281,529 results match your criteria Chest Medicine On-Line[Journal]


The Advantages of Adding Rib Fixations during VATS for Retained Hemothorax in Serious Blunt Chest Trauma - A Prospective Cohort Study.

Int J Surg 2019 Mar 13. Epub 2019 Mar 13.

Division of Thoracic Surgery, Department of Surgery, Kaohsiung-Veterans General Hospital, Kaohsiung, Taiwan; Division of Trauma, Department of Emergency, Kaohsiung-Veterans General Hospital, Kaohsiung, Taiwan; Department of Cosmetic Science, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan. Electronic address:

Background: Serious blunt chest trauma usually induces hemothorax, pneumothorax, and rib fracture. Early video-assisted thoracoscopic surgery (VATS) to evacuate retained hemothorax is one commonly used treatment. In this study, a new strategy was implemented to combine VATS with fractured rib fixation simultaneously. Read More

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http://dx.doi.org/10.1016/j.ijsu.2019.02.022DOI Listing

Routine monitoring for heparin-induced thrombocytopenia following lower limb arthroplasty: Is it necessary? A prospective study in a UK district general hospital.

Orthop Traumatol Surg Res 2019 Mar 13. Epub 2019 Mar 13.

York Hospital NHS Foundation Trust, Wiggington Road, York, YO31 8HE, United Kingdom.

Introduction: Heparin-induced thrombocytopenia (HIT) is a potentially life-threatening condition associated with heparin administration. Many orthopaedic units routinely prescribe low-molecular-weight heparins as thromboprophylaxis after hip and knee arthroplasty.

Hypothesis: We postulated that routine platelet monitoring following heparin administration is of no clinical benefit. Read More

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http://dx.doi.org/10.1016/j.otsr.2018.12.012DOI Listing

Effectiveness of the Chest Strap Electrocardiogram to Detect Atrial Fibrillation.

Am J Cardiol 2019 Feb 23. Epub 2019 Feb 23.

Center for Prehospital Emergency Care, Kuopio University Hospital, Kuopio, Finland; University of Eastern Finland, Faculty of Health Sciences, Kuopio, Finland.

Atrial fibrillation (AF) is a significant cause of cardioembolic strokes. AF is often symptomless and intermittent, making its detection challenging. The aim of this study was to assess the possibility to use a chest strap (Suunto Movesense) to detect AF both by cardiologists and automated algorithms. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.02.028DOI Listing
February 2019

Tuberculosis - Depression syndemic: A public health challenge.

Indian J Tuberc 2019 Jan 26;66(1):197-202. Epub 2019 Feb 26.

Santosh University, Ghaziabad, UP, India; National Institute of Tuberculosis and Respiratory Diseases, Delhi, India; JIPMER, Pondicherry, India. Electronic address:

Introduction: Depression is common in Tuberculosis (TB) and associated with adverse outcomes through pathogenic mechanisms and impaired self-care behaviours including reduced treatment adherence. Undiagnosed depression can threaten the robustness of DOTS model despite large public health investment. The Depression-Tuberculosis Syndemic requires collaborative partnership with mental health professionals. Read More

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http://dx.doi.org/10.1016/j.ijtb.2019.02.007DOI Listing
January 2019

Burden of pulmonary tuberculosis in modern prison: A cross sectional prevalence survey from south India.

Indian J Tuberc 2019 Jan 13;66(1):189-192. Epub 2018 Nov 13.

ICMR-National Institute for Research in Tuberculosis, Chennai, Tamil Nadu State, India.

Background: The risk of spread of Pulmonary Tuberculosis (PTB) disease depends on several factors. One important factor is the situational and environmental vulnerabilities of the prison setting. Study was conducted in central prison in Chennai, south state, India to estimate the prevalence of PTB disease in 2013. Read More

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http://dx.doi.org/10.1016/j.ijtb.2018.10.007DOI Listing
January 2019
1 Read

Active tuberculosis case finding in India - The way forward.

Indian J Tuberc 2019 Jan 1;66(1):170-177. Epub 2018 Jun 1.

Epidemiology and Research Division, National Tuberculosis Institute, Bangalore, Karnataka, India.

Community based active case finding (ACF) for tuberculosis (TB) has seen resurrection in the current armamentarium of many TB managers in their fight toward eliminating TB. This article explores the accuracy and approximate cost of various ACF algorithms currently in vogue in India or those which could be useful, while inputting the sensitivity and specificity of screening and diagnostic tools as estimated from recently conducted community based surveys. This analysis informs that ACF may be prioritized to higher prevalence settings and the diagnostic algorithm for specific setting may be chosen taking into account the expected prevalence, estimated accuracy of the algorithm and resource availability. Read More

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http://dx.doi.org/10.1016/j.ijtb.2018.05.014DOI Listing
January 2019

Risk factors of relapse in pulmonary sarcoidosis treated with corticosteroids.

Clin Rheumatol 2019 Mar 15. Epub 2019 Mar 15.

Department of Pulmonary and Critical Care Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing, 210008, Jiangsu, China.

Objective: To evaluate the incidence and risk factors of relapse in pulmonary sarcoidosis treated with corticosteroids.

Methods: Medical records of patients with pulmonary sarcoidosis were retrospectively reviewed. Clinical features, chest radiographs, pulmonary function tests, and treatment information were collected. Read More

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http://link.springer.com/10.1007/s10067-019-04507-3
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http://dx.doi.org/10.1007/s10067-019-04507-3DOI Listing
March 2019
4 Reads

X-ray examination dose surveys: how accurate are my results?

Eur Radiol 2019 Mar 15. Epub 2019 Mar 15.

Department of Radiology, EPICURA, Clinique Louis Caty, Rue Louis Caty 136, 7331, Baudour, Belgium.

Objectives: To determine the variabilities of dose-area-products (DAP) of frequent X-ray examinations collected for comparison with diagnostic reference levels (DRLs).

Methods: DAP values of chest, abdomen, and lumbar spine examinations obtained on devices from two manufacturers were collected in three centers over 1 to 2 years. The variability of the average DAP results defined as the 95% confidence interval in percentage of their median value was calculated for increasing sample sizes, each examination and center. Read More

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http://dx.doi.org/10.1007/s00330-019-06055-5DOI Listing

Breast Reconstruction in Poland Syndrome Patients with Latissimus Dorsi Myo Flap and Implant: An Efficient Endoscopic Approach Using Single Transverse Axillary Incision.

Aesthetic Plast Surg 2019 Mar 14. Epub 2019 Mar 14.

Department of Aesthetic and Reconstructive Breast Surgery, Plastic Surgery Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 33 Badachu Road, Shijingshan District, Beijing, 100144, China.

Background: Breast hypoplasia or amastia with pectoralis major muscle defect in female Poland syndrome patients always necessitates surgical intervention. This study aims to introduce an efficient endoscopic technique to perform breast reconstruction in Poland syndrome patients with a latissimus dorsi myo flap and an implant using a single transverse axillary incision (ELDM + IMPLANT) and to evaluate its safety and effectiveness.

Methods: A prospective study was designed to recruit Poland syndrome candidates for ELDM + IMPLANT breast reconstruction. Read More

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http://dx.doi.org/10.1007/s00266-019-01346-0DOI Listing
March 2019
1 Read

Three-dimensional printed models of the rib cage in children with non-accidental injury as an effective visual-aid tool.

Pediatr Radiol 2019 Mar 15. Epub 2019 Mar 15.

Department of Radiology, The Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA.

Three-dimensional (3-D) printing is gaining terrain in medical education, presurgical evaluation and recently as forensic evidence in court. Physicians, including radiologists, often provide expert testimony in court cases involving children with rib fractures and other injuries concerning for child physical abuse. Effectively communicating the complexities of fractures and other skeletal findings to nonmedical personnel using standard radiology studies can be challenging, especially during medical courtroom testimony. Read More

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http://dx.doi.org/10.1007/s00247-019-04368-7DOI Listing

Oxacillin-Induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS).

Am J Case Rep 2019 Mar 16;20:345-348. Epub 2019 Mar 16.

Department of Pulmonary and Critical Care, NYU Langone, New York City, NY, USA.

BACKGROUND Drug reaction with eosinophilia and systemic symptoms (DRESS) is an idiosyncratic life-threatening reaction comprised of fevers, rash, and leukocytosis with eosinophilia. Though characteristically associated with leukocytosis, there are rare case reports of DRESS-induced agranulocytosis. DRESS is most frequently caused by antiepileptic medications; however, it has very rarely been reported in relation to oxacillin. Read More

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http://dx.doi.org/10.12659/AJCR.913748DOI Listing

Targeted next-generation sequencing detects rare genetic events in pheochromocytoma and paraganglioma.

J Med Genet 2019 Mar 15. Epub 2019 Mar 15.

Genetics department, Assistance Publique-Hôpitaux de Paris, Hôpitaleuropéen Georges Pompidou, F-75015, Paris, France.

Background: Knowing the genetic status of patients affected by paragangliomas and pheochromocytomas (PPGL) is important for the guidance of their management and their relatives. Our objective was to improve the diagnostic performances of PPGL genetic testing by next-generation sequencing (NGS).

Methods: We developed a custom multigene panel, which includes 17 PPGL genes and is compatible with both germline and tumour DNA screening. Read More

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http://dx.doi.org/10.1136/jmedgenet-2018-105714DOI Listing

Long-term medical and psychosocial outcomes in congenital diaphragmatic hernia survivors.

Arch Dis Child 2019 Mar 15. Epub 2019 Mar 15.

Division of Obstetrics and Gynaecology, University of Western Australia Faculty of Health and Medical Sciences, Perth, Western Australia, Australia.

Objective: Survival rates for congenital diaphragmatic hernia (CDH) are increasing. The long-term outcomes of CDH survivors were compared with a healthy control group to assess the morbidity for guidance of antenatal counselling and long-term follow-up programmes.

Participants And Design: Participants born with CDH in Western Australia 1993-2008 were eligible with matched controls from the general population. Read More

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http://dx.doi.org/10.1136/archdischild-2018-316091DOI Listing

Visfatin promotes the malignancy of human acute myeloid leukemia cells via regulation of IL-17.

Eur J Pharmacol 2019 Mar 12. Epub 2019 Mar 12.

Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, China. Electronic address:

Understanding the mechanisms of malignancy in acute myeloid leukemia (AML) cell is important for the targeted treatment and drug development. We found that visfatin, a 52-kDa adipokine, can positively regulate the proliferation of AML cells. Targeted inhibition of visfatin via its specific siRNAs or inhibitor can suppress the proliferation of AML cells. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.03.016DOI Listing

Exploring the relevance and extent of small airways dysfunction in asthma (ATLANTIS): baseline data from a prospective cohort study.

Lancet Respir Med 2019 Mar 12. Epub 2019 Mar 12.

University of Arizona College of Medicine, Department of Medicine, Tucson, AZ, USA.

Background: Small airways dysfunction (SAD) is well recognised in asthma, yet its role in the severity and control of asthma is unclear. This study aimed to assess which combination of biomarkers, physiological tests, and imaging markers best measure the presence and extent of SAD in patients with asthma.

Methods: In this baseline assessment of a multinational prospective cohort study (the Assessment of Small Airways Involvement in Asthma [ATLANTIS] study), we recruited participants with and without asthma (defined as Global Initiative for Asthma severity stages 1-5) from general practices, the databases of chest physicians, and advertisements at 29 centres across nine countries (Brazil, China, Germany, Italy, Spain, the Netherlands, the UK, the USA, and Canada). Read More

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http://dx.doi.org/10.1016/S2213-2600(19)30049-9DOI Listing

Pericarditis - Clinical presentation and characteristics of a pediatric population.

Rev Port Cardiol 2019 Mar 12. Epub 2019 Mar 12.

Serviço de Cardiologia Pediátrica, Hospital de Santa Marta, Centro Hospitalar de Lisboa Central, EPE, Lisboa, Portugal.

Introduction: Pericarditis is an inflammation of the pericardium. It may be infectious or secondary to a systemic disease. The aim of this study was to analyze the clinical findings, course, treatment and follow-up of children diagnosed with pericarditis at our center. Read More

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http://dx.doi.org/10.1016/j.repc.2018.05.017DOI Listing

Efficient ten-gene analysis of NSCLC tissue samples by next-generation sequencing.

Pathol Res Pract 2019 Feb 27. Epub 2019 Feb 27.

Pathology Department, The First Affiliated Hospital, Wenzhou Medical University, 325003, Wenzhou, China. Electronic address:

In the era of personalized medicine, lung cancer is a typical disease which can be treated strategically based on the patient's histological and molecular diagnosis. Immunohistochemistry (IHC), fluorescence in-situ hybridization (FISH), Sanger sequencing and real-time PCR are techniques commonly used in clinical laboratories. Many patients are required to use several of the above technologies to get a complete diagnosis, which is expensive and timeconsuming. Read More

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http://dx.doi.org/10.1016/j.prp.2019.02.017DOI Listing
February 2019

Ground-glass opacity is a strong prognosticator for pathologic stage IA lung adenocarcinoma.

Ann Thorac Surg 2019 Mar 12. Epub 2019 Mar 12.

Division of Thoracic Surgery, Department of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan.

Background: A ground-glass opacity (GGO) component on chest computed tomography (CT) pathologically corresponds to lepidic adenocarcinoma. However, the precise correspondence relation and the prognostic significance of them remains unclear in patients with pathologic stage IA lung adenocarcinoma.

Methods: We retrospectively reviewed the clinicopathologic features of 809 consecutive patients with pathologic stage IA lung adenocarcinoma who underwent complete resection between 2003 and 2014. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.079DOI Listing

No in vitro synergistic effect of bedaquiline combined with fluoroquinolones, linezolid, and clofazimine against extensively drug-resistant tuberculosis.

Diagn Microbiol Infect Dis 2019 Feb 19. Epub 2019 Feb 19.

Department of Tuberculosis, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China. Electronic address:

Purpose: We explored the potential synergistic effect of bedaquiline (BDQ) combined with moxifloxacin (MFX), gatifloxacin (GAT), clofazimine (CLO), and linezolid (LZD) for treatment of extensively drug-resistant tuberculosis (XDR-TB).

Methods: Of 191 XDR-TB isolates, 20 exhibiting minimal inhibitory concentration (MIC) values ≥0.063 μg/mL for BDQ were selected to study potential synergistic, additive, or antagonistic drug effects using a checkerboard assay. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2019.02.012DOI Listing
February 2019
2.457 Impact Factor

Percutaneous coronary intervention for a Chinese familial hypercholesterolemia homozygous under the guidance of optical coherence tomography.

Atheroscler Suppl 2019 Mar;36:19-23

Beijing Anzhen Hospital, Capital Medical University - Beijing Institute of Heart, Lung and Blood Vessel Diseases, 100029, China; Department of Atherosclerosis, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China. Electronic address:

Homozygous familial hypercholesterolemia developed into severe cardiovascular consequences early. Untreated HoFH usually cannot survive over 30 years old. Acute coronary syndrome(ACS) caused by plaque rupture is one of the main causes of death in HoFH. Read More

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http://dx.doi.org/10.1016/j.atherosclerosissup.2019.01.004DOI Listing

Malignant perivascular epithelioid cell tumor of the lung synchronous with a primary adenocarcinoma: one case report and review of the literature.

BMC Cancer 2019 Mar 15;19(1):235. Epub 2019 Mar 15.

Department of Pathology, Shanghai Chest Hospital, Shanghai Jiao Tong University, No. 241 West Huaihai Road, Shanghai, 200030, China.

Background: Perivascular Epithelioid Cell Tumors (PEComa) is an extraordinarily rare mesenchymal neoplasm especially the malignant type originating from the lung. To date, only 8 cases of malignant or malignant potential pulmonary PEComa had been documented. Firm diagnostic criteria for malignant pulmonary PEComa need urgently to be established. Read More

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http://dx.doi.org/10.1186/s12885-019-5383-0DOI Listing

A new gentle reduction technique for patients with congenital diaphragmatic hernia-A case report.

Int J Surg Case Rep 2019 Mar 6;57:5-8. Epub 2019 Mar 6.

Department of Pediatric Surgery, University Medicine Mainz, Germany.

Reducing the herniated viscera such as the spleen, the liver, and the bowel in thoracoscopic repair of congenital diaphragmatic hernia can be challenging. The small instruments involved can easily create damage, particularly to the friable capsule of the solid organs involved. We herein demonstrate a new gentle method of reducing the diaphragmatic hernia using sequential twisting of the sac. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.001DOI Listing

Rhabdomyosarcoma disease spread evaluation on CT scans: Association with primary tumor size and Ki-67 proliferation marker.

Clin Imaging 2019 Feb 12;56:41-46. Epub 2019 Feb 12.

Tel Aviv University, Sackler Faculty of Medicine, Einstein St 68, Tel Aviv, Israel; Department of Diagnostic Imaging, the Chaim Sheba Medical Center at Tel HaShomer, Emek HaEla St 1, Ramat Gan, Israel.

Purpose: Ki-67 is a marker of cellular proliferation that is commonly used for the assessment of rhabdomyosarcoma. The aim of this study was to investigate the associations between Ki-67 expression and primary tumor diameter with CT evidence of lymph node and solid organ metastatic spread in rhabdomyosarcoma.

Materials And Methods: An institutional review board approval was granted for this study. Read More

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http://dx.doi.org/10.1016/j.clinimag.2019.02.009DOI Listing
February 2019

Sugammadex and postoperative myasthenic crisis.

J Clin Anesth 2019 Mar 12;57:63. Epub 2019 Mar 12.

Department of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.jclinane.2019.02.026DOI Listing

Quality of Life and Lung Function in Survivors of Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome.

Anesthesiology 2019 Apr;130(4):572-580

From the Department of Anesthesia, Critical Care, and Emergency, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda - Ospedale Maggiore Policlinico, Milan (MI), Italy (G.G., V.S., D.T., R.R., A.P.) Department of Pathophysiology and Transplantation, University of Milan, Milan (MI), Italy (G.G., F.C., F.B., L.C.M., E.S., A.P.) Department of Preventive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda - Ospedale Maggiore Policlinico, Milan (MI), Italy (L.P.) Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Göttingen, Germany (L.G.) Department of Health Sciences, University of Milan, Milan (MI), Italy (D.C.).

What We Already Know About This Topic: Extracorporeal membrane oxygenation is used in severe acute respiratory distress syndrome; whereas the long-term complications among survivors of acute respiratory distress syndrome treated without extracorporeal membrane oxygenation are well described, the status of extracorporeal membrane oxygenation survivors is poorly understood WHAT THIS ARTICLE TELLS US THAT IS NEW: In a single-center cohort of acute respiratory distress syndrome survivors, management with (vs. without) extracorporeal membrane oxygenation resulted in similar survival at 1 yr, pulmonary function, and computed tomography lung imaging, but less impairment in quality of life BACKGROUND:: Survivors of acute respiratory distress syndrome (ARDS) have long-term impairment of pulmonary function and health-related quality of life, but little is known of outcomes of ARDS survivors treated with extracorporeal membrane oxygenation. The aim of this study was to compare long-term outcomes of ARDS patients treated with or without extracorporeal membrane oxygenation. Read More

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http://Insights.ovid.com/crossref?an=00000542-201904000-0001
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http://dx.doi.org/10.1097/ALN.0000000000002624DOI Listing
April 2019
5 Reads

Is Chest Computed Tomography Always Necessary Following Nephrectomy for Renal Cell Carcinoma? A Pilot Study in Single Tertiary Institution.

J Comput Assist Tomogr 2019 Mar/Apr;43(2):333-337

Pathology, Yonsei University College of Medicine.

Purpose: We evaluated patterns of thoracic recurrence from renal cell carcinoma (RCC) following nephrectomy as a pilot study.

Methods: Data of consecutive 39 patients who had recurrent RCC in the abdomen or thorax following curative nephrectomy were evaluated. Recurrence sites were analyzed with abdomen and chest computed tomography (CT), or positron emission tomography/CT. Read More

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http://dx.doi.org/10.1097/RCT.0000000000000841DOI Listing

Internal medicine residents' evaluation of fevers overnight.

Diagnosis (Berl) 2019 Mar 15. Epub 2019 Mar 15.

Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Background Scant data exists to guide the work-up for fever in hospitalized patients, and little is known about what diagnostic tests medicine residents order for such patients. We sought to analyze how cross-covering medicine residents address fever and how sign-out systems affect their response. Methods We conducted a prospective cohort study to evaluate febrile episodes that residents responded to overnight. Read More

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http://dx.doi.org/10.1515/dx-2018-0066DOI Listing

Clinical Diagnosis Value of Chest X-Ray and Ultrasound in Recurrence in Patients With Favorable-Histology Wilms Tumor.

J Clin Oncol 2019 Mar 15:JCO1801886. Epub 2019 Mar 15.

1 Lulu Xie, MD; Baihui Liu, MD; and Kuiran Dong, PhD, Children's Hospital of Fudan University, Shanghai, People's Republic of China.

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http://dx.doi.org/10.1200/JCO.18.01886DOI Listing

Mid-Term Reproducibility of Chest MRI in Adults with Clinically Stable Cystic Fibrosis and Chronic Obstructive Pulmonary Disease.

Am J Respir Crit Care Med 2019 Mar 15. Epub 2019 Mar 15.

Thoraxklinik at University Hospital Heidelberg, Diagnostic and Interventional Radiology with Nuclear Medicine, Heidelberg, Germany.

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https://www.atsjournals.org/doi/10.1164/rccm.201812-2356LE
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http://dx.doi.org/10.1164/rccm.201812-2356LEDOI Listing
March 2019
3 Reads

[Chest pain after angiography without anomalies].

Ned Tijdschr Geneeskd 2019 Mar 1;163. Epub 2019 Mar 1.

Zaans Medisch Centrum, afd. Cardiologie, Zaandam.

Background: Myocardial infarction can be categorized based on ECG-findings (presence or absence of ST-elevations on STEMI/NSTEMI) or on the results from coronary angiography (CAG) (presence or absence of obstructive atherosclerosis). Myocardial infarction without significant obstruction on CAG (Myocardial Infarction with Non-Obstructive Coronary Arteries/Atherosclerosis; MINOCA) occurs in up to a quarter of patients with myocardial infarcts. These patients have a higher risk of future heart diseases; up to a quarter of MINOCA patients suffer from heart diseases during a median follow-up of four years. Read More

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[Unusual findings on chest x-ray].

Ned Tijdschr Geneeskd 2019 Mar 11;163. Epub 2019 Mar 11.

Spaarne Gasthuis, afd. Radiologie, Haarlem/Hoofddorp.

We describe a 59-year-old woman, who came to the Emergency Room with fever, dyspnoea and lung abnormalities on chest x-ray. The X-ray abnormalities were not related to the clinical symptoms and could be explained by the patient's medical history, which included rib fractures and spinal compression fractures. The confined spherical structures visible on chest X-ray were indicative of previous rib fractures. Read More

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Exercise-Induced Dyspnea in Children and Adolescents: Differential Diagnosis.

Pediatr Ann 2019 Mar;48(3):e121-e127

Exercise-induced dyspnea in children and adolescents can occur for many reasons. Although asthma is the common cause, failure to prevent exercise-induced asthma by pretreatment with a bronchodilator, such as albuterol, indicates that other etiologies should be considered. Other causes of exercise-induced dyspnea include exercise-induced vocal cord dysfunction, exercise-induced laryngomalacia, exercise-induced hyperventilation, chest wall restrictive abnormalities, cardiac causes, and normal physiologic limitation. Read More

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http://dx.doi.org/10.3928/19382359-20190219-02DOI Listing

Persistent Wheeze in Infants: A Guide for General Pediatricians.

Pediatr Ann 2019 Mar;48(3):e110-e114

Infants with persistent wheeze is a common diagnostic challenge for the general pediatrician because of the broad differential diagnoses. The initial diagnostic approach should include a comprehensive history, physical examination, and chest radiography. Additional testing may be warranted. Read More

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http://dx.doi.org/10.3928/19382359-20190222-02DOI Listing

Clinical and microbiological characteristics of paracoccidioidomycosis in patients with AIDS in Buenos Aires, Argentina.

Med Mycol 2019 Mar 15. Epub 2019 Mar 15.

Mycology Unit of the Infectious Diseases Hospital F.J. Muñiz, Reference Center of Mycology of Buenos Aires city, Argentina.

Paracoccidioidomycosis (Pm) is a systemic disease, endemic in the American continent. There are two different clinical forms, the infant-juvenile or subacute form (PmS) and the chronic adult form (PmC). The human immunodeficiency virus (HIV) associated paracoccidioidomycosis (PmHIV) shares characteristics with both of the previously mentioned forms. Read More

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http://dx.doi.org/10.1093/mmy/myz021DOI Listing

Diagnostic Accuracy of Point-of-Care Lung Ultrasonography and Chest Radiography in Adults With Symptoms Suggestive of Acute Decompensated Heart Failure: A Systematic Review and Meta-analysis.

JAMA Netw Open 2019 Mar 1;2(3):e190703. Epub 2019 Mar 1.

Division of Cardiology, University of Colorado School of Medicine, Aurora.

Importance: Standard tools used to diagnose pulmonary edema in acute decompensated heart failure (ADHF), including chest radiography (CXR), lack adequate sensitivity, which may delay appropriate diagnosis and treatment. Point-of-care lung ultrasonography (LUS) may be more accurate than CXR, but no meta-analysis of studies directly comparing the 2 tools was previously available.

Objective: To compare the accuracy of LUS with the accuracy of CXR in the diagnosis of cardiogenic pulmonary edema in adult patients presenting with dyspnea. Read More

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http://jamanetworkopen.jamanetwork.com/article.aspx?doi=10.1
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http://dx.doi.org/10.1001/jamanetworkopen.2019.0703DOI Listing
March 2019
1 Read

Antithrombotic treatment in patients with atrial fibrillation and acute coronary syndromes: results of the European Heart Rhythm Association survey.

Europace 2019 Mar 14. Epub 2019 Mar 14.

School of Medicine, Belgrade University; Cardiology Clinic, Clinical Center of Serbia, Belgrade, Serbia.

The management of an acute coronary syndrome (ACS) in a patient with existing atrial fibrillation (AF) often presents a management dilemma both in the acute phase and post-ACS, since the majority of AF patients will already be receiving oral anticoagulation (OAC) for stroke prevention and will require further antithrombotic treatment to reduce the risk of in-stent thrombosis or recurrent cardiac events. Current practice recommendations are based largely on consensus option as there is limited evidence from randomized controlled trials. Prior to the launch of the new European Heart Rhythm Association (EHRA) consensus document, a survey was undertaken to examine current clinical management of these patients across centres in Europe. Read More

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https://academic.oup.com/europace/advance-article/doi/10.109
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http://dx.doi.org/10.1093/europace/euz033DOI Listing
March 2019
2 Reads

Outcomes of incidental findings on multi-detector computed tomography for transcatheter aortic valve implantation assessment: A single-centre study and review of the literature.

J Med Imaging Radiat Oncol 2019 Mar 15. Epub 2019 Mar 15.

Department of Cardiology, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.

Introduction: Patients with severe aortic stenosis (AS) require multi-detector computed tomography (MDCT) when considered for transcatheter aortic valve implantation (TAVI). Incidental findings on MDCT are common given the age group and region imaged. Our aim was to evaluate the frequency and outcome of incidental findings (IF) identified on MDCT and the impact on survival. Read More

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http://dx.doi.org/10.1111/1754-9485.12872DOI Listing

Generation of virtual lung single-photon emission computed tomography/CT fusion images for functional avoidance radiotherapy planning using machine learning algorithms.

J Med Imaging Radiat Oncol 2019 Mar 15. Epub 2019 Mar 15.

Department of Radiation Oncology, Seoul National University Hospital, Seoul, Korea.

Introduction: Functional image-guided radiotherapy (RT) planning for normal lung avoidance has recently been introduced. Single-photon emission computed tomography (SPECT)/CT can help identify the functional areas of lungs, but it is associated with delayed treatment time, additional costs and unexpected radiation exposure. In this study, we propose a machine learning algorithm that can generate functional chest CT images using the conditional generative adversarial networks (cGANs). Read More

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http://dx.doi.org/10.1111/1754-9485.12868DOI Listing

Limitations of Quantitative Blush Evaluator (QuBE) as myocardial perfusion assessment method on digital coronary angiograms.

J Clin Transl Res 2018 Jul 2;3(Suppl 2):394-400. Epub 2018 Jul 2.

Department of Biomedical Engineering Physics, Academic Medical Center, Amsterdam, the Netherlands.

Background And Aim: Quantitative Blush Evaluator (QuBE) is a software application that allows quantifying myocardial perfusion in coronary angiograms after a percutaneous coronary intervention. QuBE has some limitations such as the application of a crude filter to remove large scale structures and the absence of correction for cardiac motion. This study investigates the extent of these limitations and we hypothesize that enhanced image analysis methods can provide improvements. Read More

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Birt-Hogg-Dubé syndrome in the elderly.

J Gen Fam Med 2019 Mar 21;20(2):72-73. Epub 2018 Dec 21.

Department of Pulmonary Medicine Yokkaichi Municipal Hospital Yokkaichi-shi, Mie Japan.

We present the case of a 73-year-old woman who developed pneumothorax for the first time that was a clinical clue to the diagnosis of Birt-Hogg-Dubé (BHD) syndrome. Although younger onset of pneumothorax is more common in BHD syndrome, the characteristic chest CT findings may contribute to the diagnosis of this disorder in spontaneous pneumothorax of the elderly. Read More

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http://dx.doi.org/10.1002/jgf2.227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399594PMC

Physical assessment by Japanese community hospital nurses compared to that performed overseas: A cross-sectional study.

J Gen Fam Med 2019 Mar 21;20(2):55-61. Epub 2018 Dec 21.

Community Care Unnan City Hospital Unnan Shimane Japan.

Background: Japanese nurses may not be adequately trained to perform physical assessments compared to nurses overseas due to differences in accessibility to education; currently, research investigating this discrepancy is limited. This study investigated the current performance levels of Japanese community nurses in physical assessments and compared their performance to that of nurses overseas.

Methods: In this cross-sectional study, we examined the practical application of physical assessments conducted by nurses at a Japanese community hospital. Read More

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http://dx.doi.org/10.1002/jgf2.230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399597PMC

Identification of Key lncRNAs Associated With Atherosclerosis Progression Based on Public Datasets.

Front Genet 2019 28;10:123. Epub 2019 Feb 28.

Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

Atherosclerosis is one of the most common type of cardiovascular disease and the prime cause of mortality in the aging population worldwide. However, the detail mechanisms and special biomarkers of atherosclerosis remain to be further investigated. Lately, long non-coding RNAs (lncRNAs) has attracted much more attention than other types of ncRNAs. Read More

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http://dx.doi.org/10.3389/fgene.2019.00123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403132PMC
February 2019

Bochdalek hernias in children with late presentation.

Turk Pediatri Ars 2018 Dec 1;53(4):245-249. Epub 2018 Dec 1.

Department of Pediatric Surgery, Fırat University School of Medicine, Elazığ, Turkey.

Aim: Bochdalek hernias, which brought after the neonatal period, are also late-defined cases. In this study, we aimed to present the clinical characteristics of patients with late-presentation Bochdalek hernias who underwent surgery in a reference hospital and our experience regarding their diagnosis.

Material And Methods: Patients with late-presentation Bochdalek hernia who underwent surgery in our clinic between 2001 and 2016 were analyzed retrospectively in terms of the causes of the delay in diagnosis, symptoms, and radiologic and surgical results. Read More

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http://dx.doi.org/10.5152/TurkPediatriArs.2018.0039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408192PMC
December 2018

Predictors of Initial Smear-Negative Active Pulmonary Tuberculosis with Acute Early Stage Lung Injury by High-Resolution Computed Tomography and Clinical Manifestations: An Auxiliary Model in Critical Patients.

Authors:
Jun-Jun Yeh

Sci Rep 2019 Mar 14;9(1):4527. Epub 2019 Mar 14.

Department of Pulmonary Medicine, Section of Thoracic Imaging, and Family Medicine, Ditmanson Medical Foundation, Chia-Yi Christian Hospital, Chiayi, Taiwan.

This study evaluated the diagnostic use of high-resolution computed tomography (HRCT), chest X-ray (CXR), and clinical manifestations (CM) to identify initial smear-negative (iSN) active pulmonary tuberculosis (aPTB) [iSN-aPTB] in patients with iSN-pulmonary diseases (PD) and acute lung injury (ALI). In the derivation cohort, the [iSN-PD] with ALI patients were divided into the [iSN-aPTB] (G1, n = 26) and [non-aPTB-PD] (G2, n = 233) groups. Lung morphology, number, and lobar (segmental) distribution were evaluated using CXR and HRCT. Read More

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http://dx.doi.org/10.1038/s41598-019-40799-wDOI Listing

Dynamic mitochondrial responses to a high-fat diet in Drosophila melanogaster.

Sci Rep 2019 Mar 14;9(1):4531. Epub 2019 Mar 14.

Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, E1A 3E9, Canada.

Mitochondria can utilize different fuels according to physiological and nutritional conditions to promote cellular homeostasis. However, during nutrient overload metabolic inflexibility can occur, resulting in mitochondrial dysfunctions. High-fat diets (HFDs) are usually used to mimic this metabolic inflexibility in different animal models. Read More

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http://dx.doi.org/10.1038/s41598-018-36060-5DOI Listing

Obesity hypoventilation syndrome.

Eur Respir Rev 2019 Mar 14;28(151). Epub 2019 Mar 14.

CIBER de enfermedades respiratorias (CIBERES), Madrid, Spain.

Obesity hypoventilation syndrome (OHS) is defined as a combination of obesity (body mass index ≥30 kg·m), daytime hypercapnia (arterial carbon dioxide tension ≥45 mmHg) and sleep disordered breathing, after ruling out other disorders that may cause alveolar hypoventilation. OHS prevalence has been estimated to be ∼0.4% of the adult population. Read More

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http://err.ersjournals.com/lookup/doi/10.1183/16000617.0097-
Publisher Site
http://dx.doi.org/10.1183/16000617.0097-2018DOI Listing
March 2019
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Pulmonary rehabilitation, physical activity, respiratory failure and palliative respiratory care.

Thorax 2019 Mar 14. Epub 2019 Mar 14.

Department of Research and Education, CIRO, Horn, The Netherlands.

The CIRO Academy in Horn (the Netherlands) organised a 2-day meeting to present and discuss the studies published in 2017 pertaining to key priority areas of respiratory and critical care medicine. This review summarises studies focussing on pulmonary rehabilitation and exercise training, physical activity, chronic respiratory failure and palliative respiratory care published in 2017. Read More

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http://dx.doi.org/10.1136/thoraxjnl-2018-212044DOI Listing

How should complete lung collapse secondary to primary spontaneous pneumothorax be managed? .

Clin Med (Lond) 2019 Mar;19(2):163-168

Royal Stoke University Hospital, Stoke-on-Trent, UK.

Management of primary spontaneous pneumothorax (PSP) depends on the symptoms and size of lung collapse. The British Thoracic Society recommends needle aspiration (NA) for all PSP requiring intervention, followed by intercostal drain (ICD) if NA fails. We compared the role of NA versus ICD as the first step in PSP with 'complete lung collapse'. Read More

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http://dx.doi.org/10.7861/clinmedicine.19-2-163DOI Listing

Endoscopic Treatment of Thoracic Discitis with Robotic Access: A Case Report Merging Two Cutting-edge Technologies.

World Neurosurg 2019 Mar 11. Epub 2019 Mar 11.

Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address:

Background: Emerging technologies in minimally-invasive spinal surgery include surgical robots for navigation and spinal endoscopy. We applied these technologies in concert to treat a critically ill patient with thoracic discitis.

Case Description: The patient is an 83-year old woman with extensive medical comorbidities. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.036DOI Listing

Value of folate receptor-positive circulating tumour cells in the clinical management of indeterminate lung nodules: A non-invasive biomarker for predicting malignancy and tumour invasiveness.

EBioMedicine 2019 Mar 12. Epub 2019 Mar 12.

Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

Background: Non-invasive lung adenocarcinoma could benefit from limited resection, nonetheless, there is a lack of method to determine preoperative tumour invasiveness. We aimed to investigate whether folate receptor-positive circulating tumour cells (FR-CTCs) in combination with maximum tumour diameter (MTD) determines, before surgery, the invasiveness of small-sized, indeterminate solitary pulmonary nodules (SPNs).

Methods: A total of 382 patients with suspicious lung adenocarcinoma on computed tomography who were expected to undergo lung resection were enrolled in this study at three participating institutes and randomly assigned into training and validation cohorts. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.02.028DOI Listing