4,630,651 results match your criteria Chemistry & biology[Journal]


Enzyme Instructed Self-assembly of Naphthalimide-dipeptide: Spontaneous Transformation from Nanosphere to Nanotubular Structures that Induces Hydrogelation.

Chem Asian J 2020 Jul 11. Epub 2020 Jul 11.

National Chiao Tung University, Materials Science and Engineering, 1001 University Rd., 30010, Hsinchu, TAIWAN.

Understanding the structure-morphology relationships of the self-assembled nanostructures is very crucial for developing the materials with the desired chemical and biological functions. Here, phosphate-based naphthalimide (NI) derivatives have been developed for the first time to study the enzyme instructed self-assembly process. Self-assembly of simple amino acid derivative NI-Y p resulted in non-specific amorphous aggregates in the presence of alkaline phosphatase enzyme. Read More

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http://dx.doi.org/10.1002/asia.202000575DOI Listing

A natural BACE1 and GSK3β dual inhibitor Notopterol effectively ameliorates the cognitive deficits in APP/PS1 Alzheimer's mice by attenuating amyloid-β and tau pathology.

Clin Transl Med 2020 Jul 11. Epub 2020 Jul 11.

Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.

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http://dx.doi.org/10.1002/ctm2.50DOI Listing

Coupling Wireless Bipolar Ultramicroelectrode with Nano-electrospray Ionization Mass Spectrometry: Insights into the Ultrafast Initial Step of Electrochemical Reactions.

Angew Chem Int Ed Engl 2020 Jul 11. Epub 2020 Jul 11.

Najing University, Chemistry, Xianlin Ave. 163, , 210023, Nanjing, CHINA.

We report a new mass spectrometric method for detecting electrogenerated intermediates. This approach is based on simultaneous activation of electrospray ionization and redox reaction on a wireless bipolar ultramicroelectrode, which is fabricated in the tip of a quartz nanopipette. The hollow structure of the ultramicroelectrode permits rapid transferring the transient species from electrode-electrolyte interfaces into gas phase for mass spectrometric identification on the time scale of microseconds. Read More

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http://dx.doi.org/10.1002/anie.202008577DOI Listing

NAFLD is related to Postprandial Triglyceride-enrichment of HDL Particles in Association with Endothelial and HDL Dysfunction.

Liver Int 2020 Jul 11. Epub 2020 Jul 11.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands.

NAFLD is closely related with the metabolic syndrome (MetS) and increased risk of cardiovascular disease. Liver fat associates with postprandial hypertriglyceridemia, potentially contributing to triglyceride-enrichment of high-density-lipoproteins (HDL-TG), and subsequent HDL-dysfunction. We assessed liver fat by MR-spectroscopy, and its association with HDL physiochemical properties, and endothelial function, measured as flow-mediated dilation (FMD), before and following 3 consecutive meals, in 36 men with type 2 diabetes (T2DM), with the MetS, and controls. Read More

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http://dx.doi.org/10.1111/liv.14597DOI Listing

Guest-Responsive Reversible Electron Transfer in a Crystalline Porous Framework Supported by Dynamic Building Node.

Angew Chem Int Ed Engl 2020 Jul 11. Epub 2020 Jul 11.

Jawaharlal Nehru Centre for Advanced Scientfic Research, Chemistry and Physics of Materials Unit, Jakkur, 560 064, Bangalore, INDIA.

Spatial organization of electron donor-acceptor (D-A) supramolecular assembly is critical to the photophysical processes involved in solar energy conversion systems. Subtle variation in geometry, i.e. Read More

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http://dx.doi.org/10.1002/anie.202008189DOI Listing

Controlling mirror symmetry breaking and network formation in liquid crystalline cubic, isotropic liquid and crystalline phases of benzil-based polycatenars.

Chemistry 2020 Jul 11. Epub 2020 Jul 11.

University Halle, Chemistry, Organic Chemistry, Kurt-Mothes Str. 2, 06120, Halle/Saale, GERMANY.

Spontaneous development of chirality in systems composed of achiral molecules is important for new routes to asymmetric synthesis, chiral superstructures and materials, as well as for the understanding of the mechanisms of emergence of prebiotic chirality. Herein it is shown that the 4,4'-diphenylbenzil unit is a universal transiently chiral bent building block for the design of multi-chained (polycatenar) rod-like molecules capable of forming a wide variety of helically twisted network structures in the liquid, the liquid crystalline (LC) and the crystalline state. Single polar substituents at the apex of tricatenar molecules support the formation of the achiral (racemic) cubic double network phase with Ia d symmetry and relatively small twist along the networks. Read More

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http://dx.doi.org/10.1002/chem.202002869DOI Listing

High-protein diet more effectively reduces hepatic fat than low-protein diet despite lower autophagy and FGF21 levels.

Liver Int 2020 Jul 11. Epub 2020 Jul 11.

Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, 14558, Germany.

Background And Aims: Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent and nutrition intervention remains the most important therapeutic approach for NAFLD. Our aim was to investigate whether low- (LP) or high-protein (HP) diets are more effective in reducing liver fat and reversing NAFLD and which mechanisms are involved.

Methods: 19 participants with morbid obesity undergoing bariatric surgery were randomized into two hypocaloric (1500-1600 kcal/day) diet groups, a low protein (10E% protein) and a high protein (30E% protein), for three weeks prior to surgery. Read More

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http://dx.doi.org/10.1111/liv.14596DOI Listing

Tuning Electrical- and Photo-Conductivity by Cation Exchange within a Redox-Active Tetrathiafulvalene-Based Metal-Organic Framework.

Angew Chem Int Ed Engl 2020 Jul 11. Epub 2020 Jul 11.

Nanjing University, School of Chemistry and Chemical Engineering, Han Kou Road 22, 210093, Nanjing, CHINA.

To activate electronic and optical functions of the redox-active metal-organic framework, (Me 2 NH 2 )[In III (TTFTB)]·0.7C 2 H 5 OH· DMF (Me 2 NH 2 @ 1, TTFTB = tetrathiafulvalene-tetrabenzoate, DMF = N,N -dimethylformamide), has been exchanged by tetrathiafulvalenium (TTF •+ ) and N,N ' -dimethyl- 4,4 ' -bipyridinium (MV 2+ ). These cations provide electron carriers and photosensitivity. Read More

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http://dx.doi.org/10.1002/anie.202008941DOI Listing

Synthesis of antiviral perfluoroalkyl derivatives of teicoplanin and vancomycin.

ChemMedChem 2020 Jul 11. Epub 2020 Jul 11.

Debreceni Egyetem, Pharmaceutical Chemistry, HUNGARY.

The limited scope of antiviral drugs and increasing problem of antiviral drug resistance represent a global health threat. Glycopeptide antibiotics and their lipophilic derivatives have emerged as relevant inhibitors of diverse viruses. Here, we describe a new strategy for the synthesis of dual hydrophobic and lipophobic derivatives of glycopeptides, to produce selective antiviral agents without membrane-disrupting activity. Read More

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http://dx.doi.org/10.1002/cmdc.202000260DOI Listing

Metabolic implication of tigecycline as an efficacious second-line treatment for sorafenib-resistant hepatocellular carcinoma.

FASEB J 2020 Jul 11. Epub 2020 Jul 11.

Institute of Pharmacy, Center for Public Health, Paracelsus Medical University, Salzburg, Austria.

Sorafenib represents the current standard of care for patients with advanced-stage hepatocellular carcinoma (HCC). However, acquired drug resistance occurs frequently during therapy and is accompanied by rapid tumor regrowth after sorafenib therapy termination. To identify the mechanism of this therapy-limiting growth resumption, we established robust sorafenib resistance HCC cell models that exhibited mitochondrial dysfunction and chemotherapeutic crossresistance. Read More

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http://dx.doi.org/10.1096/fj.202001128RDOI Listing

Tuning the adsorption selectivity of ZIF-8 by amorphization.

Chemistry 2020 Jul 11. Epub 2020 Jul 11.

Ningbo University, The School of Materials Science and Chemical Engineering, Fenghua Road 818#, 315211, Ningbo, CHINA.

Amorphous metal-organic frameworks (amMOFs) with partial collapsed structure present a new category of porous hybrid materials. Herein, a solid-state amorphization of ZIF-8 was achieved by mechanical compression at 0.75 GPa. Read More

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http://dx.doi.org/10.1002/chem.202001249DOI Listing

The Impact of Leaving Group Anomericity on the Structure of Glycosyl Cations of Protected Galactosides.

Chemphyschem 2020 Jul 11. Epub 2020 Jul 11.

Freie Universitat Berlin, Institute of Chemistry and Biochemistry, Takustrasse 3, 14195, Berlin, GERMANY.

It has been reported that fragments produced by glycosidic bond breakage in mass spectrometry-based experiments can retain a memory of their anomeric configuration, which has major implications for glycan sequencing. Here we use cryogenic vibrational spectroscopy and ion mobility-mass spectrometry to study the structure of B-type fragments of protected galactosides. Cationic fragments were generated from glycosyl donors carrying trichloroacetimidate or thioethyl leaving groups of different anomeric configuration. Read More

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http://dx.doi.org/10.1002/cphc.202000473DOI Listing

Protective efficacy of phenoxyacetyl oxazolidine derivatives as safeners against nicosulfuron toxicity in maize.

Pest Manag Sci 2020 Jul 11. Epub 2020 Jul 11.

Department of Applied Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin, 150030, China.

Background: Herbicide safeners mitigate crop damage without reducing herbicide efficacy. Here, the protective effects of phenoxyacetyl oxazolidine derivatives as potential safeners were evaluated with a view toward reducing injury caused by sulfonylurea herbicide nicosulfuron to sensitive maize varieties.

Results: Growth indices demonstrated that the bioactivity of compound 9 (N-phenoxyacety-2-methyl-2,4-diethyl-1,3-oxazolidine) was superior to that of R-28725 and all other compounds tested. Read More

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http://dx.doi.org/10.1002/ps.6005DOI Listing

Universal Access to Two-Dimensional Mesoporous Heterostructures via Micelle-Directed Interfacial Assembly.

Angew Chem Int Ed Engl 2020 Jul 11. Epub 2020 Jul 11.

The University of Queensland, School of Chemical Engineering and Australian Institute for Bioengineering and Nanotechnology (AIBN), Saint Lucia, 4072, Brisbane, AUSTRALIA.

Two-dimensional (2D) mesoporous heterostructures combining ultrathin nanosheet morphology, periodic porous surface structures and diverse hybrid compositions have recently emerged and become increasingly important for renewable energy storage and electronics. However, it remains a great challenge to develop a universal method to prepare 2D mesoporous heterostructures. Here, we report a composite micelle-directed interfacial assembly method to synthesize vertical heterostructures with ultrathin 2D material and two surrounding mesoporous monolayers assembled on both sides. Read More

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http://dx.doi.org/10.1002/anie.202007063DOI Listing

Synergy of Electrostatic and π-π Interactions in the Realization of Nanoscale Artificial Photosynthetic Model Systems.

Angew Chem Int Ed Engl 2020 Jul 11. Epub 2020 Jul 11.

Universidad Autonoma de Madrid, Organic Chemistry, SPAIN.

In the scientific race to build up photoactive electron donor-acceptor systems with increasing efficiencies, little is known about the interplay of their building blocks when integrated into supramolecular nanoscale arrays, particularly in aqueous environments. Here, we describe an aqueous donor-acceptor ensemble whose emergence as a nanoscale material renders it remarkably stable and efficient. We have focused on a tetracationic zinc phthalocyanine (ZnPc) featuring pyrenes, which shows an unprecedented mode of aggregation, driven by subtle cooperation between electrostatic and π-π interactions. Read More

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http://dx.doi.org/10.1002/anie.202006014DOI Listing

Dealkenylative Alkenylation: Formal σ-Bond Metathesis of Olefins.

Angew Chem Int Ed Engl 2020 Jul 11. Epub 2020 Jul 11.

University of California Los Angeles, Chemistry and Biochemistry, UNITED STATES.

Dealkenylative alkenylation of alkene C(sp3)-C(sp2) bonds has been an unexplored area for C-C bond formation. Herein, we report 64 examples of β-alkylated styrene derivatives synthesized through the reactions of readily accessible feedstock olefins with β-nitrostyrenes through ozone/Fe(II)-mediated radical substitution. These reactions proceed with good efficiency and high stereoselectivity under mild conditions and tolerate an array of functional groups. Read More

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http://dx.doi.org/10.1002/anie.202005267DOI Listing

Addressing the structural complexity of fluorinated glucose analogues: Insight into lipophilicities and solvation effects.

Chemistry 2020 Jul 11. Epub 2020 Jul 11.

Universite Laval, Chemistry, 1045, av de la Medecine, Pavillon Alexandre-Vachon, Chemistry Department, Room VCH-2240D, G1V0A6, Quebec, CANADA.

In this work, we synthesized all mono-, di-, and trifluorinated glucopyranose analogues at positions C-2, C-3, C-4, and C-6. This systematic investigation allowed us to perform direct comparison of 19 F resonances of fluorinated glucose analogues and also to determine their lipophilicities. Compounds with a fluorine atom at C-6 are usually the most hydrophilic whereas those with vicinal polyfluorinated motifs are the most lipophilic. Read More

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http://dx.doi.org/10.1002/chem.202002825DOI Listing

Anchoring Ba(II) to Pd/HyWO3-x Nanowires Promote the Photocatalytic Reverse Water Gas Shift Reaction.

Chemistry 2020 Jul 11. Epub 2020 Jul 11.

University of Toronto, Chemistry, CANADA.

A conformal coating of Ba(II) on the surface of Pd/HyWO3-x nanowires was developed using a solution-phase atomic layer deposition process. The proceedure involves generation of Brønsted surface OH sites by H2 spillover on Pd/WO3, which can then hydrolytically condense with Ba(OEt)2 to produce surface Ba(II). At just 0. Read More

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http://dx.doi.org/10.1002/chem.202002975DOI Listing

Photophysical properties of DCM revisited: fluorescence vs. photoisomerization.

Chemistry 2020 Jul 11. Epub 2020 Jul 11.

CNRS, Université Paris-Saclay, ENS Paris-Saclay, PPSM Laboratory, 4 av des Sciences, 91190, Gif-sur-Yvette, FRANCE.

Although the 4-dicyanomethylene-2-methyl-6-(p-dimethylamino-styryl)-4H-pyran (DCM) has been known for many decades as a bright and photostable fluorophore, used for a wide variety of applications in chemistry, biology and physics, only little attention has been paid so far on the presence of multiple isomers and conformers, namely s-trans-(E), s-cis-(E), s-trans-(Z), and s-cis-(Z). Especially, the light-induced E-Z isomerization plays a great role on the overall photophysical properties of DCM. Here we report the full description of a photoswitchable DCM derivative by a combination of structural, theoretical and spectroscopic methods. Read More

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http://dx.doi.org/10.1002/chem.202002828DOI Listing

Fragmentation Mechanism of White Phosphorus: A Theoretical Insight into Multiple Cleavage/Formation of P-P and P-C Bonds.

Chemistry 2020 Jul 11. Epub 2020 Jul 11.

Dalian University of Technology, School of Chemical Engineering, CHINA.

Molecular-level understanding of metal-mediated white phosphorus (P 4 ) activation is meaningful but challenging because of its direct relevance to conversion of P 4 into useful organophosphorus compounds as well as the complicated and unforeseeable cleavage process of P-P bonds. The related study, however, has still rarely been achieved to date. We reported here a theoretical insight into step-by-step process of three P-P bond cleavage/four P-C bond formation for [P 3 +P 1 ]-fragmentation of P 4 mediated by lutetacyclopentadienes. Read More

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http://dx.doi.org/10.1002/chem.202002338DOI Listing

Metamizole but not Ibuprofen reduces the plasma concentration of sertraline - Implications for the concurrent treatment of pain and depression/anxiety disorders.

Br J Clin Pharmacol 2020 Jul 11. Epub 2020 Jul 11.

Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Germany.

Aim: Comorbidity of pain and depression or anxiety is a challenging clinical phenomenon, often requiring the concurrent application of antidepressant and analgesic drugs. Growing evidence suggests that the analgesic metamizole exhibits cytochrome P450 inducing properties. In the present study, we assessed the impact of metamizole and ibuprofen on plasma concentrations of the selective serotonin reuptake inhibitor sertraline. Read More

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http://dx.doi.org/10.1111/bcp.14471DOI Listing

The natural compound Cirsitakaoside enhances antiviral innate responses against vesicular stomatitis virus in vitro and in vivo.

Int Immunopharmacol 2020 Jul 8;86:106783. Epub 2020 Jul 8.

Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Immunology, Shenzhen University School of Medicine, Shenzhen 518060, China. Electronic address:

Cirsitakaoside, isolated and purified from the stems and leaves of Premna szemaoensis and Macaranga denticulata, is a natural compound with potential anti-inflammatory effects. However, the role of Cirsitakaoside in antiviral activity and the underlying mechanism remains largely unknown. In this study, we aimed to identify whether Cirsitakaoside has antiviral activity and investigated the underlying mechanisms. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106783DOI Listing

Limonene, a food additive, and its active metabolite perillyl alcohol improve regeneration and attenuate neuropathic pain after peripheral nerve injury: Evidence for IL-1β, TNF-α, GAP, NGF and ERK involvement.

Int Immunopharmacol 2020 Jul 8;86:106766. Epub 2020 Jul 8.

Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, São Cristóvão, SE 49100-000, Brazil; Franco-Brazilian Network on Natural Products (FB2NP), Brazil. Electronic address:

Background: Limonene (LIM) and its main metabolite perillyl alcohol (POH) are ingredients found in food with promising chemical entities due to their pharmacological profile. In this study, we hypothesized that LIM and POH are two molecules capable of accelerating the regenerative process and alleviating neuropathic pain.

Methods: Animals were treated daily (LIM, POH and saline) for 28 days and during this period evaluated for mechanical hyperalgesia, astrocyte participation by immunofluorescence for GFAP, and ELISA was used to quantify IL-1β and TNF-α in the spinal cord. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106766DOI Listing

Photocaged functional nucleic acids for spatiotemporal imaging in biology.

Curr Opin Chem Biol 2020 Jul 8;57:95-104. Epub 2020 Jul 8.

Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, United States; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, United States; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, United States; DOE Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, United States. Electronic address:

Imaging of species in living organisms with high spatiotemporal resolution is essential for understanding biological processes. While functional nucleic acids (FNAs), such as catalytic nucleic acids and aptamers, have emerged as effective sensors for a wide range of molecules, photocaged control of these FNAs has played a key role in translating them into bioimaging agents with high spatiotemporal control. In this review, we summarize methods and results of photocaged FNAs based on photolabile modifications, photoisomerization, and photothermal activation. Read More

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http://dx.doi.org/10.1016/j.cbpa.2020.05.003DOI Listing

Quantifying DNA damage induced by ionizing radiation and hyperthermia using single DNA molecule imaging.

Transl Oncol 2020 Jul 8;13(10):100822. Epub 2020 Jul 8.

Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden. Electronic address:

Ionizing radiation (IR) is a common mode of cancer therapy, where DNA damage is the major reason of cell death. Here, we use an assay based on fluorescence imaging of single damaged DNA molecules isolated from radiated lymphocytes, to quantify IR induced DNA damage. The assay uses a cocktail of DNA-repair enzymes that recognizes and excises DNA lesions and then a polymerase and a ligase incorporate fluorescent nucleotides at the damage sites, resulting in a fluorescent "spot" at each site. Read More

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http://dx.doi.org/10.1016/j.tranon.2020.100822DOI Listing

Exoenzyme C3 transferase lowers actin cytoskeleton dynamics, genomic stability and survival of malignant melanoma cells under UV-light stress.

J Photochem Photobiol B 2020 Jul 2;209:111947. Epub 2020 Jul 2.

Biomolecular Systems Signaling Laboratory, Department of Biochemistry, Institute of Chemistry, University of Sao Paulo, Sao Paulo, SP, Brazil. Electronic address:

Actin cytoskeleton remodeling is the major motor of cytoskeleton dynamics driving tumor cell adhesion, migration and invasion. The typical RhoA, RhoB and RhoC GTPases are the main regulators of actin cytoskeleton dynamics. The C3 exoenzyme transferase from Clostridium botulinum is a toxin that causes the specific ADP-ribosylation of Rho-like proteins, leading to its inactivation. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2020.111947DOI Listing

Pamiparib is a potent and selective PARP inhibitor with unique potential for the treatment of brain tumor.

Neoplasia 2020 Jul 8;22(9):431-440. Epub 2020 Jul 8.

Department of In Vivo Pharmacology, BeiGene (Beijing) Co., Ltd., Beijing, PR China. Electronic address:

Pamiparib, an investigational Poly (ADP-ribose) polymerase (PARP) inhibitor in clinical development, demonstrates excellent selectivity for both PARP1 and PARP2, and superb anti-proliferation activities in tumor cell lines with BRCA1/2 mutations or HR pathway deficiency (HRD). Pamiparib has good bioavailability and is 16-fold more potent than olaparib in an efficacy study using BRCA1 mutated MDA-MB-436 breast cancer xenograft model. Pamiparib also shows strong anti-tumor synergy with temozolomide (TMZ), a DNA alkylating agent used to treat brain tumors. Read More

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http://dx.doi.org/10.1016/j.neo.2020.06.009DOI Listing

Biochar affects the dissipation of antibiotics and abundance of antibiotic resistance genes in pig manure.

Bioresour Technol 2020 Jul 6;315:123782. Epub 2020 Jul 6.

Soil Science, University of Trier, Trier, Germany. Electronic address:

Manure from medicated livestock contains pharmaceutical antibiotics and antibiotic resistance genes (ARGs). Bioavailable antibiotics trigger further ARGs amplification during manure storage. It was tested whether biochar lowers the bioavailability of the antibiotics sulfamethazine (SMZ), ciprofloxacin (CIP), oxytetracycline (OTC) and florfenicol (FF) in manure and the amplification of sul1 and tet(W) ARGs. Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123782DOI Listing

Recent advances in chemistry and bioactivity of marine cyanobacteria Moorea species.

Eur J Med Chem 2020 May 31;201:112473. Epub 2020 May 31.

Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, 315832, China. Electronic address:

Cyanobacteria are one of the oldest creatures on earth, originated 3.5-3.3 billion years ago, and are distributed all over the world, including freshwater ponds and lakes, hot springs, and polar ice, especially in tropical and subtropical marine locations. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112473DOI Listing

Kojic acid-natural product conjugates as mushroom tyrosinase inhibitors.

Eur J Med Chem 2020 Jun 16;201:112480. Epub 2020 Jun 16.

Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

As part of our effort to develop potential tyrosinase inhibitors, we have conjugated the well-known tyrosinase inhibitor kojic acid (KA) with several phenolic natural products such as umbelliferone, sesamol, thymol, carvacrol, eugenol, isoeugenol, vanillin, isovanillin, and apocynin that some reports have shown their activity on tyrosinase enzyme. The designed compounds were synthesized using click reaction and 1,2,3-triazole formation. All compound showed potent anti-tyrosinase activity significantly higher than KA. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112480DOI Listing

Alkyl chain length affecting uptake of imidazolium based ionic liquids by ryegrass (Lolium perenne L.).

J Hazard Mater 2020 Jul 2;401:123376. Epub 2020 Jul 2.

CAS Key Laboratory of Urban Pollutant Conversion, Department of Environmental Science and Engineering, University of Science and Technology of China, Hefei 230026, China. Electronic address:

Imidazolium based ionic liquids (ILs) have been extensively used in the various industrial fields, however, the dependence of their structure on toxicity and bioavailability by plants is not clear. Thus, in this study, uptake of imidazolium based ILs with different alkyl chain lengths (e.g. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123376DOI Listing

An efficient broad spectrum-driven carbon and oxygen co-doped g-CN for the photodegradation of endocrine disrupting: Mechanism, degradation pathway, DFT calculation and toluene selective oxidation.

J Hazard Mater 2020 Jun 27;401:123309. Epub 2020 Jun 27.

Institute for Energy Research, Jiangsu University, Zhenjiang 212013, PR China. Electronic address:

In this study, a new type of carbon and oxygen co-doped g-CN (PACN) was successfully synthesized by a one-step thermal polymerization method for the photodegradation of Bisphenol A (BPA) and selective oxidation of toluene to benzaldehyde. The degradation rate of BPA was 23.58 times higher than that of pristine g-CN and the efficiency benzaldehyde formation rate without the need of any solvent increased to 5. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123309DOI Listing

Recyclable aqueous metal adsorbent: Synthesis and Cu(II) sorption characteristics of ternary nanocomposites of FeO nanoparticles@graphene-poly-N-phenylglycine nanofibers.

J Hazard Mater 2020 Jun 22;401:123283. Epub 2020 Jun 22.

Department of Nanotechnology and Advanced Materials Engineering, Sejong University, Gwangjin-gu, Seoul, 05006, Republic of Korea; Graphene Research Institute (GRI) & GRI-TPC International Research Center, Sejong University, Gwangjin-gu, Seoul, 05006, Republic of Korea. Electronic address:

Metal pollutant adsorbents are an essential material platform for sustainable environmental remediation, but the adsorbents are typically disposable after sorption, which secondarily contaminates the environment. We report on recyclable Cu(II) adsorbent of deprotonated poly-N-phenylglycine nanofibers (d-PPG NFs)-grafted reduced graphene oxide (rGO) sheets intercalated with FeO nanoparticles (NPs), which are synthesized via wet chemical process. The adsorption performances of ternary FeO NPs@rGO-d-PPG NFs and binary FeO NPs@rGO composites are compared, and the ternary ones exhibit much higher Cu-adsorption capacity than binary ones under diverse pH conditions due to both high specific surface area and high cationic affinity of d-PPG NFs that follow the Freundlich adsorption model. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123283DOI Listing

8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi.

Eur J Med Chem 2020 Jul 8;202:112558. Epub 2020 Jul 8.

Aix Marseille Univ, CNRS, ICR UMR 7273, Equipe Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, 27 Boulevard Jean Moulin, CS30064, 13385, Marseille Cedex 05, France.

An antikinetoplastid pharmacomodulation study was done at position 8 of a previously identified pharmacophore in 3-nitroimidazo[1,2-a]pyridine series. Twenty original derivatives bearing an alkynyl moiety were synthesized via a Sonogashira cross-coupling reaction and tested in vitro, highlighting 3 potent (40 nM ≤ EC blood stream form≤ 70 nM) and selective (500 ≤ SI ≤ 1800) anti-T. brucei brucei molecules (19, 21 and 22), in comparison with four reference drugs. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112558DOI Listing

Fabrication of electrochemical biosensor composed of multi-functional DNA/rhodium nanoplate heterolayer for thyroxine detection in clinical sample.

Colloids Surf B Biointerfaces 2020 Jul 2;195:111240. Epub 2020 Jul 2.

Department of Chemical Engineering, Kwangwoon University, Wolgye-dong, Nowon-gu, Seoul, 01899, Republic of Korea. Electronic address:

Thyroxine (T4) contains four iodine atoms and is a major thyroid hormone synthesized in the thyroid gland. Abnormal levels of T4 in the body cause various endocrine diseases. The present study describes the fabrication of an electrochemical biosensor composed of a multi-functional DNA structure/rhodium nanoplates heterolayer for precise detection of T4 concentration. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.111240DOI Listing

Disruptions and re-establishment of the calcium-bicarbonate equilibrium in freshwaters.

Sci Total Environ 2020 Jul 4;743:140626. Epub 2020 Jul 4.

School of Earth and Climate Sciences, University of Maine, Orono, ME 04469, USA. Electronic address:

During recent decades, increasing anthropogenic activities have affected natural ionic composition, including the strongest and most common relationship between ionic concentrations in the majority of natural global freshwaters, i.e., the Ca-ANC (acid neutralizing capacity) equilibrium. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140626DOI Listing

Fungal bioremediation of diuron-contaminated waters: Evaluation of its degradation and the effect of amendable factors on its removal in a trickle-bed reactor under non-sterile conditions.

Sci Total Environ 2020 Jul 4;743:140628. Epub 2020 Jul 4.

Departament d'Enginyeria Química, Biològica i Ambiental, Escola d'Enginyeria, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.

The occurrence of the extensively used herbicide diuron in the environment poses a severe threat to the ecosystem and human health. Four different ligninolytic fungi were studied as biodegradation candidates for the removal of diuron. Among them, T. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140628DOI Listing

Complexation of Fe(III)/Catechols in atmospheric aqueous phase and the consequent cytotoxicity assessment in human bronchial epithelial cells (BEAS-2B).

Ecotoxicol Environ Saf 2020 Jul 8;202:110898. Epub 2020 Jul 8.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.

Recent research has shown that the complexation of metals-organics plays an important role in atmospheric particulate matter, whose health effects should be taken into account. This work investigates the interactions between catechols (CAs), i.e. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110898DOI Listing
July 2020
2.762 Impact Factor

Sealed pre-carbonization to regulate the porosity and heteroatom sites of biomass derived carbons for lithium-sulfur batteries.

J Colloid Interface Sci 2020 Jul 1;579:667-679. Epub 2020 Jul 1.

School of Environment, Henan Normal University, Xinxiang, Henan 453007, PR China. Electronic address:

Ultrathin carbon sheets with high surface area, abundant mesoporous structure and rich N, O heteroatom doping sites were prepared from puffed rice through unique sealed pre-carbonization. By utilizing them as cathode materials for lithium-sulfur batteries, the in-operando Raman spectra and electrochemical tests indicated that the polysulfides shuttling effect could be substantially suppressed by the physical confinement and chemical adsorption due to these structural advantages. In addition, the well-developed hierarchical porous structure and ultrathin thickness were found to enhance the mass diffusion in the electrode, which increased the ion conductivity within the carbon framework. Read More

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http://dx.doi.org/10.1016/j.jcis.2020.06.068DOI Listing

Design and evaluation a kind of functional biomaterial for bone tissue engineering: Selenium/mesoporous bioactive glass nanospheres.

J Colloid Interface Sci 2020 Jul 1;579:654-666. Epub 2020 Jul 1.

College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, People's Republic of China. Electronic address:

Conventional treatments of bone tumor involve removal followed by radiation and chemotherapeutic drugs that may have limitations and cause secondary damage. The development of functional filling biomaterial has led to a new strategy for tumor therapy. In this study, a novel therapeutic ion selenium doped mesoporous bioactive glasses (Se/MBG) nanospheres were successfully synthesized by a facile sol-gel technique using cetyl trimethyl ammonium bromide (CTAB) as the template, which had uniform spherical morphology (≈ 400 nm), high surface area (>400 m/g) and mesopore volume (≈0. Read More

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http://dx.doi.org/10.1016/j.jcis.2020.06.122DOI Listing

Virtual Special Issue in memory of Hans Lyklema (1930-2017).

Adv Colloid Interface Sci 2020 Jun 30;282:102201. Epub 2020 Jun 30.

Physical Chemistry and Soft Matter, Wageningen University, the Netherlands.

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http://dx.doi.org/10.1016/j.cis.2020.102201DOI Listing

Recent advances in multitarget-directed ligands targeting G-protein-coupled receptors.

Drug Discov Today 2020 Jul 8. Epub 2020 Jul 8.

Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23298, USA. Electronic address:

Mounting evidence indicates that single-target drugs might be inadequate to achieve satisfactory therapeutic effects on complex diseases. Recently, increasing attention has been paid to developing drugs that can manipulate multiple targets to generate beneficial effects through potential synergy. G-protein-coupled receptors (GPCRs) become desirable targets for developing multitarget-directed ligands (MTDLs) because of their crucial roles in the pathophysiology of various human diseases and the accessibility of druggable sites at the cell surface. Read More

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http://dx.doi.org/10.1016/j.drudis.2020.07.004DOI Listing

Exploring CYP2J2: lipid mediators, inhibitors and therapeutic implications.

Drug Discov Today 2020 Jul 8. Epub 2020 Jul 8.

Institute of Clinical Pharmacology, Pharmazentrum Frankfurt/ZAFES, University Hospital of Goethe-University, 60590 Frankfurt am Main, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Branch Translational Medicine & Pharmacology TMP, 60596 Frankfurt am Main, Germany; Fraunhofer Cluster of Excellence for Immune Mediated Diseases (CIMD), 60596 Frankfurt am Main, Germany.

In contrast to other drug-metabolizing cytochrome P (CYP) oxygenases, CYP2J2 shows considerable extrahepatic activity and is responsible for the olefin epoxidation of several polyunsaturated fatty acid (PUFA) precursors. The resulting epoxylipids act as signaling mediators and show a remarkable variety of biological functions. Recent studies suggest a role of selected CYP2J2-derived epoxylipids and their metabolites in chronic pain, as well as angiogenesis, hematopoiesis, metabolic disorders, and tumor growth. Read More

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http://dx.doi.org/10.1016/j.drudis.2020.07.002DOI Listing

The role of neuropeptides in learning: insights from C. elegans.

Int J Biochem Cell Biol 2020 Jul 8:105801. Epub 2020 Jul 8.

Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong and Illawarra Health and Medical Research Institute, NSW, 2522, Australia. Electronic address:

Learning is critical for survival as it provides the capacity to adapt to a changing environment. At the molecular and cellular level, learning leads to alterations within neural circuits that include synaptic rewiring and synaptic plasticity. These changes are mediated by signalling molecules known as neuromodulators. Read More

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http://dx.doi.org/10.1016/j.biocel.2020.105801DOI Listing

Theoretical study on resonance Raman spectra of meso-tetrakis(3,5-di-tertiarybutylphenyl)-porphyrin due to the second-order Herzberg-Teller mechanism.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 2;241:118659. Epub 2020 Jul 2.

Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Zhongguancun, Beijing 100190, People's Republic of China.

Using quantum chemistry computations TDDFT//B3LYP/6-31G(d), we study resonance Raman spectra of the Q band for meso-tetrakis(3,5-di-tertiarybutylphenyl)-porphyrin (HTBPP) molecule due to the Franck-Condon and non-Condon mechanisms including the Herzberg-Teller and second-order Herzberg-Teller terms. Generally, the Herzberg-Teller terms are large. However, for some vibrational modes, the second-order Herzberg-Teller terms are the strongest and dominate resonance Raman spectra, which may also impact on fluorescence and absorption spectra. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118659DOI Listing

Spectroscopic studies for the inclusion complexation of ketoprofen enantiomers with β-cyclodextrin.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 2;241:118674. Epub 2020 Jul 2.

Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia; Centre for Ionic Liquids, Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. Electronic address:

Inclusion complexes of R-ketoprofen and S-ketoprofen enantiomers with β-cyclodextrin (β-CD) in aqueous solution were studied using various spectroscopic techniques such as Raman, FTIR, UV and fluorescence. The different relative intensities and characteristic band shifts of the two enantiomers from Raman spectra suggests different interaction when complexed with β-CD. Raman experiments revealed a noticeable diminishing of the CC vibration and ring deformation, which indicate the embedding of ketoprofen inside the β-CD cavity. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118674DOI Listing

Stretching force constants as descriptors of energy and geometry of F···HF hydrogen bonds.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 3;241:118677. Epub 2020 Jul 3.

Institute of Chemistry, St. Petersburg State University, 26 Universitetskii pr., Petergof, St. Petersburg 198504, Russia. Electronic address:

In this work applicability of proton donor group stretching vibration force constants k and intermolecular stretching force constants k for evaluations of hydrogen bond strength and geometry are discussed. For a set of 30 complexes with F···HF hydrogen bonds in a wide range 0.5-48 kcal/mol by means of quantum chemical calculations equilibrium geometries, complexation energies, vibrational frequencies and corresponding force constants were calculated (MP2/aug-cc-pVTZ). Read More

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http://dx.doi.org/10.1016/j.saa.2020.118677DOI Listing

Simultaneous determination of cefixime and erdosteine in combined dosage form using validated spectrophotometric methods.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 27;241:118647. Epub 2020 Jun 27.

Researcher, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo 11562, Egypt.

Four accurate and precise spectrophotometric methods were developed and validated for the simultaneous determination of a binary mixture of cefixime (CEF) and erdosteine (ERD) without previous separation. Method A was first derivative ratio spectrophotometric method (DD) where the amplitudes at 310 and 315 nm and the amplitude at 248 nm were chosen to simultaneously estimate CEF and ERD, respectively. Method B depends on ratio difference spectrophotometry (RDSM), in which the difference in amplitudes at 325 and 326 nm on the ratio spectrum of the mixture was directly proportional to the concentration of CEF; independent of the interfering component. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118647DOI Listing

Synthesis, characterization, photoluminescence, antiproliferative activity, and DNA interaction of cadmium(II) substituted 4'-phenyl-terpyridine compounds.

J Inorg Biochem 2020 Jun 25;210:111165. Epub 2020 Jun 25.

School of Chemistry and Chemical Engineering, Guangxi University, 530004 Nanning, Guangxi, People's Republic of China; Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal. Electronic address:

A series of CdCl complexes (1a-1f and 2a-2c) with 4'-(substituted-phenyl)-2,2':6',2″-terpyridine compounds bearing hydrogen (L), p-methyl (L), p-phenyl (L), p-tolyl (L), p-carboxyl (L), p-fluoro (L), p-hydroxyl (L), m-hydroxyl (L) or o-hydroxyl (L), were prepared and characterized by H NMR, IR, elemental analysis and single crystal X-ray diffraction. All the compounds display interesting photoluminescent properties and different maximal emission peaks due to the difference of the substituent groups. The in vitro antiproliferative activities against four human carcinoma cell lines, A549, Bel-7402, Eca-109 and MCF-7, were investigated and cell viability studies indicate that the compounds have excellent results with the lowest IC values of 0. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2020.111165DOI Listing

Synthesis and enhanced antioxidant and membrane-protective activity of curcumin@AlOOH nanoparticles.

J Inorg Biochem 2020 Jul 2;210:111168. Epub 2020 Jul 2.

Institute of Biology, Komi Science Centre, Ural Branch of Russian Academy of Sciences, 167982, 28 Kommunisticheskaya St., Syktyvkar, Russia.

The ever increasing demand for nanoantioxidants with minimized toxicity dictates the necessity to develop new biocompatible materials. One promising approach is the immobilization of polyphenols on metal (oxy)hydroxide nanoparticles (NPs) that possess the desired chemical and colloidal stability while also allowing to dispose of the antioxidants more safely and effectively. In this paper we modify sol-gel synthesized γ-AlOOH NPs with curcumin molecules. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2020.111168DOI Listing
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