Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase.
BMC Biol 2016 08 9;14:65. Epub 2016 Aug 9.
Medical Research Council Mitochondrial Biology Unit, Wellcome Trust / MRC Building, Hills Road, Cambridge, CB2 0XY, UK.
Background: The biguanides are a family of drugs with diverse clinical applications. Metformin, a widely used anti-hyperglycemic biguanide, suppresses mitochondrial respiration by inhibiting respiratory complex I. Phenformin, a related anti-hyperglycemic biguanide, also inhibits respiration, but proguanil, which is widely used for the prevention of malaria, does not. Read More