4,290,426 results match your criteria Chemistry Central Journal [Journal]
Nanotechnology 2018 Dec 17. Epub 2018 Dec 17.
Materials Science&Engineering, East China University of Science and Technology, No.130, Meilong Rd, Xuhui District, Shanghai, Shanghai, 200237, CHINA.
Although the special architecture of two-dimensional (2D) nanomaterials endows them with unique properties, their poor colloidal stability remains a main bottleneck to fully exploit their applications in the biomedical field. Herein, this study aims to develop a simple and effective approach to in situ incorporate 2D graphene oxide (GO) nanopletlets into thermosensitive matrix to acquire hybrid nanogels with good stability and photothermal effect. In order to improve its stability, GO firstly underwent silanization to its surface with double bonds, followed by intercalation with N-isopropylacrylamide (NIPAM) in the presence of disulfide-containing crosslinker via an emulsion method. Read More
Biomed Mater 2018 Dec 17. Epub 2018 Dec 17.
Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai, CHINA.
Biological regeneration of articular cartilage continues to be a challenge at present. Functional engineered implants with patient-specific sizes are difficult to achieve. The aim of this study is to fabricate a biocompatible cell-laden hydrogel with a designable structure. Read More
J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.
J Xiao, The College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China.
Puberty onset is a complex trait regulated by multiple genetic and environmental factors. In this study, we narrowed a puberty related QTL region down to a 1.7 Mb region on chromosome X in female mice and inferred miR-505-3p as the functional gene. Read More
Biosens Bioelectron 2018 Dec 7;126:800-805. Epub 2018 Dec 7.
Department of Chemistry, Capital Normal University, Beijing 100048, China. Electronic address:
Enzyme-linked immunosorbent assay (ELISA), a gold-standard method for protein detection, has been widely utilized in disease diagnosis. Nevertheless, the method is constrained by its dependence on a colorimetric readout that, due to its relatively low sensitivity, prevents its use in tumor marker detection. Here we demonstrate an ELISA that incorporates an electro-readout mode in place of a colorimetric readout to achieve ultrasensitive and convenient tumor marker detection. Read More
Eur J Med Chem 2018 Dec 4;163:583-596. Epub 2018 Dec 4.
State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, No. 38 Xueyuan Road, 100191, Haidian District, Beijing, China. Electronic address:
Sulfated hyaluronic acid (sHA) is chemically synthetic mimetic of glycosaminoglycan (GAG) presenting promising biological functions. Specific sulfation pattern, termed as sulfation code plays critical roles in regulating the binding mode between GAG and proteins. As a structural analogue of chondroitin sulfate (CS), sHA bears much higher molecular weight and is nearly free of other proteoglycan contaminants. Read More
Water Res 2018 Nov 28;150:442-451. Epub 2018 Nov 28.
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, China.
The competitive removal of Pb and malachite green (MG) from water by three magnetic phosphate nanocomposites (FeO/Ba(PO), FeO/Sr(PO)(OH), and FeO/SrBa(PO)(OH), namely "FBP", "FSP", and "FSBP", respectively) was systematically investigated compared with FeO ("F") nanoparticle. Temperature and adsorbent dosage for competitive removal were optimized to be 20 °C and 0.05 g in 50 mL. Read More
Water Res 2018 Dec 6;150:418-430. Epub 2018 Dec 6.
College of Environmental & Resource Sciences, Zhejiang University, Hangzhou, 310058, China; Ministry of Education Key Laboratory of Environment Remediation and Ecological Health, Zhejiang University, Hangzhou, 310058, China. Electronic address:
Accurate source identification is critical for optimizing water pollution control strategies. Although the dual stable isotope (N-NO/O-NO) approach has been widely applied for differentiating riverine nitrogen (N) sources, the relatively short-term (<1 yr) N-NO/O-NO records typically used in previous studies often hinders rigorous assessment due to high temporal variability associated with watershed N dynamics. Estimated contributions of legacy N sources in soils and groundwater to riverine N export by modeling approaches in many previous studies also lack validation from complementary information, such as multiple stable isotopes. Read More
Forensic Sci Int 2018 Dec 6;295:36-45. Epub 2018 Dec 6.
Jagiellonian University, Faculty of Chemistry, Gronostajowa 2, 30-387 Kraków, Poland.
Introduction: Although there is an observed decline in the number of new psychoactive substances entering the drug market, this phenomenon is still a significant public health problem. Synthetic cathinones are the second largest group of new substances and currently belong to the most frequently confiscated. Their availability and prevalence cause that they are often abused. Read More
J Mol Graph Model 2018 Nov 26;87:220-226. Epub 2018 Nov 26.
Department of Physics, University of the Free State, Bloemfontein, 9300, South Africa; Department of Chemistry, National Institute of Technology (NIT) Hamirpur, Himachal Pradesh 177005, India.
The influence of changing Ag concentration in a Ag-TiO nanocomposite system was investigated with molecular dynamics (MD) simulations for both a fixed as well as varying number of the surfactant MO adsorbed onto the nanocomposite. Density functional theory (DFT) simulations were performed to investigate the conditions for charge transfer from the MO surfactant via the highest occupied molecular orbitals (HOMO), lowest unoccupied molecular orbitals (LUMO) as well as the electrostatic potentials. It is observed in this study that the bonding mode of the surfactant contributes greatly to the observed Raman scattering enhancement. Read More
Comput Biol Chem 2018 Nov 27;78:178-189. Epub 2018 Nov 27.
Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, China. Electronic address:
PPARα and PPARγ play an important role in regulating glucose and lipid metabolism. The single and selective PPARα or PPARγ agonists have caused several side effects such as edema, weight gain and cardiac failure. In the recent years, the dual PPARs agonist development has become a hot topic in the antidiabetic medicinal chemistry field. Read More
Environ Pollut 2018 Dec 5;246:311-318. Epub 2018 Dec 5.
Area of Cardiometabolic and Renal Risk, Biomedical Research Institute Hospital Clinic of Valencia (INCLIVA), Valencia, Spain; Department of Environmental Health and Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institutes, Madrid, Spain.
Introduction: While several mechanisms may explain metal-related health effects, the exact cellular processes are not fully understood. We evaluated the association between leukocyte telomere length (LTL) and urine arsenic (ΣAs), cadmium (Cd) and tungsten (W) exposure in the Strong Heart Study (SHS, N = 1702) and in the Strong Heart Family Study (SHFS, N = 1793).
Methods: Urine metal concentrations were measured using ICP-MS. Read More
Environ Pollut 2018 Dec 7;246:303-310. Epub 2018 Dec 7.
National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 491 Anagawa, Inage, Chiba, 263-8555, Japan.
The marine environment is complex, and it is desirable to have measurements for seawater samples collected at the early stage after the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident to determine the impact of Fukushima-derived radionuclides on this environment. Here Pu isotopes in seawater collected 33-163 km from the FDNPP site at the very early stage after the accident were determined (May 2011, within two months after the accident). The distribution and temporal variation of Pu and Pu were studied. Read More
Environ Pollut 2018 Dec 8;246:294-302. Epub 2018 Dec 8.
Department of Scienze Chimiche e Geologiche, Università di Cagliari and INSTM, Cittadella Universitaria di Monserrato, 09042, Monserrato, Cagliari, Italy.
In this work PM was collected during winter and summer in a Sardinian village (Gonnostramatza, Italy) highly affected by biomass burning emissions. A multi-technique approach was adopted for the complete PM chemical characterization. The bulk characterization was performed by IC (Ion Chromatography), HPAEC (High-Performance Anion-Exchange Chromatography), TOT (Thermal Optical Transmittance) and ED-XRF (Energy-Dispersive X-Ray Fluorescence) while XPS (X-ray Photoelectron Spectroscopy) was used for the surface characterization. Read More
Environ Pollut 2018 Dec 7;246:274-283. Epub 2018 Dec 7.
Department of Civil & Environmental Engineering, University of Wisconsin-Madison, Madison, 53705, USA; Environmental Chemistry and Technology, University of Wisconsin-Madison, Madison, 53706, USA. Electronic address:
Two hundred sixty-three fine particulate matter (PM) samples were collected over fourteen months in Fresno and Bakersfield, California. Samples were analyzed for organic carbon (OC), elemental carbon (EC), water soluble organic carbon (WSOC), and 160 organic molecular markers. Chemical Mass Balance (CMB) and Positive Matrix Factorization (PMF) source apportionment models were applied to the results in order to understand monthly and seasonal source contributions to PM OC. Read More
Environ Pollut 2018 Dec 4;246:225-236. Epub 2018 Dec 4.
College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China; CAS Center for Excellence in Regional Atmospheric Environment, Chinese Academy of Sciences, Xiamen, 361021, China. Electronic address:
In the study, personal PM exposures and their source contributions were characterized for 159 subjects living in the Beijing Metropolitan area. The exposures and sources were examined as functions of residential location, season, vocation, cigarette smoking, and time spent outdoors. Sampling was performed for two categories of volunteers, guards and students, that lived in urban and suburban areas of Beijing. Read More
J Pharm Biomed Anal 2018 Dec 10;165:242-250. Epub 2018 Dec 10.
Institute of Chemistry, Saint-Petersburg State University, Universitetsky pr. 26, Petrodvorez, 198584, St. Petersburg, Russia; Institute of Macromolecular Compounds, Russian Academy of Sciences, Bolshoy pr. 31, 199004, St. Petersburg, Russia.
A series of rigid macroporous polymer layers differed by hydrophobic-hydrophilic properties was synthesized in situ in preliminary fabricated wells and applied as the platforms for protein biochips. Scanning electron microscopy, etalon porosimetry and BET analysis were used for materials characterization. The comparison of analytical efficiency of the developed platforms allowed for the choice of the most optimal polymer, as well as the evaluation of impact of material porous properties. Read More
Water Res 2018 Nov 28;151:1-7. Epub 2018 Nov 28.
Department of Biotechcnology, Delft University of Technology, Delft, the Netherlands. Electronic address:
Microbial biofilms can be both cause and cure to a range of emerging societal problems including antimicrobial tolerance, water sanitation, water scarcity and pollution. The identities of extracellular polymeric substances (EPS) responsible for the establishment and function of biofilms are poorly understood. The lack of information on the chemical and physical identities of EPS limits the potential to rationally engineer biofilm processes, and impedes progress within the water and wastewater sector towards a circular economy and resource recovery. Read More
Colloids Surf B Biointerfaces 2018 Dec 5;175:403-408. Epub 2018 Dec 5.
Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka, Osaka 560-8531, Japan. Electronic address:
The J-aggregate of chlorophyll a (Chla) functions as a light-harvesting antenna in natural systems. In this study, we employed the phospholipid membranes composed of longer-chain 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and shorter-chain 1,2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC), as a platform to induce Chla aggregates. The DMPC/DHPC assembly at the mixing ratio (q) = 1. Read More
Chemosphere 2018 Dec 6;219:748-755. Epub 2018 Dec 6.
Department of Chemistry, Sreegopal Banerjee College, Bagati, Magra, Hooghly, West Bengal, 712148, India. Electronic address:
A gram-negative bacterium designated as RTSB was isolated from a petroleum-contaminated soil competent of utilizing acenaphthene as the solitary source of carbon and energy. The strain RTSB was identified as a Sphingobacterium species based on the morphological, nutritional and biochemical features of the organism as well as 16S rRNA sequence analysis. By a combination of chromatographic and spectrometric techniques, different metabolites of the acenaphthene degradation pathway by the strain RTSB were isolated and identified, which indicate a novel acenaphthene degradation pathway involving 1-naphthoic acid. Read More
Chemosphere 2018 Dec 8;219:704-712. Epub 2018 Dec 8.
Marshall University Department of Chemistry, One John Marshall Dr., Huntington, WV, 25755, USA. Electronic address:
Herbicides may cause unexpected damage to non-target organisms as it is challenging to predict undesirable biotic interactions. Poast is a widely used herbicide formulation that contains sethoxydim and targets the acetyl-CoA carboxylase of perennial grasses. In this study, Chlorella vulgaris, a unicellular green microalga, was exposed to a 0. Read More
Chemosphere 2018 Dec 6;219:695-703. Epub 2018 Dec 6.
UNESCO UNITWIN/WiCop Department of Physical-Chemistry, University of Cádiz, Campus Río de San Pedro, 11510, Puerto Real, Cádiz, Spain.
A passive treatment plant, located in the Iberian Pyrite Belt (Huelva, Southwest Spain), was designed for acid mine drainage remediation. Since its installation, the improvement of water quality in terms of hydrochemical composition has been demonstrated successfully. However, according to the Water Framework Directive, the treated effluent must have ecological values for potential living. Read More
Chemosphere 2018 Nov 27;219:662-670. Epub 2018 Nov 27.
Institute of Biometeorology (IBIMET), National Research Council (CNR), Via G. Caproni 8, 50145 Florence, Italy.
The influence of biochar added to an agricultural soil on polycyclic aromatic hydrocarbon (PAH) levels, PAH diagnostic ratios and soil properties was investigated in a five-year field experiment. The experiment was carried out in an Italian vineyard and included two biochar treatments: 16.5 t ha of biochar applied in 2009 (soil B); 16. Read More
Chemosphere 2018 Nov 28;219:655-661. Epub 2018 Nov 28.
Key Laboratory of Environment and Health, Ministry of Education & Ministry of Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address:
Benzophenones (BPs) are widely used as ultraviolet absorbers and fragrance retention agents. Evidences from animal studies have suggested that exposure to BPs may affect fetal growth, but human data is limited and no study is concerning critical windows of BPs exposure throughout pregnancy in relation to fetal growth. We aimed to investigate the associations of prenatal exposure to BPs with birth size and examine the critical exposure windows of fetus development. Read More
Ecotoxicol Environ Saf 2018 Dec 14;170:495-501. Epub 2018 Dec 14.
State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, China. Electronic address:
Halogenated bisphenol A analogues (X-BPA) have been widely used in industrial production, such as flame retardant. Although BPA exposure was found to result in cytotoxicity, toxicity of X-BPA and molecular mechanism remain under-explored. In this study, we employed human breast cancer cell as a model to investigate the concentration-dependent toxicity and underlying mechanisms of tetrabromo bisphenol A (TBBPA) and tetrachloro bisphenol A (TCBPA). Read More
Acta Biomater 2018 Dec 14. Epub 2018 Dec 14.
College of Pharmaceutical Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, PR China. Electronic address:
In this study, an AIE-active polymer (FTP) was successfully prepared and employed to load anti-cancer drug doxorubicin (DOX) for self-indicating cancer therapy via dual FRET process. Our results demonstrated that the FTP polymer could self-assemble into nanoparticles (NPs) in aqueous solutions to give strong fluorescence emission via intramolecular FRET process. The DOX loaded FTP NPs (drug loading content: 21. Read More
Int J Biol Macromol 2018 Dec 14. Epub 2018 Dec 14.
School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
In this work, a biobased adsorbent (CMC-PAMA) consisting of sodium carboxymethyl cellulose, polyacrylic acid and polyacrylamide was prepared by a simple thermal crosslinking method for the removal of methylene blue (MB) and Pb (II) from aqueous solutions. The CMC-PAMA showed excellent static adsorption capacities for MB and Pb (II) of 1611.44 mg·g 840. Read More
Int J Biol Macromol 2018 Dec 14. Epub 2018 Dec 14.
Food Colloids Group, Department of Food Technology, Engineering and Nutrition, Faculty of Engineering LTH, Lund University, PO Box 124, S-221 00 Lund, Sweden. Electronic address:
Three Andean grains - amaranth (Amaranthus caudatus), quinoa (Chenopodium quinoa), canihua (Chenopodium pallidicaulle) - and two Andean roots starches - achira (Canna indica), maca (Lepidium meyenii) - were studied. Physicochemical properties such as granule size, crystallinity, pasting properties among other as well as structural properties such as root-mean-square radius (r), weight-average molar mass (M) and apparent density (ρ) were analyzed in order to evaluate the relation between them. Grains were similar in most of their characteristics as roots in their i. Read More
Nitric Oxide 2018 Dec 14. Epub 2018 Dec 14.
Institute of Biomolecular Chemistry, National Research Council, 80078, Pozzuoli, Naples, Italy.
Chronic cough is one of the most common and troublesome nonspecific respiratory symptom for which patients seek a general practitioner and specialist advice. It is conventionally defined as a cough lasting for more than 8 weeks. Exhaled nitric oxide has proven to be a specific biomarker capable to discriminate between differential diagnoses of chronic cough and simultaneously provide information about the response to specific treatment. Read More
Microb Pathog 2018 Dec 14. Epub 2018 Dec 14.
Department of Chemistry, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, Tamil Nadu, 613401, India. Electronic address:
In this paper, the self assembling properties of taurolipids were used to prepare stable copper nanoparticles (CuNPs), and demonstrated the ability of CuNPs to eradicate the biofilms formed by waterborne pathogens. The synthesized CuNPs display wine red color and exhibited surface plasmon resonance with a maximum at 590 nm. Transmission electron microscopy showed that the CuNPs are well-dispersed with spherical morphology and the size range between 5 and 12 nm. Read More
Exp Neurol 2018 Dec 14. Epub 2018 Dec 14.
Department of Pharmacology and Toxicology, University of Kansas, 5064 Malott Hall, 1251 Wescoe Hall Dr., Lawrence, KS 66045, USA. Electronic address:
Neuronal mitochondrial dysfunction and oxidative stress are key pathophysiologic mechanisms of diabetic peripheral neuropathy (DPN). KU-596 is a small molecule modulator of heat shock protein 90 (Hsp90) that can reverse clinically relevant measures of DPN in diabetic animal models. Mechanistically, drug efficacy requires Hsp70 and correlates with improving mitochondrial maximal respiratory capacity (MRC) and decreasing oxidative stress in diabetic sensory neurons. Read More
J Pharm Sci 2018 Dec 14. Epub 2018 Dec 14.
QOPNA, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address:
Montelukast (MLK), an oral anti-asthmatic drug with growing use, requires special care in formulation and storage to avoid its degradation by action of light and/or water. This work investigates the increase in the stability of montelukast as the effect of molecular encapsulation with gamma-cyclodextrin (γ-CD) by means of a solvent-free method, co-grinding. As a first step, a 1:1 preferred stoichiometry is established for this host-guest system using a combination of molecular modelling and the continuous variation method. Read More
Biochem Pharmacol 2018 Dec 14. Epub 2018 Dec 14.
Department of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistrasse 52 D-20246 Hamburg, Germany. Electronic address:
The inositol phosphates, InsP and InsP, have recently been identified as binding partners of fibrinogen, which is critically involved in hemostasis by crosslinking activated platelets at sites of vascular injury. Here, we investigated the putative physiological role of this interaction and found that platelets increase their InsP concentration upon stimulation with the PLC-activating agonists thrombin, collagen I and ADP and present a fraction of it at the outer plasma membrane. Cone and plate analysis in whole blood revealed that InsP specifically increases platelet aggregate size. Read More
Chem Phys Lipids 2018 Dec 14. Epub 2018 Dec 14.
Division of Chemistry, School of Pharmacy and Biological Sciences, University of Brighton, BN2 4GL, United Kingdom. Electronic address:
Cells contain high levels of macromolecular crowding; understanding how macromolecular crowding impacts the behaviour of biological systems can give new insights into biological phenomena and disease pathologies. In this study, we assess the effect of macromolecular crowding on the catalytic activity of the biomembrane binding protein phospholipase A (PLA). Using 3D-printed equilibrium dialysis chambers we show that macromolecular crowding increases the binding of PLA to lipid vesicles. Read More
Angew Chem Int Ed Engl 2018 Dec 17. Epub 2018 Dec 17.
In contrast to organic cages which are formed by exploiting dynamic covalent chemistry, such as boronic ester cages, imine cages or disulfide cages, those with a fully carbonaceous backbone are rarer. With the exception of alkyne metathesis based approaches, the vast majority of hydrocarbon cages needs to be synthesized by kinetic bond formation. This implies a multiple step synthesis and no correction mechanism in the final macrocyclization step - both responsible for low overall yields. Read More
Chemistry 2018 Dec 17. Epub 2018 Dec 17.
Heinrich-Heine-Universität Düsseldorf, Institut für Organische Chemie und Makromolekulare Chemie, Universitätsstrasse 1, 40225, Düsseldorf, GERMANY.
Twofold Buchwald-Hartwig aminations selectively furnish all three regioisomers of bisbenzothieno[1,4]thiazines and X-ray structure analyses and DFT calculations were corroborated for correlation of their electronic properties. All regioisomers outscore the parent compound phenothiazine with respect to a low lying oxidation potential and reversible redox activity. The anti-anti bisbenzothieno[3,2-b:2',3'-e][1,4]thiazines possess the lowest oxidation potentials in this series and display pronounced green luminescence in solution ("Phi"F ≈ 20%) and in the solid state. Read More
Physiol Rep 2018 Dec;6(24):e13926
Centre for Molecular and Medical Research, School of Medicine, Deakin University, Geelong, Australia.
The antioxidant Selenoprotein S (Seps1, Selenos) is an endoplasmic reticulum (ER)-resident protein associated with metabolic and inflammatory disease. While Seps1 is highly expressed in skeletal muscle, its mechanistic role as an antioxidant in skeletal muscle cells is not well characterized. In C2C12 myotubes treated with palmitate for 24 h, endogenous Seps1 protein expression was upregulated twofold. Read More
Chem Biodivers 2018 Dec 17. Epub 2018 Dec 17.
Univesity of Saskatchewan, Dept. of Chemistry, 110 Science Place, S7N 5C9, Saskatoon, CANADA.
Leaves of the plant species Isatis indigotica Fort. (Chinese woad) produce the metabolites tryptanthrin, indirubin and N-formylanthranilic acid upon spraying with an aq. solution of copper chloride but not after spraying with water. Read More
PLoS One 2018 17;13(12):e0208732. Epub 2018 Dec 17.
Department of Chemistry, University of Iowa, Iowa City, Iowa, United States of America.
Hydrogen sulfide (H2S) is a key gasotransmitter in agriculture and has been reported to increase the growth of plants in the first two weeks and to mitigate the effects of environmental stressors. GYY-4137 is widely used in these studies because it slowly releases H2S, but there is disagreement as to whether it requires enzymes to release H2S. In this article we describe the release of H2S in water without enzymes and that it releases H2S faster in organic solvents than in water or when mixed in topsoil. Read More
PLoS One 2018 17;13(12):e0208974. Epub 2018 Dec 17.
Division of Pediatric Gastroenterology, Hepatology and Nutrition, University Children's Hospital, Inselspital, University of Bern, Bern, Switzerland.
Background: Accurate classification of patients with inflammatory bowel disease into the subtypes ulcerative colitis (UC) and Crohn's disease (CD) is still a challenge, but important for therapy and prognosis.
Objectives: To evaluate the diagnostic utility of anti-neutrophil cytoplasmic antibodies specific for proteinase-3 (PR3-ANCA) for ulcerative colitis (UC) and the value of an antibody panel incorporating PR3-ANCA to differentiate between Crohn's disease (CD) and UC.
Study Design: In this cohort study, 122 pediatric and adolescent individuals were retrospectively included (61 IBD patients of two clinical centers, 61 non-IBD controls). Read More
Xenobiotica 2018 Dec 17:1-22. Epub 2018 Dec 17.
a Department of Surgery and Cancer, Faculty of Medicine , Imperial College London, South Kensington Campus , London , SW7 2AZ, United Kingdom.
1. The metabolic fate and urinary excretion of 2-bromophenol, a phenolic metabolite of bromobenzene, was investigated in male Sprague Dawley rats following single intraperitoneal doses at either 0, 100 or 200 mg/kg. 2. Read More
Drug Dev Ind Pharm 2018 Dec 17:1-40. Epub 2018 Dec 17.
a H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences , Karachi University , Karachi , 74200 , Pakistan.
Emergence of multidrug resistance (MDR) has limited the success of chemotherapeutic agents. Reversal of drugs efflux systems through combination therapy has got wider attention for increasing anticancer drugs efficacy. This study aims at co-encapsulation of Paclitaxel with Naringin in mixed polymeric micelles for enhanced anticancer activity of the drug. Read More
Future Med Chem 2018 Dec 17. Epub 2018 Dec 17.
Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44, West Culture Road, Ji'nan 250012, PR China.
Hedgehog (HH) signaling pathway plays vital roles in controlling embryonic cell fate and homeostatic, and becomes dormant in mature individuals, aberrant activation of HH signaling pathway is involved in a number of human cancers. Smoothened (SMO), a vital transducer of HH signaling pathway, attracts significant attentions in HH signaling pathway-related cancer therapy. The approval of SMO antagonists Vismodegib proves that SMO is a promising therapeutic target, and a number of SMO antagonists are reported since then. Read More
Org Lett 2018 Dec 17. Epub 2018 Dec 17.
Institute of Organic Chemistry, Faculty of Science and Mathematics , Eberhard-Karls University Tübingen , Auf der Morgenstelle 18 , 72076 Tübingen , Germany.
A general and efficient Ni-catalyzed coupling of challenging aryl chlorides and in situ generated aliphatic and aromatic thiolates is described. The employed on-cycle, air-stable defined Ni precatalysts allow for transformation of a broad scope of substrates. A variety of functional groups and heterocyclic motifs as well as structurally varied thiols are tolerated at unprecedented moderate catalyst loadings and reaction temperatures. Read More
Org Lett 2018 Dec 17. Epub 2018 Dec 17.
Institute of Organic Chemistry , Johannes Gutenberg University Mainz , Duesbergweg 10-14 , 55128 Mainz , Germany.
A resource saving protocol for the synthesis of 5-fluoromethyl-2-oxazolines by using electrochemistry has been realized. Thereby, a hypervalent iodine species I(III) is generated by anodic oxidation in the presence of EtN·5HF and mediates the cyclization of N-allylcarboxamide to 5-fluoromethyl-2-oxazoline. This method allows application to various substrates furnishing the 2-oxazolines with yields up to 68%. Read More
Org Lett 2018 Dec 17. Epub 2018 Dec 17.
Department of Chemistry, Metcalf Center for Science and Engineering , Boston University , 590 Commonwealth Avenue , Boston , Massachusetts 02215 , United States.
Anhydrous FeCl in the presence of 2,6-lutidine promotes the substrate-controlled enantioselective [4 + 2]-cycloaddition and crotylation reaction between an enantioenriched ( S, E)-crotyl silane and in situ generated ortho-quinone methides ( oQMs). The reaction produces both the chiral chroman and crotylation products in a ratio reflective of the electronic nature of the parent oQM with overall combined yields up to 96%. A ring-opening and elimination sequence was subsequently developed to provide direct access to the crotylation products, containing two contiguous tertiary carbon stereocenters, in good yields and enantioselectivities. Read More
Org Lett 2018 Dec 17. Epub 2018 Dec 17.
Department of Chemistry , Technical University of Denmark , 2800 Kgs. Lyngby , Denmark.
A copper-catalyzed route to α-substituted, primary benzylamines by C-H functionalization of alkylarenes is described. The method directly affords the amine hydrochloride salt. Catalyst loadings down to 0. Read More
Nano Lett 2018 Dec 17. Epub 2018 Dec 17.
Center for Nanochemistry, Beijing Science and Engineering Center for Nanocarbons, Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering , Peking University , Beijing 100871 , P. R. China.
The air-stable and high-mobility two-dimensional (2D) BiOSe semiconductor has emerged as a promising alternative that is complementary to graphene, MoS, and black phosphorus for next-generation digital applications. However, the room-temperature residual charge carrier concentration of 2D BiOSe nanoplates synthesized so far is as high as about 10-10 cm, which results in a poor electrostatic gate control and unsuitable threshold voltage, detrimental to the fabrication of high-performance low-power devices. Here, we first present a facile approach for synthesizing 2D BiOSe single crystals with ultralow carrier concentration of ∼10 cm and high Hall mobility up to 410 cm V s simultaneously at room temperature. Read More
Org Lett 2018 Dec 17. Epub 2018 Dec 17.
Henan Key Laboratory of Organic Functional Molecules and Drug Innovation, School of Chemistry and Chemical Engineering , Henan Normal University , Xinxiang , Henan 453007 , China.
An efficient route to construct chiral acyclic purine nucleoside analogues via dynamic kinetic resolution of α-purine substituted alkanoic acids is reported. Using ( S)-BTM as the catalyst, diverse chiral acyclic purine nucleoside analogues were obtained in moderate to good yields (up to 93%) and high enantioselectivities (up to 98% ee). Chiral acyclic purine nucleosides could be obtained from the esterified products via reduction reaction, which could then be transferred into Tenofovir analogues. Read More
J Phys Chem B 2018 Dec 17. Epub 2018 Dec 17.
For exploration of chemical and biological systems, the combined quantum mechanics and molecular mechanics (QM/MM) and machine learning (ML) models have been developed recently to achieve high accuracy and efficiency for molecular dynamics (MD) simulations. Despite its success on reaction free energy calculations, how to identify new configurations on insufficiently sampled regions during MD and how to update the current ML models with the growing database on-the-fly are both very important but still challenging. In this letter, we apply the QM/MM ML method to solvation free energy calculations and address these two challenges. Read More
Inorg Chem 2018 Dec 17. Epub 2018 Dec 17.
Department of Chemistry and Chemical Biology , Rutgers, The State University of New Jersey , 610 Taylor Road , Piscataway , New Jersey 08854 , United States.
Double-perovskite LuNiIrO was synthesized at high pressure (6 GPa) and high temperature (1300 °C). Synchrotron powder X-ray diffraction indicates that its structure is a monoclinic double perovskite (space group P2/ n) with a small, 11% Ni/Ir antisite disorder. X-ray absorption near-edge spectroscopy measurements established Ni and Ir formal oxidation states. Read More