Search our Database of Scientific Publications and Authors

I’m looking for a

    33478 results match your criteria Chest[Journal]

    1 OF 670

    Stable state MR-proadrenomedullin is associated with severe exacerbations in COPD.
    Chest 2018 Feb 20. Epub 2018 Feb 20.
    Medical School Twente, Medisch Spectrum Twente, Enschede, The Netherlands.
    Background: Elevated levels of Midrange-proadrenomedullin (MR-proADM) is associated with worse outcome in different diseases among which COPD. The association of stable state MR-proADM with severe exacerbations of COPD requiring hospitalisation (severe AECOPD), or with community acquired pneumonia (CAP) in COPD patients has not been studied yet.

    Aims And Objectives: The aim of this study was to evaluate the association of stable state MR-proADM with severe AECOPD and CAP in COPD patients. Read More

    Clinical Features of Extrapulmonary Sarcoidosis without Lung Involvement.
    Chest 2018 Feb 14. Epub 2018 Feb 14.
    Albany Medical Center, Albany, NY.
    Background: Compared to pulmonary sarcoidosis, sarcoidosis without lung involvement may involve other immunopathologic mechanisms and be associated with other demographic and clinical features.

    Methods: This was a retrospective analysis of clinical data collected in real time on 1,686 patients with biopsy-proven sarcoidosis from two large university sarcoidosis outpatient clinics in the United States. We compared differences in demographics characteristics and clinical presentation between pulmonary and non-pulmonary sarcoidosis (NPS). Read More

    A new, noninvasive method of measuring impaired pulmonary gas exchange in lung disease: an outpatient study.
    Chest 2018 Feb 13. Epub 2018 Feb 13.
    Department of Medicine, University of California San Diego, La Jolla, CA 92093-0623.
    Background: It would be valuable to have a noninvasive method of measuring impaired pulmonary gas exchange in patients with lung disease and so reduce the need for repeated arterial punctures. Here we report the results of using a new test in a group of outpatients attending a pulmonary clinic.

    Methods: Inspired and expired Pand Pare continually measured by small, rapidly responding analyzers. Read More

    A Systematic Review and Meta-Analysis Comparing Pigtail Catheter and Chest Tube as the Initial Treatment for Pneumothorax.
    Chest 2018 Feb 13. Epub 2018 Feb 13.
    Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
    Background: The optimal initial treatment approach for pneumothorax remains controversial. This systemic review and meta-analysis investigated the effectiveness of small-bore pigtail catheter (PC) drainage in comparison with that of large-bore chest tube (LBCT) drainage as the initial treatment approach for all subtypes of pneumothorax.

    Methods: We systematically searched PubMed and Embase for observational studies and randomized controlled trials published up to October 9, 2017, that compared PC and LBCT as the initial treatment for pneumothorax. Read More

    Features of Chronic Obstructive Pulmonary Disease as Predictors of Lung Cancer.
    Chest 2018 Feb 13. Epub 2018 Feb 13.
    Department of Medicine.
    Background: Lung cancer is a leading cause of death and hospitalization for patients with chronic obstructive lung disease, (COPD); a detailed understanding of which clinical features of COPD increase risk is needed.

    Methods: To identify clinical and imaging features of smokers, with and without COPD, that are associated with an increased risk of lung cancer, we performed a nested case-control study of COPDGene subjects with and without lung cancer, age 45-80, who smoked at least 10-pack years. Baseline evaluation included: spirometry, high-resolution chest CT, and respiratory questionnaires. Read More

    Expiratory Flow Limitation during Mechanical Ventilation.
    Chest 2018 Feb 9. Epub 2018 Feb 9.
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada; Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Canada. Electronic address:
    Expiratory flow limitation (EFL) is present when the flow cannot rise despite an increase of the expiratory driving pressure. The mechanisms of EFL are debated but are thought to be related to the collapsibility of small airways. In mechanically ventilated patients, EFL can exist during tidal ventilation, representing an extreme situation where lung volume cannot decrease whatever the expiratory driving forces. Read More

    Clinical and safety outcomes of long-term azithromycin therapy in severe COPD beyond the first year of treatment.
    Chest 2018 Feb 7. Epub 2018 Feb 7.
    Department of Respiratory Medicine, Hospital de Sabadell, Institut Universitari Parc Taulí-UAB, Sabadell, Spain; CIBER de Enfermedades Respiratorias, CIBERES, Bunyola, Spain.
    Rationale: Exacerbations of COPD (ECOPD) are a major cause of mortality and morbidity. Continuous cyclic azithromycin (CC-A) reduces the exacerbation rate but it is unknown whether it remains effective and safe beyond the first year.

    Methods: Retrospective analysis of severe COPD GOLD D patients with ≥ 4 moderate-severe ECOPD who received CC-A (500mgr three times/week) as add-on therapy. Read More

    Health Services Burden of Undiagnosed and Overdiagnosed COPD.
    Chest 2018 Feb 6. Epub 2018 Feb 6.
    Institute for Clinical Evaluative Sciences, G1 06, 2075 Bayview Avenue, Toronto Ontario, Canada, M4N 3M5; University of Toronto, Toronto, Ontario, Canada, M5R 0A3; The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada, Canada, M5G 1X8. Electronic address:
    Background: Misdiagnosis of chronic obstructive pulmonary disease (COPD) is common. We aimed to quantify the health services burden of undiagnosed and overdiagnosed COPD in a real world, North American population.

    Methods: A population-based cohort study was conducted. Read More

    Predictive Variables for Failure in Administration of Intrapleural tissue plasminogen activator/deoxyribonuclease in Patients With Complicated Parapneumonic Effusions/Empyema.
    Chest 2018 Feb 6. Epub 2018 Feb 6.
    Department of Surgery, Intermountain Medical Center, Murray, UT.
    Background: Combined intrapleural therapy with tissue plasminogen activator (tPA) and deoxyribonuclease (DNase) has been shown to reduce the need for surgical intervention for complicated pleural effusion/empyema (CPE/empyema). For patients in whom tPA/DNase is likely to fail, however, receipt of this therapy may simply delay the inevitable. The goal of this study was to identify risk factors for failure of combined intrapleural therapy. Read More

    How fragile are clinical trial outcomes that support the CHEST clinical practice guidelines for venous thromboembolism?
    Chest 2018 Feb 1. Epub 2018 Feb 1.
    Background: Venous thromboembolism (VTE) remains a health concern for global populations. Clinical practice guidelines are necessary to guide physicians in the prophylaxis and treatment of VTE.

    Methods: Our investigation assessed the robustness of the underlying evidence in 21 randomized controlled trials (RCTs) used to support treatment recommendations in the 2016 CHEST Guideline and Expert Panel Report on Antithrombotic Therapy for VTE Disease. Read More

    Management of Low-risk Pulmonary Embolism (LoPE) Patients without Hospitalization: The LoPE Prospective Management Study.
    Chest 2018 Feb 1. Epub 2018 Feb 1.
    Professor-University of Utah SOM, Chair-Department of Medicine, Intermountain Medical Center, 5121 South Cottonwood Street, Salt Lake City, UT 84107. Electronic address:
    Background: The efficacy and safety of managing patients with low-risk pulmonary embolism (PE) without hospitalization requires objective data from US medical centers. We sought to determine the 90-day composite rate of recurrent symptomatic venous thromboembolism (VTE), major bleeding events, and all-cause mortality among consecutive patients diagnosed with acute low-risk PE managed without inpatient hospitalization; and to measure patient satisfaction.

    Methods: We performed a prospective cohort single-arm management study conducted from January 2013 to October 2016 in five emergency departments. Read More

    Microbiological outcome of interventions against pulmonary MAC disease: A systematic review.
    Chest 2018 Feb 1. Epub 2018 Feb 1.
    German Central Committee Against Tuberculosis, Berlin, Germany.
    Objective: Pulmonary disease (PD) caused by Mycobacterium avium complex (MAC) is increasing worldwide. We conducted a systematic review of studies that include microbiological outcomes to evaluate current macrolide-based treatment regimens.

    Methods: We searched literature published before April 2017 using MEDLINE, Cochrane, and EMBASE databases. Read More

    A 74-Year-Old Man Presenting With Cough, Malaise, and Mediastinal Lymphadenopathy.
    Chest 2018 Feb;153(2):e37-e40
    Division of Pulmonary, Critical Care & Sleep Medicine, University of Tennessee Health Science Center, Memphis, TN.
    Case Presentation: A 74-year-old white male farmer was admitted from his primary care physician's office after he presented with symptoms of cough productive of clear sputum, malaise, weakness, fatigue, and shortness of breath on exertion for 3 weeks. He was an ex-smoker with a history of hypertension, hyperlipidemia, and coronary artery bypass graft surgery. He did not report any chills, night sweats, or fevers during this presentation. Read More

    A 68-Year-Old Man With Chronic Myelogenous Leukemia and a Large Unilateral Pleural Effusion.
    Chest 2018 Feb;153(2):e33-e36
    Respiratory Institute, Cleveland Clinic, Cleveland, OH.
    Case Presentation: A 68-year-old man with chronic myelogenous leukemia presents for evaluation of 2 months of dyspnea with exertion. He denies cough, fever, chest pain, weight gain, orthopnea, and edema. Since diagnosis of chronic myelogenous leukemia 5 years ago, he has been treated with dasatinib, with recent BCR-ABL1 assay showing no detectable disease in the peripheral blood. Read More

    Mounier-Kuhn Syndrome Mimicking Lymphangioleiomyomatosis.
    Chest 2018 Feb;153(2):e19-e23
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
    We present the case of a man with Mounier-Kuhn syndrome (MKS), or tracheobronchomegaly, who was referred to the National Institutes of Health Clinical Research Center because of a potential diagnosis of lymphangioleiomyomatosis (LAM), a rare condition in men. The patient was evaluated using ongoing protocols and provided written informed consent. The case demonstrates the presence of chronic inflammation surrounding the dilated airways and histologic changes of the lung parenchyma with emphysematouslike disruption in areas adjacent to the dilated airways. Read More

    The Impact of Fluctuations in Pack-Year Smoking History in the Electronic Health Record on Lung Cancer Screening Practices.
    Chest 2018 Feb;153(2):575-578
    Division of Pulmonary, Critical Care, and Sleep Medicine, MetroHealth Campus of Case Western Reserve University, Cleveland, OH; Center for Reducing Health Disparities, MetroHealth Campus of Case Western Reserve University, Cleveland, OH.

    Partners in Healing: Postsurgical Outcomes After Family Involvement in Nursing Care.
    Chest 2018 Feb;153(2):572-574
    Pulmonary and Critical Care Division, Intermountain Medical Center, Murray, UT; Department of Medicine, University of Utah, Salt Lake City, UT. Electronic address:

    Giants in Chest Medicine: Professor Nan-shan Zhong, MD.
    Chest 2018 Feb;153(2):300-301
    State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute for Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University and the SinoFrench Research Institute for Immunology, Guangzhou Medical University. Electronic address:

    Radiation Exposure in the Medical ICU: Predictors and Characteristics.
    Chest 2018 Jan 31. Epub 2018 Jan 31.
    Cleveland Clinic Abu Dhabi, Al Maryah Island, Abu Dhabi, United Arab Emirates.
    Background: Patients admitted to the medical ICU (MICU) are often subjected to multiple radiologic studies. We hypothesized that some endure radiation dose exposure (cumulative effective dose [CED]) in excess of annual US federal occupational health standard limits (CED ≥ 50 mSv) and 5-year cumulative limit (CED ≥ 100 mSv). We also evaluated the correlation of CED with Acute Physiology and Chronic Health Evaluation (APACHE) III score and other clinical variables. Read More

    Investigation of Public Perception of Brain Death, Using the Internet.
    Chest 2018 Jan 31. Epub 2018 Jan 31.
    Department of Critical Care, Children's National Health System, Washington, DC; Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC.
    Background: Brain death is a difficult concept for the public to comprehend, resulting in a reliance on alternative resources for clarity. This study aims to understand the public's perception of brain death via analysis of information on the Internet, determine the accuracy of that information, and understand how its perception affects the physician-patient relationship.

    Methods: We conducted a prospective cross-sectional study to evaluate information available to the public about brain death. Read More

    1 OF 670