733 results match your criteria Chemistry-a European Journal[Journal]


LGBTQ+ in STEM: Visibility and Beyond.

Authors:
Joseph D Unsay

Chemistry 2020 Jun 26. Epub 2020 Jun 26.

Chemistry-A European Journal, Wiley-VCH, Boschstrasse 12, 69469, Weinheim, Germany.

Lesbian, gay, bisexual, trans, queer (LGBTQ+, "+"=plus other sexes, gender identities, and sexual orientation) people in the STEM fields (STEM=science, technology, engineering, and mathematics) continue to experience discrimination in their workplace. In the last decade, the clamor for safe and diverse spaces continue to rise. Indeed, social media plays a huge part on increasing visibility of the LGBTQ+ community in STEM. Read More

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http://dx.doi.org/10.1002/chem.202002474DOI Listing

On the Potential of Silicon as a Building Block for Life.

Life (Basel) 2020 Jun 10;10(6). Epub 2020 Jun 10.

Department of Earth, Atmospheric, and Planetary Sciences, Massachusetts Institute of Technology, 77 Mass. Ave., Cambridge, MA 02139, USA.

Despite more than one hundred years of work on organosilicon chemistry, the basis for the plausibility of silicon-based life has never been systematically addressed nor objectively reviewed. We provide a comprehensive assessment of the possibility of silicon-based biochemistry, based on a review of what is known and what has been modeled, even including speculative work. We assess whether or not silicon chemistry meets the requirements for chemical diversity and reactivity as compared to carbon. Read More

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http://dx.doi.org/10.3390/life10060084DOI Listing

Radiometric characterisation of light sources used in analytical chemistry - A review.

Anal Chim Acta 2020 Aug 24;1123:113-127. Epub 2020 Apr 24.

Australian Centre for Research on Separation Science (ACROSS) and School of Natural Sciences, University of Tasmania, Private Bag 75, Hobart 7001, Australia; Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, CZ-613 00 Brno, Czech Republic; Central European Institute of Technology, Brno University of Technology, Purkynova 123, CZ-612 00 Brno, Czech Republic.

Light sources are an indispensable component of an overwhelmingly large number of analytical methods. Radiometric characterisation of light sources in analytical chemistry is therefore of fundamental importance. This review presents up to date knowledge on methods to characterise radiometric properties of light sources in terms of radiometric power, irradiance, brightness, luminous efficacy, luminous efficiency and emission spectra, all of which are crucial parameters for their use in analytical chemistry. Read More

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http://dx.doi.org/10.1016/j.aca.2020.04.048DOI Listing

1,4-Benzodioxane, an evergreen, versatile scaffold in medicinal chemistry: A review of its recent applications in drug design.

Eur J Med Chem 2020 Aug 11;200:112419. Epub 2020 May 11.

Dipartimento di Scienze Farmaceutiche, Università di Milano, Via Mangiagalli 25, I-20133, Milano, Italy. Electronic address:

1,4-Benzodioxane has long been a versatile template widely employed to design molecules endowed with diverse bioactivities. Its use spans the last decades of medicinal chemistry until today concerning many strategies of drug discovery, not excluding the most advanced ones. Here, more than fifty benzodioxane-related lead compounds, selected from recent literature, are presented showing the different approaches with which they have been developed. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112419DOI Listing

Ice-assisted synthesis of functional nanomaterials: the use of quasi-liquid layers as nanoreactors and reaction accelerators.

Nanoscale 2020 May 27. Epub 2020 May 27.

Department of Chemistry, Division of Materials Science, Pohang University of Science and Technology (POSTECH), Pohang, Korea 790-784.

The discovery of peculiar quasi-liquid layers on ice surfaces marks a major breakthrough in ice-related sciences, as the facile tuning of the reactions and morphologies of substances in contact with these layers make ice-assisted chemistry a low-cost, environmentally benign, and ubiquitous methodology for the synthesis of nanomaterials with improved functionality. Ice-templated synthesis of porous materials offers the appealing features of rapid self-organization and remarkable property changes arising from confinement effects and affords materials that have found a diverse range of applications such as batteries, supercapacitors, and gas separation. Moreover, much attention has been drawn to the acceleration of chemical reactions and transformations on the ice surface due to the freeze concentration effect, fast self-diffusion of surface water, and modulated surface potential energy. Read More

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http://dx.doi.org/10.1039/d0nr02624gDOI Listing

Chemical Functionalization of 2D Materials.

Chemistry 2020 May;26(29):6292-6295

Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Kemigården 4, 412 96, Göteborg, Sweden.

This Special Issue of Chemistry-A European Journal is dedicated to the Chemical Functionalization of 2D Materials, and features some great contributions from experts in the field of 2D materials. This issue was originally assembled to support the Symposium G "Chemical Functionalization of 2D Materials" at the European Materials Research Society (E-MRS) 2020 Spring Meeting, which was originally scheduled to be held in Strasbourg, France, from May 25th to 29th, 2020. Although the E-MRS 2020 Spring Meeting has been cancelled due to the COVID-19 outbreak, the publication of this Special Issue has proceeded and has become even more important as the contributors discuss diverse and timely research themes related to 2D materials. Read More

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http://dx.doi.org/10.1002/chem.202001304DOI Listing

Capability of CI-Orbitrap for Gas-Phase Analysis in Atmospheric Chemistry: A Comparison with the CI-APi-TOF Technique.

Anal Chem 2020 Jun 28;92(12):8142-8150. Epub 2020 May 28.

Leibniz Institute for Tropospheric Research (TROPOS), Atmospheric Chemistry Department (ACD), Permoserstrasse 15, 04318 Leipzig, Germany.

Chemical ionization Orbitrap mass spectrometry (CI-Orbitrap) represents a promising new technique for gas-phase analysis in analytical and atmospheric chemistry mainly due to its very high mass resolving power. In this work, we performed the first side-by-side comparison between a CI-Orbitrap and the widely used atmospheric pressure interface time-of-flight mass spectrometry (CI-APi-TOF) using two different chemical ionization methods, i.e. Read More

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http://dx.doi.org/10.1021/acs.analchem.0c00111DOI Listing

CYP3A subfamily activity affects the equilibrium concentration of Phenazepam in patients with anxiety disorders and comorbid alcohol use disorder.

Pharmacogenomics 2020 May 27;21(7):449-457. Epub 2020 Apr 27.

Department of Addictology, Russian Medical Academy of Continuous Professional Education of The Ministry of Health of The Russian Federation, Moscow, 123995, Russian Federation.

Phenazepam is prescribed to relieve anxiety and sleep disorders during alcohol withdrawal, although it is associated with undesirable side effects. To demonstrate changes in the safety and efficacy profiles of Phenazepam in patients with anxiety disorders and comorbid alcohol use disorder. A total of 94 Russian patients with alcohol use disorder received 4. Read More

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http://dx.doi.org/10.2217/pgs-2019-0071DOI Listing

Frontiers and advances in environmental soil chemistry: a special issue in honor of Prof. Donald L. Sparks.

Geochem Trans 2020 Apr 17;21(1). Epub 2020 Apr 17.

Department of Soil Science, University of Saskatchewan, Saskatoon, SK, S7N 5A8, Canada.

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http://dx.doi.org/10.1186/s12932-020-00070-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164233PMC

New Insight into the Confinement Effect of Microporous Carbon in Li/Se Battery Chemistry: A Cathode with Enhanced Conductivity.

Small 2020 Apr 29;16(17):e2000266. Epub 2020 Mar 29.

College of Materials Science and Engineering, State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body, Hunan University, Tianma Rd. 27, Changsha, Hunan, 410082, China.

Embedding the fragmented selenium into the micropores of carbon host has been regarded as an effective strategy to change the Li-Se chemistry by a solid-solid mechanism, thereby enabling an excellent cycling stability in Li-Se batteries using carbonate electrolyte. However, the effect of spatial confinement by micropores in the electrochemical behavior of carbon/selenium materials remains ambiguous. A comparative study of using both microporous (MiC) and mesoporous carbons (MeC) with narrow pore size distribution as selenium hosts is herein reported. Read More

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http://dx.doi.org/10.1002/smll.202000266DOI Listing
April 2020
8.368 Impact Factor

Everolimus Rescues the Phenotype of Elastin Insufficiency in Patient Induced Pluripotent Stem Cell-Derived Vascular Smooth Muscle Cells.

Arterioscler Thromb Vasc Biol 2020 05 26;40(5):1325-1339. Epub 2020 Mar 26.

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada (C.L., D.C.R., T.T., J.E.).

Objective: Elastin gene deletion or mutation leads to arterial stenoses due to vascular smooth muscle cell (SMC) proliferation. Human induced pluripotent stem cells-derived SMCs can model the elastin insufficiency phenotype in vitro but show only partial rescue with rapamycin. Our objective was to identify drug candidates with superior efficacy in rescuing the SMC phenotype in elastin insufficiency patients. Read More

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http://dx.doi.org/10.1161/ATVBAHA.119.313936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176340PMC

Static Combinatorial Chemistry: A High-Pressure Approach to the Synthesis of Macrocyclic Benzoamide Libraries.

ACS Comb Sci 2020 04 20;22(4):213-221. Epub 2020 Mar 20.

Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.

We investigated the yield and distribution of macrocyclic products formed in combinatorial libraries (CLs) obtained via double-amidation reactions of methyl diesters with α,ω-diamines. The application of the static combinatorial chemistry (SCC) approach allowed us to generate a large number of macrocyclic diamides and tetraamides in single experiments. We show that high-pressure conditions accelerate the macrocyclization process but also have a great impact on the distribution of macrocyclic products in the presented libraries, promoting the formation of macrocyclic compounds and eliminating the linear ones. Read More

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http://dx.doi.org/10.1021/acscombsci.0c00024DOI Listing

The development of C-carbonylation chemistry: A systematic view.

Nucl Med Biol 2020 Feb 20. Epub 2020 Feb 20.

Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden.

The prospects for using carbon-11 labelled compounds in molecular imaging has improved with the development of diverse synthesis methods, including C-carbonylations and refined techniques to handle [C]carbon monoxide at a nanomole scale. Facilitating biological research and molecular imaging was the driving force when [C]carbon monoxide was used in the first in vivo application with carbon-11 in human (1945) and when [C]carbon monoxide was used for the first time as a chemical reagent in the synthesis of [C]phosgene (1978). This review examines a rich plethora of labelled compounds synthesized from [C]carbon monoxide, their chemistry and use in molecular imaging. Read More

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http://dx.doi.org/10.1016/j.nucmedbio.2020.02.005DOI Listing
February 2020
2.412 Impact Factor

Merging hypervalent iodine and sulfoximine chemistry: a new electrophilic trifluoromethylation reagent.

Chem Sci 2019 Dec 27;10(45):10516-10523. Epub 2019 Sep 27.

Institut Lavoisier de Versailles , UMR CNRS 8180 , Université de Versailles-Saint-Quentin , 45 Avenue des Etats-Unis , 78035 Versailles Cedex , France . Email:

Electrophilic trifluoromethylation is at the forefront of methodologies available for the installation of the CF moiety to organic molecules; research in this field is largely spurred by the availability of stable and accessible trifluoromethylation reagents, of which hypervalent iodine and sulfoximine based compounds have emerged as two prominent reagent classes. Herein, we describe the facile synthesis of an electrophilic trifluoromethylation reagent which merges these two scaffolds in a novel hypervalent iodosulfoximine compound. This presents the first analogue of the well-known Togni reagents which neither compromises stability or reactivity. Read More

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http://dx.doi.org/10.1039/c9sc04289jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020794PMC
December 2019

The Introduction of the Radical Cascade Reaction into Polymer Chemistry: A One-Step Strategy for Synchronized Polymerization and Modification.

iScience 2020 Mar 13;23(3):100902. Epub 2020 Feb 13.

Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, State Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 Yangqiao Road West, Fuzhou, Fujian 350002, P. R. of China. Electronic address:

Polymerization and modification play central roles in polymer chemistry and are generally implemented in two steps, which suffer from the time-consuming two-step strategy and present considerable challenge for complete modification. By introducing the radical cascade reaction (RCR) into polymer chemistry, a one-step strategy is demonstrated to achieve synchronized polymerization and complete modification in situ. Attributed to the cascade feature of iron-catalyzed three-component alkene carboazidation RCR exhibiting carbon-carbon bond formation and carbon-azide bond formation with extremely high efficiency and selectivity in one step, radical cascade polymerization therefore enables the in situ synchronized polymerization through continuous carbon-carbon bond formation and complete modification through carbon-azide bond formation simultaneously. Read More

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http://dx.doi.org/10.1016/j.isci.2020.100902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044516PMC

Recent advances in the application of layered double hydroxides in analytical chemistry: A review.

Anal Chim Acta 2020 Mar 24;1103:32-48. Epub 2019 Dec 24.

Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore. Electronic address:

In recent years, layered double hydroxides (LDHs) have garnered a lot of attention in analytical chemistry, due to their advantages such as relatively simple synthesis, low cost, possession of large specific surface area and high catalytic activity, and biocompatibility. The most common applications of LDH in analytical chemistry such as sorbents in sample extraction, electrode materials in electrochemical sensing and color indicators in colorimetric detection have been well reported. Generally, the LDHs are prepared as composites with nanomaterials, or constructed with specific three-dimensional structures, befitting the applications desired for them. Read More

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http://dx.doi.org/10.1016/j.aca.2019.12.065DOI Listing

Fiber spray ionization mass spectrometry in forensic chemistry: A screening of drugs of abuse and direct determination of cocaine in urine.

Rapid Commun Mass Spectrom 2020 Feb 13:e8747. Epub 2020 Feb 13.

Laboratório de Petroleômica e Química Forense, Departamento de Química, Universidade Federal do Espírito Santo, Vitória, ES, 29075-910, Brazil.

Rationale: Ambient mass spectrometry techniques are much required in forensic chemistry to evaluate evidence with low analytical interference, high confidence, and accuracy. However, traditional methodologies, such as paper spray ionization, have been shown to present low sensitivity in the analysis of illicit drugs from biological matrices.

Methods: Fiber spray ionization mass spectrometry (FSI-MS) was developed using a capillary polypropylene (PP) hollow fiber. Read More

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http://dx.doi.org/10.1002/rcm.8747DOI Listing
February 2020

Developmental Validation of the ANDE 6C System for Rapid DNA Analysis of Forensic Casework and DVI Samples.

J Forensic Sci 2020 Jul 10;65(4):1056-1071. Epub 2020 Feb 10.

ANDE Corporation, 266 Second Avenue, Waltham, MA, 02451.

A developmental validation was performed to demonstrate reliability, reproducibility, and robustness of the ANDE Rapid DNA Identification System for processing of crime scene and disaster victim identification (DVI) samples. A total of 1705 samples were evaluated, including blood, oral epithelial samples from drinking containers, samples on FTA and untreated paper, semen, bone, and soft tissues. This study was conducted to address the FBI's Quality Assurance Standards on developmental validation and to accumulate data from a sufficient number of unique donors and sample types to meet NDIS submission requirements for acceptance of the ANDE Expert System for casework use. Read More

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http://dx.doi.org/10.1111/1556-4029.14286DOI Listing

Fused azolo-quinoxalines: Candidates for Medicinal Chemistry. A review of their biological applications.

Curr Med Chem 2020 Feb 5. Epub 2020 Feb 5.

Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 F16, CNRS, ENSCM, Université de Montpellier, Faculté de Pharmacie, 15 avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France.

Heterocyclic compounds hold a huge and recognized place in the field of medicinal chemistry thanks to their multiple biological activities. Their synthetic pathways allow their easy and rapid access due to different bond forming methodologies and provide a huge amount of multi-functionalized compounds for drug delivery. The syntheses of heterocyclic compounds are today well known for the majority, described and reviewed in an extensive literature. Read More

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http://dx.doi.org/10.2174/0929867327666200206114936DOI Listing
February 2020

Building Knowledge Bridges through Effective Science Communication.

Chemistry 2020 Feb 30;26(8):1698-1702. Epub 2020 Jan 30.

Chemistry - A European Journal, Wiley-VCH, Boschstrasse 12, 69469, Weinheim, Germany.

The ability to communicate is fundamental to life as we know it and the key to success in many cases is based on having good communication skills. Be it written, spoken, visual, auditory or otherwise, effective communication can open many doors to hidden knowledge that can benefit the world. Science as an entity, which itself stems from the Latin word Scientia, (Engl. Read More

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http://dx.doi.org/10.1002/chem.201905685DOI Listing
February 2020

Chemical Toxicology and Medicinal Chemistry: A Special Issue Promoting Scientific Advances for Safer Medicines, Part 1.

Chem Res Toxicol 2020 01;33(1)

Department of Health Sciences and Technology ETH Zurich , 8092 Zurich , Switzerland.

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http://dx.doi.org/10.1021/acs.chemrestox.9b00496DOI Listing
January 2020

Chemistry-An Editorial Journey.

Authors:
Neville Compton

Chemistry 2020 Jan;26(1):11-13

Angewandte Chemie.

The silver anniversary of Chemistry-A European Journal is a great reason to celebrate and a good opportunity for reflection. This Editorial looks back at the history of the journal through the eyes of the Editorials written by a variety of the key players and stakeholders. Read More

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http://dx.doi.org/10.1002/chem.201905102DOI Listing
January 2020

Cutting a Gordian Knot: The Founding of Chemistry-A European Journal.

Authors:
Peter Gölitz

Chemistry 2020 Jan;26(1):9-10

Wiley-VCH, Boschstrasse 12, 69469, Weinheim, Germany.

Silver Jubilee: As Chemistry-A European Journal celebrates its 25th anniversary, Peter Gölitz looks back on the events that led to the founding of the journal. From initial concept through to successful launch, collaborations and co-operations were required to cut the Gordian Knot and make a dream of Jean-Marie Lehn and others come true. Read More

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http://dx.doi.org/10.1002/chem.201905081DOI Listing
January 2020

Chemistry-A European Journal Turns 25.

Authors:
Haymo Ross

Chemistry 2020 Jan;26(1):5-8

Wiley-VCH, Boschstrasse 12, 69469, Weinheim, Germany.

A Silver Anniversary for Chemistry-A European Journal is coming in 2020. Following on from a year of celebrating the 150th anniversary of the Periodic Table, this will mean even more special features and activities. This Editorial looks ahead at what the readers can expect from the 25th anniversary. Read More

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http://dx.doi.org/10.1002/chem.201905196DOI Listing
January 2020

Is Green Chemistry a feasible tool for the implementation of a circular economy?

Environ Sci Pollut Res Int 2020 Feb 21;27(6):6215-6227. Epub 2019 Dec 21.

Universidad San Jorge, Villanueva de Gállego, 50830, Zaragoza, Spain.

The main goal of this research is to evaluate the contributions of Green Chemistry as a potential tool to drive the transition to circularity. For this, we have carried out a bibliographic study, analyzing those documents, process, or experiences that dealt jointly with the Green Chemistry aspects related to circularity such circular economy, industrial ecology, and closed loop. Findings show that few authors have treated that disciplines together in the last 10 years. Read More

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http://dx.doi.org/10.1007/s11356-019-07177-5DOI Listing
February 2020

Redox-neutral -C-H amination of pinacol arylborates palladium(ii)/norbornene catalysis for aniline synthesis.

Chem Sci 2019 Sep 23;10(36):8384-8389. Epub 2019 Jul 23.

Sauvage Center for Molecular Sciences , Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education) , College of Chemistry and Molecular Sciences , Wuhan University , Wuhan , 430072 , China.

A palladium(ii)/norbornene cooperative catalysis enabled redox-neutral -C-H amination of pinacol aryl- or heteroarylborates for the synthesis of structurally diverse anilines is reported. This method is scalable, robust (tolerance of air and moisture), phosphine ligand-free, and compatible with a wide range of functionalities. These practical features make this reaction amenable for industry. Read More

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http://dx.doi.org/10.1039/c9sc02759aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839810PMC
September 2019

The Physics of Plasma Ion Chemistry: A Case Study of Plasma Polymerization of Ethyl Acetate.

J Phys Chem Lett 2019 Dec 13;10(23):7306-7310. Epub 2019 Nov 13.

Future Industries Institute , University of South Australia , Mawson Lakes Campus, Mawson Lakes , Australia , 5095.

Deposition chemistry from plasma is highly dependent on both the chemistry of the ions arriving at surfaces and the ion energy. Typically, when measuring the energy distribution of ions arriving at surfaces from plasma, it is assumed that the distributions are the same for all ionic species. Using ethyl acetate as a representative organic precursor molecule, we have measured the ion chemistry and ion energy as a function of pressure and power. Read More

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http://dx.doi.org/10.1021/acs.jpclett.9b02855DOI Listing
December 2019

Use of Deep Eutectic Solvents in Polymer Chemistry-A Review.

Molecules 2019 Nov 3;24(21). Epub 2019 Nov 3.

Department of Inorganic Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Radlinskeho 9, Bratislava SK-812 37, Slovakia.

This review deals with two overlapping issues, namely polymer chemistry and deep eutectic solvents (DESs). With regard to polymers, specific aspects of synthetic polymers, polymerization processes producing such polymers, and natural cellulose-based nanopolymers are evaluated. As for DESs, their compliance with green chemistry requirements, their basic properties and involvement in polymer chemistry are discussed. Read More

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http://dx.doi.org/10.3390/molecules24213978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864848PMC
November 2019

Physical Chemistry, a Discipline in Its Golden Age.

Authors:
Alexander Kuhn

Chemphyschem 2020 Jan 17;21(1):7-8. Epub 2019 Oct 17.

Univ. Bordeaux, ISM UMR CNRS 5255, Bordeaux INP, ENSCBP, 16 avenue Pey Berland, 33607, Pessac, France.

Alexander Kuhn is Full Professor at the Institute of Molecular Science (University Bordeaux, CNRS, Bordeaux INP) as well as Adjunct Professor at VISTEC (Thailand) and Henan University (China). He currently serves as a chair of the ChemPhysChem Editorial Board. Read More

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http://dx.doi.org/10.1002/cphc.201900932DOI Listing
January 2020

The effect of coordination of alkanes, Xe and CO (η-OCO) on changes in spin state and reactivity in organometallic chemistry: a combined experimental and theoretical study of the photochemistry of CpMn(CO).

Faraday Discuss 2019 Dec;220(0):86-104

School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.

A combined experimental and theoretical study is presented of several ligand addition reactions of the triplet fragment 3CpMn(CO)2 formed upon photolysis of CpMn(CO)3. Experimental data are provided for reactions in n-heptane and perfluoromethylcyclohexane (PFMCH), as well as in PFMCH doped with C2H6, Xe and CO2. In PFMCH we find that the conversion of 3CpMn(CO)2 to 1CpMn(CO)2(PFMCH) is much slower (τ = 18 (±3) ns) than the corresponding reactions in conventional alkanes (τ = 111 (±10) ps). Read More

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http://dx.doi.org/10.1039/c9fd00067dDOI Listing
December 2019
4.606 Impact Factor

Brain Prostaglandin D2 Increases Neurogenic Pressor Activity and Mean Arterial Pressure in Angiotensin II-Salt Hypertensive Rats.

Hypertension 2019 12 7;74(6):1499-1506. Epub 2019 Oct 7.

Department of Pharmacology and Toxicology (N.A.-J., R.B., G.D.F.), Michigan State University, East Lansing.

This study tested whether brain L-PGDS (lipocalin-type prostaglandin [PG] D synthase), through prostanoid signaling, might increase neurogenic pressor activity and thereby cause hypertension. Sprague Dawley rats on high-salt diet received either vehicle or Ang II (angiotensin II) infusion. On day 4, the developmental stage of hypertension, brains from different sets of control and Ang II-treated rats were collected for measuring L-PGDS expression, PGD2 levels, and DP1R (type 1 PGD2 receptor) expression. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.
Publisher Site
http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.13175DOI Listing
December 2019
6 Reads

The Basis for Strain-Dependent Rat Aldehyde Dehydrogenase 1A7 () Gene Expression.

Mol Pharmacol 2019 11 1;96(5):655-663. Epub 2019 Oct 1.

Departments of Pharmacology (K.T., M.K., P.P.) and Clinical Chemistry (A.M.), Faculty of Medicine, School of Health Sciences, University of Ioannina, and Department of Biomedical Research, Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology (A.M.), Ioannina, Greece; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (J.K., F.M., M.R., P.H.);Department of Biology, School of Science and Technology, Nazarbayev University, Nur-Sultan City, Kazakhstan (F.M.); Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (P.H.)

Aldehyde hydrogenases (ALDHs) belong to a large gene family involved in oxidation of both endogenous and exogenous compounds in mammalian tissues. Among ALDHs, the rat gene displays a curious strain dependence in phenobarbital (PB)-induced hepatic expression: the responsive strains exhibit induction of both ALDH1A7 and CYP2B mRNAs and activities, whereas the nonresponsive strains show induction of CYP2B only. Here, we investigated the responsiveness of , , and genes to prototypical P450 inducers, expression of nuclear receptors CAR and pregnane X receptor, and structure of the promoter in both rat strains. Read More

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http://dx.doi.org/10.1124/mol.119.117424DOI Listing
November 2019

Citation Bribery.

Authors:
Haymo Ross

Chemistry 2019 Oct 26;25(59):13449-13451. Epub 2019 Sep 26.

Chemistry-A European Journal, Wiley-VCH, Boschstr. 12, 69469, Weinheim, Germany.

How can the importance of a journal possibly be pinned down to a single number? The 2018 Impact Factors were released on June 20, 2019. In this editorial Haymo Ross, Editor-in-Chief of the Chemistry-A European Journal, shares some his thoughts on this topic. Read More

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http://dx.doi.org/10.1002/chem.201903777DOI Listing
October 2019

C-X-C Ligand 16 Is an Independent Predictor of Cardiovascular Death and Morbidity in Acute Coronary Syndromes.

Arterioscler Thromb Vasc Biol 2019 11 26;39(11):2402-2410. Epub 2019 Sep 26.

Department of Cardiology, Stavanger University Hospital, Norway (F.K.).

Objective: The chemokine CXCL16 (C-X-C motif ligand 16) is a scavenger receptor for OxLDL (oxidized low-density lipoproteins) and involved in inflammation at sites of atherosclerosis. This study aimed to investigate the association of CXCL16 with clinical outcome in patients with acute coronary syndrome. Approach and Results: Serial measurements of CXCL16 were performed in a subgroup of 5142 patients randomized in the PLATO trial (Platelet Inhibition and Patient Outcome). Read More

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http://dx.doi.org/10.1161/ATVBAHA.119.312633DOI Listing
November 2019
3 Reads

Design And Molecular Docking Studies Of Some 2, 3 Di-Substituted Quinazolin-4-One Analogues Against Staphylococcus aureus UDG.

Curr Comput Aided Drug Des 2019 Sep 15. Epub 2019 Sep 15.

Department of Pharmaceutical Chemistry M.G.V`s Samajshri Prashantdada Hiray College of Pharmacy, Malegaon, Nashik, Maharashtra. India.

In this present investigation of some 2, 3 disubstituted-quinazolin-4-one derivatives are designed and docked against chain A and chain B of (3WDF) receptor. The heterocyclic fused rings quinazolinone has drawn a huge consideration owing to their expanded applications in the field of pharmaceutical chemistry A diverse range of molecules with quinazoline/quinazolinone moieties have been reported to exhibit broad spectrum of biological activities. The results designate that the quinazolinone ring forms hydrophobic and hydrogen bond contacts with ASN 127 A, ALA 126 A, and SER 83 B, SER 183 B amino acid residue. Read More

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http://dx.doi.org/10.2174/1573409915666190916100437DOI Listing
September 2019
4 Reads

Variations in meat colour due to factors other than myoglobin chemistry; a synthesis of recent findings (invited review).

Meat Sci 2020 Jan 4;159:107941. Epub 2019 Sep 4.

CSIRO Agriculture and Food, 39 Kessels Rd, Coopers Plains, QLD 4108, Australia.

This review focuses on the mechanisms responsible for some the achromatic aspects of meat colour (paleness or darkness) due to light scatter from structures within the tissue. Recent investigations have highlighted the role of three key mechanisms contributing to variations in the lightness of meat: (1) Variations in the myofilament lattice spacing, and the resultant changes in myofibril diameter and muscle fibre diameter. A 20% increase in lightness (L* value) between muscles with ultimate pH of 6. Read More

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http://dx.doi.org/10.1016/j.meatsci.2019.107941DOI Listing
January 2020
2.615 Impact Factor

Z-isomerization of retinoids through combination of monochromatic photoisomerization and metal catalysis.

Org Biomol Chem 2019 09 28;17(35):8125-8139. Epub 2019 Aug 28.

Gavin Herbert Eye Institute and the Department of Ophthalmology, University of California, Irvine, California 92697, USA.

Catalytic Z-isomerization of retinoids to their thermodynamically less stable Z-isomer remains a challenge. In this report, we present a photochemical approach for the catalytic Z-isomerization of retinoids using monochromatic wavelength UV irradiation treatment. We have developed a straightforward approach for the synthesis of Z-retinoids in high yield, overcoming common obstacles normally associated with their synthesis. Read More

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http://dx.doi.org/10.1039/c9ob01645gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739180PMC
September 2019
3 Reads

A Comprehensive Review of Non-Covalent Radiofluorination Approaches Using Aluminum [F]fluoride: Will [F]AlF Replace Ga for Metal Chelate Labeling?

Molecules 2019 Aug 7;24(16). Epub 2019 Aug 7.

CERIMED, Aix-Marseille University, 13005 Marseille, France.

Due to its ideal physical properties, fluorine-18 turns out to be a key radionuclide for positron emission tomography (PET) imaging, for both preclinical and clinical applications. However, usual biomolecules radiofluorination procedures require the formation of covalent bonds with fluorinated prosthetic groups. This drawback makes radiofluorination impractical for routine radiolabeling, gallium-68 appearing to be much more convenient for the labeling of chelator-bearing PET probes. Read More

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http://dx.doi.org/10.3390/molecules24162866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719958PMC

Surface chemistry and reactivity of α-MoO toward methane: A SCAN-functional based DFT study.

J Chem Phys 2019 Jul;151(4):044708

Department of Chemistry and Biochemistry, Southern Illinois University, Carbondale, Illinois 62901, USA.

Molybdenum trioxide (α-MoO) is a key component in the redox solid catalysts for methane activation. The wide range of interactions including van der Waals interaction and chemical bonding in α-MoO as well as between methane and the catalyst surface makes the accurate description of the methane chemistry a challenge. Herein, we performed a strongly constrained and appropriately normed (SCAN)-functional based density functional theory study of the surface chemistry and reactivity of α-MoO toward C-H bond activation of methane. Read More

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http://dx.doi.org/10.1063/1.5113787DOI Listing
July 2019
2.952 Impact Factor

Visualization analysis of graphene and its composites for heavy metal wastewater applications.

Environ Sci Pollut Res Int 2019 Sep 23;26(27):27752-27760. Epub 2019 Jul 23.

School of Resources and Environmental Engineering, Wuhan University of Technology, Wuhan, 430070, China.

In order to explore the research trends and hotspots related to the treatment of heavy metals in wastewater by graphene and its composites, this study collected information on 511 publications from the Science Citation Index-Expanded (SCIE) and conducted a quantitative and visual analysis. The article on the adsorption of heavy metals in wastewater by graphene and its composites first appeared in 2006 and continued to grow since 2011. It broke through 100 articles for the first time in 2016 and the overall trend is on the rise. Read More

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http://dx.doi.org/10.1007/s11356-019-05983-5DOI Listing
September 2019
2 Reads
2.828 Impact Factor

The Rise of Phosphaethynolate Chemistry in Early Transition Metals, Actinides, and Rare-Earth Complexes.

Chemistry 2019 Dec 11;25(71):16171-16178. Epub 2019 Oct 11.

Department of Chemistry, University of Pennsylvania, Philadelphia, PA, 19104, USA.

In the last seven years, chemistry of the phosphaethynolate reagent, Na(OCP)(1,4-dioxane) , has seen a surge in organic and inorganic chemistry-A renaissance to cyanate chemistry in a new guise. Whereas there have been many reports of main group reactivity with [OCP] , largely from group 14, in more recent times the use of electropositive metals has garnered significant interest given their ability to disguise in various oxidation states. Herein, we report and discuss advances in such studies of [OCP] with early transition metal and f-block metal scaffolds. Read More

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http://dx.doi.org/10.1002/chem.201902871DOI Listing
December 2019
1 Read

1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview.

Bioorg Med Chem 2019 08 4;27(16):3511-3531. Epub 2019 Jul 4.

Key Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 40-1 South Beijing Rd, Urumqi 830011, PR China. Electronic address:

The 1,2,3-triazole ring is a major pharmacophore system among nitrogen-containing heterocycles. These five-membered heterocyclic motifs with three nitrogen heteroatoms can be prepared easily using 'click' chemistry with copper- or ruthenium-catalysed azide-alkyne cycloaddition reactions. Recently, the 'linker' property of 1,2,3-triazoles was demonstrated, and a novel class of 1,2,3-triazole-containing hybrids and conjugates was synthesised and evaluated as lead compounds for diverse biological targets. Read More

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http://dx.doi.org/10.1016/j.bmc.2019.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185471PMC
August 2019
14 Reads

Ultrahigh Performance Mass Spectrometry in Clinical Chemistry: A Taste of the Future?

Clin Chem 2019 08 24;65(8):943-945. Epub 2019 Jun 24.

Division of Laboratory Medicine, Geneva University Hospitals, Geneva, Switzerland;

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http://dx.doi.org/10.1373/clinchem.2019.305631DOI Listing
August 2019
1 Read

Chemotherapy Based on Supramolecular Chemistry: A Promising Strategy in Cancer Therapy.

Pharmaceutics 2019 Jun 20;11(6). Epub 2019 Jun 20.

Department of Chemistry, American University in Cairo (AUC), AUC Avenue, P.O. Box 74, New Cairo 11835, Egypt.

Chemotherapeutic agents are considered one of the strategies in treating cancer. However, their use is faced by many challenges, such as poor water solubility leading to poor bioavailability and non-selective targeting of cancerous cells leading to diminished therapeutic actions and systemic adverse effects. Many approaches were adopted to overcome these drawbacks and to achieve the targeted delivery of the chemotherapeutic agents to the cancerous cells while minimizing adverse effects. Read More

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http://dx.doi.org/10.3390/pharmaceutics11060292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631471PMC
June 2019
14 Reads

Fluorescent Isoindole Crosslink (FlICk) Chemistry: A Rapid, User-friendly Stapling Reaction.

Angew Chem Int Ed Engl 2019 10 18;58(40):14120-14124. Epub 2019 Jul 18.

Chemistry Department, UBC, 2036 Main Mall, Vancouver, B.C., V6T1Z1, Canada.

The stabilization of peptide secondary structure via stapling is a ubiquitous goal for creating new probes, imaging agents, and drugs. Inspired by indole-derived crosslinks found in natural peptide toxins, we employed ortho-phthalaldehydes to create isoindole staples, thus transforming inactive linear and monocyclic precursors into bioactive monocyclic and bicyclic products. Mild, metal-free conditions give an array of macrocyclic α-melanocyte-stimulating hormone (α-MSH) derivatives, of which several isoindole-stapled α-MSH analogues (K ≈1 nm) are found to be as potent as α-MSH. Read More

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http://dx.doi.org/10.1002/anie.201906514DOI Listing
October 2019
13 Reads

Copper-Catalyzed Oxidative Multicomponent Annulation Reaction for Direct Synthesis of Quinazolinones via an Imine-Protection Strategy.

Org Lett 2019 06 3;21(12):4725-4728. Epub 2019 Jun 3.

Key Lab of Functional Molecular Engineering of Guangdong Province and Guangdong Engineering Research Center for Green Fine Chemicals, School of Chemistry and Chemical Engineering , South China University of Technology , Guangzhou , 510640 , P. R. China.

Via an imine-protection strategy, we herein present an unprecedented copper-catalyzed oxidative multicomponent annulation reaction for direct synthesis of quinazolinones. The construction of various products is achieved via formation of three C-N and one C-C bonds in conjunction with the benzylic functionalization. The merits of easily available feedstocks, naturally abundant catalyst, good functional group and substrate compatibility, and release of HO as the byproduct make the developed chemistry a practical way to access quinazolinones. Read More

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http://dx.doi.org/10.1021/acs.orglett.9b01608DOI Listing
June 2019
13 Reads

Research trends in food chemistry: A bibliometric review of its 40 years anniversary (1976-2016).

Food Chem 2019 Oct 4;294:448-457. Epub 2019 May 4.

Food Science and Nutrition Program, Institute of Biochemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada.

This study presents a general bibliometric overview of the major scientific developments that have been published in Food Chemistry, since its first issue (1976). The bibliometric data were retrieved from the scopus database. The review identifies the most cited, productive authors, and the leading institutions and countries of the journal, based on bibliometric indicators. Read More

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http://dx.doi.org/10.1016/j.foodchem.2019.05.021DOI Listing
October 2019
7 Reads
3.391 Impact Factor

Allosteric Agonism of 7 Nicotinic Acetylcholine Receptors: Receptor Modulation Outside the Orthosteric Site.

Mol Pharmacol 2019 06 3;95(6):606-614. Epub 2019 Apr 3.

Departments of Chemistry (A.G., M.Q., N.A.H.) and Pharmacology and Therapeutics (R.L.P, C.S., M.Q.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., G.A.T.)

Nicotinic acetylcholine receptors (nAChRs) are members of the Cys-loop superfamily of ligand-gated ion channels. Typically, channel activation follows the binding of agonists to the orthosteric binding sites of the receptor. 7 nAChRs have a very low probability of channel activation, which can be reversed by the binding of 7 selective positive allosteric modulators (PAMs) to putative sites within the transmembrane domains. Read More

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http://molpharm.aspetjournals.org/lookup/doi/10.1124/mol.119
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http://dx.doi.org/10.1124/mol.119.115758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491904PMC
June 2019
12 Reads