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    Role of temperature in reported chickenpox cases in northern European countries: Denmark and Finland.
    BMC Res Notes 2018 Jun 13;11(1):377. Epub 2018 Jun 13.
    Department of Hygiene, Sapporo Medical University School of Medicine, S-1, W-17, Chuo-ku, Sapporo, Hokkaido, 060-8556, Japan.
    Objective: In this study, we sought to explore the temperature-dependent transition of patterns of reported chickenpox cases in the northern European countries of Denmark and Finland to help determine the potential relationship with epidemiological factors of the disease. We performed time-series analysis consisting of a spectral analysis based on the maximum entropy method in the frequency domain and the nonlinear least squares method in the time domain, using the following time-series data: monthly data of reported chickenpox cases and mean temperatures in the pre-vaccination era for Denmark and Finland. The results were compared with those reported for China and Japan in our previous studies. Read More

    Varicella infection in the Middle East: Prevalence, complications, and vaccination.
    J Res Med Sci 2018 26;23:19. Epub 2018 Apr 26.
    Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait.
    Varicella (chickenpox) is the primary infection of varicella-zoster virus (VZV), it is a mild self-limiting infection, but it is also highly contagious and can cause severe complications among high-risk group of individuals. It is usually a childhood infection providing lifelong immunity, but adults without varicella history are also susceptible to infection. High-risk group of individuals is more likely to develop serious complications. Read More

    Childhood infectious diseases and risk of multiple myeloma: an analysis of the Italian multicentre case-control study.
    Epidemiol Infect 2018 May 30:1-3. Epub 2018 May 30.
    Cancer Epidemiology Unit,Imperial College,London,UK.
    Common childhood infectious diseases have been associated with a reduced risk of following haematopoietic malignancies, but investigations on multiple myeloma (MM) are scarce. Information about 213 MM cases and 1128 healthy controls were obtained from a multicentre population-based Italian case-control study. The association between chickenpox, measles, mumps, pertussis and rubella and the MM risk was estimated by unconditional logistic regression, adjusting for age, gender and residence area. Read More

    Participatory capacity building for improving quality of childcare centers in Thailand.
    Rural Remote Health 2018 May 28;18(2):4570. Epub 2018 May 28.
    Gillings School of Global Public Health, Public Health Leadership Program and Department of Maternal and Child Health, 4107 McGavran-Greenberg Hall, CB #7469 135 Dauer Drive, Chapel Hill, NC 27599, USA
    Introduction: Childcare centers (CCCs) with good quality standards can be effective in reducing the risk of diseases being easily spread from person to person. The aim of the present study's program, adapted from a method used by the United Nations Development Program, was to increase the capacity of local administrators(s) and heads of CCCs to improve quality standards.

    Methods: This study was quasi-experimental, with a one group pretest-post-test design. Read More

    Management of chickenpox in pregnant women: an Italian perspective.
    Eur J Clin Microbiol Infect Dis 2018 May 25. Epub 2018 May 25.
    Department of Clinical Medicine and Surgery- Section of Infectious Diseases, University Federico II of Naples, Naples, Italy.
    Chickenpox is a highly contagious disease caused by primary infection of varicella zoster virus (VZV). The disease is spread worldwide and is usually benign but, in some groups of population like pregnant women, can have a severe outcome. Due to a not optimal vaccination coverage, a relatively high number of childbearing-aged women in a European country such as Italy tested seronegative for VZV and so are currently at risk of acquiring chickenpox during pregnancy, especially if they live in contact with children for family or work reasons. Read More

    Chickenpox: An update.
    Med Mal Infect 2018 May 19. Epub 2018 May 19.
    Assistance publique-Hôpitaux de Marseille (AP-HM), pharmacie usage intérieur, hôpital de la conception, 147, boulevard Baille, 13005 Marseille, France; Laboratoire de pharmaco-chimie radicalaire, faculté de pharmacie, Aix-Marseille Université, CNRS, ICR, UMR 7273, 27, boulevard Jean-Moulin-CS30064, 13385 Marseille cedex 05, France. Electronic address:
    Despite its benign characteristics, chickenpox is a childhood disease responsible for complications and deaths, particularly in the high-risk population. VariZIG, not commercialized in France, is a good alternative for seronegative individuals exposed to the virus and not eligible for vaccination. The efficacy of routine vaccination has been demonstrated with a decrease in chickenpox incidence and with the development of herd immunity. Read More

    Genetic epidemiology and risk factors for brain tumors.
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Apr;43(4):345-353
    Department of Medicine, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston TX 77030, USA.
    This report summarized current knowledge and findings relevant to environmental and genetic risk factors in brain tumors, with a particular focus on glioma. To date, the established risk factors for brain tumors are family history and ionizing radiation exposure; whereas there is an inverse association between tumors and other factors such as history of allergies, atopic conditions, chickenpox, and varicella zoster virus infection. To identify inherited genetic variants impacting susceptibility of brain tumors, large scale familial linkage-scan pedigree analysis, population-based candidate genes, and genome-wide association study were performed. Read More

    Effectiveness And Impact Of A Single-Dose Vaccine Against Chickenpox In The Community Of Madrid Between 2001 And 2015.
    Hum Vaccin Immunother 2018 May 17:1-19. Epub 2018 May 17.
    a Health Department of the Community of Madrid , Subdirectorate of Epidemiology , Madrid , Spain.
    Background: Chickenpox is a contagious airborne disease. Immunization by varicella vaccine is an effective preventive measure. The objective of this study is to evaluate the impact and effectiveness of a single-dose vaccination against chickenpox at 15 months of age. Read More

    Epidemiology, management and outcome of varicella in pregnancy: a 20-year experience at the Tuscany Reference Centre for Infectious Diseases in Pregnancy.
    Infection 2018 May 15. Epub 2018 May 15.
    SOD Malattie Infettive e Tropicali, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla 3, 50134, Florence, Italy.
    Data from 215 pregnant women exposed to varicella and 276 with varicella observed at the Tuscany Reference Center for Infectious Diseases in Pregnancy, Florence, Italy, in the period 1997-2016 were retrospectively collected. The risk of developing varicella was lower in exposed women who received varicella zoster immunoglobulin compared with those who did not receive it [42% (21 of 50) vs 72% (13 of 18); p = 0.0263]. Read More

    Unusual cause of brachial palsy with diaphragmatic palsy.
    BMJ Case Rep 2018 May 12;2018. Epub 2018 May 12.
    Vidant Medical Center, East Carolina University, Greenville, North Carolina, USA.
    We report a preterm neonate born with respiratory distress. The neonate was found to have diaphragmatic palsy and brachial palsy. The neonate was born by caesarean section and there was no history of birth trauma. Read More

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    J Virol 2018 May 9. Epub 2018 May 9.
    Merck Research Laboratories, Department of Infectious Diseases and Vaccines, Merck & Co., Inc., Kenilworth, NJ, USA
    Herpes zoster (HZ/shingles) is the clinical manifestation of varicella zoster virus (VZV) reactivation. HZ typically develops as people age due to decreased cell-mediated immunity. However, the importance of antibodies for immunity against HZ prevention remains to be understood. Read More

    Early Treatment Was Life Saving in Varicella Pneumonia of an Immunocompetent Adult.
    Arch Iran Med 2018 May 1;21(5):223-225. Epub 2018 May 1.
    Infectious Disease and Clinical Microbiology, Erzurum Region Training and Research Hospital, Erzurum, Turkey.
    Chickenpox, an infection of childhood with vesicular skin rash, is caused by varicella-zoster virus (VZV). Although the infection is rare in adults, it can cause serious complications Varicella pneumonia is the most encountered complication. In this report, a VZV pneumonia case in a previously healthy adult is presented. Read More

    Varicella Zoster Virus Infection and Osteomyelitis of the Skull: A Case Report.
    World Neurosurg 2018 May 4. Epub 2018 May 4.
    Department of Neurosurgery, University of Utah, Salt Lake City, Utah. Electronic address:
    Background: Varicella zoster virus (VZV) is a common herpesvirus infection that can result in acute varicella/chickenpox as well as delayed activation in herpes zoster/shingles. Ramsay-Hunt syndrome is a rare presentation of VZV reactivation, involving 1% of cases and resulting in lesion formation along the 7 cranial nerve distribution. We report the first case of a patient who presented with acute calvarial osteomyelitis after VZV reactivation and Propionibacterium acnes suprainfection. Read More

    PEPtalk2: results of a pilot randomised controlled trial to compare VZIG and aciclovir as postexposure prophylaxis (PEP) against chickenpox in children with cancer.
    Arch Dis Child 2018 May 5. Epub 2018 May 5.
    Paediatric Infectious Diseases Research Group and Vaccine Institute, Institute of Infection and Immunity, St. Georges, University of London, London, UK.
    Objective: To determine the likely rate of patient randomisation and to facilitate sample size calculation for a full-scale phase III trial of varicella zoster immunoglobulin (VZIG) and aciclovir as postexposure prophylaxis against chickenpox in children with cancer.

    Design: Multicentre pilot randomised controlled trial of VZIG and oral aciclovir.

    Setting: England, UK. Read More

    Varicella Pneumonia: Case Report and Review of a Potentially Lethal Complication of a Common Disease.
    J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618770230. Epub 2018 Apr 18.
    Rutgers University, New Brunswick, NJ, USA.
    Varicella zoster virus causes varicella (chickenpox). It can be reactivated endogenously many years later to cause herpes zoster (shingles). Although varicella is usually a benign disease in healthy children, it resulted in over 11 000 hospitalizations and over 100 deaths every year, in all ages, in the United States. Read More

    The Skin and the Eye - Herpes Zoster Ophthalmicus in a Healthy 18-month-old Toddler.
    Folia Med (Plovdiv) 2018 Mar;60(1):170-174
    Department of Ophthalmology, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria.
    Herpes zoster, caused by reactivation of varicella-zoster virus, is uncommon in infancy. Even more uncommon is herpes zoster ophthalmicus, defined as herpes zoster of the ophthalmic branch of the fifth cranial nerve. Among healthy children, primary varicella-zoster virus infection during gestation as a result of maternal varicella or the first year of life is the major risk factor for development of herpes zoster in a relatively young age. Read More

    Severe Varicella Pneumonia in Adults: Seven Years' Single-center Experience from India.
    Indian J Crit Care Med 2018 Mar;22(3):162-167
    Department of Community Medicine, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
    Context: Varicella pneumonia is a rare but a serious complication of chickenpox in adults. There is paucity of data on varicella pneumonia from India.

    Aims: The aim of this study is to describe the clinical manifestations, hospital course, treatment, and outcome of adult patients with severe varicella pneumonia. Read More

    Is varicella vaccination associated with pediatric arterial ischemic stroke? A population-based cohort study.
    Vaccine 2018 05 11;36(20):2764-2767. Epub 2018 Apr 11.
    University of Calgary, Cumming School of Medicine, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada; Analytics and Performance Reporting, Alberta Health, P.O. Box 1360, Station Main, Edmonton, AB T5J 2N3, Canada; School of Public Health, University of Alberta, 3-300 Edmonton Clinic Health Academy, 11405- 87 Ave, Edmonton, Alberta T6G 1C9, Canada; Division of Preventive Medicine, Faculty of Medicine and Dentistry, University of Alberta, 13-103 Clinical Sciences Building, 11350-83 Avenue, Edmonton, Alberta T6G 2G3, Canada.
    Background And Purpose: Varicella disease is a risk factor for pediatric Arterial Ischemic Stroke (AIS). Isolated case reports have emerged suggesting that varicella vaccination may also pose a risk for AIS.

    Methods: This retrospective population-based cohort study assessed the risk of AIS in children who received a varicella-containing vaccine, as compared to those who did not. Read More

    Elderly-onset varicella pneumonia in a patient with rheumatoid arthritis taking tofacitinib.
    Arthritis Rheumatol 2018 Apr 12. Epub 2018 Apr 12.
    Department of Internal Medicine, Tomakomai City General Hospital, Tomakomai, Japan.
    A 68-year-old woman with rheumatoid arthritis, who was treated with tofacitinib, a type of Janus kinase (JAK) inhibitor, was admitted for dyspnea and generalized purpuric vesicular rash, following 3 days of fever and malaise. She developed hypoxia from respiratory insufficiency. On physical examination, the systemic eruptions had an erythematous base and were present in various stages, from maculopapular to vesicular and pustular, with crusting (left). Read More

    Granulysin as a novel factor for the prognosis of the clinical course of chickenpox.
    Epidemiol Infect 2018 May 10;146(7):854-857. Epub 2018 Apr 10.
    Burch University Sarajevo,Bosnia-Herzegovina.
    Granulysin is a recently discovered cytolytic protein of natural killer (NK) cells and cytotoxic T lymphocytes. Studies of healthy and immunocompromised patients with primary or recurrent varicella-zoster infections demonstrate the importance of virus-specific cellular immunity in controlling viral replication, but also some studies presented granulysin as a molecule that can play a role in chickenpox immunopathogenesis. This study investigated possible correlation between serum granulysin levels and clinical course of chickenpox. Read More

    Classic paper: Are the chickenpox virus and the zoster virus identical?: HELMUT RUSKA.
    Rev Med Virol 2018 May 6;28(3):e1975. Epub 2018 Apr 6.
    Institute of Virology, University of Ulm Medical School, Ulm, Germany.
    As early as 1943, the German physician Helmut Ruska visualized the virus of varicella and zoster (at that time, he was not completely certain whether the virus was the same) by the newly developed electron microscope; he is regarded as the discoverer of this virus. Here, we present a translation of his classical paper into the English language. In our introduction and commentary to his paper, we discuss the significance of Helmut Ruska's work for the development of virology, his distinction between the varicella, zoster, and herpes virus group on one hand and poxviruses on the other, as well as the development of imaging techniques which have refined or substituted for electron microscopy of viruses and virus-infected cells. Read More

    Varicella-zoster virus necrotising retinitis, retinal vasculitis and panuveitis following uncomplicated chickenpox in an immunocompetent child.
    BMJ Case Rep 2018 Apr 5;2018. Epub 2018 Apr 5.
    Manchester Royal Eye Hospital, Manchester, UK.
    A 4-year-old girl presented with acute left visual loss 4 weeks after uneventful chickenpox. She was found to have left necrotising retinitis and profound retinal vasculitis and vitritis. Aqueous humour was PCR positive for varicella-zoster virus. Read More

    Maritime varicella illness and death reporting, U.S., 2010-2015.
    Travel Med Infect Dis 2018 May - Jun;23:27-33. Epub 2018 Apr 3.
    Division of Global Migration and Quarantine (DGMQ), Centers for Disease Control and Prevention (CDC), 1600 Clifton Road NE, Atlanta, GA 30329-4018, United States. Electronic address:
    Background: Ships destined for, or departing from, U.S. ports of entry must report certain signs and symptoms of potentially communicable diseases of public health interest among travelers to the Division of Global Migration and Quarantine (DGMQ) at the Centers for Disease Control and Prevention. Read More

    Vernet syndrome resulting from varicella zoster virus infection-a very rare clinical presentation of a common viral infection.
    J Neurovirol 2018 Jun 12;24(3):379-381. Epub 2018 Mar 12.
    Neurology, Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar de Lisboa Norte, Av. Prof. Egas Moniz, 1649-035, Lisbon, Portugal.
    Vernet syndrome is a unilateral palsy of glossopharyngeal, vagus, and accessory nerves. Varicella zoster virus (VZV) infection has rarely been described as a possible cause. A 76-year-old man presented with 1-week-long symptoms of dysphonia, dysphagia, and weakness of the right shoulder elevation, accompanied by a mild right temporal parietal headache with radiation to the ipsilateral ear. Read More

    Infections in Children: Report of Two Cases.
    Case Rep Pediatr 2018 21;2018:4158734. Epub 2018 Jan 21.
    Department of Microbiology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal.
    Introduction: primarily an environmental and agricultural organism has been reported as both commensal and pathogen of humans. We present two case reports of infections in children that involved the meninges and bloodstream.

    Case Presentations: A 6-month-old female baby, diagnosed as congenital hydrocephalus secondary to aqueduct stenosis with ventriculoperitoneal shunt in situ, operated 14 days back was brought to the pediatric emergency with a two-day history of high fever associated with vomiting, irritability, excessive crying, and decreased feeding. Read More

    The changing epidemiology of varicella and herpes zoster in Hong Kong before universal varicella vaccination in 2014.
    Epidemiol Infect 2018 Apr 12;146(6):723-734. Epub 2018 Mar 12.
    Department of Infectious Disease Epidemiology,Faculty of Epidemiology and Population Health,London School of Hygiene and Tropical Medicine,London,UK.
    In Hong Kong, universal varicella vaccination started in July 2014. Before this, children could receive varicella vaccine via the private market. We analysed the epidemiology of varicella and zoster before universal vaccination. Read More

    Incidence and mortality rates of varicella among end stage renal disease (ESRD) patients in Singapore General Hospital, a 12-year review.
    BMC Infect Dis 2018 03 7;18(1):118. Epub 2018 Mar 7.
    Department of Family Medicine and Continuing Care, Singapore General Hospital, Singapore, Singapore.
    Background: End stage renal disease (ESRD)/ end stage renal failure (ESRF) is on the rise globally and especially in Singapore. Varicella or chickenpox is not uncommon among adults especially ESRD/ESRF patients. It has been reported to cause complications and even death among immunocompetent adults. Read More

    Impact of a vaccination programme in children vaccinated with ProQuad, and ProQuad-specific effectiveness against varicella in the Veneto region of Italy.
    BMC Infect Dis 2018 03 5;18(1):103. Epub 2018 Mar 5.
    Epidemiology, MSD, 162 avenue Jean Jaurès, Lyon, France.
    Background: Monovalent varicella vaccines have been available in the Veneto Region of Italy since 2004. In 2006, a single vaccine dose was added to the immunisation calendar for children aged 14 months. ProQuad®, a quadrivalent measles-mumps-rubella-varicella vaccine, was introduced in May 2007 and used, among other varicella vaccines, until October 2008. Read More

    [Varicella vaccination: scientific reasons for a different strategic approach].
    Epidemiol Prev 2018 Jan-Feb;42(1):65-70
    Cochrane Collaboration - revisioni sistematiche sull'efficacia e sicurezza dei vaccini.
    The Italian Parliament has recently introduced 10 mandatory immunisations, including the one against varicella. For this vaccination, the obligation starts with the birth cohort of 2017, but it is offered free of charge to subjects with a negative history and not previously vaccinated. This paper presents up-to-date evidence on this issue and illustrates a number of critical arguments that may question the opportunity of this choice. Read More

    Varicella-zoster-virus vaccination in immunosuppressed children with rheumatic diseases using a pre-vaccination check list.
    Pediatr Rheumatol Online J 2018 Mar 2;16(1):15. Epub 2018 Mar 2.
    German Center for Pediatric and Adolescent Rheumatology, Gehfeldstr. 24, 82467, Garmisch-Partenkirchen, Germany.
    Background: The goal of this study was to apply the varicella zoster virus (VZV) vaccine to patients with pediatric rheumatic diseases (PRD) at risk for severe chickenpox, without interrupting their current immunosuppression, including biological agents, using an immunological-based pre-vaccination checklist to assure safety. A pre-vaccination checklist was implemented to ensure adequate immune competence prior to immunization.

    Methods: This prospective study included seronegative patients (VZV-IgG ≤200 mIU/ml) and patients who had previously received only a single dose of VZV vaccine. Read More

    Varicella-zoster virus infection: natural history, clinical manifestations, immunity and current and future vaccination strategies.
    New Microbiol 2018 Apr 2;41(2):95-105. Epub 2018 Mar 2.
    Virology Unit, Pisa University Hospital, Pisa, Italy.
    Varicella-zoster virus (VZV) is the etiologic agent of varicella (chicken pox), a childhood exanthematic disease that develops as a result of primary infection, and zoster (shingles), caused by reactivation of the virus persisting in a latent form in the dorsal sensory ganglia. Although varicella is generally a mild self-limiting illness, in immunocompromised subjects and adults it can have a serious clinical course that can lead to permanent damage of the central nervous system. In these and in most zoster cases, treatment with anti-herpetic drugs and/or immunotherapy is necessary. Read More

    Herpes zoster ophthalmicus with associated vasculopathy causing stroke.
    Dermatol Online J 2017 Jul 15;23(7). Epub 2017 Jul 15.
    University Of Cincinnati, Department of Dermatology, Cincinnati, Ohio.
    Varicella zoster virus (VZV) is an exclusively human, double-stranded DNA virus. Primary infection causes varicella (chickenpox); later the virus becomes dormant in the dorsal root, cranial nerve, and autonomic ganglia along the entire span of the nervous system, retaining the capacity to reactivate and cause a variety of dermal and neurological complications. Recently there has been increasing recognition, both clinically and epidemiologically, of the relationship between VZV and subsequent strokes. Read More

    [Varicella and herpes zoster: challenges for public health].
    Salud Publica Mex 2017 Nov-Dec;59(6):650-656
    MSD México. Ciudad de México, México.
    Objective: To evaluate the epidemiological behavior of varicella and herpes zoster (HZ) to determine the need of health policies to diminish prevalence and avoid complications.

    Materials And Methods: To assess frequency, we analyzed data from the National Information System for Epidemiological Surveillance (SUIVE) from 2000 to 2013; to assess the discharge data of varicella and HZ, we evaluated information from the National System of health information (Sinais).

    Results: The average annual cases of chickenpox were 296 733, 57% mostly children under 9 years, most of them from March to May. Read More

    Chickenpox outbreak in a tribal and industrial zone from the Union Territory of Dadra and Nagar Haveli, India.
    Epidemiol Infect 2018 Mar 13;146(4):476-480. Epub 2018 Feb 13.
    ICMR-National Institute of Virology,20-A Dr Ambedkar Road,Pune 411001,India.
    During 9th December 2016 and 12th February 2017, 149-chickenpox cases were reported in a tribal and industrial zone of Rakholi (n = 80) and Surangi (n = 69) villages from Union Territory of India. An epidemiological investigation was performed to assess the characteristics and determinants of the chickenpox outbreak. Overall, the attack rate per 100 population in Rakholi village (n = 1757) was 4. Read More

    Herpes Zoster and Postherpetic Neuralgia: Prevention and Management.
    Am Fam Physician 2017 Nov;96(10):656-663
    Nellis Family Medicine Residency, Mike O'Callaghan Federal Medical Center, Nellis Air Force Base, NV, USA.
    Herpes zoster, or shingles, is caused by reactivation of varicella zoster virus, which causes chickenpox. There are an estimated 1 million cases in the Unites States annually, with an individual lifetime risk of 30%. Patients with conditions that decrease cell-mediated immunity are 20 to 100 times more likely to develop herpes zoster. Read More

    The impact of immunization programs on 10 vaccine preventable diseases in Italy: 1900-2015.
    Vaccine 2018 03 7;36(11):1435-1443. Epub 2018 Feb 7.
    Department of Infectious Diseases, Istituto Superiore di Sanità (Italian National Institute of Health), Rome, Italy.
    Background: Vaccination has determined a dramatic decline in morbidity and mortality from infectious diseases over the last century. However, low perceived risk of the infectious threat and increased concern about vaccines' safety led to a reduction in vaccine coverage, with increased risk of disease outbreaks.

    Methods: Annual surveillance data of nationally communicable infectious diseases in Italy between 1900 and 2015 were used to derive trends in morbidity and mortality rates before and after vaccine introduction, focusing particularly on the effect of vaccination programs. Read More

    [Hope-Simpson and shingles].
    Ned Tijdschr Geneeskd 2018 ;162(0):D2158
    Nederlands Huisartsen Genootschap, afd. Richtlijnontwikkeling en Wetenschap, Utrecht.
    Dr Robert Edgar Hope-Simpson (1908-2003) was a British general practitioner, who has laid the foundation for unravelling the pathogenesis of shingles. At the beginning of the 20th century, both conditions were known to be related, but the precise relationship was unclear. It was assumed that chickenpox could originate after infection by both a person with shingles or someone with chickenpox, but that both diseases were caused by different viruses. Read More

    Patient's experiences with the care for juvenile idiopathic arthritis across Europe.
    Pediatr Rheumatol Online J 2018 Feb 8;16(1):10. Epub 2018 Feb 8.
    Paediatric Rheumatology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Room KC.03.063.0, P.O. box 85090, 3508, AB, Utrecht, The Netherlands.
    Background: To assess the views of juvenile idiopathic arthritis (JIA) patients and their parents on the care and treatment they receive in referral pediatric rheumatology centers throughout Europe.

    Methods: In a collaboration between physicians and patient associations, a questionnaire was developed, covering various domains of JIA care, including demographics, diagnosis, referrals to various health care professionals, access to pain and fatigue management and support groups, information they received about the disease and awareness of and participation in research. The questionnaire was translated and distributed by parent associations and pediatric rheumatologists in 25 countries, 22 of which were European. Read More

    Chickenpox in Poland in 2015
    Przegl Epidemiol 2017 ;71(4):487-491
    National Institute of Public Health – National Institute of Hygiene in Warsaw, Department of Epidemiology
    Background: A large number of chickenpox cases, indicates the rationale for the use of chickenpox vaccinations. In Poland since 2002, chickenpox vaccination is included in the National Immunisation Programme as recommended.(1)

    Aim: To assess epidemiological situation of chickenpox in Poland in 2015 in comparison to previous years

    Methods: The descriptive analysis was based on based on the results of the analysis of aggregate data published in the annual bulletins “Infectious diseases and poisonings in Poland in 2015” and “Vaccinations in Poland in 2015” (2,3). Read More

    Economic burden of varicella in children 1-12 years of age in Argentina, 2009-2014.
    J Med Econ 2018 Apr 7;21(4):416-424. Epub 2018 Feb 7.
    d Merck & Co., Inc. , Kenilworth , NJ , USA.
    Background: In Argentina, varicella vaccination was included in the national schedule for mandatory immunizations in 2015. The vaccine has been shown to substantially reduce the morbidity and mortality associated with the virus. The purpose of this study was to evaluate the clinical and economic burden associated with varicella in Argentina prior to vaccine introduction. Read More

    Epidemic Varicella Zoster Virus among University Students, India.
    Emerg Infect Dis 2018 Feb;24(2):366-369
    We investigated a yearlong varicella zoster virus outbreak in a highly susceptible young adult population at a large university in India. Outbreaks of varicella infection among adults are not well described in the literature. Infection control measures and vaccination policy for this age group and setting are needed. Read More

    Attenuation of Simian Varicella Virus Infection by Enhanced Green Fluorescent Protein in Rhesus Macaques.
    J Virol 2018 04 14;92(7). Epub 2018 Mar 14.
    Division of Microbiology, Tulane University, Tulane National Primate Research Center, Covington, Louisiana, USA.
    Simian varicella virus (SVV), the primate counterpart of varicella-zoster virus, causes varicella (chickenpox), establishes latency in ganglia, and reactivates to produce zoster. We previously demonstrated that a recombinant SVV expressing enhanced green fluorescent protein (rSVV.eGFP) is slightly attenuated both in culture and in infected monkeys. Read More

    Evaluation of two health education interventions to improve the varicella vaccination: a randomized controlled trial from a province in the east China.
    BMC Public Health 2018 01 16;18(1):144. Epub 2018 Jan 16.
    Department of Expanded Program on Immunization, Zhejiang Provincial Center for Disease Control and Prevention, No. 3399 Binsheng Road, Binjiang District, Hangzhou, People's Republic of China.
    Background: We evaluated the effect of two Elaboration Likelihood Model (ELM)-based health educational interventions on varicella vaccine (VarV) vaccination among pregnant women in a province in the east China.

    Methods: A prospective randomized controlled trial was conducted among 200 pregnant women with ≥12 gestation weeks to test two interventions, including a messaging video and a messaging booklet. The participants were randomly assigned into the control group, the video group or the booklet group. Read More

    Utility of ultra-deep sequencing for detection of varicella-zoster virus antiviral resistance mutations.
    Antiviral Res 2018 Mar 12;151:20-23. Epub 2018 Jan 12.
    Persistent Viral Infections Team, U1135, CR7, CIMI-UPMC and AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, Service de Virologie, Paris, France. Electronic address:
    We report the first application of ultra-deep sequencing (UDS) to varicella-zoster virus (VZV) genotypic antiviral testing in a case of acyclovir-resistant VZV infection initially detected by Sanger sequencing within a deeply immunocompromised heart transplant recipient. As added-value compared to Sanger analysis, UDS revealed complex dynamics of viral population under antiviral pressure. Varicella-zoster virus (VZV) is a ubiquitous human herpesvirus affecting populations worldwide. Read More

    A New Combined Vaccine Against Measles, Mumps, Rubella and Varicella in India.
    Indian Pediatr 2017 12;54(12):1041-1046
    PD Hinduja National Hospital, and #GSK; Mumbai, India; and $GSK, Wavre, Belgium. Correspondence to: Dr Raunak Parikh,GSK, Dr Annie Besant Rd, 400030 Mumbai, India.
    A quadrivalent MMRV (measles-mumps-rubella-varicella) combination vaccine has recently been launched in India. This vaccine is highly immunogenic, with seroconversion rates against all antigens reaching 96.6-100% at 42 to 56 days after the second vaccine dose in unvaccinated children or in those previously vaccinated with MMR+/-V. Read More

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