4,286,992 results match your criteria Chemistry & biology[Journal]


Dental Follicle Stem Cells Ameliorate Lipopolysaccharide-Induced Inflammation by Secreting TGF-β3 and TSP-1 to Elicit Macrophage M2 Polarization.

Cell Physiol Biochem 2018 7;51(5):2290-2308. Epub 2018 Dec 7.

Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou,

Background/aims: Increasing evidence has demonstrated the novel roles of mesenchymal stem cells (MSCs) in immunotherapy. However, difficulty in acquiring these cells and possible ethical issues limited their application. Recently, we have isolated a unique MSC population from dental follicles with potent stem cell-like properties. Read More

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December 2018

Polymer spreading on substrates with nanoscale grooves using molecular dynamics.

Nanotechnology 2018 Dec 11. Epub 2018 Dec 11.

University of Utah, Salt Lake City, Utah, UNITED STATES.

Understanding how liquid polymer interacts with and spreads on surfaces with nanoscale texture features is crucial for designing complex nanoscale systems. We use molecular dynamics to simulate different types of polymer as they spread on substrates with a single nanoscale groove. We study how groove design affects the potential energy of a substrate and how this governs polymer spreading and orientation. Read More

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December 2018

Conformational and solution dynamics of hemoglobin (Hb) in presence of a cleavable gemini surfactant: Insights from spectroscopy, atomic force microscopy, molecular docking and density functional theory.

J Colloid Interface Sci 2018 Dec 3;538:489-498. Epub 2018 Dec 3.

Department of Chemistry, Arba Minch University, Ethiopia.

Herein, we have explored the conformational alterations of hemoglobin (Hb) in presence of a cleavable gemini surfactant (C16-C4O2-C16). The concerned surfactant was found to induce significant structural perturbations in Hb. UV-vis spectroscopy, steady-state/time-resolved fluorescence, and other utilized techniques have authenticated the complexation of Hb with the gemini surfactant. Read More

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December 2018

Superior activity of Pd nanoparticles confined in carbon nanotubes for hydrogen production from formic acid decomposition at ambient temperature.

J Colloid Interface Sci 2018 Dec 4;538:474-480. Epub 2018 Dec 4.

College of Chemistry and Environmental Protection Engineering, Southwest Minzu University, Chengdu 610041, Sichuan, China. Electronic address:

Designing highly efficient and low-cost catalysts is essential toward realizing the practical application of hydrogen generation by formic acid decomposition (FAD) under ambient conditions. Herein, we report the synthesis of a hybrid material of Pd nanoparticles encapsulated within carbon nanotubes (CNTs) (Pd-CNTs-in). Transmission electron microscopy images show that most Pd nanoparticles (mean diameter 4. Read More

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December 2018

Insight into photocatalytic activity, universality and mechanism of copper/chlorine surface dual-doped graphitic carbon nitride for degrading various organic pollutants in water.

J Colloid Interface Sci 2018 Dec 3;538:462-473. Epub 2018 Dec 3.

Institute of Green Chemistry and Chemical Technology, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China. Electronic address:

It is still a challenging work to realize the universality of photocatalytic materials for unselective removing various organic pollutants in water. Here a surface dual-doped Cu/Cl-g-CN photocatalyst is firstly prepared, which exhibits much more superior photocatalytic performance for degrading multifarious persistent organic pollutants including tetracycline hydrochloride (TC-HCl), o-chlorophenol, bisphenol A and 2-mercaptobenzothiazole in water than pure g-CN. The high-efficiency and unselective photocatalytic degradation performance derives from the surface dual-doped effect of Cu/Cl elements on g-CN, which results in the extended visible light harvest range, elevated CB potential and improved the separation efficiency of charge carriers. Read More

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December 2018

Measuring the water content in freshly-deposited fingermarks.

Forensic Sci Int 2018 Nov 26;294:204-210. Epub 2018 Nov 26.

Institute of Chemistry, The Hebrew University, Jerusalem, Israel. Electronic address:

The literature view regarding the composition of deposited fingermarks has long been that the average water content is in the range of 98-99wt.%. This value has recently been challenged by Kent, claiming that it should be 20wt. Read More

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November 2018
2 Reads

Molecular docking, molecular dynamics simulations and QSAR studies on some of 2-arylethenylquinoline derivatives for inhibition of Alzheimer's amyloid-beta aggregation: Insight into mechanism of interactions and parameters for design of new inhibitors.

J Mol Graph Model 2018 Dec 4;87:129-143. Epub 2018 Dec 4.

Chemistry Department, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran. Electronic address:

Alzheimer's disease is characterized using amyloid-beta (Aβ) aggregation. The present work was carried out to extend and design a novel quantitative structure-activity relationship (QSAR) model on inhibition efficiency of some of new 2-arylethenylquinoline derivatives against the Aβ peptide aggregation. The QSAR study, molecular docking and molecular dynamics (MD) simulations were performed to explore the influence of the structural features and investigate the molecular mechanism of ligands interactions with the Aβ peptide. Read More

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December 2018

A multifunctional sensor for selective and sensitive detection of vitamin B12 and tartrazine by Förster resonance energy transfer.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Dec 4;211:178-188. Epub 2018 Dec 4.

Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, China West Normal University, Nanchong 637002, China; Institute of Applied Chemistry, China West Normal University, Nanchong 637002, China. Electronic address:

We used thiamine nitrate (TN) as single material to fabricate nitrogen and sulfur co-doped carbon quantum dots (N,S-CQDs) with a quantum yield of 10.4% through one-pot hydrothermal method, and its properties were characterized by TEM, XPS, FTIR, fluorescence (FL) and UV-vis spectrophotometer, respectively. The fluorescence of N,S-CQDs was effectively quenched in the presence of vitamin B12 (VB12)/tartrazine due to Förster resonance energy transfer (FRET). Read More

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December 2018

Measurements and correlations in solution-state for charge transfer products caused from the 1:2 complexation of TCNE acceptor with several important drugs.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Dec 5;211:166-177. Epub 2018 Dec 5.

Department of Chemistry, Faculty of Science, Taif University, Al-Haweiah, P.O. Box 888, 21974 Taif, Saudi Arabia; Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.

In our previous work, we highlighted the thermodynamic and spectroscopic characteristics of the 1:1 charge transfer (CT) complexation of TCNE acceptor with various medically important drugs. Continuing that work, we further examine drugs that react with the TCNE acceptor via a 1:2 interaction. The examined drugs are atenolol, quinidine, cimetidine, reserpine, and levofloxacin. Read More

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December 2018

In vitro profiling of volatile organic compounds released by Simpson-Golabi-Behmel syndrome adipocytes.

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Nov 28;1104:256-261. Epub 2018 Nov 28.

Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Carinagasse 47, A-6800 Feldkirch, Austria; Private University of the Principality of Liechtenstein, Triesen, Liechtenstein; Medical Central Laboratories, A-6800 Feldkirch, Austria.

Breath analysis offers a non-invasive and rapid diagnostic method for detecting various volatile organic compounds that could be indicators for different diseases, particularly metabolic disorders including type 2 diabetes mellitus. The development of type 2 diabetes mellitus is closely linked to metabolic dysfunction of adipose tissue and adipocytes. However, the VOC profile of human adipocytes has not yet been investigated. Read More

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November 2018

A novel MUC1 aptamer-modified PLGA-epirubicin-PβAE-antimir-21 nanocomplex platform for targeted co-delivery of anticancer agents in vitro and in vivo.

Colloids Surf B Biointerfaces 2018 Dec 4;175:231-238. Epub 2018 Dec 4.

Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Conventional chemotherapy suffers from several drawbacks, including toxic side effects together with the development of resistance to the chemical agents. Therefore, exploring alternative therapeutic approaches as well as developing targeted delivery systems are in demand. Oligonucleotide-based therapy has emerged as a promising and alternative procedure for treating malignancies involving gene-related diseases. Read More

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December 2018

A semi-mechanistic model describing the influence of light and temperature on the respiration and photosynthetic growth of Chlorella vulgaris.

Bioresour Technol 2018 Nov 29;274:361-370. Epub 2018 Nov 29.

Laboratory for Industrial Water and Ecotechnology (LIWET), Department of Green Chemistry and Technology, Ghent University Campus Kortrijk, Graaf Karel de Goedelaan 5, B-8500 Kortrijk, Belgium.

The influence of light and temperature on microalgae kinetics has been assessed extensively and many models have been developed. However, limited attention has been paid to the influence of light and temperature on microalgae respiration and growth under conditions inducing (strong) photoinhibition and no clear consensus has been made on which model to use. Based on experimental data collected using a combined respirometer-titrimeter, a previously developed microalgae model (Decostere et al. Read More

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November 2018

Engineering of multiple modular pathways for high-yield production of 5-aminolevulinic acid in Escherichia coli.

Bioresour Technol 2018 Dec 3;274:353-360. Epub 2018 Dec 3.

The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China; The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, China. Electronic address:

5-aminolevulinic acid (ALA), an important precursor of tetrapyrroles, has various applications in medicine and agriculture fields. Several methods have been adopted to enhance ALA synthesis in our previous studies. In this study, systematic metabolic engineering strategies were implemented to further improve ALA production in Escherichia coli. Read More

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December 2018

Diabetes-induced neuropathic mechanical hyperalgesia depends on P2X4 receptor activation in Dorsal Root Ganglia.

Neuroscience 2018 Dec 8. Epub 2018 Dec 8.

Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), Campinas, SP, Brazil. Electronic address:

Peripheral diabetic neuropathy (PDN) manifests in 50-60% of type I and II diabetic patients and is the major cause of limb amputation. Adequate therapy for PDN is a current challenge. There are evidences that the activation of the P2X4 receptor (P2X4R) expressed on microglial cells of the central nervous system takes part in the development of neuropathic pain. Read More

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December 2018
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BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines.

Cancer Cell 2018 Dec;34(6):879-891

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia. Electronic address:

Defects in apoptotic cell death can promote cancer and impair responses of malignant cells to anti-cancer therapy. Pro-survival BCL-2 proteins prevent apoptosis by keeping the cell death effectors, BAX and BAK, in check. The BH3-only proteins initiate apoptosis by neutralizing the pro-survival BCL-2 proteins. Read More

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December 2018

Sol gel synthesis of hybrid chitosan/calcium aluminosilicate nanocomposite membranes and its application as support for CO sensor.

Int J Biol Macromol 2018 Dec 8. Epub 2018 Dec 8.

Inorganic Chemistry Department, National Research Centre, El-Buhouth St., Dokki, Giza 12622, Egypt; Packaging Materials Department, National Research Centre, El-Bohouth St., Dokki, Giza 12622, Egypt. Electronic address:

Modification of chitosan with cross-linkers, blends with various kinds of polymers, nanoparticles and new organic-inorganic hybrid composites in order to obtain some improved properties attached more attention nowadays due to their good sensitivity in changing electrical and optical properties. In the current work modified hybrid chitosan/calcium aluminosilicate (CH/CAS) nanocomposite membranes and doped with (3, 5 & 7 mol%) AlO nanoparticles were synthesized via sol-gel process in acidic conditions, which can be efficiently employed to capture CO gas at lower and moderate temperatures. Furthermore, the fabricated CH/CAS nanocomposite membrane loading with (3, 5 & 7 mol%) AlO were investigated using XRD, SEM, FTIR and dielectric measurements. Read More

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December 2018

Chemotherapy sensitization of glioblastoma by focused ultrasound-mediated delivery of therapeutic liposomes.

J Control Release 2018 Dec 8. Epub 2018 Dec 8.

Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1-5, 8093 Zurich, Switzerland.

In glioblastoma, the benefit from temozolomide chemotherapy is largely limited to a subgroup of patients (30-35%) with tumors exhibiting methylation of the promoter region of the O-methylguanine-DNA methyltransferase (MGMT) gene. In order to allow more patients to benefit from this treatment, we explored magnetic resonance image-guided microbubble-enhanced low-intensity pulsed focused ultrasound (LIFU) to transiently open the blood-brain barrier and deliver a first-in-class liposome-loaded small molecule MGMT inactivator in mice bearing temozolomide-resistant gliomas. We demonstrate that a liposomal O-(4-bromothenyl)guanine (OBTG) derivative can efficiently target MGMT, thereby sensitizing murine and human glioma cells to temozolomide in vitro. Read More

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December 2018

Further Evidence Regarding the Important Role of Chlorine Atoms of Aripiprazole on Binding to the Site II Area of Human Albumin.

J Pharm Sci 2018 Dec 8. Epub 2018 Dec 8.

Faculty of Pharmaceutical Sciences, Sojo University; DDS Research Institute, Ikeda 4-22-Nishi-ku, Kumamoto 860-0082, Japan. Electronic address:

Previously, we reported on the high affinity binding of aripiprazole (ARP), an antipsychotic drug, to human albumin and the role of the chlorine atom of ARP on this binding. In this study, we investigated the binding mode of ARP to human albumin in detail using ARP derivatives and several animal-derived albumins. ARP bound strongly to human and dog albumin. Read More

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December 2018

The pK values of the catalytic residues in the retaining glycoside hydrolase T26H mutant of T4 lysozyme.

Protein Sci 2018 Dec 7. Epub 2018 Dec 7.

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada, V6T 1Z3.

T4 phage lysozyme (T4L) is an enzyme that cleaves bacterial cell wall peptidoglycan. Remarkably, the single substitution of the active site Thr26 to a His (T26H) converts T4L from an inverting to a retaining glycoside hydrolase with transglycosylase activity. It has been proposed that T26H-T4L follows a double displacement mechanism with His26 serving as a nucleophile to form a covalent glycosyl-enzyme intermediate (Kuroki et al. Read More

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December 2018
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High Performance Thermally Activated Delayed Fluorescence Sensitized Organic Light-Emitting Diodes.

Chem Rec 2018 Dec 10. Epub 2018 Dec 10.

Key Lab of Organic Optoelectronics and Molecular Engineering of Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, China.

Recently, organic light-emitting diodes (OLEDs) employing thermally activated delayed fluorescence (TADF) materials have aroused huge attention in both academia and industry. Compared with fluorescent and phosphorescent materials, TADF materials can theoretically capture 100 % excitons without incorporating noble metals, making them effective emitters and hosts for OLEDs simultaneously. Here, in this review, our recent works on mechanisms and materials of high performance TADF-sensitized phosphorescent (TSP) OLEDs, TADF-sensitized fluorescent (TSF) OLEDs and TADF-sensitized TADF (TST) OLEDs are summarized. Read More

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December 2018

Synthesis of Negative-Charged Metal-Containing Cyclomatrix Polyphosphazene Microspheres Based on Polyoxometalates and Application in Charge-Selective Dye Adsorption.

Macromol Rapid Commun 2018 Dec 7:e1800730. Epub 2018 Dec 7.

Department of Applied Chemistry, School of Science MOE Key Lab for Materials Physics and Chemistry Extraordinary Condition, Northwestern Polytechnical University, Xi'an 710129, Shaanxi, China.

A negative-charged, metal-containing cyclomatrix polyphosphazene microsphere (MCPM) is synthesized using the strategy of precipitation polymerization of di-functionalized polyoxometalates (POMs) and hexachlorocyclotriphosphazene. The chemical structure of these MCPMs is well characterized by C MAS NMR and P MAS NMR, as well as FT-IR, electron microscopy, and X-ray photoelectron spectroscopy. The covalent grafting of the rigid POMs clusters into the framework of these microspheres prevents the collapsing of the pores, making these MCPMs porous materials. Read More

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December 2018

Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation.

Aging Cell 2018 Dec 10:e12845. Epub 2018 Dec 10.

Department of Cell Biology and Biophysics, Faculty of Biology, National & Kapodistrian University of Athens, Athens, Greece.

Metazoans viability depends on their ability to regulate metabolic processes and also to respond to harmful challenges by mounting anti-stress responses; these adaptations were fundamental forces during evolution. Central to anti-stress responses are a number of short-lived transcription factors that by functioning as stress sensors mobilize genomic responses aiming to eliminate stressors. We show here that increased expression of nuclear factor erythroid 2-related factor (Nrf2) in Drosophila activated cytoprotective modules and enhanced stress tolerance. Read More

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December 2018

Cobalt-Catalyzed Hiyama-type C-H Activation with Arylsiloxanes: Versatile Access to Highly-Ortho-Decorated Biaryls.

Chemistry 2018 Dec 11. Epub 2018 Dec 11.

Georg-August-Universitaet Goettingen, Institut fuer Organische und Biomolekulare Chemie, Tammannstr. 2, 37077, Goettingen, GERMANY.

Versatile direct Hiyama-type C-H arylations of benzamides were accomplished with organosiloxanes by chelation- assisted cobalt catalysis. The C-H arylation featured broad substrate scope, including challenging C(sp3)-H activation, the use of GVL as biomass-derived solvent, and selectively provided the desired biaryls, even when being highly sterically hindered. Read More

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December 2018

Borylated N-heterocyclic carbenes: rearrangement and chemical trapping.

Chemistry 2018 Dec 11. Epub 2018 Dec 11.

UNITED KINGDOM.

This study details attempts to access N-heterocyclic carbenes (NHCs) featuring the diazaborolyl group, {(HCNDipp)2B}, as one or both of the N-bound substituents. Attempts to isolate N-heterocyclic carbenes based around imidazolylidene or related heterocycles, are characterized by facile N-to-C migration of the boryl substituent. In the cases of imidazolium precursors bearing one N-bound diazaboryl group and one methyl substituent, deprotonation leads to the generation of the target carbenes, which can be characterized in situ by NMR measurements, and trapped by reactions with metal fragments and elemental selenium. Read More

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December 2018

Physical Chemistry in all its Diversity.

Chemphyschem 2018 Dec 11. Epub 2018 Dec 11.

Wiley-VCH Verlag GmbH & Co. KGaA, ChemPhysChem, Boschstrasse 12, 69469, Weinheim, Germany.

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December 2018

Round-the-clock Photocatalytic Hydrogen Production with High Efficiency by a Long Afterglow Material.

Angew Chem Int Ed Engl 2018 Dec 7. Epub 2018 Dec 7.

Shandong Normal University, No.88 Wenhua East Road, Jinan, CHINA.

Long afterglow materials can store and release light energy after illumination. Here, a brick-like, micron-sized Sr2MgSi2O7:Eu2+,Dy3+ long afterglow material is used for hydrogen production via the photocatalytic reforming of methanol under round-the-clock conditions for the first time, achieving a solar-to-hydrogen (STH) conversion efficiency of 5.18%. Read More

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December 2018

Spontaneous Symmetry Breaking in the Formation of Supramolecular Polymers: Implications for the Origin of Biological Homochirality.

Angew Chem Int Ed Engl 2018 Dec 9. Epub 2018 Dec 9.

Georgia Tech, UNITED STATES.

Aqueous solutions of the achiral, monomeric, nucleobase mimics triaminopyrimidine (TAP) and a cyanuric acid derivative (CyCo6) spontaneously assemble into macroscopic homochiral domains of supramolecular polymers. These assemblies exhibit a high degree of chiral amplification. Addition of a small quantity of one handedness of a chiral derivative of CyCo6 generates exclusively homochiral structures. Read More

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December 2018

Protein-Bound Freestanding 2D Metal Film for Stealth Information Transmission.

Adv Mater 2018 Dec 9:e1803377. Epub 2018 Dec 9.

Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710119, China.

The welding and sintering of nanomaterials is usually achieved at high temperatures and high pressures. Here, it is found that merging of metal nanoparticles occurs under ambient conditions in an aqueous solution via protein bonding. It is discovered that the silver nanoparticles from the in situ reduction of silver ammonium ions by glucose undergo confined nucleation and growth and are bound by ultrathin amyloid-like β-sheet stacking of lysozyme. Read More

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December 2018

Mo-based Oxidizers as Powerful Tools for the Synthesis of Thia- and Selenaheterocycles.

Chemistry 2018 Dec 7. Epub 2018 Dec 7.

GERMANY.

: A highly efficient synthetic protocol for the synthesis of thia- and selenaheterocycles has been developed. By employing MoCl5-mediated intramolecular dehydrogenative coupling reaction, a broad variety of structural motifs was isolated in yields up to 94%. The electrophilic key transformation is tolerated by several labile moieties like halides and tertiary alkyl groups. Read More

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December 2018

Correspondence on "Preorganization and Cooperation for Highly Efficient and Reversible Capture of Low-Concentration CO by Ionic Liquids".

Angew Chem Int Ed Engl 2018 Dec 11. Epub 2018 Dec 11.

Institute of Chemistry-, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9500, Porto Alegre, 91501-970, RS, Brazil.

The preorganization and cooperation mechanism of imide-based ionic liquids reported in a recent Communication was evocated to rationalize the extremely high gravimetric CO capture displayed by these fluids. An analysis of the reported spectroscopic evidences together with additional experiments led to the proposition of an alternative, simpler, and feasible mechanism involving the formation of bicarbonate. Read More

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December 2018

Living 3,4-(Co)Polymerization of Isoprene/Myrcene and One-Pot Synthesis of Polyisoprene Blend Catalyzed by Binuclear Rare Earth Complexes Bearing the Bridged Amidinate Ligand.

Chemistry 2018 Dec 7. Epub 2018 Dec 7.

Fudan University, Department of Chemistry, No.2005 Songhu Road, Yangpu District,, 200438, Shanghai, CHINA.

Mononuclear amidinate yttrium complex C₄H₉C(NR)₂Y(o-CH₂C₆H₄NMe₂)₂ (R = 2,6-iPr₂C₆H₃) and a series of binuclear rare-earth-metal complexes bearing a bridged amidinate ligand [(RN)₂C(CH₂)₄C(NR)₂][Ln(CH₂C₆H₄(o-NMe₂))₂]₂(R = 2,6-iPr₂C₆H₃, Ln = Y, Lu, Sc) were synthesized and fully characterized. The catalytic behavior of these complexes for (co)polymerization of conjugated dienes such as isoprene and myrcene in the presence of cocatalyst [Ph₃C][B(C₆F₅)₄] was investigated. These catalytic systems show impressive high activity and 3,4 regio-selectivity in livingness fashion. Read More

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December 2018

Synthetic Methodology for Structurally defined and Unidirectional Insulated Molecular Wires via Iterative Intramolecular Slippage.

Chem Asian J 2018 Dec 7. Epub 2018 Dec 7.

Osaka Dental University, JAPAN.

Unidirectional insulated molecular wires (IMWs) were precisely synthesized via iterative cross-coupling reactions in organic solvents and subsequent intramolecular slippage transformation in aqueous solvents. This programmable synthetic procedure selectively afforded both insulated and uninsulated molecular wires bearing oligo (phenylene ethynylene) and permethylated α-cyclodextrins with well-defined conjugation lengths and supramolecular structures. High selectivity of this method was confirmed by NMR and mass spectroscopic analyses. Read More

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December 2018

Reactions in Water-A Greener Approach Using Ruthenium Catalysts.

Chem Rec 2018 Dec 7. Epub 2018 Dec 7.

Polymers and Functional Materials Division, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad, 500007.

Reactions using transition metals as catalysts have emerged as an efficient method in the recent times. However, the selection of solvent plays a crucial role in this regard. Several solvents used traditionally suffer majorly with problems of toxicity; high boiling point etc. Read More

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December 2018

A Self-Pumping Dressing for Draining Excessive Biofluid around Wounds.

Adv Mater 2018 Dec 9:e1804187. Epub 2018 Dec 9.

CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, CAS Center for Excellence in Nanoscience, Technical Institute of Physics and Chemistry, University of Chinese Academy of Sciences, Beijing, 100190, P. R. China.

Excessive biofluid around wounds often causes infection and hinders wound healing. However, the intrinsic hydrophilicity of the conventional dressing inevitably retains excessive biofluid at the interface between the dressing and the wound. Herein, a self-pumping dressing is reported, by electrospinning a hydrophobic nanofiber array onto a hydrophilic microfiber network, which can unidirectionally drain excessive biofluid away from wounds and finally accelerate the wound healing process. Read More

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December 2018

Anti-proliferative and anti-malarial activities of spiroisoxazoline analogues of artemisinin.

Arch Pharm (Weinheim) 2018 Dec 10:e1800192. Epub 2018 Dec 10.

Department of Chemistry, School of Chemical and Life Science, Jamia Hamdard, New Delhi, India.

A series of spiroisoxazoline analogues of artemisinin was synthesized by employing 1,3-dipolar cycloaddition between various in situ generated nitrile oxides and artemisitene. All the synthesized compounds were tested for their anti-proliferative and anti-malarial activities. Among the compounds tested, compound 11a was found to be potent against the HCT-15 cancer cell line with IC  = 4. Read More

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December 2018
1 Read

Activity and pharmacology of homemade silver nanoparticles in refractory metastatic head and neck squamous cell cancer.

Head Neck 2018 Dec 11. Epub 2018 Dec 11.

Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas.

Background: Silver nanoparticles (AgNP) show efficacy in cancer cell lines. We present the first in-human outcome of AgNP in a cancer patient.

Methods: Homemade AgNP solution is manufactured using online instructions by a 78-year old male. Read More

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December 2018

Reduction of carbon oxides by an acyclic silylene: reductive coupling of CO.

Angew Chem Int Ed Engl 2018 Dec 7. Epub 2018 Dec 7.

University of Oxford, Chemistry, Inorganic Chemistry Laboratory, South Parks Road, SN77RR, Oxford, UNITED KINGDOM.

The reactions of a boryl-substituted acyclic silylene with carbon dioxide and monoxide are reported. The former proceeds via oxygen atom abstraction, generating CO (with rearrangement of the putative silanone product via silyl group transfer). The latter is characterized by reductive coupling of CO to give an ethynediolate fragment which inserts into the Si-B bond. Read More

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December 2018

A versatile synthetic route to the preparation of N heterocycles.

J Labelled Comp Radiopharm 2018 Dec 11. Epub 2018 Dec 11.

International Tomography Center SB RAS, Novosibirsk, Russia.

A robust medium-scale (~3 g) synthetic method for N labeling of pyridine ( N-Py) is reported based on the Zincke reaction. N enrichment in excess of 81% was achieved with ~33% yield. N-Py serves as a standard substrate in a wide range of studies employing a hyperpolarization technique for efficient polarization transfer from parahydrogen to heteronuclei; this technique, called SABRE (Signal Amplification by Reversible Exchange), employs a simultaneous chemical exchange of parahydrogen and to-be-hyperpolarized substrate (e. Read More

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December 2018
1 Read

Spectrofluorimetric determination of eptifibatide in human plasma and dosage form.

Luminescence 2018 Dec 11. Epub 2018 Dec 11.

Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El- Aini Street, Cairo, Egypt.

A spectrofluorimetric method for the determination of eptifibatide is presented based on its native fluorescence. The type of solvent and the wavelength of maximum excitation and emission were carefully selected to optimize the experimental conditions. Under the specified experimental conditions, the linearities obtained between the emission intensity and the corresponding concentrations of eptifibatide were in the range 0. Read More

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December 2018
1 Read

A New Drug Delivery System based on Tauroursodeoxycholic Acid and PEDOT.

Chemistry 2018 Dec 11. Epub 2018 Dec 11.

ITALY.

Localized drug delivery represents one of the most challenging uses of systems based on conductive polymer films. Typically, anionic drugs are incorporated within conductive polymers through the electrostatic interaction with the positively charged polymer. Following this approach, the synthetic glucocorticoid Dexamethasone-phosphate is often delivered from neural probes to reduce the inflammation of the surrounding tissue. Read More

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December 2018

YHp as a highly stable, hyper-copy, hyper-expression plasmid constructed using a full 2 μm circle sequence in cir0 strains of Saccharomyces cerevisiae.

Yeast 2018 Dec 7. Epub 2018 Dec 7.

Department of Applied Chemistry, Graduate School of Sciences and Technology for Innovation, Yamaguchi University, Ube, 755-8611, Japan.

In the yeast Saccharomyces cerevisiae, the plasmid YEp, containing a partial sequence from a natural 2 μm plasmid, has been frequently used to induce high levels of gene expression. In this study, we used Japanese sake yeast natural cir0 strain as a host for constructing an entire 2 μm plasmid with an expression construct using the three-fragment gap-repair method without Escherichia coli manipulation. The 2 μm plasmid contains two long inverted repeats, which is problematic for PCR amplification. Read More

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December 2018

A High Lignin Content Removable and Glycol-Assisted Repairable Coating Based on Dynamic Covalent Bonds.

ChemSusChem 2018 Dec 10. Epub 2018 Dec 10.

Washington State University, School of Mechanical and Materials Engineering, Composite Materials and Engineering Center, Pullman, UNITED STATES.

Conventional thermoset coating cannot be easily repaired and removed due to their highly crosslinked structure. The investigation of repairable or removable coating has been receiving extensive attentions, but few reported coatings possess both features. In this work, a repairable and removable coating is developed through the curing of a modified Kraft lignin (L-COOH) with poly (ethylene glycol) diglycidyl ether (PEG-epoxy) in the presence of zinc catalyst. Read More

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December 2018

Palladium-Catalyzed Intermolecular [4+1] Spiroannulation via C(sp3)-H Activation and Naphthol Dearomatization.

Angew Chem Int Ed Engl 2018 Dec 10. Epub 2018 Dec 10.

Northwest University, college of chemistry & materials science, 1 Xuefu Ave, Changan District, 710127, Xi'an, CHINA.

A novel palladium-catalyzed [4+1] spiroannulation was developed by using a C(sp3)-H activation/naphthol dearomatization approach. This bimolecular domino reaction of two aryl halides was realized through a sequence of cyclometallation-facilitated C(sp3)-H activation, biaryl cross-coupling, and naphthol dearomatization, thus rendering the rapid assembly of a new class of spirocyclic molecules in good yields with broad functional group tolerance. Preliminary mechanistic studies indicated that C-H cleavage is likely involved in the rate-determining step, and the five-membered palladacycle was identified as the key intermediate for the intermolecular coupling. Read More

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December 2018

A small cyclic β-hairpin peptide mimics of the Rbfox2 RRM that binds to the precursor miRNA 20b.

Chembiochem 2018 Dec 11. Epub 2018 Dec 11.

UNITED STATES.

The RRM (RNA-recognition motif), the most abundant RNA-binding motif in eukaryotes, is a small folded domain of about 90 amino acids, yet the β2-β3 hairpin corresponding to strands 2 and 3 of the β-sheet, and the intervening loop makes essential interactions with RNA in many RRM complexes. We designed a series of small cyclic peptides mimics of the β2-β3 hairpin of Rbfox2 protein, that recognize the terminal loop of precursor miR-20b, to investigate whether it is possible to mimic the full RNA-binding protein with a minimal structurally pre-organized peptide. Within a small library of 7 cyclic peptides, we identify a peptide with low µ-molar affinity for the miR-20b precursor. Read More

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December 2018
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Detection of NO Down to One ppb Using Ion-in-Conjugation-Inspired Polymer.

Small 2018 Dec 7:e1803896. Epub 2018 Dec 7.

College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, P. R. China.

Nitrogen dioxide (NO ) emission has severe impact on human health and the ecological environment and effective monitoring of NO requires the detection limit (limit of detection) of several parts-per-billion (ppb). All organic semiconductor-based NO sensors fail to reach such a level. In this work, using an ion-in-conjugation inspired-polymer (poly(3,3'-diaminobenzidine-squarine, noted as PDBS) as the sensory material, NO can be detected as low as 1 ppb, which is the lowest among all reported organic NO sensors. Read More

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December 2018

Selective Primary Oxidation of Lignin Streams from Butanol-Pretreated Agricultural Waste Biomass.

ChemSusChem 2018 Dec 10. Epub 2018 Dec 10.

University of St Andrews, School of Chemistry, North Haugh, KY16 9ST, St Andrews, UNITED KINGDOM.

Chemically modified lignins are important for the generation of biomass-derived materials and as precursors to renewable aromatic monomers. A butanol-based organosolv pretreatment has been used to convert an abundant agricultural waste product, rice husks, into a cellulose pulp and three additional product streams. One of these streams, a butanol-modified lignin, was oxidised at the γ-position to give a carboxylic acid functionalized material. Read More

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December 2018

A multi-step virtual screening protocol for identification of novel non-acidic microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors.

ChemMedChem 2018 Dec 11. Epub 2018 Dec 11.

Gazi Universitesi Eczacilik Fakultesi, Pharmaceutical Chemistry, Tac Sokak No 3, 06580, Ankara, TURKEY.

Microsomal prostaglandin E2 synthase-1 (mPGES-1) is considered as potential therapeutic target for treatment of inflammatory diseases and certain types of cancer. In order to capture novel scaffolds for mPGES-1 inhibition, we applied a virtual screening protocol comprising molecular docking, fingerprints-based clustering with diversity-based selection, protein-ligand interactions fingerprints, and molecular dynamics (MD) simulations with Molecular Mechanic-Poisson Boltzmann Surface Area (MM-PBSA) calculation. The hits identified were carefully analyzed to ensure the selection of novel scaffolds, which make stable interactions with key residues in the mPGES-1 binding pocket and inhibit the catalytic activity of the enzyme. Read More

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December 2018

Structural analysis of the inhibitory effects of polyphenols, (+)-hopeaphenol and (-)-isohopeaphenol, on human SIRT1.

Biofactors 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Analytical Neurobiology, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku, Nagoya, Japan.

Human sirtuin 1 (hSIRT1) is a NAD -dependent deacetylase that regulates several cellular processes. Unlike resveratrol, natural polymeric phenolic compounds isolated from Vitaceae are mostly hSIRT1 inhibitors. The resveratrol tetramer, (+)-hopeaphenol ((+)-HP), and its geometric isomer, (-)-isohopeaphenol ((-)-iHP), were tested for inhibitory effects on purified hSIRT1 using a fluorescent derivative of peptide substrate p53-AMC (Fluor de Lys) and a cofactor NAD . Read More

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December 2018

Stabilizing RbPbBr3 Perovskite Nanocrystals through Cs+ Substitution.

Chemistry 2018 Dec 10. Epub 2018 Dec 10.

Beijing Institute of Technology, 100081, Beijing, CHINA.

The ABX3-type halide perovskite nanocrystals (NCs) have been a hot topic recently due to their fascinating optoelectronic properties. It has been demonstrated that A-site ion has an impact on the photophysical and chemical properties, such as optical bandgap and chemical stability. The pursuit of halide perovskite materials with diversified A-site species would deepen the understanding on the structure-property relationship of the perovskite family. Read More

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December 2018

A nanostructured Si/SiOC composite anode with volume-change-buffering microstructure for lithium ion batteries.

Chemistry 2018 Dec 7. Epub 2018 Dec 7.

Harbin Institute of Technology, School of Chemical Engineering and Technology, No.92 West Da Zhi Street, 150001, Harbin, CHINA.

Si/SiOC composites are promising high-capacity anode materials of lithium ion batteries since SiOC matrix can buffer effectively the volumetric change of Si during cycling. However, the structure of Si nanoparticles enwrapped by continuous SiOC phase shows typically poor cyclic stability and low charge/discharge rate due to the structure failure of bulk SiOC shell that derived from carbon-rich organosilicon. In this instance, a Si/SiOC nanocomposite with volume-change-buffering microstructure, where Si nanoparticles disperse uniformly in SiOC nanospheres matrix, is synthesized. Read More

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December 2018
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