109 results match your criteria Chemistry-an Asian Journal[Journal]


Modeling plasmas in analytical chemistry-an example of cross-fertilization.

Authors:
Annemie Bogaerts

Anal Bioanal Chem 2020 Mar 31. Epub 2020 Mar 31.

Research group PLASMANT, Department of Chemistry, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Antwerp, Belgium.

This paper gives an overview of the modeling work developed in our group in the last 25 years for various plasmas used in analytical spectrochemistry, i.e., glow discharges (GDs), inductively coupled plasmas (ICPs), and laser ablation (LA) for sample introduction in the ICP and for laser-induced breakdown spectroscopy (LIBS). Read More

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http://dx.doi.org/10.1007/s00216-020-02587-8DOI Listing

GABA receptor subtype modulators in medicinal chemistry: an updated patent review (2014-present).

Expert Opin Ther Pat 2020 Jun 20;30(6):409-432. Epub 2020 Apr 20.

NEUROFARBA, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino, Italy.

: Ligands at the benzodiazepine binding site of the GABA receptor (GABAR) act by modulating the effect of GABA (γ-aminobutyric acid). The benzodiazepine drugs are conventionally categorized as positive allosteric modulators enhancing the chloride ion current GABA-induced. In literature there are also reported ligands that act as negative allosteric modulators, reducing chloride ion current, and silent allosteric modulators not influencing the chloride ion flux. Read More

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http://dx.doi.org/10.1080/13543776.2020.1746764DOI Listing

Morpholine As a Scaffold in Medicinal Chemistry: An Update on Synthetic Strategies.

ChemMedChem 2020 Mar 12;15(5):392-403. Epub 2020 Feb 12.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, 15771, Athens, Greece.

Morpholine is a frequently used heterocycle in medicinal chemistry and a privileged structural component of bioactive molecules. This is mainly due to its contribution to a plethora of biological activities as well as to an improved pharmacokinetic profile of such bioactive molecules. The synthesis of morpholines is a subject of much study due to their biological and pharmacological importance, with the last such review being published in 2013. Read More

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http://dx.doi.org/10.1002/cmdc.201900682DOI Listing

Dear Editor, How have you been?

Chem Asian J 2020 Jan;15(1):3-7

Chemistry - An Asian Journal, Weinheim (Germany).

Moving forward: Editor-in-Chief Theresa Kueckmann reflects on the achievements of the past year and offers a glimpse of the future at Chemistry-An Asian Journal. Read More

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http://dx.doi.org/10.1002/asia.201901685DOI Listing
January 2020

Chemistry-An Editorial Journey.

Authors:
Neville Compton

Chemistry 2020 Jan;26(1):11-13

Angewandte Chemie.

The silver anniversary of Chemistry-A European Journal is a great reason to celebrate and a good opportunity for reflection. This Editorial looks back at the history of the journal through the eyes of the Editorials written by a variety of the key players and stakeholders. Read More

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http://dx.doi.org/10.1002/chem.201905102DOI Listing
January 2020

Foreword: CRSI Special Issue.

Authors:
C N R Rao

Chem Asian J 2019 Dec 4;14(24):4432. Epub 2019 Dec 4.

CSIR Centre for Excellence in Chemistry, New Chemistry Unit and International Centre for Materials Science, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur P.O., Bangalore, 560 064, India.

Founding member of the CRSI, C. N. R. Read More

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http://dx.doi.org/10.1002/asia.201901611DOI Listing
December 2019

Interactions among Peers and International Organizations in the 2019 Asian Chemical Congress Held in Taipei.

Chem Asian J 2019 Nov;14(22):3954-3955

Chemistry-An Asian Journal, Wiley-VCH, Boschstr. 12, Weinheim, 69469, Germany.

In their editorial, Reuben Jih-Ru Hwu and Theresa Kueckmann reflect on the objective of the 18 Asian Chemical Congress (ACC). The ACC is a biennial event organized by members of the Federation of Asian Chemical Societies (FACS), an official supporting organization for the publication of the three ACES journals Chemistry-An Asian Journal, Asian Journal of Organic Chemistry, and ChemNanoMat. This special issue showcases the high quality of the 2019 ACC, featuring contributions by Keynote and Invited Speakers. Read More

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http://dx.doi.org/10.1002/asia.201901417DOI Listing
November 2019

Machine Learning in Computational Chemistry: An Evaluation of Method Performance for Nudged Elastic Band Calculations.

J Chem Theory Comput 2019 Nov 9;15(11):6513-6523. Epub 2019 Oct 9.

Graz University of Technology , Institute of Experimental Physics , Petersgasse 16 , 8010 Graz , Austria.

The localization of transition states and the calculation of reaction pathways are routine tasks of computational chemists but often very CPU-intense problems, in particular for large systems. The standard algorithm for this purpose is the nudged elastic band method, but it has become obvious that an "intelligent" selection of points to be evaluated on the potential energy surface can improve its convergence significantly. This article summarizes, compares, and extends known strategies that have been heavily inspired by the machine learning developments of recent years. Read More

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http://dx.doi.org/10.1021/acs.jctc.9b00708DOI Listing
November 2019

Physical insights into mechanistic processes in organometallic chemistry: an introduction.

Authors:
Robert H Morris

Faraday Discuss 2019 Dec;220(0):10-27

Department of Chemistry, University of Toronto, 80 Saint George St., Toronto, Ont. M5S3H6, Canada.

The challenges of research into the mechanisms of 4d versus 3d late transition metal homogeneous catalysts is considered here, particularly catalysts containing hydrides. Included are case studies of C-H bond activation as studied in a collaboration of the Weller and McIndoe groups where a ruthenium (4d) hydride intermediate is detected using ESI-MS analysis of the catalytic mixture, and as studied in a collaboration of the Thomas and Neidig groups where a hydride transfer step involving low valent iron (3d) catalytic species is investigated using low temperature methods including Mössbauer spectroscopy. In the asymmetric hydrogenation of olefins, mechanisms are considered for rhodium (4d) vs. Read More

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http://dx.doi.org/10.1039/c9fd00083fDOI Listing
December 2019

EACH (Excellence in Analytical Chemistry), an Erasmus Mundus Joint Programme: progress and success.

Anal Bioanal Chem 2019 Sep;411(23):5913-5921

Analytical Chemistry, Department of Chemistry - BMC, Uppsala University, Box 599, 75124, Uppsala, Sweden.

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http://dx.doi.org/10.1007/s00216-019-01988-8DOI Listing
September 2019
3 Reads

Silica nanoparticle surface chemistry: An important trait affecting cellular biocompatibility in two and three dimensional culture systems.

Colloids Surf B Biointerfaces 2019 Oct 8;182:110353. Epub 2019 Jul 8.

Department of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology, PO Box: 14965/161, Tehran, Iran. Electronic address:

Great advantages bestowed by mesoporous silica nanoparticles (MSNs) including high surface area, tailorable pore diameter and surface chemistry, and large pore volume render them as efficient tools in biomedical applications. Herein, MSNs with different surface chemistries were synthesized and investigated in terms of biocompatibility and their impact on the morphology of bone marrow-derived mesenchymal stem cells both in 2D and 3D culture systems. Bare MSNs (BMSNs) were synthesized by template removing method using tetraethylorthosilicate (TEOS) as a precursor. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.110353DOI Listing
October 2019
1 Read
4.152 Impact Factor

Role of sulphur-heterocycles in medicinal chemistry: An update.

Eur J Med Chem 2019 Oct 15;180:486-508. Epub 2019 Jul 15.

Department of Chemistry, Maharishi Markandeshwar (Deemed to Be University), Mullana, 133207, Haryana, India. Electronic address:

From many decades, S-heterocycles have maintained their status as an important part and core of FDA approved drugs and medicinally active compounds. With exhaustive exploration of nitrogen heterocycles in medicinal chemistry, researchers have shifted their interest towards other heterocycles, especially, S-heterocycles. Thus several attempts have been made to synthesize a variety of new sulphur containing compounds with high medicinal value and low toxicity profile, in comparison to previous N-heterocycles. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.07.043DOI Listing
October 2019
1 Read

Porpholactone Chemistry: An Emerging Approach to Bioinspired Photosensitizers with Tunable Near-Infrared Photophysical Properties.

Acc Chem Res 2019 09 12;52(9):2620-2633. Epub 2019 Jul 12.

Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering , Peking University , Beijing 100871 , P. R. China.

Chlorophylls, known as the key building blocks of natural light-harvesting antennae, are essential to utilize solar energy from visible to near-infrared (NIR) region during the photosynthesis process. The fundamental studies for the relationship between structure and photophysical properties of chlorophylls disclosed the importance of -peripheral modification and thus boosted the fast growth of NIR absorbing/emissive porphyrinoids via altering the extent of π-conjugation and the degree of distortion from the planarity of macrocycle. Despite the tremendous progress made in various porphyrin-based synthetic models, it still remains a challenge to precisely modulate photophysical properties through fine-tuning of -peripheral structures in the way natural chlorophylls do. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00119DOI Listing
September 2019

Celebrating New Zealand Chemistry.

Authors:
Sally Brooker

Chem Asian J 2019 Apr 25;14(8):1087. Epub 2019 Mar 25.

Department of Chemistry and MacDiarmid Institute for Advanced Materials and Nanotechnology, University of Otago, P.O. Box 56, Dunedin, 9054, New Zealand.

Kia ora! This special issue of Chemistry - An Asian Journal celebrates the breadth and depth of chemistry research being carried out across the eight Universities in New Zealand as well as by some of their alumni. It also coincides with the 150 anniversary of the founding of New Zealand's first university, the University of Otago. Read More

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http://dx.doi.org/10.1002/asia.201900299DOI Listing

Biotin interference in immunoassays based on biotin-strept(avidin) chemistry: An emerging threat.

Biotechnol Adv 2019 Sep - Oct;37(5):634-641. Epub 2019 Mar 11.

University College Cork, Irish Separation Science Cluster ISSC Ireland, Innovative Chromatography Group, Western Rd, Cork T12 YN60, Ireland; University College Cork, School of Chemistry, College Road, Cork T12 YN60, Ireland.

Biotinylated antibodies/antigens are currently used in many immunoassay formats in clinical settings for diversified analytes and biomarkers to offer high detection selectivity and sensitivity. Biotin cannot be synthesized by mammals and must be taken as an essential supplement. Normal intake of biotin from various foods and milk causes no effect on the streptavidin/biotin-based immunoassays. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.03.007DOI Listing
February 2020
16 Reads

Polyatomic Iodine Species at the Air-Water Interface and Its Relevance to Atmospheric Iodine Chemistry: An HD-VSFG and Raman-MCR Study.

J Phys Chem A 2019 Apr 12;123(13):2924-2934. Epub 2019 Mar 12.

Radiation & Photochemistry Division , Bhabha Atomic Research Centre, Homi Bhabha National Institute , Trombay, Mumbai 400085 , India.

Iodine plays a key role in tropospheric ozone destruction, atmospheric new particle formation, as well as growth. Air-water interface happens to be an important reaction site pertaining to such phenomena. However, except iodide (I), the behavior of other iodine species, for example, triiodide (I) and iodate (IO, the most abundant iodine species in seawater) at the aqueous interface and their effect on the interfacial water are largely unknown. Read More

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http://dx.doi.org/10.1021/acs.jpca.9b00828DOI Listing

Back to the Roots … and the Future!

Chem Asian J 2019 Jan 13;14(1):3-5. Epub 2018 Dec 13.

Chemistry - An Asian Journal, Weinheim, Germany.

Taking stock: Editor-in-Chief Theresa Kueckmann reflects on the roots of Chemistry - An Asian Journal and lays out how these connect to the plans ahead. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/asia.2018018
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http://dx.doi.org/10.1002/asia.201801817DOI Listing
January 2019
14 Reads

Temporal metabolic partitioning of the yeast and protist cellular networks: the cell is a global scale-invariant (fractal or self-similar) multioscillator.

J Biomed Opt 2018 12;24(5):1-17

University of Sheffield, Department of Molecular Biology and Biotechnology, Firth Court, Western Ban, United Kingdom.

Britton Chance, electronics expert when a teenager, became an enthusiastic student of biological oscillations, passing on this enthusiasm to many students and colleagues, including one of us (DL). This historical essay traces BC's influence through the accumulated work of DL to DL's many collaborators. The overall temporal organization of mass-energy, information, and signaling networks in yeast in self-synchronized continuous cultures represents, until now, the most characterized example of in vivo elucidation of time structure. Read More

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http://dx.doi.org/10.1117/1.JBO.24.5.051404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992908PMC
December 2018
3 Reads

Immunohisto(cyto)chemistry: an old time classic tool driving modern oncological therapies.

Histol Histopathol 2019 Apr 27;34(4):335-352. Epub 2018 Nov 27.

Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

In the era of precision medicine immunohistochemistry (IHC) and immunocytochemistry (ICC) share some of the highlights in personalized treatment. Survival data obtained from clinical trials shape the cut-offs and IHC scoring that serve as recommendations for patient selection both for targeted and conventional therapies. Assessment of Estrogen and Progesterone Receptors along with HER2 status has been among the first approved immunostaining assays revolutionizing breast cancer treatment. Read More

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http://www.hh.um.es/Abstracts/Vol_/_/__18069.htm
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http://dx.doi.org/10.14670/HH-18-069DOI Listing
April 2019
115 Reads
2.096 Impact Factor

Beyond the Roles in Biomimetic Chemistry: An Insight into the Intrinsic Catalytic Activity of an Enzyme for Tumor-Selective Phototheranostics.

ACS Nano 2018 12 16;12(12):12169-12180. Epub 2018 Nov 16.

Institute of Photomedicine, Shanghai Skin Disease Hospital, The Institute for Biomedical Engineering and Nano Science , Tongji University School of Medicine , Shanghai 200443 , China.

Protein-assisted biomimetic synthesis has been an emerging offshoot of nanofabrication in recent years owing to its features of green chemistry, facile process, and ease of multi-integration. As a result, many proteins have been used for biomimetic synthesis of varying kinds of nanostructures. Although the efforts on exploring new proteins and investigating their roles in biomimetic chemistry are increasing, the most essential intrinsic properties of proteins are largely neglected. Read More

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http://pubs.acs.org/doi/10.1021/acsnano.8b05797
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http://dx.doi.org/10.1021/acsnano.8b05797DOI Listing
December 2018
16 Reads

Cuticular hydrocarbon chemistry, an important factor shaping the current distribution pattern of the imported fire ants in the USA.

J Insect Physiol 2018 10 18;110:34-43. Epub 2018 Aug 18.

State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, PR China. Electronic address:

Two sibling species, Solenopsis richteri and S. invicta, were both introduced into the southern USA from South America in the early 20th century. Today, S. Read More

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http://dx.doi.org/10.1016/j.jinsphys.2018.08.006DOI Listing
October 2018
23 Reads

The anticonvulsant and anti-plasmid conjugation potential of Thymus vulgaris chemistry: An in vivo murine and in vitro study.

Food Chem Toxicol 2018 Oct 25;120:472-478. Epub 2018 Jul 25.

Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8b, PL 20-090, Lublin, Poland; Isobolographic Analysis Laboratory, Institute of Rural Health, Jaczewskiego 2, PL 20-950, Lublin, Poland.

The high-performance counter-current chromatography was used for the efficient purification of single constituents from Thymus vulgaris essential oil. Mixtures of n-heptane, ethyl acetate, methanol, and water (5:2:5:2 and 4:1:4:1 v/v), allowed purification of eugenol, 1-octen-3- ol, borneol, thymol, terpinen-4-ol, and camphor, while n-hexane, acetonitrile, and tert-butyl methyl ether (1:1:0.1 v/v) yielded carvacrol, borneol, linalyl acetate, caryophyllene oxide, p-cymene, and eucalyptol. Read More

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http://dx.doi.org/10.1016/j.fct.2018.07.045DOI Listing
October 2018
15 Reads

Platinum in Chemistry: An Adventure from Phosphorescent Materials to Catalytic C-H Functionalization.

Authors:
Shouquan Huo

Chem Rec 2018 Nov 4;18(11):1583-1595. Epub 2018 Jun 4.

Department of Chemistry, East Carolina University, Greenville, North Carolina, 27858, USA.

Platinum is a precious and versatile metal and has played important roles in various fields of chemistry ranging from functional materials to anticancer drugs and catalysis. This account highlights an adventurous journey of platinum from promoting phosphorescence to catalyzing a C-H functionalization reaction, or you may consider it our research adventure from phosphorescent materials to catalysis. Interestingly, this journey is driven by a series of "bad" reactions, and of course more importantly by our curiosity about the "bad" reactions. Read More

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http://dx.doi.org/10.1002/tcr.201800019DOI Listing
November 2018
2 Reads

Machine Learning for Organic Synthesis: Are Robots Replacing Chemists?

Angew Chem Int Ed Engl 2018 06 27;57(24):6978-6980. Epub 2018 Apr 27.

Institute of Organic Chemistry, University of Vienna, Währinger Str. 38, 1090, Vienna, Austria.

Machines learn chemistry: An artificial intelligence algorithm has learned to predict the outcomes of C-N coupling reactions from a few thousand nanomole-scale experiments. This Highlight discusses this work in the context of other state-of-the-art approaches for predicting the yields of organic reactions and explains the significance of the results. Read More

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http://dx.doi.org/10.1002/anie.201803562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033144PMC
June 2018
1 Read

Chiral Drug Analysis in Forensic Chemistry: An Overview.

Molecules 2018 Jan 28;23(2). Epub 2018 Jan 28.

Institute of Research and Advanced Training in Health Sciences and Technologies , Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal.

Many substances of forensic interest are chiral and available either as racemates or pure enantiomers. Application of chiral analysis in biological samples can be useful for the determination of legal or illicit drugs consumption or interpretation of unexpected toxicological effects. Chiral substances can also be found in environmental samples and revealed to be useful for determination of community drug usage (sewage epidemiology), identification of illicit drug manufacturing locations, illegal discharge of sewage and in environmental risk assessment. Read More

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http://dx.doi.org/10.3390/molecules23020262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017579PMC
January 2018
5 Reads

What History Tells Us about the Distinct Nature of Chemistry.

Authors:
Hasok Chang

Ambix 2017 Nov 8;64(4):360-374. Epub 2018 Jan 8.

a University of Cambridge , UK.

Attention to the history of chemistry can help us recognise the characteristics of chemistry that have helped to maintain it as a separate scientific discipline with a unique identity. Three such features are highlighted in this paper. First, chemistry has maintained a distinct type of theoretical thinking, independent from that of physics even in the era of quantum chemistry. Read More

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http://dx.doi.org/10.1080/00026980.2017.1412135DOI Listing
November 2017
2 Reads

Looking Back, Looking Forward.

Chem Asian J 2018 Jan 15;13(1):3-4. Epub 2017 Dec 15.

Chemistry - An Asian Journal, Weinheim, Germany.

Taking stock: Editor-in-Chief Theresa Kueckmann reflects on the year 2017 and lays out plans for the new year. Read More

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http://doi.wiley.com/10.1002/asia.201701698
Publisher Site
http://dx.doi.org/10.1002/asia.201701698DOI Listing
January 2018
18 Reads

Continuous Scientific Growth through an Open-Minded Attitude.

Authors:
Susumu Kitagawa

Chem Asian J 2018 Jan 15;13(1):7-8. Epub 2017 Dec 15.

Kyoto University, Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Yoshida, Sakyo-ku, Kyoto, 606-8501, Japan.

"New frontiers in chemistry must be built on a solid foundation because innovation is rooted in a firm understanding of traditional fields. However, researchers must ambitiously navigate unchartered areas. An open-minded attitude to learn traditional research fields will lead to new developments in these fields. Read More

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http://dx.doi.org/10.1002/asia.201701683DOI Listing
January 2018
3 Reads

Australian Century.

Chem Asian J 2017 Jul 19;12(13):1411-1412. Epub 2017 Jun 19.

CEO, Royal Australian Chemical Institute.

Let the corks pop! This year, the Royal Australian Chemical Institute (RACI), a partner of the Asian Chemical Editorial Society (ACES) and co-owner of Chemistry - An Asian Journal, celebrates its 100th anniversary. This special issue honors that occasion. In the Editorial, Chemistry - An Asian Journal Editor Theresa Kueckmann and RACI CEO Roger Stapleford look at the connection between the journal, ACES and RACI and how RACI has become a driving force in connecting chemists among themselves and within Australian society. Read More

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http://dx.doi.org/10.1002/asia.201700809DOI Listing
July 2017
2 Reads

From Content to Collaboration.

Chem Asian J 2017 Jan 27;12(1):3-5. Epub 2016 Dec 27.

Editor, Chemistry - An Asian Journal.

Looking back, looking forward: Editor Theresa Kueckmann looks back to the journal's highlights of 2016 and forward to exciting new developments in 2017. Read More

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http://dx.doi.org/10.1002/asia.201601657DOI Listing
January 2017
1 Read

The Use of the Comins-Meyers Amide in Synthetic Chemistry: an Overview.

Nat Prod Commun 2016 Nov;11(11):1729-1732

Formylation reactions are fundamental operations in synthetic chemistry allowing the incorporation into a given structure formyl groups amenable to further deiivatization. Conceptually, the introduction of such groups through the reaction between an electrophilic donor and a nucleophilic acceptor (i.e. Read More

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November 2016
1 Read

Cu-Click Compatible Triazabutadienes To Expand the Scope of Aryl Diazonium Ion Chemistry.

Org Lett 2016 10 13;18(19):4948-4950. Epub 2016 Sep 13.

Department of Chemistry and Biochemistry, University of Arizona , 1306 East University Boulevard, Tucson, Arizona 85721, United States.

Triazabutadienes can be used to readily generate reactive aryl diazonium ions under mild, physiologically relevant conditions. These conditions are compatible with a range of functionalities that do not tolerate traditional aryl diazonium ion generation. To increase the utility of this aryl diazonium ion releasing chemistry an alkyne-containing triazabutadiene was synthesized. Read More

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http://dx.doi.org/10.1021/acs.orglett.6b02420DOI Listing
October 2016
6 Reads

Correlating Calmodulin Landscapes with Chemical Catalysis in Neuronal Nitric Oxide Synthase using Time-Resolved FRET and a 5-Deazaflavin Thermodynamic Trap.

ACS Catal 2016 Aug 28;6(8):5170-5180. Epub 2016 Jun 28.

Manchester Synthetic Biology Research Centre for Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, The University of Manchester , Manchester M1 7DN, United Kingdom.

A major challenge in enzymology is the need to correlate the dynamic properties of enzymes with, and understand the impact on, their catalytic cycles. This is especially the case with large, multicenter enzymes such as the nitric oxide synthases (NOSs), where the importance of dynamics has been inferred from a variety of structural, single-molecule, and ensemble spectroscopic approaches but where motions have not been correlated experimentally with mechanistic steps in the reaction cycle. Here we take such an approach. Read More

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http://dx.doi.org/10.1021/acscatal.6b01280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993522PMC
August 2016
32 Reads

From steroids to aqueous supramolecular chemistry: an autobiographical career review.

Authors:
Bruce C Gibb

Beilstein J Org Chem 2016 12;12:684-701. Epub 2016 Apr 12.

Department of Chemistry, Tulane University, New Orleans, LA 70118, USA.

The focus of my group's research is aqueous supramolecular chemistry; we try to understand how chemical entities interact with water and consequently how they interact with each other. This personal history recounts my career experiences that led to his involvement with this fascinating area of science. Read More

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http://dx.doi.org/10.3762/bjoc.12.69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902062PMC
June 2016
1 Read

Quinazolines and quinazolinones as ubiquitous structural fragments in medicinal chemistry: An update on the development of synthetic methods and pharmacological diversification.

Bioorg Med Chem 2016 06 18;24(11):2361-81. Epub 2016 Mar 18.

Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan. Electronic address:

Nitrogen-rich heterocycles, particularly quinazolines and quinazolinones, represent a unique class of diversified frameworks displaying a broad spectrum of biological functions. Over the past several years, intensive medicinal chemistry efforts have generated numerous structurally functionalized quinazoline and quinazolinone derivatives. Interest in expanding the biological effects, demonstrated by these motifs, is growing exponentially, as indicated by the large number of publications reporting the easy accessibility of these skeletons in addition to the diverse nature of synthetic as well as biological applications. Read More

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http://dx.doi.org/10.1016/j.bmc.2016.03.031DOI Listing
June 2016
14 Reads

Molecular Asymmetry in Prebiotic Chemistry: An Account from Meteorites.

Life (Basel) 2016 Apr 13;6(2). Epub 2016 Apr 13.

School of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA.

Carbonaceous Chondrite (CC) meteorites are fragments of asteroids, solar planetesimals that never became large enough to separate matter by their density, like terrestrial planets. CC contains various amounts of organic carbon and carry a record of chemical evolution as it came to be in the Solar System, at the time the Earth was formed and before the origins of life. We review this record as it pertains to the chiral asymmetry determined for several organic compounds in CC, which reaches a broad molecular distribution and enantiomeric excesses of up to 50%-60%. Read More

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http://dx.doi.org/10.3390/life6020018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931455PMC
April 2016
1 Read

The dual-role of Pt(iv) complexes as active drug and crosslinker for micelles based on β-cyclodextrin grafted polymer.

J Mater Chem B 2016 Mar 29;4(12):2114-2123. Epub 2016 Feb 29.

Centre for Advanced Macromolecular Design, School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.

With a combination of RAFT and click chemistry an amphiphilic block copolymer with poly(ethylene glycol) methyl ether methacrylate (POEGMEMA) as hydrophilic block and poly(propargyl methacrylate) (PMA) as hydrophobic block has been successfully synthesized. To this, 6-azide-6-deoxy-β-cyclodextrin (N3-β-CD) was clicked creating a hosting environment for a hydrophobic small molecule platinum pro-drug. Oxoplatin, the oxidized version of cisplatin, has been modified on its axial ligand introducing cholic acid groups through esterification. Read More

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http://dx.doi.org/10.1039/c5tb02429cDOI Listing

Total Syntheses of Aporphine Alkaloids via Benzyne Chemistry: An Approach to the Formation of Aporphine Cores.

J Org Chem 2015 Oct 28;80(20):10033-40. Epub 2015 Sep 28.

Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo , Diadema, SP, Brazil.

Total syntheses of lysicamine, (±)-nuciferine, (±)-nornuciferine, (±)-zanthoxyphylline iodide, (±)-O-methylisothebaine, and (±)-trimethoxynoraporphine were accomplished by an approach that involves the formation of aporphine cores through reactions between an isoquinoline derivative and silylaryl triflates promoted by CsF. Unprecedented formations of aporphine cores proceeded in good yields presumably through [4 + 2] cycloaddition reactions followed by hydrogen migrations. Read More

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http://dx.doi.org/10.1021/acs.joc.5b01634DOI Listing
October 2015
3 Reads

Synthesis of 1,2,3-triazol-1-yl-methaneboronic acids via click chemistry: an easy access to a new potential scaffold for protease inhibitors.

European J Org Chem 2015 Feb;2015(5):1075-1083

Dipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio-Emilia, Via Campi 183, 41125 Modena (MO).

Stereoselective synthesis of previously unreported 1,2,3-triazol-1-yl-methaneboronic acids has been achieved from azidomethaneboronates by Copper-catalyzed Azide-Alkyne Cycloaddition (CuAAC). The proximity of the cycloaddition reaction center to the boronic group is not detrimental for the stability of the -carbon-boron bond nor to the stereoisomeric composition, further expanding the field of application of click chemistry to new boronate substrates and offering a new potential scaffold for protease inhibitors. Read More

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http://dx.doi.org/10.1002/ejoc.201403408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527660PMC
February 2015
2 Reads

Friendship chemistry: An examination of underlying factors.

Soc Sci J 2015 Jun;52(2):239-247

California State University, San Bernardino.

Interpersonal chemistry refers to a connection between two individuals that exists upon first meeting. The goal of the current study is to identify beliefs about the underlying components of friendship chemistry. Individuals respond to an online Friendship Chemistry Questionnaire containing items that are derived from interdependence theory and the friendship formation literature. Read More

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http://dx.doi.org/10.1016/j.soscij.2015.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470381PMC
June 2015
12 Reads

Glycans in Medicinal Chemistry: An Underexploited Resource.

ChemMedChem 2015 Aug 14;10(8):1291-5. Epub 2015 May 14.

CIC bioGUNE: Center for Cooperative Research in Biosciences, Bizkaia Technology Park, 48160 Derio (Spain).

The biological relevance of glycans as mediators of key physiological processes, including disease-related mechanisms, makes them attractive targets for a wide range of medical applications. Despite their important biological roles, especially as molecular recognition elements, carbohydrates have not been fully exploited as therapeutics mainly due to the scarcity of structure-activity correlations and their non-drug-like properties. A more detailed understanding of the complex carbohydrate structures and their associated functions should contribute to the development of new glycan-based pharmaceuticals. Read More

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http://dx.doi.org/10.1002/cmdc.201500107DOI Listing
August 2015
4 Reads

A reason to celebrate!

Chem Asian J 2015 Jan;10(1):4-5

Editor, Chemistry - An Asian Journal.

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http://dx.doi.org/10.1002/asia.201403344DOI Listing
January 2015
1 Read

Low-valent chemistry: an alternative approach to phosphorus-containing oligomers.

Inorg Chem 2014 Dec 1;53(24):13061-9. Epub 2014 Dec 1.

Department of Chemistry and Biochemistry, University of Windsor , Windsor, Ontario N9B 3P4, Canada.

A convenient preparative approach to low-valent phosphorus-rich oligomers is presented. Ligand substitution reactions involving anionic diphosphine ligands of the form [(PR2)2N](-) and [(PPh2)2C5H3](-) and a triphosphenium bromide P(I) precursor result in the formation of phosphorus(I)-containing heterocycles, several of which are of types that have never been prepared before. The methodology described also allows for the preparation of the known heterocycle cyclo-[P(PPh2)N(PPh2)]2 in better yields and purity than the synthetic approach reported previously. Read More

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http://dx.doi.org/10.1021/ic502229wDOI Listing
December 2014
6 Reads

Palladium/norbornene chemistry: an unexpected route to methanocarbazole derivatives via three Csp3-Csp2/Csp3-N/Csp2-N bond formations in a single synthetic sequence.

Chem Commun (Camb) 2015 Jan;51(1):225-8

School of Chemistry, College of Science, University of Tehran, P.O. Box 14155-6455, Tehran, Iran.

A Catellani reaction terminated by palladacycle amination leading to methanocarbazoles is reported. The outcome is the formation of three different Csp(3)-Csp(2)/Csp(3)-N/Csp(2)-N bonds through a Heck reaction/C-H activation/double amination cascade in one process. Read More

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http://dx.doi.org/10.1039/c4cc06789dDOI Listing
January 2015
4 Reads

International collaboration at its finest.

Chem Asian J 2014 Aug 24;9(8):1972-3. Epub 2014 Jun 24.

Editor, Chemistry-An Asian Journal.

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http://dx.doi.org/10.1002/asia.201402551DOI Listing

Combining phytoextraction and ecocatalysis: a novel concept for greener chemistry, an opportunity for remediation.

Authors:
Claude Grison

Environ Sci Pollut Res Int 2015 Apr 20;22(8):5589-91. Epub 2014 Jun 20.

FRE 3673 - Bioinspired Chemistry and Ecological Innovations - CNRS, University of Montpellier 2, Stratoz - Cap Alpha, Avenue de l'Europe, 34830, Clapiers, France,

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http://dx.doi.org/10.1007/s11356-014-3169-0DOI Listing
April 2015
9 Reads

The density matrix functional approach to electron correlation: dynamic and nondynamic correlation along the full dissociation coordinate.

J Chem Phys 2014 Jun;140(21):214105

Section Theoretical Chemistry, VU University, Amsterdam, The Netherlands.

For chemistry an accurate description of bond weakening and breaking is vital. The great advantage of density matrix functionals, as opposed to density functionals, is their ability to describe such processes since they naturally cover both nondynamical and dynamical correlation. This is obvious in the Löwdin-Shull functional, the exact natural orbital functional for two-electron systems. Read More

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http://dx.doi.org/10.1063/1.4879776DOI Listing

Chemometrics tools used in analytical chemistry: an overview.

Talanta 2014 Jun 14;123:186-99. Epub 2014 Feb 14.

Department of Pharmaceutical Analysis, Indo-Soviet College of Pharmacy (ISFCP), Moga 142001, India. Electronic address:

This article presents various important tools of chemometrics utilized as data evaluation tools generated by various hyphenated analytical techniques including their application since its advent to today. The work has been divided into various sections, which include various multivariate regression methods and multivariate resolution methods. Finally the last section deals with the applicability of chemometric tools in analytical chemistry. Read More

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http://dx.doi.org/10.1016/j.talanta.2014.02.003DOI Listing
June 2014
88 Reads

Biosensors in clinical chemistry: An overview.

Adv Biomed Res 2014 27;3:67. Epub 2014 Jan 27.

Department of Biochemistry, Mahathma Gandhi Medical College and Research Institute, Pillayarkuppam, Puducherry, India.

Biosensors are small devices that employ biological/biochemical reactions for detecting target analytes. Basically, the device consists of a biocatalyst and a transducer. The biocatalyst may be a cell, tissue, enzyme or even an oligonucleotide. Read More

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http://dx.doi.org/10.4103/2277-9175.125848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950799PMC
March 2014
4 Reads

Crystallography and chemistry: an ongoing engagement.

Angew Chem Int Ed Engl 2014 Jan;53(3):604-5

Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore 560 012 (India).

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http://dx.doi.org/10.1002/anie.201308513DOI Listing
January 2014
10 Reads