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Dermatol Surg 2017 Nov;43(11):1313-1320

*University of Texas McGovern Medical School at Houston, Houston, Texas; †Department of Dermatology, University of Texas McGovern Medical School at Houston, Houston, Texas.

Background: Sodium tetradecyl sulfate (STS) is Food and Drug Administration approved for treatment of varicose veins, but numerous other off-label applications have been reported.

Objective: To describe the clinical uses of STS, as well as efficacy and adverse effects.

Methods: Review of studies searchable on PubMed from 1938 to 2016 describing clinical uses of STS to determine efficacy and adverse effects associated with various applications. Read More

Plast Reconstr Surg 2016 Aug;138(2):410-7

Sacramento and Davis, Calif. From the Department of Surgery, Division of Plastic Surgery, and the Department of Biochemistry and Molecular Medicine, University of California-Davis Medical Center; and the Department of Biomedical Engineering, University of California-Davis.

Background: Current treatments for infantile hemangiomas have unpredictable outcomes. The authors' aim was to develop a nanoporphyrin-delivered, high-efficacy treatment for infantile hemangiomas using a mouse hemangioendothelioma model.

Methods: The authors injected mouse hemangioendothelioma cells intradermally to axillary regions of 5-week-old, female, nude mice (n = 19) to induce hemangioendothelioma growth. Read More

Can Respir J 2016 6;2016:5682904. Epub 2016 Mar 6.

Department of Pathology, Singapore General Hospital, Singapore.

J Drugs Dermatol 2016 Jun;15(6):713-4

Cherry hemangiomas are common vascular proliferative lesions that can be concerning from a cosmetic perspective. Laser therapy is often used to eradicate cherry hemangiomas, but some lesions require multiple treatments or do not resolve at all. The suboptimal response to laser treatment may be due to limitations in penetration depth by vascular lasers such as the pulsed dye laser. Read More

Int J Dermatol 2016 Nov;55(11):e598-e600

Department of Medical Sciences, Section of Dermatology and Infectious Diseases, University of Ferrara, Ferrara, Italy.

Arch Dermatol Res 2016 Jul 8;308(5):373-7. Epub 2016 Apr 8.

Section of Microbiology and Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Human herpesvirus 8 (HHV8) has been hypothesized to be a potential cofactor for the development of diverse cutaneous vascular proliferative lesions, including eruptive cherry angiomas. Recent reports evidenced the influence of killer cell immunoglobulin-like receptor (KIR) gene diversity in defining the susceptibility to symptomatic herpesvirus infections. In this study, skin samples from vascular lesions and healthy controls were characterized simultaneously for the presence of HHV8 and for the KIR genotype, focusing upon the presence of the KIR2DL2/DS2 and KIR2DL3 genes, which have been associated to herpesvirus susceptibility. Read More

MMW Fortschr Med 2014 Nov;156(19):65

Clin Exp Dermatol 2014 Oct;39(7):819-21

Department of Dermatology, Beijing Hospital, Beijing, China.

The dyschromatoses are a group of disorders characterized by the presence of both hyperpigmented and hypopigmented macules, many of which are small in size and irregular in shape. Localized dyschromatosis is a rare manifestation of dyschromatosis. Localized dyschromatosis showing segmental distribution may be a result of degeneration of localized cutaneous nerves. Read More

Dermatol Surg 2014 Sep;40(9):1022-7

Departments of *Dermatology, Venereology, and Leprosy; †Orthopedics, Pt. B.D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, India.

Background: Sclerotherapy is a safe, effective, and easily available treatment modality, its role in cherry hemangioma is still unexplored.

Objective: This study aims at establishing the role and efficacy of sclerotherapy in treating cherry angiomas and its dermatological complications.

Materials And Methods: This prospective study included 20 patients with 100 lesions of cherry hemangiomas of size >0. Read More

Dermatol Ther 2014 Jan-Feb;27(1):52-4. Epub 2013 Apr 10.

Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, China; Department of Dermatology, The People's Hospital of Liaoning Province, Shenyang, China.

Clin Exp Dermatol 2013 Jun 3;38(4):386-9. Epub 2013 Apr 3.

Department of Dermatology and Wound Healing, Institute of Infection and Immunity, Cardiff University, Cardiff, UK.

Cherry angiomas (Campbell de Morgan spots) are common acquired red skin papules composed of dilated capillary loops, usually of unknown aetiology. Extragenital lichen sclerosus (LS) presents as porcelain-white scaly atrophic lesions with or without genital involvement. We report two cases of segmental multiple cherry angiomas in association with extragenital LS. Read More

J Am Acad Dermatol 2013 Apr;68(4):e137-8

JAMA Dermatol 2013 Feb;149(2):204-8

Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.

Background: Eruptive cherry hemangiomatosis, which involves the sudden onset of multiple small vascular proliferations, has been rarely reported as a heralding sign of multicentric Castleman disease (MCD) and other lymphoproliferative diseases. We report a case wherein the rapid appearance of cherry hemangiomata is the presenting sign of MCD.

Observations: A 25-year-old man with a 10-year history of benign vascular growths developed 23 cutaneous vascular proliferations and systemic symptoms 5 days prior to presentation. Read More

Int Immunopharmacol 2013 Nov 29;17(3):991-5. Epub 2013 Jan 29.

Immunoregulation Research Center, Shahed University, Tehran, Islamic Republic of Iran; Department of biology, Faculty of Basic Sciences, Shahid Bahonar University, Kerman, Islamic Republic of Iran.

Exposure to SM leads to short and long term adverse effects on various organs including the skin. Cherry angioma is one of the late skin disorders in SM exposed individuals. The pathogenesis of abnormal angiogenesis in cherry angioma is not well known but the role of inflammatory mediators and certain hormones, including prolactin, in the regulation of angiogenesis in other diseases has been reported. Read More

Acta Derm Venereol 2013 Jul;93(4):471-2

Eur J Dermatol 2011 Nov-Dec;21(6):864-5

Department of Dermatology and Allergy, Technische Universität München, Munich, Germany.

Cherry angioma is a common, acquired, vascular proliferation, probably of a polygenic mode of inheritance. Segmental manifestation of multiple cherry angiomas associated with the development of non-segmental lesions has not yet been reported. We describe a 62-year-old Caucasian woman with early formation of segmental cherry angiomas after pregnancy, which are superimposed on non-segmental lesions of later onset after menopause. Read More

J Cosmet Laser Ther 2011 Aug 20;13(4):138-41. Epub 2011 Jun 20.

Department of Dermatology, Ondokuz Mayis University School of Medicine, Samsun, Turkey.

Background: Laser therapy is the treatment of choice for cherry angiomas since it is more effective and has better cosmetic results. There is no comparative study about the treatment efficacies with KTP and Nd:YAG lasers for cherry angiomas.

Objective: To compare the efficacy and side effects of 532-nm KTP and 1064-nm Nd:YAG lasers for the treatment of cherry angiomas. Read More

Clin Exp Dermatol 2011 Jul 4;36(5):506-8. Epub 2011 Apr 4.

Royal Free Hospital, London, UK.

Fabry disease (FD) is a lysosomal storage disorder. The prevalence and clinical spectrum is higher than previously thought. The average time between onset of symptoms and diagnosis is 10 years. Read More

PLoS One 2010 Dec 14;5(12):e14334. Epub 2010 Dec 14.

Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

Background: Senile hemangioma, so-called cherry angioma, is known as the most common vascular anomalies specifically seen in the aged skin. The pathogenesis of its abnormal angiogenesis is still unclear.

Methodology/principal Findings: In this study, we found that senile hemangioma consisted of clusters of proliferated small vascular channels in upper dermis, indicating that this tumor is categorized as a vascular tumor. Read More

J Am Acad Dermatol 2010 Dec;63(6):1052-7

Division of Dermatology, Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Quebec, Canada.

Background: Vascular tumors and malformations can be challenging to diagnose. Although they may initially appear very similar, they have distinct clinical courses and management. Wilms tumor 1 (WT1) gene expression has been reported in many different tumors including hematologic malignancies and some solid tumors. Read More

G Ital Dermatol Venereol 2009 Oct;144(5):557-72

Laser Surgery and Cosmetic Dermatology Centers, Bryn Mawr, PA, USA.

The concept of selective photothermolysis simply states that if one heats target tissue with a laser that is selectively absorbed by that tissue, heat should last sufficiently enough to cause damage to the target tissue, but not so long for the heat to spread to the surrounding tissue. The pulsed-dye laser (PDL) was the first laser to utilize the concept of selective photothermolysis to treat dermatologic conditions. The first application of this concept was directed at treating port-wine stain birthmarks (PWSs). Read More

Neurosurgery 2009 May;64(5 Suppl 2):296-9; discussion 299-300

Department of Neurosurgery, Erasmus Medical Center, Rotterdam, The Netherlands.

Objective: Recent advances in microsurgical techniques facilitate surgical resection of brainstem lesions that were previously considered inoperable. In this article we present, for the first time, the tonsillouveal transaqueductal approach to access a progressively symptomatic cavernoma within the depth of the tegmentum of the mesencephalon.

Methods: A 52-year-old woman presented with a history of slowly progressive right-sided hemiparesis and ataxia. Read More

Australas J Dermatol 2009 May;50(2):141-3

Monash University, Alfred Hospital, Melbourne, Victoria, Australia.

A 37 year-old-woman presented for cosmetic removal of a 7-mm (diameter) cherry angioma on her right anterior thigh. Various treatment options were discussed and removal of the lesion using pulsed-dye laser was carried out. The patient returned 5 weeks later complaining of bleeding from the treatment site, which on examination showed a 23 x 23-mm friable nodular lesion with the typical appearance of a pyogenic granuloma. Read More

Int J Dermatol 2008 Dec;47(12):1284-6

Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, China.

Case Rep Dermatol 2009 Nov 11;1(1):82-86. Epub 2009 Nov 11.

Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.

Cherry angiomas are a common cutaneous vascular proliferation which manifests as single or multiple spots and occurs predominantly on the upper trunk and arms. They typically appear as round-to-oval, bright, red, dome-shaped papules and pinpoint macules measuring up to several millimeters in diameter. The histopathologic findings of a cherry angioma are consistent with a true capillary hemangioma, which is formed by numerous, newly developed capillaries with narrow lumens and prominent endothelial cells arranged in a lobular fashion in the papillary dermis. Read More

Ann Acad Med Stetin 2009 ;55(1):15-21

Klinika Chirurgii Dzieciecej i Onkologicznej Pomorskiej Akademii Medycznej w Szczecinie ul. Unii Lubelskiej 1, 71-252 Szczecin.

Introduction: This study was undertaken to evaluate the effectiveness of intralesional corticosteroid therapy in infantile hemangiomas.

Material And Methods: The study was done in 38 patients aged 1 month to 14 years with infants accounting for 84% of all patients. Physical investigation was carried out before and after treatment. Read More

Int J Surg Pathol 2010 Feb 19;18(1):48-54. Epub 2008 Sep 19.

Department of Pathology, University Medical Centre Groningen, University of Groningen, Groningen, Netherlands.

The author reviews and compares the clinicopathological features of papillary hemangiomas and glomeruloid hemangiomas, 2 rare, cutaneous intravascular capillary-type vascular lesions with overlapping morphological details. Immunostaining for collagen IV highlighted discriminating features in these lesions. Thin basement membranes and glomeruloid architecture are typical of glomeruloid hemangiomas, whereas papillae with thick mantles of a basement membrane- like matrix enveloping pericytes are prominent in papillary hemangiomas. Read More

J Dermatol 2006 Dec;33(12):877-9

Department of Dermatology, The Airforce General Hospital of Chinese People's Liberation Army, Beijing, China.

We report a 27-year-old man who had suffered with vitiligo for 7 years and with eruptive cherry angiomas within or around the repigmented vitiliginous skin for 2 years. After continual therapy for vitiligo with topical nitrogen mustard in a concentration of 0.001% for 5 years, multiple cherry angiomas erupted within or around the repigmented vitiliginous plaques. Read More

Australas J Dermatol 2006 Aug;47(3):198-203

Department of Dermatology/Laser,Royal Children's Hospital, Parkville, Victoria, Australia.

A female infant presented at 3 months of age with vascular lesions involving the left lower limb and left side of the vulva. At birth, the left leg was thinner than the right, but equal in length. She had macular, reticulate, bluish discolouration covering most of the skin of the involved leg with superimposed cherry-red papules, most dense over the proximal portion. Read More

Neurol India 2006 Mar;54(1):89-90

Department of Neurosurgery, Graduate School of Medicine, Osaka City University, Osaka, Japan.

A rare case of hemangioblastoma located in the region of hippocampus is reported. A 27-year-old female presented with a single episode of generalized convulsion. The vascular and cherry red color hemangioblastoma was resected by a temporo-zygomatic approach. Read More

Ann Plast Surg 2006 Feb;56(2):164-70

Department of Plastic and Reconstructive Surgery, Rambam Medical Center, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Recently, lasers and light systems are used more for the treatment of vascular lesions due to their noninvasiveness, ease of use, and short recovery time. This side-by-side prospective study compares results, satisfaction, and complications after intense pulsed light (IPL) and Nd:Yag laser treatment of small vascular lesions. Twenty-five patients with telangiectases, leg veins, or cherry angiomas underwent treatment of the same category of lesion in the same area. Read More

Dermatology 2004 ;209(2):132-4

Department of Dermatology, University of Graz Medical School, Graz, Austria.

Intravascular large B-cell lymphoma is a malignant neoplasm characterized by the proliferation of large B cells (rarely of T lymphocytes) confined within the blood vessels. Although the disease can be limited to the skin, involvement of other organs is common. We report a case of intravascular large B-cell lymphoma colonizing the vessels of preexisting cutaneous cherry hemangiomas. Read More

Clin Exp Dermatol 2003 Nov;28(6):581-3

Department of Dermatology, Monklands Hospital, Airdrie, UK.

Patients with vascular spiders and angiomas, especially on exposed sites, demonstrate considerable psychological morbidity and therefore request treatment. Traditionally, electrosurgical modalities have been used to treat such lesions, but more recently lasers have been introduced. This open study assesses the efficacy of these two treatment modalities, scoring patients' preference and psychological morbidity before and after treatment. Read More

J Neurosurg 2002 May;96(5):964

Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA.

Skeletal Radiol 2002 Mar 18;31(3):162-5. Epub 2001 Dec 18.

Center for Vascular and Interventional Radiology, St. Vincent Mercy Medical Center, Department of Radiology, 2213 Cherry Street, Toledo, OH 43608, USA.

Percutaneous vertebroplasty, a minimally invasive interventional radiological procedure, has recently been used effectively for the treatment of symptomatic vertebral body compression fractures. Primary indications for vertebroplasty include osteoporotic compression fracture, osteolytic vertebral metastasis and myeloma, and vertebral hemangioma. We present a case and extend the indication of percutaneous vertebroplasty in a patient with a vertebral body compression fracture secondary to osteogenesis imperfecta. Read More

Dermatology 2001 ;202(1):52-3

Dermatology Institute, Clalit Health Services, Soroka University Medical Center, Ben-Gurion University of the Negev, Faculty for Health Sciences, Beer-Sheva, Israel.

Cherry angiomas are the most common vascular proliferation; however, little is known about the pathogenesis and etiology of these lesions. We present two laboratory technicians who were exposed to brominated compounds for prolonged periods and who developed multiple cherry angiomas on the trunk and extremities. We suggest that the association between exposure to bromides and cherry angiomas should be investigated by a controlled study. Read More

Chir Narzadow Ruchu Ortop Pol 2000 ;65(5):493-7

Katedra i Klinika Ortopedii, Akademia Medyczna w Łodzi.

The paper presents the clinical problems related to soft tissue hemangiomas of the lower limbs basing on our material consisting of 19 patients, their age ranging from 1.5 to 53 years (average 17.4 years). Read More

J Investig Dermatol Symp Proc 2000 Dec;5(1):83-6

Department of Pediatrics, Northwestern University Medical School, Chicago, Illinois, USA.

Vascular tumors occur in approximately 10% of infants, and range from small cherry-red lesions to large, life-threatening tumors. Although the majority of these tumors involute after several years, there are few therapeutic options and their use is limited by the risk of side-effects. The recent increase in understanding of angiogenesis has led to investigations of new antiangiogenic treatment options using models of vascular tumors in mice. Read More

Br J Dermatol 2000 Aug;143(2):356-9

Department of Dermatology, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, U.K.

Background: Vascular lesions, especially on exposed sites, can be unsightly and may cause significant psychological distress. Lasers are effective in treating such lesions, but relatively few studies have been performed looking at psychological scoring before and after laser therapy.

Objectives: To assess the change in psychological distress in patients with vascular lesions following laser treatment. Read More

J Am Acad Dermatol 2000 Jul;43(1 Pt 1):37-41

Wellman Laboratories of Photomedicine, Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114, USA.

Objective: To chronicle the pathophysiologic changes that occur subsequent to laser treatment of vascular lesions, we used a confocal scanning laser microscope that yields high-resolution microscopic images of skin in vivo.

Methods: Cherry angiomas were treated with the 585-nm flashlamp-pumped pulsed-dye laser (PDL) and the 568-nm continuous-wave krypton laser. Repeated confocal reflectance imaging was performed before and immediately after treatment, as well as after several hours, 1 day, 2 days, 1 week, 2 weeks, 3 weeks, and 4 weeks. Read More

J Cutan Pathol 2000 Feb;27(2):87-92

Department of Dermatology, Kyoto Prefectural University of Medicine, Japan.

The case of a Japanese woman with glomeruloid hemangioma, an initial marker for POEMS syndrome, is reported. Her cutaneous lesions were multiple and consisted of glomeruloid hemangiomas, cherry-type capillary hemangiomas, and a mixture of both. The specimens of glomeruloid hemangiomas were studied by paraffin section immunohistochemistry with a large panel of antibodies and electron microscopy, respectively. Read More

J Dermatol 1999 Sep;26(9):577-86

Department of Dermatology, Okinawa-Asia Research Center of Medical Science, Faculty of Medicine, University of the Ryukyus, Japan.

The "densities" of mast cells (MCs) in six kinds of vascular proliferation, pyogenic granuloma, portwine stain, cavernous hemangioma, cherry angioma, Kaposi's sarcoma, and malignant hemangioendothelioma (MHE), measured per mm2 were studied using respective specimens prepared with tryptase stain and a personal computer. The average densities of MCs in pyogenic granuloma and MHE were 103.5 +/- 25. Read More

J Am Acad Dermatol 1999 Apr;40(4):646-7

Med Pregl 1998 Nov-Dec;51(11-12):547-50

Odeljenje za uho, nos i grlo, Opsta bolnica, Zdravstveni centar, Subotica.

Case Description: A patient aged 31 was admitted to the Ward because of hoarseness and difficulties in breathing. Family case history was negative. Personal case history shows pneumonia and jaundice. Read More

J Occup Environ Med 1998 Dec;40(12):1059-64

Department of Family Medicine, School of Medicine, East Carolina University, Greenville, NC, USA.

Seven clerical workers were evaluated in 1993, 8 months after exposure to vaporized 2-butoxyethanol (2-BE; also called butyl cellosolve or ethylene glycol monobutyl ether [EGMBE or EGBE]), which had been applied overnight to strip the floor of their file room. At the time of exposure, they had noted intense eye and respiratory irritation, marked dyspnea, nausea, and faintness, suggesting a concentration of 2-BE in the air of 200-300 parts per million (ppm). All seven workers later experienced recurrent eye and respiratory irritation, dry cough, and headache. Read More

Br J Dermatol 1998 May;138(5):769-73

Division of Dermatology, Nagasaki Ekisaikai Hospital, Japan.

It is known that granuloma pyogenicum (GP) grows rapidly but cherry angioma (CA) does not, although they show the same histological features of hyperplasia of the capillary vessels. Although some cytokines have been thought to be angiogenic factors, a nitric oxide (NO) synthase-dependent effector mechanism is reported to be involved in macrophage-derived angiogenesis in humans. Under the hypothesis that this mechanism is also involved in the more rapid growth of GP, we examined the expression of inducible NO synthase (iNOS) in GP as compared with that in CA. Read More

Int J Dermatol 1997 Nov;36(11):865-9

Department of Dermatology, University of California School of Medicine, San Francisco, USA.

Background: The flashlamp-pumped dye laser, using either a 3 or 5 mm spot size, is an excellent instrument for the treatment of port-wine stains and other superficial cutaneous vascular lesions. Problems exist with patient acceptance due to prominent and prolonged blue-black discoloration and the pain associated with the treatment.

Objective: To assess the effectiveness of a flashlamp-pumped dye laser equipped with a 2 mm spot size lens in the treatment of superficial vascular lesions. Read More

Klin Monbl Augenheilkd 1996 Aug-Sep;209(2-3):176-7

Universitäts-Augenklinik Ulm.

A 72-year-old woman presented with a lesion in her right eye, which had developed over 2 years. The cherry red lesion was located in the bulbar conjunctiva in the area of the plica semilunaris. Ophthalmologic examination was otherwise normal. Read More

Acta Derm Venereol 1994 Jan;74(1):51-3

Anatomisches Institut, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.

A strong correlation has been found between carbonic anhydrase (CA) activity and fenestrations in juxtaepithelial capillaries of several tissues, including psoriatic lesions of human skin. In the present study we demonstrate that the majority of the capillaries in cherry hemangiomas are fenestrated and histochemically react CA positively. Obviously the occurrence of CA in these capillaries corresponds to the fenestrations of venous capillaries, which are numerously revealed by electron microscopy. Read More

Arch Dermatol Res 1992 ;284(5):275-82

Department of Anatomy, Friedrich-Alexander University of Erlangen-Nürnberg, Federal Republic of Germany.

The capillaries in cherry haemangiomas show perivascular hyalinized sheaths. In order to clarify the nature of this sheath material, the extracellular matrix of cherry haemangiomas from 20 normal volunteers (age range 30-64 years) was investigated using immunohistochemical and electronmicroscopical methods. Antibodies against collagen types III, IV and VI and laminin were used. Read More