298,860 results match your criteria Chest Medicine On-Line[Journal]


Machine learning for automatic identification of thoracoabdominal asynchrony in children.

Pediatr Res 2020 Jul 3. Epub 2020 Jul 3.

Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA.

Background: The current methods for assessment of thoracoabdominal asynchrony (TAA) require offline analysis on the part of physicians (respiratory inductance plethysmography (RIP)) or require experts for interpretation of the data (sleep apnea detection).

Methods: To assess synchrony between the thorax and abdomen, the movements of the two compartments during quiet breathing were measured using pneuRIP. Fifty-one recordings were obtained: 20 were used to train a machine-learning (ML) model with elastic-net regularization, and 31 were used to test the model's performance. Read More

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http://dx.doi.org/10.1038/s41390-020-1032-1DOI Listing

Acute myocardial infarction under-diagnosis and mortality in a Tanzanian emergency department: A prospective observational study.

Am Heart J 2020 Jun 5;226:214-221. Epub 2020 Jun 5.

Duke Global Health Institute, 310 Trent Drive, Durham, NC; Division of Cardiology, Duke University School of Medicine, 2301 Erwin Rd, Durham, NC; Duke Clinical Research Institute, 300 W Morgan St, Durham, NC.

Background: Growing evidence suggests that under-diagnosis of acute myocardial infarction (AMI) may be common in sub-Saharan Africa. Prospective studies of routine AMI screening among patients presenting to emergency departments in sub-Saharan Africa are lacking. Our objective was to determine the prevalence of AMI among patients in a Tanzanian emergency department. Read More

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http://dx.doi.org/10.1016/j.ahj.2020.05.017DOI Listing

Chest-CT findings of COVID-19 in patients with pre-existing malignancies; a pictorial review.

Clin Imaging 2020 Jun 9;67:121-129. Epub 2020 Jun 9.

Keck School of Medicine, University of Southern California (USC), Los Angeles, CA, USA.

As of April 17th, 2020, more than 2,190,010 COVID-19 cases with 147,010 deaths have been recorded worldwide. It has been suggested that a high mortality rate occurs in patients with severe disease and is associated with advanced age and underlying comorbidities, such as malignancies. To the best of our knowledge, no study has been conducted to evaluate chest CT features in patients with malignancy and concomitant COVID-19 infection. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.06.004DOI Listing

Multi-Criteria Decision Analysis to prioritize hospital admission of patients affected by COVID-19 in low-resource settings with hospital-bed shortage.

Int J Infect Dis 2020 Jun 30. Epub 2020 Jun 30.

Infectious Diseases Unit, Department of Diagnostics and Public Health, Verona University Hospital, Verona, Italy. Electronic address:

Objective: To use Multi-Criteria Decision Analysis (MCDA) to determine weights for eleven criteria in order to prioritize COVID-19 non-critical patients for admission to hospital in healthcare settings with limited resources.

Methods: The MCDA was applied in two main steps: specification of criteria for prioritizing COVID-19 patients (and levels within each criterion); and determination of weights for the criteria based on experts' knowledge and experience in managing COVID-19 patients, via an online survey. Criteria were selected based on available COVID-19 evidence with a focus on low- and middle-income countries (LMICs). Read More

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http://dx.doi.org/10.1016/j.ijid.2020.06.082DOI Listing

Common and rare susceptibility genetic variants predisposing to Brugada Syndrome in Thailand.

Heart Rhythm 2020 Jun 30. Epub 2020 Jun 30.

Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Pacific Rim Electrophysiology Research Institute, Bumrungrad Hospital, Bangkok, Thailand.

Background: Mutations in SCN5A are rarely found in Thai patients with Brugada syndrome (BrS). Recent evidence suggested that common genetic variation may underlie BrS in a complex inheritance model.

Objective: To find common and rare/low frequency genetic variants predisposing to BrS in Thailand. Read More

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http://dx.doi.org/10.1016/j.hrthm.2020.06.027DOI Listing

Specific gyrA gene mutations correlate with high prevalence of discordant levofloxacin resistance in Mycobacterium tuberculosis isolates from Beijing, China.

J Mol Diagn 2020 Jun 30. Epub 2020 Jun 30.

National Clinical Laboratory on Tuberculosis, Beijing Key laboratory on Drug-resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China. Electronic address:

Although rapid, highly sensitive molecular diagnostics tests are useful for diagnosing fluoroquinolone (FQ)-resistant tuberculosis (TB), results of molecular testing versus conventional sequential phenotypic drug susceptibility testing (pDST) are frequently discordant. Here we determined the discordance rate of levofloxacin (LFX) resistance results obtained via MeltPro TB molecular testing versus pDST of clinical TB isolates collected in Beijing, China between January and December 2018. Isolates with discordant results were further subjected to LFX minimal inhibitory concentration (MIC) determinations and DNA sequence analysis to explore causes of discordance. Read More

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http://dx.doi.org/10.1016/j.jmoldx.2020.06.010DOI Listing

First report of a trifecta bioprosthesis sudden onset three leaflet detachment.

Ann Thorac Surg 2020 Jun 30. Epub 2020 Jun 30.

Cardiac Surgery Department, Hospital Universitario Moncloa. Madrid, Spain.

Acute bioprosthesis failure is an uncommon event that may require urgent surgery. This is even less frequent when it is not associated to endocarditis, thombus formation or structural valve deterioration. We describe for the first time an acute complete detachment of the three leaflets of a Trifecta tissue valve six years after the implantation, in a patient who suddenly suffered a strong chest pain with acute dyspnea. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.05.065DOI Listing

Tongmai Yangxin pill reduces myocardial no-reflow by regulating apoptosis and activating PI3K/Akt/eNOS pathway.

J Ethnopharmacol 2020 Jun 30:113069. Epub 2020 Jun 30.

Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. Electronic address:

Ethnopharmacological Relevance: Tongmai Yangxin pill (TMYX) is derived from the Zhigancao decoction recorded in Shang han lun by Zhang Zhongjing during the Han dynasty and was further improved by Professor Ruan Shiyi, a cardiovascular expert at Tianjin University of Traditional Chinese Medicine. TMYX is used for the clinical treatment of chest pain, heartache, and qi-yin-deficiency coronary heart disease and can improve vascular endothelial function in patients with angina pectoris or coronary heart disease by up-regulating nitric oxide activity and then regulating vascular tension. Whether TMYX can further improve myocardial no-reflow by up-regulating NO activity and then dilating blood vessels remains unclear. Read More

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http://dx.doi.org/10.1016/j.jep.2020.113069DOI Listing

Enhanced Drug and Device Development by Targeting "Relief of Dyspnea".

Chest 2020 Jun 30. Epub 2020 Jun 30.

Jacobs School of Medicine, University at Buffalo, State University of New York, Buffalo, NY.

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http://dx.doi.org/10.1016/j.chest.2020.04.040DOI Listing

Classification of the COVID-19 infected patients using DenseNet201 based deep transfer learning.

J Biomol Struct Dyn 2020 Jul 3:1-8. Epub 2020 Jul 3.

Department of Computer and Communication Engineering, School of Computing and Information Technology, Manipal University Jaipur, Jaipur, India.

Deep learning models are widely used in the automatic analysis of radiological images. These techniques can train the weights of networks on large datasets as well as fine tuning the weights of pre-trained networks on small datasets. Due to the small COVID-19 dataset available, the pre-trained neural networks can be used for diagnosis of coronavirus. Read More

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http://dx.doi.org/10.1080/07391102.2020.1788642DOI Listing

Pediatric Hypersensitivity Pneumonitis: Clinicopathologic Characteristics of Two Cases with Fungal Triggers.

Fetal Pediatr Pathol 2020 Jul 3:1-8. Epub 2020 Jul 3.

Department of Pathology, University of Florida College of Medicine, Gainesville, FL, USA.

Hypersensitivity pneumonitis (HP) infrequently presents in childhood. Asthma or a pneumonia-like clinical presentation may lead to diagnostic delay, especially in children. We present two cases of HP, a 6-year-old (Case 1) male and a 5-year-old (Case 2) female. Read More

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http://dx.doi.org/10.1080/15513815.2020.1786201DOI Listing

Simultaneous pectus excavatum correction and lung transplantation - a case series.

Am J Transplant 2020 Jul 3. Epub 2020 Jul 3.

Division of Thoracic surgery, Medical University of Vienna, Austria.

Severe chest wall deformities are considered an absolute contraindication for lung transplantation. The significantly impaired chest compliance associated with pectus excavatum is thought to result in a high risk of postoperative respiratory complications and significant morbidity and mortality. We herein report our pooled institutional experience consisting of three patients who underwent bilateral lung transplantation and simultaneous correction of a pectus excavatum. Read More

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http://dx.doi.org/10.1111/ajt.16180DOI Listing

Early Comprehensive Testing for COVID-19 is Essential to Protect Trauma Centers.

J Trauma Acute Care Surg 2020 Jun 29. Epub 2020 Jun 29.

Division of Acute Care Surgery, Department of Surgery, University of Alabama at Birmingham.

Background: The SARS-CoV-2 pandemic presents a threat to healthcare systems worldwide. Trauma centers may be uniquely impacted, given the need for rapid invasive interventions in severely injured and the growing incidence of community infection. We discuss the impact that SARS-CoV-2 has had in our trauma center and our steps to limit the potential exposures. Read More

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http://dx.doi.org/10.1097/TA.0000000000002870DOI Listing

GABA-B Receptor Encephalitis Triggered by Enterovirus Encephalitis in a Patient With Small Cell Lung Cancer: A Case Report.

Neurologist 2020 Jul;25(4):106-108

Department of Neurology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Introduction: Encephalitis with gamma-aminobutyric acid (GABA)-B receptor antibodies (GABA-B receptor encephalitis) is known to have underlying neoplastic condition in half of the cases; however, there could be an additional event that could work as a trigger factor. Here, we report a patient with GABA-B receptor encephalitis associated with small cell lung cancer, which was probably triggered by enterovirus encephalitis.

Case Report: A 53-year-old man was admitted for a seizure, following fever and headache for 3 days. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000283DOI Listing

Tocilizumab and Remdesivir in a Pregnant Patient With Coronavirus Disease 2019 (COVID-19).

Obstet Gynecol 2020 Jun 30. Epub 2020 Jun 30.

Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, the Division of Infectious Disease, Department of Internal Medicine, and the Department of Internal Medicine, Cedars Sinai Medical Center, Los Angeles, California.

Background: There are limited data regarding treatment options for pregnant women with severe coronavirus disease 2019 (COVID-19).

Case: A 35-year-old primigravid patient at 22 weeks of gestation presented with 7 days of fever, cough, anosmia, and dyspnea. Nasopharyngeal swab was positive for the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and a chest X-ray demonstrated bilateral patchy infiltrates. Read More

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http://dx.doi.org/10.1097/AOG.0000000000004050DOI Listing

The new era of chest pain evaluation in the Netherlands.

Eur J Emerg Med 2020 Aug;27(4):243-244

Department of Cardiology, Leiden University Medical Centre, Leiden, Zuid-Holland, Netherlands.

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http://dx.doi.org/10.1097/MEJ.0000000000000711DOI Listing

Looking for a better chest pain network: are we really going for it or just chasing shadows?

Eur J Emerg Med 2020 Aug;27(4):241-242

Servicio de Urgencias, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

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http://dx.doi.org/10.1097/MEJ.0000000000000684DOI Listing

Pediatric Resuscitation Practices During the Coronavirus Disease 2019 Pandemic.

Pediatr Crit Care Med 2020 Jun 30. Epub 2020 Jun 30.

Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

Objectives: While most pediatric coronavirus disease 2019 cases are not life threatening, some children have severe disease requiring emergent resuscitative interventions. Resuscitation events present risks to healthcare provider safety and the potential for compromised patient care. Current resuscitation practices and policies for children with suspected/confirmed coronavirus disease 2019 are unknown. Read More

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http://dx.doi.org/10.1097/PCC.0000000000002512DOI Listing

Plexiform Myofibroblastoma: Clinicopathologic Analysis of 36 Cases of a Distinctive Benign Tumor of Soft Tissue Affecting Mainly Children and Young Adults.

Am J Surg Pathol 2020 Jun 30. Epub 2020 Jun 30.

Department of Pathology, Brigham and Women's Hospital.

The spectrum of benign superficial fibroblastic/myofibroblastic tumors continues to expand and includes entities such as plexiform fibrohistiocytic tumor, dermatomyofibroma and fibroblastic connective tissue nevus. Here, we describe a seemingly distinctive group of lesions which we have labeled "plexiform myofibroblastoma" (PM). PM is a rare superficial mesenchymal tumor of fibroblastic/myofibroblastic lineage that predominantly occurs in children and young adults. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001534DOI Listing

Off-pump ascending aorta or aortic arch to descending aorta bypass with a pericardial roll for the treatment of critically ill infants with interrupted aortic arch.

Cardiol Young 2020 Jun 18:1-8. Epub 2020 Jun 18.

Department of Cardiovascular Surgery, Istanbul Medipol University Medical Faculty, Istanbul, Turkey.

Aim: Standard surgical treatment of the interrupted aortic arch with the use of cardiopulmonary bypass is risky especially in critically ill babies. In this manuscript, we present the results of off-pump pericardial roll bypass for the treatment of aortic interruption.

Material And Methods: The technique was applied in nine critically ill infants between July 2011 and December 2019. Read More

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http://dx.doi.org/10.1017/S1047951120001687DOI Listing

Feasibility, Reproducibility, and Clinical Validity of a Quantitative Chest X-Ray Assessment for COVID-19.

Am J Trop Med Hyg 2020 Jul 2. Epub 2020 Jul 2.

Department of Radiology, ASST Fatebenefratelli Sacco, Milan, Italy.

Chest X-ray (CXR) is an essential first-line tool in COVID-19 pneumonia diagnosis and management. Our study aimed at assessing 1) CXR manifestations, frequency, and distribution; 2) the feasibility and repeatability of a CXR severity score; and 3) the correlation between the CXR severity score and clinical and laboratory parameters. We reviewed baseline CXRs and clinical data of consecutive patients who presented to our emergency department and resulted positive at SARS-CoV-2 reverse transcriptase-PCR oropharyngeal swab test from March 1, 2020 to April 6, 2020. Read More

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http://dx.doi.org/10.4269/ajtmh.20-0535DOI Listing

Predictors of Loss to Follow-Up among Men with Tuberculosis in Puducherry and Tamil Nadu, India.

Am J Trop Med Hyg 2020 Jul 6. Epub 2020 Jul 6.

Department of Medicine, Section of Infectious Diseases, Boston University School of Medicine, Boston, Massachusetts.

Identifying predictors of loss to follow-up (LTFU; treatment lapse ≥ 2 months) among people with tuberculosis (TB) may assist programmatic efforts in controlling the spread of TB. Newly diagnosed smear-positive TB patients were enrolled in the Regional Prospective Observational Research for TB study in Puducherry and Tamil Nadu, India. Treatment records were used to identify LTFU of those who were enrolled from May 2014 through December 2017. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0415DOI Listing

Modification of the HEART pathway by adding coronary computed tomography angiography for patients suspected of acute coronary syndrome in the emergency department.

Intern Emerg Med 2020 Jul 2. Epub 2020 Jul 2.

Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.

The HEART (history, ECG, age, risk factors, troponin) pathway (HP) was developed for identifying low-risk patients for early discharge among patients presenting with chest pain to the emergency department (ED). We investigated whether adding coronary computed tomography angiography (CCTA) results to selected patients could improve the diagnostic accuracy of the HP. Patients suspected of acute coronary syndrome who had undergone CCTA were included. Read More

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http://dx.doi.org/10.1007/s11739-020-02419-8DOI Listing

Spontaneous pneumothorax associated with cavitating pulmonary metastasis from breast cancer: a case report and literature review.

Gen Thorac Cardiovasc Surg 2020 Jul 2. Epub 2020 Jul 2.

Division of Pathology, Saiseikai Fukuoka General Hospital, 1-3-46 Tenjin, Chuo-ku, Fukuoka, 810-0001, Japan.

We report a 69-year-old woman with spontaneous pneumothorax associated with cavitating pulmonary metastasis from breast cancer. She was treated for right breast cancer (invasive ductal carcinoma, ypT4bN1M0, stage IIIB) 2 years earlier, and was admitted for right pneumothorax and chest computed tomography, which showed multiple small cavitating lesions in bilateral lungs. The pneumothorax was treated conservatively with chest drainage, but subsequently recurred ipsilaterally. Read More

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http://dx.doi.org/10.1007/s11748-020-01423-1DOI Listing

Nodular distribution pattern on chest computed tomography (CT) in patients diagnosed with nontuberculous mycobacteria (NTM) infections.

Wien Klin Wochenschr 2020 Jul 2. Epub 2020 Jul 2.

Emergency Department of Zagreb County, Matice Hrvatske, Zagreb, Croatia.

Background: This study evaluated the prevalence of spreading pathways in nontuberculous mycobacteria (NTM) pulmonary infections according to nodular distribution patterns seen on chest computed tomography (CT).

Methods: This study included 63 patients diagnosed with NTM lung infections who underwent CT at our institution. A retrospective analysis of CT images focused on the presence and distribution of nodules, presence of intrathoracic lymphadenopathy and the predominant side of infection in the lungs. Read More

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http://dx.doi.org/10.1007/s00508-020-01701-1DOI Listing

A deep learning approach to characterize 2019 coronavirus disease (COVID-19) pneumonia in chest CT images.

Eur Radiol 2020 Jul 2. Epub 2020 Jul 2.

Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, Jiangsu, China.

Objectives: To utilize a deep learning model for automatic detection of abnormalities in chest CT images from COVID-19 patients and compare its quantitative determination performance with radiological residents.

Methods: A deep learning algorithm consisted of lesion detection, segmentation, and location was trained and validated in 14,435 participants with chest CT images and definite pathogen diagnosis. The algorithm was tested in a non-overlapping dataset of 96 confirmed COVID-19 patients in three hospitals across China during the outbreak. Read More

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http://dx.doi.org/10.1007/s00330-020-07044-9DOI Listing

Thoracoscopic repair of congenital diaphragmatic hernia: a new anatomical reconstructive concept for tension dispersal at primary closure.

Surg Endosc 2020 Jul 2. Epub 2020 Jul 2.

Tanta University Hospital, Tanta, Egypt.

Background: Several measures were implemented among authors striving to tail off recurrence rates of thoracoscopic congenital diaphragmatic hernia repair. In the presented study, we extended the use of rib-anchoring stitches to reorient the diaphragmatic muscle leaflets in the types B&C diaphragmatic hernias, to achieve tension dispersal at primary thoracoscopic repair.

Patients And Methods: Included in this study were early and late-onset lateral congenital diaphragmatic hernia patients, who had been operated upon in the years 2012 through 2018. Read More

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http://dx.doi.org/10.1007/s00464-020-07764-5DOI Listing

Robotic-assisted single-incision gastric mobilization for minimally invasive oesophagectomy for oesophageal cancer: preliminary results.

Eur J Cardiothorac Surg 2020 Jul 2. Epub 2020 Jul 2.

Division of Thoracic Surgery, Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Objectives: With the gradual acceptance of robotic-assisted surgery to treat oesophageal cancer and the application of a single-port approach in several abdominal procedures, we adopted a single-port technique in robotic-assisted minimally invasive oesophagectomy during the abdominal phase for gastric mobilization and abdominal lymph node dissection.

Methods: Robotic-assisted oesophagectomy and mediastinal lymph node dissection in the chest were followed by robotic-assisted gastric mobilization and conduit creation with abdominal lymph node dissection, which were performed via a periumbilicus single incision. The oesophagogastrostomy was accomplished either in the chest (Ivor Lewis procedure) or neck (McKeown procedure) depending on the status of the proximal resection margin. Read More

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http://dx.doi.org/10.1093/ejcts/ezaa212DOI Listing

Urology Individual Critical Task List: Creation and Validation of a Simulation Curriculum.

Mil Med 2020 Jul 3. Epub 2020 Jul 3.

Department of Surgery, Madigan Army Medical Center, 9040 Jackson Avenue, Tacoma, WA 98431.

Introduction: Individual critical task lists (ICTLs) are skills identified by the U.S. Army for the maintenance of combat readiness in each military occupational specialty, including physicians. Read More

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http://dx.doi.org/10.1093/milmed/usaa132DOI Listing

The electrocardiographic 'triangular QRS-ST-T waveform' pattern: a marker of severe haemodynamic compromise in Takotsubo syndrome-a case report.

Eur Heart J Case Rep 2020 Jun 25;4(3):1-6. Epub 2020 Apr 25.

Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.

Background: Takotsubo cardiomyopathy is characterized by transient regional systolic dysfunction of the left ventricle, mimicking myocardial infarction. Although systolic left ventricular (LV) function normalizes in most cases, the outcome is not always favourable. Recently, a rare electrocardiogram (ECG) finding, lambda wave ST elevation or 'triangular QRS-ST-T waveform', was suggested as a possible marker of poor outcome in Takotsubo patients. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319850PMC

An incidental finding of a bicuspid aortic valve and pseudocoarctation of the descending aorta in a patient presenting with an acute coronary syndrome: a case report.

Eur Heart J Case Rep 2020 Jun 15;4(3):1-5. Epub 2020 May 15.

Department of Cardiology, University and Hospital of Fribourg, Chemin des Pensionnats 2, 1708 Fribourg, Switzerland.

Background: Aortic pseudocoarctation (PsCoA) is an elongation of the supra-isthmic aorta with kinking and low-grade narrowing. Consequently, no collateral circulation is found. It is frequently associated with other congenital heart anomalies, such as bicuspid aortic valve (BAV). Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319839PMC

False-positive troponin elevation due to an immunoglobulin-G-cardiac troponin T complex: a case report.

Eur Heart J Case Rep 2020 Jun 3;4(3):1-5. Epub 2020 May 3.

Department of Cardiology, St George's University Hospital, Blackshaw Road, London SW17 0QT, UK.

Background: Troponin is a crucial biomarker for the diagnosis of an acute coronary syndrome (ACS). It rises in response to myocardial injury from significant acute myocardial ischaemia caused by obstructive coronary artery disease ['classical' myocardial infarction (MI)]. However, raised levels have also been noted in conditions not recognized as classical ACS. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319834PMC

A case report of an iatrogenic coronary cameral fistula treated by retrograde percutaneous coronary intervention.

Eur Heart J Case Rep 2020 Jun 3;4(3):1-6. Epub 2020 May 3.

Department of Cardiology, Rangueil Hospital, 1 Avenue du Professeur Jean Poulhès, 31400 Toulouse, France.

Background: Acquired coronary cameral fistula is an extremely rare condition that involves an abnormal communication between a coronary artery and a cardiac chamber. It usually occurs after chest trauma or cardiovascular interventions, such as percutaneous coronary intervention (PCI) and is associated with various outcomes, ranging from a stable status to haemodynamic instability. Acquired coronary cameral fistula frequently arises from the right coronary artery and drains generally into the right ventricle. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319832PMC

Delineating anatomy and function with multimodality imaging: a case report of giant right coronary artery aneurysms.

Eur Heart J Case Rep 2020 Jun 24;4(3):1-5. Epub 2020 Apr 24.

Division of Cardiology, Department of Cardiology, John H. Stroger, Jr. Hospital of Cook County, 1901 W. Harrison Street, Room 3620, Chicago, IL 60612, USA.

Background: Giant coronary artery aneurysms (CAAs) are rare and have been reported in patients with connective tissue diseases, arteritides, and atherosclerosis. Given the rarity of the condition, multimodality imaging is essential for comprehensive evaluation of coronary aneurysms and determination of their haemodynamic significance.

Case Summary: A 58-year-old Filipino female was evaluated for dyspnoea on exertion of one month. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319827PMC

What is the mechanism of irregular pacing spikes? Pacing failure, sensing failure, or something else? A case report.

Eur Heart J Case Rep 2020 Jun 4;4(3):1-4. Epub 2020 Apr 4.

Department of Cardiovascular Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan.

Background: In cardiac implantable electronic device management, confused electrocardiograms are sometimes encountered.

Case Summary: We experienced a case of dizziness and presyncope, which was accompanied by irregular pacing spikes following QRS complexes, pacing failure, sensing failure, or something else. The patient's second active pacemaker in her left chest was functioning normally. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319825PMC

A case report of a coronary myocardial bridge with impaired full-cycle ratio during dobutamine challenge.

Eur Heart J Case Rep 2020 Jun 3;4(3):1-4. Epub 2020 May 3.

Division of Cardiology, Department of Medicine, New York-Presbyterian Hospital/Columbia University Irving Medical Center, 161 Fort Washington Ave, New York, NY 10032, USA.

Background: A myocardial bridge (MB) is a coronary variant in which an epicardial coronary artery tunnels through the myocardial band. Although MBs have been reported to cause ischaemia, physiological assessment of an MB has not been fully established.

Case Summary: We encountered a case with exertional chest pain who underwent coronary angiography showing an MB at the mid-left anterior descending artery with systolic compression. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319821PMC

Chest pain without obstructive coronary artery disease: a case series.

Eur Heart J Case Rep 2020 Jun 24;4(3):1-6. Epub 2020 Apr 24.

West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Agamemnon Street, Glasgow G81 4DY, UK.

Background: Ischaemic heart disease is a leading cause of mortality in women. Even in those without obstructive coronary artery disease (CAD), women with angina continue to have increased mortality. There are gender differences in prevalence of different pathophysiologies, including functional disorders such as microvascular and vasospastic angina. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319819PMC

Methylephedrine-induced heart failure in a habitual user of paediatric cough syrup: a case report.

Eur Heart J Case Rep 2020 Jun 27;4(3):1-4. Epub 2020 Apr 27.

Department of Cardiology, Pulmonology, Hypertension, and Nephrology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan.

Background: For relief of cold symptoms, methylephedrine is considered to be safer than ephedrine, particularly when used at the predetermined dose. It is often present in various over-the-counter (OTC) drugs for cold, including paediatric cough syrups.

Case Summary: A 52-year-old man presented with worsening dyspnoea and anorexia for 2 weeks. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319816PMC

Late atrioventricular groove disruption presenting 7 years after mitral valve replacement: a case report.

Eur Heart J Case Rep 2020 Jun 1;4(3):1-5. Epub 2020 May 1.

Department of Cardiovascular Surgery, Hospital das Clínicas, Universidade Federal de Minas Gerais, Avenida Professor Alfredo Balena n 110, Belo Horizonte MG 30.130-100, Brazil.

Background: Left ventricular rupture is the most feared complication in mitral valve surgery. Despite its low incidence, mortality rates can reach up to 75%. It usually presents on the operating room with a dissecting haematoma followed by massive bleeding after discontinuing cardiopulmomary bypass. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319809PMC

Cardiac tamponade due to primary hypothyroidism: acute management and approach to prevent recurrence-a case report.

Eur Heart J Case Rep 2020 Jun 3;4(3):1-5. Epub 2020 May 3.

Department of Cardiology, Osmania General Hospital, Hyderabad, Telangana, India.

Background: Hypothyroidism is a common endocrine disorder resulting from deficiency of thyroid hormone, with iodine deficiency remains the foremost cause. It is more common in women with increasing incidence in the elderly. The manifestations of hypothyroidism results from the hypometabolism in the body at cellular level and affects all organs. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319808PMC

Clinical efficacy and safety of palliative esophageal stenting without fluoroscopy: a systematic review and meta-analysis.

Endosc Int Open 2020 Jul 16;8(7):E944-E952. Epub 2020 Jun 16.

Gastroenterology & Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States.

Despite advances in curative treatments for esophageal cancer, many patients often present with advanced disease. Dysphagia resulting in significant weight loss and malnutrition leads to poor quality of life. Palliative esophageal stenting with self-expanding metal stents (SEMS) helps alleviate symptoms and prolongs survival. Read More

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http://dx.doi.org/10.1055/a-1164-6398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297607PMC

Diagnostic Value of Chest X-Ray in Patients With Suspected Infection and No Respiratory Signs or Symptoms.

Open Forum Infect Dis 2020 Jun 8;7(6):ofaa221. Epub 2020 Jun 8.

Department of Internal Medicine, Flevoziekenhuis, Almere, the Netherlands.

Suspicion of an infection without localizing signs or symptoms is a common problem. A chest x-ray (CXR) is often performed to rule out pneumonia. Our prospective cross-sectional study suggests that a CXR has no diagnostic value in patients without respiratory signs or symptoms, if a reliable medical history can be obtained. Read More

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http://dx.doi.org/10.1093/ofid/ofaa221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314582PMC

Beyond finding druggable targets and tumor mutational burden: to measure heterogeneity by ctDNA.

Ann Transl Med 2020 Jun;8(11):723

Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.

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http://dx.doi.org/10.21037/atm.2020.01.86DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327335PMC

High-level gain of mesenchymal-epithelial transition factor (MET) copy number using next-generation sequencing as a predictive biomarker for MET inhibitor efficacy.

Ann Transl Med 2020 Jun;8(11):685

Department of Oncology, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.

Background: In clinical oncology, targeted next-generation sequencing (NGS) has become an integral part of the routine molecular diagnostics repertoire. However, a consensus is yet to be agreed on the optimal mesenchymal-epithelial transition factor () copy number (CN) cut-off value based on NGS data that could predict the MET-amplified non-small cell lung cancer (NSCLC) patients who could benefit from tyrosine kinase inhibitor (TKI) therapy. In this study, we aimed to identify the criteria to define amplification derived from NGS data. Read More

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http://dx.doi.org/10.21037/atm-20-2741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327325PMC

Coronavirus disease 2019 (COVID-19): chest CT characteristics benefit to early disease recognition and patient classification-a single center experience.

Ann Transl Med 2020 Jun;8(11):679

Department of Radiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: The current outbreak of coronavirus disease 2019 (COVID-19), epi-centered in Wuhan, Hubei Province of the China, has become a global health emergency. Several studies from China have recently provided the evidence of epidemiological, clinical, laboratory, and outcomes of COVID-19 patients. Investigation on the role of chest CT in patient screening and management course in a large cohort remains paucity. Read More

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http://dx.doi.org/10.21037/atm-20-2119aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327362PMC

An Extremely Rare Case of Anomalous Left Main Coronary Artery Originating From Single Right Coronary Ostium Managed Using Heart Team Approach.

Cureus 2020 Jun 28;12(6):e8879. Epub 2020 Jun 28.

Cardiology, Erlanger Health System/University of Tennessee College of Medicine, Chattanooga, USA.

Anomalies of coronary artery origin are rare, difficult to diagnose using conventional testing methods and extremely challenging to eventually manage once diagnosed. The risk of adverse outcomes increases as such patients age and develop atherosclerosis in such vessels. A comprehensive and multidisciplinary approach may be required to best manage such difficult cases. Read More

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http://dx.doi.org/10.7759/cureus.8879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325340PMC

Bronchogenic Cyst Presenting as Acute Pericarditis.

Cureus 2020 Jun 28;12(6):e8874. Epub 2020 Jun 28.

Cardiology, Mercy Catholic Medical Center, Darby, USA.

Bronchogenic cysts are speculated to arise from abnormal budding of the foregut tissue during embryogenesis. Around 90% of mediastinal bronchogenic cysts are asymptomatic, and a small percentage of them present with chest pain and dyspnea. Pericardial effusion is one of the manifestations described; however, pericarditis has not been widely reported. Read More

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http://dx.doi.org/10.7759/cureus.8874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325378PMC

Multivessel Coronary Artery Fistula Presenting as Coronary Steal Syndrome Leading to Cardiac Arrest.

Cureus 2020 May 30;12(5):e8358. Epub 2020 May 30.

Internal Medicine, Brookdale University Hospital Medical Center, New York, USA.

The coronary steal phenomenon refers to myocardial ischemia caused by the diversion of blood away from normal myocardial circulation. A coronary artery fistula (CAF) is an abnormality of the coronary anatomy characterized by the aberrant termination of a coronary artery or its branches into cardiac chambers or great vessels. Although CAFs are often thought to be asymptomatic, fistulas that diverge a significant amount of blood flow and decrease the normal perfusion of myocardial tissue can cause ischemia and can present with acute coronary syndrome. Read More

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http://dx.doi.org/10.7759/cureus.8358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325350PMC

Outcome at Six Months After Primary Percutaneous Coronary Interventions Performed at a Rural Satellite Center of Sindh Province of Pakistan.

Cureus 2020 May 28;12(5):e8345. Epub 2020 May 28.

Cardiology, National Institute of Cardiovascular Diseases, Karachi, PAK.

Introduction Primary percutaneous coronary intervention (PPCI) is now a well-established treatment of acute ST-elevation myocardial infarction (STEMI). For the first time in Pakistan, various off-site satellite centers are established to perform PPCI 24-hours. Our population mainly resides in the rural area with low literacy rate and poor socioeconomic conditions. Read More

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http://dx.doi.org/10.7759/cureus.8345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325348PMC