Cancer Lett 2020 03 10;472:1-7. Epub 2019 Dec 10.
Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain; Center for Biomedical Network Research on Rare Diseases (CIBERER), Madrid, Spain; Sant Pau Biomedical Research Institute, Sant Pau Hospital, Barcelona, Spain; Department of Genetics, Sant Pau Hospital, Barcelona, Spain. Electronic address:
Fanconi anemia (FA) is a rare genome instability syndrome characterized by progressive bone marrow failure and predisposition to cancer, especially head and neck squamous cell carcinoma. Surgical resection is the standard of care for solid tumors, as patients with FA do not tolerate genotoxic chemotherapies or radiation, leading to poor prognosis. It is therefore imperative to develop chemoprevention strategies such as the identification of novel biomarkers to detect the formation of the tumor before its emergence and to use them in clinical trials aimed to counteract genome instability of patients with FA in tissues at risk. Read More