150 results match your criteria Chemoprevention Strategies in Head and Neck Cancer


Oxethazaine inhibits esophageal squamous cell carcinoma proliferation and metastasis by targeting aurora kinase A.

Cell Death Dis 2022 02 25;13(2):189. Epub 2022 Feb 25.

Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450000, Henan, China.

Esophageal squamous cell carcinoma (ESCC), a malignant neoplasm with high incidence, is a severe global public health threat. The current modalities used for treating ESCC include surgery, chemotherapy, and radiotherapy. Although ESCC management and treatment strategies have improved over the last decade, the overall 5-year survival rate remains <20%. Read More

View Article and Full-Text PDF
February 2022

Impact of the practical guideline on appropriate usage of antimicrobial treatments for surgical site infections in reconstructive surgery of head and neck cancer.

J Infect Chemother 2022 Mar 6;28(3):401-405. Epub 2021 Dec 6.

Department of Otorhinolaryngology Head and Neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama-shi, Wakayama, 641-8510, Japan. Electronic address:

Objectives: In 2016, Japanese Society of Chemotherapy and Japan Society for Surgical Infection presented the practical guideline for appropriate usage of antimicrobial agents to prevent postoperative infections. This study aims to exhibit the validity of the guideline as a series of effective strategies for prevention of surgical site infections (SSIs) during reconstructive surgery of the head and neck cancer.

Methods: We retrospectively evaluated patients who underwent head and neck reconstructive surgery with free or pedicle flaps in a single institute in Japan between July 2010 and July 2020. Read More

View Article and Full-Text PDF

mTOR inhibitor PP242 increases antitumor activity of sulforaphane by blocking Akt/mTOR pathway in esophageal squamous cell carcinoma.

Mol Biol Rep 2022 Jan 3;49(1):451-461. Epub 2021 Nov 3.

State Key Laboratory of Esophageal Cancer Prevention & Treatment, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.

Background: Sulforaphane (SFN) is a kind of isothiocyanate from cruciferous vegetables with extensive anti-tumor activity. Esophageal squamous cell carcinoma (ESCC) is a popular malignancy in East Asia, East and South Africa, while the more efficient medicines and therapeutic strategies are still lack. This study aims to explore the anti-tumor activity of SFN alone and combined with Akt/mTOR pathway inhibitors as well as the potential molecular mechanism in ESCC. Read More

View Article and Full-Text PDF
January 2022

A Systematic Review of Potential Immunotherapies Targeting PRAME in Retinoid Resistant Oral Potentially Malignant Disorders and Oral Cancer.

Curr Mol Med 2022 ;22(8):735-746

DHR MRU, King George's Medical University, Lucknow, Uttar Pradesh, India.

Backgound and objective: Early chemoprevention in Oral Potentially Malignant Disorders (OPMDs) and Oral Cancer (OC) has been extensively researched in order to mitigate the malignant transformation and progression of the lesion. Many agents have been attempted, but their cost inefficacy and inadequate outcomes posed a major hindrance in their successful adoption. Retinoid Based Therapy (RBT) though a cheap and effective treatment option, could not achieve much clinical usage because of variable responsiveness in clinical outcomes. Read More

View Article and Full-Text PDF

Early-Phase Interventional Trials in Oral Cancer Prevention.

Cancers (Basel) 2021 Jul 30;13(15). Epub 2021 Jul 30.

Liverpool Head and Neck Centre, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L3 9TA, UK.

The increasing breadth of molecular targets, promise of immune-targeted therapies and repurposed agents have heightened interest in cancer prevention. While, to date, testing of oral cancer chemoprevention strategies has failed to deliver therapeutic agents for routine clinical practice, there remains an urgent need for further clinical research to overcome this hurdle. Patients at the greatest risk of disease stand to benefit the most from inclusion in clinical trials; therefore, there is a need to carefully define this population using validated clinical and molecular markers. Read More

View Article and Full-Text PDF

Precision and Immunoprevention Strategies for Tobacco-Related Head and Neck Cancer Chemoprevention.

Curr Treat Options Oncol 2021 05 15;22(6):52. Epub 2021 May 15.

Department of Medicine, University of Arizona, 1515 N. Campbell Ave, PO Box 245024, Tucson, AZ, 85724-5024, USA.

Opinion Statement: To date, there is no FDA-approved chemoprevention approach for tobacco-related HNSCC. Effective chemoprevention approaches validated in sufficiently powered randomized trials are needed to reduce the incidence and improve survival. In this review, we recap the challenges encountered in past chemoprevention trials and discuss emerging approaches, with major focus on green chemoprevention, precision prevention, and immunoprevention. Read More

View Article and Full-Text PDF

The 4-NQO mouse model: An update on a well-established in vivo model of oral carcinogenesis.

Methods Cell Biol 2021 12;163:197-229. Epub 2020 Nov 12.

Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France; Department of Medical Oncology, Centre Léon Bérard, Lyon, France. Electronic address:

The early detection and management of oral premalignant lesions (OPMDs) improve their outcomes. Animal models that mimic histological and biological processes of human oral carcinogenesis may help to improve the identification of OPMD at-risk of progression into oral squamous cell carcinoma and to develop preventive strategies for the entire field of cancerization. No animal model is perfectly applicable for investigating human oral carcinogenesis. Read More

View Article and Full-Text PDF
November 2021

Polyamines and related signaling pathways in cancer.

Cancer Cell Int 2020 Nov 5;20(1):539. Epub 2020 Nov 5.

Department of Otorhinolaryngology-Head and Neck Surgery, China-Japan Union Hospital, Jilin University, Changchun, Jilin Province, China.

Polyamines are aliphatic compounds with more than two amino groups that play various important roles in human cells. In cancer, polyamine metabolism dysfunction often occurs, and regulatory mechanisms of polyamine. This review summarizes the existing research on the metabolism and transport of polyamines to study the association of oncogenes and related signaling pathways with polyamines in tumor cells. Read More

View Article and Full-Text PDF
November 2020

NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis.

Cancers (Basel) 2020 Dec 2;12(12). Epub 2020 Dec 2.

Jacqui Wood Cancer Centre, Division of Cellular Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK.

NF-E2 p45-related factor 2 (NRF2, encoded in the human by ) mediates short-term adaptation to thiol-reactive stressors. In normal cells, activation of NRF2 by a thiol-reactive stressor helps prevent, for a limited period of time, the initiation of cancer by chemical carcinogens through induction of genes encoding drug-metabolising enzymes. However, in many tumour types, NRF2 is permanently upregulated. Read More

View Article and Full-Text PDF
December 2020

An Overview of Cancer Prevention: Chemoprevention and Immunoprevention.

Authors:
Kyle J Gu Guojun Li

J Cancer Prev 2020 Sep;25(3):127-135

Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Cancer prevention encompasses a broad spectrum of strategies designed to lower the chance of developing cancer and reduce the morbidity of established cancer. There are three levels of cancer prevention. Eliminating or mitigating cancer risk factors by adopting healthy behaviors and lifestyles, such as avoiding tobacco and alcohol use, exercising, eating a healthy diet, and applying sunscreen to protect against UV exposure, belongs to primary prevention and is the easiest and most effective way of preventing cancer for the general public. Read More

View Article and Full-Text PDF
September 2020

An Integrated Approach for Preventing Oral Cavity and Oropharyngeal Cancers: Two Etiologies with Distinct and Shared Mechanisms of Carcinogenesis.

Cancer Prev Res (Phila) 2020 08 20;13(8):649-660. Epub 2020 May 20.

Department of Public Health Sciences, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania.

Head and neck squamous cell carcinoma (HNSCC) was the 7th most common malignancy worldwide in 2018 and despite therapeutic advances, the overall survival rate for oral squamous cell carcinoma (OSCC; ∼50%) has remained unchanged for decades. The most common types are OSCC and oropharyngeal squamous cell carcinoma (OPSCC, survival rate ∼85%). Tobacco smoking is a major risk factor of HNSCC. Read More

View Article and Full-Text PDF

Betel quid-associated cancer: Prevention strategies and targeted treatment.

Cancer Lett 2020 05 26;477:60-69. Epub 2020 Feb 26.

Environment-Omics-Disease Research Center, China Medical University Hospital, China Medical University, Taichung, Taiwan; Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Betel quid (BQ) and areca nut use are at risk of cancer. This review includes the latest evidence of carcinogenesis caused by BQ exposure, suggests possible prevention strategies. We conducted a systematic literature search in the PubMed and Web of Science databases to identify relevant articles published in the past 10 years according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria. Read More

View Article and Full-Text PDF

Chromosome fragility in the buccal epithelium in patients with Fanconi anemia.

Cancer Lett 2020 03 10;472:1-7. Epub 2019 Dec 10.

Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain; Center for Biomedical Network Research on Rare Diseases (CIBERER), Madrid, Spain; Sant Pau Biomedical Research Institute, Sant Pau Hospital, Barcelona, Spain; Department of Genetics, Sant Pau Hospital, Barcelona, Spain. Electronic address:

Fanconi anemia (FA) is a rare genome instability syndrome characterized by progressive bone marrow failure and predisposition to cancer, especially head and neck squamous cell carcinoma. Surgical resection is the standard of care for solid tumors, as patients with FA do not tolerate genotoxic chemotherapies or radiation, leading to poor prognosis. It is therefore imperative to develop chemoprevention strategies such as the identification of novel biomarkers to detect the formation of the tumor before its emergence and to use them in clinical trials aimed to counteract genome instability of patients with FA in tissues at risk. Read More

View Article and Full-Text PDF

Progress in Drug and Formulation Development for the Chemoprevention of Oral Squamous Cell Carcinoma: A Review.

Recent Pat Drug Deliv Formul 2019 ;13(1):16-36

Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh 786004, Assam, India.

Background: Cancer is a life-threatening global problem with high incidence rates. Prioritizing the prevention of cancer, chemopreventive agents have drawn much attention from the researchers.

Objective: This review focuses on the discussion of the progress in the development of chemopreventive agents and formulations related to the prevention of oral cancer. Read More

View Article and Full-Text PDF
January 2020

PARP Inhibitors: Extending Benefit Beyond -Mutant Cancers.

Clin Cancer Res 2019 07 13;25(13):3759-3771. Epub 2019 Feb 13.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

A mounting body of evidence now indicates that PARP inhibitors have the potential to be used as a foundation for both monotherapy and combination strategies across a wide spectrum of molecular backgrounds and tumor types. Although PARP inhibitors as a class display many similarities, critical differences in structure can translate into differences in tolerability and antitumor activity that have important implications for the clinic. Furthermore, while PARP inhibitors have demonstrated a clear role in treating tumors with underlying homologous recombination deficiencies, there is now biological and early clinical evidence to support their use in other molecular subsets of cancer, including tumors associated with high levels of replication stress such as small-cell lung cancer. Read More

View Article and Full-Text PDF

Outcomes for patients with second primary malignancy after primary surgical treatment for early-stage squamous cell carcinoma of the oral cavity.

Head Neck 2018 11 10;40(11):2347-2352. Epub 2018 Oct 10.

University of Zagreb School of Medicine, Department of Maxillofacial Surgery, University Hospital Dubrava, Zagreb, Croatia.

Background: The purpose of our article was to describe a tertiary center's experience with patients with primarily surgically treated early-stage intraoral cancer with a second primary malignancy confirmed during follow-up.

Methods: A total of 183 patients were primarily surgically treated for oral cancer between 2000 and 2004. Among these, 24 patients (13. Read More

View Article and Full-Text PDF
November 2018

Eating Green: Shining Light on the Use of Dietary Phytochemicals as a Modern Approach in the Prevention and Treatment of Head and Neck Cancers.

Curr Top Med Chem 2018 ;18(3):182-191

National Center for Natural Products Research, School of Pharmacy, University of Mississippi, Mississippi, United States.

Enthusiasm for the use of dietary bioactive compounds as chemopreventive agents and adjuvants for current therapies has increased laboratory research conducted on several types of cancers including Head and Neck Squamous Cell Carcinoma (HNSCC). The green chemoprevention movement is a modern approach to highlight healthy lifestyle changes that aim to decrease the incidence of HNSCC. A healthy diet can be an effective way to prevent the development of oral cancers. Read More

View Article and Full-Text PDF

The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competent complex.

Genome Biol 2017 Dec 20;18(1):237. Epub 2017 Dec 20.

Oncogenomic and Epigenetic Unit, Italian National Cancer Institute, "Regina Elena", 00144, Rome, Italy.

Background: Circular RNAs are a class of endogenous RNAs with various functions in eukaryotic cells. Worthy of note, circular RNAs play a critical role in cancer. Currently, nothing is known about their role in head and neck squamous cell carcinoma (HNSCC). Read More

View Article and Full-Text PDF
December 2017

Are plant-based functional foods better choice against cancer than single phytochemicals? A critical review of current breast cancer research.

Biomed Pharmacother 2017 Dec 1;96:1465-1477. Epub 2017 Dec 1.

Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic. Electronic address:

Breast cancer is the most common malignancy in women worldwide. Over 90% of all breast cancer cases are of different 'sporadic' cell types, thus placing emphasis on the need for breast cancer prevention and new effective treatment strategies. In recent years, pre-clinical research provides growing evidence regarding the beneficial action of bioactive plant-derived substances - phytochemicals, on multiple cancer-related biological pathways. Read More

View Article and Full-Text PDF
December 2017

Barrett's oesophagus: Current controversies.

World J Gastroenterol 2017 Jul;23(28):5051-5067

Chidi Amadi, Piers Gatenby, Regional Oesophagogastric Unit, Royal Surrey County Hospital, Guildford GU2 7XX, United Kingdom.

Oesophageal adenocarcinoma is rapidly increasing in Western countries. This tumour frequently presents late in its course with metastatic disease and has a very poor prognosis. Barrett's oesophagus is an acquired condition whereby the native squamous mucosa of the lower oesophagus is replaced by columnar epithelium following prolonged gastro-oesophageal reflux and is the recognised precursor lesion for oesophageal adenocarcinoma. Read More

View Article and Full-Text PDF

Parthenolide attenuates 7,12-dimethylbenz[a]anthracene induced hamster buccal pouch carcinogenesis.

Mol Cell Biochem 2018 Mar 12;440(1-2):11-22. Epub 2017 Aug 12.

Cancer Biology Unit, Department of Biochemistry, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamil Nadu, 625 021, India.

Over the decades, the survival rates for oral cancer have not improved despite development in novel diagnostic and therapeutic strategies. Therefore, the present study is aimed at investigating the chemopreventive potential of parthenolide in DMBA-induced hamster buccal pouch carcinogenesis. The hamsters were divided into 4 groups (n = 6/group). Read More

View Article and Full-Text PDF

Antibiotic Prophylaxis in Clean-Contaminated Head and Neck Surgery: A Systematic Review and Meta-analysis.

Otolaryngol Head Neck Surg 2017 10 11;157(4):580-588. Epub 2017 Jul 11.

1 Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.

Objective To determine the optimal duration and type of antibiotic prophylaxis in patients undergoing clean-contaminated resection for head and neck cancer. Data Sources Search strategies were created by a medical librarian, implemented in multiple databases, and completed in June 2016. Review Methods The population of interest was adults ≥18 years undergoing clean-contaminated head and neck surgery, intervention was postoperative antibiotic prophylaxis, comparator was duration and types of antibiotics used, outcome was the wound infection rate, and the study design was randomized controlled trials (RCTs). Read More

View Article and Full-Text PDF
October 2017

ALDH2 polymorphism and alcohol-related cancers in Asians: a public health perspective.

J Biomed Sci 2017 Mar 3;24(1):19. Epub 2017 Mar 3.

Department of Chemical and Systems Biology, Stanford University, School of Medicine, 269 Campus Drive, CCSR Building, Rm. 3140, Stanford, CA, 94305, USA.

The occurrence of more than 200 diseases, including cancer, can be attributed to alcohol drinking. The global cancer deaths attributed to alcohol-consumption rose from 243,000 in 1990 to 337,400 in 2010. In 2010, cancer deaths due to alcohol consumption accounted for 4. Read More

View Article and Full-Text PDF

Oral Squamous Cell Carcinoma: Current Treatment Strategies and Nanotechnology-Based Approaches for Prevention and Therapy.

Crit Rev Ther Drug Carrier Syst 2016 ;33(4):363-400

Department of Pharmaceutics, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, India.

Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer; it involves damage to oral epithelial cells due to accumulation of multiple genetic mutations in the cells. OSCC remains major cause of morbidity and mortality in patients with head and neck cancers. Tobacco, smoking, alcohol consumption alone or with chewing tobacco, and betel quid are potential carcinogens contributing to the high occurrence of OSCC. Read More

View Article and Full-Text PDF
February 2017

Oxidative stress from reflux esophagitis to esophageal cancer: the alleviation with antioxidants.

Free Radic Res 2016 Oct 19;50(10):1071-1079. Epub 2016 May 19.

a Digestive Disease Center , CHA University Bundang Medical Center , Seongnam , Korea.

The incidence of reflux esophagitis increases in world, affecting approximately 20% of Western populations and its consequent lesion, Barrett's esophagus (BE), established as the primary precursor lesion of esophageal adenocarcinoma (EAC) or Barrett associated adenocarcinoma (BAA), is also increasing in incidence in Asian countries as well as Western countries. The fact that surveillance strategies have not had a major benefit in decreasing the incidence of EAC increased attention to arrest or delay the progression of BE to EAC. Since sustained inflammation and consequent oxidative stress plays core pathogenic role in reflux esophagitis, BE, and BAA, attention paid to anti-inflammatory and antioxidative agents in the treatment of reflux esophagitis. Read More

View Article and Full-Text PDF
October 2016

Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates.

Nat Commun 2016 08 30;7:12601. Epub 2016 Aug 30.

Department of Bioinformatics &Computational Biology, University of Texas MD Anderson Cancer Center Houston, Houston, Texas 77030, USA.

Cutaneous squamous cell carcinoma (cuSCC) comprises 15-20% of all skin cancers, accounting for over 700,000 cases in USA annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). To identify potential targets for molecularly targeted chemoprevention, here we perform integrated cross-species genomic analysis of cuSCC development through the preneoplastic AK stage using matched human samples and a solar ultraviolet radiation-driven Hairless mouse model. Read More

View Article and Full-Text PDF

Prognostic factors, predictive markers and cancer biology: the triad for successful oral cancer chemoprevention.

Future Oncol 2016 Oct 22;12(20):2379-86. Epub 2016 Jun 22.

Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 432, Houston, TX 77030, USA.

Oral squamous cell carcinomas represent a significant cancer burden worldwide. Unfortunately, chemoprevention strategies investigated to date have failed to produce an agent considered standard of care to prevent oral cancers. Nonetheless, recent advances in clinical trial design may streamline drug development in this setting. Read More

View Article and Full-Text PDF
October 2016

Familial adenomatous polyposis in pediatrics: natural history, emerging surveillance and management protocols, chemopreventive strategies, and areas of ongoing debate.

Fam Cancer 2016 07;15(3):477-85

Department of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Mercy Hospital and Clinics, Kansas City, MO, USA.

Familial adenomatous polyposis (FAP) is a hereditary condition with a near 100 % lifetime risk of colorectal cancer without prophylactic colectomy. Most patients with FAP have a mutation in the adenomatous polyposis coli gene on chromosome 5q22. This condition frequently presents in children with polyps developing most frequently in the second decade of life and surveillance colonoscopy is required starting at age ten. Read More

View Article and Full-Text PDF

Mechanisms of esophageal adenocarcinoma formation and approaches to chemopreventive intervention.

Semin Oncol 2016 Feb 15;43(1):78-85. Epub 2015 Dec 15.

Division of Cancer Prevention, National Cancer Institute, Rockville, MD, USA.

The incidence of esophageal adenocarcinoma (EAC), a debilitating and highly lethal malignancy, has risen dramatically over the past 40 years in the United States and other Western countries. To reverse this trend, EAC prevention and early detection efforts by clinicians, academic researchers and endoscope manufacturers have targeted Barrett's esophagus (BE), the widely accepted EAC precursor lesion. Data from surgical, endoscopic and pre-clinical investigations strongly support the malignant potential of BE. Read More

View Article and Full-Text PDF
February 2016

Overview of gastrointestinal cancer prevention in Asia.

Best Pract Res Clin Gastroenterol 2015 Dec 11;29(6):855-67. Epub 2015 Sep 11.

CHA Cancer Prevention Research Center, CHA University, CHA Bio Complex, Seongnam, Republic of Korea; Digestive Disease Center, CHA University Bundang Medical Center, Seongnam, Republic of Korea. Electronic address:

"War on cancer" was declared through the National Cancer Act by President Richard Nixon in 1971, but cancer statistics from the American Cancer Society and other sources indicated the failure of this war, suggesting instead focus on the message that a "prevention strategy" might be much more effective than cancer treatment. While cancer statistics notoriously showed sharp increases in incidence as well as in mortality concurrent with economic growth in Asia, fortunately Asian countries benefit from plentiful resources of natural compounds, which can prevent cancer. Just like cancer chemotherapeutics targeted to kill cancer cells in Western countries, natural agents activating molecular mechanisms for cancer prevention, reversion of premalignant tumors, and even ablation of cancer stem cells, are very abundant in Asia. Read More

View Article and Full-Text PDF
December 2015