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    Design, synthesis, conformational and molecular docking study of some novel acyl hydrazone based molecular hybrids as antimalarial and antimicrobial agents.
    Chem Cent J 2017 Nov 14;11(1):115. Epub 2017 Nov 14.
    Department of Microbiology, Kurukshetra University, Kurukshetra, 136119, India.
    Background: Acyl hydrazones are an important class of heterocyclic compounds promising pharmacological characteristics. Malaria is a life-threatening mosquito-borne blood disease caused by a plasmodium parasite. In some places, malaria can be treated and controlled with early diagnosis. Read More

    Simultaneous determination of brazilin and protosappanin B in Caesalpinia sappan by ionic-liquid dispersive liquid-phase microextraction method combined with HPLC.
    Chem Cent J 2017 Nov 13;11(1):114. Epub 2017 Nov 13.
    Institute of Chinese Materia Medica, Henan University, Kaifeng, Henan, 475004, China.
    The conditions of heating, ionic liquid-based ultrasonic-assisted extraction combined with reverse-phase high performance liquid chromatography were optimized to simultaneously isolate and determinate brazilin and protosappanin B in Caesalpinia sappan. Ionic liquids, including [BMIM]Br, [BMIM]BF4, [BMIM]PF6 and [HMIM]PF6, were selected as extraction solvents while methanol, acetone, acetonitrile, ethanol and water were selected as dispersants. The chromatographic column was Purospher star RP-C18 (250 mm × 4. Read More

    Antimicrobial and antioxidant potential of different solvent extracts of the medicinal plant Geum urbanum L.
    Chem Cent J 2017 Nov 7;11(1):113. Epub 2017 Nov 7.
    Department of Infectious Microbiology, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str. Bl. 26, 1113, Sofia, Bulgaria.
    Many Geum species are known to be rich in biologically active compounds and therefore could be a source of new natural products with pharmacological potential. The medicinal plant Geum urbanum L. is widespread in Bulgaria and has been used in folk medicine. Read More

    Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3',4':4,5]thieno[2,3-d]pyrimidine derivatives.
    Chem Cent J 2017 Nov 2;11(1):112. Epub 2017 Nov 2.
    Department of Chemistry, Faculty of Science, Arish University, Arish, 45511, Egypt.
    Background: Some novel substituted pyrazolone, pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidinone, thieno[3,2-c]pyrazole and pyrazolo[3',4':4,5]thieno[2,3-d]pyrimidine derivatives have been reported to possess various pharmacological activities like antimicrobial, antitumor and anti-inflammatory.

    Results: A novel series of azoles and azines were designed and prepared via reaction of 1,3-diphenyl-1H-pyrazol-5(4H)-one with some electrophilic and nucleophilic reagents. The structures of target compounds were confirmed by elemental analyses and spectral data. Read More

    Aromatherapy: composition of the gaseous phase at equilibrium with liquid bergamot essential oil.
    Chem Cent J 2017 Nov 2;11(1):111. Epub 2017 Nov 2.
    Dipartimento di Farmacia e Scienze della Salute e della Nutrizione, Università della Calabria, Edificio Polifunzionale, 87036, Arcavacata di Rende, CS, Italy.
    This work compares the composition at different temperatures of gaseous phase of bergamot essential oil at equilibrium with the liquid phase. A new GC-MS methodology to determine quantitatively the volatile aroma compounds was developed. The adopted methodology involved the direct injection of headspace gas into injection port of GC-MS system and of known amounts of the corresponding authentic volatile compounds. Read More

    Bis-pyrimidine acetamides: design, synthesis and biological evaluation.
    Chem Cent J 2017 Aug 8;11(1):80. Epub 2017 Aug 8.
    Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India.
    Background: In the past few years, increased resistance of microorganisms towards antimicrobial agents become a serious health problem, so there is a need for the discovery of new antimicrobial agents. On the other hand, bis-pyrimidines possess various types of biological activity. In view of this, in the present study we have designed and synthesized a new series of bis-pyrimidine acetamides by Claisen-Schmidt condensation and screened for its in vitro antimicrobial and anticancer activities. Read More

    Synthesis and anticancer activity of novel quinazolinone-based rhodanines.
    Chem Cent J 2017 Oct 13;11(1):102. Epub 2017 Oct 13.
    Laboratory of Cell Proliferation and Ageing, Institute of Biosciences and Applications, National Centre of Scientific Research "Demokritos", Athens, Greece.
    Background: Rhodanines and quinazolinones have been reported to possess various pharmacological activities.

    Results: A novel series of twenty quinazolinone-based rhodanines were synthesized via Knoevenagel condensation between 4-[3-(substitutedphenyl)-3,4-dihydro-4-oxoquinazolin-2-yl)methoxy]substituted-benzaldehydes and rhodanine. Elemental and spectral analysis were used to confirm structures of the newly synthesized compounds. Read More

    Phenolic compounds, flavonoids, lipids and antioxidant potential of apricot (Prunus armeniaca L.) pomace fermented by two filamentous fungal strains in solid state system.
    Chem Cent J 2017 Sep 21;11(1):92. Epub 2017 Sep 21.
    Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Cluj-Napoca, Romania.
    Background: The use of agricultural and food by-products is an economical solution to industrial biotechnology. The apricot press residues are abounding by-products from juice industry which can be used as substrates in solid state fermentation process (SSF), thus allowing a liberation and increase of content from various biomolecules with high added value.

    Methods: The evolutions of phenolic levels (by colorimetric assays and high performance liquid chromatography, HPLC-MS) and antioxidant activities (by DPPH assay) during SSF of apricot pomaces with Aspergillus niger and Rhizopus oligosporus were investigated. Read More

    Characterization and quantification of flavonoids and saponins in adzuki bean (Vigna angularis L.) by HPLC-DAD-ESI-MS(n) analysis.
    Chem Cent J 2017 Sep 22;11(1):93. Epub 2017 Sep 22.
    Food Science and Technology Program, Beijing Normal University-Hong Kong Baptist University United International College, 28, Jinfeng Road, Tangjiawan, Zhuhai, 519085, Guangdong, China.
    Background: Bioactive activities of adzuki bean have been widely reported, however, the phytochemical information of adzuki bean is incomplete. The aim of this study was to characterize and quantify flavonoids and saponins in adzuki bean. High performance liquid chromatography with diode array detection and electro spray ionization-tandem multi-stage mass spectrometry (HPLC-DAD-ESI-MS(n)) were applied to do qualitative and quantitative analyses. Read More

    Antioxidant and antiproliferative activity of blue corn and tortilla from native maize.
    Chem Cent J 2017 Oct 30;11(1):110. Epub 2017 Oct 30.
    Instituto de Ciencias Básicas, Universidad Veracruzana, Av. Dr. Luis Castelazo Ayala s/n Col. Industrial Ánimas, 91190, Xalapa, Veracruz, Mexico.
    Background: Blue corn is a cereal rich in phenolic compounds used to make blue tortillas. Tortillas are an important part of the Mexican diet. Blue corn and tortilla represent an important source of the natural antioxidants anthocyanins. Read More

    Antimicrobial activity of thiophene derivatives derived from ethyl (E)-5-(3-(dimethylamino)acryloyl)-4-methyl-2-(phenylamino)thiophene-3-carboxylate.
    Chem Cent J 2017 Aug 3;11(1):75. Epub 2017 Aug 3.
    Departmentof Chemistry, The University of Jordan, Amman, 11942, Jordan.
    Background: The thiophene nucleus has been recognized as an important entity in the synthesis of heterocyclic compounds with promising pharmacological characteristics.

    Results: A number of new heterocyclic compounds incorporating thiophene species have been prepared from the titled enaminone via the reaction with different nucleophiles and electrophiles. The structure elucidation of the designed compounds was derived from their spectral information. Read More

    Effects of temperature, time, and solvent ratio on the extraction of phenolic compounds and the anti-radical activity of Clinacanthus nutans Lindau leaves by response surface methodology.
    Chem Cent J 2017 Jun 14;11(1):54. Epub 2017 Jun 14.
    Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
    Background: Clinacanthus nutans Lindau is a well-known plant, native to tropical Asian countries. Reports on this plant that is rich in phenolic compounds have focused on its therapeutic anti-inflammatory, anti-herpes simplex, antioxidant, and anti-cancer characteristics. In this paper, the influence of the extraction parameters-temperatures (60-80 °C), times (80-120 min), and solvent ratios (70:30-90:10) of water:ethanol were investigated using response surface methodology in order to determine the optimum extraction conditions that could produce maximum extraction yields of the phenolic compounds and the highest anti-radical activity of the C. Read More

    The mechanism for enhanced oxidation degradation of dioxin-like PCBs (PCB-77) in the atmosphere by the solvation effect.
    Chem Cent J 2017 Jul 11;11(1):61. Epub 2017 Jul 11.
    College of Environmental Science and Engineering, North China Electric Power University, No. 2, Beinong Road, Beijing, 102206, China.
    The reaction pathways of PCB-77 in the atmosphere with ·OH, O2, NO x , and (1)O2 were inferred based on density functional theory calculations with the 6-31G* basis set. The structures the reactants, transition states, intermediates, and products were optimized. The energy barriers and reaction heats were obtained to determine the energetically favorable reaction pathways. Read More

    Modification and comparison of three Gracilaria spp. agarose with methylation for promotion of its gelling properties.
    Chem Cent J 2017 Oct 16;11(1):104. Epub 2017 Oct 16.
    Department of Biology, Guangdong Provincial Key Laboratory of Marine Biotechnology, STU-UNIVPM Joint Algal Research Center, College of Science, Shantou University, Shantou, 515063, Guangdong, PR China.
    In order to improve the gelling properties of agarose, we modified it by methylation. The agarose was prepared from Gracilaria asiatica, G. bailinae, and G. Read More

    Synthesis and biological activity of myricetin derivatives containing 1,3,4-thiadiazole scaffold.
    Chem Cent J 2017 Oct 17;11(1):106. Epub 2017 Oct 17.
    State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, 550025, China.
    Background: Myricetin and 1,3,4-thiadiazole derivatives were reported to exhibit favorable antiviral and antibacterial activities. Aiming to discover novel myricetin analogues with potent activities, a series of novel myricetin derivatives containing 1,3,4-thiadiazole moiety were synthesized, and their antibacterial and antiviral activities were evaluated.

    Result: Bioassay results indicated that some target compounds exhibited potential antibacterial and antiviral activities. Read More

    Two phenolic antioxidants in Suoyang enhance viability of •OH-damaged mesenchymal stem cells: comparison and mechanistic chemistry.
    Chem Cent J 2017 Aug 25;11(1):84. Epub 2017 Aug 25.
    School of Chinese Herbal Medicine, Guangzhou University of Chinese Medicine, Waihuan East Road No. 232, Guangzhou Higher Education Mega Center, Guangzhou, 510006, China.
    Background: Suoyang originates from a psammophyte named Cynomorium songaricum Rupr and has been known as a phenolic-antioxidant-enriched traditional Chinese herbal medicine. The present study attempted to investigate the protective effect of phenolic antioxidants in Suoyang towards •OH-mediated MSCs and then further discusses the chemical mechanisms.

    Methods: The lyophilized aqueous extract of Suoyang (LAS) was prepared and characterized using HPLC. Read More

    The development of an effective synthetic route of lesinurad (RDEA594).
    Chem Cent J 2017 Sep 5;11(1):86. Epub 2017 Sep 5.
    Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Culture Road, Jinan, 250012, Shandong, People's Republic of China.
    Background: Lesinurad is a novel selective uric acid salt transport protein 1 (URAT1) inhibitor which is approved in the USA for the treatment of gout. However, there are some shortcomings among the reported synthetic routes, such as expensive materials, environmental pollution and poor yield.

    Results: In this study, an efficient, practical and environmentally-friendly synthetic route of lesinurad is reported. Read More

    Acidic and enzymatic saccharification of waste agricultural biomass for biotechnological production of xylitol.
    Chem Cent J 2017 Oct 2;11(1):97. Epub 2017 Oct 2.
    Industrial Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), 577, Faisalabad, Pakistan.
    Background: The plant biomass and agro-industrial wastes show great potential for their use as attractive low cost substrates in biotechnological processes. Wheat straw and corn cob as hemicellulosic substrates were acid hydrolyzed and enzymatically saccharified for high xylose production. The hydrolysate was concentrated and fermented by using Saccharomyces cerevisiae and Kluyveromyces for production of xylitol. Read More

    Optimization of phenolics and flavonoids extraction conditions of Curcuma Zedoaria leaves using response surface methodology.
    Chem Cent J 2017 Oct 2;11(1):96. Epub 2017 Oct 2.
    Halal Products Research Institute, Universiti Putra Malaysia (UPM), 43400, Serdang, Selangor, Malaysia.
    This study focused on maximizing the extraction yield of total phenolics and flavonoids from Curcuma Zedoaria leaves as a function of time (80-120 min), temperature (60-80 °C) and ethanol concentration (70-90 v/v%). The data were subjected to response surface methodology (RSM) and the results showed that the polynomial equations for all models were significant, did not show lack of fit, and presented adjusted determination coefficients (R(2)) above 99%, proving their suitability for prediction purposes. Using desirability function, the optimum operating conditions to attain a higher extraction of phenolics and flavonoids was found to be 75 °C, 92 min of extraction time and 90:10 of ethanol concentration ratios. Read More

    A review of phytochemistry, metabolite changes, and medicinal uses of the common sunflower seed and sprouts (Helianthus annuus L.).
    Chem Cent J 2017 Sep 29;11(1):95. Epub 2017 Sep 29.
    Department of Food Science and Technology, Faculty of Agro-Industry, Kasetsart University, Bangkok, 10900, Thailand.
    The sunflower (Helianthus annuus L.) seed and sprout is a ubiquitous crop with abundant nutrients and biological activities. This review summarizes the nutritional and medical importance currently recognized but under-researched concerning both seed and sprout highlighting the potential benefits of their phytochemical constituents including phenolic acids, flavonoids and tocopherols. Read More

    Nicotinamide-based diamides derivatives as potential cytotoxic agents: synthesis and biological evaluation.
    Chem Cent J 2017 Oct 24;11(1):109. Epub 2017 Oct 24.
    National Biopesticide Engineering Technology Research Center, Hubei Academy of Agricultural Sciences, Wuhan, 430064, China.
    A series of diamides derivatives containing nicotinamide unit were designed, synthesized and evaluated for their potential cytotoxic activities against human cancer cell lines. All the synthesized compounds were characterized using spectroscopic methods mainly including (1)H NMR, (13)C NMR and MS. The bio-evaluation results indicated that some of the obtained compounds (such as 4d, 4h, 4i) exhibited good to moderate cytotoxic effects on lung cancer cell lines (NCI-H460, A549, and NCI-H1975), especially, compound 4d exhibited the highly potential inhibitory activities against NCI-H460 cell line with the IC50 values of 4. Read More

    Simultaneous determination of cetirizine, phenyl propanolamine and nimesulide using third derivative spectrophotometry and high performance liquid chromatography in pharmaceutical preparations.
    Chem Cent J 2017 Oct 5;11(1):99. Epub 2017 Oct 5.
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, 35516, Egypt.
    Background: The combination between cetirizine (CET), phenylpropanolamine (PPA) and nimesulide (NMS) under trade name Nemeriv Cp tablet is prescribed for nasal congestion, cold, sneezing, and allergy. Among all published methods for the three drugs; there is no reported method concerning estimation of CTZ, PPA and NMS simultaneously and this motivates us to develop new and simple methods for their assay in pure form and tablet preparations.

    Results: Two new methodologies were described for the simultaneous quantification of cetirizine (CTZ), PPA and NMS. Read More

    Steam distillation/drop-by-drop extraction with gas chromatography-mass spectrometry for fast determination of volatile components in jujube (Ziziphus jujuba Mill.) extract.
    Chem Cent J 2017 Oct 13;11(1):101. Epub 2017 Oct 13.
    Center for Chinese Medicine Therapy and Systems Biology, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, Shanghai, China.
    Background: Jujube extract is commonly used as a food additive and flavoring. The unique jujube aroma and the mild sweet aroma of the extract are critical factors that determine product quality and affect consumer acceptability. The aroma changes with changes in the extraction condition, which is typically dependent on the characteristics of volatile oils in the extract. Read More

    Preparative HPLC for large scale isolation, and salting-out assisted liquid-liquid extraction based method for HPLC-DAD determination of khat (Catha edulis Forsk) alkaloids.
    Chem Cent J 2017 Oct 17;11(1):107. Epub 2017 Oct 17.
    Department of Chemistry, Addis Ababa University, P. O. Box 1176, Addis Ababa, Ethiopia.
    Background: Khat (Catha edulis Forsk) is an evergreen shrub of the Celastraceae family. It is widely cultivated in Yemen and East Africa, where its fresh leaves are habitually chewed for their momentary pleasures and stimulation as amphetamine-like effects. The main psychostimulant constituents of khat are the phenylpropylamino alkaloids: cathinone, cathine and norephedrine. Read More

    Surface bound radicals, char yield and particulate size from the burning of tobacco cigarette.
    Chem Cent J 2017 Aug 8;11(1):79. Epub 2017 Aug 8.
    Department of Chemistry, Egerton University, P.O Box 536, Egerton, 20115, Kenya.
    Background: Tobacco smoke is a toxic gas-phase cocktail consisting of a broad range of organics, and free radical intermediates. The formation of smoke from a burning cigarette depends on a series of mechanisms, including generation of products by pyrolysis and combustion, aerosol formation, and physical mass transfer processes.

    Methods: The current study simulates the deposition of particulate matter on the human lung surface by trapping the tobacco smoke particulates in situ on silica gel. Read More

    Reversible uptake of molecular oxygen by heteroligand Co(II)-L-α-amino acid-imidazole systems: equilibrium models at full mass balance.
    Chem Cent J 2017 Sep 19;11(1):90. Epub 2017 Sep 19.
    Department of Physical and Biocoordination Chemistry, Faculty of Pharmacy, Medical University of Łódź, Muszyńskiego 1, 90-151, Lodz, Poland.
    Background: The paper examines Co(II)-amino acid-imidazole systems (where amino acid = L-α-amino acid: alanine, asparagine, histidine) which, when in aqueous solutions, activate and reversibly take up dioxygen, while maintaining the structural scheme of the heme group (imidazole as axial ligand and O2 uptake at the sixth, trans position) thus imitating natural respiratory pigments such as myoglobin and hemoglobin. The oxygenated reaction shows higher reversibility than for Co(II)-amac systems with analogous amino acids without imidazole. Unlike previous investigations of the heteroligand Co(II)-amino acid-imidazole systems, the present study accurately calculates all equilibrium forms present in solution and determines the [Formula: see text]equilibrium constants without using any simplified approximations. Read More

    Isolation, purification, structural analysis and coagulatory activity of water-soluble polysaccharides from Ligustrum lucidum Ait flowers.
    Chem Cent J 2017 Oct 4;11(1):98. Epub 2017 Oct 4.
    Huanghe Science and Technology College, Zhengzhou, 450063, China.
    In this study, Ligustrum lucidum flowers as raw material, the extraction, isolation and coagulatory activity of polysaccharides were carried out for the first time. The crude polysaccharide was obtained by hot water extraction and ethanol precipitation, and preliminarily purified by Sevage method and D101 macroporous resin. Then the polysaccharide was further purified by DEAE-52 cellulose and Sephadex G-100 column chromatography, respectively. Read More

    Formation of amides: one-pot condensation of carboxylic acids and amines mediated by TiCl4.
    Chem Cent J 2017 Sep 15;11(1):87. Epub 2017 Sep 15.
    Dipartimento di Farmacia e Scienze della Salute e della Nutrizione, Università della Calabria Edificio Polifunzionale, 87036, Arcavacata, CS, Italy.
    A general procedure for the synthesis of amides via the direct condensation of carboxylic acids and amines in the presence of TiCl4 is reported. The amidation reaction was performed in pyridine at 85 °C with a wide range of substrates providing the corresponding amide products in moderate to excellent yields and high purity. The reaction proceeds with low yields when both the carboxylic acid and the amine are sterically hindered. Read More

    Novel pyridine-based Pd(II)-complex for efficient Suzuki coupling of aryl halides under microwaves irradiation in water.
    Chem Cent J 2017 Sep 18;11(1):88. Epub 2017 Sep 18.
    Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt.
    Suzuki C-C cross-coupling of aryl halides with aryl boronic acids using new phosphene-free palladium complexes as precatalysts was investigated. A pyridine-based Pd(II)-complex was used in open air under thermal as well as microwave irradiation conditions using water as an eco-friendly green solvent. Read More

    Synthesis and biological evaluation of tricyclic matrinic derivatives as a class of novel anti-HCV agents.
    Chem Cent J 2017 Sep 29;11(1):94. Epub 2017 Sep 29.
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
    Background: 12N-benzyl matrinic acid analogues had been identified to be a novel scaffold of anti-HCV agents with a specific mechanism, and the representative compound 1 demonstrated a moderate anti-HCV activity. The intensive structure-activity relationship of this kind of compounds is explored so as to obtain anti-HCV candidates with good druglike nature.

    Results: Taking compound 1 as the lead, 32 compounds (of which 27 were novel) with diverse structures on the 11-side chain, including methyl matrinate, matrinol, matrinic butane, (Z)-methyl Δ(βγ)-matrinic crotonate derivatives were synthesized and evaluated for their anti-HCV activities. Read More

    A facile access and evaluation of some novel thiazole and 1,3,4-thiadiazole derivatives incorporating thiazole moiety as potent anticancer agents.
    Chem Cent J 2017 Oct 16;11(1):105. Epub 2017 Oct 16.
    Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia.
    Background: Many heterocyclic compounds containing thiazole or 1,3,4-thiadiazole ring in their skeletons have been reported to possess various pharmacological activities especially anticancer activities.

    Results: 4-Methyl-2-phenylthiazole-5-carbohydrazide (2) was used as a synthon to prepare 2-(4-methyl-2-phenylthiazole-5-carbonyl)-N-phenylhydrazinecarbothioamide (3) and 2-(2-(4-methyl-2-phenylthiazole-5-carbonyl)hydrazono)-N'-phenylpropane hydrazonoyl chlorides 5a-c. In addition, thioamide 3 was used as starting material for preparation of a new series of thiadiazole derivatives via its reaction with hydrazonoyl chlorides 5a-c in dioxane using triethylamines as catalyst. Read More

    Synthesis, characterization, anti-ulcer action and molecular docking evaluation of novel benzimidazole-pyrazole hybrids.
    Chem Cent J 2017 Sep 2;11(1):85. Epub 2017 Sep 2.
    Department of Pharmaceutical Chemistry, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan.
    A series of six novel benzimidazole-pyrazole hybrid molecules was synthesized and characterized using elemental analysis (CHN) and spectroscopic methods ((1)HNMR, FT-IR). All the synthesized compounds were evaluated for their in vivo anti ulcerogenic activity using Albino rats (weighing 180-220 g). The interactions between the compounds and active site residues of H(+)/K(+) ATPase were investigated by molecular docking studies using autodock vina 4. Read More

    Synthesis, molecular docking and biological evaluation of bis-pyrimidine Schiff base derivatives.
    Chem Cent J 2017 Sep 18;11(1):89. Epub 2017 Sep 18.
    Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India.
    Background: Heterocyclic pyrimidine nucleus, which is an essential base component of the genetic material of deoxyribonucleic acid, demonstrated various biological activities. A series of bis-pyrimidine Schiff bases were synthesized and screened for its antimicrobial and anticancer potentials. The molecular docking study was carried to find the interaction between active molecules with receptor. Read More

    Synthesis, crystallographic characterization, molecular docking and biological activity of isoquinoline derivatives.
    Chem Cent J 2017 Oct 16;11(1):103. Epub 2017 Oct 16.
    Department of Pharmacology , National Research Centre, El-Bohoth St., Dokki, Cairo, 12622, Egypt.
    The main objective of this work was to synthesize novel compounds with a benzo[de][1,2,4]triazolo[5,1-a]isoquinoline scaffold by employing (dioxo-benzo[de]isoquinolin-2-yl) thiourea as a building block. Molecular docking was conducted in the COX-2 active site to predict the plausible binding mode and rationalize the structure-activity relationship of the synthesized compounds. The structures of the synthesized compounds were confirmed by HREI-MS, and NMR spectra along with X-ray diffraction were collected for products 1 and 5. Read More

    MOF the beaten track: unusual structures and uncommon applications of metal-organic frameworks.
    Chem Cent J 2017 Oct 11;11(1):100. Epub 2017 Oct 11.
    School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, UK.
    Over the past few decades, metal-organic frameworks (MOFs) have proved themselves as strong contenders in the world of porous materials, standing alongside established classes of compounds such as zeolites and activated carbons. Following extensive investigation into the porosity of these materials and their gas uptake properties, the MOF community are now branching away from these heavily researched areas, and venturing into unexplored avenues. Ranging from novel synthetic routes to post-synthetic functionalisation of frameworks, host-guest properties to sensing abilities, this review takes a sidestep away from increasingly 'traditional' approaches in the field, and details some of the more curious qualities of this relatively young family of materials. Read More

    Directed Assembly Network phase three launch: a round-up of success to date and strategy for the future.
    Chem Cent J 2017 Aug 4;11(1):77. Epub 2017 Aug 4.
    School of Aerospace, Transport and Manufacturing (SATM), Cranfield University, Cranfield, MK43 0AL, UK.
    To showcase the Networks' success during phase two (2012-2016), and to set out the strategy for phase three (2017-2019), the Directed Assembly Network held a meeting at the Royal Society in London, United Kingdom on 14 and 15 December 2016. Seventy Network members from both industry and academia attended the event. The meeting, which was used as a springboard to launch and distribute the Networks' 2017 Roadmap to Innovation, comprised of invited talks, an advisory committee meeting, a panel Q & A session and networking. Read More

    Comprehensive spectral identification of key intermediates to the final product of the chiral pool synthesis of radezolid.
    Chem Cent J 2017 Aug 9;11(1):82. Epub 2017 Aug 9.
    Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznan, Poland.
    Radezolid (RAD, 12), biaryl oxazolidinone, was synthesised with small modifications according to the methods described in the literature. The pharmacological activity is observed only for (S)-enantiomer, therefore its synthesis is oriented towards obtaining a single isomer of required purity and desired optical configuration. The intermediate products of RAD synthesis were characterised using (1)H- and (13)C-NMR, as well as the 2D correlation HSQC and HMBC (2, 5, 9, 10), furthermore studied using infrared radiation (FT-IR), Raman scattering (3, 5, 9), and electronic circular dichroism (ECD) (5, 12) spectroscopy. Read More

    Fingerprint analysis of Resina Draconis by ultra-performance liquid chromatography.
    Chem Cent J 2017 Jul 24;11(1):67. Epub 2017 Jul 24.
    School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong Special Administrative Region, People's Republic of China.
    Background: Resina Draconis, a bright red resin derived from Dracaena cochinchinensis, is a traditional medicine used in China. To improve its quality control approach, an ultra-performance liquid chromatography (UPLC) fingerprint method was developed for rapidly evaluating the quality of Resina Draconis.

    Methods: The precision, repeatability and stability of the proposed UPLC method were validated in the study. Read More

    Structural optimization and evaluation of novel 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole derivatives as potential VEGFR-2/PDGFRβ inhibitors.
    Chem Cent J 2017 Aug 1;11(1):72. Epub 2017 Aug 1.
    Graduate Institute of Medical Sciences, National Defense Medical Center, No. 161, Section 6, Mingchuan East Road, Taipei, 11490, Taiwan.
    Background: Tumor angiogenesis, essential for tumor growth and metastasis, is tightly regulated by VEGF/VEGFR and PDGF/PDGFR pathways, and therefore blocking those pathways is a promising therapeutic target. Compared to sunitinib, the C(5)-Br derivative of 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole has significantly greater in vitro activities against VEGFR-2, PDGFRβ, and tube formation.

    Results And Discussion: The objective of this study was to perform further structural optimization, which revealed certain new products with even more potent anti-tumor activities, both cellularly and enzymatically. Read More

    A comparative study of the metal binding behavior of alanine based bis-thiourea isomers.
    Chem Cent J 2017 Aug 4;11(1):76. Epub 2017 Aug 4.
    School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM, Bangi, Selangor, Malaysia.
    Two new symmetrical bis-thiourea, 2,2'-[{(terephthaloylbis(azanediyl)bis(carbonothioyl) bis(azanediyl)}dipropanoic acid] (1A) and 3,3'-[{(terephthaloylbis(azanediyl)bis (carbonothioyl)bis(azanediyl)} dipropanoic acid] (1B) were synthesized by the reaction of terephthaloyl chloride with α- and β-alanine in good yields. Their binding properties were investigated with various metal cations using UV-Vis titration experiments. Both isomers exhibited effective binding with Ag(+), Cu(2+), Hg(2+), Pb(2+), Fe(2+) and Fe(3+) cations. Read More

    One-step multicomponent synthesis of chiral oxazolinyl-zinc complexes.
    Chem Cent J 2017 Aug 9;11(1):81. Epub 2017 Aug 9.
    Department of Chemistry, Imperial College London, Exhibition Road, South Kensington, London, SW7 2AZ, UK.
    Background: Typically, oxazolinyl metal complexes are synthesized in two steps, where the free ligand is prepared by the condensation reaction between a functionalized nitrile and an amino alcohol in the presence of a Lewis or Brønsted acid catalyst, followed by a further reaction with metal salts to obtain the corresponding metal complexes. Very often, the yield afforded by the two-step procedure is not high, and very few oxazolinyl zinc complexes have been prepared by this route. Given that metal-oxazoline complexes often contain Lewis acidic metals, it is conceivable that the two steps may be telescoped. Read More

    Using crystallography, topology and graph set analysis for the description of the hydrogen bond network of triamterene: a rational approach to solid form selection.
    Chem Cent J 2017 Jul 13;11(1):63. Epub 2017 Jul 13.
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
    This study has demonstrated the use of crystallography, topology and graph set analysis in the description and classification of the complex hydrogen bonded network of triamterene. The aim is to give a brief overview of the methodology used to discuss the crystal structure of triamterene with a view to extending the study to include the solvates, cocrystals and salts of this compound. Graphical abstract One of the structurally significant dimers (supramolecular synthons) of triamterene identified by this study. Read More

    Ultra-high resolution X-ray structures of two forms of human recombinant insulin at 100 K.
    Chem Cent J 2017 Aug 1;11(1):73. Epub 2017 Aug 1.
    Department of Crystallography, Biochemical Sciences, Birkbeck College, Malet St, London, WC1E7HX, UK.
    The crystal structure of a commercially available form of human recombinant (HR) insulin, Insugen (I), used in the treatment of diabetes has been determined to 0.92 Å resolution using low temperature, 100 K, synchrotron X-ray data collected at 16,000 keV (λ = 0.77 Å). Read More

    A validated stability-indicating HPLC method for determination of brimonidine tartrate in BRI/PHEMA drug delivery systems.
    Chem Cent J 2017 Jul 11;11(1):62. Epub 2017 Jul 11.
    Department of Pharmacy, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, 200031, China.
    Background: A simple, rapid and accurate stability-indicating reverse phase high performance liquid chromatography (RP-HPLC) was developed and validated for the determination of brimonidine tartrate in brimonidine tartrate/poly(2-hydroxyethyl methacrylate) (BRI/PHEMA) drug delivery contact lenses and pharmaceutical formulations.

    Results: Optimum chromatographic conditions for separating brimonidine tartrate from other impurities in the leaching liquor of BRI/PHEMA drug delivery contact lenses or pharmaceutical formulations have been achieved by using a Diamonsil C18 column (150 mm × 4.6 mm, 5 μm) as a stationary phase and a mixture solution of phosphate buffer (10 mM, pH3. Read More

    Design, synthesis and antimicrobial evaluation of pyrimidin-2-ol/thiol/amine analogues.
    Chem Cent J 2017 Jun 9;11(1):52. Epub 2017 Jun 9.
    Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, 124001, India.
    Background: Pyrimidine is an aromatic heterocyclic moiety containing nitrogen atom at 1st and 3rd positions and play an important role to forms the central core for different necessity of biological active compounds, from this facts, we have designed and synthesized a new class of pyrimidin-2-ol/thiol/amine derivatives and screened for its in vitro antimicrobial activity.

    Results And Discussion: The synthesized pyrimidine derivatives were confirmed by IR, (1)H/(13)C-NMR, Mass spectral studies and evaluated for their in vitro antimicrobial potential against Gram positive (S. aureus and B. Read More

    Comparison of various techniques for the extraction of umbelliferone and herniarin in Matricaria chamomilla processing fractions.
    Chem Cent J 2017 Aug 5;11(1):78. Epub 2017 Aug 5.
    Faculty of Food Technology Osijek, Josip Juraj Strossmayer University of Osijek, Franje Kuhaca 20, 31000, Osijek, Croatia.
    Chamomile, a well-known medicinal plant, is a rich source of bioactive compounds, among which two coumarin derivatives, umbelliferone and herniarin, are often found in its extracts. Chamomile extracts have found a different uses in cosmetic industry, as well as umbelliferone itself, which is, due to its strong absorption of UV light, usually added to sunscreens, while herniarin (7-methoxycoumarin) is also known for its biological activity. Therefore, chamomile extracts with certain herniarin and umbelliferone content could be of interest for application in pharmaceutical and cosmetic products. Read More

    Comparative study of phenolic compounds, vitamin E, and fatty acids compositional profiles in black seed-coated soybeans (Glycine Max (L.) Merrill) depending on pickling period in brewed vinegar.
    Chem Cent J 2017 Jul 18;11(1):64. Epub 2017 Jul 18.
    Department of Crop Science, College of Sanghuh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.
    Background: Pickled soybeans or vinegar beans have long been used as a folk remedy and also a supplemental nutritional source in Korea. In general the pickling process in vinegar improves the digestibility of soybeans as well as increases the availability of various (non-)nutrients in soybeans. However, detailed information about the changes in functional substances such as (poly)phenolic compounds, vitamin E, and fatty acids (FAs) in soybeans during the pickling process is quite limited. Read More

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