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    Determination of antioxidant and antimicrobial activities of leaf extracts of Otostegia integrifolia.
    Chem Cent J 2018 May 18;12(1):63. Epub 2018 May 18.
    Department of Chemistry, College of Science, Bahir Dar University, P. O. Box 79, Bahir Dar, Ethiopia.
    Background: The extracts from the leaves of Otostegia integrifolia have been reported to show phytochemical analysis, total flavonoid content, antioxidant and antibacterial activities.

    Results: Our results revealed that the total flavonoid content of methanol and ethyl acetate extracts is 416.5 + 0. Read More

    Facile synthesis of α-alkoxymethyltriphenylphosphonium iodides: new application of PPh/I.
    Chem Cent J 2018 May 17;12(1):62. Epub 2018 May 17.
    H.E.J Research Institute of Chemistry, ICCBS, University of Karachi, Karachi, 75270, Pakistan.
    An efficient one pot method for the synthesis of α-alkoxymethylphosphonium iodides is developed by using PPh/I combination at room temperature. Reaction conditions are found general to synthesize wide range of structurally variant alkoxymethylphosphonium iodides in high yield (70-91%). These new functionalized phosphonium salts are further used in stereoselective synthesis of vinyl ethers as well as in carbon homologation of aldehydes. Read More

    Characterization of in vivo metabolites in rat urine following an oral dose of masitinib by liquid chromatography tandem mass spectrometry.
    Chem Cent J 2018 May 15;12(1):61. Epub 2018 May 15.
    Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.
    Masitinib (MST) is an orally administered drug that targets mast cells and macrophages, important cells for immunity, by inhibiting a limited number of tyrosine kinases. It is currently registered in Europe and USA for the treatment of mast cell tumors in dogs. AB Science announced that the European Medicines Agency has accepted a conditional marketing authorization application for MST to treat amyotrophic lateral sclerosis. Read More

    New fluorescence spectroscopic method for the simultaneous determination of alkaloids in aqueous extract of green coffee beans.
    Chem Cent J 2018 May 11;12(1):59. Epub 2018 May 11.
    Department of Chemistry, College of Natural Sciences, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia.
    Background: There is no fluorescence spectroscopic method for the determination of trigonelline and theobromine in green coffee beans. Therefore, the objective of this study was to develop a new fluorescence spectroscopic method to determine the alkaloids simultaneously in the aqueous extract of green coffee beans.

    Results: The calibration curves were linear in the range 2-6, 1-6, 1-5 mg/L for caffeine, theobromine and trigonelline, respectively, with R ≥ 0. Read More

    Chemical variability in the essential oil of leaves of Araçá (Psidium guineense Sw.), with occurrence in the Amazon.
    Chem Cent J 2018 May 10;12(1):52. Epub 2018 May 10.
    Programa de pós-graduação em Química, Universidade Federal do Pará, 66075-900, Belém, PA, Brazil.
    Background: Psidium guineense, known as Araçá, is a Brazilian botanical resource with commercial application perspectives, based on the functional elements of its fruits and due to the use of its leaves as an anti-inflammatory and antibacterial agent. The essential oils of leaves of twelve specimens of Araçá were analyzed by GC and GC-MS to identify their volatile constituents and associate them with the biological activities reputed to the plant.

    Results: In a total of 157 identified compounds, limonene, α-pinene, β-caryophyllene, epi-β-bisabolol, caryophyllene oxide, β-bisabolene, α-copaene, myrcene, muurola-4,10(14)-dien-1-β-ol, β-bisabolol, and ar-curcumene were the primary components in descending order up to 5%. Read More

    Stereoselective synthesis, X-ray analysis, computational studies and biological evaluation of new thiazole derivatives as potential anticancer agents.
    Chem Cent J 2018 May 11;12(1):56. Epub 2018 May 11.
    Institut für Organische Chemie, Universitӓt Stuttgart, Pfaffenwaldring 55, 70569, Stuttgart, Germany.
    Background: The synthesis of new thiazole derivatives is very important because of their diverse biological activities. Also , many drugs containing thiazole ring in their skeletons are available in the market such as Abafungin, Acotiamide, Alagebrium, Amiphenazole, Brecanavir, Carumonam, Cefepime, and Cefmatilen.

    Results: Ethyl cyanoacetate reacted with phenylisothiocyanate, chloroacetone, in two different basic mediums to afford the thiazole derivative 6, which reacted with dimethylformamide- dimethyl acetal in the presence of DMF to afford the unexpected thiazole derivative 11. Read More

    Structural determinants influencing halogen bonding: a case study on azinesulfonamide analogs of aripiprazole as 5-HT, 5-HT, and D receptor ligands.
    Chem Cent J 2018 May 11;12(1):55. Epub 2018 May 11.
    Department of Medicinal Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Krakow, Poland.
    A series of azinesulfonamide derivatives of long-chain arylpiperazines with variable-length alkylene spacers between sulfonamide and 4-arylpiperazine moiety is designed, synthesized, and biologically evaluated. In vitro methods are used to determine their affinity for serotonin 5-HT, 5-HT, 5-HT, and dopamine D receptors. X-ray analysis, two-dimensional NMR conformational studies, and docking into the 5-HT and 5-HT receptor models are then conducted to investigate the conformational preferences of selected serotonin receptor ligands in different environments. Read More

    Validation of analytical method for rhynchophorol quantification and stability in inorganic matrix for the controlled release of this pheromone.
    Chem Cent J 2018 May 10;12(1):54. Epub 2018 May 10.
    Faculty of Pharmacy/RENORBIO, Federal University of Bahia, Rua Barão de Jeremoabo, 147, Campus Universitário de Ondina, Salvador, BA, 40170-115, Brazil.
    A fast method for the identification and stability evaluation of the aggregation pheromone rhynchophorol, which is the main substance used for chemical communication by the beetle Rhynchophorus palmarum L., was validated. In addition, the technique was applied to the evaluation of two inorganic matrices, with the objective of using them as controlled-release devices. Read More

    Dioscorea nipponica Makino: a systematic review on its ethnobotany, phytochemical and pharmacological profiles.
    Chem Cent J 2018 May 11;12(1):57. Epub 2018 May 11.
    School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong Special Administrative Region, China.
    Dioscorea nipponica Makino is a perennial twining herbs belonging to the family Dioscoreaceae, which is mainly distributed in the northeastern, northern, eastern and central regions of China. Traditionally, the rhizome of this herb has been commonly used by Miao and Meng ethnic groups of China to treat rheumatoid arthritis, pain in the legs and lumbar area, Kashin Beck disease, bruises, sprains, chronic bronchitis, cough and asthma. Modern pharmacological studies have discovered that this herb possesses anti-tumor, anti-inflammatory, anti-diuretic, analgesic, anti-tussive, panting-calming and phlegm-dispelling activities, along with enhancing immune function and improving cardiovascular health. Read More

    BODIPY dyads and triads: synthesis, optical, electrochemical and transistor properties.
    Chem Cent J 2018 May 11;12(1):60. Epub 2018 May 11.
    Department of Chemistry, University of Massachusetts Amherst, Amherst, 10300, USA.
    A series of D-A dyads and D-A-D triads molecular systems based on triphenylamine and 9-ethyl-carbarzole as donor (D) and BODIPY as acceptor (A) has been designed and synthesized. The optoelectronic properties including optical, electrochemical, and charge carrier mobility of these molecules have been investigated. We found that the D-A-D triads exhibited broader absorption, raising the HOMO energy levels and increase hole carrier mobilities. Read More

    In vitro and in silico studies of terpenes, terpenoids and related compounds with larvicidal and pupaecidal activity against Culex quinquefasciatus Say (Diptera: Culicidae).
    Chem Cent J 2018 May 10;12(1):53. Epub 2018 May 10.
    Facultad de Ciencias Químicas, Universidad Autónoma de Chihuahua, Circuito Universitario S/N, Campus Universitario II., Chihuahua, Chihuahua, Mexico.
    Background: In order to develop new larvicidal agents derived from phytochemicals, the larvicidal activity of fifty molecules that are constituent of essential oils was evaluated against Culex quinquefasciatus Say. Terpenes, terpenoids and phenylpropanoids molecules were included in the in vitro evaluation, and QSAR models using genetic algorithms were built to identify molecular and structural properties of biological interest. Further, to obtain structural details on the possible mechanism of action, selected compounds were submitted to docking studies on sterol carrier protein-2 (SCP-2) as possible target. Read More

    Design, synthesis and evaluation of anticancer activity of novel 2-thioxoimidazolidin-4-one derivatives bearing pyrazole, triazole and benzoxazole moieties.
    Chem Cent J 2018 May 9;12(1):51. Epub 2018 May 9.
    Department of Chemistry, Faculty of Applied Sciences, Umm Al-Qura University, P. O. Box 13401, Makkah, 21955, Saudi Arabia.
    A novel series of substituted 2-thiohydantoin incorporated with benzoimidazole, pyrazole, triazole and/or benzoxazole moieties has been synthesized using (E)-3-[1-(4-bromophenyl)ethylideneamino]-2-thioxoimidazolidin-4-one 1 as the key starting material. The key material 1 also, reacted with an acetic anhydride, aromatic aldehydes, secondary amines, formaldehyde and triethyl orthoformate to give the corresponding acetyl, chalcone, Mannich bases and ethoxymethylene derivatives, respectively. The structures of the novel compounds were confirmed by spectral data and elemental analysis. Read More

    Microwave assisted synthesis of some new thiazolopyrimidine and pyrimidothiazolopyrimidopyrimidine derivatives with potential antimicrobial activity.
    Chem Cent J 2018 May 5;12(1):50. Epub 2018 May 5.
    Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt.
    Background And Objective: A series of thiazolopyrimidine derivatives have been synthesized via multicomponent reaction and tested for biological activities. This research aims to develop a new synthetic method of poly fused pyrimidines under microwave irradiation. 6-Amino-4-aryl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitriles reacted with bromomalono-nitrile to give 3,7-diamino-5-aryl-5H-thiazolo[3,2-a]pyrimidine-2,6-dicarbonitrile more willingly than the isomeric 7H-thiazolo[3,2-a]pyrimidines. Read More

    Palladium(0) catalyzed Suzuki cross-coupling reaction of 2,5-dibromo-3-methylthiophene: selectivity, characterization, DFT studies and their biological evaluations.
    Chem Cent J 2018 May 4;12(1):49. Epub 2018 May 4.
    HEJ Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
    Thiophene derivatives have shown versatile pharmacological activities. The Suzuki reaction proved a convenient method for C-C bond formations in organic molecules. In the present research work novel derivatives of 2,5-dibromo-3-methylthiophene (3a-k and 3l-p) has been synthesized, via Suzuki coupling reaction in low to moderate yields. Read More

    Study on the interaction between active components from traditional Chinese medicine and plasma proteins.
    Chem Cent J 2018 May 4;12(1):48. Epub 2018 May 4.
    School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, China.
    Traditional Chinese medicine (TCM), as a unique form of natural medicine, has been used in Chinese traditional therapeutic systems over two thousand years. Active components in Chinese herbal medicine are the material basis for the prevention and treatment of diseases. Research on drug-protein binding is one of the important contents in the study of early stage clinical pharmacokinetics of drugs. Read More

    Development and validation of an HPLC-MS/MS method for the determination of arginine-vasopressin receptor blocker conivaptan in human plasma and rat liver microsomes: application to a metabolic stability study.
    Chem Cent J 2018 May 2;12(1):47. Epub 2018 May 2.
    Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.
    Purpose: To develop and validate a bio-analytical HPLC-MS/MS method for the determination of conivaptan (CVA) an arginine-vasopressin receptor blocker in human plasma and in rat liver microsomes (RLMs).

    Methods: Analytes were separated on a reversed phase C18 column (50 mm × 2.1 mm, 1. Read More

    Synthesis of antibacterial poly(o-chloroaniline)/chromium hybrid composites with enhanced electrical conductivity.
    Chem Cent J 2018 Apr 26;12(1):46. Epub 2018 Apr 26.
    Department of Information Technology and Electronics, Zhejiang University, Hangzhou, 310027, China.
    Electrically conductive polyorthochloroaniline/chromium nanocomposites (POC/Cr NCs) were prepared by in situ chemical oxidative polymerization of orthochloroaniline in the presence of Cr nanoparticles (Cr NPs). The load percentage of Cr nanofiller was varied in POC matrix to investigate the effect of Cr nanoparticles on the properties of the nanocomposites. The composition, structure, and morphology of POC and its composites were examined by Scanning electron microscopy, Fourier transform infrared spectroscopy, and UV-visible spectroscopic analysis. Read More

    Preparation and application of melamine cross-linked poly ammonium as shale inhibitor.
    Chem Cent J 2018 Apr 25;12(1):44. Epub 2018 Apr 25.
    Shaanxi Province Key Laboratory of Environmental Pollution Control and Reservoir Protection Technology of Oilfields, Xi'an, 710065, China.
    In this paper, a series of poly ammonium shale inhibitors were prepared from diethylamine, epichlorohydrin, and melamine (DEM) and their inhibition to shale were evaluated by bentonite linear expansion test, anti-swelling experiments, and mud ball experiments. Additionally, other properties of drilling fluid treated by poly ammonium were evaluated. Anti-swelling results showed that anti-swelling rate of DEM-8 reaches up to 97. Read More

    Identification of characteristic aroma compounds in raw and thermally processed African giant snail (Achatina fulica).
    Chem Cent J 2018 Apr 24;12(1):43. Epub 2018 Apr 24.
    Department of Food Technology, University Putra Malaysia, UPM, 43400, Serdang, Malaysia.
    Background: Food flavor appreciation is one of the first signals along with food appearance and texture encountered by consumers during eating of food. Also, it is well known that flavor can strongly influence consumer's acceptability judgment. The increase in the consumption of snail meat across the world calls for the need to research into the aroma compounds responsible for the distinctive aroma notes of processed snail meat. Read More

    The determination of Ochratoxin A based on the electrochemical aptasensor by carbon aerogels and methylene blue assisted signal amplification.
    Chem Cent J 2018 Apr 25;12(1):45. Epub 2018 Apr 25.
    College of Food Science and Technology, Henan University of Technology, Zhengzhou, 450001, People's Republic of China.
    In this work, a novel aptamer-based electrochemical biosensor was developed for the determination of Ochratoxin A (OTA) by using carbon aerogels (CAs) and methylene blue (MB) as signal amplification strategy. CAs was used as carrier to load the abundant of complementary DNA (cDNA), which could enhance the hybridization between CAs-cDNA and aptamer immobilized on the electrode surface, thus provide more double-stranded DNA for MB intercalation. The current of MB on the CAs-cDNA/apt/AuE sensor was twice that on the cDNA/apt/AuE sensor, which indicated that the CAs with high surface area enabled a higher loading of the cDNA and absorbed more MB, thus realized the signal amplification strategy. Read More

    Exploration of Phyllanthus acidus mediated silver nanoparticles and its activity against infectious bacterial pathogen.
    Chem Cent J 2018 Apr 20;12(1):42. Epub 2018 Apr 20.
    Department of Virology, Sri Venkateswara University, Tirupati, 517570, Andhra Pradesh, India.
    In our present investigation, synthesis of nontoxic, eco friendly and cost effective silver nanoparticles, Phyllanthus acidus (P. acidus) was used as starting material. The influence of phyto-constituents present in aqueous extracts of Phyllanthus acidus was found to be effective in reduction of silver nitrate to free silver nanoparticles (PA-AgNPs). Read More

    Targeting matrix metalloproteinases with novel diazepine substituted cinnamic acid derivatives: design, synthesis, in vitro and in silico studies.
    Chem Cent J 2018 Apr 20;12(1):41. Epub 2018 Apr 20.
    Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, 124001, India.
    Lung cancer is the notable cause of cancer associated deaths worldwide. Recent studies revealed that the expression of matrix metalloproteinases (MMPs) is extremely high in lung tumors compared with non-malignant lung tissue. MMPs (-2 and -9) play an important part in tumor development and angiogenesis, which suggests that creating potent MMP-2 and -9 inhibitors, should be an important goal in lung cancer therapy. Read More

    Simultaneous identification and determination of flavonoids in Dendrobium officinale.
    Chem Cent J 2018 Apr 12;12(1):40. Epub 2018 Apr 12.
    School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, 232 Outer Circle Road East, Guangzhou Higher Education Mega Center, Guangzhou, 510006, China.
    Background: The quality of material medicine resources has had a considerable impact on the development of the health industry, which has created a bottleneck for traditional Chinese medicine (TCM). Dendrobium officinale, which has been widely used for health prevention in TCM, has become a high-nutritive health food that is strongly recommended by many white-collar workers and people who pay more attention to their health. The aim of this study was to develop a method to authenticate and evaluate D. Read More

    Lipase catalyzed epoxidation of fatty acid methyl esters derived from unsaturated vegetable oils in absence of carboxylic acid.
    Chem Cent J 2018 Apr 11;12(1):39. Epub 2018 Apr 11.
    Facultad de Ciencias Químicas, Universidad Autónoma de Chihuahua, Nuevo Circuito Universitario, 31125, Chihuahua, Mexico.
    Nowadays the industrial chemistry reactions rely on green technologies. Enzymes as lipases are increasing its use in diverse chemical processes. Epoxidized fatty acid methyl esters obtained from transesterification of vegetable oils have recently found applications as polymer plasticizer, agrochemical, cosmetics, pharmaceuticals and food additives. Read More

    5-Hydroxymethylfurfural (HMF) levels in honey and other food products: effects on bees and human health.
    Chem Cent J 2018 Apr 4;12(1):35. Epub 2018 Apr 4.
    School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor, Malaysia.
    An organic compound known as 5-hydroxymethylfurfural (HMF) is formed from reducing sugars in honey and various processed foods in acidic environments when they are heated through the Maillard reaction. In addition to processing, storage conditions affect the formation HMF, and HMF has become a suitable indicator of honey quality. HMF is easily absorbed from food through the gastrointestinal tract and, upon being metabolized into different derivatives, is excreted via urine. Read More

    Comparison of the antioxidant effects of carnosic acid and synthetic antioxidants on tara seed oil.
    Chem Cent J 2018 Apr 4;12(1):37. Epub 2018 Apr 4.
    Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin, 150040, China.
    Background: In the present study, tara seed oil was obtained by supercritical fluid extraction and used to investigate the antioxidant strength of carnosic acid (CA) compared with conventional synthetic antioxidants.

    Methods: The antioxidants were added to the tara seed oil at 0.2 mg of antioxidant per gram of oil. Read More

    The highly selective oxidation of cyclohexane to cyclohexanone and cyclohexanol over VAlPO berlinite by oxygen under atmospheric pressure.
    Chem Cent J 2018 Apr 4;12(1):36. Epub 2018 Apr 4.
    Department of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, 510006, China.
    Background: The oxidation of cyclohexane under mild conditions occupies an important position in the chemical industry. A few soluble transition metals were widely used as homogeneous catalysts in the industrial oxidation of cyclohexane. Because heterogeneous catalysts are more manageable than homogeneous catalysts as regards separation and recycling, in our study, we hydrothermally synthesized and used pure berlinite (AlPO) and vanadium-incorporated berlinite (VAlPO) as heterogeneous catalysts in the selective oxidation of cyclohexane with molecular oxygen under atmospheric pressure. Read More

    Therapeutic potential of heterocyclic pyrimidine scaffolds.
    Chem Cent J 2018 Apr 4;12(1):38. Epub 2018 Apr 4.
    Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India.
    Heterocyclic compounds offer a high degree of structural diversity and have proven to be broadly and economically useful as therapeutic agents. Comprehensive research on diverse therapeutic potentials of heterocycles compounds has confirmed their immense significance in the pathophysiology of diseases. Heterocyclic pyrimidine nucleus, which is an essential base component of the genetic material of deoxyribonucleic acid, demonstrated various biological activities. Read More

    Eugenol derivatives: synthesis, characterization, and evaluation of antibacterial and antioxidant activities.
    Chem Cent J 2018 Apr 3;12(1):34. Epub 2018 Apr 3.
    Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Norte (IFRN), RN 233, Km 02 N°999, Chapada do Apodi, Apodi, RN, 59700-000, Brazil.
    Eugenol is the major component of clove essential oil and has demonstrated relevant biological potential with well-known antimicrobial and antioxidant action. Therefore, this work carried out the synthesis, purification, characterization, and evaluation of the antioxidant and antibacterial potential of 19 eugenol derivatives. The derivatives were produced by esterification reactions in the hydroxyl group (-OH) of eugenol with different carboxylic acids and also by addition reactions in the double bond of the allyl group. Read More

    Molecular recognition of flunarizine dihydrochloride and β-cyclodextrin inclusion complex by NMR and computational approaches.
    Chem Cent J 2018 Mar 28;12(1):33. Epub 2018 Mar 28.
    Department of Chemistry, Aligarh Muslim University, Aligarh, 202002, UP, India.
    Background: Flunarizine dihydrochloride (FLN) is used in the prophylactic treatment of migraine, vertigo, occlusive peripheral vascular disease and epilepsy. Cyclodextrins (CDs) are chiral, truncated cone shaped macrocycles known for their inner hydrophobic and outer hydrophilic site. They form complexes with hydrophobic drug molecules and enhance the solubility and bioavailability of such compounds by enhancing drug permeability through mucosal tissues. Read More

    QSAR study and rustic ligand-based virtual screening in a search for aminooxadiazole derivatives as PIM1 inhibitors.
    Chem Cent J 2018 Mar 22;12(1):32. Epub 2018 Mar 22.
    MCNSL, School of Sciences, Moulay Ismail University, Meknes, Morocco.
    Background: Quantitative structure-activity relationship (QSAR) was carried out to study a series of aminooxadiazoles as PIM1 inhibitors having pk ranging from 5.59 to 9.62 (k in nM). Read More

    Design, synthesis and cytotoxic effects of curcuminoids on HeLa, K562, MCF-7 and MDA-MB-231 cancer cell lines.
    Chem Cent J 2018 Mar 19;12(1):31. Epub 2018 Mar 19.
    Research Institute of Natural Products for Drug Discovery (RiND), NMR Facility Division, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300, Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia.
    Background: Curcumin is one of the leading compound extracted from the dry powder of Curcuma longa (Zingiberaceae family), which possess several pharmacological properties. However, in vivo administration exhibited limited applications in cancer therapies.

    Results: Twenty-four curcumin derivatives have synthesized, which comprises cyclohexanone 1-10, acetone 11-17 and cyclopentanone 18-24 series. Read More

    Synthesis, antimicrobial activity, pharmacophore modeling and molecular docking studies of new pyrazole-dimedone hybrid architectures.
    Chem Cent J 2018 Mar 14;12(1):29. Epub 2018 Mar 14.
    Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75210, Pakistan.
    Background: Design and synthesis of pyrazole-dimedone derivatives were described by one-pot multicomponent reaction as new antimicrobial agents. These new molecular framework were synthesized in high yields with a broad substrate scope under benign conditions mediated by diethylamine (NHEt). The molecular structures of the synthesized compounds were assigned based on different spectroscopic techniques (H-NMR, C-NMR, IR, MS, and CHN). Read More

    Rice bran nanofiber composites for stabilization of phytase.
    Chem Cent J 2018 Mar 14;12(1):28. Epub 2018 Mar 14.
    Sri Lanka Institute of Nanotechnology, Centre for Excellence, Nanoscience and Technology Park, Pitipana, Homagama, Sri Lanka.
    This study explores the potential application of rice bran (agro waste) to nano-encapsulate phytase, which is a thermally unstable biologically active enzyme. Rice bran was converted to nanofibers (20-50 nm in diameter) using electrospinning. After optimizing the pH, viscosity, voltage and the distance between electrodes for electrospinning, phytase enzyme was encapsulated and the fibers were cross-linked using sodium tripolyphosphate. Read More

    The effect of melanin-free extract from Sepia esculenta ink on lipid peroxidation, protein oxidation and water-holding capacity of tilapia fillet during cold storage.
    Chem Cent J 2018 Mar 14;12(1):30. Epub 2018 Mar 14.
    College of Food Science & Technology, Guangdong Ocean University, Zhanjiang, 524088, China.
    Background: Preservative effect of melanin-free extract of Sepia esculenta ink (MFESI) on Sparus latus fillet has been verified in our previous work. This study aims to further approach the mechanism of MFESI for extending the shelf-life of fish fillet during cold storage. Tilapia fillets were treated with different dosage of MFESI (0, 15, 25 and 35 mg/ml) and packed with preservative film for succedent cold-storage at 4 °C for scheduled time. Read More

    Optimized method for determination of 16 FDA polycyclic aromatic hydrocarbons (PAHs) in mainstream cigarette smoke by gas chromatography-mass spectrometry.
    Chem Cent J 2018 Mar 13;12(1):27. Epub 2018 Mar 13.
    British American Tobacco, Research and Development, Southampton, UK.
    A gas chromatography-mass spectrometry (GC-MS) method was validated for the determination of 16 polycyclic aromatic hydrocarbons (PAHs) from the FDA list of 93 harmful or potentially harmful constituents of mainstream cigarette smoke (MCS). Target analytes were extracted from total particulate matter using accelerated solvent extraction with a toluene/ethanol solvent mixture. Matrix artefacts were removed by two-step solid-phase extraction process. Read More

    Experimental and theoretical study of donor-π-acceptor compounds based on malononitrile.
    Chem Cent J 2018 Mar 9;12(1):26. Epub 2018 Mar 9.
    Chemistry Department, Faculty of Science, King Abdulaziz University, P. O. Box 80203, Jeddah, Saudi Arabia.
    A set of different donor-π-acceptor compounds having dicyanovinyl as the acceptor and aryl moieties as donors were synthesized by Knoevenagel condensation. The UV-visible absorption and fluorescence spectra were investigated in different solvents. The optical band gab energy (Eg) was linearly correlated with the Hammett resonance effect of the donor to reveal that the higher the value of Hammett resonance effect of a donor, the lower the Eg of the molecule. Read More

    Synthesis and characterization of novel iminobenzoates with terminal pyrazine moieties.
    Chem Cent J 2018 Mar 8;12(1):25. Epub 2018 Mar 8.
    Medicinal Botanic Centre PCSIR Labs Complex, University Road, Peshawar, 25120, Pakistan.
    Apart from its numerous biological activities like antidiabetic, anti-inflammatory, antimicrobial, pyrazine moiety plays an important role in luminescent materials. Its role in luminescent materials is due to its highly electron deficient nature specially when it is in the centre along the mainstay of extended π-conjugated systems. Similarly, new liquid crystalline compounds are being made constantly where the central benzoaromatic moiety is being replaced with the heterocycles including pyrazine due to their more variable nature. Read More

    Synthesis, structural determination and antimicrobial evaluation of two novel Co and Zn halogenometallates as efficient catalysts for the acetalization reaction of aldehydes.
    Chem Cent J 2018 Mar 1;12(1):24. Epub 2018 Mar 1.
    Laboratoire Physicochimie de l'Etat Solide, Département de Chimie, Faculté des Sciences de Sfax, Université de Sfax, BP 1171, 3000, Sfax, Tunisia.
    Background: Complexes of imidazole derivatives with transition metal ions have attracted much attention because of their biological and pharmacological activities, such as antimicrobial, antifungal, antiallergic, antitumoural and antimetastatic properties. In addition, imidazoles occupy an important place owing to their meaningful catalytic activity in several processes, such as in hydroamination, hydrosilylation, Heck reaction and Henry reaction. In this work, we describe the crystallization of two halogenometallate based on 2-methylimidazole. Read More

    Simultaneous determination of myricetrin, quercitrin and afzelin in leaves of Cercis chinensis by a fast and effective method of ionic liquid microextraction coupled with HPLC.
    Chem Cent J 2018 Mar 1;12(1):23. Epub 2018 Mar 1.
    Institute of Chinese Materia Medica, Henan University, Kaifeng, 475004, Henan, China.
    In this study, the contents of myricetrin, quercitrin and afzelin in Cercis chinensis leaves were determined simultaneously by 1-butyl-3-methylimidazolium tetrafluoroborate [BMIM] BF/70% ethanol microextraction combined with High Performance Liquid Chromatograph (HPLC) analysis. The mobile phase was eluted with an Agilent ZORBAX SB-C18 column (4.6 mm×5 mm, 5 μm), B was methanol and C was 0. Read More

    Thermogravimetric analysis, kinetic study, and pyrolysis-GC/MS analysis of 1,1'-azobis-1,2,3-triazole and 4,4'-azobis-1,2,4-triazole.
    Chem Cent J 2018 Mar 1;12(1):22. Epub 2018 Mar 1.
    School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China.
    Background: In general, the greater the number of directly linked nitrogen atoms in a molecule, the better its energetic performance, while the stability will be accordingly lower. But 1,1'-azobis-1,2,3-triazole (1) and 4,4'-azobis-1,2,4-triazole (2) show remarkable properties, such as high enthalpies of formation, high melting points, and relatively high stabilities. In order to rationalize this unexpected behavior of the two compounds, it is necessary to study their thermal decompositions and pyrolyses. Read More

    Relationship between the binding free energy and PCBs' migration, persistence, toxicity and bioaccumulation using a combination of the molecular docking method and 3D-QSAR.
    Chem Cent J 2018 Feb 23;12(1):20. Epub 2018 Feb 23.
    College of Environmental Science and Engineering, North China Electric Power University, No. 2, Beinong Road, Beijing, 102206, China.
    The molecular docking method was used to calculate the binding free energies between biphenyl dioxygenase and 209 polychlorinated biphenyl (PCB) congeners. The relationships between the calculated binding free energies and migration (octanol-air partition coefficients, K), persistence (half-life, t), toxicity (half maximal inhibitory concentration, IC), and bioaccumulation (bioconcentration factor, BCF) values for the PCBs were used to gain insight into the degradation of PCBs in the presence of biphenyl dioxygenase. The relationships between the calculated binding free energies and the molecular weights, K, BCF, and t values for the PCBs were statistically significant (P < 0. Read More

    A new family of azanaphthoquinones for antimicrobial evaluation.
    Chem Cent J 2018 Feb 23;12(1):21. Epub 2018 Feb 23.
    Chemistry Department, Engineering Faculty, Istanbul University, 34320, Avcilar, Istanbul, Turkey.
    This article presents a complete and detailed study of synthesis, structural characterization, and possible applications of a new family of azanaphthoquinones as antimicrobial agents. A series of (alkoxy)phenylamino-chloro-2-methylquinoline-5,8-dione derivatives (3a-j, 3a', 3e') was prepared by regioselective nucleophilic substitution of 6,7-dichloro-2-methylquinoline-5,8-dione (1) with (alkoxy)arylamines (2) in the presence of CeCl·7HO. In vitro antimicrobial study of the newly synthesized compounds was evaluated in a panel of three fungi and seven bacterial strains (three Gram-positive and four Gram-negative bacteria). Read More

    Synthesis of molecular imprinting polymers for extraction of gallic acid from urine.
    Chem Cent J 2018 Feb 21;12(1):19. Epub 2018 Feb 21.
    School of Chemical Sciences, Universiti Sains Malaysia, 11800, Gelugor, Penang, Malaysia.
    The molecularly imprinted polymers for gallic acid were synthesized by precipitation polymerization. During the process of synthesis a non-covalent approach was used for the interaction of template and monomer. In the polymerization process, gallic acid was used as a template, acrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker and 2,2'-azobisisobutyronitrile as an initiator and acetonitrile as a solvent. Read More

    Synthesis of multifunctional activated carbon nanocomposite comprising biocompatible flake nano hydroxyapatite and natural turmeric extract for the removal of bacteria and lead ions from aqueous solution.
    Chem Cent J 2018 Feb 21;12(1):18. Epub 2018 Feb 21.
    Department of Chemistry, University of Colombo, Colombo, 00300, Sri Lanka.
    Clean water, which is free from pathogens and toxic chemicals, is vital to human health. The blue planet is encountering remarkable challenges in meeting the ever-increasing demands of clean water. The intention of this research study was to develop a water filter material that is capable of removing bacterial contaminants and heavy metals from fresh water using cost effective and easily fabricated biocompatible filter material. Read More

    Phytochemical constituents, antioxidant activity, and antiproliferative properties of black, red, and brown rice bran.
    Chem Cent J 2018 Feb 17;12(1):17. Epub 2018 Feb 17.
    Department of Nutrition & Dietetics, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
    Background: In the recent years, the health benefits of the pigmented rice varieties have reported due to the presence of bioactive compounds. In this study, the phytochemical constituents (total phenolic, flavonoid and anthocyanin content) and individual phenolics and flavonoids of the extracts of sixteen genotypes of pigmented rice bran were evaluated using spectrophotometric and ultra-high performance liquid chromatography method. Antioxidative properties of the free and bound fractions were evaluated using nitric oxide and 1,1-diphenyl-2-picrylhydrazyl scavenging assays. Read More

    Anti-inflammatory effect of oligostilbenoids from Vitis heyneana in LPS-stimulated RAW 264.7 macrophages via suppressing the NF-κB activation.
    Chem Cent J 2018 Feb 13;12(1):14. Epub 2018 Feb 13.
    Department of Biomedical Sciences, Institute for Research and Executive Education (VNUK), The University of Danang, 41 Le Duan, Haichau district, Danang, 551000, Vietnam.
    Background: Vitis heyneana is widely distributed in the north of Vietnam, it has been used in Vietnamese traditional medicine as an agent for treatment of arthritis, bronchitis, carbuncles and inflammatory conditions, and menstrual irregularities. However, this plant has not been investigated in phytochemical constituents and biological effects, especially in the anti-inflammatory property.

    Results: Bioassay-guided fractionation of the EtOAc soluble fraction from the aerial part of Vitis heyneana resulted in the isolation of a series of oligostilbenoids as piceid (1), 2-r-viniferin (2), betulifol A (3), vitisinol C (4), (-)-trans-ε-viniferin (5), α-viniferin (6), shoreaketon (7), amurensin B (8), vitisinol B (9), and cis-vitisin B (10). Read More

    QSAR study on the removal efficiency of organic pollutants in supercritical water based on degradation temperature.
    Chem Cent J 2018 Feb 13;12(1):16. Epub 2018 Feb 13.
    School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
    This paper aims to study temperature-dependent quantitative structure activity relationship (QSAR) models of supercritical water oxidation (SCWO) process which were developed based on Arrhenius equation between oxidation reaction rate and temperature. Through exploring SCWO process, each kinetic rate constant was studied for 21 organic substances, including azo dyes, heterocyclic compounds and ionic compounds. We propose the concept of T, which is defined as the temperature at removal ratio of 95%, it is a key indicator to evaluate compounds' complete oxidation. Read More

    Effect of crosslinking concentration on properties of 3-(trimethoxysilyl) propyl methacrylate/N-vinyl pyrrolidone gels.
    Chem Cent J 2018 Feb 13;12(1):15. Epub 2018 Feb 13.
    Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
    Background: The incorporation of two different monomers, having different properties, in the same polymer molecule leads to the formation of new materials with great scientific and commercial importance. The basic requirements for polymeric materials in some areas of biomedical applications are that they are hydrophilic, having good mechanical and thermal properties, soft, and oxygen-permeable.

    Results: A series of 3-(trimethoxysilyl) propyl methacrylate/N-vinyl pyrrolidone (TMSPM/NVP) xerogels containing different concentration of ethylene glycol dimethacrylate (EGDMA) as crosslinking agent were prepared by bulk polymerization to high conversion using BPO as initiator. Read More

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