1,052 results match your criteria Chemistry Central Journal [Journal]


Microwave synthesis, crystal structure, antioxidant, and antimicrobial study of new 6-heptyl-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline compound.

Chem Cent J 2018 Dec 20;12(1):145. Epub 2018 Dec 20.

Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

Background: Although the development of antibiotic and antioxidant manufacturing, the problem of bacterial resistance and food and/or cosmetics oxidation still needs more efforts to design new derivatives which can help to minimize these troubles. Benzimidazo[1,2-c]quinazolines are nitrogen-rich heterocyclic compounds that possess many pharmaceutical properties such as antimicrobial, anticonvulsant, immunoenhancer, and anticancer.

Results: A comparative study between two methods, (microwave-assisted and conventional heating approaches), was performed to synthesise a new quinazoline derivative from 2-(2-aminophenyl)-1H-benzimidazole and octanal to produce 6-heptyl-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline (OCT). Read More

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http://dx.doi.org/10.1186/s13065-018-0509-zDOI Listing
December 2018
6 Reads

Determination of antioxidant and antimicrobial activities of the extracts of aerial parts of Portulaca quadrifida.

Chem Cent J 2018 Dec 20;12(1):146. Epub 2018 Dec 20.

Agricultural and Nutritional Research Laboratory, Ethiopian Institute of Agricultural Research (EIAR), P.O Box 2003, Addis Ababa, Ethiopia.

Background: The extracts from the aerial parts of Portulaca quadrifida have been reported to show the total flavonoid content, antioxidant and antibacterial activities.

Results: Our results revealed that the total flavonoid content of methanol and chloroform extracts is 2.335 ± 0. Read More

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http://dx.doi.org/10.1186/s13065-018-0514-2DOI Listing
December 2018
1 Read

Design, synthesis and therapeutic potential of 3-(2-(1H-benzo[d]imidazol-2-ylthio)acetamido)-N-(substituted phenyl)benzamide analogues.

Chem Cent J 2018 Dec 19;12(1):139. Epub 2018 Dec 19.

Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India.

Background: The emergence of bacterial resistance is a major public health problem. It is essential to develop and synthesize new therapeutic agents with better activity. The mode of actions of certain newly developed antimicrobial agents, however, exhibited very limited effect in treating life threatening systemic infections. Read More

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https://ccj.springeropen.com/articles/10.1186/s13065-018-051
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http://dx.doi.org/10.1186/s13065-018-0513-3DOI Listing
December 2018
7 Reads

Analysis of coumarin and angelica lactones in smokeless tobacco products.

Chem Cent J 2018 Dec 20;12(1):142. Epub 2018 Dec 20.

Department of Medicine, School of Medicine, University of Louisville, Room 208, 505 South Hancock Street, Louisville, KY, 40202, USA.

Differences in health risks between different styles of smokeless tobacco products (STPs) have prompted interest in their relative levels of toxic chemicals. We report here the development of methods for the analysis of STPs for coumarin and for α-angelica lactone (α-AL), both of which have been included in various published lists of tobacco toxicants. We have also determined the concentrations of these lactones in commercial STPs from the US and Sweden, representing 80-90% of the 2010 market share for all the major STP categories in these two countries: 65 products (plus two reference products) for coumarin and 66 commercial products for α-AL. Read More

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https://ccj.springeropen.com/articles/10.1186/s13065-018-050
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http://dx.doi.org/10.1186/s13065-018-0506-2DOI Listing
December 2018
7 Reads

Novel glitazones as PPARγ agonists: molecular design, synthesis, glucose uptake activity and 3D QSAR studies.

Chem Cent J 2018 Dec 19;12(1):141. Epub 2018 Dec 19.

Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, 570 015, India.

Background: An alarming requirement for finding newer antidiabetic glitazones as agonists to PPARγ are on its utmost need from past few years as the side effects associated with the available drug therapy is dreadful. In this context, herein, we have made an attempt to develop some novel glitazones as PPARγ agonists, by rational and computer aided drug design approach by implementing the principles of bioisosterism. The designed glitazones are scored for similarity with the developed 3D pharmacophore model and subjected for docking studies against PPARγ proteins. Read More

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http://dx.doi.org/10.1186/s13065-018-0508-0DOI Listing
December 2018
1 Read
2.187 Impact Factor

Development of a practical synthesis of etravirine via a microwave-promoted amination.

Chem Cent J 2018 Dec 20;12(1):144. Epub 2018 Dec 20.

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Ji'nan, 250012, Shandong, People's Republic of China.

Background: Etravirine (ETV) was approved as the second generation drug for use in individuals infected with HIV-1 in 2008 by the U.S. FDA with its unique antiviral activity, high specificity, and low toxicity. Read More

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https://ccj.springeropen.com/articles/10.1186/s13065-018-050
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http://dx.doi.org/10.1186/s13065-018-0504-4DOI Listing
December 2018
12 Reads

Ligand exchange method for determination of mole ratios of relatively weak metal complexes: a comparative study.

Chem Cent J 2018 Dec 20;12(1):143. Epub 2018 Dec 20.

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, 31111, Egypt.

Ligand exchange method is introduced as an alternative to Job's and mole ratio methods for studying the stoichiometry of relatively weak metal complexes in solutions. The method involves adding varying amounts of a ligand (L) to an excess constant amount of a colored complex (MX) with appropriate stability and molar absorptivity. The absorbance of each solution is measured at the λ of the initial complex, MX, and plotted against the concentration of the studied ligand, L. Read More

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http://dx.doi.org/10.1186/s13065-018-0512-4DOI Listing
December 2018
1 Read

Synthesis, biological evaluation and molecular docking studies of 6-(4-nitrophenoxy)-1H-imidazo[4,5-b]pyridine derivatives as novel antitubercular agents: future DprE1 inhibitors.

Chem Cent J 2018 Dec 19;12(1):138. Epub 2018 Dec 19.

Department of Pharmaceutical Chemistry, School of Pharmacy & Technology Management, SVKM's NMIMS, Shirpur Campus, Dhule, 425 405, India.

Tuberculosis is an air-borne disease, mostly affecting young adults in their productive years. Here, Ligand-based drug design approach yielded a series of 23 novel 6-(4-nitrophenoxy)-1H-imidazo[4,5-b]pyridine derivatives. The required building block of imidazopyridine was synthesized from commercially available 5,5-diaminopyridine-3-ol followed by four step sequence. Read More

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http://dx.doi.org/10.1186/s13065-018-0515-1DOI Listing
December 2018
1 Read

Classification of different pineapple varieties grown in Malaysia based on volatile fingerprinting and sensory analysis.

Chem Cent J 2018 Dec 19;12(1):140. Epub 2018 Dec 19.

Department of Food Technology, University Putra Malaysia, 43400 UPM, Serdang, Malaysia.

Background: Pineapple is highly relished for its attractive sweet flavour and it is widely consumed in both fresh and canned forms. Pineapple flavour is a blend of a number of volatile and non-volatile compounds that are present in small amounts and in complex mixtures. The aroma compounds composition may be used for purposes of quality control as well as for authentication and classification of pineapple varieties. Read More

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http://dx.doi.org/10.1186/s13065-018-0505-3DOI Listing
December 2018
2 Reads

Therapeutic importance of synthetic thiophene.

Chem Cent J 2018 Dec 19;12(1):137. Epub 2018 Dec 19.

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, 124001, India.

Thiophene and its substituted derivatives are very important class of heterocyclic compounds which shows interesting applications in the field of medicinal chemistry. It has made an indispensable anchor for medicinal chemists to produce combinatorial library and carry out exhaustive efforts in the search of lead molecules. It has been reported to possess a wide range of therapeutic properties with diverse applications in medicinal chemistry and material science, attracting great interest in industry as well as academia. Read More

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http://dx.doi.org/10.1186/s13065-018-0511-5DOI Listing
December 2018
1 Read

Palladium-catalyzed borylation of aryl (pseudo)halides and its applications in biaryl synthesis.

Chem Cent J 2018 Dec 19;12(1):136. Epub 2018 Dec 19.

School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, 999077, Hong Kong Special Administrative Region, People's Republic of China.

A facile and efficient palladium-catalyzed borylation of aryl (pseudo)halides at room temperature has been developed. Arylboronic esters were expeditiously assembled in good yields and with a broad substrate scope and good functional group compatibility. This approach has been successfully applied to the one-pot two-step borylation/Suzuki-Miyaura cross-coupling reaction, providing a concise access to biaryl compounds from readily available aryl halides. Read More

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http://dx.doi.org/10.1186/s13065-018-0510-6DOI Listing
December 2018
2 Reads

Chemical composition, antioxidant and antimicrobial potential of essential oils from different parts of Daphne mucronata Royle.

Chem Cent J 2018 Dec 17;12(1):135. Epub 2018 Dec 17.

Department of Crop Science, Faculty of Agriculture, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

This research work was executed to determine chemical composition, anti-oxidant and anti-microbial potential of the essential oils extracted from the leaves and stem of Daphne mucronata Royle. From leaves and stem oils fifty-one different constituents were identified through GC/MS examination. The antioxidant potential evaluated through DPPH free radical scavenging activity and %-inhibition of peroxidation in linoleic acid system. Read More

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http://dx.doi.org/10.1186/s13065-018-0495-1DOI Listing
December 2018
1 Read

Preparation, optimization and swelling study of carboxymethyl sago starch (CMSS)-acid hydrogel.

Chem Cent J 2018 Dec 6;12(1):133. Epub 2018 Dec 6.

Laboratory of Vaccine and Immunotherapeutic, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

In this study, sago starch was modified in order to enhance its physicochemical properties. Carboxymethylation was used to introduce a carboxymethyl group into a starch compound. The carboxymethyl sago starch (CMSS) was used to prepare smart hydrogel by adding acetic acid into the CMSS powder as the crosslinking agent. Read More

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http://dx.doi.org/10.1186/s13065-018-0500-8DOI Listing
December 2018
1 Read

Synthesis, characterization, molecular docking, analgesic, antiplatelet and anticoagulant effects of dibenzylidene ketone derivatives.

Chem Cent J 2018 Dec 6;12(1):134. Epub 2018 Dec 6.

Basic Sciences Department, College of Science and Health Professions-(COSHP-J), King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.

In this study dibenzylidene ketone derivatives (2E,5E)-2-(4-methoxybenzylidene)-5-(4-nitrobenzylidene) cyclopentanone (AK-1a) and (1E,4E)-4-(4-nitrobenzylidene)-1-(4-nitrophenyl) oct-1-en-3-one (AK-2a) were newly synthesized, inspired from curcuminoids natural origin. Novel scheme was used for synthesis of AK-1a and AK-2a. The synthesized compounds were characterized by spectroscopic techniques. Read More

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http://dx.doi.org/10.1186/s13065-018-0507-1DOI Listing
December 2018
3 Reads

Sodium dichloroisocyanurate delays ripening and senescence of banana fruit during storage.

Chem Cent J 2018 Dec 5;12(1):131. Epub 2018 Dec 5.

Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, People's Republic of China.

Banana as a typical climacteric fruit soften rapidly, resulting in a very short shelf life after harvest. Sodium dichloroisocyanurate (NaDCC) is reported to be an effectively antibacterial compound. Here, we investigated the effects of NaDCC on ripening and senescence of harvested banana fruit at physiological and molecular levels. Read More

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http://dx.doi.org/10.1186/s13065-018-0503-5DOI Listing
December 2018
2 Reads

A modified method of separating Tl(I) and Tl(III) in aqueous samples using solid phase extraction.

Chem Cent J 2018 Dec 5;12(1):132. Epub 2018 Dec 5.

UMR Ecosys, Université Paris-Saclay, AgroParisTech, Avenue Lucien Brétignières, 78850, Thiverval-Grignon, France.

In spite of the development of new measurement techniques in recent years, the rapid and accurate speciation of thallium in environmental aqueous samples remains a challenge. In this context, a novel method of solid phase extraction (SPE), involving the anion exchange resin AG1-X8, is proposed to separate Tl(I) and Tl(III). In the presence of diethylene triamine pentacetate acid (DTPA), Tl(III) and Tl(I) can be separated by selective adsorption of Tl(III)-DTPA onto the resin, Tl(III) is then eluted by a solution of HCl with SO. Read More

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http://dx.doi.org/10.1186/s13065-018-0502-6DOI Listing
December 2018
2 Reads

Coagulatory active constituents of Malus pumila Mill. flowers.

Chem Cent J 2018 Dec 3;12(1):126. Epub 2018 Dec 3.

Zhengzhou Key Laboratory of Medicinal Resources Research, Huanghe Science and Technology College, Zhengzhou, 450063, China.

Background: The flowers of Malus pumila Mill (Rosaceae) is rich in resources, but lack of medicinal value research. Chemical constituents of the same family M. pumila have coagulatory activity. Read More

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http://dx.doi.org/10.1186/s13065-018-0490-6DOI Listing
December 2018
1 Read

Synthesis and biological profile of substituted benzimidazoles.

Chem Cent J 2018 Dec 1;12(1):125. Epub 2018 Dec 1.

Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraidah, 51452, Kingdom of Saudi Arabia.

Background: A series of benzimidazole derivatives was developed and its chemical scaffolds were authenticated by NMR, IR, elemental analyses and physicochemical properties. The synthesized compounds were screened for their antimicrobial and antiproliferative activities.

Results And Discussion: The synthesized benzimidazole compounds were evaluated for their antimicrobial activity using the tube dilution method and were found to exhibit good antimicrobial potential against selected Gram negative and positive bacterial and fungal species. Read More

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https://ccj.springeropen.com/articles/10.1186/s13065-018-049
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http://dx.doi.org/10.1186/s13065-018-0498-yDOI Listing
December 2018
13 Reads

Design, synthesis and biological evaluation of 3-(2-aminooxazol-5-yl)-2H-chromen-2-one derivatives.

Chem Cent J 2018 Dec 4;12(1):130. Epub 2018 Dec 4.

Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India.

Background: In view of wide range of biological activities of oxazole, a new series of oxazole analogues was synthesized and its chemical structures were confirmed by spectral data (Proton/Carbon-NMR, IR, MS etc.). The synthesized oxazole derivatives were screened for their antimicrobial and antiproliferative activities. Read More

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https://ccj.springeropen.com/articles/10.1186/s13065-018-049
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http://dx.doi.org/10.1186/s13065-018-0499-xDOI Listing
December 2018
9 Reads

Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/B and β-amyloid inhibitors for Alzheimer's disease.

Chem Cent J 2018 Dec 4;12(1):128. Epub 2018 Dec 4.

Industrial Chemistry Programme, Faculty of Science and Natural Resources, Universiti Malaysia Sabah, 88400, Kota Kinabalu, Sabah, Malaysia.

Coumarins are the phytochemicals, which belong to the family of benzopyrone, that display interesting pharmacological properties. Several natural, synthetic and semisynthetic coumarin derivatives have been discovered in decades for their applicability as lead structures as drugs. Coumarin based conjugates have been described as potential AChE, BuChE, MAO and β-amyloid inhibitors. Read More

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http://dx.doi.org/10.1186/s13065-018-0497-zDOI Listing
December 2018
6 Reads

Synthesis, SAR and in vitro therapeutic potentials of thiazolidine-2,4-diones.

Chem Cent J 2018 Dec 4;12(1):129. Epub 2018 Dec 4.

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India.

Background: Thiazolidinedione is a pentacyclic moiety having five membered unsaturated ring system composed with carbon, oxygen, nitrogen and sulfur molecules at 1 and 3 position of the thiazole ring and widely found throughout nature in various form. They favourably alter concentration of the hormones secreted by adipocytes, particularly adiponectin. They also increase total body fat and have mixed effects on circulating lipids. Read More

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https://ccj.springeropen.com/articles/10.1186/s13065-018-049
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http://dx.doi.org/10.1186/s13065-018-0496-0DOI Listing
December 2018
10 Reads

Temperature dependent control of the solubility of gallium nitride in supercritical ammonia using mixed mineralizer.

Chem Cent J 2018 Dec 3;12(1):127. Epub 2018 Dec 3.

Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, 980-8577, Japan.

Using a mass-loss method, we investigated the solubility change of gallium nitride (GaN) in supercritical ammonia with mixed mineralizers [ammonium chloride (NHCl) + ammonium bromide (NHBr) and NHCl + ammonium iodide (NHI)]. The solubilities were measured over the temperature range 450-550 °C, at 100 MPa. The solubility increased with NHCl mole fraction at 450 °C and 100 MPa. Read More

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https://ccj.springeropen.com/articles/10.1186/s13065-018-050
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http://dx.doi.org/10.1186/s13065-018-0501-7DOI Listing
December 2018
10 Reads

Modeling tool using neural networks for L(+)-lactic acid production by pellet-form Rhizopus oryzae NRRL 395 on biodiesel crude glycerol.

Chem Cent J 2018 Nov 29;12(1):124. Epub 2018 Nov 29.

Department of Environmental and Plant Protection, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Cluj-Napoca, Romania.

Most chemical reactions produce unwanted by-products. In an effort to reduce environmental problems these by-products could be used to produce valuable organic chemicals. In biodiesel industry a huge amount of glycerol is generated, approximately 10% of the final product. Read More

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https://ccj.springeropen.com/articles/10.1186/s13065-018-049
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http://dx.doi.org/10.1186/s13065-018-0491-5DOI Listing
November 2018
2 Reads

Synthesis and antibacterial activity of new 1,2,3-triazolylmethyl-2H-1,4-benzothiazin-3(4H)-one derivatives.

Chem Cent J 2018 Nov 29;12(1):123. Epub 2018 Nov 29.

Laboratoire de Chimie Organique Hétérocyclique, Centre de Recherche des Sciences des Médicaments, Pôle de Compétences Pharmacochimie, Faculté des Sciences, Mohammed V University in Rabat, Av. Ibn Battouta, BP 1014, Rabat, Morocco.

Background: A novel series of 1,2,3-triazole derivatives containing 1,4-benzothiazin-3-one ring (7a-9a, 7b-9b), (10a-12a, 10b-12b) and (13-15) were synthesized by 1,3-dipolar cycloaddition reactions of azides α-D-galactopyranoside azide F, 2,3,4,6-tetra-O-acetyl-(D)-glucopyranosyl azide G and methyl-N-benzoyl-α-azidoglycinate H with compounds 4-6.

Findings: Initially, the reactions were conducted under thermal conditions in ethanol. The reaction leads, each time, to the formation of two regioisomers: (Schemes 2, 3) with yields of 17 to 21% for 1,5-disubstituted 1,2,3-triazole-regioisomers (7b-12b) and yields ranging from 61 to 65% for the 1,4-disubstituted regioisomers (7a-12a). Read More

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http://dx.doi.org/10.1186/s13065-018-0494-2DOI Listing
November 2018
4 Reads
2.187 Impact Factor

Synthesis, crystal structure, DFT studies and biological activity of (Z)-3-(3-bromophenyl)-1-(1,5-dimethyl-1H-pyrazol-3-yl)-3-hydroxyprop-2-en-1-one.

Chem Cent J 2018 Nov 26;12(1):122. Epub 2018 Nov 26.

Laboratoire de Chimie Appliquée et Environnement (LCAE), Faculté des Sciences, Université Mohamed I, 60000, Oujda, Morocco.

Background: Nowadays, is emerging a new generation of highly promising inhibitors bearing the β-ketoenol functionality. The present work relates to the first synthesis, the structure determination, the DFT studies and the use of a new biomolecule designed with a β-ketoenol group bounded to a pyrazolic moiety.

Result: A novel β-ketoenol-pyrazole has been synthesized, well characterized and its structure was confirmed by single crystal X-ray diffraction. Read More

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https://ccj.springeropen.com/articles/10.1186/s13065-018-049
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http://dx.doi.org/10.1186/s13065-018-0492-4DOI Listing
November 2018
9 Reads

Ethylene glycol elimination in amine loop for more efficient gas conditioning.

Chem Cent J 2018 Nov 23;12(1):120. Epub 2018 Nov 23.

Faculty of Chemical and Materials Engineering, Shahrood University of Technology, Shahrood, Iran.

The gas sweetening unit of phase 2 and 3 in South Pars Gas Field (Asalouyeh, Iran) was first simulated to investigate the effect of mono ethylene glycol (MEG) in the amine loop. MEG is commonly injected into the system to avoid hydrate formation while a few amounts of MEG is usually transferred to amine gas sweetening plant. This paper aims to address the points where MEG has negative effects on gas sweetening process and what the practical ways to reduce its effect are. Read More

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http://dx.doi.org/10.1186/s13065-018-0493-3DOI Listing
November 2018
1 Read

An integrated approach towards the development of novel antifungal agents containing thiadiazole: synthesis and a combined similarity search, homology modelling, molecular dynamics and molecular docking study.

Chem Cent J 2018 Nov 23;12(1):121. Epub 2018 Nov 23.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Biruni University, 34010, Istanbul, Turkey.

Background: This study aims to synthesise and characterise novel compounds containing 2-amino-1,3,4-thiadiazole and their acyl derivatives and to investigate antifungal activities. Similarity search, molecular dynamics and molecular docking were also studied to find out a potential target and enlighten the inhibition mechanism.

Results: As a first step, 2-amino-1,3,4-thiadiazole derivatives (compounds 3 and 4) were synthesised with high yields (81 and 84%). Read More

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http://dx.doi.org/10.1186/s13065-018-0485-3DOI Listing
November 2018
10 Reads

Fabrication of 6-gingerol, doxorubicin and alginate hydroxyapatite into a bio-compatible formulation: enhanced anti-proliferative effect on breast and liver cancer cells.

Chem Cent J 2018 Nov 23;12(1):119. Epub 2018 Nov 23.

UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK.

Ample attention has been devoted to the construction of anti-cancer drug delivery systems with increased stability, and controlled and targeted delivery, minimizing toxic effects. In this study we have designed a magnetically attractive hydroxyapatite (m-HAP) based alginate polymer bound nanocarrier to perform targeted, controlled and pH sensitive drug release of 6-gingerol, doxorubicin, and their combination, preferably at low pH environments (pH 5.3). Read More

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http://dx.doi.org/10.1186/s13065-018-0482-6DOI Listing
November 2018
1 Read
2.187 Impact Factor

Novel amphiphilic pyridinium ionic liquids-supported Schiff bases: ultrasound assisted synthesis, molecular docking and anticancer evaluation.

Chem Cent J 2018 Nov 22;12(1):118. Epub 2018 Nov 22.

Department of Chemistry, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah, Medina, 30002, Saudi Arabia.

Background: Pyridinium Schiff bases and ionic liquids have attracted increasing interest in medicinal chemistry.

Results: A library of 32 cationic fluorinated pyridinium hydrazone-based amphiphiles tethering fluorinated counteranions was synthesized by alkylation of 4-fluoropyridine hydrazone with various long alkyl iodide exploiting lead quaternization and metathesis strategies. All compounds were assessed for their anticancer inhibition activity towards different cancer cell lines and the results revealed that increasing the length of the hydrophobic chain of the synthesized analogues appears to significantly enhance their anticancer activities. Read More

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http://dx.doi.org/10.1186/s13065-018-0489-zDOI Listing
November 2018
11 Reads

Synthesis, biological evaluation and corrosion inhibition studies of transition metal complexes of Schiff base.

Chem Cent J 2018 Nov 20;12(1):117. Epub 2018 Nov 20.

Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India.

Background: The transition metal complexes formed from Schiff base is regarded as leading molecules in medicinal chemistry. Because of the preparative availability and diversity in the structure of central group, the transition metals are important in coordination chemistry. In the present work, we have designed and prepared Schiff base and its metal complexes (MC-MC) and screened them for antimicrobial, anticancer and corrosion inhibitory properties. Read More

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http://dx.doi.org/10.1186/s13065-018-0487-1DOI Listing
November 2018
10 Reads

Simultaneous elimination of Malachite Green, Rhodamine B and Cresol Red from aqueous sample with Sistan sand, optimized by Taguchi L16 and Plackett-Burman experiment design methods.

Chem Cent J 2018 Nov 16;12(1):116. Epub 2018 Nov 16.

Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Science, Zahedan, Iran.

The purpose of this study was to investigate the feasibility of simultaneous optimization and removal of dyes, Malachite green (MG), Rhodamine B (RhB) and Cresol Red (CR) from aqueous solutions by using Sistan sand as an extremely low cost adsorbent. Factors affecting adsorption of the analytes on the sorbent were investigated experimentally and by using Taguchi and Plackett-Burman experimental design methods. In most cases, the results of these two models were in agreement with each other and with experimental data obtained. Read More

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http://dx.doi.org/10.1186/s13065-018-0486-2DOI Listing
November 2018
5 Reads
2.190 Impact Factor

Synthesis and antitumor activities of 3-substituted-analine derivatives: structure modifications of Tuv part of tubulysins.

Chem Cent J 2018 Nov 15;12(1):115. Epub 2018 Nov 15.

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, People's Republic of China.

Background: Tubulysins family is a kind of natural compound with potent, antitumor activity. To simplify the synthesis route and find new antitumor compounds is becoming a hotspot of research recent years.

Results: Starting from 3-nitrobenzoic acid, after 7 steps transformations, 12 new tubulysin analogues were synthesized by the conformational restraint and bioisostere principle. Read More

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https://ccj.springeropen.com/articles/10.1186/s13065-018-048
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http://dx.doi.org/10.1186/s13065-018-0483-5DOI Listing
November 2018
6 Reads

Green multicomponent synthesis, antimicrobial and antioxidant evaluation of novel 5-amino-isoxazole-4-carbonitriles.

Chem Cent J 2018 Nov 15;12(1):114. Epub 2018 Nov 15.

Young Researchers and Elite Club, Kerman Branch, Islamic Azad University, Kerman, Iran.

Background: Design and synthesis of new inhibitor agents to deal with pathogenic microorganisms is expanding. In this project, an efficient, environmentally friendly, economical, rapid and mild procedure was developed for the synthesis of novel functionalized isoxazole derivatives as antimicrobial potentials.

Methods: Multicomponent reaction between malononitrile (1), hydroxylamine hydrochloride (2) and different aryl or heteroaryl aldehydes 3a-i afforded novel 5-amino-isoxazole-4-carbonitriles 4a-i in good product yields and short reaction times. Read More

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https://ccj.springeropen.com/articles/10.1186/s13065-018-048
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http://dx.doi.org/10.1186/s13065-018-0488-0DOI Listing
November 2018
7 Reads

Planting and seasonal and circadian evaluation of a thymol-type oil from Lippia thymoides Mart. & Schauer.

Chem Cent J 2018 Nov 12;12(1):113. Epub 2018 Nov 12.

Programa de Pós-Graduação em Química, Universidade Federal do Pará, Belém, PA, 66075-900, Brazil.

Background: The oil and extracts of Lippia thymoides have been used for various medicinal and food applications. Entrepreneurs in the Amazon have been considering the economic exploitation of this plant. The present study evaluated the influence of the seasonal and circadian rhythm on the yield and composition of the essential oil of leaves and thin branches of a Lippia thymoides specimen cultivated in Abaetetuba, State of Pará, Brazil. Read More

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http://dx.doi.org/10.1186/s13065-018-0484-4DOI Listing
November 2018
1 Read

Hybrid caffeic acid derivatives as monoamine oxidases inhibitors: synthesis, radical scavenging activity, molecular docking studies and in silico ADMET analysis.

Chem Cent J 2018 Nov 9;12(1):112. Epub 2018 Nov 9.

Laboratory for Preservation Technology and Enzyme Inhibition Studies, Faculty of Pharmaceutical Sciences, M. D. University, Rohtak, Haryana, 124001, India.

Background: Monoamine oxidase has been implicated in numerous neurological disorders. Although synthetic monoamine oxidase inhibitors (MAOI) have emerged with many side effects, the aspiration of natural based MAOI has greatly increased. As they exhibit fewer side effects and food interaction along with improved neuropharmacological profile. Read More

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https://ccj.springeropen.com/articles/10.1186/s13065-018-048
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http://dx.doi.org/10.1186/s13065-018-0481-7DOI Listing
November 2018
16 Reads

Design, synthesis, ADME prediction and pharmacological evaluation of novel benzimidazole-1,2,3-triazole-sulfonamide hybrids as antimicrobial and antiproliferative agents.

Chem Cent J 2018 Nov 1;12(1):110. Epub 2018 Nov 1.

Department of Chemistry, Faculty of Science, Alexandria University, Alexandria, 21500, Egypt.

Background: Nitrogen heterocyclic rings and sulfonamides have attracted attention of several researchers.

Results: A series of regioselective imidazole-based mono- and bis-1,4-disubstituted-1,2,3-triazole-sulfonamide conjugates 4a-f and 6a-f were designed and synthesized. The first step in the synthesis was a regioselective propargylation in the presence of the appropriate basic catalyst (EtN and/or KCO) to afford the corresponding mono-2 and bis-propargylated imidazoles 5. Read More

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https://ccj.springeropen.com/articles/10.1186/s13065-018-047
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http://dx.doi.org/10.1186/s13065-018-0479-1DOI Listing
November 2018
7 Reads

Design, synthesis and biological activity of hydroxybenzoic acid ester conjugates of phenazine-1-carboxylic acid.

Chem Cent J 2018 Nov 1;12(1):111. Epub 2018 Nov 1.

Hubei Collaborative Innovation Centre for Grain Industry, Yangtze University, Jingmi Road 88, Jingzhou, 434025, China.

We prepared 16 novel hydroxybenzoic acid ester conjugates of phenazine-1-carboxylic acid (PCA) and investigated their biological activity. Most of the synthesized conjugates displayed some level of fungicidal activities in vitro against five phytopathogenic fungi. Nine conjugates 5b, 5c, 5d, 5e, 5h, 5i, 5m, 5n and 5o (EC between 3. Read More

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https://ccj.springeropen.com/articles/10.1186/s13065-018-047
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http://dx.doi.org/10.1186/s13065-018-0478-2DOI Listing
November 2018
2 Reads
2.190 Impact Factor

Isolation of polysaccharides from Dendrobium officinale leaves and anti-inflammatory activity in LPS-stimulated THP-1 cells.

Chem Cent J 2018 Oct 31;12(1):109. Epub 2018 Oct 31.

Department of Biopharmaceutics, College of Food Science and Technology, Shanghai Ocean University, 999 Hucheng Ring Road, Lingang New City, Shanghai, 201306, China.

Dendrobium officinale stem is rich in polysaccharides, which play a great role in the medicinal effects of this plant. However, little was known about the polysaccharides from Dendrobium officinale leaves. Two kinds of polysaccharides in the leaves, DLP-1 and DLP-2, were obtained by hot water extraction, alcohol sedimentation and chromatographic separation (DEAE-52 cellulose column and Sephadex G-100 column). Read More

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https://ccj.springeropen.com/articles/10.1186/s13065-018-048
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http://dx.doi.org/10.1186/s13065-018-0480-8DOI Listing
October 2018
2 Reads

Magnetic core-shell Carrageenan moss/FeO: a polysaccharide-based metallic nanoparticles for synthesis of pyrimidinone derivatives via Biginelli reaction.

Chem Cent J 2018 Oct 27;12(1):108. Epub 2018 Oct 27.

Heterocyclic Chemistry Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran.

Magnetically recoverable polysaccharide-based metallic nanoparticles Carrageenan moss/FeO (FeO@CM) was tested for the synthesis of Pyrimidinone derivatives via Biginelli reaction under reflux conditions in Water. Interestingly, FeO@CM prepared from unmodified Irish moss showed remarkable catalytic activity and recyclability. Low catalyst loading, simple reaction procedure, and using a green catalyst from a natural source are the important merits of this protocol. Read More

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https://ccj.springeropen.com/articles/10.1186/s13065-018-047
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http://dx.doi.org/10.1186/s13065-018-0477-3DOI Listing
October 2018
10 Reads

Estrogen alpha receptor antagonists for the treatment of breast cancer: a review.

Chem Cent J 2018 Oct 25;12(1):107. Epub 2018 Oct 25.

Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, 124001, India.

Background: Cancer is at present one of the leading causes of death in the world. It accounts for 13% of deaths occurred worldwide and is continuously rising, with an estimated million of deaths up to 2030. Due to poor availability of prevention, diagnosis and treatment of breast cancer, the rate of mortality is at alarming level globally. Read More

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https://ccj.springeropen.com/articles/10.1186/s13065-018-047
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http://dx.doi.org/10.1186/s13065-018-0472-8DOI Listing
October 2018
6 Reads

Reverse pharmacophore mapping and molecular docking studies for discovery of GTPase HRas as promising drug target for bis-pyrimidine derivatives.

Chem Cent J 2018 Oct 22;12(1):106. Epub 2018 Oct 22.

Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraidah, 51452, Saudi Arabia.

Background: Pyrimidine is an important pharmacophore in the field of medicinal chemistry and exhibit a broad spectrum of biological potentials. A study was carried out to identify the target protein of potent bis-pyrimidine derivatives using reverse docking program. PharmMapper, a robust online tool was used for identifying the target proteins based on reverse pharmacophore mapping. Read More

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http://dx.doi.org/10.1186/s13065-018-0475-5DOI Listing
October 2018
2 Reads

Chemical composition, antioxidant activity and antibacterial mechanism of action from Marsilea minuta leaf hexane: methanol extract.

Chem Cent J 2018 Oct 20;12(1):105. Epub 2018 Oct 20.

Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, Republic of Korea.

Background: In the present study, hexane: methanol (50:50) leaf extract of Marisela minuta has been evaluated for its chemical composition, antioxidant effect and the antimicrobial mechanism of action against food borne pathogenic bacteria.

Results: The phytochemical evaluation of extract by GC/MS revealed the major abundance of benzoic acid-4-ethoxyethyl ester (43.39%) and farnesol acetate (18. Read More

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https://ccj.springeropen.com/articles/10.1186/s13065-018-047
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http://dx.doi.org/10.1186/s13065-018-0476-4DOI Listing
October 2018
26 Reads

Synthesis and characterization of TiO-VO-MCM-41 for catalyzing transesterification of dimethyl carbonate with phenol.

Chem Cent J 2018 Oct 20;12(1):104. Epub 2018 Oct 20.

Shaanxi Key Laboratory of Petroleum for Fine Chemicals, Shaanxi Provincial Research and Design Institute of Petroleum and Chemical Industry, Xi'an, 710054, Shaanxi, China.

A series of TiO-VO-MCM-41 molecular sieve catalysts were prepared by the impregnation method. The prepared catalysts were characterized by different techniques including X-ray diffraction, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and N adsorption-desorption. These catalysts were applied in the catalytic synthesis of diphenyl carbonate (DPC) by the transesterification of dimethyl carbonate (DMC) with phenol. Read More

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http://dx.doi.org/10.1186/s13065-018-0474-6DOI Listing
October 2018
3 Reads

Correction to: Physicochemical properties of polysaccharides from Dendrobium officinale by fractional precipitation and their preliminary antioxidant and anti-HepG2 cells activities in vitro.

Chem Cent J 2018 Oct 11;12(1):103. Epub 2018 Oct 11.

School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.

The original version of the article [1] contained a mistake. The Figure legends are right, but the pictures in Figs. 3 and 4 are contrary. Read More

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http://dx.doi.org/10.1186/s13065-018-0471-9DOI Listing
October 2018
5 Reads

Comprehensive two-dimensional gas chromatography-mass spectrometry combined with multivariate data analysis for pattern recognition in Ecuadorian spirits.

Chem Cent J 2018 Oct 11;12(1):102. Epub 2018 Oct 11.

Institute of Chemistry, State University of Campinas, Cidade Universitária Zeferino Vaz, Campinas, SP, 13083-970, Brazil.

The current methodology used in quality control of Ecuadorian beverages such as Pájaro azúl, Puro and Pata de vaca is carried out by using conventional gas chromatography; however, it does not allow the fingerprinting of these Ecuadorian spirit beverages and their possible cases of adulteration. In order to overcome this drawback, comprehensive two-dimensional gas chromatography-mass spectrometry (GC × GC-MS) was combined with multivariate data analysis, revealing that compounds like citronellal, citronellol, geraniol, methyl anthranilate, (-)-trans-α-bergamotene, (-)-cis-α-bergamotene and D-limonene can be considered key elements for pattern recognition of these traditional beverages and product adulteration cases. Thus, the two-dimensional chromatographic fingerprints obtained by GC × GC-MS coupled with chemometric analysis, using Principal Component Analysis and Fisher-ratio can be considered as a potential strategy for adulteration recognition, and it may used as a quality assurance system for Ecuadorian traditional spirits. Read More

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https://ccj.springeropen.com/articles/10.1186/s13065-018-047
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http://dx.doi.org/10.1186/s13065-018-0470-xDOI Listing
October 2018
3 Reads

Pyridyl thiosemicarbazide: synthesis, crystal structure, DFT/B3LYP, molecular docking studies and its biological investigations.

Authors:
Sraa Abu-Melha

Chem Cent J 2018 Sep 29;12(1):101. Epub 2018 Sep 29.

Department of Chemistry, Faculty of Science of Girls, King Khaled University, Abha, Saudi Arabia.

N-(pyridin-2-yl)hydrazinecarbothioamide has been synthesized and characterized by single-crystal X-ray and spectroscopic techniques. Furthermore, its geometry optimization, calculated vibrational frequencies, non-linear optical properties, electrostatic potential and average local ionization energy properties of molecular surface were being evaluated using Jaguar program in the Schrödinger's set on the basis of the density functional concept to pretend the molecular geometry and predict properties of molecule performed by the hybrid density functional routine B3LYP. Furthermore, the docking study of N-(pyridin-2-yl)hydrazinecarbothioamide were applied against negative Escherichia coli bacterial and gram positive Staphylococcus aureus bacterial strains by Schrödinger suite program using XP glide protocol. Read More

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https://ccj.springeropen.com/articles/10.1186/s13065-018-046
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http://dx.doi.org/10.1186/s13065-018-0469-3DOI Listing
September 2018
3 Reads

Physicochemical properties of polysaccharides from Dendrobium officinale by fractional precipitation and their preliminary antioxidant and anti-HepG2 cells activities in vitro.

Chem Cent J 2018 Sep 25;12(1):100. Epub 2018 Sep 25.

School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.

Background: Dendrobium officinale as a precious traditional Chinese herb is widely used in medicines and health supplements. Thus the extraction, purification and biological activities of polysaccharides from the stem of Dendrobium officinale have significant meaning on theory and application value.

Methods: The crude Dendrobium officinale polysaccharide (DOP) was obtained by hot water extraction- ethanol precipitation method, and four new polysaccharide fractions (DOP-40, DOP-50, DOP-60, and DOP-70) were further obtained from the crude DOP by fractional precipitation with ethanol method, then four fractions were further purified by Toyopearl-H65F gel resin. Read More

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http://dx.doi.org/10.1186/s13065-018-0468-4DOI Listing
September 2018
3 Reads

Identification and characterization of in vivo, in vitro and reactive metabolites of vandetanib using LC-ESI-MS/MS.

Chem Cent J 2018 Sep 24;12(1):99. Epub 2018 Sep 24.

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Kingdom of Saudi Arabia.

Vandetanib (Caprelsa tablets, VNT) is an orally inhibitor of vascular endothelial growth factor receptor 2. The current research reports the characterization and identification of in vitro, in vivo and reactive intermediates of VNT. In vitro metabolites of VNT were performed by incubation with rat liver microsomes (RLMs). Read More

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http://dx.doi.org/10.1186/s13065-018-0467-5DOI Listing
September 2018
1 Read

Aesthetic compatibility assessment of consolidants for wall paintings by means of multivariate analysis of colorimetric data.

Chem Cent J 2018 Sep 21;12(1):98. Epub 2018 Sep 21.

Institute of Condensed Matter Chemistry and Technologies for Energy, National Research Council, Corso Stati Uniti 4, 35127, Padua, Italy.

Background And Methods: Wall paintings and architectural surfaces in outdoor environments are exposed to several physical, chemical and biological agents, hence they are often treated with different products to prevent or slow down their deterioration. Among the factors that have to be taken into account in the selection of the most suitable treatment for decorated surfaces, the aesthetic compatibility with the substrate is of great importance in the cultural heritage field; minimizing colour variation after treatment application is a crucial issue in particular for painted surfaces. In the framework of the European Project Nanomatch the color variation induced on wall painting mock-ups by the two innovative consolidants (calcium alkoxides) developed was evaluated using colorimetry in comparison with two traditional products. Read More

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http://dx.doi.org/10.1186/s13065-018-0465-7DOI Listing
September 2018
1 Read

Antimicrobial activities of saponins from Melanthera elliptica and their synergistic effects with antibiotics against pathogenic phenotypes.

Chem Cent J 2018 Sep 20;12(1):97. Epub 2018 Sep 20.

Groupe Isolement et Structure, Institut de Chimie Moléculaire de Reims (ICMR), CNRS, UMR 7312, Bat. 18, BP.1039, 51687, Reims cedex 2, France.

Background: Resistance of bacteria and fungi to antibiotics is one of the biggest problems that faces public health. The present work was designated to evaluate the antimicrobial activities of saponins from Melanthera elliptica and their synergistic effects with standard antibiotics against pathogenic phenotypes. The plant extract was prepared by maceration in methanol. Read More

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http://dx.doi.org/10.1186/s13065-018-0466-6DOI Listing
September 2018
4 Reads