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    Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox.
    Sci Rep 2017 Apr 24;7(1):1077. Epub 2017 Apr 24.
    Centre for Health Economics Research & Modeling Infectious Diseases (CHERMID), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium.
    Re-exposure to chickenpox may boost varicella-zoster virus (VZV) immunity in the elderly. This secondary immune response is hypothesized to confer protection against herpes zoster. We longitudinally sampled 36 adults over the course of one year after re-exposure to chickenpox. Read More

    [Decrease in the incidence of chickenpox in the Community of Madrid after universal childhood immunization. Years 2001-2015].
    Aten Primaria 2017 Apr 19. Epub 2017 Apr 19.
    Servicio de Epidemiología, Subdirección de Epidemiología, Dirección General de Salud Pública, Consejería de Sanidad, Comunidad de Madrid, Madrid, España.
    Objective: Varicella vaccine was recommended in the Community of Madrid (CM) at 15months of age between November 2006 and December 2013. The objective was to describe the impact of vaccination on the incidence of varicella in the CM during the period 2001-2015.

    Design: A descriptive study of cases of varicella reported to the Sentinel Physician Network of the CM and the cases recorded in the Minimum Basic Data Set at hospital discharge was carried out. Read More

    Inhibition of varicella‑zoster virus replication by an ethanol extract of Lysimachia mauritiana.
    Mol Med Rep 2017 Apr 7. Epub 2017 Apr 7.
    Department of Life Science, Gachon University, Seongnam‑Si, Kyeonggi‑Do 461‑701, Republic of Korea.
    Varicella‑zoster virus (VZV), a ubiquitous human α‑herpesvirus, is the causative agent of chickenpox and shingles. In the present study, we investigated the antiviral activity of a 70% ethanol extract of Lysimachia mauritiana (LME) against VZV. LME strongly interfered with the replication of both laboratory and clinical strains of VZV without affecting the viability of MRC‑5 cells. Read More

    Varicella zoster virus infection after allogeneic hematopoietic cell transplantation in children using a relatively short duration of acyclovir prophylaxis: A retrospective study.
    Medicine (Baltimore) 2017 Apr;96(14):e6546
    aDepartment of Pediatrics bThe Vaccine Bio Research Institute cThe Catholic Blood and Marrow Transplantation Center dDivision of Infectious Diseases, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
    Although acyclovir prophylaxis against varicella zoster virus (VZV) infection for ≥1 year is recommended after allogeneic hematopoietic cell transplantation (HCT), the emergence of acyclovir-resistant viruses and adverse drug effects cannot be ignored. We investigated the cumulative incidence of VZV infection after allogeneic HCT in children receiving a shorter duration of acyclovir prophylaxis than recommended and evaluated the appropriateness of the short duration of acyclovir prophylaxis.Medical records of 217 children who received allogeneic HCT were retrospectively reviewed until a median of 25 months (range = 1-59 months) after HCT. Read More

    Vaccination campaign at a temporary camp for victims of the earthquake in Lorca (Spain).
    Hum Vaccin Immunother 2017 Mar 31:1-8. Epub 2017 Mar 31.
    a Health Department , Vaccinations Programme , Region of Murcia , Spain.
    Outbreaks in temporary camps are an important risk for the health of the displaced population. The town of Lorca (Murcia, Spain) suffered 2 earthquakes on May 2011 that required the re-housing of 1,424 victims in a temporary camp. Following 4 cases of chickenpox control measures were adopted among the displaced population. Read More

    Varicella seroepidemiology in United States air force recruits: A retrospective cohort study comparing immunogenicity of varicella vaccination and natural infection.
    Vaccine 2017 Apr 27;35(18):2351-2357. Epub 2017 Mar 27.
    Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Building A, Room 1040A, Bethesda, MD, USA.
    Background/objectives: Infection with varicella zoster virus (VZV) produces lifelong immunity, but duration of post-vaccination immunity has not been established. The purpose of this study is to determine if a difference exists in the long-term seropositivity of anti-VZV antibodies in a cohort of young adults who were vaccinated against varicella as compared to a similar cohort with a history of chickenpox disease, and to determine which variables best predict waning seropositivity following varicella vaccination.

    Methods: This retrospective cohort study captures immunization and serology data from approximately 10,000 recruits who entered basic military training between January 1, 2008, and December 31, 2015, and who have childhood immunization records in the Air Force Aeromedical Services Information Management System. Read More

    ORF7 of Varicella-Zoster Virus Is Required for Viral Cytoplasmic Envelopment in Differentiated Neuronal Cells.
    J Virol 2017 Mar 29. Epub 2017 Mar 29.
    State Key Laboratory of Virology, CAS Center for Excellence in Brain Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
    Although a varicella-zoster virus (VZV) vaccine has been used for many years, the neuropathy caused by VZV infection is still a major health concern. ORF7 of VZV has been recognized as a neurotropic gene in vivo, but its neurovirulent role remains unclear. In the present study, we investigated the effect of ORF7 deletion on VZV replication cycle at virus entry, genome replication, gene expression, capsid assembly and cytoplasmic envelopment, and transcellular transmission in differentiated neural progenitor cells (dNPCs) and neuroblastoma SH-SY5Y (dSY5Y) cells. Read More

    Epidemiology of varicella in Haidian district, Beijing, China-2007-2015.
    Vaccine 2017 Apr 23;35(18):2365-2371. Epub 2017 Mar 23.
    Beijing Haidian District Center for Diseases Control and Prevention, People's Republic of China.
    Background: 1-Dose varicella vaccination was recommended for children in Beijing before November 2012. To further control school-based outbreaks and decrease incidence, a 2-dose vaccination was implemented in 2013. We described the varicella epidemiology and assessed impact of the 2-dose vaccination in Haidian district, Beijing, 2007-2015. Read More

    Localization of VZV in saliva of zoster patients.
    J Med Virol 2017 Mar 11. Epub 2017 Mar 11.
    NASA- Johnson Space Center, Houston TX, 77058.
    Varicella zoster virus (VZV) in saliva from 6 herpes zoster patients and 1 chickenpox patient was found to be exclusively associated with epithelial cells by confocal microscopy. VZV localization with antibody specific to the VZV glycoprotein E was detected primarily on the membrane but was also inside the cell. Epithelial cells with VZV were still present in saliva in 1 out of two tested zoster patients after 10 months of recovery. Read More

    Paediatric Active Enhanced Disease Surveillance inaugural annual report, 2014.
    Commun Dis Intell Q Rep 2016 Sep 30;40(3):E391-E400. Epub 2016 Sep 30.
    Deputy Director, National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, Kids Research Institute, The Children's Hospital at Westmead; New South Wales.
    Introduction: The Paediatric Active Enhanced Disease Surveillance (PAEDS) network is a hospital-based active surveillance system employing prospective case ascertainment of selected uncommon vaccine preventable diseases and potential adverse events following immunisation (AEFI). PAEDS enhances other Australian surveillance systems by providing prospective detailed clinical and laboratory data for the same child.

    Methods: Specialist surveillance nurses screen hospital admissions, emergency department records, laboratory and other data, to prospectively identify hospitalised children aged under 15 years in 5 paediatric tertiary referral hospitals in New South Wales, Victoria, South Australia, Western Australia and Queensland. Read More

    Severe varicella in persons vaccinated with varicella vaccine (breakthrough varicella): a systematic literature review.
    Expert Rev Vaccines 2017 Apr 28;16(4):391-400. Epub 2017 Feb 28.
    a Epidemiology Branch, Division of Viral Diseases , National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention , Atlanta , GA , USA.
    Introduction: Varicella vaccines are highly effective at preventing disease, but varicella may occur among vaccinated persons (termed breakthrough varicella). Breakthrough varicella is generally mild, but severe cases have been reported. The objective of this review is to describe severe breakthrough varicella. Read More

    The epidemiological situation of chickenpox in the Silesian voivodeship in the years 2011-2015 in view of data of the situation in Poland
    Przegl Epidemiol 2016 ;70(4):555-562
    Provincial Sanitary and Epidemiological Station in Katowice
    Introduction: Despite the availability of preventive vaccination against chickenpox, this form of prevention is rarely used and is not available to the entire population of children. In order to evaluate an acquired immunity against the virus Varicella-Zoster examining of the presence of specific IgG antibodies to VZV in serum or plasma is required. The aim of this study was to assess the epidemiological situation of chickenpox in Śląskie Voivodeship in 2011-2015. Read More

    Outcome of Dermal Grafting in the Management of Atrophic Facial Scars.
    J Cutan Aesthet Surg 2016 Oct-Dec;9(4):244-248
    Department of Dermatology, Venereology and Leprology, Bengaluru Medical College and Research Institute, Bengaluru, Karnataka, India.
    Background: Scars over the face are cosmetically and psychologically disturbing. Various techniques have been described and are being practiced in the management of these scars.

    Aims And Objectives: This study was undertaken to study the safety, effectiveness of using dermal grafts as fillers in the management of facial scars due to acne, chickenpox, trauma or any others. Read More

    Social Phobia Is Associated with Delayed Onset of Chickenpox, Measles, and Mumps Infections.
    Front Psychiatry 2016 27;7:203. Epub 2016 Dec 27.
    Department of Psychiatry, University Hospital of Lausanne , Lausanne , Switzerland.
    Objective: Evidence showing that infectious diseases in childhood play an important role in the etiopathogenesis of neurodevelopmental and other mental disorders is growing. The aim of this study was to explore the timing of common childhood diseases in early-onset anxiety disorders.

    Materials And Methods: We analyzed data from PsyCoLaus, a large Swiss Population Cohort Study (N = 3720). Read More

    The "Pearls" of Multidisciplinary Team: Conquering the Uncommon Rosette Rash.
    Case Rep Pediatr 2016 13;2016:5328603. Epub 2016 Dec 13.
    Department of Paediatric Dermatology, Darlington Memorial Hospital, County Durham and Darlington NHS Foundation Trust, Darlington, UK.
    Linear IgA disease of childhood (LAD) also known as chronic bullous disease of childhood is an autoimmune disease with IgA deposition at the basement membrane zone leading to a vesiculobullous rash. It has a clinical appearance which frequently is described as resembling "strings of pearls" or rosette-like. Diagnosis is usually clinical but sometimes biopsy is required. Read More

    Prevalence of Molar Incisor Hypomineralization in Mexican Children.
    J Clin Pediatr Dent 2017;41(1):18-21
    Objective: To determine the prevalence of and factors associated with molar incisor hypomineralization (MIH) in schoolchildren aged 6-12 years.

    Study Design: This study included 1156 schoolchildren aged 6-12 years, living in Mexico City. A previously standardised examiner (k = 0. Read More

    The influence of maternal exposure history to virus and medicine during pregnancy on congenital heart defects of fetus.
    Environ Sci Pollut Res Int 2017 Feb 30;24(6):5628-5632. Epub 2016 Dec 30.
    Guangzhou Huayin Medical Laboratory Center. CO. Ltd, Guangzhou, 510663, China.
    Congenital heart disease (CHD) is the most common birth defect. It is due to dysfunction of the heart and great vessels during embryo development stage, or the channel was not closed after birth. This study focuses on investigating the influence of virus infection and medicine history during pregnancy on the incidence rate of CHD of fetus. Read More

    Has VZV epidemiology changed in Italy? Results of a seroprevalence study.
    Hum Vaccin Immunother 2017 Feb 27;13(2):385-390. Epub 2016 Dec 27.
    b University of Ferrara , Ferrara , Italy.
    The aim of the study was to evaluate if and how varicella prevalence has changed in Italy. In particular a seroprevalence study was performed, comparing it to similar surveys conducted in pre-immunization era. During 2013-2014, sera obtained from blood samples taken for diagnostic purposes or routine investigations were collected in collaboration with at least one laboratory/center for each region, following the approval of the Ethics Committee. Read More

    Incidence of serum antibody titers against varicella zoster virus in Japanese patients with herpes zoster.
    J Dermatol 2016 Dec 24. Epub 2016 Dec 24.
    Department of Dermatology, Fukuoka University Faculty of Medicine, Fukuoka, Japan.
    Herpes zoster is an internal reactivation of varicella zoster virus following establishment of latent infection in the dorsal root ganglia during primary infection, which presents as chickenpox. Therefore, serologically, herpes zoster patients already have anti-varicella zoster virus immunoglobulin G at the onset of disease. Hence, positive serum antibody does not confirm the diagnosis of herpes zoster. Read More

    How often people google for vaccination: Qualitative and quantitative insights from a systematic search of the web-based activities using Google Trends.
    Hum Vaccin Immunother 2017 Feb 16;13(2):464-469. Epub 2016 Dec 16.
    g Department of Health Sciences , Section of History of Medicine and Ethics, University of Genoa , Genoa , Italy.
    Nowadays, more and more people surf the Internet seeking health-related information. Information and communication technologies (ICTs) can represent an important opportunities in the field of Public Health and vaccinology. The aim of our current research was to investigate a) how often people search the Internet for vaccination-related information, b) if this search is spontaneous or induced by media, and c) which kind of information is in particular searched. Read More

    Ocular involvement associated with varicella in adults.
    J Ophthalmic Inflamm Infect 2016 Dec 28;6(1):47. Epub 2016 Nov 28.
    Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia.
    Background: Varicella is a common infectious disease primarily of childhood that is usually benign and self-limited. It is, however, increasingly seen in adults who are at a higher risk of severe infection. Ocular complications of varicella are relatively uncommon and have been rarely described in adults. Read More

    Predicting risk factors for varicella zoster virus infection and postherpetic neuralgia after hematopoietic cell transplantation using ordered logistic regression analysis.
    Ann Hematol 2017 Feb 28;96(2):311-315. Epub 2016 Nov 28.
    Department of Hematology, Aiseikai Yamashina Hospital, Kyoto, Japan.
    To identify risk factors for varicella zoster virus (VZV) infection and postherpetic neuralgia (PHN) after hematopoietic cell transplantation (HCT), we conducted a retrospective chart review of 163 consecutive patients who underwent HCT between November 2004 and July 2014. Overall, the male/female (M/F) ratio was 80/83, median age at HCT was 54 (range 15-69) years, and autologous/allogeneic HCT (auto/allo-HCT) ratio was 71/92. Forty-four patients [M/F, 25/19; median age, 57 (range: 16-68) years; auto/allo-HCT, 26/18] developed VZV infection after HCT. Read More

    Vaccine-Preventable Diseases In Pediatric Patients: A Review Of Measles, Mumps, Rubella, And Varicella.
    Pediatr Emerg Med Pract 2016 Dec 2;13(12):1-20. Epub 2016 Dec 2.
    Clinical Associate Professor of Emergency Medicine and Pediatrics, New York University School of Medicine, Bellevue Hospital Center, New York, NY.
    Vaccine-preventable diseases such as measles, mumps, rubella, and varicella continue to plague children and adults worldwide. Although public health programs have helped decrease the prevalence and sequelae of these diseases, outbreaks still occur. To limit the spread of these diseases, emergency clinicians must be able to readily identify the characteristic presentations of the rashes associated with measles, rubella, and varicella, as well as the common presenting features associated with mumps. Read More

    A Case of Transverse Myelitis Caused by Varicella Zoster Virus in an Immunocompetent Older Patient.
    Infect Chemother 2016 Dec 11;48(4):334-337. Epub 2016 Nov 11.
    Deparment of Internal Medicine, Pusan National University School of Medicine, Medical Research Institute, Pusan National University Hospital, Busan, Korea.
    Varicella zoster virus (VZV) is a human neurotropic alphaherpesvirus that causes chickenpox (varicella) in children. VZV reactivation may lead to neurological complications, including transverse myelitis. However, transverse myelitis caused by VZV reactivation is rare in immunocompetent patients. Read More

    The burden of chickenpox disease in Sweden.
    BMC Infect Dis 2016 Nov 10;16(1):666. Epub 2016 Nov 10.
    Department of Monitoring and Evaluation, The Public Health Agency of Sweden, Solna, Sweden.
    Background: Chickenpox vaccine is not included in the routine childhood vaccination programme in Sweden. The aim of this study was to estimate the baseline of national chickenpox disease burden, as comprehensive studies, required for an assessment regarding vaccine introduction, are lacking.

    Methods: We used available health care registers and databases; the death register, hospitalisations register, communicable disease notifications database, Stockholm County registers on consultations in specialist and primary care, temporary parental benefit to care for a sick child, and searches on the health care system's website. Read More

    Effectiveness of Varicella Vaccination Program in Preventing Laboratory-Confirmed Cases in Children in Seoul, Korea.
    J Korean Med Sci 2016 Dec;31(12):1897-1901
    Seoul Center for Infectious Disease Control, Seoul, Korea.
    A universal one-dose varicella vaccination program was introduced in 2005 in Republic of Korea. However, the incidence of varicella in Korea has tripled over the last decade. We conducted a community based 1:1 matched case-control study to assess the effectiveness of one MAV strain-based vaccine and three Oka strain-based vaccines licensed for use in Korea. Read More

    Endovascular treatment using woven stents for ruptured vertebral artery dissecting aneurysm induced by varicella zoster virus: case report.
    Br J Neurosurg 2016 Dec 24;30(6):672-674. Epub 2016 May 24.
    a Department of Neurosurgery , Gyeongsang National University School of Medicine and Gyeongsang National University Hospital , Jinju , Republic of Korea.
    Subarachnoid hemorrhage with ruptured cerebral artery dissection caused by varicella zoster (VZ) vasculopathy is rare. We report a rare case of vertebral artery (VA) dissection induced by VZ virus, successfully treated with stent-assisted coil embolization and systemic anti viral medication, on six month follow-up cerebral angiography with the review of literatures. Read More

    The Glycoprotein B Cytoplasmic Domain Lysine Cluster Is Critical for Varicella-Zoster Virus Cell-Cell Fusion Regulation and Infection.
    J Virol 2017 Jan 16;91(1). Epub 2016 Dec 16.
    Departments of Pediatrics and Microbiology & Immunology, Stanford University School of Medicine, Stanford, California, USA.
    The conserved glycoproteins gB and gH-gL are essential for herpesvirus entry and cell-cell fusion induced syncytium formation, a characteristic of varicella-zoster virus (VZV) pathology in skin and sensory ganglia. VZV syncytium formation, which has been implicated in the painful condition of postherpetic neuralgia, is regulated by the cytoplasmic domains of gB (gBcyt) via an immunoreceptor tyrosine-based inhibition motif (ITIM) and gH (gHcyt). A lysine cluster (K894, K897, K898, and K900) in the VZV gBcyt was identified by sequence alignment to be conserved among alphaherpesviruses, suggesting a functional role. Read More

    Dysregulated Glycoprotein B-Mediated Cell-Cell Fusion Disrupts Varicella-Zoster Virus and Host Gene Transcription during Infection.
    J Virol 2017 Jan 16;91(1). Epub 2016 Dec 16.
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
    The highly conserved herpesvirus glycoprotein complex gB/gH-gL mediates membrane fusion during virion entry and cell-cell fusion. Varicella-zoster virus (VZV) characteristically forms multinucleated cells, or syncytia, during the infection of human tissues, but little is known about this process. The cytoplasmic domain of VZV gB (gBcyt) has been implicated in cell-cell fusion regulation because a gB[Y881F] substitution causes hyperfusion. Read More

    Chickenpox in Poland in 2014
    Przegl Epidemiol 2016;70(2):189-193
    National Institute of Public Health – National Institute of Hygiene in Warsaw, Department of Epidemiology
    Background: A large number of chickenpox cases, occurring especially in children between 0-14 years old and among those who are not vaccinated, indicates the rationale for the use of chickenpox vaccinations. In Poland since 2002, chickenpox vaccination is included in the National Immunisation Programme as recommended. AIM. Read More

    α Herpes Virus Infections Among Renal Transplant Recipients.
    Semin Nephrol 2016 Sep;36(5):344-350
    Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN; The William J. Von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN. Electronic address:
    The α herpes viruses HSV-1, HSV-2, and VZV often reactivate in the setting of immune suppression after solid organ transplantation. Oral or genital mucocutaneous disease is the most common clinical manifestation of HSV disease while VZV manifests as varicella (or chickenpox) or reactivation herpes zoster, characterized by a diffuse rash, or a painful unilateral vesicular eruption in a dermatomal distribution, respectively. The diagnosis of HSV and VZV is primarily based on history and clinical presentation, although diagnostic tests may be necessary for atypical presentations of disease. Read More

    [Vaccination status in psoriasis patients on immunosuppressant therapy (including biologics)].
    Ann Dermatol Venereol 2017 Feb 19;144(2):92-99. Epub 2016 Oct 19.
    Service de dermatologie, hôpitaux de Brabois, CHU de Nancy, 6, rue du Morvan, 54500 Vandœuvre-lès-Nancy, France.
    Objectives: To evaluate the vaccine coverage of psoriasis patients prior to initiating or changing immunosuppressant therapy, and to verify that the prescribed vaccines have been administered.

    Patients And Methods: We conducted a bi-centre, observational, cross-sectional study over 9 months. Psoriasis patients in whom immunosuppressant therapy (comprising cyclosporine, methotrexate, etanercept, infliximab, adalimumab or ustekinumab) was indicated were included. Read More

    Cerebral Sinus Venous Thrombosis as a Rare Complication of Primary Varicella Zoster Virus Infection.
    J Assoc Physicians India 2016 Jul;64(7):74-76
    Professor and Head of Medicine, Department of General Medicine, Coimbatore Medical College Hospital, Coimbatore, Tamil Nadu.
    We present the case of a 23 year old with acute onset left hemiparesis and meningeal irritation, associated with recent history of chickenpox 15 days prior. Varicella-IgG and IgM was positive in the CSF and blood along with reduced serum/CSF ratios of VZV immunoglobulins. MRV showed thrombosis (CVT) of superior sagittal, transverse, right sigmoid sinuses with haemorrhagic infarct in right frontoparietal region. Read More

    Varicella Vaccination of Children With Leukemia Without Interruption of Maintenance Therapy: A Danish Experience.
    Pediatr Infect Dis J 2016 Nov;35(11):e348-e352
    From the *Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Denmark; †Great Ormond Street Hospital, London, England; ‡Section of Biostatistics, Institute of Public Health, University of Copenhagen, Denmark; and §Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
    Background: Varicella-zoster virus (VZV) can be fatal or cause severe complications in children with acute lymphoblastic leukemia (ALL). This analysis set out to investigate the morbidity and mortality of VZV vaccination without interruption of maintenance therapy in children with ALL.

    Methods: Files of 73 seronegative children with ALL were examined for data regarding VZV vaccination and infection, and long-term seroconversion was measured. Read More

    Vaccination Coverage Among Children in Kindergarten - United States, 2015-16 School Year.
    MMWR Morb Mortal Wkly Rep 2016 Oct 7;65(39):1057-1064. Epub 2016 Oct 7.
    State-mandated vaccination requirements for school entry protect children and communities against vaccine-preventable diseases (1). Each school year, federally funded immunization programs (e.g. Read More

    Vaccination Coverage Among Children Aged 19-35 Months - United States, 2015.
    MMWR Morb Mortal Wkly Rep 2016 Oct 7;65(39):1065-1071. Epub 2016 Oct 7.
    Immunization Services Division, National Center for Immunization and Respiratory Diseases, CDC.
    Sustained high coverage with recommended vaccinations among children has kept many vaccine-preventable diseases at low levels in the United States (1). To assess coverage with vaccinations recommended for children by age 2 years in the United States (2), CDC analyzed data collected by the 2015 National Immunization Survey (NIS) for children aged 19-35 months (born January 2012-May 2014). Overall, coverage did not change during 2014-2015. Read More

    Postherpetic neuralgia: epidemiology, pathophysiology, and pain management pharmacology.
    J Multidiscip Healthc 2016 21;9:447-454. Epub 2016 Sep 21.
    Billings Clinic, Billings, MT, USA.
    Herpes zoster, also known as shingles, is a distinctive clinical condition caused by the reactivation of latent varicella zoster (chickenpox) virus following an initial infection. Approximately 1 million cases of herpes zoster occur annually in the US, and one in every three people develops herpes zoster during their lifetime. Postherpetic neuralgia is a neuropathic pain syndrome characterized by pain that persists for months to years after resolution of the herpes zoster rash. Read More

    Seroprotection against Vaccine-Preventable Diseases amongst Health Care Workers in a Community Hospital, Qatar.
    Int J Occup Environ Med 2016 Oct;7(4):234-40
    The Cuban Hospital, Hamad Medical Corporation, Dukham 27555, Qatar.
    Background: Health care workers (HCW) are at high risk of contracting various infectious diseases and play a dual role in the transmission of infections in health care facilities.

    Objective: To determine the seroprotection against hepatitis B, measles, rubella, and varicella among HCWs in a community hospital in Qatar.

    Methods: This is a cross-sectional survey conducted in a 75-bed community hospital in Dukhan, Qatar. Read More

    Attitudinal variables and a possible mediating mechanism for vaccination practice in health care workers of a local hospital in L'Aquila (Italy).
    Hum Vaccin Immunother 2017 Jan 13;13(1):198-205. Epub 2016 Sep 13.
    a Department of Life, Health & Environmental Sciences - University of L'Aquila , L'Aquila , Italy.
    Active immunization is an important concern for health care workers (HCWs) susceptible subjects and potential sources of infection for patients. However, the vaccine coverage for vaccine preventable diseases (VPDs) is below recommended standards. The aims of the study were to estimate the hospitals' HCWs' susceptibility and vaccination coverage rates for VPDs and to analyze the role of HCWs' attitudes and knowledge as determinants of the immunization practices. Read More

    Intracerebral hemorrhage caused by varicella-induced thrombocytopenia.
    Biomedica 2016 Feb 16;36(0):10-3. Epub 2016 Feb 16.
    Departamento de Medicina Interna, Hospital Universitario Erasmo Meoz, Cúcuta, Colombia.
    We present the case of a previously healthy 44-years-old man with chickenpox, severe thrombocytopenia, mucosal hemorrhage, and intracerebral hemorrhage in the right hemisphere. The patient was treated with platelets and high doses of steroids. He recovered although with persistent left homonymous hemianopsia and epilepsy, which were controlled with medication. Read More

    Notes from the Field: Varicella Outbreak Associated with Riding on a School Bus - Muskegon County, Michigan, 2015.
    MMWR Morb Mortal Wkly Rep 2016 Sep 9;65(35):941-2. Epub 2016 Sep 9.
    On December 3, 2015, Public Health-Muskegon County (PHMC) in Michigan was notified by a local kindergarten-grade 2 school that a student aged 8 years (the index patient) had been sent home because of a rash suspected to be varicella (chickenpox); the rash had not been observed the previous day. Investigation by PHMC revealed that the student was one of five siblings in household A, none of whom had a history of having received any immunizations. During the preceding month the index patient's two older siblings (aged 12 years and 25 years) and two younger siblings (twins, aged 4 years) had been excluded from other schools in this rural district because of rashes that also were suspected to be varicella. Read More

    Epidemiology of Varicella During the 2-Dose Varicella Vaccination Program - United States, 2005-2014.
    MMWR Morb Mortal Wkly Rep 2016 Sep 2;65(34):902-5. Epub 2016 Sep 2.
    Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, CDC.
    Before availability of varicella vaccine in the United States, an estimated 4 million varicella cases, 11,000-13,500 varicella-related hospitalizations, and 100-150 varicella-related deaths occurred annually. The varicella vaccination program was implemented in the United States in 1996 as a 1-dose routine childhood program. Based on data from two varicella active surveillance sites, the varicella vaccination program led to 90% decline in incidence over the next decade (1). Read More

    Sudden, unexpected death of a 15-year-old boy due to pancarditis: A case report and possible etiopathogenesis.
    Medicine (Baltimore) 2016 Aug;95(35):e4586
    aDepartment of Public Health, Experimental and Forensic Medicine, Section of Legal Medicine and Forensic Sciences "Antonio Fornari," University of Pavia, Pavia bDepartment of Legal and Forensic Medicine, University of Genoa, Genova, Italy cMedico Legal Service of Canton Ticino, Bellinzona, Switzerland.
    Background: Generally, rheumatic heart disease is, today, sporadic in developed countries, even though it continues to be a major health hazard in the developing ones. It is also a very rare cause of sudden unexpected death. We report a case of a 15-year-old boy who suddenly died at home. Read More

    Prevalence and Characteristics of Pediatric Healthcare Workers without Immunity to Varicella zoster Virus.
    Jpn J Infect Dis 2017 Mar 31;70(2):216-218. Epub 2016 Aug 31.
    Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University.
    This study aimed to determine the proportion of varicella non-immune pediatric healthcare workers (HCWs) of the Pediatrics Department of King Chulalongkorn Memorial Hospital and to determine cost-effective strategies for identifying non-immune personnel. A cross-sectional study using a self-administered questionnaire to determine HCWs' histories of chickenpox or 2-dose varicella vaccination was conducted. From a total of 699 HCWs, 653 HCWs (93%), including 145 physicians (22%), 297 nurses (46%), and 211 administrative staff (32%), responded to questionnaires. Read More

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