4,627,288 results match your criteria Chemistry of materials : a publication of the American Chemical Society[Journal]


Protein microspheres as structuring agents in lipids: potential for reduction of total and saturated fat in food products.

J Sci Food Agric 2020 Jul 6. Epub 2020 Jul 6.

Life Quality Engineering Interest Group, School of Chemical and Environmental Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China.

Excess consumption of total and saturated fats is linked to the development of chronic diseases, such as obesity, heart disease, diabetes, and cancer. There is therefore considerable interest in the development of foods containing lower levels of total and saturated fats, but that still have the same desirable physicochemical and sensory characteristics as the original foods. Solid fats normally contribute a number of key functional attributes to foods due to their ability to form crystalline networks that alter texture (such as elasticity, plasticity, and spreadability) and appearance (such as opacity and creaminess). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jsfa.10645DOI Listing

Cannabinoids and Cannabinoid Receptors: The Story so Far.

iScience 2020 Jun 20;23(7):101301. Epub 2020 Jun 20.

Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON N9B 3P4, Canada. Electronic address:

Like most modern molecular biology and natural product chemistry, understanding cannabinoid pharmacology centers around molecular interactions, in this case, between the cannabinoids and their putative targets, the G-protein coupled receptors (GPCRs) cannabinoid receptor 1 (CB) and cannabinoid receptor 2 (CB). Understanding the complex structure and interplay between the partners in this molecular dance is required to understand the mechanism of action of synthetic, endogenous, and phytochemical cannabinoids. This review, with 91 references, surveys our understanding of the structural biology of the cannabinoids and their target receptors including both a critical comparison of the extant crystal structures and the computationally derived homology models, as well as an in-depth discussion about the binding modes of the major cannabinoids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.isci.2020.101301DOI Listing

Contrasting effects of Cr(III) and Cr(VI) on lettuce grown in hydroponics and soil: Chromium and manganese speciation.

Authors:
Jin Hee Park

Environ Pollut 2020 Jun 23;266(Pt 2):115073. Epub 2020 Jun 23.

Department of Environmental & Biological Chemistry, Chungbuk National University, Cheongju, Chungbuk, 28644, Republic of Korea. Electronic address:

Chromium (Cr) is a toxic element among which hexavalent chromium [Cr(VI)] is more toxic than trivalent chromium [Cr(III)]. Chromium can be reduced or oxidized in soil because soil is a complex medium and various soil components affect redox reaction of Cr in soil. Therefore, Cr speciation in hydroponics and soil was compared and Cr uptake and speciation by lettuce grown in the media were evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envpol.2020.115073DOI Listing

Cu-selective NIR fluorescence sensor based on heptamethine cyanine in aqueous media and its application.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 19;240:118606. Epub 2020 Jun 19.

Department of Chemistry, Faculty of Science, Silpakorn University, Nakhon Pathom 73000, Thailand. Electronic address:

A near-infrared (NIR) colorimetric fluorescence sensor, Cy7C3, based on heptamethine cyanine dye was synthesized for determining the presence of Cu ions. The sensor showed highly sensitive fluorescence quenching toward Cu ions in acetonitrile/buffer solution at physiological pH with long emission wavelength of 718 nm. Cy7C3 also provided an excellent selectivity to Cu ions over other competing metal ions, with a low detection limit of 9 ppb, which was lower than the maximum concentration of Cu ions in drinking water of U. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.saa.2020.118606DOI Listing

Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma.

EBioMedicine 2020 Jul 3;57:102846. Epub 2020 Jul 3.

Department of Internal Medicine, National Taiwan University Hospital, No. 7, Zhongshan S Rd, Zhongzheng District, Taipei 10002, Taiwan; Graduate Institute of Toxicology, College of Medicine, National Taiwan University, No. 1, Jen Ai Rd, Section 1, Zhongzheng District, Taipei 10051, Taiwan. Electronic address:

Background: Aberrant fucosylation plays a critical role in lung cancer progression. Nevertheless, the key fucosyltransferase with prognostic significance in lung cancer patients, the enzyme's intracellular targets, and complex molecular mechanisms underlying lung cancer metastasis remain incompletely understood.

Methods: We performed a large-scale transcriptome-clinical correlation to identify major fucosyltransferases with significant prognostic values. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2020.102846DOI Listing

Inductively coupled plasma nanosilica based growth method for enhanced biomass production in marine diatom algae.

Bioresour Technol 2020 Jun 29;314:123747. Epub 2020 Jun 29.

Diatom Research Laboratory, Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh 201 313, India. Electronic address:

This work reports a novel solution-based method to trigger the growth of diatoms for enhanced biomass production, which can efficiently stimulate their applications in nutraceuticals, aquaculture and wastewater remediation. The optimization for the growth of three marine diatoms species was performed using inductively coupled plasma (ICP) synthesized nanosilica which can be a cost-effective and productive method for biomass production. The exponential growth phase was achieved in 14 days with high biomass productivity compared to F/2-Si Media [Chaetoceros sp. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biortech.2020.123747DOI Listing

Modification of rapeseed protein by ultrasound-assisted pH shift treatment: Ultrasonic mode and frequency screening, changes in protein solubility and structural characteristics.

Ultrason Sonochem 2020 Jun 29;69:105240. Epub 2020 Jun 29.

School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China; Institute of Food Physical Processing , Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China.

We investigated the effect of ultrasound-assisted pH shift treatment on the micro-particle, molecular, and spatial structure of rapeseed protein isolates (RPI). Various ultrasonic frequency modes (fixed, and sweep) was used. Protein characterization by the indexes: particle size, zeta potential, sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), scanning electron microscopy (SEM), free sulfhydryl (SH), surface hydrophobicity (Ho), Fourier transform infrared Spectrum (FTIR) and fluorescence intensity was studied to elucidate the changes in solubility and structural attributes of RPI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ultsonch.2020.105240DOI Listing

Pd-based catalysts promoted by hierarchical porous AlO and ZnO microsphere supports/coatings for ethyl acetate highly active and stable destruction.

J Hazard Mater 2020 Jun 22;401:123281. Epub 2020 Jun 22.

College of Resource and Environmental Engineering, Guizhou University, Guiyang, 550025, PR China. Electronic address:

Developing economical and active materials is of great significance for VOC purification. Here, hierarchical porous AlO and ZnO microspheres (AlO-pm and ZnO-pm) were synthesized by a facile hydrothermal strategy. The urchin-like AlO-pm and flower-like ZnO-pm possess high specific surface area (especially; external surface area) obviously boost the dispersion of Pd with 29. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhazmat.2020.123281DOI Listing

A novel pipeline of 2-(benzenesulfonamide)-N-(4-hydroxyphenyl) acetamide analgesics that lack hepatotoxicity and retain antipyresis.

Eur J Med Chem 2020 Jun 30;202:112600. Epub 2020 Jun 30.

Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA, 70112, USA.

Although acetaminophen (ApAP) is one of the most commonly used medicines worldwide, hepatotoxicity is a risk with overdose or in patients with compromised liver function. ApAP overdose is the most common cause of acute fulminant hepatic failure. Oxidation of ApAP to N-acetyl-p-benzoquinone imine (NAPQI) is the mechanism for hepatotoxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2020.112600DOI Listing

White wine processing by UHPH without SO. Elimination of microbial populations and effect in oxidative enzymes, colloidal stability and sensory quality.

Food Chem 2020 Jun 27;332:127417. Epub 2020 Jun 27.

enotecUPM, Chemistry and Food Technology Department, ETSIAAB, Universidad Politécnica de Madrid, Avenida Complutense S/N, 28040 Madrid, Spain. Electronic address:

The use of UHPH sterilization in the absence of SO has been used to eliminate wild microorganisms and inactivate oxidative enzymes. A white must of the Muscat of Alexandria grape variety was continuously processed by UHPH at 300 MPa (inlet temperature: 23-25 °C). The initial microbial load of the settled must was 4-log CFU/mL for both yeast and moulds, and slightly lower for bacteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.foodchem.2020.127417DOI Listing

Simultaneous generation of acrylamide, β-carboline heterocyclic amines and advanced glycation ends products in an aqueous Maillard reaction model system.

Food Chem 2020 Jun 20;332:127387. Epub 2020 Jun 20.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, PR China; International Joint Laboratory on Food Safety, Jiangnan University, Wuxi, Jiangsu 214122, China. Electronic address:

The simultaneous formation of acrylamide; β-carboline heterocyclic amines (HAs): harmane and norharmane; and advanced glycation end products (AGEs) (N-(carboxymethyl)lysine (CML) and N-(carboxyethyl)lysine (CEL)) was analyzed based on an aqueous model system. The model systems included lysine-glucose (Lys/Glu), asparagine-glucose (Asn/Glu), tryptophan-glucose (Trp/Glu), and a mixture of these amino acids (Mix/Glu). Only AGEs were generated when heated at 100 °C, Asn and Trp competed with Lys for glucose and methylglyoxal (MGO), and glyoxal (GO) decreased AGE content. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.foodchem.2020.127387DOI Listing

Degradation and deactivation of a plasmid-encoded extracellular antibiotic resistance gene during separate and combined exposures to UV and radicals.

Water Res 2020 May 16;182:115921. Epub 2020 May 16.

School of Earth Sciences and Environmental Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, Republic of Korea. Electronic address:

This study investigated the degradation and deactivation of an extracellular ampicillin resistance gene (amp) encoded in plasmid pUC19 during exposure to UV, OH (generated by UV/HO), and combined exposure to UV and OH (and/or SO) using UV/HO and UV/SO. The degradation rates of amp measured by quantitative polymerase chain reaction increased with increasing target amplicon length (192-851 bps). The rate constants for the degradation of pUC19 (2686 bps) were calculated as 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.watres.2020.115921DOI Listing

Microplastic pollution research methodologies, abundance, characteristics and risk assessments for aquatic biota in China.

Environ Pollut 2020 Jun 30;266(Pt 3):115098. Epub 2020 Jun 30.

Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou, 510642, China; Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Guangxi Academy of Sciences, Nanning, 530007, China. Electronic address:

The widespread presence of microplastics in global aquatic ecosystems has aroused growing concern about the potential impacts of microplastics on aquatic biota. In marine and freshwater environments, microplastics are distributed pervasively within water bodies from the upper water column to the bottom layer, making them available to a large variety of aquatic organisms that inhabit different locations. The ingestion of microplastic particles may cause harm to aquatic organisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envpol.2020.115098DOI Listing

Accurate EELS background subtraction - an adaptable method in MATLAB.

Ultramicroscopy 2020 Jun 25;217:113052. Epub 2020 Jun 25.

Department of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom; Nanoscale and Microscale Research Centre, Cripps South, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ultramic.2020.113052DOI Listing

Evaluation of hypopigmentation in embryonic zebrafish induced by emerging disinfection byproduct, 3, 5-di-I-tyrosylalanine.

Aquat Toxicol 2020 Jun 23;225:105525. Epub 2020 Jun 23.

Key Laboratory of Optoelectronic Chemical Materials and Devices, Jianghan University, Wuhan 430056, China. Electronic address:

Halogenated dipeptides, 3, 5-di-I-tyrosylalanine (DIYA), have been identified as novel disinfection byproducts (DBPs), following chloramination of authentic water. However, little is known about their toxicity. Zebrafish embryos were used to assess the toxicity of novel iodinated DBPs (I-DBPs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aquatox.2020.105525DOI Listing

Norcolocynthenins A and B, two cucurbitane 3-nor-Triterpenoids from Citrullus colocynthis and their cytotoxicity.

Bioorg Chem 2020 Jun 25;101:104045. Epub 2020 Jun 25.

The Laboratory of Effective Substances of Jiangxi Genuine Medicinal Materials, College of Life Sciences, Jiangxi Normal University, Nanchang330022, China; The Key Laboratory of Plant Resources and Chemistry of Arid Zone, State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China. Electronic address:

Two novel cucurbitane 3-nor-triterpenoids, named norcolocynthenins A (1) and B (2), were isolated from the fruits of Citrullus colocynthis. The structures including their absolute configurations were determined by extensive spectroscopic analyses and theoretical calculations. Compound 1 features an unprecedented 5/6/6/5-fused ring system while compound 2 possesses a rare lactone moiety at modified ring A. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bioorg.2020.104045DOI Listing

N-methoxy-β-carboline alkaloids with inhibitory activities against Aβ aggregation and acetylcholinesterase from the stems of Picrasma quassioides.

Bioorg Chem 2020 Jun 25;101:104043. Epub 2020 Jun 25.

Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China; College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address:

Nine new N-methoxy-β-carboline alkaloids (NMCAs) (1a/1b-3a/3b and 4-6) and two known NMCAs (7 and 8) were isolated from the stems of Picrasma quassioides. Their structures were elucidated by spectroscopic data analyses, quantum chemical calculations, and single-crystal X-ray crystallographic data. An analysis of the C NMR chemical shifts of the N-methoxy groups in these NMCAs and 41 gathered known compounds reveals the phenomenon that the chemical shifts of all these N-methoxy groups are greater than δ 62, which can be used to recognize the N-methoxy group rapidly. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bioorg.2020.104043DOI Listing

Optimization strategy of single-digit nanomolar cross-class inhibitors of mammalian and protozoa cysteine proteases.

Bioorg Chem 2020 Jun 24;101:104039. Epub 2020 Jun 24.

Medicinal and Biological Chemistry Group, Institute of Chemistry of São Carlos, University of São Paulo, Avenue Trabalhador Sancarlense, 400, 23566-590 São Carlos, SP, Brazil. Electronic address:

Cysteine proteases (CPs) are involved in a myriad of actions that include not only protein degradation, but also play an essential biological role in infectious and systemic diseases such as cancer. CPs also act as biomarkers and can be reached by active-based probes for diagnostic and mechanistic purposes that are critical in health and disease. In this paper, we present the modulation of a CP panel of parasites and mammals (Trypanosoma cruzi cruzain, LmCPB, CatK, CatL and CatS), whose inhibition by nitrile peptidomimetics allowed the identification of specificity and selectivity for a given CP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bioorg.2020.104039DOI Listing

8-Benzylaminoxanthine scaffold variations for selective ligands acting on adenosine A receptors. Design, synthesis and biological evaluation.

Bioorg Chem 2020 Jun 19;101:104033. Epub 2020 Jun 19.

Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30688 Kraków, Poland. Electronic address:

A library of 34 novel compounds based on a xanthine scaffold was explored in biological studies for interaction with adenosine receptors (ARs). Structural modifications of the xanthine core were introduced in the 8-position (benzylamino and benzyloxy substitution) as well as at N1, N3, and N7 (small alkyl residues), thereby improving affinity and selectivity for the A AR. The compounds were characterized by radioligand binding assays, and our study resulted in the development of the potent A AR ligands including 8-((6-chloro-2-fluoro-3-methoxybenzyl)amino)-1-ethyl-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione (12d; K human AAR: 68. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bioorg.2020.104033DOI Listing

Anticancer potential of new 3-nitroaryl-6-(N-methyl)piperazin-1,2,4-triazolo[3,4-a]phthalazines targeting voltage-gated K channel: Copper-catalyzed one-pot synthesis from 4-chloro-1-phthalazinyl-arylhydrazones.

Bioorg Chem 2020 Jun 19;101:104031. Epub 2020 Jun 19.

Department of Chemistry, University of Florida, Gainesville, FL, United States. Electronic address:

A series of six 3-aryl-6-(N-methylpiperazin)-1,2,4-triazolo[3,4-a]phthalazines were prepared through a facile and efficient one-pot copper-catalyzed procedure from 4-chloro-1-phthalazinyl-arylhydrazones with relatively good yields (62-83%). The one-pot copper-catalytic procedure consists of two simultaneous reactions: (i) a direct intramolecular dehydrogentaive cyclization between ylidenic carbon and adjacent pyrazine nitrogen to form 1,2,4-triazolo ring and, (ii) a direct N-amination on carbon-chlorine bond. Then, an in vitro anticancer evaluation was performed for the synthesized compounds against five selected human cancer cells (A549, MCF-7, SKBr3, PC-3 and HeLa). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bioorg.2020.104031DOI Listing

COVID19 inhibitors: A prospective therapeutics.

Authors:
Md Jawaid Akhtar

Bioorg Chem 2020 Jun 17;101:104027. Epub 2020 Jun 17.

Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ghal Kalan, Ferozpur G.T. Road, Moga 142001, Punjab, India. Electronic address:

The inhibition of viral targets might provide new therapies for coronavirus disease abbreviated as COVID-19. The rational drug design identified as much of the recent discoveries of potent drugs molecule against any targets. This results in an improvement in bindings for better potency and selectivity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bioorg.2020.104027DOI Listing

Design, synthesis and biological evaluation of novel 2-alkylidene 19-norcalcitriol analogs.

Bioorg Chem 2020 Jun 12;101:104013. Epub 2020 Jun 12.

Department of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland. Electronic address:

Continuing our studies aimed at A-ring modified vitamin D compounds, we designed novel 19-norcalcitriol derivatives bearing at C-2 pegylated chains of different lengths. The terminal fragments of these substituents contain hydroxyls or moieties possessing nitrogen and/or sulfur atoms capable of transition metal ions complexation. Also, two conjugate-type platinum(II) complexes of 19-norcalcitriol were obtained in which l-methionine served as chelating moiety. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bioorg.2020.104013DOI Listing

Bioactive triterpenoids from Lantana camara showing anti-inflammatory activities in vitro and in vivo.

Bioorg Chem 2020 Jun 10;101:104004. Epub 2020 Jun 10.

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, and Drug Discovery Center for Infectious Disease, Nankai University, Tianjin 300050, People's Republic of China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, People's Republic of China. Electronic address:

Bioactive natural products play an important role in the research and development of new drugs. In our search for bioactive natural substances as potential lead compounds for inflammation, four new (1-4) and six known (6-10) triterpenoids were acquired from Lantana camara. Using NMR and MS techniques and electronic circular dichroism (ECD) calculations, these isolates were characterized and the new compounds (1-4) were found to be euphane-type triterpenoids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bioorg.2020.104004DOI Listing

High spatial resolution analysis of polybrominated diphenyl ethers (PBDEs) using transplanted lichen Evernia prunastri: A case study in central Italy.

Sci Total Environ 2020 Jun 29;742:140590. Epub 2020 Jun 29.

Department of Public Health and Infectious Diseases, University of Rome La Sapienza, P.le Aldo Moro, 5, 00185 Rome, Italy. Electronic address:

The ability of transplanted lichen Evernia (E.) prunastri (L.) to act as a high spatial biomonitoring tool for 14 polybrominated diphenyl ethers (PBDEs) was evaluated at 23 monitoring sites in a very polluted area in central Italy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2020.140590DOI Listing

Assessment of acute toxicological effects of molybdenum(IV) disulfide nano- and microparticles after single intratracheal administration in rats.

Sci Total Environ 2020 Jun 27;742:140545. Epub 2020 Jun 27.

Nofer Institute of Occupational Medicine, Łódź, Poland. Electronic address:

Despite growing applications of molybdenum(IV) sulfide (MoS) nano- and microparticles in their capacity as lubricants, data available on their safety are scarce. In this study the effect of MoS nano- and microparticles after single intratracheal instillation in rats has been analyzed. MoS suspensions were administered at the dose of 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2020.140545DOI Listing

Can UV-C laser pulsed irradiation be used for the removal of organic micropollutants from water? Case study with ibuprofen.

Sci Total Environ 2020 Jun 29;742:140507. Epub 2020 Jun 29.

Instituto de Ciencia de Materiales de Aragón (CSIC-Universidad de Zaragoza), c/María de Luna 3, 50018 Zaragoza, Spain. Electronic address:

A novel approach based on the direct pulsed irradiation of UV-C light onto ibuprofen (IBP) solutions was evaluated in this work, as proof of concept for the direct removal of micropollutants. The experiments confirmed that laser irradiation is able to completely degrade IBP in 15 min in distilled water, with a DOC depletion of ca. 25% and with transformation products (TPs) remaining in solution and estimated to represent ca. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2020.140507DOI Listing

Naphthylisoquinoline alkaloids and their synthetic analogs as potent novel inhibitors against Babesia canis in vitro.

Vet Parasitol 2020 Jun 26;283:109177. Epub 2020 Jun 26.

Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, ul. Głęboka 30, 20-612, Lublin, Poland. Electronic address:

Babesia canis is the predominant and clinically relevant canine Babesia species in Europe. Transmitted by vector ticks, the parasite enters red blood cells and induces a severe, potentially fatal hemolytic anemia. Here, we report on the antibabesial activities of three extracts of the West African tropical plant species Triphyophyllum peltatum (Dioncophyllaceae) and Ancistrocladus abbreviatus (Ancistrocladaceae) and of 13 genuine naphthylisoquinoline alkaloids isolated thereof. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vetpar.2020.109177DOI Listing

Enlightening the advancements in electrochemical bioanalysis for the diagnosis of Alzheimer's disease and other neurodegenerative disorders.

J Pharm Biomed Anal 2020 Jun 21;189:113437. Epub 2020 Jun 21.

Department of Analytical Chemistry, Faculty of Chemical Sciences, Complutense University of Madrid, Madrid, 28040, Spain. Electronic address:

Neurodegenerative disorders (NDD), and particularly Alzheimer's disease (AD), are one of the greatest challenges facing our current medicine and society because of its increasing incidence and the high burden imposed both on patients' families and health systems. Despite this, their accurate diagnosis, mostly conducted by cerebrospinal fluid (CSF) analysis or neuroimaging techniques, costly, time-consuming, and unaffordable for most of the population, remains a complex task. In this situation, electrochemical biosensors are flourishing as promising alternative tools for the simple, fast, and low-cost diagnosis of NDD/AD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpba.2020.113437DOI Listing

Improvement of organisms by biomimetic mineralization: a material incorporation strategy for biological modification.

Acta Biomater 2020 Jul 3. Epub 2020 Jul 3.

Center for Biomaterials and Biopathways, Department of Chemistry, Zhejiang University, Hangzhou, 310027 China; Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, 310027 China. Electronic address:

Biomineralization, a bio-organism controlled mineral formation process, plays an important role in linking biological organisms and mineral materials in nature. Inspired by biomineralization, biomimetic mineralization is used as a bridge tool to integrate biological organisms and functional materials together, which can be beneficial for the development of diversified functional organism-material hybrids. In this review, recent progresses on the techniques of biomimetic mineralization for organism-material combinations are summarized and discussed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actbio.2020.06.038DOI Listing

The effect of chloride, sulfate and dissolved inorganic carbon on iron release from cast iron.

Water Res 2020 Jun 16;183:116037. Epub 2020 Jun 16.

School of Energy, Environmental, Biological & Medical Engineering, University of Cincinnati, 601 Engineering Research Center, Cincinnati, OH, 45221-0012.

Iron corrosion in drinking water distribution systems causes water discoloration, water quality deterioration, hydraulic loss, and even pipe failures, which are usually influenced by pipe scale structure, water hydraulics, water chemistry, and other factors. This work evaluated the effects of chloride, sulfate, and dissolved inorganic carbon (DIC) on iron release from a 90-year-old cast iron pipe section at water pH 8.0 under stagnant conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.watres.2020.116037DOI Listing

Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo.

J Control Release 2020 Jul 3. Epub 2020 Jul 3.

The University of Texas Southwestern Medical Center, Department of Biochemistry, Simmons Comprehensive Cancer Center, Dallas, TX 75390, United States. Electronic address:

mRNA-based therapeutics have emerged as a promising approach to treat cancer. However, creation of theranostic strategies to both deliver mRNA and simultaneously detect cancer is an important unmet goal. Here, we report the development of theranostic dendrimer-based lipid nanoparticle (DLNP) system containing PEGylated BODIPY dyes (PBD) for mRNA delivery and near-infrared (NIR) imaging in vitro and in vivo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2020.06.030DOI Listing

Host-guest complexes - boosting the performance of photosensitizers.

Int J Pharm 2020 Jul 3:119595. Epub 2020 Jul 3.

Institute of Organic Chemistry, University of Duisburg-Essen, Universitätsstrasse 2, 45141 Essen, Germany. Electronic address:

In this review, we will show the diversity of supramolecular host-guest complexes of cyclodextrins, cucurbit[n]urils, calix[n]- and pillar[n]arenes with photosensitizers, like porphyrins and phthalocyanines. Host-guest complexes are one of the main building blocks in supramolecular chemistry. For example, they have been widely used to encapsulate hydrophobic drug molecules to enhance the bioavailability in the human body. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2020.119595DOI Listing

Efficient production of bioactive structured lipids by fast acidolysis catalyzed by Yarrowia lipolytica lipase, free and immobilized in chitosan-alginate beads, in solvent-free medium.

Int J Biol Macromol 2020 Jul 3. Epub 2020 Jul 3.

Laboratory of Nutritional Biochemistry and Food Science, Institute of Chemistry, Federal University of Rio de Janeiro, Brazil. Electronic address:

Structured lipids (SL) represent a new generation of lipids, considered bioactive compounds. Medium-chain, oleic (18:1n-9), and medium-chain fatty acid (MCFA) structured lipids (MOM-SL) were produced by acidolysis reaction in solvent-free medium with capric (10:0) and lauric (12:0) free fatty acids (FFAs) and triolein or olive oil, using Yarrowia lipolytica lipase as biocatalyst. MCFAs were rapidly incorporated into sn-1,3 SL in acidolysis reactions with triolein and olive oil, up until 30% of incorporation efficiency of capric and lauric acids in SLs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2020.06.282DOI Listing

Xylanase immobilization onto trichlorotriazine-functionalized polyethylene glycol grafted magnetic nanoparticles: A thermostable and robust nanobiocatalyst for fruit juice clarification.

Int J Biol Macromol 2020 Jul 3. Epub 2020 Jul 3.

Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palacky University, Šlechtitelů 27, 783 71 Olomouc, Czech Republic.

The covalent immobilization of xylanase onto the trichlorotriazine-functionalized polyethylene glycol grafted magnetic nanoparticles was exploited to generate a stabilized xylanase with improved catalytic activity and stability. Several tools were deployed to monitor the synthesis and immobilization processes, the loading capacity of nanocarrier, and the structural/chemical characteristics of the nanobiocatalyst. The optimum immobilization yield of xylanase was 260 mg xylanase/g nanocarrier in 20 mM phosphate buffer, pH 6. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2020.06.273DOI Listing

Time-resolved fluorescence spectroscopy based evaluation of stability of glucose oxidase.

Int J Biol Macromol 2020 Jul 3. Epub 2020 Jul 3.

Department of Physical Chemistry, Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko Str. 24, LT-03225 Vilnius, Lithuania; Center for Physical Sciences and Technology, Sauletekio Av. 3, LT-10257 Vilnius, Lithuania. Electronic address:

Glucose oxidase (GOx) is one of the most frequently used enzymes in a design of enzymatic biosensors and biofuel cells, which are novel electrical energy generation systems. Therefore, a better understanding of the mode of action of this enzyme is very important for further development of GOx-based sensors. In this research fluorescence properties of GOx in different acidic media have been estimated by the evaluation of redox states of active center that is flavine adenine dinucleotide (FAD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2020.06.284DOI Listing

Development of sustainable magnetic chitosan biosorbent beads for kinetic remediation of arsenic contaminated water.

Int J Biol Macromol 2020 Jul 3. Epub 2020 Jul 3.

Department of Chemistry, University of Agriculture, Faisalabad 38000, Pakistan.

We report the preparation of both control chitosan and magnetic chitosan beads as biosorbents using chitosan as matrix and magnetite (FeO) nanoparticles as reinforcement followed by detailed advanced characterization. The batch trials were performed to study the adsorption kinetics of biosorbents by removing As and As species from water systems. The experimental data was inserted into Langmuir and Freundlich's isotherms to undertake the mechanism and adsorption capacity of the test biosorbents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2020.06.287DOI Listing

Enhanced production and immunomodulatory activity of levan from the acetic acid bacterium, Tanticharoenia sakaeratensis.

Int J Biol Macromol 2020 Jul 4. Epub 2020 Jul 4.

Department of Biochemistry and Research Unit of Natural Bioactive Compounds for Healthcare Products Development, Faculty of Science, Burapha University, Chonburi 20131, Thailand; Center of Excellence for Innovation in Chemistry, Burapha University, 20131, Thailand.

Levan is a fructose polymer with β-(2 → 6) glycosidic linkages. It is produced by several microorganisms, and due to its potential biotechnological and industrial applications, various levan-producing bacteria with different levels of production efficiencies have been reported. We investigated the levan-producing ability of the acetic acid bacterium, Tanticharoenia sakaeratensis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2020.07.001DOI Listing

Self-assembled DNA nanoparticles loaded with Travoprost for Glaucoma-treatment.

Nanomedicine 2020 Jul 3:102260. Epub 2020 Jul 3.

Department of Polymer Chemistry, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747, AG, Groningen, The Netherlands; DWI - Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, 52056, Aachen, Germany; Institute for Technical and Macromolecular Chemistry, RWTH Aachen University, Worringerweg 2, 52074, Aachen, Germany. Electronic address:

Lipid DNA nanoparticles (NPs) exhibit an intrinsic affinity to the ocular surface and can be loaded by hybridization with fluorophore-DNA conjugates or with the anti-glaucoma drug travoprost by hybridizing an aptamer that binds the medication. In the travoprost-loaded NPs (Trav-NPs), the drug is bound by specific, non-covalent interactions, not requiring any chemical modification of the active pharmaceutical ingredient. Fluorescently labeled Trav-NPs show a long-lasting adherence to the eye, up to sixty minutes after eye drop instillation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nano.2020.102260DOI Listing

Anti-amoebic potential of azole scaffolds and nanoparticles against pathogenic Acanthamoeba.

Acta Trop 2020 Jul 3:105618. Epub 2020 Jul 3.

Department of Biology, Chemistry and Environmental Sciences, College of Arts and Sciences, American University of Sharjah, Sharjah 26666, United Arab Emirates.

Acanthamoeba spp. are free living amoeba (FLA) which are widely distributed in nature. They are opportunistic parasites and can cause severe infections to the eye, skin and central nervous system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actatropica.2020.105618DOI Listing

Rh(III)-Catalyzed C(sp)-H Acetoxylation of 8-Methylquinolines.

Org Lett 2020 Jul 6. Epub 2020 Jul 6.

Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210023, China.

A mild and efficient Rh(III)-catalyzed aliphatic C-H acetoxylation directed by quinolines has been developed with widespread functional groups, including various halogens, which usually can provide precursors for further organic synthesis but easily results in selectivity issues in the Pd- and Ni-catalyzed reaction. Interestingly, AcO plays an essential role in promoting the transformation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.orglett.0c01715DOI Listing

Synthesis, Crystal Structure and Green Luminescence in Zero-Dimensional Tin Halide (CHN)SnBr.

Inorg Chem 2020 Jul 6. Epub 2020 Jul 6.

The State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques, School of Materials Science and Technology, South China University of Technology, Guangzhou, 510640, P. R. China.

Organic-inorganic hybrid metal halides with broad-band emission are currently receiving an increasing interest for their unique light emission properties. Here we report a novel lead-free zero-dimensional (0D) tin halide, (CHN)SnBr, in which isolated [SnBr] octahedrons are cocrystallized with organic cations, 1,3-bis(aminomethyl)benzene (CHN). Upon photoexcitation, the bulk crystals exhibit broad-band green emission peaking at 507 nm with a full width at half-maximum (fwhm) of 82 nm (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.inorgchem.0c01103DOI Listing

Perfluorocarbons in Chemical Biology.

Chembiochem 2020 Jul 6. Epub 2020 Jul 6.

UCLA, Chemistry and Biochemistry, 607 Charles E Young Dr, MSB 4505A, 90095, Los Angeles, UNITED STATES.

Perfluorocarbons, saturated carbon chains where all the hydrogen atoms are replaced with fluorine, form a separate phase from both organic and aqueous solutions. Though perfluorinated compounds are not found in living systems, they can be used to modify biomolecules to confer orthogonal behavior within natural systems, such as improved stability, engineered assembly, and cell-permeability. Perfluorinated groups also provide handles for purification, mass-spectrometry, and 19 F NMR studies in complex environments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.202000297DOI Listing

Symmetry Effects in Photoinduced Electron Transfer in Chlorin-Quinone Dyads: Adiabatic Suppression in the Marcus Inverted Region.

Chemistry 2020 Jul 6. Epub 2020 Jul 6.

Universitat Bremen, Institut für Organische und Analytische Chemie, GERMANY.

In donor acceptor dyads undergoing photoinduced electron transfer (PET), a direction or pathway for electron movement is usually dictated by the redox properties and the separation distance between the donor and acceptor subunits, while the effect of symmetry is less recognized. We have designed and synthesized two isomeric donor-acceptor assemblies in which electronic coupling between donor and acceptor is switched on/off by the orbital symmetry control with the reorganization energy and charge transfer exothermicity being kept unchanged. Analysis of the optical absorption and luminescence spectra, supported by the DFT and TD-DFT calculations, showed that PET in these assemblies corresponds to the Marcus inverted region (MIR) and has larger rate for isomer with weaker electronic coupling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/chem.202002736DOI Listing

Carrier Induced Modification of Palladium Nanoparticles on Porous Boron Nitride for Alkyne Semi-Hydrogenation.

Angew Chem Int Ed Engl 2020 Jul 6. Epub 2020 Jul 6.

ETH Zurich, Institute for Chemical and Bioengineering, ETH Hönggerberg, Vladimir-Prelog-Weg 1, HCI E125, CH-8093, Zurich, SWITZERLAND.

Chemical modifiers enhance the efficiency of metal catalysts in numerous applications, but their introduction often involves toxic or expensive precursors and complicates the synthesis. Here, we show that a porous boron nitride carrier can directly modify supported palladium nanoparticles, originating unparalleled performance in the continuous semi-hydrogenation of alkynes. Analysis of the impact of various structural parameters reveals that using a defective high surface area boron nitride and ensuring a palladium particle size of 4-5 nm is critical to maximizing the specific rate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.202005842DOI Listing

One-pot synthesis of chiral N-arylamines by combining biocatalytic aminations with Buchwald-Hartwig N-arylation.

Angew Chem Int Ed Engl 2020 Jul 6. Epub 2020 Jul 6.

University of Manchester, Chemistry, Manchester Institute of Biotechnology, 131 Princess Street, M1 7DN, Manchester, UNITED KINGDOM.

The combination of biocatalysis and chemo-catalysis increasingly offers chemists access to more diverse chemical architectures. Here, we describe the combination of a toolbox of chiral amine producing biocatalysts with a Buchwald-Hartwig cross-coupling reaction, affording a variety of a-chiral aniline derivatives. The use of a surfactant allowed reactions to be performed sequentially in the same flask, preventing the palladium catalyst being inhibited by the high concentrations of ammonia, salts or buffers present in the aqueous media in most cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.202006246DOI Listing

Enantioselective Synthesis of Cyclopropanone Equivalents and Application to the Formation of Chiral β-Lactams.

Angew Chem Int Ed Engl 2020 Jul 6. Epub 2020 Jul 6.

North Carolina State University, Chemistry, 2620 Yarbrough Drive, 27695, Raleigh, UNITED STATES.

Cyclopropanone derivatives have long been considered unsustainable synthetic intermediates due to their extreme strain and kinetic instability. Herein, we report the enantioselective synthesis of 1-sulfonylcyclopropanols as stable yet powerful equivalents of the corresponding cyclopropanone derivatives, via α-hydroxylation of sulfonylcyclopropanes using a bis(silyl) peroxide as electrophilic oxygen source. This work constitutes the first general approach to enantioenriched cyclopropanone derivatives. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.202006786DOI Listing

Photodynamic inactivation of the phytopathogenic bacterium Xanthomonas citri subsp. citri.

Lett Appl Microbiol 2020 Jul 6. Epub 2020 Jul 6.

CESAM and Department of Biology, University of Aveiro, Campus de Santiago, 3810-193, Aveiro, Portugal.

The present work intended to evaluate the applicability of photodynamic inactivation (PDI) of Xanthomonas citri subsp. citri with toluidine blue O (TBO), a commercial photosensitizer, as a strategy to control citrus canker. Assays were conducted with cell suspensions and biofilms, constructed either on polypropylene microtubes (in vitro assays) or on the surface of orange leaves (ex vivo assays), in the presence of TBO and under irradiation with artificial white light or natural sunlight. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/lam.13350DOI Listing

Comprehensive two-dimensional liquid chromatography-based quali-quantitative screening of aqueous phases from pyrolysis bio-oils.

Electrophoresis 2020 Jul 6. Epub 2020 Jul 6.

Laboratory of Foodomics, Institute of Food Science Research (CIAL, CSIC-UAM), Nicolás Cabrera 9, Madrid, Spain, 28049.

Pyrolysis processes are an alternative to minimize the environmental problem associated to agri-food industrial wastes. The main product resulting from these processes is a high-value liquid product, called bio-oil. Recently, the use of comprehensive two-dimensional liquid chromatography (LC × LC) has been demonstrated as a useful tool to improve the characterization of the water-soluble phases of bio-oils, considering their complexity and high water content. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/elps.202000119DOI Listing

From Skepticism to Embrace: The Role of Targeted Mass Spectrometry in Validating Proteomics.

Clin Chem 2020 Jul;66(7):973-974

Proteomics Group, Broad Institute of MIT and Harvard, Cambridge, MA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/clinchem/hvaa111DOI Listing

Behavioral responses of Diaphorina citri to host plant volatiles in multiple-choice olfactometers are affected in interpretable ways by effects of background colors and airflows.

PLoS One 2020 6;15(7):e0235630. Epub 2020 Jul 6.

Department of Research and Development, Fund for Citrus Protection (Fundecitrus), Araraquara, São Paulo, Brazil.

In several phytophagous hemipterans, behavior appears to be mediated by both visual and chemical cues. For the Asian citrus psyllid (ACP) Diaphorina citri (Hemiptera: Liviidae), olfactometric assays are generally difficult to interpret owing to the low proportion of individuals responding to odors (~30-40%), which compromises the efficiency and reliability of the results of behavioral tests. In the present study, the ACP behavioral response to emitted odors from sweet orange (Citrus sinensis L. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235630PLOS
  • Page 1 of 92546