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Cell 2018 Dec;175(7):1931-1945.e18

Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA; The J. David Gladstone Institutes, San Francisco, CA, USA. Electronic address:

Mosquito-borne flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), are a growing public health concern. Systems-level analysis of how flaviviruses hijack cellular processes through virus-host protein-protein interactions (PPIs) provides information about their replication and pathogenic mechanisms. We used affinity purification-mass spectrometry (AP-MS) to compare flavivirus-host interactions for two viruses (DENV and ZIKV) in two hosts (human and mosquito). Read More

J Comput Chem 2019 Jan;40(2):430-446

Department of Chemistry and Cherry L. Emerson Center for Scientific Computation, Emory University, Atlanta, 30322, Georgia.

Configuration interaction ligand field theory (CI LFT) calculations of the electronic energy levels of ThO were performed by treating the molecular electronic states as Th free-ion levels perturbed by the ligand field of O . Twenty nine experimentally characterized ThO v = 0 energy levels, together with the energy difference between the v = 0 levels of the Y and W states were fitted using a CI LFT model that included Th 7s , 6d7s, 6d , 7s7p, 6d7p, 5f7s, and 7p configurations. Predictions from these calculations were used to provide tentative assignments for 171 out of 250 ThO band heads listed by Gatterer et al. Read More

Molecules 2018 Dec 11;23(12). Epub 2018 Dec 11.

Institute of Food Technology, University of Debrecen, H-4032 Debrecen, Hungary.

Hungarian sour cherries (SC) are excellent source of anthocyanin (concentrations (100⁻300 mg in 100 g fresh fruit) and melatonin (0.15 mg in 100 g fresh fruit), but other flavonoid derivatives also can be isolated by aqueous alcoholic extraction. We have developed a new process for extracting non-extractable procyanidines bound to the membrane, proteins, and fibers. Read More

Melanoma Res 2018 Dec 12. Epub 2018 Dec 12.

Section of Dermatology and Infectious Diseases, Department of Medical Sciences.

The aim of the study was to assess the association between eruptive cherry angiomas (CAs) and malignant melanoma (MM). Secondary objectives included investigating (i) this association in different age subgroups, and (ii) the association of eruptive CAs with other variables such as malignant tumours, in general, and immunosuppressive treatments. This cross-sectional study involved all patients referred to the outpatient Dermatology-Oncology Units of the universities of Ferrara and Bologna, Italy, and submitted to total body skin examination. Read More

Phys Med Biol 2018 Nov 5. Epub 2018 Nov 5.

Department of Biomedical Engineering, University of California - Davis, One Shields Avenue, Davis, California, 95616, UNITED STATES.

The performance of a depth-of-interaction (DOI) encoding PET detector module with dual-ended readout of LYSO scintillator arrays using large-area SiPM arrays was evaluated. Each SiPM array, with a surface area 50.2 mm x 50. Read More

Hum Pathol 2018 Dec 7;82:39-45. Epub 2018 Jul 7.

Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

Undifferentiated malignancies (UMs) encompass a diverse set of aggressive tumors that pose not only a diagnostic challenge but also a challenge for clinical management. Most tumors in this category are currently treated empirically with nonspecific chemotherapeutic agents that yield extremely poor clinical response. Given that UMs are inherently genetically unstable neoplasms with the potential for immune dysregulation and increased neoantigen production, they are likely to be particularly amenable to immune checkpoint inhibitors, which target programmed cell death protein 1 (PD-1) or its ligands, PD-L1 and PD-L2, to promote T-cell antitumor activity. Read More

ACS Infect Dis 2018 Dec 12. Epub 2018 Dec 12.

Hepatitis B virus (HBV) globally affects more than 257 million people, resulting in progressively worsening liver disease, manifesting as fibrosis, cirrhosis and hepatocellular carcinoma. The exceptionally narrow species tropism of HBV restricts its natural hosts to humans and non-human primates, including chimpanzees, gorillas, gibbons, and orangutans. The unavailability of completely immunocompetent small-animal models has contributed to the lack of curative therapeutic interventions. Read More

J Exp Child Psychol 2018 Dec 8;179:162-175. Epub 2018 Dec 8.

School of Psychology, Queen's University Belfast, Belfast BT7 1NN, Northern Ireland, UK.

Children (6- and 7-year-olds) decided whether to wait for a short delay to win a prize or for a longer period to win a different prize. Those who chose to take their prize after a short delay won two candies but were shown that they would have won four candies if they had waited longer. We measured whether children regretted their choice not to wait. Read More

Nucleic Acids Res 2018 Dec 8. Epub 2018 Dec 8.

Microbiol Resour Announc 2018 Oct 25;7(16). Epub 2018 Oct 25.

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.

Here, we report the complete genome sequence of a divergent cherry virus A (CVA) isolate (ChYT56) from Prunus avium in China. The genome nucleotide sequence has low identity (80.7%) with a CVA from P. Read More

Microbiol Resour Announc 2018 Oct 11;7(14). Epub 2018 Oct 11.

Dipartimento di Scienze del Suolo della Pianta e degli Alimenti, Università degli Studi di Bari Aldo Moro, Bari, Italy.

We report the complete annotated genome sequence of the plant-pathogenic bacterium Xylella fastidiosa subsp. strain IVIA5235. This strain was recovered from a cherry tree in Mallorca, Spain. Read More

PLoS One 2018 7;13(12):e0208770. Epub 2018 Dec 7.

Department of Horticulture, Sunchon National University, Suncheon, Republic of Korea.

Tomato, which can be eaten as a vegetable or fruit, is one of the most popular and nutritionally important crops around the world. Although most plants of the cherry tomato cultivar 'Minichal' have a normal phenotype, some plants have a stunted phenotype with reduced plant height, leaf size, and fruit size, as well as altered leaf and fruit shape. To investigate the molecular mechanisms underlying these differences, we generated RNA-seq libraries from pooled leaf samples of 10 normal (N) and 10 stunted (S) plants. Read More

Ergonomics 2018 Dec 8:1-44. Epub 2018 Dec 8.

d School of Psychology , Georgia Institute of Technology , 654 Cherry St. NW , Atlanta , GA 30332.

As coordination mechanisms change and technology failures occur, a sociotechnical system must reorganize itself across human and technological layers to maintain effectiveness. We present a study examining reorganization across communication, controls, and vehicle layers of a remotely-piloted aircraft system (RPAS) using a layered dynamics approach. Team members (pilot; navigator; photographer) performed 5 simulated RPAS missions using different operator configurations, including all-human and human-autonomy teams. Read More

Phys Med Biol 2018 Dec 6;63(23):235031. Epub 2018 Dec 6.

Department of Biomedical Engineering, UC Davis, Davis, California, United States of America. Author to whom any correspondence should be addressed.

Preclinical positron emission tomography, combined with magnetic resonance imaging (PET/MRI), is increasingly used as a tool to simultaneously characterize functional processes in vivo. Many emerging preclinical applications, however, are limited by PET detection sensitivity, especially when generating short imaging frames for quantitative studies. One such application is dynamic multifunctional imaging, which probes multiple aspects of a biological process, using relationships between the datasets to quantify interactions. Read More

Genes Nutr 2018 29;13:29. Epub 2018 Nov 29.

2Human Nutrition Unit, Université Clermont Auvergne, INRA, F63000 Clermont-Ferrand, France.

Fruit is a key component of a healthy diet. However, it is still not clear whether some classes of fruit may be more beneficial than others and whether all individuals whatever their age, gender, health status, genotype, or gut microbiota composition respond in the same way to fruit consumption. Such questions require further observational and intervention studies in which the intake of a specific fruit can be precisely assessed at the population and individual levels. Read More

Food Sci Technol Int 2018 Dec 5:1082013218813823. Epub 2018 Dec 5.

2 Department of Food Science and Technology, Shiraz University, Shiraz, Iran.

The main objectives of this work were to study the survivability of five probiotic lactobacilli strains in sour cherry juice and citrate buffer with similar pH values (pH 3.5) during storage at 4 ℃ as well as to encapsulate the strain with the least survival in calcium alginate beads. Enterococcus faecium from probiotic strains in sour cherry juice exhibited the least survival; therefore, this strain was selected for studying the protective effect of microencapsulation in calcium alginate beads. Read More

Vector Borne Zoonotic Dis 2018 Dec 1. Epub 2018 Dec 1.

4 Division of Vector-Borne Diseases, Centers for Disease Control and Prevention , Fort Collins, Colorado.

Introduction: Tularemia is a zoonotic infection caused by the highly infectious bacterium Francisella tularensis. Persons having outdoor professions are more likely than others to be exposed to F. tularensis through increased contact with arthropods, infected animals, and contaminated aerosols. Read More

PLoS One 2018 3;13(12):e0208103. Epub 2018 Dec 3.

French Associates Institute for Agriculture and Biotechnology of Drylands, Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Sede Boqer Campus, Israel.

Aphids are major pests in cereal crops that cause direct and indirect damage leading to yield reduction. Despite the fact that wheat provides 20% of the world's caloric and protein diet, its metabolic responses to aphid attack, in general, and specifically its production of benzoxazinoid defense compounds are poorly understood. The objective of this study was to compare the metabolic diversity of durum wheat seedlings (Triticum turgidum ssp. Read More

Protoplasma 2018 Nov 30. Epub 2018 Nov 30.

Centro de Investigación y Tecnología Agroalimentaria de Aragón. Instituto Agroalimentario de Aragón - IA2 (CITA), Universidad de Zaragoza, Av. Montañana 930, 50059, Zaragoza, Spain.

Anther and pollen development is a highly conserved process in angiosperms, but while pollen formation in annual plants occurs in a few days, in temperate woody perennials, it requires several months. How anther and pollen development is framed in terms of seasonality plays a clear part in reproductive success. In this study, seasonal anther and pollen development is characterized in two sweet cherry cultivars over 2 years, paying special attention to the period of dormancy and unveiling the role of starch in this process. Read More

Food Chem 2019 Mar 30;277:480-489. Epub 2018 Oct 30.

Food Colour & Quality Lab, Area of Nutrition & Food Science, Universidad de Sevilla, Facultad de Farmacia, 41012 Sevilla, Spain. Electronic address:

The aim of this study was to assess commercial quality parameters, sugars, phenolics, carotenoids and plastid in diverse and little studied tomato varieties to gain insight into their commercial and functional quality and reveal possible noticeable differences. Five cherry tomato varieties and six common (i.e. Read More

Ir J Psychol Med 2018 Dec;35(4):321-324

3Jonathan Swift Clinic,St James's Hospital,James's Street,Dublin 8,Ireland.

Objectives: To compare benzodiazepine and z-hypnotic prescribing practices in an inpatient psychiatric unit to best practice standards.

Methods: Medication charts of all inpatients in the psychiatric unit, over a 1-week period, were reviewed. Details of current benzodiazepine and z-hypnotic prescriptions were collected. Read More

Plant Dis 2018 Dec 3:PDIS05180857RE. Epub 2018 Dec 3.

Department of Ecology & Environmental System, College of Ecology & Environmental Sciences, Kyungpook National University, Sangju-si, Gyeongsangbuk-do, 37224, Korea (Republic of).

Persimmon (Diospyros kaki) fruit production is severely affected by circular leaf spot worldwide. Mycosphaerella nawae causes circular leaf spot of persimmon (CLSP) and can result in leaf spot, defoliation, early fruit maturation, and subsequent softening and abscission. The morphology and phylogenetic position of M. Read More

Nutrients 2018 Dec 3;10(12). Epub 2018 Dec 3.

Population and Behavioral Sciences, School of Medicine, University of St Andrews, St Andrews KY16 9TF, UK.

Large portions of energy dense foods promote overconsumption but offering small portions might lead to compensatory intake of other foods. Offering a variety of vegetables could help promote vegetable intake and offset the effect of reducing the portion size (PS) of a high energy dense (HED) food. Therefore, we tested the effect on intake of reducing the PS of a HED unit lunch item while varying the variety of the accompanying low energy dense (LED) vegetables. Read More

Front Microbiol 2018 19;9:2772. Epub 2018 Nov 19.

College of Animal Science and Technology, Shandong Agricultural University, Tai'an, China.

Hydropericardium hepatitis syndrome (HHS) caused by group I fowl adenovirus serotype 4 (FAdV-4) is an acute and infectious disease in fowl, particularly in broilers aged 3-5 weeks. In June 2015, a highly pathogenic disease outbroke in 25-40 day-old ducklings in Shandong province, characterized similar symptom to HHS. In order to determine the pathogenic mechanism of FAdV-4 (SDSX strain) in meat ducks. Read More

J Therm Biol 2018 Dec 14;78:92-99. Epub 2018 Sep 14.

Department of Entomology, College of Agricultural and Environmental Sciences, University of Georgia, 413 Biological Sciences, Athens, GA 30602-2603, USA. Electronic address:

Drosophila suzukii Matsumura (Diptera: Drosophilidae) is an invasive vinegar fly of Asian origin now distributed throughout North America. Due to the unique morphology of females, this fly has become one of the most serious pests of thin-skinned fruits including blueberry, blackberry, cherry, raspberry, and strawberry. Prophylactic insecticide applications are commonly used to control this fly. Read More

Prev Chronic Dis 2018 Nov 29;15:E146. Epub 2018 Nov 29.

Centers for Disease Control and Prevention, Atlanta, Georgia.

J Appl Physiol (1985) 2018 Nov 29. Epub 2018 Nov 29.

Sport & Health Sciences, Exeter University, United Kingdom.

Flavonoid supplementation improves brachial artery flow-mediated dilatation (FMD), but it is not known whether flavonoids protect against vascular dysfunction induced by ischemia-reperfusion (IR) injury and associated respiratory burst. In a randomized, double-blind, placebo-controlled, crossover study, we investigated whether 4-weeks supplementation with freeze-dried Montmorency cherry (MC) attenuated suppression of FMD after IR induced by prolonged forearm occlusion. Twelve physically inactive middle-aged men (52. Read More

Bioanalysis 2018 Nov 29. Epub 2018 Nov 29.

F Hoffmann-La Roche, Basel, Switzerland.

The 2018 12 Workshop on Recent Issues in Bioanalysis took place in Philadelphia, PA, USA on April 9-13, 2018 with an attendance of over 900 representatives from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract research organizations and regulatory agencies worldwide. WRIB was once again a 5-day, week-long event - a full immersion week of bioanalysis, biomarkers and immunogenicity. As usual, it was specifically designed to facilitate sharing, reviewing, discussing and agreeing on approaches to address the most current issues of interest including both small- and large-molecule bioanalysis involving LCMS, hybrid LBA/LCMS and LBA/cell-based assays approaches. Read More

Bioanalysis 2018 Nov 29. Epub 2018 Nov 29.

Amador Bioscience, Pleasanton, CA, USA (formerly of OncoMed, Redwood City, CA, USA).

The 2018 12 Workshop on Recent Issues in Bioanalysis took place in Philadelphia, PA, USA on April 9-13, 2018 with an attendance of over 900 representatives from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract research organizations and regulatory agencies worldwide. WRIB was once again a 5-day full immersion in bioanalysis, biomarkers and immunogenicity. As usual, it was specifically designed to facilitate sharing, reviewing, discussing and agreeing on approaches to address the most current issues of interest including both small- and large-molecule bioanalysis involving LCMS, hybrid LBA/LCMS and LBA/cell-based assays approaches. Read More

Bioanalysis 2018 Nov 29;10(22):1781-1801. Epub 2018 Nov 29.

UK MHRA, London, UK.

The 2018 12 Workshop on Recent Issues in Bioanalysis (12th WRIB) took place in Philadelphia, PA, USA on April 9-13, 2018 with an attendance of over 900 representatives from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract research organizations and regulatory agencies worldwide. WRIB was once again a 5-day full immersion in bioanalysis, biomarkers and immunogenicity. As usual, it was specifically designed to facilitate sharing, reviewing, discussing and agreeing on approaches to address the most current issues of interest including both small- and large-molecule bioanalysis involving LC-MS, hybrid ligand binding assay (LBA)/LC-MS and LBA/cell-based assays approaches. Read More

Planta 2018 Nov 28. Epub 2018 Nov 28.

School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, UK.

Main Conclusion: ATR-FTIR spectroscopy with subsequent multivariate analysis non-destructively identifies plant-pathogen interactions during disease progression, both directly and indirectly, through alterations in the spectral fingerprint. Plant-environment interactions are essential to understanding crop biology, optimizing crop use, and minimizing loss to ensure food security. Damage-induced pathogen infection of delicate fruit crops such as tomato (Solanum lycopersicum) are therefore important processes related to crop biology and modern horticulture. Read More

Neurocrit Care 2018 Nov 27. Epub 2018 Nov 27.

Epilepsy Center, Hauenstein Neurosciences Mercy Health Saint Mary's, Grand Rapids, MI, USA.

Background: Status, refractory status and super refractory status epilepticus are common neurologic emergencies. The objective of this study is to investigate the feasibility, safety and effectiveness of a ketogenic diet (KD) for refractory status epilepticus (RSE) in adults in the intensive care unit (ICU).

Methods: We performed a retrospective, single-center study of patients between ages 18 and 80 years with RSE treated with a KD treatment algorithm from November 2016 through April 2018. Read More

Int J Food Microbiol 2018 Nov 19;291:91-103. Epub 2018 Nov 19.

Dipartimento Scienze Agrarie, Alimentari e Forestali, Università di Palermo, Viale delle Scienze 4, 90128 Palermo, Italy. Electronic address:

Early vat bacterial biofilms developed spontaneously through contact with whey have been characterized on seven wood types (Castanea sativa Miller, Cedrus libani, A. Rich., Prunus avium L. Read More

Am J Pathol 2018 Nov 22. Epub 2018 Nov 22.

Institute of Medical Science, University of Toronto, Toronto Canada; Department of Pediatrics, Medical College of Wisconsin, Milwaukee USA; Department of Medical Biophysics, University of Toronto, Toronto, Canada; Department of Biochemistry, Medical College of Wisconsin, Milwaukee USA; University Health Network, Toronto, Canada. Electronic address:

Farber Disease (FD) is a debilitating lysosomal storage disorder characterized by severe inflammation and neurodegeneration. FD is caused by mutations in the ASAH1 gene resulting in deficient acid ceramidase (ACDase) activity. Patients with ACDase deficiency exhibit a broad clinical spectrum. Read More

J Cell Physiol 2018 Nov 23. Epub 2018 Nov 23.

Key Laboratory of Animal Genetics and Breeding and Molecular Design of Jiangsu Province, Yangzhou University, Yangzhou, China.

MicroRNA (miRNA)-1 and miRNA-133 are derived from the same bicistronic pairs with roles in skeletal muscle development. Many investigations have focused on the role of miRNA-1 and miRNA-133 in the regulation of skeletal muscle development in mammals and fish. However, the mechanisms of miRNA-1 and miRNA-133 underlying the differences in skeletal muscle development between different breeds are not well known. Read More

J Patient Rep Outcomes 2018 Nov 23;2(1):55. Epub 2018 Nov 23.

Institute for Public Health and Medicine, Hauenstein Neurosciences, Northwestern University, 233 Erie St, Chicago, Il 60611, USA.

Introduction: Depressive symptoms in patients with intracerebral hemorrhage (ICH) are common and are associated with worse outcomes. It is not well described how often depressive symptoms are ascertained and treated in large unselected cohorts of patients, and whether depressive symptoms would be a potential target for improving outcomes.

Methods: Data were electronically retrieved from a multi-center EHR repository in Chicago, IL, from 2006 to 2012 ("multicenter cohort"). Read More

Addict Behav 2018 Nov 15. Epub 2018 Nov 15.

Division of Behavioral Sciences and Community Health, MC3910, UConn Health, Farmington, CT 06030, USA. Electronic address:

Background: The popularity of E-cigarettes is due in part to their flavorings. The purpose of this study was to determine the effect on smokers' sensory perceptions and liking of various e-cigarette flavorings, and the degree to which those perceptions are influenced by nicotine level, sex, and PROP bitter taster phenotype.

Methods: We recruited 132 non-treatment-seeking, daily cigarette smokers. Read More

J Nat Med 2018 Nov 22. Epub 2018 Nov 22.

Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan.

Pruni Cortex is a herbal drug from the bark of the Japanese flowering cherries, Prunus jamasakura or Prunus verecunda, and is included in the traditional Japanese herbal (Kampo) formula Jumihaidokuto, which is administered orally to patients suffering from inflammatory skin diseases. The flavanones contained in Pruni Cortex (e.g. Read More

Nutr Neurosci 2018 Nov 22:1-7. Epub 2018 Nov 22.

a Department of Psychology , Queens College, CUNY , 65-30 Kissena Blvd., Flushing , NY 11367 , USA.

The study of inbred mouse strains is a useful animal model to assess differences in ingestive behavior responses, including conditioned flavor preferences (CFP). C57BL/6, BALB/c and SWR inbred mice display differential sensitivity to dopamine (DA) D1, opioid and muscarinic cholinergic receptor antagonism of sucrose or saccharin intake as well as to muscarinic cholinergic antagonism of acquisition (learning) of sucrose-CFP. Given that DA D1, opioid and N-methyl-D-aspartate (NMDA) receptor antagonists differentially alter sucrose-CFP in BALB/c and SWR inbred mice, the present study examined whether systemic administration of naltrexone, SCH23390 or MK-801 altered acquisition and expression of sucrose-CFP in C57BL/6 mice. Read More

Int J Biometeorol 2018 Nov 20. Epub 2018 Nov 20.

INRA, University Bordeaux, UMR Biologie du Fruit et Pathologie, Villenave d'Ornon, France.

Evaluation of chilling requirements of cultivars of temperate fruit trees provides key information to assess regional suitability, according to winter chill, for both industry expansion and ongoing profitability as climate change progresses. Traditional methods for calculating chilling requirements use climate-controlled chambers and define chilling requirements (CR) using a fixed bud burst percentage, usually close to 50% (CR-50%). However, this CR-50% definition may estimate chilling requirements that lead to flowering percentages that are lower than required for orchards to be commercially viable. Read More

Adv Health Sci Educ Theory Pract 2018 Nov 19. Epub 2018 Nov 19.

Western University, London, Canada.

Learner engagement matters, particularly in simulation-based education. Indeed, it has been argued that instructional design only matters in the service of engaging learners in a simulation encounter. Yet despite its purported importance, our understanding of what engagement is, how to define it, how to measure it, and how to assess it is limited. Read More

Psychoneuroendocrinology 2018 Sep 14;101:111-120. Epub 2018 Sep 14.

School of Psychology, Georgia Institute of Technology, 654 Cherry Street, Atlanta, GA 30332-0170, United states. Electronic address:

We investigated if the relationship between age and regional limbic system brain structure would be moderated by diurnal cortisol output and diurnal cortisol slope. Participants aged 23-83 years collected seven salivary cortisol samples each day for 10 consecutive days and underwent magnetic resonance imaging. Age, sex, cortisol, and an age x cortisol interaction were tested as predictors of hippocampal and amygdalar volume and caudal and rostral anterior cingulate cortex (ACC) thickness. Read More

Pol J Vet Sci 2018 Jun;21(2):389-396

Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, National Center for Engineering Research on Veterinary Bio-products, Nanjing, Jiangsu Province, China.

In order to compare the pathogenicity of different Tembusu virus (TMUV) strains from geese, ducks and chickens, 56 5-day-old Cherry Valley ducklings which were divided into 7 groups and infected intramuscularly with 7´105 PFU/ml per duck of six challenge virus stocks. The clinical signs, weight gain, mortality, macroscopic and microscopic lesions, virus loads in sera of 1, 3, 5, 7, 11 and 14 dpi and serum antibody titers were examined. The results showed that these viruses could make the young ducks sick, but the clinical signs differed with the different species-original strains. Read More

Kidney Int Rep 2018 Nov 29;3(6):1454-1463. Epub 2018 Jul 29.

Center for Pediatrics and Adolescent Medicine, University Hospital Freiburg, Freiburg University, Faculty of Medicine, Freiburg, Germany.

Introduction: Monogenetic renal diseases, including recessively inherited nephrotic syndromes, represent a significant health burden despite being rare conditions. Precise diagnosis, including identification of the underlying molecular cause, is especially difficult in low-income countries and/or if affected individuals are unavailable for biochemical testing. Whole-exome sequencing (WES) has opened up novel diagnostic perspectives for these settings. Read More

J Neuroeng Rehabil 2018 Nov 15;15(1):105. Epub 2018 Nov 15.

Institute of Health and Biomedical Innovation at QLD Centre for Children's Health Research, School of Exercise and Nutrition Sciences, Queensland University of Technology, 62 Graham St, South Brisbane, QLD, 4101, Australia.

Background: Cerebral palsy (CP) is the most common physical disability among children (2.5 to 3.6 cases per 1000 live births). Read More

Oxid Med Cell Longev 2018 23;2018:1841046. Epub 2018 Oct 23.

School of Pharmacy, University of Southern California, 1985 Zonal Ave., Los Angeles, CA 90033, USA.

Aims: The goal of this study was to evaluate the effects of long-term (16 weeks) administration of angiotensin (1-7) [A(1-7)] on kidney function in mice and to identify the protective mechanisms of this therapy.

Methods: mice and heterozygous controls were treated with A(1-7) or vehicle daily, subcutaneously for up to 16 weeks. Kidney injury was assessed by measuring blood flow in renal arteries, plasma creatinine levels, and proteinuria. Read More

Antioxidants (Basel) 2018 Nov 12;7(11). Epub 2018 Nov 12.

Laboratory of Microbiology, Biotechnology and Hygiene, Faculty of Agriculture Development, Democritus University of Thrace, 68200 Orestiada, Greece.

The present study describes the development of a novel functional beverage through the application of probiotic ATCC (American Type Culture Collection) 14917 in Cornelian cherry juice fermentation. The probiotic was employed in free and immobilized in a delignified wheat bran carrier (DWB) form. Cornelian cherry juice was fermented for 24 h and then it was stored at 4 °C for 4 weeks. Read More

Can J Anaesth 2018 Nov 12. Epub 2018 Nov 12.

Department of Anesthesia and Pain Management, Toronto General Hospital, Toronto, ON, Canada.

Purpose: Whether current standards of care management for malignant hyperthermia (MH)-susceptible patients result in acceptable postoperative clinical outcomes at a population level is not known. Our objective was to determine if patients with susceptibility to MH experienced similar outcomes as patients without MH susceptibility after surgery under general anesthesia.

Methods: This was a retrospective, population-based cohort study from 1 April 2009 until 31 March 2016 in the Canadian province of Ontario. Read More

Sci Rep 2018 Nov 12;8(1):16670. Epub 2018 Nov 12.

Rickettsial Zoonoses Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Laboratory testing for Q fever (Coxiella burnetii) is essential for a differential diagnosis, yet little is known about Q fever diagnostic testing practices in the United States. We retrospectively analyzed Q fever immunoglobulin G (IgG) indirect immunofluorescence assay (IFA) testing data between 1/1/2012-10/31/2016 from ARUP, LabCorp, Mayo Medical Laboratories, and Quest Diagnostics. Data included IgG phase I and phase II titers, patient age and sex, and state and date of specimen collection. Read More