1,322 results match your criteria Chempluschem[Journal]


Sulphonamidic Groups as Electron-Withdrawing Units in Ureido-Based Anion Receptors: Enhanced Anion Complexation versus Deprotonation.

Chempluschem 2020 Jul;85(7):1401-1411

Department of Analytical Chemistry, Institute of Chemical Process Fundamentals of CAS v.v.i, Rozvojová 135, Prague 6, 16502, Czech Republic.

A sulphonamidic moiety was utilized as an electron-withdrawing group for enhancement of anion complexation features of urea-based receptors. A series of receptors varying in acidity of sulphonamidic and urea NH groups was synthesized and thoroughly tested. The individual complexation properties reflect deprotonation/complexation equilibrium in a given molecule as a function of the substitution. Read More

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http://dx.doi.org/10.1002/cplu.202000326DOI Listing

SQM/COSMO Scoring Function: Reliable Quantum-Mechanical Tool for Sampling and Ranking in Structure-Based Drug Design.

Chempluschem 2020 Jun 2. Epub 2020 Jun 2.

Institute of Organic Chemistry, and Biochemistry of Czech Academy of Sciences, Flemingovo namesti 2, 166 10, Prague, Czech Republic.

Quantum mechanical (QM) methods have been gaining importance in structure-based drug design where a reliable description of protein-ligand interactions is of utmost significance. However, strategies i. e. Read More

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http://dx.doi.org/10.1002/cplu.202000120DOI Listing

Scalable Fabrication of Biophotoelectrodes by Means of Automated Airbrush Spray-Coating.

Chempluschem 2020 Jul;85(7):1396-1400

Analytical Chemistry - Center for Electrochemical Sciences (CES), Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Universitätsstr. 150, 44780, Bochum, Germany.

The fabrication and electrochemical evaluation of transparent photoelectrodes consisting of Photosystem I (PSI) or Photosystem II (PSII) is described, which are embedded and electrically wired by a redox polymer. The fabrication process is performed by an automated airbrush-type spray coating system, which ensures controlled and scalable electrode preparation. As proof of concept, electrodes with a surface area of up to 25 cm were prepared. Read More

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http://dx.doi.org/10.1002/cplu.202000291DOI Listing

Bis-Selenoureas for Anion Binding: A 1H NMR and Theoretical Study.

Chempluschem 2020 Jul;85(7):1389-1395

Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, SS 554 Bivio per Sestu, 09042, Monserrato, CA, IT.

The anion binding ability of a family of bis-selenoureas L1-L3 obtained by the reaction of 1,3-bis(aminomethyl)-benzene and phenylisoselenocyanate, p-methoxyphenylisoselenocyanate and naphtylisoselenocyanate, for L1, L2, and L3, respectively, has been tested and compared to that of previously described bis-urea analogues. Results suggest that the introduction of selenium leads to an increase in the acidity of the urea NH hydrogen atoms, and therefore to a stronger affinity (more than three-fold higher) towards anion species, in particular dihydrogen phosphate, in DMSO-d . Theoretical calculations allowed for the optimization of the adducts receptors corroborating the experimental results. Read More

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http://dx.doi.org/10.1002/cplu.202000260DOI Listing

Development and Biological Applications of Fluorescent Opioid Ligands.

Chempluschem 2020 Jun;85(6):1354-1364

Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy and Food Chemistry, Julius Maximilian University of Würzburg, 97074, Würzburg, Germany.

Opioid receptors (ORs) are classified among the oldest and best investigated drug targets due to their fundamental role in the treatment of pain and related disorders. ORs are divided in three conventional subtypes (μ, κ, δ) and the non-classical nocicepetin receptor. All ORs are family A G protein-coupled receptors (GPCRs), and are located on the cell surface. Read More

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http://dx.doi.org/10.1002/cplu.202000212DOI Listing

Palladium-Catalyzed Insertion of Ethylene and 1,1-Disubstituted Difunctional Olefins: An Experimental and Computational Study.

Chempluschem 2020 Jun;85(6):1200-1209

Polymer Science and Engineering Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Roa, Pune, 411008, India.

Insertion or coordination copolymerization of ethylene with di-substituted olefins is challenging and the choice of di-substituted mono-functional olefin versus di-substituted di-functional olefin (DDO) appears to be decisive. Here we show that DDO-inserted species are amenable to ethylene insertion and polymerization. DDOs such as 2-acetamidoacrylic acid (AAA), methyl 2-acetamidoacrylate (MAAA), and ethyl 2-cyanoacrylate (ECA) were treated with palladium complex [{P∧O}PdMe(L)] (P∧O=κ -P,O-Ar PC H SO O with Ar=2-MeOC H ; L=C H OS) and the existence of respective insertion intermediates in moderate yield (up to 37 %) was established. Read More

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http://dx.doi.org/10.1002/cplu.202000309DOI Listing

Chemical-Fuel-Driven Assembly in Macromolecular Science: Recent Advances and Challenges.

Chempluschem 2020 Jun;85(6):1190-1199

Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing Forestry University, Beijing, 100083, P. R. China.

In the past decade, chemical-fuel-driven processes have been integrated with synthetic self-assembled systems, in which both the formation and properties can be carefully controlled. This strategy can drive systems far away from equilibrium, tailor the lifetime window of transient self-assembled systems, thus holding promise for future smart, adaptive, self-regulated, and life-like systems. By judging whether the building blocks or transient self-assembled systems participate in the fuel-to-waste conversion, the reported systems can be divided into two classes: dissipative self-assembly and self-assembly under dissipative conditions. Read More

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http://dx.doi.org/10.1002/cplu.202000192DOI Listing

Urchin-Like Cobalt-Copper (Hydr)oxides as an Efficient Water Oxidation Electrocatalyst.

Chempluschem 2020 Jun;85(6):1339-1346

State Key Laboratory of Fine Chemicals, DUT-KTH Joint Education and Research Center on MoleCoCular Devices, Dalian University of Technology (DUT), 116024, Dalian, P. R. China.

The development of efficient and low-cost oxygen evolution reaction (OER) catalysts is essential for the generation of clean hydrogen energy from water splitting. Herein, a novel hierarchical urchin-like cobalt-copper (hydr)oxide in situ grown on copper foam (CoCuO H (S)/CF) was synthesized through the electrochemical transformation of cobalt-copper sulfides (Co S -Cu S) via anodization process. This CoCuO H (S)/CF anode exhibited a low overpotential (η) of 274 mV at a current density of 100 mA cm with a robust durability over a period of 40 h when operated at 10 mA cm . Read More

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http://dx.doi.org/10.1002/cplu.202000312DOI Listing

Influence of Protein Modification and Glycosylation in the Catalytic Hydrogen Evolution Reaction of Avidin and Neutravidin: An Electrochemical Analysis.

Chempluschem 2020 Jun;85(6):1347-1353

Institute of Biophysics, The Czech Academy of Sciences, Královopolská 135, 61265, Brno, Czech Republic.

To investigate glycans' influence on the behavior of glycoproteins on charged surfaces, avidin and its nonglycosylated and neutralized version neutravidin were studied by label-free chronopotentiometric stripping (CPS) analysis and alternating current voltammetry combined with a mercury electrode. Despite neutravidin's and avidin's similar size and structure, their CPS responses differed due to the different amounts of catalytically active free amino groups of lysine and arginine residues. Acetylation of the proteins resulted in the suppression of their CPS responses by almost four times for avidin and by about 50 % for neutravidin, respectively. Read More

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http://dx.doi.org/10.1002/cplu.202000298DOI Listing

Synthesis and Structural Characterisation of an N-Phosphanyl Ferrocene Carboxamide and its Ruthenium, Rhodium and Palladium Complexes.

Chempluschem 2020 Jun;85(6):1325-1338

Department of Inorganic Chemistry, Faculty of Science, Charles University, Hlavova 2030, 128 40, Prague, Czech Republic.

[((Diphenylphosphanyl)amino)carbonyl]ferrocene (1) has been synthesized and coordinated to light platinum metals, ruthenium, rhodium and palladium, in diverse coordination modes. Specifically, compound 1 was used to prepare the following phosphane complexes, [(η -mes)RuCl (1-κP)], [(η -C Me )RhCl (1-κP)], trans-[PdCl (1-κP) ], and [(L )PdCl(1-κP)] (mes=mesitylene, L =[2-(dimethylamino-κN)methyl]phenyl-κC ). They were subsequently converted into cationic O,P-chelate complexes by halide abstraction with AgClO and into neutral O,P-chelate complexes by deprotonation with potassium tert-butoxide. Read More

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http://dx.doi.org/10.1002/cplu.202000303DOI Listing

Supported Cobalt Catalysts for Acceptorless Alcohol Dehydrogenation.

Chempluschem 2020 Jun;85(6):1315-1324

IRCELYON, Univ Lyon, Université Claude Bernard Lyon 1, CNRS, 69626, Villeurbanne, France.

The acceptor-less dehydrogenation of 2-octanol was tested over cobalt supported on Al O , C, ZnO, ZrO and various TiO substrates. The catalysts were characterized by ICP, XRD and TGA-H . For Co/TiO P25, the effects of passivation, aging (storage at room temperature), and in situ activation under H were investigated. Read More

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http://dx.doi.org/10.1002/cplu.202000359DOI Listing

Solvent-Dependent Bending Ability of Salen-Derived Organic Crystals.

Chempluschem 2020 May 22. Epub 2020 May 22.

Department of Chemistry, Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto, 860-8555, Japan.

The formation of plastic or brittle organic crystals of salen derivatives that depend on the solvents employed for crystallization is demonstrated. Large yellow crystals (ranging from mm to cm size) of ten different salen derivatives were obtained and investigated. Among them, (bis(2-hydroxyacetophenone)ethylenediimine) 2, which was recrystallized from dichloromethane, tetrahydrofuran or chloroform, exhibited plastic deformation behaviour when mechanical force was applied to the (001) face. Read More

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http://dx.doi.org/10.1002/cplu.202000362DOI Listing

Functionalized Chiral Bambusurils: Synthesis and Host-Guest Interactions with Chiral Carboxylates.

Chempluschem 2020 Jun;85(6):1307-1314

Department of Chemistry and RECETOX Faculty of Science, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.

Bambusurils are a class of macrocyclic anion receptors that exhibit notable anion recognition properties, able to bind various inorganic anions as well the carboxylates or sulfonates. Recently, we reported enantioselective recognition of chiral carboxylates using non-functionalized chiral bambusuril derivatives. Herein, we report the synthesis and host-guest properties of two new representatives of chiral bambusuril macrocycles bearing ester functional groups, differing by the substituents attached to their portals. Read More

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http://dx.doi.org/10.1002/cplu.202000261DOI Listing

Acid-Stable Ester Linkers for the Solid-Phase Synthesis of Immobilized Peptides.

Chempluschem 2020 Jun;85(6):1297-1306

Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, 166 10, Prague 6, Czech Republic.

A series of N-terminally Fmoc-protected linkers of the general formula Fmoc-X-CO-O-Y-COOH have been prepared, where X is -NH-CH -CH - or -p-(aminomethyl)phenyl- and Y is -(CH ) - (n is 1 or 4) or -p-(methyl)phenyl-. These linkers can easily be covalently attached via their C-terminal carboxyl group to a resin bearing a free amino group. After cleavage of the N-terminal Fmoc group, the linkers can be extended by standard solid-phase peptide synthesis techniques. Read More

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http://dx.doi.org/10.1002/cplu.202000246DOI Listing

Pyrolysis of Iron-Containing Polyanilines under Micropore Generation Control: Electrocatalytic Performance in the Oxygen Reduction Reaction.

Chempluschem 2020 Jun 18. Epub 2020 Jun 18.

The Institute of Scientific and Industrial Research, Osaka University, Mihoga-oka, Ibaraki, Osaka, 567-0047, Japan.

Pyrolyzed iron-containing polyaniline (C-Fe-PANI) is one of the most promising candidates as a non-precious metal based electrocatalyst for oxygen reduction reaction (ORR). Although the ORR activity depends on the surface area arisen from pyrolysis-generated micropores on C-Fe-PANI particles, the micropore generation is hindered by pyrolysis-formed iron nanoparticles (Fe NPs) embedded inside C-Fe-PANI particles. Here, we demonstrate the pyrolysis of iron-containing PANIs under suppression of micropore-generation hindrance by blocking the Fe NPs formation. Read More

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http://dx.doi.org/10.1002/cplu.202000363DOI Listing

High-Pressure-Mediated Thiourea-Organocatalyzed Asymmetric Michael Addition to (Hetero)aromatic Nitroolefins: Prediction of Reaction Parameters by PCP-SAFT Modelling.

Chempluschem 2020 Jun;85(6):1292-1296

Institute of Organic Chemistry, University of Regensburg, Universitätsstr. 31, 93053, Regensburg, Germany.

Thiourea-organocatalyzed Michael additions of diethyl malonate to various heteroaromatic nitroolefins (13 examples) have been studied under high-pressure (up to 800 MPa) and ambient pressure conditions. High pressure was conducive to enhanced product yields by a factor of 2-12 at a given reaction time, high reaction rates (reaction times were decreased from 72-24 h down to 4-24 h) and high enantioselectivity. Elucidating the effects of solvents for maximizing reaction rates and yields has been carried out using the Perturbed-Chain Polar Statistical Associating Fluid Theory (PCP-SAFT), allowing for the first time a prediction of the kinetic profiles under high-hydrostatic-pressure conditions. Read More

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http://dx.doi.org/10.1002/cplu.202000364DOI Listing

Biomimetic Gemcitabine-Lipid Prodrug Nanoparticles for Pancreatic Cancer.

Chempluschem 2020 Jun;85(6):1283-1291

CSIRO Manufacturing, P.O. BOX 52, North Ryde, NSW, 1670, Australia.

Gemcitabine (Gem) is a key drug for pancreatic cancer, yet limited by high systemic toxicity, low bioavailability and poor pharmacokinetic profiles. To overcome these limitations, Gem prodrug amphiphiles were synthesised with oleyl, linoleyl and phytanyl chains. Self-assembly and lyotropic mesophase behaviour of these amphiphiles were examined using polarised optical microscopy and Synchrotron SAXS (SSAXS). Read More

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http://dx.doi.org/10.1002/cplu.202000253DOI Listing

Covalent Post-Assembly Modification: A Synthetic Multipurpose Tool in Supramolecular Chemistry.

Chempluschem 2020 Jun;85(6):1249-1269

School of Chemistry and Key Center for Polymers and Colloids, The University of Sydney, Sydney, NSW 2006, Australia.

The use of covalent post-assembly modification (PAM) in supramolecular chemistry has grown significantly in recent years, to the point where PAM is now a versatile synthesis tool for tuning, modulating, and expanding the functionality of self-assembled complexes and materials. PAM underpins supramolecular template-synthesis strategies, enables modular derivatization of supramolecular assemblies, permits the covalent 'locking' of unstable structures, and can trigger controlled structural transformations between different assembled morphologies. This Review discusses key examples of PAM spanning a range of material classes, including discrete supramolecular complexes, self-assembled soft nanostructures and hierarchically ordered polymeric and framework materials. Read More

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http://dx.doi.org/10.1002/cplu.202000279DOI Listing

Dynamic Covalent Chemistry as a Facile Route to Unusual Main-Group Thiolate Assemblies and Disulfide Hoops and Cages.

Chempluschem 2020 Jun;85(6):1270-1282

Department of Chemistry, Biochemistry and Materials Science Institute, University of Oregon, Eugene, OR 97403-1253, USA.

Dynamic Covalent Chemistry (DCC) - combining the robustness of covalent bonds with the self-correcting nature of supramolecular chemistry - facilitates the modular synthesis of complex molecular assemblies in high yields. Although numerous reactions form covalent bonds, only a small set of chemical transformations affect covalent bond formation reversibly under suitable conditions for DCC. Further progress in this area still requires the identification of dynamic motifs and greater insights into their reversibility. Read More

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http://dx.doi.org/10.1002/cplu.202000257DOI Listing

Separation and Detection of meta- and ortho-Substituted Benzene Isomers by Using a Water-Soluble Pillar[5]arene.

Chempluschem 2020 Jun;85(6):1244-1248

Smart Hybrid Materials Laboratory (SHMs) Advanced Membranes and Porous Materials Center (AMPMC), King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.

Efficient and energy-saving separation of benzene isomers bearing a diverse range of functional groups is a great challenge due to their overlapping physicochemical properties. Here, we report the successfully use of a water-soluble pillar[5]arene (WP5) as a multifunctional material for the separation and detection of meta/ortho-substituted benzene isomers in water. A liquid-liquid extraction strategy was used for the separation of these benzene isomers based on their different affinity for WP5 in water. Read More

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http://dx.doi.org/10.1002/cplu.202000275DOI Listing

Genetic Code Expansion Facilitates Position-Selective Modification of Nucleic Acids and Proteins.

Chempluschem 2020 Jun;85(6):1233-1243

Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Goethe University Frankfurt, Max-von-Laue-Strasse 7, 60438, Frankfurt am Main, Germany.

Transcription and translation obey to the genetic code of four nucleobases and 21 amino acids evolved over billions of years. Both these processes have been engineered to facilitate the use of non-natural building blocks in both nucleic acids and proteins, enabling researchers with a decent toolbox for structural and functional analyses. Here, we review the most common approaches for how labeling of both nucleic acids as well as proteins in a site-selective fashion with either modifiable building blocks or spectroscopic probes can be facilitated by genetic code expansion. Read More

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http://dx.doi.org/10.1002/cplu.202000150DOI Listing

Self-Assembly and Biorecognition of a Spirohydantoin Derived from α-Tetralone: Interplay between Chirality and Intermolecular Interactions.

Chempluschem 2020 Jun;85(6):1220-1232

Department of General and Inorganic Chemistry, Department of Organic Chemistry, Faculty of Technology and Metallurgy, University of Belgrade Karnegijeva 4, 11120 Belgrade (Serbia).

A racemic spirohydantoin derivative with two aromatic substituents, a tetralin and a 4-methoxybenzyl unit, was synthesized and its crystal structure was determined. To define the relationship between molecular stereochemistry and spatial association modes, development of the crystal packing was analyzed through cooperativity of intermolecular interactions. Homo and heterochiral dimeric motifs were stabilized by intermolecular N-H⋅⋅⋅O, C-H⋅⋅⋅O, C-H⋅⋅⋅π interactions and parallel interactions at large offsets (PILO), thus forming alternating double layers. Read More

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http://dx.doi.org/10.1002/cplu.202000273DOI Listing

A Series of Manganese(III) Salen Complexes as a Result of Team-Based Inquiry in a Transnational Education Programme.

Chempluschem 2020 Jun;85(6):1210-1219

The Lennard Jones Laboratories, School of Chemical and Physical Sciences, Keele University, Keele, ST5 5BG, United Kingdom.

The development of a team-based approach to research-led transnational practical chemistry teaching is described in which a team of five Chinese students on an articulated transnational degree programme, supported by a team of academic and technical staff, carried out a study examining the structural chemistry of a series of manganese(III) salen complexes. A series of four crystallographically characterized manganese(III) salen complexes with ancillary carboxylate ligands are reported here. The carboxylate coordination modes range from the bridging syn-anti μ -κO : κO' mode observed in the predominant cyclohexanoate and isobutyrate species, to a capping terminal monodentate mode for the adamantanoate species, and an unusual mixture of bridging and terminal coordination modes observed in a second minor phase of the cyclohexanoate species. Read More

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http://dx.doi.org/10.1002/cplu.202000337DOI Listing

Controlled Release of Reactive Gases: A Tale of Taming Carbon Monoxide.

Chempluschem 2020 May 22. Epub 2020 May 22.

Carbon Dioxide Activation Center (CADIAC), Department of Chemistry and the, Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wieds Vej 14, 8000, Aarhus C, Denmark.

This Personal Account describes the development of air-stable and solid precursors for on-demand release of carbon monoxide. In combination with the development of a two-chamber reactor, COware®, CO liberation can be achieved under safe working conditions, as well as allowing transition metal-mediated carbonylations with stoichiometric carbon monoxide. Particularly appealing is the adaptability of this chemical technology for the preparation of carbon isotope labeled bioactive compounds. Read More

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http://dx.doi.org/10.1002/cplu.202000319DOI Listing

Hetero-Tetranuclear Cu /Ca /Ca /Cu Architectures Based On Malten Ligand: Scaffold for Anion Binding.

Chempluschem 2020 Jun;85(6):1179-1189

Department of Pure and Applied Sciences, University of Urbino "Carlo Bo", Via della Stazione 4, 61029, Urbino, Italy.

The hetero-tetranuclear Cu /Ca /Ca /Cu complex obtained with the N,N'-bis((3-hydroxy-4-pyron-2-yl)methyl)-N,N'-dimethylethylendiamine (Malten) ligand has been studied in solid and solution states as scaffold to bind anions. Three crystal structures showing the same metal ions sequence have been examined; they display a tetracharged complex cation neutralized by four monocharged anions. The anions play two different roles: as coordinated (two ClO , Cl or NO ) or ancillary (two ClO ) guests. Read More

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http://dx.doi.org/10.1002/cplu.202000307DOI Listing

Doxorubicin-Conjugated Iron Oxide Nanoparticles: Surface Engineering and Biomedical Investigation.

Chempluschem 2020 Jun;85(6):1156-1163

Department of Polymer Particles, Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského nám. 2, 162 06, Prague 6, Czech Republic.

Development of therapeutic systems to treat glioblastoma, the most common and aggressive brain tumor, belongs to priority tasks in cancer research. We have synthesized colloidally stable magnetic nanoparticles (D =336 nm) coated with doxorubicin (Dox) conjugated copolymers of N,N-dimethylacrylamide and either N-acryloylglycine methyl ester or N-acryloylmethyl 6-aminohexanoate. The terminal carboxyl groups of the copolymers were reacted with alendronate by carbodiimide formation. Read More

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http://dx.doi.org/10.1002/cplu.202000360DOI Listing

Cyclodextrin-Based Organic Radical Contrast Agents for in vivo Imaging of Gliomas.

Chempluschem 2020 Jun;85(6):1171-1178

Kuopio Biomedical Imaging Unit A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Neulaniementie 2, 70211, Kuopio, Finland.

Cyclodextrins (CDs), a class of cyclic oligosaccharides formed by α-(1,4) linked glucopyranose units, were functionalized with (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) radicals to prepare water soluble supramolecular organic radical contrast agents (ORCAs) for the in vivo detection of glioma tumor in animal models. A first set of molecules (CDn1, n=6,7,8 is the number of both TEMPO and glucopyranose units) was studied by superconducting quantum interference devices (SQUID) magnetometry in order to define the role of the CD macrocycle on the effective magnetic moment (μ ). The μ value increased from 3. Read More

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http://dx.doi.org/10.1002/cplu.202000190DOI Listing
June 2020
3.242 Impact Factor

2-Formyl-dATP as Substrate for Polymerase Synthesis of Reactive DNA Bearing an Aldehyde Group in the Minor Groove.

Chempluschem 2020 Jun;85(6):1164-1170

Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo namesti 2, 16610, Prague 6, Czech Republic.

2-Formyl-2'-deoxyadenosine triphosphate (d ATP) was synthesized and tested as a substrate in enzymatic synthesis of DNA modified in the minor groove with a reactive aldehyde group. The multistep synthesis of d ATP was based on the preparation of protected 2-dihydroxyethyl-2'-deoxyadenosine intemediate, which was triphosphorylated and converted to aldehyde through oxidative cleavage. The d ATP triphosphate was a moderate substrate for KOD XL DNA polymerase, and was used for enzymatic synthesis of some sequences using primer extension (PEX). Read More

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http://dx.doi.org/10.1002/cplu.202000287DOI Listing
June 2020
3.242 Impact Factor

Bioorthogonal Phosphorogenic Rhenium(I) Polypyridine Sydnone Complexes for Specific Lysosome Labeling.

Chempluschem 2020 Jul 3;85(7):1368. Epub 2020 Jun 3.

Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P. R. China.

Invited for this month's cover is the group of Prof. Kenneth Kam-Wing Lo at City University of Hong Kong, Hong Kong, P. R. Read More

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http://dx.doi.org/10.1002/cplu.202000346DOI Listing

Lithium-Ion-Based Electrochemical Energy Storage in a Layered Vanadium Formate Coordination Polymer.

Chempluschem 2020 Jun;85(6):1137-1144

School of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram (IISER TVM), Maruthamala PO, Vithura, Thiruvananthapuram, 695551, Kerala, India.

A vanadium formate (VF) coordination polymer and its composite with partially reduced graphene oxide (prGO), namely VF-prGO, can be applied as anode materials for Li-ion based electrochemical energy storage (EcES) systems in the potential range of 0-3 V (vs Li /Li). This study shows that a reversible capacity of 329 mAh g at a current density of 50 mA g after 50 cycles can be realized for VF along with a high rate capability. The composite exhibits even a higher capacity of 504 mAh g at 50 mA g . Read More

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http://dx.doi.org/10.1002/cplu.202000283DOI Listing

Organic Cages as Building Blocks for Mechanically Interlocked Molecules: Towards Molecular Machines.

Chempluschem 2020 Jun;85(6):1145-1155

Department of Chemistry, University of Pavia, V. le Taramelli 12, 27100, Pavia, Italy.

The research on systems able to perform controllable motions under external stimuli arises great interest in the scientific community. Over the years, a library of innovative devices has been produced, classified in different categories according to the molecular or supramolecular level of motion. This minireview aims to highlight some representative studies, in which organic cages are used as building blocks for mechanically interlocked molecules, and in which intramolecular motions are triggered by external input. Read More

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http://dx.doi.org/10.1002/cplu.202000274DOI Listing

Fabrication of Template-Less Self-Propelled Micromotors Based on A Metal-Sandwiched Polytryptophan Body: An Experimental and DFT Study.

Chempluschem 2020 Jun;85(6):1129-1136

Department of Chemistry, Razi University Tagh-e-Bostan, University St., Kermanshah, Iran, 6714414971, Iran.

The diverse capabilities of self-propelled micro/nanomotors open up significant opportunities for various environmental and biomedical applications. Here, a synchronized two-lobed bubble exhaust drives micromotor comprising a metal (cobalt and gold) sandwiched polytryptophan body (Au/poly-Trp/Co) in a non-curved direction. The autonomous motion is achieved through the decomposition of chemical fuel to result in a kayak-like system. Read More

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http://dx.doi.org/10.1002/cplu.202000242DOI Listing
June 2020
3.242 Impact Factor

Stable Trimetallic NiFeCu Catalysts with High Carbon Resistance for Dry Reforming of Methane.

Chempluschem 2020 Jun;85(6):1120-1128

CAS Key Lab of Low-Carbon Conversion Science and Engineering Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, 201210, P. R. China.

Copper has been incorporated into Ni-Fe alloys to form a series of ternary NiFeCu alloy catalysts with molar ratio of Cu/Fe varying from 0 to 1.5, which were tested in dry reforming of methane (DRM) at 923 K and atmospheric pressure with a CH /CO ratio of 1. XRD, TPR-H and FE-TEM measurements confirm the formation of Ni-Fe-Cu alloys with particle size of 5. Read More

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http://dx.doi.org/10.1002/cplu.202000217DOI Listing

Infrared Thermography as a Powerful, Versatile, and Elegant Research Tool in Chemistry: Principles and Application to Catalysis and Adsorption.

Authors:
Boris G Vainer

Chempluschem 2020 Apr 29. Epub 2020 Apr 29.

Novosibirsk State University, Physical Department, 2 Pirogova str., Novosibirsk, 630090, Russia.

In this Review, diverse chemical problems that have been approached by means of infrared thermography (IRT) are covered in depth. Moreover, some novel steps forward in this field are made, described and discussed. Namely, the latest-generation IRT performance capabilities are harnessed in full; the initial phase of catalytic CO oxidation (called "fast ignition") is presented at the 0. Read More

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http://dx.doi.org/10.1002/cplu.202000202DOI Listing

Selective Isolation Methods for Cellulose and Chitin Nanocrystals.

Chempluschem 2020 May;85(5):1081-1088

Dept. Wood Technology and Wood-based Composites, Georg-August-University of Goettingen, Büsgenweg 4, 37077, Göttingen, Germany.

This Minireview focuses on the selective isolation methods for the preparation of cellulose nanocrystals (CNCs) and chitin nanocrystals (ChNCs). Various selective preparation strategies with specific preparation conditions and reaction mechanisms are summarized. In particular, these selective reaction routes include controlled acid hydrolysis and selective oxidations at specific positions of cellulose or chitin fibers as well as particular reaction sites of the repeating monosaccharide building blocks of their main chains. Read More

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http://dx.doi.org/10.1002/cplu.202000250DOI Listing

Intrinsic Luminescence from Nonaromatic Biomolecules.

Chempluschem 2020 May;85(5):1065-1080

School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Lab of Electrical Insulation and Thermal Aging, Shanghai Electrochemical Energy Devices Research Center, Shanghai Jiao Tong University, No. 800 Dongchuan Rd., Minhang District, Shanghai, 200240, P. R. China.

Novel emitters that do not contain traditional chromophores but only electron-rich moieties (e. g. amine, C=O, -OH, ether, and imide), which are classified as nonconventional luminophores, have been more frequently reported. Read More

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http://dx.doi.org/10.1002/cplu.202000021DOI Listing

Robust Guanidine Metal Catalysts for the Ring-Opening Polymerization of Lactide under Industrially Relevant Conditions.

Chempluschem 2020 May;85(5):1044-1052

Institute of Inorganic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.

The increasing awareness of sustainability has led to enormous growth of the demand for bio-based and biodegradable polymers such as poly(lactide) (PLA). In industry, polymerization of lactide is currently carried out using tin catalysts (e. g. Read More

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http://dx.doi.org/10.1002/cplu.202000252DOI Listing

Synthesis of Phospho-Polypeptides via Phosphate-Containing N-Carboxyanhydride: Application in Enzyme-Induced Self-Assembly, and Calcium Carbonate Mineralization.

Chempluschem 2020 May;85(5):1053-1064

Department of Chemical Sciences, Indian Institute of Science Education and Research, Kolkata, Mohanpur Campus, Nadia, West Bengal, 741246, India.

An easy synthetic strategy was developed to synthesize the phosphate-functionalized amino acid N-carboxyanhydride (NCA), using simple primary amine initiators to obtain homo and block phospho-polypeptides with controlled molecular weight and molecular weight distribution. The methodology was extended to the synthesis of the end-functionalized homo polypeptides (15 to 50 repeat unit) and block co-polypeptides with PEG (0.7 K, 2 K, and 5 K) and glycopolypeptide (15-unit mannose glycopolypeptide) as one of the blocks. Read More

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http://dx.doi.org/10.1002/cplu.202000322DOI Listing

Theoretical and Experimental Studies on the Near-Infrared Photoreaction Mechanism of a Silicon Phthalocyanine Photoimmunotherapy Dye: Photoinduced Hydrolysis by Radical Anion Generation.

Chempluschem 2020 May 25. Epub 2020 May 25.

Faculty of Science, Hokkaido University, Sapporo, 060-0810, Japan.

Ligand release from IR700, a silicon phthalocyanine dye used in near-infrared (NIR) photoimmunotherapy, initiates cancer cell death after NIR absorption, although its photochemical mechanism has remained unclear. This theoretical study reveals that the direct Si-ligand dissociation by NIR light is difficult to activate because of the high dissociation energy even in excited states, i. e. Read More

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http://dx.doi.org/10.1002/cplu.202000338DOI Listing

Mesostructured Electroactive Thin Films Through Layer-by-Layer Assembly of Redox Surfactants and Polyelectrolytes.

Chempluschem 2020 May 16. Epub 2020 May 16.

Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP), CONICET, Diagonal 113 y 64, 1900, La Plata, Argentina.

Electroactive thin films are an important element in the devices devoted to energy conversion, actuators, and molecular electronics, among others. Their build-up by the layer-by-layer technique is an attractive choice since a fine control over the thickness and composition can be achieved. However, most of the assemblies described in the literature show a lack of internal order, and their thicknesses change upon oxidation-state alterations. Read More

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http://dx.doi.org/10.1002/cplu.202000358DOI Listing

Correlation of Physicochemical and Antimicrobial Properties of Liposomes Loaded with (+)-Usnic Acid.

Chempluschem 2020 May;85(5):1014-1021

Dipartimento di Scienze Fisiche e Chimiche, Università degli Studi dell'Aquila, Via Vetoio 10, 67010, Coppito (AQ), Italy.

(+)-Usnic acid (UA) is a natural substance that displays pharmacological activity, but it is barely soluble in water, so it was included in liposomes in order to study its properties. First, the effects of phospholipid structure and loading methodology on UA entrapment efficacy were evaluated. Then, the physicochemical and biological properties (UA delivery efficacy to Staphylococcus aureus bacterial cells) of different liposome formulations containing structurally related amphiphiles derived from L-prolinol were fully investigated. Read More

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http://dx.doi.org/10.1002/cplu.202000125DOI Listing

Controlled Supramolecular Polymerization of d Metal Complexes through Pathway Complexity and Seeded Growth.

Chempluschem 2020 May;85(5):1022-1033

Organisch-Chemisches Institut, Westfälische Wilhelms-Universität, Münster, Correnstraße, 40, 48149, Münster, Germany.

In recent years, pathway complexity has been studied in detail for a large variety of organic and π-conjugated molecules. However, such investigations on their metal-containing analogues have received only little attention to date, despite the well-known potential of metal complexes in various fields. In this Minireview, we have collected recent examples of d metal complexes (Pt(II), Pd(II) and Au(III) complexes) exhibiting controlled supramolecular polymerization through pathway complexity and seeded-growth approaches. Read More

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http://dx.doi.org/10.1002/cplu.202000210DOI Listing

Bis(α-hydroxycycloalkyl)phosphine Oxides Obtained from White Phosphorus via Phosphine Oxide H PO: Synthesis, Molecular Structure, Coordination Properties and Biological Activity.

Chempluschem 2020 May;85(5):958-962

A.E. Arbuzov Institute Of Organic And Physical Chemistry, Subdivision of the Federal State Budgetary, Institution of Science "Kazan Scientific Center of Russian Academy of Sciences", Arbuzov str., 8, 420088, Kazan, Russian Federation.

Reaction of the electrochemically in situ from elemental white phosphorus generated phosphine oxide H PO in a single electrochemical cell, supplied with lead cathode and aluminium anode, with cyclic ketones (cyclopentanone and cyclohexanone) results in formation of secondary phosphine oxides (bis(α-hydroxycyclopentyl)phosphine oxide 2 a, isolated yield 15 %, and bis(α-hydroxycyclohexyl)phosphine oxide 2 b, isolated yield 12 %) with two α-hydroxycycloalkyl substituents at the phosphorus atom. Bis(α-hydroxycyclopentyl)phosphine oxide reacts with [PdCl (COD)] (COD=1,5-cyclooctadiene) to give a new palladium complex trans-[PdCl {P(OH)(cyclo-C H -1-OH) } ] (3 a, isolated yield 11 %) bearing phosphinous acid as a ligand formed via tautomerization of the phosphine oxide. Finally, the cytotoxicity of the synthesized secondary phosphine oxides on tumor and healthy human cell lines was studied. Read More

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http://dx.doi.org/10.1002/cplu.202000220DOI Listing

Guanidiniocarbonyl-Pyrroles (GCP) - 20 Years of the Schmuck Binding Motif.

Chempluschem 2020 May;85(5):985-997

Faculty of Chemistry, Organic Chemistry, University of Duisburg-Essen, Universitätsstrasse 7, 45117, Essen, Germany.

In this Minireview, an overview about the past 20 years of the guanidiniocarbonyl-pyrrole (GCP) binding motif, which was designed, investigated and applied by Prof. Dr. Carsten Schmuck, is presented. Read More

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http://dx.doi.org/10.1002/cplu.202000142DOI Listing

An Electrochemical Non-Enzymatic Glucose Sensor Based on Ultrathin PdAg Single-Crystalline Nanowires.

Chempluschem 2020 May;85(5):970-976

Department of Otorhinolaryngology-Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, P. R. China.

Electrochemical non-enzymatic sensors have great potential for prompt and efficient detection of glucose. Herein, a novel, highly efficient electrochemical non-enzymatic glucose sensor is reported that is based on ultrathin PdAg single-crystalline nanowires (NWs). Ultrathin PdAg NWs are fabricated by a facile one-pot aqueous synthesis through an in situ growth strategy with an amphiphilic surfactant as the template. Read More

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http://dx.doi.org/10.1002/cplu.202000141DOI Listing

Encapsulation of Azaphosphatranes and Proazaphosphatranes in Confined Spaces.

Chempluschem 2020 May;85(5):977-984

Aix Marseille Univ, CNRS, Centrale Marseille, iSm2, Marseille, France.

Proazaphosphatranes (also named Verkade's superbases) and their azaphosphatrane conjugated acids have been recently been shown to be confined in either covalent or self-assembled molecular cages, or immobilized in nanopores of hybrid materials. The encapsulation of these phosphorus moieties turns out to strongly affect both their acid-base, catalytic, and recognition properties. The thermodynamics and kinetics of the proton transfer as well as the selectivity and catalytic activities of Verkade's superbases were strongly changed upon their confinement in a hemicryptophane cavity. Read More

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http://dx.doi.org/10.1002/cplu.202000204DOI Listing

Anion Binding of a Cyclopeptide-Derived Molecular Cage in Aqueous Solvent Mixtures.

Chempluschem 2020 May;85(5):963-969

Fachbereich Chemie - Organische Chemie, Technische Universität Kaiserslautern, Erwin-Schrödinger-Straße, 67663, Kaiserslautern, Germany.

A molecular cage consisting of two cyclic hexapeptides with an alternating sequence of (2S,4S)-4-aminoproline and 6-aminopicolinic acid subunits, covalently linked via three diglycolic acid subunits, interacts with a variety of inorganic anions in acetonitrile/water. In the respective complexes, the anion resides in a cavity between the two cyclopeptide rings where it interacts with six converging NH groups. The cage binds sulfate anions in acetonitrile/water, 2 : 1 (v/v) with a log K of 6. Read More

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http://dx.doi.org/10.1002/cplu.202000255DOI Listing

[1]Benzothieno[3,2-b][1]benzothiophene-Phthalocyanine Derivatives: A Subclass of Solution-Processable Electron-Rich Hole Transport Materials.

Chempluschem 2020 May 5. Epub 2020 May 5.

CHOSE- Center for Hybrid and Organic Solar Energy, Electronic Engineering Department, University of Rome Tor Vergata, Via Del Politecnico 1, 00133, Rome, Italy.

The [1]benzothieno[3,2-b][1]benzothiophene (BTBT) planar system was used to functionalize the phthalocyanine ring aiming at synthesizing novel electron-rich π-conjugated macrocycles. The resulting ZnPc-BTBT and ZnPc-(BTBT) derivatives are the first two examples of a phthalocyanine subclass having potential use as solution-processable p-type organic semiconductors. In particular, the combination of experimental characterizations and theoretical calculations suggests compatible energy level alignments with mixed halide hybrid perovskite-based devices. Read More

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http://dx.doi.org/10.1002/cplu.202000281DOI Listing

Additive-Free Conversion of Internal Alkynes by Phosphanylalumanes: Production of Phosphorus/Aluminum Frustrated Lewis Pairs.

Chempluschem 2020 May;85(5):933-942

Institute for Chemical Research, Kyoto University Gokasho, Uji, Kyoto, 611-0011, Japan.

Internal and terminal alkynes react with phosphanylalumanes, i. e., P-Al single-bond species, through heating but without any additional additives. Read More

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http://dx.doi.org/10.1002/cplu.202000239DOI Listing

Anthracene-Pentacene Dyads: Synthesis and OFET Characterization.

Chempluschem 2020 May;85(5):921-926

Department of Chemistry, University of Alberta, Edmonton, Alberta, T6G 2G2, Canada.

The synthesis of a series of unsymmetrical derivatives of pentacene appended with functionalized anthracene moieties is reported. These anthracene-pentacene dyads have been characterized by UV-vis spectroscopy and cyclic voltammetry to examine their electronic properties. X-ray crystallographic analysis was used to examine the solid-state features of anthracene-pentacene dyads 1 a-d with H-, F-, Cl-, and Br- substituents on the 9-position of anthracene, and shows that the packing arrangement of anthracene-pentacene derivatives 1 b,d,e are remarkably similar irrespective of the presence of fluoride, bromide or methyl substituents. Read More

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http://dx.doi.org/10.1002/cplu.202000233DOI Listing