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    5909 results match your criteria Child's Nervous System[Journal]

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    Use of computer-assisted design and manufacturing to localize dural venous sinuses during reconstructive surgery for craniosynostosis.
    Childs Nerv Syst 2017 Sep 18. Epub 2017 Sep 18.
    Division of Pediatric Neurosurgery, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Phipps 560A, Baltimore, MD, 21287, USA.
    Objective: Cranial vault remodeling surgery for craniosynostosis carries the potential risk of dural venous sinus injury given the extensive bony exposure. Identification of the dural venous sinuses can be challenging in patients with craniosynostosis given the lack of accurate surface-localizing landmarks. Computer-aided design and manufacturing (CAD/CAM) has allowed surgeons to pre-operatively plan these complex procedures in an effort to increase reconstructive efficiency. Read More

    Deep brain stimulation for refractory temporal lobe epilepsy: a systematic review and meta-analysis with an emphasis on alleviation of seizure frequency outcome.
    Childs Nerv Syst 2017 Sep 18. Epub 2017 Sep 18.
    Department of Functional Neurosurgery, Renji hospital, Shanghai Jiao Tong university ,school of medicine, Pujian Road 160, Shanghai, China.
    Objective: Conflicting conclusions have been reported regarding predictors of deep brain stimulation (DBS) outcome in patients with refractory temporal lobe epilepsy (TLE). The main goal of this meta-analysis study was to identify possible predictors of remarkable seizure reduction (RSR).

    Methods: We conducted a comprehensive search of English-language literature published since 1990 and indexed in PubMed, Embase, and the Cochrane Library that addressed seizure outcomes in patients who underwent DBS for refractory TLE. Read More

    Child dermoid cyst mimicking a craniopharyngioma: the benefit of MRI T2-weighted diffusion sequence.
    Childs Nerv Syst 2017 Sep 18. Epub 2017 Sep 18.
    Department of Pediatric Neurosurgery, Necker Hospital, Université René Descartes, Paris Cité Sorbonne, Paris, France.
    Background: Brain dermoid cysts are very rare lesions. Although benign, these cysts may be associated with devastating complications due to mass effect or meningitis. The discovery of completely asymptomatic dermoid cysts in the pediatric population is exceedingly rare. Read More

    Penetrating orbital trauma leading to trans-orbital brain herniation.
    Childs Nerv Syst 2017 Sep 16. Epub 2017 Sep 16.
    Department of Neurosurgery, Shatabdi Hospital Phase 2, King George Medical University, Lucknow, Uttar Pradesh, 226003, India.
    Introduction: Development of a posttraumatic herniation of brain parenchyma through the orbit is a rare complication of orbital roof fracture. Mostly, the injury is due to a direct impact to the frontal region resulting in orbital roof fracture with dural defect and herniation of cerebrospinal fluid or brain parenchyma. These patients present with acute or gradually progressive proptosis with impending risk of loss of vision and mandate surgical decompression of optic nerve with watertight closure of the dural defect. Read More

    Congenital lumbar kyphosis with skin ulceration and osteomyelitis in a myelomeningocele child: a case report.
    Childs Nerv Syst 2017 Sep 16. Epub 2017 Sep 16.
    Department of Paediatric Orthopedic Surgery, Hospital Couple Enfants, Grenoble Alpes University, BP 217, 38043, Grenoble Cedex 9, France.
    Introduction: Kyphosis is a frequent problem in children with spina bifida, and this deformity may cause different complications as respiratory insufficiency, bowel dysfunction, and skin ulcers.

    Case Report: We report on a 13-year-old myelomeningocele male with a lumbar kyphoscoliosis associated to a septic skin ulceration that resulted in an acute sepsis. An X-ray revealed a kyphosis of 110° and a scoliosis of 25° between T9 and L5. Read More

    Brainstem herniation into the internal acoustic canal secondary to hydrocephalus in context of spontaneous cerebrospinal fluid otorrhea: report of a novel entity.
    Childs Nerv Syst 2017 Sep 13. Epub 2017 Sep 13.
    Department of Otolaryngology, George Washington University, 2150 Pennsylvania Ave. NW, Washington, DC, 20037, USA.
    Introduction And Clinical Presentation: The authors report a case of a 5-year-old boy presenting with vision loss, right-sided hearing loss, and facial paralysis secondary to hydrocephalus causing brainstem herniation into the internal auditory canal (IAC) following cerebrospinal fluid (CSF) otorrhea.

    Management And Outcome: After placement of a ventriculo-peritoneal shunt (VP shunt), the vision and facial palsy improved whilst hearing loss persisted. Imaging demonstrated partial reduction of the herniated brainstem and resolution of hydrocephalus. Read More

    Cyclical vomiting syndrome secondary to a Chiari I malformation-a case report.
    Childs Nerv Syst 2017 Sep 11. Epub 2017 Sep 11.
    Department of Neurosurgery, Sheffield Children's Hospital NHS Foundation Trust, Sheffield, UK.
    Background: Cyclical vomiting syndrome is a disorder characterised by recurrent episodes of profuse vomiting. There are no cases in the literature on the management of children with presenting with cyclical vomiting syndrome and a Chiari malformation type I.

    Discussion: We report the case of a 12-year-old child diagnosed with cyclical vomiting syndrome and a Chiari malformation type I. Read More

    Benign extracerebral fluid collection complicated by subdural hematoma and fluid collection: clinical characteristics and management.
    Childs Nerv Syst 2017 Sep 9. Epub 2017 Sep 9.
    Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
    Introduction: Benign extracerebral fluid collection (bECFC) can be complicated by subdural hematoma (SDH) or subdural fluid collection (SDFC). The etiology, natural history, and management strategy for SDH/SDFC in bECFC are not fully understood. We retrospectively reviewed the cases of bECFC patients complicated with SDH/SDFC and tried (1) to confirm the fact that bECFC children are vulnerable to SDH/SDFC, (2) to investigate the clinical significance of 'trauma history' witnessed by a caregiver, and (3) to determine optimal management for them. Read More

    Infant brachial neuritis following a viral prodrome: a case in a 6-month old child and review of the literature.
    Childs Nerv Syst 2017 Sep 7. Epub 2017 Sep 7.
    Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
    Introduction: Brachial neuritis, commonly known as Parsonage-Turner syndrome, affects two to three people per 100,000 and presents with pain and weakness of the arm and shoulder. Brachial neuritis is uncommon in infants.

    Methods: Here, we present the case of a 6-month old female, who presented with right upper extremity weakness and paresis following a viral prodrome. Read More

    Time-to-event analysis of surgically treated posthemorrhagic hydrocephalus in preterm infants: a single-institution retrospective study.
    Childs Nerv Syst 2017 Sep 7. Epub 2017 Sep 7.
    Department of Neurological Surgery, Washington University School of Medicine, St. Louis Children's Hospital, One Children's Place, Suite 4S20, St. Louis, MO, 63110, USA.
    Purpose: The purpose of this study is to report time points relevant to the neurosurgical management of posthemorrhagic hydrocephalus (PHH).

    Methods: Data were collected retrospectively on 104 preterm infants with intraventricular hemorrhage (IVH) who received neurosurgical intervention for PHH at St. Louis Children's Hospital from 1994 to 2016. Read More

    Lacosamide treatment of childhood refractory focal epilepsy: the first reported side effect in paediatric patients.
    Childs Nerv Syst 2017 Sep 7. Epub 2017 Sep 7.
    Istanbul Faculty of Medicine, Division of Pediatric Neurology, Department of Pediatrics, Istanbul University, Millet cd. Fatih, 34093, Istanbul, Turkey.
    Purpose: Lacosamide (LCM) is an effective antiepileptic drug (AED) approved for the treatment of focal epilepsy in both children and adults. The aim of this observational study was to review our centre's experience with LCM and to characterise its efficacy and tolerability as an adjunct therapy in children with refractory focal epilepsy.

    Methods: We retrospectively reviewed the medical records of 12 paediatric patients who underwent treatment with LCM from January 2014 to December 2015. Read More

    Dynamic morphological changes of thrombosed lateral sinus pericranii revealed by serial magnetic resonance images.
    Childs Nerv Syst 2017 Sep 6. Epub 2017 Sep 6.
    Department of Radiology, Fukuoka Children's Hospital, 5-1-1 Kashii-Teriha, Higashi-ku, Fukuoka, 813-0017, Japan.
    Background: Sinus pericranii (SP) is a rare venous anomaly involving an abnormal connection of the intracranial dural sinuses with the extracranial veins. Magnetic resonance (MR) imaging (MRI) with MR venography can detect the typically congested intra- and extracranial venous components of SP.

    Clinical Presentation: We report a rare case of lateral SP associated with the superior sagittal sinus, which might had already developed almost total thrombosis of the SP at the first MRI. Read More

    Does shape affect function? Articulatory skills in babbling of infants with deformational plagiocephaly.
    Childs Nerv Syst 2017 Sep 5. Epub 2017 Sep 5.
    Department of Orthodontics, Center for Prespeech Development & Developmental Disorders, University Hospital Würzburg, 97070, Wurzburg, Germany.
    Purpose: The purpose of this study was to quantitatively analyse pre-speech/early language skills in healthy full-term infants with moderate or severe deformational plagiocephaly (DP) and in infants without any skull asymmetry.

    Methods: At 6 and 12 months, 51 children with DP (41 moderate, 10 severe cases) were studied, along with 15 infants serving as control. Deformational plagiocephaly (DP) was objectively determined based on cranial vault asymmetry (CVA) using 3D stereophotogrammetry (3dMDhead System® and Analytics 4. Read More

    Clinical outcomes and radiosurgical considerations for pediatric arteriovenous malformation: influence of clinical features on obliteration rate.
    Childs Nerv Syst 2017 Sep 4. Epub 2017 Sep 4.
    Department of Neurosurgery, Department of Medicine, Graduate School, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-702, South Korea.
    Purpose: Gamma knife radiosurgery (GKRS) is an established treatment modality for brain arteriovenous malformation (AVM), but there have been few published studies examining the relationship between clinical features of AVM and successful obliteration with GKRS in pediatric patients. In the current study, we investigate the outcomes of GKRS for pediatric patients with brain AVM and analyze the variables that influence obliteration.

    Methods: We analyzed 68 pediatric patients (≤ 18 years) with a mean follow-up period of 61. Read More

    Infected multilocular hydrocephalus treated by rigid and flexible endoscopes with electromagnetic-guided neuronavigation: a case report.
    Childs Nerv Syst 2017 Sep 4. Epub 2017 Sep 4.
    Department of Neurosurgery, Shizuoka Children's Hospital, 860 Urushiyama, Aoiku, Shizuoka, 420-8660, Japan.
    Background: Endoscopic surgery assisted by a navigation system has greatly aided treatment of infected multilocular hydrocephalus, especially in children.

    Case Report: We describe a 2-year-old boy with multilocular hydrocephalus caused by repeated shunt infection, presenting with fever and vomiting. Magnetic resonance images (MRI) showed extraventricular cysts and severe ventricular deformity. Read More

    The impact of the introduction of PECARN head CT rules on the utilisation of head CT scans in a private tertiary hospital in Sub-Saharan Africa.
    Childs Nerv Syst 2017 Aug 30. Epub 2017 Aug 30.
    Department of Surgery, The Aga Khan University Hospital, P.O BOX 30270-00100, Nairobi, Kenya.
    Background: The decision to order head CT scans to rule out clinically significant traumatic brain injury in mild head injury in children is made on the basis of clinical decision rules of which the Paediatric Emergency Care Applied Research Network (PECARN) CT head rules have been found to be most sensitive.

    Purposes: The purpose of this study is to determine the proportion of head CT scans done for children with mild head injury and to determine disposition of patients from casualty after the introduction of PECARN head CT rules compared to the period before. The research question is "will introduction of the PECARN CT head rules reduce the proportion of head CT scans requested for children under 18 years with mild head injury at the AKUHN?"

    Methods: A before and after quasi experimental study with a study population including all children under 18 years presenting to the AKUHN with mild head injury and a Glasgow coma scale of 14 and above on presentation. Read More

    Predicting symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage with an artificial neural network in a pediatric population.
    Childs Nerv Syst 2017 Aug 29. Epub 2017 Aug 29.
    Division of Neurosurgery, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.
    Purpose: Artificial neural networks (ANN) are increasingly applied to complex medical problem solving algorithms because their outcome prediction performance is superior to existing multiple regression models. ANN can successfully identify symptomatic cerebral vasospasm (SCV) in adults presenting after aneurysmal subarachnoid hemorrhage (aSAH). Although SCV is unusual in children with aSAH, the clinical consequences are severe. Read More

    Optical coherence tomography as a marker of vision in children with optic pathway gliomas.
    Childs Nerv Syst 2017 Aug 26. Epub 2017 Aug 26.
    Department of Neurosurgery, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
    Purpose: Optic pathway gliomas (OPG) represent an important cause of visual loss in pediatric population. The indication of treatment is based on clinical or neuroimaging progression. Visual acuity loss is the most important symptom of disease progression, but children with OPG are frequently unable to complete the testing of visual function. Read More

    Measuring upper limb function in children with hemiparesis with 3D inertial sensors.
    Childs Nerv Syst 2017 Aug 25. Epub 2017 Aug 25.
    Laboratory of Movement Analysis and Measurement, Ecole Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland.
    Purpose: Upper limb assessments in children with hemiparesis rely on clinical measurements, which despite standardization are prone to error. Recently, 3D movement analysis using optoelectronic setups has been used to measure upper limb movement, but generalization is hindered by time and cost. Body worn inertial sensors may provide a simple, cost-effective alternative. Read More

    Intramedullary placement of ventricular shunts: a review of using bone as a distal cerebrospinal absorption site in treating hydrocephalus.
    Childs Nerv Syst 2017 Aug 23. Epub 2017 Aug 23.
    Seattle Science Foundation, 550 17th Avenue, Suite 600, Seattle, WA, 98122, USA.
    Purpose: Intraosseous (IO) vascular access has been used since the Second World War and is warranted when there is an emergency and/or urgent need to replenish the vascular pool. Despite long-term and satisfactory results from delivering large quantities of intravenous fluid via the medullary space of bone, use of this space for a distant receptacle for cerebrospinal fluid (CSF) diversion has seldom been considered.

    Methods: The current paper reviews the literature regarding the bony medullary space as a receptacle for intravenous fluid and CSF. Read More

    Age-related T2 relaxation times at 3 Tesla as a biomarker of infratentorial brain maturation.
    Childs Nerv Syst 2017 Aug 18. Epub 2017 Aug 18.
    Institute of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.
    Purpose: The purpose of this study was to examine age-related, infratentorial changes in T2 relaxation times during infancy and childhood using routine MRI data at 3 Tesla.

    Methods: One hundred patients (0-199 months) without signal abnormalities on conventional MRI were retrospectively selected from our pool of pediatric MRI examinations. T2 maps based on our routinely acquired triple-echo turbo spin-echo (TSE) sequence were created. Read More

    Expression of microRNAs in tumors of the central nervous system in pediatric patients in México.
    Childs Nerv Syst 2017 Aug 16. Epub 2017 Aug 16.
    Facultad de Ciencia y Tecnología, Universidad Simón Bolívar, Ciudad de México, México.
    Purpose: MicroRNAs were identified as molecules that participate in gene regulation; alterations in their expression characterize central nervous system (CNS). Information in pediatrics is scarce, so the objective of this work was to determine and then compare the patterns of expression of microRNAs in astrocytomas, ependymomas, and medulloblastomas, as well as in non-neoplastic brain.

    Methods: Low-density arrays were utilized to evaluate 756 microRNAs in three samples of each type of tumor and non-neoplastic brain. Read More

    Intradural lumbosacral malignant extrarenal rhabdoid tumor: a case report.
    Childs Nerv Syst 2017 Aug 16. Epub 2017 Aug 16.
    Department of Neurosurgery, Wayne State University, 4201 St. Antoine blvd, Suite 6E, Neurosurgery, Detroit, MI, 48201, USA.
    Background: Rhabdoid tumors are highly malignant tumors predominantly affecting the pediatric population. When these tumors occur outside of the kidneys, they are referred to as malignant extrarenal rhabdoid tumors (MERT), a rare highly aggressive subtype. Less commonly, these tumors involve the neuro-axis. Read More

    Elimination of medically intractable epileptic drop attacks following endoscopic total corpus callosotomy in Rett syndrome.
    Childs Nerv Syst 2017 Aug 16. Epub 2017 Aug 16.
    Division of Neurology, Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI, 48201, USA.
    Introduction: Rett syndrome is a neurodevelopmental genetic disorder, characterized by developmental delay, hand stereotypies, abnormal gait, and acquired microcephaly. Epilepsy is very common in Rett syndrome and can be medically intractable. It remains uncertain if a patient with epileptic drop attacks associated with this genetic disease can benefit from corpus callosotomy. Read More

    Next generation of ventricular catheters for hydrocephalus based on parametric designs.
    Childs Nerv Syst 2017 Aug 15. Epub 2017 Aug 15.
    Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MI, USA.
    Background: The flow pattern of the cerebrospinal fluid is probably the most important factor related to obstruction of ventricular catheters during the normal treatment of hydrocephalus. To better comprehend the flow pattern, we have carried out a parametric study via numerical models of ventricular catheters. In previous studies, the flow was studied under steady and, recently, in pulsatile boundary conditions by means of computational fluid dynamics (CFD) in three-dimensional catheter models. Read More

    Targeted treatment in severe traumatic brain injury in the age of precision medicine.
    Childs Nerv Syst 2017 Aug 14. Epub 2017 Aug 14.
    Division of Neurosurgery and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
    In recent years, much progress has been made in our understanding of traumatic brain injury (TBI). Clinical outcomes have progressively improved, but evidence-based guidelines for how we manage patients remain surprisingly weak. The problem is that the many interventions and strategies that have been investigated in randomized controlled trials have all disappointed. Read More

    Malignant transformation of a conservatively managed incidental childhood cerebral mass lesion: controversy regarding management paradigm.
    Childs Nerv Syst 2017 Aug 14. Epub 2017 Aug 14.
    Departments of Neurosurgery and Pediatric Neurosurgery, Tel Aviv Medical Center & Dana Children's Hospital, 6 Weizmann Street, Tel Aviv, Israel.
    Background: Incidental findings on neuroimaging in the pediatric population are an emerging treatment challenge. Treatment options for these incidental childhood brain mass lesions, which radiologically may be assumed to be low-grade gliomas (LGG), vary, ranging from careful conservative "wait and scan" treatment to surgical biopsy, gross total resection, and upfront radiation and/or chemotherapy. As malignant transformation of LGG in children is extremely rare, some series advocate careful conservative management of these lesions; however, universal treatment protocols are not totally agreed upon. Read More

    The history of optic chiasm from antiquity to the twentieth century.
    Childs Nerv Syst 2017 Aug 14. Epub 2017 Aug 14.
    Nicolae Oblu Emergency Clinical Hospital, Iasi, Romania.
    Purpose: The optic chiasm is an essential structure located at the skull base that stirred over time the curiosity of anatomists, who became more and more interested in its structure and function. Through centuries, the optic chiasm was viewed as a vessel crossing, a way of transporting tears secreted by the brain to the eye, integrating images, or responsible for coordinated eye movements. The paper aims to overview the history of understanding the optic chiasm from the beginnings of antiquity to the twentieth century. Read More

    Spontaneous complete regression of a brain stem glioma pathologically diagnosed as a high-grade glioma.
    Childs Nerv Syst 2017 Aug 14. Epub 2017 Aug 14.
    Department of Neurosurgery, Osaka Rosai Hospital, 1179-3 Nagasone-cho, Kita-ku, Sakai City, Osaka, 591-8025, Japan.
    Background: Spontaneous regressions of brain stem gliomas are extremely rare. Only six cases have been reported in the literature.

    Case Presentation: We describe the case of a patient who was diagnosed with a pontomedullary dorsal brain stem glioma at the age of 15 years. Read More

    Presentation and symptom interval in children with central nervous system tumors. A single-center experience.
    Childs Nerv Syst 2017 Aug 14. Epub 2017 Aug 14.
    Department of Pediatrics, S. Maria della Misericordia University Hospital, University of Udine, Udine, Italy.
    Purpose: The aim of this study is to describe the symptoms and signs of central nervous system (CNS) tumors in a pediatric population and to assess the time interval between the onset of the disease and the time of the diagnosis.

    Methods: A retrospective observational study was conducted at our Oncology Pediatric Unit between January 2000 and November 2011. We included 75 children between 5 months and 16 years (mean age of 7. Read More

    Association of neural tube defects with gene polymorphisms in one-carbon metabolic pathway.
    Childs Nerv Syst 2017 Aug 2. Epub 2017 Aug 2.
    Department of neurosurgery, Tianjin Children's Hospital, Beichen District, Tianjin, 300134, China.
    Purpose: Neural tube defects (NTDs) are common congenital malformations. In this study, we aimed to explore the association between single nucleotide polymorphisms (SNPs) related to one-carbon metabolism (OCM) and NTDs in Han population of Northern China.

    Methods: A case-control study was conducted in 152 children with NTDs and 169 controls. Read More

    Quality of life in long-term survivors treated for metastatic medulloblastoma with a hyperfractionated accelerated radiotherapy (HART) strategy.
    Childs Nerv Syst 2017 Aug 2. Epub 2017 Aug 2.
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G. Venezian 1, 20133, Milan, Italy.
    Purpose: An intensive therapeutic strategy for metastatic medulloblastoma was launched in 1998 in our Institution. The aim of this study was to examine the long-term quality of life (QoL) in survivor patients at least 3 years after the end of the treatment.

    Methods: Patients were asked to complete self-administered QoL questionnaires. Read More

    Neuroinfluenza: evaluation of seasonal influenza associated severe neurological complications in children (a multicenter study).
    Childs Nerv Syst 2017 Jul 31. Epub 2017 Jul 31.
    Department of Pediatric Neurology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey.
    Purpose: Although influenza primarily affects the respiratory system, in some cases, it can cause severe neurological complications. Younger children are especially at risk. Pediatric literature is limited on the diagnosis, treatment, and prognosis of influenza-related neurological complications. Read More

    Case update on cranial osteopetrosis: which is the role of the neurosurgeon?
    Childs Nerv Syst 2017 Jul 31. Epub 2017 Jul 31.
    Departement of Neuro-ophtalmology, Lille University Hospital, Lille, France.
    Purpose: Osteopetrosis (OP) is a rare skeletal disease, which can affect the skull base and calvaria. A multidisciplinary approach is mandatory and patient may need neurosurgical care. Few observations have been published, and optimal management of OP is not established yet. Read More

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