4,289,218 results match your criteria Chemistry Weinheim an der Bergstrasse Germany[Journal]


Soil organic carbon stability in forests: distinct effects of tree species identity and traits.

Glob Chang Biol 2018 Dec 16. Epub 2018 Dec 16.

Chair of Soil Science, Technical University Munich (TUM), Emil-Ramann-Str. 2, D-85354, Freising, Germany.

Rising atmospheric CO concentrations have increased interest in the potential for forest ecosystems and soils to act as carbon (C) sinks. While soil organic C contents often vary with tree species identity, little is known about if, and how, tree species influence the stability of C in soil. Using a 40-year-old common garden experiment with replicated plots of eleven temperate tree species, we investigated relationships between soil organic matter (SOM) stability in mineral soils and 17 ecological factors (including tree tissue chemistry, magnitude of organic matter inputs and their turnover, microbial community descriptors, and soil physico-chemical properties). Read More

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December 2018

Advances in understanding obligate biotrophy in rust fungi.

New Phytol 2018 Dec 16. Epub 2018 Dec 16.

UMR 1136 INRA/Université de Lorraine Interactions Arbres/Microorganismes, INRA Centre Grand Est - Nancy, 54280, Champenoux, France.

Rust fungi (Pucciniales) are the largest group of plant pathogens and represent one of the most devastating threats to agricultural crops worldwide. Despite the economic importance of these highly specialized pathogens, many aspects of their biology remain obscure largely because rust fungi are obligate biotrophs. The rise of genomics and advances in high-throughput sequencing technology have presented new options for identifying candidate effector genes involved in pathogenicity mechanisms of rust fungi. Read More

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December 2018

Daily oral cyanocobalamin supplementation in Beagles with hereditary cobalamin malabsorption (Imerslund-Gräsbeck syndrome) maintains normal clinical and cellular cobalamin status.

J Vet Intern Med 2018 Dec 15. Epub 2018 Dec 15.

Department of Clinical Chemistry, University Children's Hospital Zurich, Zurich, Switzerland.

Background: Efficacy of PO cobalamin (Cbl) supplementation in dogs with hereditary Cbl malabsorption (Imerslund-Gräsbeck syndrome, IGS) is unknown.

Objectives: To evaluate PO Cbl supplementation in Beagles with IGS previously treated parenterally. We hypothesized that 1 mg cyano-Cbl daily PO would maintain clinical and metabolic remission. Read More

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December 2018
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Salivary Nickel and Chromium Levels in Orthodontic Patients with and Without Periodontitis: a Preliminary Historical Cohort Study.

Biol Trace Elem Res 2018 Dec 15. Epub 2018 Dec 15.

Pharmaceutical Chemistry, North Branch, Islamic Azad University, Tehran, Iran.

Many periodontal patients may need orthodontic treatment. Alterations in oral environment particularly the reduction of pH in periodontal patients could affect metal ion release from orthodontic appliances. However, there is no study on metal ion release in periodontal patients. Read More

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December 2018

Differential Susceptibility of Wild and Cultivated Blueberries to an Invasive Frugivorous Pest.

J Chem Ecol 2018 Dec 15. Epub 2018 Dec 15.

Laboratory of Evolutionary Entomology, Institute of Biology, University of Neuchâtel, Emile Argand 11, Case postale 158, 2009, Neuchâtel, Switzerland.

Highbush blueberry is a crop native to the northeast USA that has been domesticated for about 100 years. This study compared the susceptibility of wild and domesticated/cultivated highbush blueberries to an invasive frugivorous pest, the spotted wing drosophila (Drosophila suzukii). We hypothesized that: 1) cultivated fruits are preferred by D. Read More

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December 2018

Voltammetric determination of levofloxacin using silver nanoparticles deposited on a thin nickel oxide porous film.

Mikrochim Acta 2018 Dec 15;186(1):21. Epub 2018 Dec 15.

School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, People's Republic of China.

The authors describe a simplified chemical precipitation method and silver mirror reaction to synthesize a nanocomposite consiting of silver nanoparticles on a thin and porous nickel oxide film. Placed on a glassy carbon electrode (GCE), it allows for the determination of levofloxacin (LEV) via square wave voltammetry (SWV). Under optimal detection conditions, the voltammetric signal (typically measured at around 0. Read More

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December 2018

Novel flourescent spiroborate esters: potential therapeutic agents in in vitro cancer models.

Mol Biol Rep 2018 Dec 15. Epub 2018 Dec 15.

Department of Biochemistry, University of Kerala, Thiruvananthapuram, Kerala, India.

The current treatment system in cancer therapy, which includes chemotherapy/radiotherapy is expensive and often deleterious to surrounding healthy tissue. Presently, several medicinal plants and their constituents are in use to manage the development and progression of these diseases.They have been found effective, safe, and less expensive. Read More

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December 2018
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Molecular and NLO Properties of Red Fluorescent Coumarins - DFT Computations Using Long-Range Separated and Conventional Functionals.

J Fluoresc 2018 Dec 15. Epub 2018 Dec 15.

Computational Chemistry Group, Department of Chemistry, Faculty of Science, University of Mauritius, Réduit, 80832, Mauritius.

Comparative study of nonlinear optical properties of red fluorescent coumarins was carried out with density functional theory based ab initio method using the popular global hybrid (GH) and range separated hybrid (RSH) functionals and correlated with the spectroscopic values. The GHs - M06 L, PBE1PBE, M06, BHHLYP, M062X and M06HF and RSHs - HISSbPBE, wB97, wB97X, HSEH1PBE, CAM-B3LYP and wB97XD in combination with the double zeta basis function 6-311 + G(d,p) were used. The computed polarizability (α), hyperpolarizability of the first order (β) and second order (γ) computed by the RSHs are closer to the spectroscopic values compared to GHs. Read More

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December 2018

Comparative analysis of intracellular metabolites, proteins and their molecular functions in a flor yeast strain under two enological conditions.

World J Microbiol Biotechnol 2018 Dec 15;35(1). Epub 2018 Dec 15.

Department of Microbiology, Severo Ochoa (C6) building, Agrifood Campus of International Excellence ceiA3, University of Córdoba, Córdoba, Spain.

Flor yeasts confer a wide range of organoleptic properties to Sherry-type wines during a process called "biological aging" that takes place after alcoholic fermentation. These kinds of yeasts adapt to a biological aging condition by forming a biofilm known as "flor velum" and by changing from fermentative to oxidative metabolism. It has been reported that some functions such as increase of cell surface hydrophobicity or changes to lipid metabolism are enhanced when yeasts switch to biofilm lifestyle. Read More

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December 2018

A step towards development of promising trypanocidal agents: Synthesis, characterization and in vitro biological evaluation of ferrocenyl Mannich base-type derivatives.

Eur J Med Chem 2018 Dec 4;163:569-582. Epub 2018 Dec 4.

Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale, Viale T. Michel 11, 15121, Alessandria, Italy. Electronic address:

Chagas disease is a neglected chronical parasitosis caused by the parasite Trypanosoma cruzi (T. cruzi). Nine ferrocenyl Mannich base derivatives were synthetized and characterized to explore their in vitro activity on three T. Read More

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December 2018

Therapeutic targeting of angiogenesis molecular pathways in angiogenesis-dependent diseases.

Biomed Pharmacother 2018 Dec 13;110:775-785. Epub 2018 Dec 13.

Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Molecular Medicine Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Angiogenesis is a critical step in the progression of almost all human malignancies and some other life-threatening diseases. Anti-angiogenic therapy is a novel and effective approach for treatment of angiogenesis-dependent diseases such as cancer, diabetic retinopathy, and age-related macular degeneration. In this article, we will review the main strategies developed for anti-angiogenic therapies beside their clinical applications, the major challenges, and the latest advances in the development of anti-angiogenesis-based targeted therapies. Read More

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December 2018

Simultaneous detection of three biomarkers related to acute myocardial infarction based on immunosensing biochip.

Biosens Bioelectron 2018 Dec 6;126:767-772. Epub 2018 Dec 6.

Jiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China. Electronic address:

An immunosensing biochip for simultaneous detection of three biomarkers related to acute myocardial infarction (AMI) was developed based on anionic soybean peroxidase (SBP) functionalized nanoprobe and chemiluminescent imaging. The nanoprobes (Ab2-SiO-SBP) were fabricated by co-immobilization of SBP and one of the detection polyclonal antibodies, anti-cardiac troponin I antigen (anti-cTnI), anti-creatine kinase-MB (anti-CK-MB) and anti-myoglobin (anti-Myo), on the silica nanoparticle surface. The detection sensitivity was enhanced since the large surface area of silica carriers increased the loading of SBP for per sandwiched immunoreaction. Read More

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December 2018

Simultaneous detection of ATP metabolites in human plasma and urine based on palladium nanoparticle and poly(bromocresol green) composite sensor.

Biosens Bioelectron 2018 Dec 8;126:758-766. Epub 2018 Dec 8.

Department of Chemistry and Institute of BioPhysio Sensor Technology (IBST), Pusan National University, Busan 46241, Republic of Korea. Electronic address:

A sensitive voltammetric sensor based on palladium nanoparticles (PdNPs) and poly-bromocresol green (pBG) composite layer immobilized on amide functionalized single-walled carbon nanotubes (AmSWCNTs) modified pyrolytic graphite (PdNPs:pBG/AmSWCNTs/PG) has been prepared for the simultaneous determination of adenosine triphosphate (ATP) catabolites, inosine (INO), hypoxanthine (HX), xanthine (XT), and uric acid (UA). The modified PdNPs:pBG/AmSWCNTs/PG was characterized by electrochemical experiments and surface analysis, which exhibited exceptional electrocatalytic effects towards the oxidation of INO, HX, XT, and UA with a significant enhanced peak current and well resolved peaks separation for all the analytes. The linear calibration curves were obtained in the concentration range of 0. Read More

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December 2018

Intercellular adhesion molecule 1 antibody-mediated mesoporous drug delivery system for targeted treatment of triple-negative breast cancer.

J Colloid Interface Sci 2018 Dec 10;538:630-637. Epub 2018 Dec 10.

Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, 210002 Jiangsu, PR China; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093 Jiangsu, PR China; Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210046 Jiangsu, PR China. Electronic address:

The development of effective targeted therapies for triple negative breast cancer (TNBC) remains a challenge. This targeted drug delivery system used a near-infrared fluorescence dye cyanine 5.5 (Cy5. Read More

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December 2018

A general strategy to fabricate soft magnetic CuFeO@SiO nanofibrous membranes as efficient and recyclable Fenton-like catalysts.

J Colloid Interface Sci 2018 Dec 8;538:620-629. Epub 2018 Dec 8.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China; Key Laboratory of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China; Innovation Center for Textile Science and Technology, Donghua University, Shanghai 200051, China. Electronic address:

Fenton or Fenton-like technique, as one of the advanced oxidation processes, plays a significant role in the removal of non-easily degradable organic pollutants; however, most of such catalysts are fragile with poor structural integrity under large deformation, thereby restricting their wide applications. Herein, soft copper ferrite nanostructures functionalized silica nanofibrous membranes (CuFeO@SNM) were fabricated through a novel strategy with the combination of in-situ dopamine polymerization, ion adsorption, and cohesive precipitation method. Benefiting from the high metallic ion adsorption capacity of polydopamine together with the rapid co-precipitation of adsorbed ions on fiber surface in alkaline solution, the membranes possessed homogenously distributed nanostructured CuFeO, large specific surface area, and high pore volume, which are a benefit for the improvement of Fenton-like catalytic activity towards organic pollutants decomposition. Read More

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December 2018

N-Alkyl-1,5-dideoxy-1,5-imino-l-fucitols as fucosidase inhibitors: Synthesis, molecular modelling and activity against cancer cell lines.

Bioorg Chem 2018 Dec 4;84:418-433. Epub 2018 Dec 4.

School of Chemistry, National University of Ireland Galway, University Road, Galway H91 TK33, Ireland. Electronic address:

1,5-Dideoxy-1,5-imino-l-fucitol (1-deoxyfuconojirimycin, DFJ) is an iminosugar that inhibits fucosidases. Herein, N-alkyl DFJs have been synthesised and tested against the α-fucosidases of T. maritima (bacterial origin) and B. Read More

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December 2018

Non canonical genetic material.

Curr Opin Biotechnol 2018 Dec 13;57:25-33. Epub 2018 Dec 13.

KU Leuven, Rega Institute for Medical Research, Medicinal Chemistry, Herestraat 49, 3000 Leuven, Belgium. Electronic address:

To increase the scope of natural biosystem, nucleic acids have been intensively modified. One direction includes the development of a synthetic alternative to the native DNA and RNA, denoted Xenobiotic nucleic acids (XNAs) that are able to store and transfer genetic information either by base-modification or backbone-modification. Another line of research aims to develop alternative third base pair additional to natural A:T and G:C. Read More

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December 2018

Nucleotide conjugated (ZnO) cluster: Interaction and optical characteristics using TDDFT.

J Mol Graph Model 2018 Dec 7;87:211-219. Epub 2018 Dec 7.

Theoretical & Computational Chemistry Group, Department of Chemistry, Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh, 160014, India. Electronic address:

Binding of four DNA nucleotide units with (ZnO) cluster in an aqueous phase has been investigated using density functional theory (DFT) and time dependent-density functional theory (TDDFT) method and the stability order for (ZnO)-nucleobases/sugar/phosphate systems is predicted as phosphate > C > A > S > T ∼ G. The order of binding energy for (ZnO)-nucleotide hybrid systems is observed to be (ZnO) + nuc-C ˃ (ZnO) + nuc-A ˃ (ZnO) + nuc-G ˃ (ZnO) + nuc-T. The binding of nucleotide units with the cluster has been explained on the basis of molecular electrostatic potential (MEP) plots, hydrogen bonding, glycosidic torsion angles, density of state (DOS) plots. Read More

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December 2018

Inhibition mechanism of L,D-transpeptidase 5 in presence of the β-lactams using ONIOM method.

J Mol Graph Model 2018 Nov 28;87:204-210. Epub 2018 Nov 28.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa. Electronic address:

Tuberculosis (TB) is one of the world's deadliest diseases resulting from infection by the bacterium, Mycobacterium tuberculosis (M.tb). The L,D-transpeptidase enzymes catalyze the synthesis of 3 → 3 transpeptide linkages which are predominant in the peptidoglycan of the M. Read More

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November 2018

Seasonal changes in amino acids and phenolic compounds in fruits from hybrid cross populations of American grapes differing in disease resistance.

Plant Physiol Biochem 2018 Dec 3;135:182-193. Epub 2018 Dec 3.

Plant Biology and Horticulture Sections, School of Integrative Plant Science, Cornell University, Ithaca, NY, 14853, USA. Electronic address:

The production of wine grapes in upstate New York (USA) is limited by diseases that are promoted by the cool and sometimes rainy climate. A breeding program has been introducing disease resistance from related species into the cultivated stock. Previous work has indicated that such resistance may be based on biochemical reactions rather than on a hypersensitive reaction. Read More

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December 2018

Distribution of antibiotic resistance genes in soils and crops. A field study in legume plants (Vicia faba L.) grown under different watering regimes.

Environ Res 2018 Dec 6;170:16-25. Epub 2018 Dec 6.

Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research, 08034 Barcelona, Spain. Electronic address:

Social concern has raised during the last years due to the development of antibiotic resistance hotspots in different environmental compartments, including the edible parts of crops. To assess the influence of the water quality used for watering, we collected samples from soil, roots, leaves and beans from the legume plant Vicia faba (broad beans) in three agricultural peri-urban plots (Barcelona, NE Spain), irrigated with either groundwater, river water, or reclaimed water. Antibiotic resistance genes (ARGs) sul1, tetM, qnrS1, blabla, mecA, and bla were quantified by real-time PCR, along with 16S rDNA and intl1 sequences, as proxies for bacterial abundance and integron prevalence, respectively. Read More

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December 2018

Engineered nanomaterials inhibit Podosphaera pannosa infection on rose leaves by regulating phytohormones.

Environ Res 2018 Dec 6;170:1-6. Epub 2018 Dec 6.

Stockbridge School of Agriculture, University of Massachusetts Amherst, Amherst, MA 01003, United States.

In the present study, we investigated the antifungal effects of engineered nanomaterials (ENMs) against Podosphaera pannosa (P. pannosa), a fungal pathogen that causes powdery mildew on plants in the rose family. Four commercial ENMs, including multi-wall carbon nanotubes (MWCNTs), reduced graphene oxide (rGO), copper oxide (CuO) nanoparticles (NPs) and titanium dioxide (TiO) NPs, were used to prepare 50 or 200 mg/L NP suspensions in deionized water. Read More

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December 2018

Recent advances in metalloporphyrins for environmental and energy applications.

Chemosphere 2018 Dec 4;219:617-635. Epub 2018 Dec 4.

School of Environmental Science and Engineering, Huazhong University of Science and Technology (HUST), Wuhan, Hubei, 430074, PR China; Hubei Provincial Engineering Laboratory of Solid Waste Treatment, Disposal and Recycling, Huazhong University of Science and Technology (HUST), Wuhan, Hubei, 430074, PR China. Electronic address:

Porphyrin-based chemistry has reached an unprecedented period of rapid development after decades of study. Due to attractive multifunctional properties, porphyrins and their analogues have emerged as multifunctional organometals for environmental and energy purposes. In particular, pioneer works have been conducted to explore their application in pollution abatement, energy conversion and storage and molecule recognition. Read More

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December 2018

Uranium distribution in groundwater and assessment of age dependent radiation dose in Amritsar, Gurdaspur and Pathankot districts of Punjab, India.

Chemosphere 2018 Dec 7;219:607-616. Epub 2018 Dec 7.

Department of Physics, Guru Nanak Dev University, Amritsar, Punjab, 143005, India. Electronic address:

A comprehensive study of seasonal variation of uranium distribution in groundwater of Amritsar, Gurdaspur and Pathankot districts of Punjab, India and assessment of associated radiological risks, chemical risks and effective radiation dose for different age groups, was conducted to determine its health impact on humans residing in these regions. Physicochemical parameters such as pH, EC, TDS, total hardness and contents of various anions such as carbonates/bicarbonates, chlorides, fluorides, nitrates, sulphates and phosphates in groundwater were also analysed to determine correlation between groundwater chemistry and uranium distribution. The average values of uranium concentration in ground water samples of Amritsar, Gurdaspur and Pathankot districts were found to be 8. Read More

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December 2018

Influence of cell adhesive molecules attached onto PEG-lipid-modified fluid surfaces on cell adhesion.

Colloids Surf B Biointerfaces 2018 Dec 7;175:375-383. Epub 2018 Dec 7.

Department of Bioengineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan; Department of Immunology, Genetics and Pathology (IGP), Uppsala University, Dag Hammarskjölds väg 20, SE-751 85, Uppsala, Sweden. Electronic address:

The involvement of intercellular interactions in various biological events indicates the importance of studying cell-cell interactions using fluid model surfaces. Here, we propose a fluid surface composed of a self-assembled monolayer (SAM) and poly(ethylene glycol)-conjugated phospholipid (PEG-lipid) derivatives, which can be an alternative to supported lipid membranes. The modification of SAM surfaces with PEG-lipids carrying functional peptides resulted in the formation of the fluid surfaces with different mobility, which was quantitatively determined by quartz crystal microbalance with dissipation (QCM-D) and fluorescence recovery after photobleaching (FRAP). Read More

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December 2018

In-situ forming gels containing fluorometholone-loaded polymeric nanoparticles for ocular inflammatory conditions.

Colloids Surf B Biointerfaces 2018 Nov 27;175:365-374. Epub 2018 Nov 27.

Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain; Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Barcelona, Spain. Electronic address:

Thermosensitive gels have been developed and optimized in such a way that they become gels at corneal temperature and with a viscosity that allows the adequate release of the Fluorometholone (FMT)-loaded PLGA nanoparticles (NPs) in order to improve ocular anti-inflammatory efficacy against a commercial formulation. It has been shown that gels avoid burst release of the drug in the first hours with a slow and increasing profile after administration. NPs have maintained their average size and spherical shape within the gels as confirmed by transmission electron microscopy (TEM). Read More

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November 2018

Self-assembling and biological properties of single-chain dicationic pyridinium-based surfactants.

Colloids Surf B Biointerfaces 2018 Dec 6;175:351-357. Epub 2018 Dec 6.

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., Kazan, 420088, Russia; Kazan National Research Technological University, 68 K. Marks str., Kazan, 420015, Russia.

In this work, the dicationic surfactants containing viologen and vinylbipyridinium moieties and hexadecyl chains were synthesized, and their aggregation behavior in water solutions was investigated by surface tension, conductivity measurements, hydrophobic probe solubilization, dynamic light scattering and electrophoretic measurements. Effect of UV-light on cis-trans isomerism of vinylbipyridinium derivative was determined. Antimicrobial activity and the influence of these surfactants on cell viability depended on the concentration and type of surfactant used. Read More

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December 2018

Efficient capture of eosin yellow and crystal violet with high performance xanthan-acacia hybrid super-adsorbent optimized using response surface methodology.

Colloids Surf B Biointerfaces 2018 Dec 10;175:314-323. Epub 2018 Dec 10.

Department of Chemistry, Ambedkar National Institute of Technology, Jalandhar, Punjab, India.

Blending of xanthan and acacia gives a unique hybrid that was used for the synthesis of semi-interpenetrating network (semi-IPN) in which poly(acrylamide) chains were grafted onto hybrid of xanthan-acacia followed by their cross-linking (Xan-Aca-cl-poly(AAm)). Optimization was carried out under response surface methodology-central composite design (RSM-CCD). Maximum percentage swelling of semi-IPN obtained was 496. Read More

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December 2018

Phospholipase A2 products predict the hematopoietic support capacity of horse serum.

Differentiation 2018 Dec 6;105:27-32. Epub 2018 Dec 6.

Department of Hematology and Oncology, Medical Faculty, University of Leipzig, Leipzig, Germany.

Horse serum is commonly used as an additive to support the maintenance of hematopoietic progenitor cells in culture. However, the wide variability in the performance of different lots calls for parallel testing of multiple batches over extended periods of culture. Identification of the serum components that determine hematopoietic support would therefore save considerable time and effort and would help to standardize culture procedures. Read More

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December 2018

Recent preparative applications of redox enzymes.

Curr Opin Chem Biol 2018 Dec 12;49:105-112. Epub 2018 Dec 12.

Merck & Co., Inc., Rahway, NJ, 07065, USA. Electronic address:

Redox enzymes offer many powerful transformations for the efficient industrial-scale synthesis of diverse chemicals desired by society. Here we survey recent preparative applications of redox enzymes, highlighting both mature enzyme platforms and promising technologies for future applications. While in some cases commercial enzymes can be employed directly on industrial scales, in other cases protein engineering is necessary to evolve an enzyme fit for non-biological substrates and conditions. Read More

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December 2018

Selective detection of fluoride via amplified donor-acceptor interaction of 6H-indolo[2,3-b]quinoline.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Dec 4;211:246-253. Epub 2018 Dec 4.

Department of Chemical Sciences, Tezpur University, Assam 784028, India. Electronic address:

In this report, 6H-indolo[2,3-b]quinoline (hereafter 2a) was synthesized and employed as an optical chemosensor for fluoride. The sensitivity of 2a towards fluoride was established from the change in both the absorption and emission signals. The various in-situH NMR, UV-Vis, and density functional studies indicate that the 1:2 binding interaction between 2a and fluoride followed by deprotonation to its corresponding di-anion (2a), which in turn boosted the donor-acceptor interaction between indole and quinoline moiety in 2avia expansion of torsion angle by 10. Read More

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December 2018

Lipidomic analysis reveals the efficiency of Eclipta prostrata on diet-induced nonalcoholic fatty liver disease in rats.

J Pharm Biomed Anal 2018 Nov 30;165:224-232. Epub 2018 Nov 30.

Department of Therapeutic Chemistry, National Research Centre, Cairo, Egypt.

Non-alcoholic fatty liver disease is a leading cause of chronic liver disease in western countries. The current study aimed to detect and evaluate lipidomic biomarkers for early detection of NAFLD as well as the potential efficiency of methanolic extract of Eclipta prostrata (E. prostrata) on disease management. Read More

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November 2018

The response of maize protoplasts to cadmium stress mitigated by silicon.

Ecotoxicol Environ Saf 2018 Dec 13;170:488-494. Epub 2018 Dec 13.

Department of Glycobiotechnology, Institute of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, 845 38 Bratislava, Slovakia.

The aim of this article was to evaluate the viability of maize protoplasts, cell wall regeneration, Cd uptake by protoplasts, and the impact of silicon under cadmium cations (Cd) stress in two maize hybrids with contrasting tolerances to Cd toxicity. The differences in protoplast viability between the sensitive (Novania) and tolerant (Almansa) hybrids were noticeable even at the beginning of culture. The percentage of living protoplasts in the presence of Cd was higher in the tolerant hybrid. Read More

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December 2018

The concentration of dissolved organic matter impacts the metabolic response in Daphnia magna exposed to 17α-ethynylestradiol and perfluorooctane sulfonate.

Ecotoxicol Environ Saf 2018 Dec 13;170:468-478. Epub 2018 Dec 13.

Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, Canada M5S 3H6; Environmental NMR Centre and Department of Physical and Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON, Canada M1C 1A4. Electronic address:

The pharmaceutical 17α-ethynylestradiol (EE2) and the industrial chemical perfluorooctane sulfonate (PFOS) are organic contaminants frequently detected in freshwater environments. It is hypothesized that hydrophobic organic contaminants can sorb to dissolved organic matter (DOM) and this may reduce the toxicity of these contaminants by reducing the contaminants' bioavailability. To investigate this hypothesis, H nuclear magnetic resonance (NMR)-based metabolomics was used to determine how the metabolome of Daphnia magna changes when a range of DOM concentrations are added during EE2 and PFOS exposure experiments. Read More

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December 2018

Biodegradation of Cibacron Blue 3GA by insolubilized laccase and identification of enzymatic byproduct using MALDI-ToF-MS: Toxicity assessment studies by Daphnia magna and Chlorella vulgaris.

Ecotoxicol Environ Saf 2018 Dec 13;170:453-460. Epub 2018 Dec 13.

Biochemical Processing and Biomaterial Research Laboratory, Gazi University, 06500 Teknikokullar, Ankara, Turkey.

The presented paper describes a detailed study on the use of immobilized laccase for effective degradation of Cibacron Blue 3GA dye. The amount of laccase loading on the cyclic carbonate groups containing poly(hydroxyethyl methacrylate-co-vinylene carbonate), p(HEMA-co-VC), microbeads was 27.8 mg g, and the retained immobilized enzyme activity was 73% compared to free enzyme. Read More

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December 2018

A novel computational solution to the health risk assessment of air pollution via joint toxicity prediction: A case study on selected PAH binary mixtures in particulate matters.

Ecotoxicol Environ Saf 2018 Dec 13;170:427-435. Epub 2018 Dec 13.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100190, PR China; Institute of Environment and Health, Jianghan University, Wuhan 430056, PR China. Electronic address:

Regional haze episode has already caused overwhelming public concern. Unraveling the health effects of the representative composition mixtures of atmospheric fine particulate matters (PM) becomes a top priority. In this study, a novel computational solution integrating chemical-induced genomic residual effect prediction with in vitro-based risk assessment is proposed to obtain the cumulative health risk of typical chemical mixtures of particulate matters (PM). Read More

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December 2018

"In Fimo": A Term Proposed for Excrement Examined Experimentally.

Gastroenterology 2018 Dec 13. Epub 2018 Dec 13.

Departments of Chemistry, Microbiology and Immunology, and the Integrative Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599. Electronic address:

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December 2018

Effect of dietary supplementation with apple cider vinegar and propionic acid on hemolymph chemistry, intestinal microbiota and histological structure of hepatopancreas in white shrimp, Litopenaeus vannamei.

Fish Shellfish Immunol 2018 Dec 13. Epub 2018 Dec 13.

Iranian Fisheries Science Research Institute. Persian Gulf and Oman Sea Ecology Research Center, Persian Gulf Mollusks Research Station, Bandar-e- Lengeh, Iran.

This experiment was conducted to evaluate the effects of dietary supplementation of Apple cider vinegar (ACV) and propionic acid (PA) on biochemical parameters of hemolymph, intestinal microbiota and histology of hepatopancreas in white shrimp (Litopenaeus vannamei). Five experimental diets were evaluated in this study including diets supplemented with 1.0, 2. Read More

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December 2018

Human α-casein induces IL-8 secretion by binding to the ecto-domain of the TLR4/MD2 receptor complex.

Biochim Biophys Acta Gen Subj 2018 Dec 13. Epub 2018 Dec 13.

Institute of Pharmaceutical and Medicinal Chemistry, PharmaCampus, Westphalian Wilhelms-University, Corrensstr. 48, 48149 Münster, Germany. Electronic address:

Background: The milk protein α-casein was recently reported to induce secretion of proinflammatory cytokines via Toll-like receptor 4 (TLR4). In this study, α-casein was identified as binder of theTLR4 ecto domain.

Methods: IL-8 secretion after stimulation of TLR4/MD2 (myeloid differentiation factor 2)/CD14 (cluster of differentiation 14)-transfected HEK293 cells (TLR4) and Mono Mac 6 cells (MM6) with recombinant α-casein, or LPS as control was monitored. Read More

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December 2018

Current state of the polymeric delivery systems of fluoroquinolones - A review.

J Control Release 2018 Dec 13. Epub 2018 Dec 13.

Department of Biomaterials Chemistry, Chair of Analytical Chemistry and Biomaterials, Faculty of Pharmacy With the Laboratory Medicine Division, Medical University of Warsaw, 1 Banacha St., Warsaw 02-097, Poland. Electronic address:

Recently, growing interest in polymers (natural and synthetic) as drug carriers in controlled release formulations and drug targeting systems that may improve the efficacy of treatment and reduce the side effects of a drug therapy, has been observed. Special attention has been paid to improving the effectiveness of antibiotics, which constitute a very important, often life-saving group of drugs. In this paper, we review polymers as macromolecular carriers of fluoroquinolones, a group of antibiotics with a broad spectrum of activity. Read More

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December 2018

Uridine adenosine tetraphosphate and purinergic signaling in cardiovascular system: an update.

Pharmacol Res 2018 Dec 13. Epub 2018 Dec 13.

Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands.

Uridine adenosine tetraphosphate (UpA), biosynthesized by activation of vascular endothelial growth factor receptor (VEGFR) 2, was initially identified as a potent endothelium-derived vasoconstrictor in perfused rat kidney. Subsequently, the effect of UpA on vascular tone regulation was intensively investigated in arteries isolated from different vascular beds in rodents including rat pulmonary arteries, aortas, mesenteric and renal arteries as well as mouse aortas, in which UpA produces vascular contraction. In contrast, UpA produces vascular relaxation in porcine coronary small arteries and rat aortas. Read More

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December 2018

Corneal-PAMPA: A novel, non-cell-based assay for prediction of corneal drug permeability.

Eur J Pharm Sci 2018 Dec 13. Epub 2018 Dec 13.

Chemistry Department, Gedeon Richter Plc, Gyömrői út 19-21, 1107 Budapest, Hungary. Electronic address:

The present study was aimed to develop an in vitro non-cell-based method, for the measurement of corneal permeability. To this avail, the parallel artificial membrane permeability assay (PAMPA) was used for studying the effects of composition of the artificial lipid membrane, the DMSO cosolvent content of the donor phase as well as different buffer solutions in the model. Based on experimental corneal permeability values of 25 active pharmaceutical ingredients (APIs), a final model with good predictive ability (R = 0. Read More

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December 2018

Enantioselective synthesis of enantiopure β-amino alcohols via kinetic resolution and asymmetric reductive amination by a robust transaminase from Mycobacterium vanbaalenii.

J Biotechnol 2018 Dec 13. Epub 2018 Dec 13.

Laboratory of Biocatalysis and Bioprocessing, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, PR China.

Chiral β-amino alcohols are very important chiral building block for preparing bioactive compounds for use in pharmaceutical and fine chemical industries. Synthesis of chiral β-amino alcohols by transaminase is big challenging due to the strict substrate specificities and very low activity of the enzyme. In this work, a (R)-selective ω-transaminase (MVTA) from Mycobacterium vanbaalenii was employed as a biocatalyst for the first time for the synthesis of chiral β-amino alcohol via kinetic resolution and asymmetric reductive amination. Read More

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December 2018

Discovery of N-substituted 7-azaindoles as Pan-PIM kinases inhibitors - Lead optimization - Part III.

Bioorg Med Chem Lett 2018 Dec 10. Epub 2018 Dec 10.

Oncology Biology, Sanofi, 270 Albany Street, Cambridge MA 02139, United States.

N-substituted azaindoles were discovered as promising pan-PIM inhibitors. Lead optimization is described en route toward the identification of a clinical candidate. Modulation of physico-chemical properties allowed to solve inherent hERG and permeability liabilities. Read More

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December 2018
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Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold.

Bioorg Med Chem 2018 Nov 28. Epub 2018 Nov 28.

Division of Chemistry and Materials Science, Graduate School of Engineering, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan. Electronic address:

A new class of topoisomerase I inhibitors containing the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one (abbreviated as BBPI) ring system have been developed based on structure-activity relationship studies of the cytotoxic marine alkaloid lamellarin D. The pentacyclic BBPI scaffold was constructed from N-tert-butoxycarbonylpyrrole by sequential and regioselective functionalization of the pyrrole core using directed lithiation, conventional electrophilic substitution, and palladium-catalyzed cross-coupling reactions. Further N-alkylation of the scaffold followed by selective deprotection of the O-isopropyl group produced a range of N-substituted BBPI derivatives. Read More

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November 2018

Pyrrolidinone-bearing methylated and halogenated benzenesulfonamides as inhibitors of carbonic anhydrases.

Bioorg Med Chem 2018 Dec 6. Epub 2018 Dec 6.

Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio 7, Vilnius LT-10257, Lithuania.

Two series of benzenesulfonamides bearing methyl groups at ortho/ortho or meta/ortho positions and a pyrrolidinone moiety at para position were synthesized and tested as inhibitors of the twelve catalytically active human carbonic anhydrase (CA) isoforms. Observed binding affinities were determined by fluorescent thermal shift assay and intrinsic binding affinities representing the binding of benzenesulfonamide anion to the Zn(II)-bound water form of CA were calculated. Introduction of dimethyl groups into benzenesulfonamide ring decreased the binding affinity to almost all CA isoforms, but gained in selectivity towards one CA isoform. Read More

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December 2018

Design and synthesis of selective CYP1B1 inhibitor via dearomatization of α-naphthoflavone.

Bioorg Med Chem 2018 Dec 3. Epub 2018 Dec 3.

Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan. Electronic address:

Selective cytochrome P450 (CYP) 1B1 inhibition has potential as an anticancer strategy that is unrepresented in the current clinical arena. For development of a selective inhibitor, we focused on the complexity caused by sp-hybridized carbons and synthesized a series of benzo[h]chromone derivatives linked to a non-aromatic B-ring using α-naphthoflavone (ANF) as the lead compound. Ring structure comparison suggested compound 37 as a suitable cyclohexyl-core with improved solubility. Read More

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December 2018

Oral vaccination with influenza hemagglutinin combined with human pulmonary surfactant-mimicking synthetic adjuvant SF-10 induces efficient local and systemic immunity compared with nasal and subcutaneous vaccination and provides protective immunity in mice.

Vaccine 2018 Dec 13. Epub 2018 Dec 13.

Division of Enzyme Chemistry, Institute for Enzyme Research, Tokushima University, Tokushima, Japan. Electronic address:

We reported previously that a synthetic mucosal adjuvant SF-10, which mimics human pulmonary surfactant, delivers antigen to mucosal dendritic cells in the nasal cavity and promotes induction of humoral and cellular immunity. The aim of the present study was to determine the effects of oral administration of antigen combined with SF-10 (antigen-SF-10) on systemic and local immunity. Oral administration of ovalbumin, a model antigen, combined with SF-10 enhanced ovalbumin uptake into intestinal antigen presenting MHC IICD11c cells and their CD11bCD103 and CD11bCD103 subtype dendritic cells, which are the major antigen presenting subsets of the intestinal tract, more efficiently compared to without SF-10. Read More

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December 2018

Interlaboratory comparison about feasibility of insoluble particulate matter test for injections with reduced test volume in light obscuration method.

Biologicals 2018 Dec 12. Epub 2018 Dec 12.

Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, Tonomachi 3-25-26, Kawasaki-ku, Kanagawa, 210-9501, Japan.

Insoluble particulate matter test for injections in pharmacopoeia is mandatory for parenteral drug products. In this test using light obscuration, four measurements of at least 5-mL are required. Since therapeutic protein injections of low dosage volumes are getting more popular, reduction of test volumes is desired. Read More

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December 2018

Biological effects of mixed-ion beams. Part 2: The relative biological effectiveness of CHO-K1 cells irradiated by mixed- and single-ion beams.

Appl Radiat Isot 2018 Dec 5. Epub 2018 Dec 5.

Department of Molecular Bioscience, Centre for Radiation Protection Research, The Wenner-Gren Institute, Stockholm University, Universitetsvagen 10, 114 18 Stockholm, Sweden; Jan Kochanowski University, Institute of Biology, ul. Świętokrzyska 15, 25-406 Kielce, Poland.

The relative biological effectiveness (RBE) values were determined for single- and mixed-ion beams containing carbon and oxygen ions. The CHO-K1 cells were irradiated with beams with the linear energy transfer (LET) values of 236-300 and 461-470 keV/μm for C and O ions, respectively. The RBE was estimated as a function of dose, survival fraction (SF) and LET. Read More

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December 2018
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