3,379 results match your criteria Chemotherapy[Journal]


Rare Case of Endoscopic Treatment for Bevacizumab-Related Gastric Perforation in a Patient with Ovarian Cancer.

Chemotherapy 2020 Jul 2:1-4. Epub 2020 Jul 2.

Università Cattolica del Sacro Cuore Facoltà di Medicina e Chirurgia, Rome, Italy.

Antiangiogenic chemotherapy is a common treatment option for patients with advanced ovarian cancer (OC) and has been proven to be effective and generally safe. Nevertheless, in rare cases, these drugs can give serious complications such as gastrointestinal perforations that can be even mortal or very difficult to treat and can heavily impact the clinical management. We present a rare case of bevacizumab-induced gastric perforation in a patient with advanced OC occurred during bevacizumab-including chemotherapy in an adjuvant setting. Read More

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http://dx.doi.org/10.1159/000508556DOI Listing

Sustained Complete Remission with Incomplete Hematologic Recovery (CRi) in a Patient with Relapsed AML and Concurrent BCR-ABL1 and CBFB Rearrangement Treated with a Combination of Venetoclax and 5-Azacytidine.

Chemotherapy 2020 Jun 22:1-3. Epub 2020 Jun 22.

Dipartimento Emato-Oncologia A.O. Pugliese-Ciaccio, S.O.C. Ematologia, Cantanzaro, Italy,

The co-occurrence of BCR-ABL1 fusion and core-binding factor (CBF) rearrangements is uncommonly reported in AML. Although CBF rearrangements carry a favorable prognosis, the coexistence of BCR-ABL1 is associated with aggressive disease suggesting a potential advantage of high-intensity chemotherapy in association with tyrosine kinase inhibitors. Herein, we describe a refractory AML patient harboring BCR-ABL1 fusion and CBFB rearrangement that was successfully treated with a combination of venetoclax and hypomethylating agent. Read More

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http://dx.doi.org/10.1159/000508658DOI Listing

Comparison of Platinum/S-1 and Platinum/5-Fluorouracil as First-Line Chemotherapy for Advanced Gastric or Gastroesophageal Junction Cancer: A Meta-Analysis Based on Randomized Controlled Trials.

Chemotherapy 2020 Jun 12:1-10. Epub 2020 Jun 12.

Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

Background: Platinum/S-1 (PS) and platinum/5-fluorouracil (PF) as first-line chemotherapies are extensively used for the treatment of advanced gastric or gastroesophageal junction cancer (AGC); however, there is no definite consensus on which regimen is best. In our meta-analysis, we compared PS with PF in terms of their efficacy and safety in AGC patients.

Methods: PubMed, ScienceDirect, Web of Science, Scopus, Ovid MEDLINE, EMBASE, The Cochrane Library, Google Scholar, and CNKI were systematically searched for pertinent literature. Read More

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http://dx.doi.org/10.1159/000506671DOI Listing

When Poisons Cure: The Case of Arsenic in Acute Promyelocytic Leukemia.

Chemotherapy 2020 Jun 10;64(5-6):1-10. Epub 2020 Jun 10.

Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy,

Arsenic has been known for centuries for its double-edged potential: a poison and at the same time a therapeutic agent. The name "arsenikon," meaning "potent," speaks itself for the pharmaceutical properties of this compound, questioned and analyzed for at least 2000 years. In the last decades, acute promyelocytic leukemia (APL) has evolved from a highly fatal to a curable disease, due to the use of all-trans-retinoic acid and, more recently, arsenic trioxide combinations. Read More

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http://dx.doi.org/10.1159/000507805DOI Listing

The First Report on Pharmacokinetic/Pharmacodynamic Study of Trimethoprim/Sulfamethoxazole against Staphylococcus aureus with a Neutropenic Murine Thigh Infection Model.

Chemotherapy 2020 May 20:1-9. Epub 2020 May 20.

Department of Clinical Infectious Diseases, Aichi Medical University, Aichi, Japan,

Introduction: With an increase in the incidence of Staphylococcus aureus infections in the healthcare settings and in the community, trimethoprim/sulfamethoxazole (TMP/SMX) has been suggested as a convenient treatment option. However, the appropriate dosage regimen of TMP/SMX is unclear.

Objective: This study aimed to examine the pharmacokinetics/pharmacodynamics (PK/PD) of TMP/SMX against S. Read More

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http://dx.doi.org/10.1159/000507540DOI Listing

Exploring the Role of Piperacillin and Tazobactam in Combination with Vancomycin against Methicillin-Resistant Staphylococcus aureus.

Chemotherapy 2020 May 12:1-5. Epub 2020 May 12.

Department of Pharmacy Practice and Administrative Sciences, University of New Mexico College of Pharmacy, Albuquerque, New Mexico, USA.

Previous studies have demonstrated synergy between piperacillin (PIP)-tazobactam (TAZ) (TZP) and vancomycin (VAN) against methicillin-resistant Staphylococcus aureus (MRSA). However, it is unknown whether PIP and/or TAZ synergizes with VAN against MRSA. We sought to determine whether PIP and/or TAZ synergizes with VAN against MRSA in vitro. Read More

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http://dx.doi.org/10.1159/000507241DOI Listing

Stereotactic Body Radiotherapy Combined with Transcatheter Arterial Chemoembolization versus Stereotactic Body Radiotherapy Alone as the First-Line Treatment for Unresectable Hepatocellular Carcinoma: A Meta-Analysis and Systematic Review.

Chemotherapy 2020 Apr 22:1-11. Epub 2020 Apr 22.

Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

Background: The superiority of stereotactic body radiotherapy (SBRT) combined with transcatheter arterial chemoembolization (TACE) compared to SBRT alone as the first-line therapy for unresectable hepatocellular carcinoma (HCC) remains unclear. We conducted this meta-analysis to compare the efficiency and safety of SBRT combined with TACE (ST group) and SBRT alone (SA group).

Methods: We searched PubMed, Ovid Medline, Web of Science, Scopus, The Cochrane Library, ScienceDirect, EMBASE, Google Scholar, and CNKI (China National Knowledge Infrastructure) for related studies. Read More

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http://dx.doi.org/10.1159/000505739DOI Listing
April 2020
1.554 Impact Factor

Utility of the Absolute Lymphocyte Count and Neutrophil/Lymphocyte Ratio for Predicting Survival in Patients with Metastatic Breast Cancer on Eribulin: A Real-World Observational Study.

Chemotherapy 2020 Apr 17:1-11. Epub 2020 Apr 17.

Division of Breast Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.

Introduction: Previous studies have suggested that the efficacy of eribulin is influenced by the activity of antitumor immunity of patients. Absolute lymphocyte count (ALC) and the neutrophil/lymphocyte ratio (NLR) are easily available parameters associated with the immunological status of patients.

Objective: Here we tried to classify patients' immunological status by using the scatter plot of ALC and NLR, and investigated its utility for predicting survival among patients with metastatic breast cancer receiving eribulin. Read More

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http://dx.doi.org/10.1159/000507043DOI Listing

COVID-19 Outbreak: An Overview.

Chemotherapy 2020 Apr 7:1-9. Epub 2020 Apr 7.

Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Rome, Italy.

Background: In late December 2019, Chinese health authorities reported an outbreak of pneumonia of unknown origin in Wuhan, Hubei Province.

Summary: A few days later, the genome of a novel coronavirus was released (http://viro-logical.org/t/novel-2019-coronavirus-genome/319; Wuhan-Hu-1, GenBank accession No. Read More

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http://dx.doi.org/10.1159/000507423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179549PMC

Knockdown of Kinesin Family 15 Inhibits Osteosarcoma through Suppressing Cell Proliferation and Promoting Cell Apoptosis.

Chemotherapy 2019 19;64(4):187-196. Epub 2020 Feb 19.

Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China,

Kinesin family (KIF) members have vital roles in mitosis, meiosis, and transport of macromolecules in eukaryotic cells. In this study, we aimed to investigate the role of KIF15 in osteosarcoma. Immunohistochemical staining was performed to determine expression levels of KIF15 in osteosarcoma tissues and adjacent normal tissues. Read More

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http://dx.doi.org/10.1159/000505014DOI Listing

Treatment of Pegylated Asparaginase-Induced Hypertriglyceridemia with Continuous Intravenous Infusion of Insulin and Heparin: A Case Report.

Chemotherapy 2019 11;64(4):210-214. Epub 2020 Feb 11.

Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden, Dresden, Germany.

Background: Pegylated asparaginase may induce prolonged hypertriglyceridemia. To date, there is no standard management of this complication. Here, we present a case report of pegylated asparaginase-induced hypertriglyceridemia and hepatotoxicity successfully treated with continuous intravenous infusion of insulin and heparin. Read More

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http://dx.doi.org/10.1159/000505773DOI Listing

Adherence to Adjuvant Imatinib Therapy in Patients with Gastrointestinal Stromal Tumor in Clinical Practice: A Cross-Sectional Study.

Chemotherapy 2019 17;64(4):197-204. Epub 2020 Jan 17.

Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China,

Background: Adherence to imatinib therapy has been significantly associated with disease progression and direct medical costs in gastrointestinal stromal tumor (GIST) patients. However, adherence to oral anticancer drugs is frequently hindered by the influence of various factors. The aim of this study was to evaluate the prevalence of imatinib adherence and its influencing factors among GIST patients in the adjuvant setting. Read More

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http://dx.doi.org/10.1159/000505177DOI Listing

Amoxicillin-Clavulanate Dosing in the Intensive Care Unit: The Additive Effect of Renal Replacement Therapy in a Patient with Normal Kidney Function.

Chemotherapy 2019 15;64(4):173-176. Epub 2020 Jan 15.

Departments of Pharmacy and Intensive Care, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.

Dosing of amoxicillin-clavulanic acid in critical illness is difficult as β-lactam pharmacokinetics are altered by physiological changes and therapies initiated in the intensive care unit such as renal replacement therapy (RRT). Successful treatment relies on sustaining a free antibiotic concentration above the minimum inhibitory concentration of the target pathogen (fT>MIC). We present a case of a patient treated with amoxicillin-clavulanic acid (1. Read More

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http://dx.doi.org/10.1159/000505057DOI Listing

Extracellular Histone Promotes Prostate Cancer Migration and Epithelial-Mesenchymal Transition through NF-κB-Mediated Inflammatory Responses.

Chemotherapy 2019 14;64(4):177-186. Epub 2020 Jan 14.

Department of Urology, The Affiliated Zhuzhou Hospital Xiangya Medical College CSU, ZhuZhou, China,

Introduction: This study aims to explore the relationship betweenextracellular histone and prostate cancer and its mechanism.

Methods: Migration of prostate cancer cells was detected by Transwell. Inflammatory factor expression was investigated by ELISA. Read More

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http://dx.doi.org/10.1159/000504247DOI Listing

Management of Ponatinib in Patients with Chronic Myeloid Leukemia with Cardiovascular Risk Factors.

Chemotherapy 2019 11;64(4):205-209. Epub 2019 Dec 11.

Hematology Division, University Hospital Policlinico "Paolo Giaccone", Palermo, Italy.

Cardiovascular (CV) adverse events are considered common complications of ponatinib treatment. Recently, it has been demonstrated that ponatinib dose reductions in definite settings can obtain optimal responses and lower ponatinib-related CV events. In this study, we describe the management of 5 patients with chronic myeloid leukemia treated with ponatinib, from second to fourth line of tyrosine kinase inhibitor therapy, carrying high pre-ponatinib CV risk, who obtained optimal molecular response and developed no CV adverse event during follow-up. Read More

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http://dx.doi.org/10.1159/000504664DOI Listing

Silencing of Proteasome 26S Subunit ATPase 2 Regulates Colorectal Cancer Cell Proliferation, Apoptosis, and Migration.

Chemotherapy 2019 12;64(3):146-154. Epub 2019 Nov 12.

Department of General Surgery, Changhai Hospital Affiliated to Navy Medical University, Shanghai, China,

Objective: Colorectal cancer (CRC) remains a major cause of cancer-related death worldwide. Proteasome 26S subunit ATPase 2 (PSMC2) plays vital roles in regulating cell cycle and transcription and has been confirmed to be a gene potentially associated with some human tumors. However, the expression correlation and molecular mechanism of PSMC2 in CRC are still unclear. Read More

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http://dx.doi.org/10.1159/000502224DOI Listing
December 2019

Safety and Efficacy of Bendamustine Monotherapy in the First-Line Treatment of Patients with Chronic Lymphocytic Leukemia: Polish Lymphoma Research Group Real-Life Analysis.

Chemotherapy 2019 12;64(3):155-162. Epub 2019 Nov 12.

Department of Clinical Transplantology, Medical University of Lublin, Lublin, Poland.

Bendamustine is a cytostatic drug with a unique structure, combining the features of purine nucleoside analogs and alkylating agents. In patients with chronic lymphocytic leukemia (CLL) it is commonly used in combination with rituximab (BR protocol) both in the first-line as well as subsequent lines of therapy, and in clinical trials it is often combined with new targeted therapies. Therefore, the data on its real-life safety and efficacy are of clinical significance. Read More

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http://dx.doi.org/10.1159/000503220DOI Listing
December 2019

Emergence of Carbapenem-Hydrolyzing Oxacillinases in Acinetobacter baumannii in Children from Croatia.

Chemotherapy 2019 8;64(4):167-172. Epub 2019 Nov 8.

School of Medicine, University of Zagreb, Zagreb, Croatia.

Introduction: Carbapenem resistance in Acinetobacter baumannii can be mediated by carbapenemases of class A, class B metallo-β-lactamases (MBLs), and class D carbapenem-hydrolyzing oxacillinases (CHDL). The aim of the study was to investigate the antimicrobial susceptibility and β-lactamase production of carbapenem-resistant A. baumannii isolates (CRAB) from the Children's Hospital Zagreb, Croatia. Read More

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http://dx.doi.org/10.1159/000503746DOI Listing

TRIAP1 Inhibition Activates the Cytochrome c/Apaf-1/Caspase-9 Signaling Pathway to Enhance Human Ovarian Cancer Sensitivity to Cisplatin.

Authors:
Tian-Mei Zhang

Chemotherapy 2019 29;64(3):119-128. Epub 2019 Oct 29.

Department of Gynecology, YanTaiShan Hospital, YanTai City, China,

Objective: To investigate whether TRIAP1inhibition affects the ovarian cancer cell resistance to cisplatin (DDP) via the Cyt c/Apaf-1/caspase-9 pathway by in vitro and in vivo experiments.

Methods: CCK8 assay was performed to find out how treatment with both TRIAP1 siRNA and DDP affects the cell viability of SKOV3 cells and DDP-resistant human ovarian carcinoma cell line SKOV3/DDP. SKOV3/DDP cells were transfected with control siRNA or TRIAP1 siRNA before 24 h of treatment with DDP (5 μg/mL). Read More

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http://dx.doi.org/10.1159/000501633DOI Listing
December 2019

Increase in Carbohydrate Antigen 19-9 Levels without Tumor Progression after Polaprezinc Administration that Induced Deep Vein Thrombosis in a Colon Cancer Patient.

Chemotherapy 2019 25;64(3):163-166. Epub 2019 Oct 25.

Department of Surgery, Saiseikai Hyogo Hospital, Kobe, Japan.

Carbohydrate antigen 19-9 (CA 19-9) is a well-known tumor marker of adenocarcinoma (reference range, 37 U/mL). It can also be used, together with computed tomography, to monitor responses and resistance to chemotherapy in cancer patients. False elevation of CA 19-9 levels is often seen in conditions such as biliary tract obstruction and cholangitis. Read More

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http://dx.doi.org/10.1159/000503221DOI Listing
December 2019
1 Read

Effects of Glutathione Transferase-Targeting Nitrobenzoxadiazole Compounds in Relation to PD-L1 Status in Human Melanoma Cells.

Chemotherapy 2019 22;64(3):138-145. Epub 2019 Oct 22.

Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy,

Background: PD-L1 is a membrane protein with inhibitory effects on immune responses, whose expression has been correlated with high aggressiveness and the propensity of melanoma to metastasize. The nitrobenzoxadiazole (NBD) NBDHEX and its analog MC3181 are endowed with strong antitumor activity towards melanoma and a significant ability to reduce its adhesion and invasiveness. Therefore, we investigated whether PD-L1 status could affect cell sensitivity to the cytotoxic effects of NBDs. Read More

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http://dx.doi.org/10.1159/000503339DOI Listing
December 2019

Modified Glasgow Prognostic Score as a Prognostic Factor in Patients with Extensive Disease-Small-Cell Lung Cancer: A Retrospective Study in a Single Institute.

Chemotherapy 2019 17;64(3):129-137. Epub 2019 Oct 17.

Department of Comprehensive Cancer Therapy, Shinshu University School of Medicine, Matsumoto City, Japan,

Introduction: Small-cell lung cancer (SCLC) is a very chemosensitive solid tumor but is characterized by rapid progression. The modified Glasgow prognostic score (mGPS) has been shown to be an independent prognostic factor in various tumors. However, there have been few reports regarding the prognostic value of mGPS in extensive disease (ED)-SCLC. Read More

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http://dx.doi.org/10.1159/000502681DOI Listing
December 2019
2 Reads

Pharmacokinetics of Total and Unbound Cefazolin during Veno-Arterial Extracorporeal Membrane Oxygenation: A Case Report.

Chemotherapy 2019 14;64(3):115-118. Epub 2019 Oct 14.

University of Queensland Centre of Clinical Research, Faculty of Medicine, The University of Queensland, Herston, Queensland, Australia.

Extra-corporeal membrane oxygenation (ECMO) therapy could affect effective drug concentrations via adsorption onto the oxygenator or associated circuit. We describe a case of a 25-year-old female who required a veno-arterial ECMO therapy for refractory cardiac arrest due to massive pulmonary embolism. She had mild renal dysfunction as a result of the cardiac arrest. Read More

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http://dx.doi.org/10.1159/000502474DOI Listing
December 2019
1 Read

Effectiveness and Safety of Combination Therapy of Transarterial Chemoembolization and Apatinib for Unresectable Hepatocellular Carcinoma in the Chinese Population: A Meta-Analysis.

Chemotherapy 2019 30;64(2):94-104. Epub 2019 Sep 30.

Department of Epidemiology, School of Public Health, The Fourth Military Medical University, Xi'an, China,

Background: The combination of transarterial chemoembolization (TACE) and apatinib has been used in the treatment of intermediate or advanced hepatocellular carcinoma (HCC). However, its effectiveness and safety are also argued.

Methods: Eligible studies were collected from a computer search of literatures published from the database establishment to May 2019 in PubMed, Web of Science, EMBASE, Ovid, the Cochrane Library, Wanfang Database, China National Knowledge Infrastructure, and China Biology Medicine Disc. Read More

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http://dx.doi.org/10.1159/000502510DOI Listing
November 2019
4 Reads
1.554 Impact Factor

Pomalidomide-Responsive Extramedullary Myeloma Relapsed after Allogeneic Hematopoietic Transplant and Refractory to Multiple Lines of Chemotherapy.

Chemotherapy 2019 18;64(2):110-114. Epub 2019 Sep 18.

Divisione di Ematologia - Ospedale Policlinico, Catania, Italy.

Patients who experience extramedullary relapses (EMR) of multiple myeloma (MM) have an adverse prognosis, also in this era of novel agents like proteasome inhibitors and immunomodulatory drugs. We describe the case of an MM patient with EMR at 2 different sites after allogeneic stem cell transplantation. EMR was refractory to bortezomib, anthracycline, and bendamustine, but the patient achieved long-term complete remission (4 years) with pomalidomide and dexamethasone. Read More

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http://dx.doi.org/10.1159/000502473DOI Listing
November 2019
5 Reads

Successful Treatment of Severe Aspergillosis with Isavuconazole Therapy after Allogeneic Stem Cell Transplantation.

Chemotherapy 2019 4;64(2):57-61. Epub 2019 Sep 4.

Department of Hematology, Hospital General Universitario Gregorio Marañon, Madrid, Spain.

Invasive fungal infections are one of the main infectious complications in allogeneic stem cell transplantation (SCT). Triazoles (voriconazole, posaconazole) are the main prophylactic and therapeutic options for the treatment of invasive aspergillosis. However, pharmacological interactions and hepatotoxicity limit its use. Read More

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http://dx.doi.org/10.1159/000502279DOI Listing
November 2019
2 Reads

Use of Cardioprotective Dexrazoxane Is Associated with Increased Myelotoxicity in Anthracycline-Treated Soft-Tissue Sarcoma Patients.

Chemotherapy 2019 7;64(2):105-109. Epub 2019 Aug 7.

Department of Medical Oncology, Università Campus Bio-Medico, Rome, Italy,

Background: Dexrazoxane (DEX) is indicated as a cardioprotective agent for breast cancer patients receiving the anthracycline doxorubicin. Two meta-analyses in metastatic breast cancer reported an apparent increase in the severity of myelosuppression when DEX was used. So far, no data in soft-tissue sarcoma (STS) patients are available. Read More

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http://dx.doi.org/10.1159/000501195DOI Listing
November 2019
2 Reads

Treatment Selection for Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia in the Era of Tyrosine Kinase Inhibitors.

Chemotherapy 2019 7;64(2):81-93. Epub 2019 Aug 7.

Hematology Department, State Key Laboratory of Trauma, Burns and Combined Injury, Xinqiao Hospital of Army Medical University, Chongqing, China,

With the advent of tyrosine kinase inhibitors (TKIs), the treatment of Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) has entered a new era. The efficacy of TKIs compared with other ALL treatment options is emphasized by a rapid increase in the number of TKI clinical trials. Subsequently, the use of traditional approaches, such as combined chemotherapy and even allogeneic hematopoietic stem cell transplantation (allo-HSCT), for the treatment of ALL is being challenged in the clinic. Read More

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https://www.karger.com/Article/FullText/501061
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http://dx.doi.org/10.1159/000501061DOI Listing
November 2019
3 Reads

On the Horizon: Targeting Next-Generation Immune Checkpoints for Cancer Treatment.

Chemotherapy 2019 6;64(2):62-80. Epub 2019 Aug 6.

Laboratory of Molecular Oncology, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome, Italy.

Background: Immune checkpoints are critical regulatory pathways of the immune system which finely tune the response to biological threats. Among them, the CD-28/CTLA-4 and PD-1/PD-L1 axes play a key role in tumour immune escape and are well-established targets of cancer immunotherapy.

Summary: The clinical experience accumulated to date provides unequivocal evidence that anti-CTLA-4, PD-1, or PD-L1 monoclonal antibodies, used as monotherapy or in combination regimes, are effective in a variety of advanced/metastatic types of cancer, with improved clinical outcomes compared to conventional chemotherapy. Read More

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http://dx.doi.org/10.1159/000500902DOI Listing
November 2019

Efficacy and Safety of Cetuximab plus Radiotherapy in Cisplatin-Unfit Elderly Patients with Advanced Squamous Cell Head and Neck Carcinoma: A Retrospective Study.

Chemotherapy 2019 26;64(1):48-56. Epub 2019 Jun 26.

Department of Translational Medical Sciences, School of Medicine, University of Campania "L. Vanvitelli", Naples, Italy.

Introduction: Concurrent platinum-based chemoradiation currently represents the standard treatment for advanced head and neck cancer (HNC), but it induces a significant toxicity, in particular among elderly patients. Elderly and unfit patients have been underrepresented in clinical trials and there is a need for tailored guidelines.

Methods: A retrospective review of clinical data of HNC patients treated at the Operative Oncology Unit of the San Giovanni di Dio Hospital in Frattamaggiore (Naples, Italy) was performed. Read More

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http://dx.doi.org/10.1159/000500714DOI Listing
July 2019
6 Reads

Essential Oils for the Treatment of Herpes Simplex Virus Infections.

Authors:
Paul Schnitzler

Chemotherapy 2019 24;64(1):1-7. Epub 2019 Jun 24.

Center for Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany,

Infections with herpes simplex virus type (HSV)-1 and HSV-2 are distributed worldwide. Although standard therapies with acyclovir and other synthetic drugs are available, the safety and efficacy of these drugs are limited due to the development of drug resistance and adverse side effects. The literature on essential oils and isolated compounds was reviewed regarding their antiviral activities against HSV-1 and HSV-2. Read More

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http://dx.doi.org/10.1159/000501062DOI Listing
July 2019
16 Reads

Inhibition of Pantothenate Synthetase by Analogs of β-Alanine Precursor Ineffective as an Antibacterial Strategy.

Chemotherapy 2019 5;64(1):22-27. Epub 2019 Jun 5.

Krembil Research Institute, University Health Network, Toronto, Ontario, Canada,

Background: Pantothenate, the fundamental precursor to coenzyme A, is required for optimal growth and virulence of microbial pathogens. It is synthesized by the enzyme-catalyzed condensation of β-alanine and pantoate, which has shown susceptibility to inhibition by analogs of its molecular constituents. Accordingly, analogs of β-alanine are gaining inquiry as potential antimicrobial chemotherapeutics. Read More

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http://dx.doi.org/10.1159/000499899DOI Listing
July 2019
4 Reads

Pharmacokinetics of Benzylpenicillin (Penicillin G) during Prolonged Intermittent Renal Replacement Therapy.

Chemotherapy 2019 5;64(1):17-21. Epub 2019 Jun 5.

University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia,

Prolonged intermittent renal replacement therapy (PIRRT) is an increasingly adopted method of renal replacement in critically ill patients. Like continuous renal replacement therapy, PIRRT can alter the pharmacokinetics (PK) of many drugs. In this setting, dosing data for antibiotics like benzylpenicillin are lacking. Read More

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https://www.karger.com/Article/FullText/499375
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http://dx.doi.org/10.1159/000499375DOI Listing
July 2019
51 Reads

Efficacy of Combination Therapy with Actinomycin D and Methotrexate in the Treatment of Low-Risk Gestational Trophoblastic Neoplasia.

Chemotherapy 2019 4;64(1):42-47. Epub 2019 Jun 4.

Gynecologic Department, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China,

Objectives: We aimed to identify an optimal regimen for low-risk gestational trophoblastic neoplasia (LR-GTN) providing reduction in dosage and toxicity/side effects, enhancement of therapeutic efficacy, and a shorter treatment duration.

Methods: A total of 149 LR-GTN patients were enrolled in the affiliated Beijing Maternity Hospital of Capital Medical University from January 2014 to January 2017 and randomly divided into 3 groups with 50 cases in the methotrexate (MTX) group, 49 in actinomycin D (ACT-D) group, and 50 in ACT-D+MTX group. Follow-up recorded symptoms, physical and bimanual gynecological examinations, routine blood test, serum β-HCG level, liver and renal functions, electrolytes, electrocardiogram before each treatment course, and pelvic and abdominal B-mode ultrasound or pelvic/abdominal/chest computed tomography. Read More

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http://dx.doi.org/10.1159/000500165DOI Listing
July 2019
19 Reads

Gonadal Function Recovery and Fertility in Women Treated with Chemo- and/or Radiotherapy for Hodgkin's and Non-Hodgkin Lymphoma.

Chemotherapy 2019 22;64(1):36-41. Epub 2019 May 22.

Unit of Hematology, AUO Ospedali Riuniti, Università Politecnica delle Marche, Ancona, Italy.

Background: Fertility and gonadal function represent one of the most important aspects for long-term lymphoma survivors.

Aims: The aim of our study was to determine possible risk factors, such as age at treatment, chemotherapeutic regimen, protection with oral contraceptives (OCs), and gonadotropin-releasing hormone (GnRH) analogues in female patients treated for Hodgkin's lymphoma (HL) or non-Hodgkin lymphoma (NHL) at a reproductive age.

Methods: Patients between the age of 16 and 50 years at the time of HL or NHL diagnosis were selected. Read More

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http://dx.doi.org/10.1159/000499535DOI Listing
July 2019
6 Reads

Levofloxacin for NIH Category II Chronic Bacterial Prostatitis: A Real-Life Study.

Chemotherapy 2019 21;64(1):8-16. Epub 2019 May 21.

Department of Urology, University of Milan-Ca' Granda Foundation, Ospedale Maggiore Policlinico, Milan, Italy.

Background: Mounting worldwide resistance trends make the use of fluoroquinolone (FQ) antibacterial agents increasingly difficult. This is felt more acutely in the case of urogenital infections, which are mainly caused by Gram-negative pathogens. For years, levofloxacin and other FQs have been the first-line drugs for treating National Institutes of Health (NIH) category II chronic bacteria prostatitis (CBP). Read More

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https://www.karger.com/Article/FullText/499034
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http://dx.doi.org/10.1159/000499034DOI Listing
July 2019
22 Reads
1.554 Impact Factor

IL1RN Polymorphisms Are Associated with a Decreased Risk of Esophageal Cancer Susceptibility in a Chinese Population.

Chemotherapy 2019 17;64(1):28-35. Epub 2019 Apr 17.

Department of Radiotherapy, Shaanxi Provincial Cancer Hospital Affiliated to Medical College, Xi'an Jiaotong University, Xi'an, China,

Background: Recent evidence suggested that IL1RN (interleukin-1 receptor antagonist) polymorphisms increased the susceptibility to cancers. The present study aimed to evaluate whether IL1RN was related to esophageal cancer susceptibility in a Northwest Han Chinese population.

Methods: The case-control study was conducted on 384 esophageal cancer patients and 499 healthy controls. Read More

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http://dx.doi.org/10.1159/000496400DOI Listing
July 2019
5 Reads

Cancer Therapy-Related Cardiac Dysfunction: Are We Treating Echocardiograms, Patients, Neither, or Both?

Chemotherapy 2018 9;63(6):338-339. Epub 2019 Apr 9.

Cardiocenter and Unit of Cardiology, University Campus Bio-Medico of Rome, Rome, Italy,

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http://dx.doi.org/10.1159/000496612DOI Listing
May 2019
2 Reads

Does the Beta-Lactam Matter? Nafcillin versus Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bloodstream Infections.

Chemotherapy 2018 9;63(6):345-351. Epub 2019 Apr 9.

University of Minnesota College of Pharmacy, Minneapolis, Minnesota, USA,

Background: Antistaphylococcal penicillins have historically been regarded as the drugs of choice for methicillin-susceptible Staphylococcus aureus (MSSA) bloodstream infections (BSI). However, recent outcomes data compared to cefazolin treatment are conflicting.

Objective: This study compared treatment failure and adverse effects associated with nafcillin and cefazolin for MSSA BSI. Read More

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http://dx.doi.org/10.1159/000499033DOI Listing
May 2019
5 Reads

Osteolytic Lesions in Primary Myelofibrosis and Effect of Ruxolitinib Therapy: Report of a Case and Literature Review.

Chemotherapy 2018 9;63(6):340-344. Epub 2019 Apr 9.

Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy,

Here, we report the case of a young female affected by primary myelofibrosis (PMF) who developed an osteolytic lesion of the humerus during the follow-up, and the possible efficacy of ruxolitinib in controlling this rare event. After 26 years of follow-up, the patient reported onset of acute pain at the proximal region of the left upper limb. An X-ray revealed an osteolytic bone lesion in the proximal third of the humeral shaft, which was then confirmed by magnetic resonance imaging. Read More

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http://dx.doi.org/10.1159/000497246DOI Listing
May 2019
9 Reads

Comparative Emergence of Resistance to Clofoctol, Erythromycin, and Amoxicillin against Community-Acquired Bacterial Respiratory Tract Pathogens in Italy.

Chemotherapy 2018 25;63(6):330-337. Epub 2019 Mar 25.

Postgraduate School of Clinical Pharmacology and Toxicology, University of Milan, Milan, Italy.

Due to increasing bacterial resistance and poor availability of new antibiotics, physicians need to use old, still active antibiotics more frequently. In this study, we focused on clo-foctol and aimed to verify the emergence of clofoctol resistance over time. Additionally, the ability of clofoctol to induce resistance under static and dynamic conditions was evaluated. Read More

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http://dx.doi.org/10.1159/000496931DOI Listing
May 2019
5 Reads

False Positive Cardiotoxicity Events in Cancer-Related Clinical Trials: Risks Related to Imperfect Noninvasive Parameters.

Chemotherapy 2018 7;63(6):324-329. Epub 2019 Mar 7.

Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Purpose: Cardiac ultrasound provides important structural and functional information that makes identification of cardiac abnormalities possible. Left ventricular ejection fraction (LVEF) provides the most commonly used parameter for recognition of treatment-related cardiac dysfunction. Random reading variance and physiologic factors influence LVEF and make the reported value imperfect. Read More

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http://dx.doi.org/10.1159/000495147DOI Listing
May 2019
2 Reads

Use of Rifabutin as an Alternative Agent for Human Brucellosis: A Case Report.

Chemotherapy 2018 7;63(6):321-323. Epub 2019 Mar 7.

Department of Infectious Diseases and Clinical Microbiology, Sakarya University Faculty of Medicine, Sakarya, Turkey.

Drugs that have a good intracellular passage are used in the treatment of brucellosis. According to our knowledge, there is no report in English about rifabutin usage in brucellosis. We present a case that developed intolerance to many anti-brucella drugs, who was then successfully treated with a combination of rifabutin, ofloxacin, and ceftriaxone. Read More

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http://dx.doi.org/10.1159/000495216DOI Listing
May 2019
1 Read

Overexpression of TEL-MN1 Fusion Enhances Resistance of HL-60 Cells to Idarubicin.

Chemotherapy 2018 6;63(6):308-314. Epub 2019 Mar 6.

Department of Hematology, Institute of Hematology, Changhai Hospital, Second Military Medical University, Shanghai, China,

Background: The translocation t(12; 22) (p13;q12) is a recurrent but infrequent chromosome abnormality in human myeloid malignancies. To date, the role of TEL-MN1 fusion in leukemogenic process and drug resistance is still largely unknown.

Methods: In the present study, the TEL-MN1 fusion was transfected into HL-60 cells to upregulate TEL-MN1 expression via a retroviral vector. Read More

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http://dx.doi.org/10.1159/000495073DOI Listing
May 2019
19 Reads

Ivabradine in Cancer Treatment-Related Left Ventricular Dysfunction.

Chemotherapy 2018 6;63(6):315-320. Epub 2019 Mar 6.

Cardiovascular Disease Unit, San Martino Policlinic Hospital, Genoa, Italy,

Background: Patients developing cancer treatment-related left ventricular dysfunction (CTrLVD) require a prompt therapy. Hypotension, dizziness, and fatigue often limit the use of angiotensin-converting enzyme inhibitors (ACEi), angiotensin receptor blockers (ARB), and β-blockers (BB) in cancer patients who may already be afflicted by these symptoms. Ivabradine is a heart rate-lowering drug that does not cause hypotension and may be used in heart failure with reduced left ventricular ejection fraction (LVEF). Read More

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http://dx.doi.org/10.1159/000495576DOI Listing
May 2019
4 Reads

Relative Factors Analysis of Imatinib Trough Concentration in Chinese Patients with Gastrointestinal Stromal Tumor.

Chemotherapy 2018 5;63(6):301-307. Epub 2019 Mar 5.

Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China,

Aims: Imatinib plasma trough levels (IM Cmin) have been reported to have a considerable clinical impact in patients with gastrointestinal stromal tumors (GISTs). We therefore have investigated the factors affecting IM plasma concentration in Chinese GIST patients.

Methods: IM Cmin in 190 patients with GIST who were taking IM were measured. Read More

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http://dx.doi.org/10.1159/000493195DOI Listing
May 2019
6 Reads
1.554 Impact Factor

Ginsenoside-Rg5 Inhibits Retinoblastoma Proliferation and Induces Apoptosis through Suppressing BCL2 Expression.

Chemotherapy 2018 7;63(5):293-300. Epub 2019 Feb 7.

Record Room, Jinan Second People's Hospital, Jinan, China,

Background/aims: Although the cure rate for retinoblastoma is high, surviving patients are at risk for developing secondary cancers and require life-long follow-up. It is imperative to discover and develop novel therapeutic agents with better efficiency and fewer adverse effects. Ginsenoside-Rg5 is an active derivate from ginseng and exerts anti-cancer activity in breast cancer cells. Read More

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http://dx.doi.org/10.1159/000495575DOI Listing
March 2019
2 Reads

Selective MMP Inhibition, Using AZD3342, to Reduce Gastrointestinal Toxicity and Enhance Chemoefficacy in a Rat Model.

Chemotherapy 2018 7;63(5):284-292. Epub 2019 Feb 7.

Discipline of Physiology, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.

Background: The common cytotoxic mechanisms that underpin chemoefficacy and toxicity have hampered efforts to deliver effective supportive care interventions, particularly for gastrointestinal (GI) toxicity. Matrix metalloproteinases (MMPs) have been implicated in both tumor growth and GI toxicity, and as such MMP inhibitors present as a novel therapeutic avenue to simultaneously enhance treatment efficacy and reduce toxicity.

Objectives: The aim of this study was to determine the efficacy of an MMP-9/12 inhibitor, AZD3342, on tumor growth and GI toxicity in a rat model. Read More

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http://dx.doi.org/10.1159/000495470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425820PMC
March 2019
4 Reads

Combining Tumor-Selective Bacterial Therapy with Salmonella typhimurium A1-R and Cancer Metabolism Targeting with Oral Recombinant Methioninase Regressed an Ewing's Sarcoma in a Patient-Derived Orthotopic Xenograft Model.

Chemotherapy 2018 23;63(5):278-283. Epub 2019 Jan 23.

AntiCancer Inc., San Diego, California, USA,

Background: Ewing's sarcoma (ES) is a recalcitrant disease in need of transformative therapeutics.

Objectives: The aim of this study was to investigate the efficacy of tumor-selective Salmonella typhimurium A1-R combined with tumor metabolism targeting with oral administration of recombinant methioninase (o-rMETase), on an ES patient-derived orthotopic xenograft (PDOX) model.

Methods: The ES PDOX models were previously established in the right chest wall. Read More

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http://dx.doi.org/10.1159/000495574DOI Listing
March 2019
12 Reads

Recurrent Episodes of Nivolumab-Induced Pneumonitis after Nivolumab Discontinuation and the Time Course of Carcinoembryonic Antigen Levels: A Case of a 58-Year-Old Woman with Non-Small Cell Lung Cancer.

Chemotherapy 2018 20;63(5):272-277. Epub 2018 Dec 20.

Department of Pulmonology, St. Antonius Hospital, Nieuwegein, The Netherlands,

Introduction: The introduction of immune checkpoint inhibitors heralded a new era in the treatment of non-small cell lung cancer. However, nivolumab, an anti-PD-1 antibody, can cause serious adverse events that are mostly autoimmune related.

Case Presentation: A 58-year-old woman was treated with nivolumab as second-line therapy for stage IV adenocarcinoma. Read More

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http://dx.doi.org/10.1159/000494841DOI Listing