu, Seoul, South Korea.
    Purpose: Moyamoya disease (MMD) commonly leads to neurocognitive impairment. This study was carried out to show that temporal encephaloduroarteriosynangiosis (EDAS) has a positive neuropsychological impact on pediatric MMD patients.

    Methods: Fifty-five participants diagnosed with MMD from 2008 to 2014 were included in this retrospective study. Read More

    Role of MR spectroscopy in diagnosis of intracranial neuroenteric cyst.
    Childs Nerv Syst 2018 Apr 20. Epub 2018 Apr 20.
    Department of Neurology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, 751019, India.
    Introduction: Neuroenteric cysts are rare benign endodermal lesions of the central nervous system that result from incomplete resorption of neuroenteric canal and mostly found in cervical and upper thoracic spinal canal. Intracranial neuroenteric cysts are extra axial and commonly located anteriorly in the posterior cranial fossa. MRI demonstrates variable intensity within the lesion on T1, T2W, and DWI sequences. Read More

    Posterior cranial fossa and spinal local infections.
    Childs Nerv Syst 2018 Apr 20. Epub 2018 Apr 20.
    Pediatric Neurosurgery, Institute of Neurosurgery, Catholic University Medical School, Largo "A. Gemelli", 8, 00168, Rome, Italy.
    Object: The aim of this paper is to review the current knowledge on the management of local infections in posterior cranial fossa (PCF) and spinal surgery; the center of our paper will be the diagnosis and management of infections of the wound, the subcutaneous tissue, and muscle strata.

    Results And Conclusions: Very few papers address the problem of local infections in posterior cranial fossa and spinal surgery. The largest amount of the literature data is indeed centered on how to deal with deep infections, CSF leak, and secondary meningitis or hardware infection. Read More

    Hyperbaric oxygen therapy reduces astrogliosis and helps to recovery brain damage in hydrocephalic young rats.
    Childs Nerv Syst 2018 Jun 18;34(6):1125-1134. Epub 2018 Apr 18.
    Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo - USP, Bandeirantes Av., 3900, Ribeirão Preto, São Paulo, 14049-090, Brazil.
    Purpose: We investigated the possible beneficial effects that hyperbaric oxygen therapy could offer in different brain structures affected by ventriculomegaly in pup rats submitted to experimental hydrocephalus.

    Methods: Seven-day-old Wistar rats were submitted to hydrocephalus by intracisternal injection of 10% kaolin into the cisterna magna. The animals were divided into four groups: control (n = 5); control with HBOT (3ATA/2 h/day) (n = 5); untreated hydrocephalic (n = 10); hydrocephalic treated with HBOT (3ATA/2 h/day) (n = 10). Read More

    Pseudotumor cerebri in kaposiform lymphangiomatosis: a case report and pathogenetic hypothesis.
    Childs Nerv Syst 2018 Apr 13. Epub 2018 Apr 13.
    Regional Service of Neurosurgery, Virgen de la Arrixaca University Hospital, 30120, Murcia, Spain.
    Case Report: A 4-year-old boy with kaposiform lymphangiomatosis (KLA) developed progressive headaches and papilloedema and was diagnosed with pseudotumor cerebri initially treated with acetazolamide. Clinical deterioration prompted placement of a ventriculoperitoneal shunt. After the surgery, the child's condition has markedly improved. Read More

    Visualization of the periventricular Virchow-Robin spaces with ependymal openings.
    Childs Nerv Syst 2018 Apr 13. Epub 2018 Apr 13.
    Department of Neurological Surgery, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu, Chiba, 279-0021, Japan.
    Purpose: The morphological relationships between the periventricular Virchow-Robin spaces (VRSs) and cerebral ventricles have been poorly documented. The present study aimed to explore the issue using magnetic resonance imaging.

    Methods: A total of 211 patients were included in this study. Read More

    Peripheral nervous system maturation in preterm infants: longitudinal motor and sensory nerve conduction studies.
    Childs Nerv Syst 2018 Jun 10;34(6):1145-1152. Epub 2018 Apr 10.
    Department of Neurosciences, Psychology, Drug Research and Children's Health, University of Florence, Largo Brambilla, n°3, 50134, Florence, Italy.
    Objective: To study the evolution of sensory-motor nerves in the upper and lower limbs in neurologically healthy preterm infants and to use sensory-motor studies to compare the rate of maturation in preterm infants at term age and full-term healthy neonates.

    Methods: The study comprised 26 neurologically normal preterm infants born at 23-33 weeks of gestational age, who underwent sensory nerve conduction and motor nerve conduction studies from plantar medial and median nerves and from tibial and ulnar nerves, respectively. We repeated the same neurophysiological studies in 19 of the preterm infants every 2 weeks until postnatal term age. Read More

    Intracranial hemorrhage in term neonates.
    Childs Nerv Syst 2018 Jun 10;34(6):1135-1143. Epub 2018 Apr 10.
    Department of Radiology, Soonchunhyang University Bucheon Hospital, 170 Jomaru-ro, Wonmi-gu, Bucheon, 420-767, Republic of Korea.
    Background: Intracranial hemorrhage (ICH) is an uncommon but important cause of morbidity and mortality in term neonates; currently, ICH is more frequently diagnosed because of improved neuroimaging techniques.

    Purpose: The study aims to evaluate the clinical characteristics and neuroimaging data (pattern, size, distribution) of neonatal ICH.

    Methods: We reviewed MRI data from July 2004 to June 2015 for 42 term neonates with ICH who were less than 1 month old. Read More

    Timing of rehabilitation in children with obstetric upper trunk brachial plexus palsy.
    Childs Nerv Syst 2018 Jun 5;34(6):1153-1160. Epub 2018 Apr 5.
    Ankara Diskapi Yildirim Beyazit Training and Research Hospital, Physical Rehabilitation Medicine Clinic, Irfan Bastug Street, Altindag, Ankara, Turkey.
    Objectives: The initiation timing of rehabilitation in children with obstetric brachial plexus palsy is controversial. The aim of the present study is to evaluate the effectiveness of rehabilitation timing to the functional outcomes of patients with obstetric upper trunk brachial plexus palsy.

    Material And Methods: Twenty-nine patients, who did not previously received any rehabilitation programme but attended our outpatient clinic, were included for the study. Read More

    Intracranial malignant peripheral nerve sheath tumor variant: an unusual neurovascular phenotype sarcoma case invading through the petrous bone.
    Childs Nerv Syst 2018 Apr 3. Epub 2018 Apr 3.
    Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
    Introduction: Intracranial malignant peripheral nerve sheath tumor (MPNST) is exceedingly rare. Previously reported cases of intracranial MPNST have been associated with development within a prominent cranial nerve.

    Methods: This is the first report of an MPNST with both nerve sheath and vascular phenotype that follows the neurovascular bundle, without arising in a major cranial nerve or in the setting of neurofibromatosis type 1 (NF1). Read More

    Early analysis of operative management of Chiari I malformation in pediatric cystic fibrosis patients.
    Childs Nerv Syst 2018 Apr 2. Epub 2018 Apr 2.
    Department of Neurological Surgery, University of Texas Health San Antonio, 7703 Floyd Curl Drive MC7843, San Antonio, TX, 78229, USA.
    Introduction: Chiari I malformation, defined as herniation of the cerebellar tonsils at least 5 mm below the foramen magnum, can result from congenital or acquired pathology. While the mechanism is not well understood, an association between Chiari I and cystic fibrosis has been described in the literature. The lifelong respiratory status management necessitated by cystic fibrosis creates a greater risk of Chiari symptomatology as well as post-operative CSF-related complications in the setting of duraplasty secondary to recurrent transient increases in intracranial pressure. Read More

    Use of black-bone MRI in the diagnosis of the patients with posterior plagiocephaly.
    Childs Nerv Syst 2018 Mar 29. Epub 2018 Mar 29.
    Cleft Palate and Craniofacial Centre, Department of Plastic Surgery, Helsinki University Central Hospital, Topeliuksenkatu 3-5, PO Box 266, 00029, Helsinki, Finland.
    Purpose: Ionising radiation exposure is especially harmful to brain development. The purpose of this study was to evaluate whether black-bone (BB) magnetic resonance imaging (MRI), a non-ionising imaging method, offers an alternative to ionising imaging methods such as computed tomography (CT) in the examination of cranial deformities.

    Methods: From 2012 to 2014, a total of 408 children were referred to the Craniofacial Centre at the Helsinki University Hospital for further examination due to flatness of the posterior skull. Read More

    Traumatic brain injury in Indian children.
    Childs Nerv Syst 2018 Jun 29;34(6):1119-1123. Epub 2018 Mar 29.
    Department of Pediatrics and Department of Neuro Surgery, Aditya Birla Memorial Hospital, Pune, Maharashtra, India.
    Introduction: Traumatic brain injury (TBI) in children and adolescents is a community-based medical and educational challenge world-over due to increasing urbanization and motorization. In India, children between 1 to 15 years constitute significant proportion of the total population, who are vulnerable for TBI. In developed countries, pediatric trauma mortality still represents more than half of all childhood fatalities, which is 18 times more common than brain tumors. Read More

    Placode rotation in transitional lumbosacral lipomas: are there implications for origin and mechanism of deterioration?
    Childs Nerv Syst 2018 Mar 29. Epub 2018 Mar 29.
    Great Ormond Street Institute of Child Health, 30 Guildford Street, London, WC1N 1EH, UK.
    Purpose: Rotation of the lipoma-neural placode has been noted in transitional lumbosacral lipomas. The purpose of this study was to confirm this rotation; that this rotation occurs with a preference to the left, and correlates with clinical symptoms. In addition, this study tests the hypothesis that this rotation occurs through local mechanical forces rather than intrinsic congenital malformation. Read More

    Impact of surgery, adjuvant treatment, and other prognostic factors in the management of anaplastic ganglioglioma.
    Childs Nerv Syst 2018 Jun 29;34(6):1207-1213. Epub 2018 Mar 29.
    Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India.
    Background/purpose: Anaplastic ganglioglioma (AGG) is a rare tumor with both glial and neuronal component accounting for less than 1% of all CNS tumors with limited information about the optimum treatment and outcome of these tumors.

    Method And Materials: We did a thorough search of the PubMed with the following MesH terms: "Ganglioglioma; Anaplastic ganglioglioma; Ganglioglioma AND treatment; and Anaplastic ganglioglioma AND survival" to find all possible publications related to AGG to perform an individual patient data analysis and derive the survival outcome and optimum treatment of these tumors.

    Results: A total of 56 articles were retrieved pertaining to AGG with 88 patients. Read More

    Experience in shunt management on revision free survival in infants with myelomeningocele.
    Childs Nerv Syst 2018 Mar 26. Epub 2018 Mar 26.
    Pediatric Neurosurgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
    Objective: Depending on the etiology of hydrocephalus in childhood, the shunt therapy still remains challenging due to frequent shunt complications leading to possible revisions such as shunt infection or shunt malfunction. In myelomeningocele (MMC) patients who often require shunt therapy, higher revisions rates were reported. In a single-center retrospective study, experiences on shunt regimen on hydrocephalus associated with MMC are presented. Read More

    Management of split cord malformation in children: the Lyon experience.
    Childs Nerv Syst 2018 May 26;34(5):883-891. Epub 2018 Mar 26.
    Department of Pediatric Neurosurgery, Hôpital Femme Mère Enfant, Hospice Civil de Lyon, 59 Boulevard Pinel, 69677, Lyon Cedex, France.
    Introduction: Split cord malformation (SCM) is a rare congenital spinal abnormality. Clinical presentation varies. Other congenital defects can be associated. Read More

    Medulloblastoma, WNT-activated/SHH-activated: clinical impact of molecular analysis and histogenetic evaluation.
    Childs Nerv Syst 2018 May 26;34(5):809-815. Epub 2018 Mar 26.
    Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
    Purpose: Medulloblastoma (MDB) is a small cell poorly differentiated embryonal tumor of the cerebellum, which more frequently compromises children. Overall prognosis is favorable, but dependent of stage, histopathological pattern and molecular group. Approximately 30% of the affected patients will die from the disease. Read More

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