4,630,732 results match your criteria Chemistry Education Research And Practice[Journal]


Antibacterial activity of nitric oxide-releasing carboxymethylcellulose against periodontal pathogens.

J Biomed Mater Res A 2020 Jul 12. Epub 2020 Jul 12.

Department of Chemistry, University of North Carolina at Chapel Hill, B 3290, Chapel Hill, North Carolina.

The prevalence of periodontal disease poses a significant global health burden. Treatments for these diseases, primarily focused on removal and eradication of dental plaque biofilms, are challenging due to limited access to periodontal pockets where these oral pathogens reside. Herein, we report on the development and characterization of nitric oxide (NO)-releasing carboxymethylcellulose (CMC) derivatives and evaluate their in vitro bactericidal efficacy against planktonic Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, two prominent periodontopathogens. Read More

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http://dx.doi.org/10.1002/jbm.a.37056DOI Listing

Comparative sequencing data analysis of Ion Torrent and MinION sequencing platforms using a clinical diagnostic haematology panel.

Int J Lab Hematol 2020 Jul 12. Epub 2020 Jul 12.

Paediatric Haematology-Oncology Unit, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Introduction: Currently, two second-generation sequencing platforms-Ion Torrent and Illumina are being widely used for clinical testing and reporting of human samples. However, third-generation long read platforms like single molecule (PacBio) or direct sequencing (Nanopore) are gaining widespread interest in clinical genomics.

Aims And Objectives: The current study attempts to analyse and compare MinION sequencing data with Ion Torrent data, using a haematology ampliseq panel, to shed light on its current standing in reporting of clinical diagnostic samples. Read More

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http://dx.doi.org/10.1111/ijlh.13286DOI Listing

Strontium Substitution of Gelatin Modified Calcium Hydrogen Phosphates as Porous Hard Tissue Substitutes.

J Biomed Mater Res A 2020 Jul 12. Epub 2020 Jul 12.

Institute of Materials Science, Max Bergmann Center of Biomaterials, Technische Universität Dresden, Dresden, Germany.

Aiming at the generation of a high strontium-containing degradable bone substitute, the exchange of calcium with strontium in gelatin-modified brushite was investigated. The ion substitution showed two mineral groups, the high-calcium containing minerals with a maximum measured molar Ca/Sr ratio of 80%/20% (mass ratio 63%/37%) and the high-strontium containing ones with a maximum measured molar Ca/Sr ratio of 21%/79% (mass ratio 10%/90%). In contrast to the high-strontium mineral phases, a high mass loss was observed for the calcium-based minerals during incubation in cell culture medium (alpha-MEM), but also an increase in strength owing to dissolution and re-precipitation. Read More

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http://dx.doi.org/10.1002/jbm.a.37057DOI Listing

Effect of Low Energy Shock Wave Therapy on Intravesical Epirubicin Delivery in a Rat Model of Bladder Cancer.

BJU Int 2020 Jul 12. Epub 2020 Jul 12.

Department of Urology, Urology and Nephrology Center, Mansoura University, Egypt.

Objectives: To study the efficacy of low energy shock wave (LESW) on enhancing intravesical epirubicin (EPI) delivery in a rat model of bladder cancer (BC).

Materials And Methods: 100 female Fischer rats were randomly allocated into five groups; Control, BC, LESW, EPI and EPI plus LESW groups. After BC induction by N-butyl-N-(4-hydroxybutyl)nitrosamine, EPI (0. Read More

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http://dx.doi.org/10.1111/bju.15173DOI Listing

High Mass Resolution, Spatial Metabolite Mapping Enhances the Current Plant Gene and Pathway Discovery Toolbox.

New Phytol 2020 Jul 12. Epub 2020 Jul 12.

Department of Plant Sciences, Weizmann Institute of Science, Rehovot, 761001, Israel.

Understanding when and where metabolites accumulate provides important cues to the gene function. Mass Spectrometry Imaging (MSI) enables in situ temporal and spatial measurement of a large assortment of metabolites, providing mapping information regarding their cellular distribution. To describe the current state and technical advances of using MSI in plant sciences, we employed MSI to demonstrate its significant contribution to the study of plant specialized metabolism. Read More

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http://dx.doi.org/10.1111/nph.16809DOI Listing

The recent challenges of highly contagious COVID-19; causing respiratory infections: symptoms, diagnosis, transmission, possible vaccines, animal models and immunotherapy.

Chem Biol Drug Des 2020 Jul 12. Epub 2020 Jul 12.

Department of medicinal chemistry, National University of Pharmacy, Pushkinska str. 53, Kharkiv, 61002, Ukraine.

COVID-19 is highly contagious pathogenic viral infection initiated from Wuhan seafood wholesale market of China on December 2019 and spread rapidly around the whole world due to onward transmission. This recent outbreak of novel coronavirus (CoV) was believed to be originated from bats and causing respiratory infections such as common cold, dry cough, fever, headache, dyspnea, pneumonia and finally Severe Acute Respiratory Syndrome (SARS) in humans. For this widespread zoonotic virus, human-to-human transmission has resulted in nearly 83 lakh cases in 213 countries and territories with 4,50,686 deaths as on 19th June 2020. Read More

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http://dx.doi.org/10.1111/cbdd.13761DOI Listing

Architecture and self-assembly of the SARS-CoV-2 nucleocapsid protein.

Protein Sci 2020 Jul 12. Epub 2020 Jul 12.

Department of Cellular & Molecular Medicine, University of California San Diego, La Jolla, CA.

The COVID-2019 pandemic is the most severe acute public health threat of the twenty-first century. To properly address this crisis with both robust testing and novel treatments, we require a deep understanding of the life cycle of the causative agent, the SARS-CoV-2 coronavirus. Here, we examine the architecture and self-assembly properties of the SARS-CoV-2 nucleocapsid protein, which packages viral RNA into new virions. Read More

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http://dx.doi.org/10.1002/pro.3909DOI Listing

Perturbation of Specific Signaling Pathways Is Involved in Initiation of Mouse Liver Fibrosis.

Hepatology 2020 Jul 12. Epub 2020 Jul 12.

Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China.

To identify the regulatory role of protein phosphatase 2A (PP2A) in the development of liver disease, we generated a mouse model with hepatocyte-specific deletion of Ppp2r1a gene (encoding PP2A Aα subunit). Homozygote (HO) mice and matched wild-type (WT) littermates were investigated at 3, 6, 9, 12, 15, and 18 months-of-age, respectively. Pathological examination showed that PP2A Aα deficiency in hepatocytes resulted in progressive liver fibrosis phenotype from 9 months-of-age. Read More

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http://dx.doi.org/10.1002/hep.31457DOI Listing

Universal response pattern of phytoplankton growth rates to increasing CO.

New Phytol 2020 Jul 12. Epub 2020 Jul 12.

Institute for Marine and Antarctic Studies, University of Tasmania, 20 Castray Esplanade, Battery Point, Tasmania, 7004, Australia, Hobart.

Phytoplankton growth rate is a key variable controlling species succession and ecosystem structure throughout the surface ocean. Carbonate chemistry conditions are known to influence phytoplankton growth rates but there is no conceptual framework allowing us to compare growth rate responses across taxa. Here we analyse the literature to show that phytoplankton growth rates follow an optimum curve response pattern whenever the tested species is exposed to a sufficiently large gradient in proton (H ) concentrations. Read More

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http://dx.doi.org/10.1111/nph.16806DOI Listing

Correction to: H, C, N backbone and IVL methyl group resonance assignment of the fungal β-glucosidase from Trichoderma reesei.

Biomol NMR Assign 2020 Jul 11. Epub 2020 Jul 11.

YSBL, Department of Chemistry, University of York, Heslington, York, UK.

In the original publication of the article, the name of one of the authors is incorrect. The author's name is Eiso AB, but was modified to A. B. Read More

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http://dx.doi.org/10.1007/s12104-020-09967-2DOI Listing

Cyanotoxin Analysis and Amino Acid Profiles of Cyanobacterial Food Items from Chad.

Neurotox Res 2020 Jul 11. Epub 2020 Jul 11.

Brain Chemistry Labs, Box 3464, Jackson, WY, 83001, USA.

In some parts of the world, cyanobacteria are used as a food in the human diet, due to their ready availability. Lake Chad, has long been a traditional site for the collection of Arthrospira fusiformis which is dried and processed at the lake into thin wafers called Dihé for later consumption or is transported to market for sale. However, Dihé purchased from markets in Chad has not been analyzed for known cyanobacterial toxins or assessed for total amino acid content. Read More

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http://dx.doi.org/10.1007/s12640-020-00240-xDOI Listing

Metallo-ß-lactamases: a review.

Mol Biol Rep 2020 Jul 11. Epub 2020 Jul 11.

Independent Researcher, Yerevan, Armenia.

Microbial pathogens including Enterobacteriaceae family members bear different antibiotic resistance genes comprising Extended-Spectrum-ß-Lactamases (ESBLs) and Metallo-ß-Lactamases (MBLs) on their chromosomes and mobile genetic elements such as plasmids and transposons. Because of the clinical concern regarding MBLs in global public healthcare system, this review focuses on different characteristics of MBLs. For preparing this review article, different databases, websites and search engines such as MEDLINE, SCOPUS, SCIENCEDIRECT and GOOGLE SCHOLAR were searched via MeSH keywords of Enterobacteriaceae, Escherichia coli, Klebsiella pneumoniae, MBL and Bioinformatics. Read More

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http://dx.doi.org/10.1007/s11033-020-05651-9DOI Listing

Metabolic crosstalk in the tumor microenvironment regulates antitumor immunosuppression and immunotherapy resisitance.

Cell Mol Life Sci 2020 Jul 11. Epub 2020 Jul 11.

Department of Stomatology, NHC Key Laboratory of Carcinogenesis, Xiangya Hospital, Central South University, Changsha, 410078, China.

The successful treatment of human cancers by immunotherapy has been made possible by breakthroughs in the discovery of immune checkpoint regulators, including CTLA-4 and PD-1/PD-L1. However, the immunosuppressive effect of the tumor microenvironment still represents an important bottleneck that limits the success of immunotherapeutic approaches. The tumor microenvironment influences the metabolic crosstalk between tumor cells and tumor-infiltrating immune cells, creating competition for the utilization of nutrients and promoting immunosuppression. Read More

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http://dx.doi.org/10.1007/s00018-020-03581-0DOI Listing

Improved synthesis of long-chain alkyl glucosides catalyzed by an engineered β-glucosidase in organic solvents and ionic liquids.

Biotechnol Lett 2020 Jul 11. Epub 2020 Jul 11.

Department of Biochemistry, Faculty of Science, and Center for Advanced Studies in Tropical Natural Resources, NRU-KU, Kasetsart University, Bangkok, Thailand.

Objective: To synthesize octyl β-D-glucopyranoside (OG) and decyl β-D-glucopyranoside (DG) in three non-aqueous reaction systems, namely organic solvents, ionic liquids and co-solvent mixtures, via reverse hydrolysis reactions catalyzed by the N189F dalcochinase mutant.

Results: The highest yield of OG (67 mol%) was obtained in the reaction containing 0.5 M glucose, 3 unit ml enzyme in 20% (v/v) octanol and 70% (v/v) [BMIm][PF] at 30 °C. Read More

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http://dx.doi.org/10.1007/s10529-020-02960-8DOI Listing

Non-clinical toxicity of (+)-limonene epoxide and its physio-pharmacological properties on neurological disorders.

Naunyn Schmiedebergs Arch Pharmacol 2020 Jul 11. Epub 2020 Jul 11.

Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, 64049-550, Brazil.

The compound (+)-limonene epoxide has antioxidant, anxiolytic, and antihelminthic properties. However, investigations to determine its long-term exposure were not performed. We investigated the systemic toxicological profile after chronic exposure as well as the antidepressant and antiepileptic potentialities of (+)-limonene epoxide on mice. Read More

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http://dx.doi.org/10.1007/s00210-020-01943-wDOI Listing

Environmental and health risk assessment of agricultural areas adjacent to uranium ore fields in Brazil.

Environ Geochem Health 2020 Jul 11. Epub 2020 Jul 11.

Biophysical Environmental Chemistry Group, Department of Chemistry, University of Montreal, Montreal, QC, Canada.

To investigate the risks posed by trace and rare earth elements (REEs) in two tropical uranium ore fields, metal concentrations from 50 vegetable samples (corn and soybean) and their corresponding agricultural soils were evaluated in a U mining area and a U-rich coal mining area in Brazil. Samples from both areas had metal concentrations (REE: La to Lu, and trace elements: As, Pb, Cd, Ni, Cu, Cr, Mn, Zn, Ba, U, Sr) that were higher than the guidelines proposed by the Brazilian environmental agency. Soils from the U mining area (Poços de Caldas) generally had higher contents of trace elements than the coal mining area (Figueira), with the exception of Ni and Cr, indicating a higher risk of pollution, which was confirmed by a pollution load index that was greater than unity. Read More

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http://dx.doi.org/10.1007/s10653-020-00659-3DOI Listing

Electrochemical sensor based on CuSe for determination of dopamine.

Mikrochim Acta 2020 Jul 11;187(8):440. Epub 2020 Jul 11.

Department of Chemistry, Missouri University of Science & Technology, Rolla, MO, 65409, USA.

A simple binary copper selenide, CuSe nanostructure, has been investigated as electrochemical sensor for dopamine detection. The hydrothermally synthesized and electrodeposited CuSe nanostructures showed high sensitivity for dopamine detection with low limit of detection (LOD). A sensitivity of 26 μA/μM. Read More

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http://dx.doi.org/10.1007/s00604-020-04405-5DOI Listing

Two Novel Variants in the Protein S Gene PROS1 Are Associated with Protein S Deficiency and Thrombophilia.

Acta Haematol 2020 Jul 10:1-4. Epub 2020 Jul 10.

Institute of Clinical Chemistry, University Hospital of Schleswig-Holstein, Lübeck/Kiel, Germany.

Protein S (PS) is an important anticoagulant. Its main function is to act as a non-enzymatical cofactor of activated protein C. PS deficiency is defined as low plasma levels of PS and/or loss of function associated with variable risk of venous thromboembolism (VTE). Read More

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http://dx.doi.org/10.1159/000508525DOI Listing

Effects of Glycosaminoglycan from Urechis unicinctus on ADP-Induced Platelet Calcium and Membrane Glycoprotein Expressions in Rats.

Acta Haematol 2020 Jul 10:1-4. Epub 2020 Jul 10.

Tianjin Key Laboratory of Marine Resource and Chemistry, Tianjin Marine Environmental Protection and Restoration Technology Engineering Center, College of Marine and Environment, Tianjin University of Science and Technology, Tianjin, China.

Background: Previous studies had shown that glycosaminoglycan (GAG) from Urechis unicinctus exerts an obvious antiplatelet aggregation effect.

Objective: This study aims to investigate the effects of GAG from Urechis unicinctus on ADP-induced platelet calcium and membrane glycoprotein expressions in rats.

Methods: Fura-2/AM fluorescence probe was used to measure intracytosolic free-calcium concentration ([Ca2+]i) of platelets and calculate platelet calcium influx and release concentrations. Read More

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http://dx.doi.org/10.1159/000505769DOI Listing

Timing, prevalence, and dynamics of thyroid disorders in children and adolescents affected with Down syndrome.

J Pediatr Endocrinol Metab 2020 Jul 11. Epub 2020 Jul 11.

Pediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, Pavia, Italy.

Objectives Limited data on the evolution of thyroid disorders (TD) in Down syndrome (DS) are available. We characterized the timing, prevalence, and dynamics of TD in patients with DS during a long-term follow-up. Methods We retrospectively evaluated 91 children and adolescents with DS (12. Read More

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http://dx.doi.org/10.1515/jpem-2020-0119DOI Listing

Screening for celiac disease among children with overweight and obesity: toward exploring celiac iceberg.

J Pediatr Endocrinol Metab 2020 Jul 13. Epub 2020 Jul 13.

Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.

Background The coexistence of celiac disease (CD) and obesity/overweight is not unusual. Objective We investigate the prevalence and clinical presentation of CD, detected by screening, among children with excessive weight gain. Methods We enrolled 200 children referred for overweight/obesity to our outpatient clinic. Read More

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http://dx.doi.org/10.1515/jpem-2020-0076DOI Listing

A ROS responsive nanomedicine with enhanced photodynamic therapy via dual mechanisms: GSH depletion and biosynthesis inhibition.

J Photochem Photobiol B 2020 Jul 5;209:111955. Epub 2020 Jul 5.

College of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing, Jiangsu 210023, China; School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng, Jiangsu 224051, China. Electronic address:

Reduced glutathione (GSH, containing sulfydryl) inside cancer cells strongly consumes reactive oxygen species (ROS) in photodynamic therapy (PDT) process to reduce PDT effect. Thiol-ene click reaction is a classic method to couple sulfydryl and alkene groups. However, little effort was dedicated to developing medicines for GSH depletion based on this reaction. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2020.111955DOI Listing

Weak hydrogen bonds between alkyl halides and amides: The microwave spectroscopic and theoretical study of the difluoromethane⋯formamide complex.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 2;241:118681. Epub 2020 Jul 2.

School of Chemistry and Chemical Engineering, Chongqing University, Daxuecheng South Rd. 55, 401331 Chongqing, China. Electronic address:

The pure rotational spectrum of the complex of difluoromethane with formamide was investigated by means of microwave spectroscopy supplemented with theoretical calculations. The hyperfine structure arising from the N nuclear quadrupole coupling effect was completely resolved. The most stable isomer that displays the C symmetry with the ∠HCH angle of difluoromethane being bisected by the ab-plane of formamide was detected. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118681DOI Listing

Chitosan-based molecular imprinted polymer for extraction and spectrophotometric determination of ketorolac in human plasma.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 4;241:118668. Epub 2020 Jul 4.

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Tanta University, 31111, Egypt; Pharmaceutical Services Center, Faculty of Pharmacy, Tanta University, 31111, Egypt. Electronic address:

A selective chitosan-based ion exchange molecular imprinted polymer (MIP) was prepared for ketorolac (KET) using the sol-gel method and glutaraldehyde as a crosslinker. The nonimprinted polymer (NIP) was prepared and used as a control, during the whole experiment. The chemical and morphological characteristics of the prepared polymers were investigated using FTIR and SEM, respectively. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118668DOI Listing

Selective bioimaging of cancer cells and detection of HSA with indomethacin-based fluorescent probes.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 6;241:118685. Epub 2020 Jul 6.

Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China. Electronic address:

Two fluorescent probes were designed by connecting indomethacin to coumarin through different linkers. The introduction of indomethacin quenched the fluorescence of coumarin-based probes with apparent red-shifts in the absorption and emission maxima, probably due to the photoinduced electron transfer (PET) from the indomethacin to the fluorophore and the formation of folding conformation. The addition of human serum albumin (HSA) triggered about 40-fold fluorescence enhancements of ADC-IMC-2 and ADC-IMC-6 with 85 nm blue-shifts. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118685DOI Listing

Simultaneous determination of taxoids and flavonoids in twigs and leaves of three Taxus species by UHPLC-MS/MS.

J Pharm Biomed Anal 2020 Jul 2;189:113456. Epub 2020 Jul 2.

Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin, 150040, PR China; Engineering Research Center of Forest Bio-Preparation, Ministry of Education, Northeast Forestry University, Harbin 150040, PR China; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, 150040, PR China.

Taxus species are highly concerned due to the presence of anticancer taxoids (especially paclitaxel) and health beneficial flavonoids. For the first time, an UHPLC-MS/MS method was developed for the simultaneous determination of seven taxoids and seven flavonoids in twigs and leaves of three Taxus species. The satisfactory separation of fourteen target compounds was achieved within 5 min of running time on an Agilent ZORBAX Eclipse Plus C18 column (50 mm × 2. Read More

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http://dx.doi.org/10.1016/j.jpba.2020.113456DOI Listing

Advances in G protein-coupled receptor high-throughput screening.

Curr Opin Biotechnol 2020 Jul 9;64:210-217. Epub 2020 Jul 9.

School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, United States; School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, United States. Electronic address:

G protein-coupled receptors (GPCRs) detect compounds on the cell surface and are the starting point of a number of medically relevant signaling cascades. Indeed, over 30% of FDA approved drugs target GPCRs, making them a primary target for drug discovery. Computational and experimental high-throughput screening (HTS) approaches of clinically relevant GPCRs are a first-line drug discovery effort in biomedical research. Read More

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http://dx.doi.org/10.1016/j.copbio.2020.06.004DOI Listing

Recommendations for the conduct of systematic reviews in toxicology and environmental health research (COSTER).

Environ Int 2020 Jul 9;143:105926. Epub 2020 Jul 9.

Lancaster Environment Centre, Lancaster University, Lancaster LA1 4YQ, UK. Electronic address:

Background: There are several standards that offer explicit guidance on good practice in systematic reviews (SRs) for the medical sciences; however, no similarly comprehensive set of recommendations has been published for SRs that focus on human health risks posed by exposure to environmental challenges, chemical or otherwise.

Objectives: To develop an expert, cross-sector consensus view on a key set of recommended practices for the planning and conduct of SRs in the environmental health sciences.

Methods: A draft set of recommendations was derived from two existing standards for SRs in biomedicine and developed in a consensus process, which engaged international participation from government, industry, non-government organisations, and academia. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105926DOI Listing

Prenatal exposure to benzotriazoles and benzothiazoles and cord blood mitochondrial DNA copy number: A prospective investigation.

Environ Int 2020 Jul 9;143:105920. Epub 2020 Jul 9.

State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan 430030, Hubei, PR China. Electronic address:

Background: Mitochondria are sensitive to environmental toxicants due to the limited repair capacity. Exposure to benzotriazoles (BTRs) and benzothiazoles (BTHs) may contribute to adverse health outcomes through oxidative stress, which may interfere with mitochondrial function. However, the mitochondrial effects of exposure to BTs (BTRs and BTHs) have not yet been elucidated, particularly in human investigations. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105920DOI Listing

Transformations of AgS nanoparticles in simulated human gastrointestinal tract: Impacts of the degree and origin of sulfidation.

J Hazard Mater 2020 Jul 4;401:123406. Epub 2020 Jul 4.

Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018, China. Electronic address:

Engineered silver sulfide nanoparticles (e-AgS-NPs) are used in industry and can be released into the environment. Besides e-AgS-NPs, transformed silver sulfide nanoparticles (t-AgS-NPs) from silver nanoparticles are more likely to be the form that is widely distributed in the environment. Both e-AgS-NPs and t-AgS-NPs may be ingested and get into human gastrointestinal tract (GIT) through trophic transfer, posing a potential threat to human health. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123406DOI Listing

Quaternary phosphonium modified cellulose microsphere adsorbent for Tc decontamination with ultra-high selectivity.

J Hazard Mater 2020 Jun 30;401:123354. Epub 2020 Jun 30.

Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, the Key Laboratory of Polymer Chemistry and Physics of the Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. Electronic address:

Decontamination of radioactive TcO from nuclear wastes is increasingly crucial for spent nuclear fuel reprocessing and environmental remediation. In the presence of a large excess of competitive anions, the selective separation of TcO is a major challenge for adsorbents. Herein, by using pre-radiation induced grafting polymerization, we have modified economical and environmentally friendly cellulose microspheres to obtain quaternary phosphonium decorated TcO adsorbents with an ultra-high selectivity, designated CMS-g-VBPPhNO. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123354DOI Listing

TBBPA, TBBPS, and TCBPA disrupt hESC hepatic differentiation and promote the proliferation of differentiated cells partly via up-regulation of the FGF10 signaling pathway.

J Hazard Mater 2020 Jun 30;401:123341. Epub 2020 Jun 30.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address:

Halogenated flame retardants (HFRs), including Tetrabromobisphenol A (TBBPA), Tetrabromobisphenol S (TBBPS), and Tetrachlorobisphenol A (TCBPA), are widely applied in the manufacturing industry to improve fire safety and can be detected in pregnant women's serum at nanomolar levels. Thus, it is necessary to pay attention to the three HFR potential development toxicity, which has not been conclusively addressed yet. The liver is the main organ that detoxifies our body; TBBPA exposure may lead to increased liver weight in rodents. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123341DOI Listing

Drugs of abuse and their metabolites in river sediments: Analysis, occurrence in four Spanish river basins and environmental risk assessment.

J Hazard Mater 2020 Jun 25;401:123312. Epub 2020 Jun 25.

Water, Environmental, and Food Chemistry Unit (ENFOCHEM), Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Barcelona, Spain. Electronic address:

The environmental impact produced by the presence of drugs of abuse in sediments has been scarcely studied to date, even though many of them may adsorb onto particulate matter due to their physical-chemical properties. This study presents an analytical method for the determination of 20 drugs of abuse and metabolites in sediments. The validated method was satisfactory in terms of linearity (r >0. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123312DOI Listing

The effects of ionizing radiation on the structure and antioxidative and metal-binding capacity of the cell wall of microalga Chlorella sorokiniana.

Chemosphere 2020 Jul 8;260:127553. Epub 2020 Jul 8.

Department of Life Sciences, Institute for Multidisciplinary Research, University of Belgrade, Kneza Višeslava 1, 11030, Belgrade, Serbia. Electronic address:

The impact of ionizing radiation on microorganisms such as microalgae is a topic of increasing importance for understanding the dynamics of aquatic ecosystems in response to environmental radiation, and for the development of efficient approaches for bioremediation of mining and nuclear power plants wastewaters. Currently, nothing is known about the effects of ionizing radiation on the microalgal cell wall, which represents the first line of defence against chemical and physical environmental stresses. Using various microscopy, spectroscopy and biochemical techniques we show that the unicellular alga Chlorella sorokiniana elicits a fast response to ionizing radiation. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127553DOI Listing

Parental exposure to the synthetic estrogen 17α-ethinylestradiol (EE2) affects offspring development in the Sydney rock oyster, Saccostrea glomerata.

Environ Pollut 2020 Jul 3;266(Pt 1):114994. Epub 2020 Jul 3.

School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia. Electronic address:

Very little is currently known regarding the effects of estrogenic endocrine disrupting chemicals on embryonic and larval development in molluscs, nor the potential effects of parental (F) exposure on resultant F offspring. In this study, we assessed the embryotoxic impacts of exposure to environmentally relevant concentrations of the synthetic estrogen, 17α-ethinylestradiol (EE2), to male and female parents (50 ng/L) and their offspring (5 and 50 ng/L) in the native Australian Sydney rock oyster, Saccostrea glomerata. There were no detectable effects of parental exposure on fertilisation success, proportions of early larval (F) morphs and unfertilised eggs. Read More

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http://dx.doi.org/10.1016/j.envpol.2020.114994DOI Listing

Nanoparticles as antibiotic-delivery vehicles (ADVs) overcome resistance by MRSA and other MDR bacterial pathogens: the grenade hypothesis.

J Glob Antimicrob Resist 2020 Jul 9. Epub 2020 Jul 9.

Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC, 29208, USA. Electronic address:

Objectives: The aim of this study was to examine how the concentrated delivery of less-effective antibiotics, such as the β-lactam penicillin-G, by linkage to nanoparticles (NPs) could influence the killing efficiency against various pathogenic bacteria including methicillin-resistant-Staphylococcus aureus (MRSA) and other multi-drug resistant (MDR) strains.

Methods: The β-lactam antibiotic penicillin-G (PenG) was passively-sorbed to fluorescent polystyrene NPs (20 nm) that were surface-functionalized with either carboxylic acid- (COO--NPs) or sulfate-groups (SO4--NPs) to form PenG- NPs complex. Antimicrobial activities of PenG-NPs were evaluated against Gram-negative and Gram-positive bacteria, including antibiotic resistant strains. Read More

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http://dx.doi.org/10.1016/j.jgar.2020.06.023DOI Listing

Effect of applying calcium peroxide on the accumulation of arsenic in rice plants grown in arsenic-elevated paddy soils.

Environ Pollut 2020 Jul 4;266(Pt 2):115140. Epub 2020 Jul 4.

Department of Agricultural Chemistry, National Taiwan University, Taipei 10617, Taiwan. Electronic address:

Water management such as drainage for creating aerobic conditions is considered to be an adequate method for reducing the accumulation of arsenic (As) in rice grains; however, it is difficult to conduct drainage operations in some areas that experience a lengthy rainy season as well as in soils with poor drainage. In this regard, application of oxygen-releasing compounds (ORCs) may be an alternative method for maintaining aerobic conditions even under flooding in paddy soils. Therefore, a pot experiment was conducted to investigate the effects of application of an ORC, calcium peroxide (CaO), on the growth and accumulation of As in rice plants grown in As-contaminated paddy soils. Read More

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http://dx.doi.org/10.1016/j.envpol.2020.115140DOI Listing

The removal of bisphenols and other contaminants of emerging concern by hydrodynamic cavitation: From lab-scale to pilot-scale.

Sci Total Environ 2020 Jul 4;743:140724. Epub 2020 Jul 4.

Jožef Stefan Institute, Jamova cesta 39, 1000 Ljubljana, Slovenia; International Postgraduate School Jožef Stefan, Jamova cesta 39, 1000 Ljubljana, Slovenia. Electronic address:

The rapid growth in the variety and quantity of contaminants of emerging concern (CEC) in wastewater indicates the necessity for developing efficient and environmentally friendly methods for their removal. This study investigates the removal efficiency of 46 CEC, including 12 bisphenols, from wastewater using a lab and pilot-scale hydrodynamic cavitation generator alone and in combination with UV illumination (pilot-scale). During lab-scale cavitation, the highest removal efficiencies of bisphenols (15-63%) for this specific design of cavitator were obtained at a rotational frequency (v) = 9500 rpm and time (t) = 10 min. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140724DOI Listing

Eu@metal-organic frameworks encapsulating carbon dots as ratiometric fluorescent probes for rapid recognition of anthrax spore biomarker.

Sci Total Environ 2020 Jul 3;743:140692. Epub 2020 Jul 3.

College of Chemistry, Liaoning University, 66 Chongshan Middle Road, Shenyang, Liaoning 110036, People's Republic of China. Electronic address:

Anthrax spores pose a serious threat to human well-being and life, so it is highly desirable to develop a rapid, sensitive, and selective quantitative assay of calcium pyridine dicarboxylate (CaDPA) as a biomarker of anthrax spores. Herein, carbon dots (CDs) chelated Eu@metal-organic framework (Eu-MOFs) as dual-emissive ratiometric fluorescent (RF) probe was successfully fabricated by a simple one-pot in situ selective self-assembly synthetic strategy. The developed RF probe has an effective self-calibration function, which performs a highly sensitive and selective recognition of CaDPA in water and human serum sample. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140692DOI Listing

Synthesis, antiproliferative activity and SAR analysis of (-)-cleistenolide and analogues.

Eur J Med Chem 2020 Jul 6;202:112597. Epub 2020 Jul 6.

Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, Novi Sad, Serbia; Serbian Academy of Sciences and Arts, Knez Mihajlova 35, 11000, Belgrade, Serbia. Electronic address:

A new, modified total synthesis of (-)-cleistenolide (1) and sixteen new analogues or derivatives was achieved starting from commercially available 1,2-O-isopropylidene-α-d-glucofuranose. The synthesis of 1 proceeds in six steps and 67% overall yield, using single-carbon atom degradation of a protected chiral precursor, (Z)-selective Wittig olefination, and acid catalyzed δ-lactonization. A new Lewis acid promoted procedure for one-pot O-debenzylation/O-acylation has been developed to complete the synthesis of natural product 1 and selected analogues. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112597DOI Listing

New manganese(II), iron(II), cobalt(II), nickel(II) and copper(II) saccharinate complexes of 2,6-bis(2-benzimidazolyl)pyridine as potential anticancer agents.

Eur J Med Chem 2020 Jul 3;202:112535. Epub 2020 Jul 3.

Department of Physics, Faculty of Sciences, Dokuz Eylul University, 35210, Izmir, Turkey.

New mononuclear complexes [Mn(NO)(sac)(HO)(bzimpy)]·2DMF (Mn), [Fe(sac)(HO)(bzimpy)]·2HO (Fe), [Co(bzimpy)](sac)·2HO (Co), [Ni(bzimpy)](sac)·HO·i-PrOH (Ni) and [Cu(sac)(bzimpy)]·3DMF (Cu) (sac = saccharinate and bzimpy = 2,6-bis(2-benzimidazolyl)pyridine) were synthesized and structurally characterized by elemental analysis, UV-Vis, IR, ESI-MS and X-ray diffraction. The anticancer activity of the metal complexes against A549 (lung), MCF-7 (breast), HT29 (colon) cancer cells and MCF10A (normal human breast epithelial) cells was tested and compared with those of cisplatin and bzimpy. The complexes displayed potent cytotoxic activity especially in MCF-7 and A549 cell lines, but they were practically inactive against the normal cells. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112535DOI Listing

Bimodal porous silica nanomaterials as sorbents for an efficient and inexpensive determination of aflatoxin M in milk and dairy products.

Food Chem 2020 Jul 5;333:127421. Epub 2020 Jul 5.

Department of Analytical Chemistry, Faculty of Chemistry, Universitat de València, Dr Moliner 50, 46100 Burjassot, Valencia, Spain. Electronic address:

An extraction procedure was developed for the determination of aflatoxin M in milk and dairy products. A sorbent based on UVM-7 mesoporous silica was used as solid phase for the sample clean-up, and the analyte determination was carried out by HPLC coupled to a fluorescence detector. The material architecture was characterized by transmission electronic microscopy, X-ray diffraction, Si NMR and nitrogen adsorption-desorption. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127421DOI Listing

Process properties of an l-amino acid oxidase from Hebeloma cylindro-sporum for the synthesis of phenylpyruvic acid from l-phenylalanine.

J Biotechnol 2020 Jul 9. Epub 2020 Jul 9.

Chair of Industrial Organic Chemistry and Biotechnology, Faculty of Chemistry, Bielefeld University, Universitätsstr. 25, 33615, Bielefeld, Germany. Electronic address:

The biocatalytic oxidation of amino acids represents an attractive approach towards the synthesis of α-keto acids, which are interest for various industrial applications. As l-amino acids are readily available from fermentation processes, these natural amino acids can serve as substrates in combination with an L-amino acid oxidase. Besides an aqueous phase as reaction medium, a further advantage of such a process is the utilization of air as oxidation agent. Read More

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http://dx.doi.org/10.1016/j.jbiotec.2020.07.005DOI Listing

Silver complexes with heterocyclic thioamide and tertiary arylphosphane ligands: Synthesis, crystal structures, in vitro and in silico antibacterial and cytotoxic activity, and interaction with DNA.

J Inorg Biochem 2020 Jul 4;210:111167. Epub 2020 Jul 4.

Laboratory of Inorganic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece. Electronic address:

Herein we report on the synthesis and molecular structures of six silver(I) mixed-ligand complexes containing a heterocyclic thioamide [4-phenyl-imidazole-2-thione (phimtH) or 2,2,5,5-tetramethyl-imidazolidine-4-thione (tmimdtH)] and a tertiary arylphosphane [triphenylphosphine (PPh), tri-o-tolylphosphane (totp)] or diphosphane [(1,2-bis(diphenylphosphano)ethane (dppe), bis(2-diphenylphosphano-phenyl)ether (DPEphos) or 4,5-bis(diphenylphosphano)-9,9-dimethylxanthene) (xantphos)]. The interaction of the compounds with calf-thymus DNA (CT DNA), as monitored directly via UV-vis spectroscopy and DNA-viscosity measurements and indirectly via its competition with ethidium bromide for DNA-intercalation sites, is suggested to take place via an intercalative mode. The new complexes show selective significant in vitro antibacterial activity against four bacterial strains. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2020.111167DOI Listing

Novel glucosinolate metabolism in larvae of the leaf beetle Phaedon cochleariae.

Insect Biochem Mol Biol 2020 Jul 9:103431. Epub 2020 Jul 9.

Department of Chemical Ecology, Bielefeld University, Universitätsstr. 25, 33615, Bielefeld, Germany. Electronic address:

Plants of the Brassicales are defended by a binary system, in which glucosinolates are degraded by myrosinases, forming toxic breakdown products such as isothiocyanates and nitriles. Various detoxification pathways and avoidance strategies have been found that allow different herbivorous insect taxa to deal with the glucosinolate-myrosinase system of their host plants. Here, we investigated how larvae of the leaf beetle species Phaedon cochleariae (Coleoptera: Chrysomelidae), a feeding specialist on Brassicaceae, cope with this binary defence. Read More

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http://dx.doi.org/10.1016/j.ibmb.2020.103431DOI Listing

Design, synthesis, molecular docking and anticancer evaluations of 5-benzylidenethiazolidine-2,4-dione derivatives targeting VEGFR-2 enzyme.

Bioorg Chem 2020 Jun 30;102:104059. Epub 2020 Jun 30.

MD in Clinical Pathology, Blood Bank Specialist, Blood Bank Directorate Manager, Ministry of Health, Cairo, Egypt.

Novel series of 5-benzylidenethiazolidine-2,4-dione derivatives 4-8 were designed, synthesized and evaluated for anticancer activity against HepG2, HCT-116 and MCF-7 cell lines. MCF-7 was the most sensitive cell line to the influence of the new derivatives. In particular, compound 8 was found to be the most potent derivative overall the tested compounds against the three HepG2, HCT116 and MCF-7 cancer cell lines with IC = 11. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.104059DOI Listing

Extracellular Vesicles Derived from Plasmodium-infected and Non-infected Red Blood Cells as Targeted Drug Delivery Vehicles.

Int J Pharm 2020 Jul 9:119627. Epub 2020 Jul 9.

Nanomalaria Group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain; Barcelona Institute for Global Health (ISGlobal, Hospital Clínic-Universitat de Barcelona), Barcelona, Spain; Nanoscience and Nanotechnology Institute (IN2UB, UB), Barcelona, Spain. Electronic address:

Among several factors behind drug resistance evolution in malaria is the challenge of administering overall doses that are not toxic for the patient but that, locally, are sufficiently high to rapidly kill the parasites. Thus, a crucial antimalarial strategy is the development of drug delivery systems capable of targeting antimalarial compounds to Plasmodium with high specificity. In the present study, extracellular vesicles (EVs) have been evaluated as a drug delivery system for the treatment of malaria. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119627DOI Listing

The voltage-gated potassium channel K1.3 as a therapeutic target for venom-derived peptides.

Biochem Pharmacol 2020 Jul 9:114146. Epub 2020 Jul 9.

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia; ARC Centre for Fragment-Based Design, Monash University, Parkville, Victoria 3052, Australia. Electronic address:

The voltage-gated potassium channel K1.3 is a well-established therapeutic target for a range of autoimmune diseases, in addition to being the site of action of many venom-derived peptides. Numerous studies have documented the efficacy of venom peptides that target K1. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114146DOI Listing

Estimation of the ligand-binding free energy of checkpoint kinase 1 via non-equilibrium MD simulations.

J Mol Graph Model 2020 Jun 26;100:107648. Epub 2020 Jun 26.

NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City, Viet Nam. Electronic address:

Checkpoint kinase 1 (CHK1) is a serine/threonine-protein kinase that is involved in cell cycle regulation in eukaryotes. Inhibition of CHK1 is thus considered as a promising approach in cancer therapy. In this study, the fast pulling of ligand (FPL) process was applied to predict the relative binding affinities of CHK1 inhibitors using non-equilibrium molecular dynamics (MD) simulations. Read More

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http://dx.doi.org/10.1016/j.jmgm.2020.107648DOI Listing

Computational study on atom-economic alkyne hydrotelluration reaction using benchmarked ECP for Te.

J Mol Graph Model 2020 Jul 2;100:107659. Epub 2020 Jul 2.

Department of Chemistry, University of Kerala, Kerala, 695581, India.

Geometry and energy calibration studies are done for arriving at a proper ECP for tellurium containing compounds. Among the various d-function included ECPs cc-pwCVTZ-PP and def2-TZVP give more reliable results. Non-catalytic and base/radical initiated hydrotelluration reactions are computationally studied using the calibrated def2-TZVP, with a special focus on the regio-and stereoselective formation of vinyl tellurides. Read More

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http://dx.doi.org/10.1016/j.jmgm.2020.107659DOI Listing
July 2020
1.722 Impact Factor
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