9,897 results match your criteria Chemotherapy-Induced Oral Mucositis
J Pharm Health Care Sci 2018 29;4:29. Epub 2018 Nov 29.
1Department of Pharmacy, Nagoya City University Hospital, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8602 Japan.
Background: To our knowledge, no studies have evaluated the safety of carboplatin (CBDCA)-based chemotherapy in hemodialysis patients > 80 years-old. In addition, the impact of CBDCA-based chemotherapy on such elderly patients' quality of life (QOL) is unknown. We report a case of gemcitabine plus CBDCA chemotherapy treatment in an 81-year-old man with metastatic urothelial carcinoma undergoing hemodialysis. Read More
Med Princ Pract 2018 Dec 3. Epub 2018 Dec 3.
Objective: To report a rare case of maculopapular rash on the scalp in a patient with Mediterranean spotted fever (MSF).
Clinical Presentation And Intervention: A 58-year-old woman with breast cancer and chemotherapy-induced alopecia contracted MSF. Her clinical features were typical, except for a maculopapular rash covering the scalp. Read More
Bioorg Med Chem Lett 2018 Nov 24. Epub 2018 Nov 24.
Drug Discovery Facility - Pune, Advinus Therapeutics Limited, Head Office: Block No. 21 & 22, Phase II, Peenya Industrial Area, Bangalore 560058, India.
Conceptual design and modification of urea moiety in chemotype PF-3845/04457845, the bench marking irreversible inhibitor of fatty acid amide hydrolase (FAAH), led to discovery of a novel nicotinamide-based lead 12a having reversible mechanism of action. Focused SAR around the pyridine heterocycle (Ar) in 12a (Tables 1 and 2) resulted into four shortlisted compounds, (-)-12a, (-)-12i, (-)-12l-m. The required (-)-enantiomers were obtained via diastereomeric resolution of a novel chiral dissymmetric intermediate 15. Read More
Cancer Commun (Lond) 2018 Dec 4;38(1):71. Epub 2018 Dec 4.
Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, P. R. China.
Background: An increasing number of cancer patients die of cardiovascular diseases. The cardiotoxicity of chemotherapy is particularly important in triple-negative breast cancer (TNBC) with limited therapeutic options. Cardiac autophagy is an important mechanism of cardiotoxicity. Read More
BMC Cancer 2018 Dec 4;18(1):1203. Epub 2018 Dec 4.
Phyllis F. Cantor Center for Research in Nursing and Patient Care Services, Dana-Farber Cancer Institute, 450 Brookline Avenue, LW 518, Boston, MA, 02215, USA.
Background: Impaired physical function due to chemotherapy-induced peripheral neuropathy (CIPN) symptoms may lead to diminished quality of life. However, even with the knowledge of the effects of CIPN on physical function, clinicians infrequently assess and manage CIPN. Interventions that prioritize the early identification of CIPN to provide prompt treatment may reduce the impact of CIPN on physical function. Read More
BMC Cancer 2018 Dec 4;18(1):1211. Epub 2018 Dec 4.
Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Background: Breast neoplasms are the most common cancer among women in Taiwan. Cognitive deficits are common complications of breast cancer survivors treated with chemotherapy. The most frequently observed disorders involve executive function and memory impairment. Read More
Molecules 2018 Dec 3;23(12). Epub 2018 Dec 3.
Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Kuwait University, 13060 Kuwait.
Chemotherapy-induced nausea and vomiting (CINV) remain the most common and devastating side-effects associated with cancer chemotherapy. In recent decades, several lines of research emphasize the importance of 5-hydroxytryptamine3 (5-HT serotonin) receptors in the pathogenesis and treatment of CINV. 5-HT₃ receptors are members of ligand-gated ion channels that mediate the rapid and transient membrane-depolarizing effect of 5-HT in the central and peripheral nervous system. Read More
Front Oncol 2018 19;8:484. Epub 2018 Nov 19.
Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Department of Gastroenterology, Chongqing Cancer Institute, Chongqing University Cancer Hospital, Chongqing, China.
Chemotherapy-induced oral mucositis is an extremely serious complication faced by cancer patients. The role of oral zinc sulfate in preventing and treating chemotherapy-induced oral mucositis remains a subject of debate. The aim of this systematic review is to assess the potential of oral zinc sulfate to alleviate this morbid condition. Read More
Am J Nucl Med Mol Imaging 2018 20;8(5):303-310. Epub 2018 Oct 20.
Division of Nuclear Medicine, Department of Radiology, Saint Louis University 3635 Vista Ave, Saint Louis, MO 63110, USA.
This study aims to detect the potential impact of chemotherapy on the coronary calcium scoring (CCS) in lymphoma patients undergoing FDG-PET/CT at baseline and for therapy response using the CT portion of the exam to calculate the CCS. One hundred twelve lymphoma patients were included in the study based on having both baseline and at least 2 post-chemotherapy scans. The unenhanced CT portions of the scans were reviewed to measure the CCS which was then extracted using the Toshiba Vital Program. Read More
Cell Death Discov 2018 27;4:109. Epub 2018 Nov 27.
1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Aberrant lipid accumulation is a hallmark of cancer known to contribute to its aggressiveness and malignancy. Emerging studies have demonstrated context-dependent changes in lipid metabolism during chemotherapy. However, there is little known regarding the mechanisms linking lipid metabolism to chemotherapy-induced cell fates. Read More
Proc Natl Acad Sci U S A 2018 Dec 3. Epub 2018 Dec 3.
Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, China
Fibrous sheath interacting protein 1 (FSIP1) is a cancer antigen expressed in the majority of breast cancer tissues and is associated with poor prognosis. However, the role of FSIP1 in the progression and drug sensitivity of triple-negative breast cancer (TNBC) has not been explored. Here, we show that FSIP1 deficiency by shRNA-mediated knockdown or CRISPR-Cas9-mediated knockout significantly inhibits the proliferation and invasion of TNBC cells and impairs chemotherapy-induced growth inhibition in vivo. Read More
Pain Physician 2018 Nov;21(6):571-592
University of Texas, MD Anderson Cancer Center, Houston, TX.
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a commonly encountered disease entity following chemotherapy for cancer treatment. Although only duloxetine is recommended by the American Society of Clinical Oncology (ASCO) for the treatment of CIPN in 2014, the evidence of the clinical outcome for new pharmaceutic therapies and non-pharmaceutic treatments has not been clearly determined.
Objective: To provide a comprehensive review and evidence-based recommendations on the treatment of CIPN. Read More
Mol Pharmacol 2018 Nov 30. Epub 2018 Nov 30.
AM1710, a cannabilactone CB2 agonist, suppresses chemotherapy-induced neuropathic pain in rodents without producing tolerance or unwanted side effects associated with CB1 receptors. However, the signaling profile of AM1710 remains incompletely characterized. It is not known whether AM1710 behaves as a broad spectrum analgesic and/or suppresses the development of opioid tolerance and physical dependence. Read More
Future Oncol 2018 Nov 30. Epub 2018 Nov 30.
Utah Cancer Specialists, 5131 South Cottonwood Street, Suite 200, Murray, UT 84107, USA.
Aim: Chemotherapy-induced nausea and vomiting diminishes quality of life and increases healthcare resource use. This retrospective medical records analysis evaluated hydration requirements with emetogenic chemotherapy.
Patients & Methods: Cancer patients received moderately emetogenic chemotherapy (MEC) or highly emetogenic chemotherapy (HEC), and antiemetics palonosetron or granisetron extended-release subcutaneous (GERSC), neurokinin 1 receptor antagonist and dexamethasone. Read More
Curr Probl Cancer 2018 Nov 22. Epub 2018 Nov 22.
Department of Medical Oncology, Afyon Kocatepe University Faculty of Medicine, Afyon, Turkey.
Purpose: We aimed to investigate the compliance of Turkish Medical Oncologists to antiemetic guidelines for treatment of acute and delayed chemotherapy-induced nausea and vomiting (CINV) in patients receiving high (HEC), moderate (MEC), and low (LEC) emetogenic chemotherapy.
Method: A covering electronic mail letter with an online questionnaire link was sent to e-mail and mobile application groups including all 599 members of the Turkish Society of Medical Oncology in January 2018. The online survey has consisted of twelve questions. Read More
Support Care Cancer 2018 Nov 28. Epub 2018 Nov 28.
Department of Clinical Development, Acacia Pharma Ltd, Cambridge, UK.
Purpose: Chemotherapy-induced nausea and vomiting (CINV) remain significant clinical problems, especially in the delayed phase (24-120 h after chemotherapy). Amisulpride is a dopamine D/D-receptor antagonist previously shown to be an effective intravenous antiemetic. We conducted a randomised, double-blind study to characterise the dose response of oral amisulpride in delayed phase CINV. Read More
Breast Cancer Res 2018 Nov 28;20(1):146. Epub 2018 Nov 28.
Roswell Park Cancer Institute, Buffalo, NY, USA.
Background: The pathophysiology of chemotherapy-induced peripheral neuropathy (CIPN) is not well understood. Currently, dose reduction is the only recommendation for alleviating symptoms, often leading to premature treatment cessation. The primary aim of this analysis was to determine the association between components of diet during taxane treatment for breast cancer and change in CIPN symptoms over treatment. Read More
J Exp Clin Cancer Res 2018 Nov 28;37(1):293. Epub 2018 Nov 28.
College of Pharmacy and Medical Research Center, Chungbuk National University, Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju, Chungbuk, 28160, Republic of Korea.
Background: Interleukin-32 (IL-32) has been associated with various diseases. Previous studies have shown that IL-32 inhibited the development of several tumors. However, the role of IL-32γ, an isotype of IL-32, in skin carcinogenesis remains unknown. Read More
Eur J Cancer Care (Engl) 2018 Nov;27(6):e12921
MKA Breast Cancer Clinic, Tepe Prime, Ankara, Turkey.
ESC Heart Fail 2018 Nov 27. Epub 2018 Nov 27.
Department of Cardiovascular Medicine, Nara Medical University, Kashihara, Japan.
The index case was a 51-year-old woman suffering from doxorubicin cardiomyopathy. In her endomyocardial biopsy specimen, we observed under electron microscopy six scenes in which degenerative cardiomyocytes were engulfed by neighbouring cardiomyocytes. The enclosed cardiomyocytes appeared more degenerative than the enclosing ones in every pair: the myofibrils were more severely damaged. Read More
Sarcoma 2018 24;2018:2068517. Epub 2018 Oct 24.
MD Anderson Cancer Center, Sarcoma Medical Oncology, 1400 Holcombe Blvd, Unit 450, Houston, TX 77030, USA.
Histone deacetylase inhibitors (HDACi) can reverse chemoresistance, enhance chemotherapy-induced cytotoxicity, and reduce sarcoma proliferation in cell lines and animal models. We sought to determine the safety and toxicity of mocetinostat and its ability to reverse chemoresistance when administered with gemcitabine in patients with metastatic leiomyosarcoma resistant to prior gemcitabine-containing therapy. Participants with metastatic leiomyosarcoma received mocetinostat orally, 70 mg per day, three days per week, increasing to 90 mg after three weeks if well tolerated. Read More
Eur J Oncol Nurs 2018 Dec 19;37:23-28. Epub 2018 Oct 19.
Department of Nursing, Inha University, Incheon, Republic of Korea. Electronic address:
Purpose: The purpose of this study was to identify demographic, health- and cancer-related, and physiological factors associated with dexamethasone-induced intractable hiccups in cancer patients.
Method: This study adopted a retrospective case control design. The study subjects were 168 cancer patients admitted to a university hospital for chemotherapy between October 2011 and December 2016: 58 patients who experienced intractable hiccups while on dexamethasone (cases) and 110 matched patients who received dexamethasone but did not experience hiccups (controls). Read More
Cell Stem Cell 2018 Nov 7. Epub 2018 Nov 7.
Program in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, San Francisco, CA, USA; Department of Pediatrics and Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA. Electronic address:
The oral mucosa is one of the most rapidly dividing tissues in the body and serves as a barrier to physical and chemical insults from mastication, food, and microorganisms. Breakdown of this barrier can lead to significant morbidity and potentially life-threatening infections for patients. Determining the identity and organization of oral epithelial progenitor cells (OEPCs) is therefore paramount to understanding their roles in homeostasis and disease. Read More
J Pain 2018 Nov 21. Epub 2018 Nov 21.
Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address:
Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling condition accompanying several cancer drugs, including the front-line chemotherapeutic agent paclitaxel. Although CIPN can force dose reduction or even discontinuation of chemotherapy affecting survival in cancer patients, there is no FDA-approved treatment for CIPN. CIPN in mice is characterized by neuropathic pain (e. Read More
Oncologist 2018 Nov 23. Epub 2018 Nov 23.
Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
Background: Peripheral neuropathy is the dose-limiting toxicity of many oncology drugs, including paclitaxel. There is large interindividual variability in the neuropathy, and several risk factors have been proposed; however, many have not been replicated. Here we present a comprehensive study aimed at identifying treatment and physiopathology-related paclitaxel-induced neuropathy risk factors in a large cohort of well-characterized patients. Read More
Future Oncol 2018 Nov 23. Epub 2018 Nov 23.
Hospital Pharmacy, Pescara General Hospital, Pescara, 65124, Italy.
The aim of this retrospective study is to evaluate adherence, switch and costs a year after the start of treatment with different erythropoietin-stimulating agents. There were 277 patients, 200 were originators (72.20%) and 77 (27. Read More
Front Pharmacol 2018 8;9:1252. Epub 2018 Nov 8.
Department of Neurosciences, Psychology, Drug Research and Child Health (NeuroFarBa), University of Florence, Florence, Italy.
A prominent role of hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels has been suggested based on their expression and (dys)function in dorsal root ganglion (DRG) neurons, being likely involved in peripheral nociception. Using HCN blockers as antinociceptive drugs is prevented by the widespread distribution of these channels. However, tissue-specific expression of HCN isoforms varies significantly, HCN1 and HCN2 being considered as major players in DRG excitability. Read More
Oncol Rev 2018 Jul 18;12(2):359. Epub 2018 Oct 18.
Nursing and Midwifery Care Research Center, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.
Chemotherapy-induced peripheral neuropathy is a common adverse effect occurring in patients undergoing neurotoxic chemotherapy. However, there is no FDA-approved treatment option for it. Given the importance of clinical practice guidelines in this area, this study aimed to determine the methodological quality of extant CIPN guidelines. Read More
Nutrients 2018 Nov 20;10(11). Epub 2018 Nov 20.
Department of Pharmacy, University of Naples Federico II. Via Montesano 49, 80149 Naples, Italy.
Chemotherapy-induced alopecia (CIA) is a common side effect of conventional chemotherapy and represents a major problem in clinical oncology. Even months after the end of chemotherapy, many cancer patients complain of hair loss, a condition that is psychologically difficult to manage. CIA disturbs social and sexual interactions and causes anxiety and depression. Read More
Support Care Cancer 2018 Nov 20. Epub 2018 Nov 20.
University of Michigan School of Nursing, 400 North Ingalls, Ann Arbor, MI, 48109, USA.
Purpose: To test the psychometric properties of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Chemotherapy-Induced Peripheral Neuropathy (QLQ-CIPN20) using Rasch-based methods.
Methods: A secondary data analysis was performed using pooled QLQ-CIPN20 data from patients (N = 1008) who had participated in any of four multi-site chemotherapy-induced peripheral neuropathy (CIPN) treatment and prevention trials. QLQ-CIPN20 responses were evaluated using a polytomous Rasch partial credit model. Read More
Anim Cells Syst (Seoul) 2018 5;22(5):281-288. Epub 2018 Sep 5.
Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, South Korea.
Chemotherapy-induced bone marrow damage is accompanied by acute nerve injury in the bone marrow (BM), resulting in sensory and autonomic neuropathy. Cisplatin, a popular chemotherapy drugs, induces the impairment of hematopoietic stem cells (HSCs) and bone marrow regeneration, leading to chronic bone marrow abnormalities. Previously, we reported the protective roles of neuropeptide Y (NPY) against cisplatin-induced bone marrow impairment. Read More
J Neurosci 2018 Nov 20. Epub 2018 Nov 20.
University of Texas at Dallas, School of Behavioral and Brain Sciences.
Nociceptors, sensory neurons in the dorsal root ganglion (DRG) that detect damaging or potentially damaging stimuli, are key drivers of neuropathic pain. Injury to these neurons causes activation of translation regulation signaling including the mechanistic target of rapamycin complex 1 (mTORC1) and mitogen activated protein kinase interacting kinase (MNK) eukaryotic initiation factor (eIF) 4E pathways. This is a mechanism driving changes in excitability of nociceptors that is critical for the generation of chronic pain states, however, the mRNAs that are translated to lead to this plasticity have not been elucidated. Read More
Rev Recent Clin Trials 2018 Nov 19. Epub 2018 Nov 19.
Medical Oncology Unit, Fondazione Poliambulanza - Brescia. Italy.
Background: The most effective agents in the treatment of breast cancer have as common side effect the hair loss. Some studies reported a reduction of hair loss with the use of the scalp cooling device. Indeed, it decreases the drug accumulation in the hair follicles. Read More
Curr Clin Pharmacol 2018 Nov 19. Epub 2018 Nov 19.
Universiti Teknologi MARA, Faculty of Pharmacy, Bandar Puncak Alam, 42300 Selangor . Malaysia.
Background: Recombinant human keratinocyte growth factor (rHuKGF) has gained considerable attention by researchers as epithelial cells proliferating agent. Moreover, intravenous truncated rHuKGF (palifermin) has been approved by Food and Drug Administration (FDA) to treat and prevent chemotherapy-induced oral mucositis and small intestine ulceration. The labile structure and short circulation time of rHuKGF in-vivo are the main obstacles that reduce the oral bioactivity and dosage of such proteins at the target site. Read More
Pan Afr Med J 2018 5;30:198. Epub 2018 Jul 5.
Department of Pathology, University of Tunis El Manar, Tunis Faculty of Medicine, 1007, Tunisia.
Neoadjuvant chemotherapy of colorectal liver metastases can induce hepatotoxicity in noncancerous liver. The aim of the present study was to describe the chemotherapy-induced major changes in the hepatic parenchyma and their prognostic impact. We undertook a retrospective study of 48 cases of colorectal liver metastases treated with neoadjuvant therapy followed by liver resection. Read More
J Immunother Cancer 2018 Nov 19;6(1):123. Epub 2018 Nov 19.
Cancer Biology Research Platform, Centre Georges-François Leclerc, Dijon, France.
Background: T lymphocytes and HLA expression on tumor cell both influence prognostic of localized colorectal cancer, but their role following chemotherapy in patients with liver metastatic colorectal cancer (mCRC) was not addressed.
Methods: One hundred fourteen patients treated in curative intend of liver mCRC were included in this retrospective study. Patients were either untreated or treated with neoadjuvant therapy containing an anti-EGFR, bevacizumab or oxaliplatin. Read More
Clin J Oncol Nurs 2018 Dec;22(6):E146-E151
Scripps MD Anderson Cancer Center, Sanford Burnham Presbys Medical Discovery Institute, and Scripps Research Translational Institute.
Background: Hyperbaric oxygen therapy is a rare treatment modality for hemorrhagic cystitis (HC) following BK virus reactivation in the immunosuppressed population. Clinicians need to be aware of the etiology, preventive measures, complications, and various management techniques in HC while treating patients undergoing bone marrow transplantation.
Objectives: This study details the pathologic progression of HC in a patient with acute lymphoblastic leukemia harboring BK virus after cytotoxic induction chemotherapy and haploidentical marrow transplantation. Read More
Med J Armed Forces India 2018 Oct 1;74(4):358-364. Epub 2017 Sep 1.
Consultant, Department of Pathology, Apollo Gleneagles Hospital, Kolkata, India.
Background: is an emerging, opportunistic, pathogenic, zoonotic achlorophyllous green alga, expanding in pathogenicity and host range, causing localized and disseminated infections. This outbreak of algaemia and sepsis in a tertiary care 30-bedded chemotherapy oncology unit is the first human outbreak to the best of our knowledge.
Methods: algaemia was confirmed on consecutive isolation. Read More
Nutr Cancer 2018 Nov 17:1-10. Epub 2018 Nov 17.
c Department of Nutrition, School of Public Health , Iran University of Medical Sciences , Tehran , Iran.
Patients with breast cancer (PsBC) usually face with chemotherapy induced nausea and vomiting (CINV). The aim of this study was to assess the impact of nutritional counseling on CINV and quality of life (QoL) of PsBC. 150 PsBC were randomly assigned for receiving a personalized diet, which contained 1. Read More
Clin Breast Cancer 2018 Oct 23. Epub 2018 Oct 23.
Université Clermont Auvergne, Centre Jean Perrin, INSERM, U1240 Imagerie Moléculaire et Stratégies Théranostiques, Clermont-Ferrand, France.
Background: Young patients with breast cancer treated with chemotherapy can experience ovarian failure, which can lead to chemotherapy-induced menopause (CIM) impacting the quality of life (QoL). A prospective study was set out to evaluate the impact of CIM on QoL in women of childbearing age with non-metastatic breast cancer, and this article reports results of the interim analysis conducted to evaluate feasibility and to see preliminary results.
Patients And Methods: A total of 58 women (age, 18-46 years) with newly diagnosed breast cancer and treated with chemotherapy were eligible. Read More
Auris Nasus Larynx 2018 Nov 12. Epub 2018 Nov 12.
Division of Otolaryngology, Graduate School of Medicine, Kanazawa University, Kanazawa 920-8640, Japan.
Objectives: Cancer-related fatigue impairs daily functioning and negatively impacts health-related quality of life (HRQoL). Our previous study revealed that cisplatin-based chemoradiotherapy (CRT) impairs the carnitine system and carnitine deficiency leads to poor physical functioning. This open label, randomized, controlled prospective study investigated the effects of l-carnitine administration on plasma carnitine concentration, CRT-induced fatigue, and decline in HRQoL in patients with head and neck squamous cell carcinoma (HNSCC). Read More
Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:1-4
In this paper, we describe a novel portable test platform that can be used to test peripheral neuropathy either within a clinic or at home. The system, called the PeriVib, is comprised of (1) a small, custom vibration motor designed to apply a vibration stimulus to the toe with constant pressure to test sensation threshold, and (2) a custom smart-phone app that enables a patient to run a series of functional gait and balance tests. Vibration is applied by PeriVib in two separate modes. Read More
Neurosci Lett 2018 Nov 13;694:14-19. Epub 2018 Nov 13.
School of Medical Sciences, The University of New South Wales, Sydney, NSW, 2052, Australia. Electronic address:
Chemotherapy-induced peripheral neuropathy (CIPN) is a severe and debilitating adverse effect of cancer therapy that results from treatment with neurotoxic agents. Although chemotherapy treatment has been shown to inhibit neurite outgrowth from dorsal root ganglion (DRG) neurons in vitro, evidence for this effect in vivo is lacking. In this study, we investigated whether chemotherapy treatment in mice alters the capacity for axonal outgrowth from ex vivo cultured DRG explants. Read More
J Neurochem 2018 Nov 15. Epub 2018 Nov 15.
Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Painful peripheral neuropathy is a severe and difficult-to-treat neurological complication associated with cancer chemotherapy. Although chemotherapeutic drugs such as paclitaxel are known to cause tonic activation of presynaptic NMDA receptors (NMDARs) to potentiate nociceptive input, the molecular mechanism involved in this effect is unclear. α2δ-1, commonly known as a voltage-activated calcium channel subunit, is a newly discovered NMDAR-interacting protein and plays a critical role in NMDAR-mediated synaptic plasticity. Read More
Exp Neurobiol 2018 Oct 8;27(5):419-436. Epub 2018 Oct 8.
College of Veterinary Medicine and BK21Plus Project Team, Chonnam National University, Gwangju 61186, Korea.
Chemotherapeutic agents induce long-term side effects, including cognitive impairment and mood disorders, particularly in breast cancer survivors who have undergone chemotherapy. However, the precise mechanisms underpinning chemotherapy-induced hippocampal dysfunction remain unknown. In this study, we investigated the detrimental effects of chronic treatment with a combination of adriamycin and cyclophosphamide (AC) on the neuronal architecture and functions of the hippocampi of female C57BL/6 mice. Read More
Biosci Rep 2018 Nov 14. Epub 2018 Nov 14.
Department of the Second General Surgery, The Fourth Hospital, Hebei Medical University, shijiazhuang, China
Background And Aim: one of the treatment failures for colorectal cancer(CRC) is resistance to chemotherapy drugs. microRNAs (miRs) have been demonstrated to be a new regulator of pathobiological processes in various tumours. While, few studies have explored the specific role of microRNA-141(miR-141) in mediating 5-fluorouracil (5-FU) sensitivity of CRC cells. Read More
Eur J Haematol 2018 Nov 14. Epub 2018 Nov 14.
Faculty of Health and Medical Science, University of Copenhagen, Denmark.
Objective: Short telomere length is a known risk factor for developing clonal hematopoietic stem cell disorders, probably due to chromosomal instability. We tested the hypotheses that bone marrow mononuclear cell telomere length change from diagnosis through chemotherapy-induced remission and relapse, and that long telomere length is associated with low risk of relapse and all-cause mortality in patients with acute myeloid leukaemia or high-risk myelodysplastic syndrome.
Methods: We measured telomere length in bone marrow mononuclear cells from 233 patients at diagnosis, 112 patients at chemotherapy-induced remission and 58 patients at relapse of disease. Read More
Mol Pain 2018 Jan-Dec;14:1744806918816462. Epub 2018 Nov 14.
1 School of Nursing, University of California, San Francisco, San Francisco, CA, USA.
Background: Paclitaxel is one of the most commonly used drugs to treat breast cancer. Its major dose-limiting toxicity is paclitaxel-induced peripheral neuropathy (PIPN). PIPN persists into survivorship and has a negative impact on patient's mood, functional status, and quality of life. Read More