10 results match your criteria Chemistry Of Heterocyclic Compounds[Journal]

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Privileged heterocycles: bioactivity and synthesis of 1,9-diazaspiro[5.5]undecane-containing compounds.

Chem Heterocycl Compd (N Y) 2017 5;53(8):827-845. Epub 2017 Oct 5.

Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, 6526 AJ Nijmegen, the Netherlands.

This review discusses the biological activity and synthesis of 1,9-diazaspiro[5.5]undecanes, including those ring-fused with arenes and heteroarenes and/or containing a carbonyl group at position 2. These compounds could be used for the treatment of obesity, pain, as well as various immune system, cell signaling, cardiovascular, and psychotic disorders. Read More

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http://dx.doi.org/10.1007/s10593-017-2133-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088121PMC
October 2017

Preparation and biological properties of 2-thio-containing pyrimidines and their condensed analogs.

Chem Heterocycl Compd (N Y) 2017 27;53(3):256-272. Epub 2017 Apr 27.

Zaporizhzhia State Medical University, 26 Mayakovsky Ave, Zaporizhzhia, 69035 Ukraine.

The known methods for synthesis of thioxopyrimidines and their condensed analogs with exocyclic sulfur atom are summarized and discussed. The most popular approaches are based on [3+3], [4+2], [5+1] cyclization processes or domino reactions. The literature data analysis shows that the title compounds possess diverse biological activities, such as antioxidant, radioprotective, analgesic, antiinflammatory, antihypertensive, anxiolytic, anamnestic, anticonvulsant, antimicrobial, fungicidal, herbicidal, antiviral, and anticancer. Read More

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http://dx.doi.org/10.1007/s10593-017-2048-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088342PMC

Isatin derivatives in reactions with phosphorus(III-V) compounds.

Chem Heterocycl Compd (N Y) 2015 19;51(5):421-439. Epub 2015 Jun 19.

A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, 8 Arbuzova St., Kazan, 420088 Russia.

In this review we generalize and analyze information about reactions between isatin and three-, four-, and five-coordinate phosphorus compounds, published between 1966 and 2014. Read More

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http://dx.doi.org/10.1007/s10593-015-1717-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088249PMC

Structural Analogs of Umifenovir. 1. Synthesis and Biological Activity of Ethyl 5-Hydroxy-1-Methyl-2-(-2-Phenylcyclopropyl)-1-Indole-3-Carboxylate.

Chem Heterocycl Compd (N Y) 2014 8;50(4):489-495. Epub 2014 Jun 8.

3Volgograd State Technical University, 28 Lenin Ave., Volgograd, 400005 Russia.

Ethyl 5-hydroxy-1-methyl-2-(trans-2-phenylcyclopropyl)-1H-indole-3-carboxylate is the first prototype of conformationally restricted analogs of umifenovir. It has been prepared using a one-pot method and has undergone an antiviral study. Read More

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http://dx.doi.org/10.1007/s10593-014-1499-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088350PMC

MULTICOMPONENT REACTIONS IN ALKALOID-BASED DRUG DISCOVERY.

Chem Heterocycl Compd (N Y) 2012 Apr 8;48(1):33-38. Epub 2012 May 8.

New Mexico Institute of Mining and Technology, 801 Leroy Place, Socorro, New Mexico 87801, USA.

Multicomponent reactions are emerging as a powerful tool in alkaloid-based drug discovery. This Highlight describes several recent (all published in 2011) examples of the employment of multicomponent reactions for the synthesis of biologically active alkaloids and their medicinally relevant analogues. Read More

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http://dx.doi.org/10.1007/s10593-012-0965-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130108PMC
April 2012
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Glycosyl Thioimidates as Versatile Building Blocks for Organic Synthesis.

Chem Heterocycl Compd (N Y) 2012 Apr;48(1)

University of Missouri - St. Louis, One University Boulevard, St. Louis, Missouri 63121, USA.

This review discusses the synthesis and application of glycosyl thioimidates in chemical glycosylation and oligosaccharide assembly. Although glycosyl thioimidates include a broad range of compounds, the discussion herein centers on -benzothiazolyl (SBaz), -benzoxazolyl (SBox), -thiazolinyl (STaz), and -benzimidazolyl (SBiz) glycosides. These heterocyclic moieties have recently emerged as excellent anomeric leaving groups that express unique characteristics for highly diastereoselective glycosylation and help to provide the streamlined access to oligosaccharides. Read More

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http://dx.doi.org/10.1007/s10593-012-0984-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840805PMC
April 2012
2 Reads

ORGANOCOPPER-MEDIATED TWO-COMPONENT 2'-SUBSTITUTION CASCADE TOWARDS -FUSED HETEROCYCLES.

Chem Heterocycl Compd (N Y) 2012 Mar;47(12):1516-1526

University of Illinois at Chicago, 845 West Taylor St., Chicago 60607, Illinois, USA.

Organocuprates efficiently undergo reaction with heterocyclic propargyl mesylates at low temperature to produce N-fused heterocycles. The copper reagent plays a "double duty" in this cascade transformation, which proceeds through an S2'-substitution followed by a consequent cycloisomerization step. Read More

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http://dx.doi.org/10.1007/s10593-012-0942-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910007PMC
March 2012
4 Reads

4-Hydroxy-2-quinolones 139. Synthesis, structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2-]pyrimidine-3-carboxylic acids.

Chem Heterocycl Compd (N Y) 2008 31;44(1):50. Epub 2008 May 31.

2Kharkiv Medical Academy of Postgraduate Education, Kharkiv, 61176 Ukraine.

Dialkylaminoalkylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids have been obtained as potential antiviral agents. The special features of the spatial structure of one example of the synthesized compounds have been studied. Results are given of the investigation of cytotoxicity and antiviral activity in relation to type 1 herpes virus and coronavirus. Read More

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http://dx.doi.org/10.1007/s10593-008-0012-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088292PMC

Acyclic analogs of nucleosides. Synthesis and in vitro antiviral activity of hydroxyalkyl-2-(trifluoromethylthiomethyl) benzimidazoles.

Chem Heterocycl Compd (N Y) 1989 ;25(4):410-413

1Institute of Molecular Biology, Academy of Sciences of the USSR, 117984 Moscow.

In a search for novel antiviral compounds of the 'doubly modified' nucleoside type, we have prepared 1-(4-hydroxy-2-oxabutyl)-, 1-(4-hydroxy-3-hydroxymethyl-2-oxabutyl)-, 1-(4-hydroxy-1-hydroxymethy1-2-oxabutyl)-, 1-(4-hydroxy-1-methyl-2-oxabutyl), 1-(4,5-dihydroxy-2-oxapentyl)-, 1-(5-hydroxy-2-oxapentyl), 1-(5-hydroxy-1-chloromethyl-2-oxapentyl)-, and 1-(6-hydroxy-1-chloromethyl-2-oxahexyl)-2-(trifluoromethylthiomethyl)benzimidazole. They were obtained by condensing the trimethylsilyl derivative of 2-(trifluoromethylthiomethyl) benzimidazole with alkylating agents in the presence of an equimolar mixture of trifluoromethanesulfonic acid and trimethylchlorosilane. These nucleoside analogs showed moderate antiviral activity against some RNA viruses. Read More

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http://dx.doi.org/10.1007/BF00480754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087781PMC
January 1989

Acyclic analogs of nucleosides. Synthesis of hydroxyalkyl derivatives of 2-trifluoromethyl- and 2-trifluoromethylthiobenzimidazole.

Chem Heterocycl Compd (N Y) 1988 ;24(5):514-518

1Institute of Molecular Biology, Academy of Sciences of the USSR, 117984 Moscow.

1-(2,3-Dihydroxypropyl)-, 1-(4-hydroxy-2-oxabutyl)-, 1-(3-hydroxymethyl-4-hydroxy-2-oxabutyl)-, 1-(1,5-dihydroxy-3-oxa-2-pentyl)-, 1-(5-hydroxy-3-oxa-2-pentyl)-, and 1-(4,5-dihydroxy-2-oxapentyl)-2-trifluoromethyl- and -2-trifluoromethylthiobenzimidazoles were obtained by condensation of trimethylsilyl derivatives of 2-substituted benzimidazoles with alkylating agents in the presence of SnCl, or by direct alkylation of the sodium salts of the heterocycles. Read More

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http://dx.doi.org/10.1007/BF00755691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087784PMC
January 1988
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