7,406 results match your criteria Chemico-biological interactions[Journal]


Development of Caco-2 cells-based gene reporter assays and evaluation of herb-drug interactions involving CYP3A4 and CYP2D6 gene expression.

Chem Biol Interact 2019 Feb 14. Epub 2019 Feb 14.

Programa de Pós-Graduação Em Farmácia, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil. Electronic address:

The indiscriminate use of medicinal plants and herbal medicinal products concomitantly with conventional drugs may result in herb-drug interactions that may lead to fluctuations in drug bioavailability, therapeutic failure, and/or toxic effects. CYP450 enzymes play an important role in drug biotransformation and herb-drug interactions. Thus, the aim of this study was to develop and apply Caco-2 cells-based gene reporter assays to study in vitro the potential occurrence of CYP3A4 and CYP2D6 gene expression modulation by standardized extracts of selected medicinal plants. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.030DOI Listing
February 2019

Oxidation of imidazole- and pyrazole-derived aldehydes by plant aldehyde dehydrogenases from the family 2 and 10.

Chem Biol Interact 2019 Feb 12. Epub 2019 Feb 12.

Department of Protein Biochemistry and Proteomics, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science, Palacký University, Šlechtitelů 27, 783 71, Olomouc, Czech Republic. Electronic address:

Plant cytosolic aldehyde dehydrogenases from family 2 (ALDH2s, EC 1.2.1. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.02.008DOI Listing
February 2019

Chlortetracycline and melanin biopolymer - The risk of accumulation and implications for phototoxicity: An in vitro study on normal human melanocytes.

Chem Biol Interact 2019 Feb 12. Epub 2019 Feb 12.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Silesia, Jagiellońska 4, PL 41-200, Sosnowiec, Poland.

Tetracyclines belong to antimicrobial classes with the highest consumption in veterinary medicine and agriculture, which leads to the contamination of the environment and food products, as well as to antibiotic resistance and adverse drug reactions. Chloro-derivatives of tetracyclines are thought to be relatively more phototoxic than others and belong to the most frequently cited drugs as photosensitizers. Melanins are heterogenous biopolymers determining skin, hair and eye colour. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.02.005DOI Listing
February 2019

Ionizing radiations epidemiology does not support the LNT model.

Chem Biol Interact 2019 Feb 11. Epub 2019 Feb 11.

Northern Ontario School of Medicine, Sudbury, Ontario, Canada.

Most cancers are multifactorial diseases. Yet, epidemiological modeling of the effect of ionizing radiation (IR) exposures based on the linear no-threshold model at low doses (LNT) has generally not included co-exposure to chemicals, dietary, socio-economic and other risk factors also known to cause the cancers imputed to IR. When so, increased cancer incidences are incorrectly predicted by being solely associated with IR exposures. Read More

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http://dx.doi.org/10.1016/j.cbi.2018.11.014DOI Listing
February 2019

Economic benefit-cost implications of the LNT model.

Chem Biol Interact 2019 Feb 11. Epub 2019 Feb 11.

The Mercatus Center at George Mason University, 3434 Washington Boulevard, 4th Floor, Arlington VA, 22201, United States; The Center for Growth and Oppportunity Utah State University, 3525 Old Main Hill Logan, UT, 84322-3525, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2019.01.028DOI Listing
February 2019

Dedication and prologue.

Authors:
Robert Golden

Chem Biol Interact 2019 Feb 11. Epub 2019 Feb 11.

ToxLogic, 702 Linslade St, Gaithersburg, MD, 20878, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2019.01.007DOI Listing
February 2019

The LNT model for cancer induction is not supported by radiobiological data.

Chem Biol Interact 2019 Feb 11. Epub 2019 Feb 11.

Northern Ontario School of Medicine, Laurentian University, 935 Ramsey Lake Rd, Sudbury, ON, P3E 2C6, Canada. Electronic address:

The hallmarks of cancer have been the focus of much research and have influenced the development of risk models for radiation-induced cancer. However, natural defenses against cancer, which constitute the hallmarks of cancer prevention, have largely been neglected in developing cancer risk models. These natural defenses are enhanced by low doses and dose rates of ionizing radiation, which has aided in the continuation of human life over many generations. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.013DOI Listing
February 2019

The impact of dose rate on the linear no threshold hypothesis.

Authors:
Antone L Brooks

Chem Biol Interact 2019 Feb 11. Epub 2019 Feb 11.

Environmental Science, Washington State University, Richland, WA, USA. Electronic address:

The goal of this manuscript is to define the role of dose rate and dose protraction on the induction of biological changes at all levels of biological organization. Both total dose and the time frame over which it is delivered are important as the body has great capacity to repair all types of biological damage. The importance of dose rate has been recognized almost from the time that radiation was discovered and has been included in radiation standards as a Dose, Dose Rate, Effectiveness Factor (DDREF) and a Dose Rate Effectiveness Factor (DREF). Read More

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http://dx.doi.org/10.1016/j.cbi.2018.12.007DOI Listing
February 2019

Dose-dependence of chemical carcinogenicity: Biological mechanisms for thresholds and implications for risk assessment.

Chem Biol Interact 2019 Feb 7. Epub 2019 Feb 7.

Ramboll US Corporation, Research Triangle Park, NC, USA.

Current regulatory practices for chemical carcinogens were established when scientific understanding of the molecular mechanisms of chemical carcinogenesis was in its infancy. Initial discovery that DNA mutation was the root of cancer led quickly to regulatory processes that assumed such a simple relationship could be described with a linear approach. This linear, no threshold approach has since become the default approach to risk assessment of chemicals with carcinogenic potential. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.025DOI Listing
February 2019

BEIR VI radon: The rest of the story.

Chem Biol Interact 2019 Feb 11. Epub 2019 Feb 11.

Environmental Science, Washington State University, Richland, WA, USA. Electronic address:

The National Academy of Sciences (USA) conducted an extensive review on the health effects of radon (BEIR VI). This was a well written and researched report which had impact on regulations, laws and remediation of radon in homes. There were a number of problems with the interpretation of the report and three are focused on here. Read More

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http://dx.doi.org/10.1016/j.cbi.2018.11.012DOI Listing
February 2019

Re-evaluation of the linear no-threshold (LNT) model using new paradigms and modern molecular studies.

Chem Biol Interact 2019 Feb 11. Epub 2019 Feb 11.

Northern Ontario School of Medicine, Laurentian University, 935 Ramsey Lake Rd, Sudbury, ON, P3E 2C6, Canada; Bruce Power, Tiverton, ON(3), UK. Electronic address:

The linear no-threshold (LNT) model is currently used to estimate low dose radiation (LDR) induced health risks. This model lacks safety thresholds and postulates that health risks caused by ionizing radiation is directly proportional to dose. Therefore even the smallest radiation dose has the potential to cause an increase in cancer risk. Read More

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http://dx.doi.org/10.1016/j.cbi.2018.11.013DOI Listing
February 2019

The linear No-Threshold (LNT) dose response model: A comprehensive assessment of its historical and scientific foundations.

Chem Biol Interact 2019 Feb 11. Epub 2019 Feb 11.

Department of Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA, 01003, USA. Electronic address:

The linear no-threshold (LNT) single-hit (SH) dose response model for cancer risk assessment is comprehensively assessed with respect to its historical foundations. This paper also examines how mistakes, ideological biases, and scientific misconduct by key scientists affected the acceptance, validity, and applications of the LNT model for cancer risk assessment. In addition, the analysis demonstrates that the LNT single-hit model was inappropriately adopted for governmental risk assessment, regulatory policy, practices, and for risk communication. Read More

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http://dx.doi.org/10.1016/j.cbi.2018.11.020DOI Listing
February 2019

Review of the evidence for thresholds for DNA-Reactive and epigenetic experimental chemical carcinogens.

Chem Biol Interact 2019 Feb 11. Epub 2019 Feb 11.

Department of Pathology, New York Medical College, Valhalla, NY, 10595, USA.

In the deliberations over many years on the question of thresholds for the carcinogenicity of chemicals, the dominant paradigm has been the linear no-threshold (LNT) model, derived from concepts formulated in radiation mutagenicity. Based on the analogy with radiation, the key mechanistic assumption underlying the assessment of the dose-effect of chemical-induced carcinogenicity has been that any dose, no matter how low, can lead to induction of mutations, which will result in some risk of neoplasia. The LNT assumption, however, was never well founded and, its application to chemical carcinogens, does not allow for differences in their disposition or mechanisms of action. Read More

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http://dx.doi.org/10.1016/j.cbi.2018.11.011DOI Listing
February 2019

Suppressive effects of pelargonidin on lipopolysaccharide-induced inflammatory responses.

Chem Biol Interact 2019 Feb 10;302:67-73. Epub 2019 Feb 10.

College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics Based Creative Drug Research Team, Kyungpook National University, Daegu, 41566, Republic of Korea. Electronic address:

Pelargonidin (PEL) is a well-known red pigment found in plants, and has been reported as having important biological activities that are potentially beneficial for human health. Here, we tested the possible use of PEL in the treatment of lipopolysaccharide (LPS)-mediated vascular inflammatory responses. The anti-inflammatory activities of PEL were determined by measuring permeability, neutrophils adhesion and migration, and activation of pro-inflammatory proteins in LPS-activated human umbilical vein endothelial cells (HUVECs) and mice. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.02.007DOI Listing
February 2019
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MicroRNA-449b-5p suppresses the growth and invasion of breast cancer cells via inhibiting CREPT-mediated Wnt/β-catenin signaling.

Chem Biol Interact 2019 Feb 7;302:74-82. Epub 2019 Feb 7.

Department of Ultrasound, The Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, 710004, China.

Accumulating evidence has suggested that microRNA-449b-5p (miR-449b-5p) plays an important role in the development and progression of multiple cancers. However, little is known about the role of miR-449b-5p in breast cancer. In this study, we aimed to investigate the expression level, biological function and underlying mechanism of miR-449b-5p in breast cancer. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.02.004DOI Listing
February 2019

Daphnetin activates the Nrf2-dependent antioxidant response to prevent arsenic-induced oxidative insult in human lung epithelial cells.

Chem Biol Interact 2019 Feb 6;302:93-100. Epub 2019 Feb 6.

Department of Respiratory Medicine, The First Hospital of Jilin University, Changchun, China. Electronic address:

NF-E2 p45-related factor 2 (Nrf2), which regulates the cellular antioxidant response, is a target for limiting tissue damage due to exposure to environmental toxicants, including arsenic. Daphnetin (Daph), a natural coumarin derivative, has been shown to induce remarkable antioxidant activity. The present study aimed to examine the protective effects and molecular mechanisms of Daph on arsenic-induced cytotoxicity in human lung epithelial cells. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.02.001DOI Listing
February 2019
1 Read

Effects of new tetrahydroquinoline-isoxazole hybrides on bioenergetics of hepatocarcinoma Hep-G2 cells and rat liver mitochondria.

Chem Biol Interact 2019 Feb 6. Epub 2019 Feb 6.

Grupo de Investigación en Bioquímica y Microbiología GIBIM, Escuela de Química, Universidad Industrial de Santander, A.A. 678, Bucaramanga, Colombia; Grupo de Investigación en Compuestos Orgánicos de Interés Medicinal CODEIM, Parque Tecnológico Guatiguará, Universidad Industrial de Santander, A. A. 678, Piedecuesta, Colombia. Electronic address:

New molecular hybrids were synthesized by combining tetrahydroquinoline (THQ) and isoxazole (ISX) scaffolds, in search for chemical structures with improved pharmacological properties. Our tetrahydroquinoline (THQ) and isoxazole (ISX) hybrids differ in the X and Y substituents: FM53 (X = H; Y= H), FM49 (X = CH; Y= OCH), FM50 (X = Cl; Y= H) and FM48 (X = Cl; Y= OCH). Aiming at exploring their bioactivity in liver cancer cells, in this paper we report the effect of four THQ-ISX hybrids on viability, respiration and oxidative stress in Hep-G2 human hepatoma cells. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.02.002DOI Listing
February 2019

Lead exposure inhibits osteoblastic differentiation and inactivates the canonical Wnt signal and recovery by icaritin in MC3T3-E1 subclone 14 cells.

Chem Biol Interact 2019 Feb 4. Epub 2019 Feb 4.

Department of Chinese Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, 510630, PR China. Electronic address:

Exposure to lead (Pb) poses a threat to human bone health, including changes in bone mineral composition and the inhibition of skeletal growth and bone maturation. However, little is known about how Pb directly affects osteoblasts. In this work, we found that sub-toxic Pb concentrations suppressed bone nodule formation and inhibited differentiation in MC3T3-E1 subclone 14 cells, as shown by decreased expression levels of the differentiation markers alkaline phosphatase (ALP), type 1 collagen (COL1), osteocalcin (OC), and runt-related transcription factor 2 (RUNX2). Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.039DOI Listing
February 2019

Retinyl esters are elevated in progeny of retinol dehydrogenase 11 deficient dams.

Chem Biol Interact 2019 Feb 4. Epub 2019 Feb 4.

Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingham, AL, 35294, USA. Electronic address:

Retinol dehydrogenase 11 (RDH11) is an NADPH-dependent retinaldehyde reductase that was previously reported to function in the visual cycle. Recently, we have shown that RDH11 contributes to the maintenance of retinol levels in extraocular tissues under conditions of vitamin A deficiency or reduced vitamin A availability. RDH11 is also expressed in the embryo. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.041DOI Listing
February 2019
1 Read

Penta-O-galloyl-β-D-glucose, a hydrolysable tannin from Radix Paeoniae Alba, inhibits adipogenesis and TNF-α-mediated inflammation in 3T3-L1 cells.

Chem Biol Interact 2019 Feb 2. Epub 2019 Feb 2.

College of Food Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China; Key Laboratory of Environment Correlative Food Science (Huazhong Agricultural University), Ministry of Education, China. Electronic address:

Penta-O-galloyl-β-D-glucose (PGG) was purified and identified from Radix Paeoniae Alba by HSCCC and HPLC/ESI-MS, and its inhibitory effects on adipogenesis and TNF-α-induced inflammation were assessed in 3T3-L1 cell line. The results showed that PGG dose-dependently reduced intracellular lipids accumulation, and this involved decrease the expression levels of major adipogenic markers, PPARγ, C/EBP α, through MAPKs inhibition. This was accompanied by a reduction of lipogenic genes, ACC, FAS, and SCD-1, involved in fatty acid synthesis. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.037DOI Listing
February 2019
1 Read

Ethanol induces skin hyperpigmentation in mice with aldehyde dehydrogenase 2 deficiency.

Chem Biol Interact 2019 Feb 2;302:61-66. Epub 2019 Feb 2.

Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.

Alcohol induces various cutaneous changes, such as palmar erythema and jaundice. However, alcohol-induced skin hyperpigmentation due to melanin deposition has not been reported. Aldehyde dehydrogenase 2 (ALDH2), one of 19 human ALDH isozymes, metabolizes endogenous and exogenous aldehydes to their respective carboxylic acids. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.035DOI Listing
February 2019
2 Reads

Substitution of cysteine-153 ligated to the catalytic zinc in yeast alcohol dehydrogenase with aspartic acid and analysis of mechanisms of related medium chain dehydrogenases.

Chem Biol Interact 2019 Feb 2. Epub 2019 Feb 2.

Department of Biochemistry, The University of Iowa, Iowa City, IA, 52242, USA. Electronic address:

The catalytic zincs in complexes of horse liver and yeast alcohol dehydrogenases (ADH) with NAD and the substrate analogue, 2,2,2-trifluoroethanol, are ligated to two cysteine residues and one histidine residue from the protein and the oxygen from the alcohol. The zinc facilitates deprotonation of the alcohol and is essential for catalysis. In the yeast apoenzyme, the zinc is coordinated to a nearby glutamic acid, which is displaced by the alcohol in the complex with NAD. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.040DOI Listing
February 2019
2 Reads

miR-543 inhibites cervical cancer growth and metastasis by targeting TRPM7.

Chem Biol Interact 2019 Jan 30;302:83-92. Epub 2019 Jan 30.

Department of Gynecology, Shaanxi Provincial People's Hospital, 710068, Shaanxi, China.

Dysregulation of miR-543 has been implicated to play crucial roles in various human cancers. However, the function of miR-543 involved in cervical cancer (CC) progress remains largely unknown. Thus, this study aimed to explore the potential role of miR-543 and the underlying mechanisms in human CC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797183143
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http://dx.doi.org/10.1016/j.cbi.2019.01.036DOI Listing
January 2019
3 Reads

Cooperative regulation of mouse aldose reductase (AKR1B3) gene transcription by Nrf2, TonEBP, and c-jun.

Chem Biol Interact 2019 Jan 29;302:36-45. Epub 2019 Jan 29.

Laboratory of Biochemistry, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Osaka 584-8540, Japan.

Aldose reductase (AR), a member of aldo-keto reductase family, is the rate-limiting enzyme in the polyol pathway, and is known to play a key role in the pathogenesis of diabetic complications. AR also catalyzes the reduction of reactive aldehydes, thereby detoxifying endogenous as well as xenobiotic aldehydes in various tissues. The transcription of the AR gene was previously shown to be augmented by various stimuli including osmotic and oxidative stresses. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.024DOI Listing
January 2019
1 Read

Oxidized phospholipids in Doxorubicin-induced cardiotoxicity.

Chem Biol Interact 2019 Jan 29. Epub 2019 Jan 29.

Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB, Canada; Department of Human Anatomy & Cell Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. Electronic address:

Doxorubicin (Dox), a widely used chemotherapy drug, can also cause cardiotoxic effects leading to heart failure. The excessive oxidative stress caused by Dox results in the modification of a variety of cellular molecules, including phospholipids. In cardiomyocytes, Dox increases oxidation of a species of phospholipids, phosphatidylcholine, which has been associated with increased cell death. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.032DOI Listing
January 2019

The oral administration of silver nanoparticles activates the kynurenine pathway in rat brain independently of oxidative stress.

Chem Biol Interact 2019 Jan 29;302:22-27. Epub 2019 Jan 29.

School of Medicine, All Saints University, Hillsborough Street, Roseau, Dominica.

In this work, we determined whether oxidative stress contributed to the activation of the kynurenine pathway by AgNPs. Male Wistar rats weighing between 130 and 146 g were randomly assigned into six groups. Animals in the negative control group were orally administered distilled water while, the other treatment groups were respectively given AgNPs (25 and 50 mg/kg bw) alone or in combination with Trolox (100 mg/kg bw). Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.034DOI Listing
January 2019

Cell-specific regulation of Nrf2 during ROS-Dependent cell death caused by 2,3,5-tris(glutathion-S-yl)hydroquinone (TGHQ).

Chem Biol Interact 2019 Jan 28;302:1-10. Epub 2019 Jan 28.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, 259, Mack Ave, Detroit, MI, 48201, USA. Electronic address:

2,3,5-tris(Glutathion-S-yl)hydroquinone (TGHQ), a potent nephrotoxic and nephroncarcinogenic metabolite of benzene and hydroquinone, retains the ability to redox cycle and create oxidative stress. We have previously detected that TGHQ induces ROS-dependent necrotic or apoptotic cell death in renal epithelial HK-2 and human leukemic HL-60 cells respectively. Herein, we sought to determine the nature of the Nrf2 regulation in HK-2 and HL-60 cells undergoing TGHQ-mediated ROS-dependent cell death, due to the key role of Nrf2 in oxidative stress. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.027DOI Listing
January 2019

Buparlisib is a novel inhibitor of daunorubicin reduction mediated by aldo-keto reductase 1C3.

Chem Biol Interact 2019 Jan 28;302:101-107. Epub 2019 Jan 28.

Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove, CZ-50005, Czech Republic. Electronic address:

Buparlisib is a pan-class I phosphoinositide 3-kinase (PI3K) inhibitor and is currently under clinical evaluation for the treatment of different cancers. Because PI3K signalling is related to cell proliferation and resistance to chemotherapy, new therapeutic approaches are focused on combining PI3K inhibitors with other anti-cancer therapeutics. Carbonyl-reducing enzymes catalyse metabolic detoxification of anthracyclines and reduce their cytotoxicity. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.026DOI Listing
January 2019
2.577 Impact Factor

Dimethylfumarate ameliorates hepatic injury and fibrosis induced by carbon tetrachloride.

Chem Biol Interact 2019 Jan 28;302:53-60. Epub 2019 Jan 28.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.

The current study was designed to assess the antifibrotic effect of dimethylfumarate (DMF) on CCl-induced hepatic injury in rats. Hepatic injury was induced by intraperitoneal twice weekly injection of CCl for 2 and 3 months. DMF was administered orally during the last 4 weeks in each model. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.029DOI Listing
January 2019

Irisin attenuates angiotensin II-induced cardiac fibrosis via Nrf2 mediated inhibition of ROS/ TGFβ1/Smad2/3 signaling axis.

Chem Biol Interact 2019 Jan 29;302:11-21. Epub 2019 Jan 29.

Department of Cardiology, Second Affiliated Hospital of Air Forced Military Medical University, Xi'an, Shaanxi Province, 710068, China; Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, 710068, China. Electronic address:

Angiotensin II-related cardiac fibrosis is one of the key pathological changes of the hypertrophied left ventricle in various heart disease. Irisin was recently reported to confer cardio-protective and anti-oxidative effects, while whether it can reverse the renin-angiotensin-aldosterone system(RAAS) activation related(angiotensin II-induced) cardiac fibrosis is unknown. In this study, we found that angiotensin II-induced cardiac dysfunction and fibrotic responses were dampened by irisin treatment in mice. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.031DOI Listing
January 2019

The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells.

Chem Biol Interact 2019 Jan 28;302:28-35. Epub 2019 Jan 28.

Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan; Center for Cell Therapy and Regeneration Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

The major obstacle in current cancer therapy is the existence of cancer stem cells (CSCs), which are responsible for therapeutic resistance and contribute to metastasis and recurrence. Identification of reliable biomarkers for diagnostic and therapeutic targets is necessary for drug development and cancer treatment. In this study, we identified that the antipsychotic chlorpromazine (CPZ) exhibited potent anti-breast cancer and anti-CSC capabilities. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.033DOI Listing
January 2019

The role of MAPK signaling pathway in selenium amelioration of high fat/high cholesterol diet-induced tauopathy in rats.

Chem Biol Interact 2019 Jan 26;302:108-116. Epub 2019 Jan 26.

Department of Pharmacology, Faculty of Medicine, Ain Shams University, Egypt. Electronic address:

Background: MAP kinases, CREB, and Tau are signaling molecules among downstream synaptic targets involved in synaptic function, memory formation and cognition.

Purpose: Here we investigate the neuro-protective effect of selenium in HFHCD induced tauopathy and cognitive impairment in rats. The study was focused on the effects on synaptic plasticity related molecules in hippocampus, which in turn may be the mechanism responsible for underlying behavior alterations. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.022DOI Listing
January 2019

Microarray assisted toxicological investigations of boron carbide nanoparticles on human primary alveolar epithelial cells.

Chem Biol Interact 2019 Feb 24;300:131-137. Epub 2019 Jan 24.

Department of Medical Genetics, Medical Faculty, Atatürk University, Erzurum, Turkey.

It is important to understand the adverse effects of nanoparticles on human health and to prepare risk reports for widely used nanoscale materials. Synthesis, characterization and cytotoxicity evaluation of BC nanoparticles were performed on HPAEpiC since, first encounter with nanoparticles would generally happen through lung by inhaling chemicals. BC nanoparticles were synthesized via chemical vapor deposition techniques and characterized by using transmission electron microscope (TEM), scanning electron microscope (SEM) and X-ray crystallography (XRD). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797183152
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http://dx.doi.org/10.1016/j.cbi.2019.01.021DOI Listing
February 2019
4 Reads

Role of aldose reductase in diabetes-induced retinal microglia activation.

Chem Biol Interact 2019 Jan 23;302:46-52. Epub 2019 Jan 23.

Department of Ophthalmology, Sue Anschutz-Rodgers Eye Center, University of Colorado, Anschutz Medical Campus, Aurora, CO, 80045, USA; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, CO, 80045, USA. Electronic address:

Diabetes-induced hyperglycemia plays a key pathogenic role in degenerative retinal diseases. In diabetic hyperglycemia, aldose reductase (AR) is elevated and linked to the pathogenesis of diabetic retinopathy (DR) and cataract. Retinal microglia (RMG), the resident immune cells in the retina, are thought to contribute to the proinflammatory phenotype in the diabetic eye. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797183121
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http://dx.doi.org/10.1016/j.cbi.2019.01.020DOI Listing
January 2019
4 Reads

Taurine protected AsO-induced the activation of hepatic stellate cells through inhibiting PPARα-autophagy pathway.

Chem Biol Interact 2019 Feb 21;300:123-130. Epub 2019 Jan 21.

Department of Occupational and Environment Health, Dalian Medical University, 9 W Lvshun South Road, Dalian, 116044, PR China; Global Health Research Center, Dalian Medical University, 9 W Lvshun South Road, Dalian, 116044, PR China. Electronic address:

The activation of hepatic stellate cells (HSCs) is a key event in the development of hepatic fibrosis caused by arsenic. However, it is unclear how arsenic induces the activation of HSCs. In the present study, we found that arsenic trioxide (AsO) induced liver tissue damage, stimulated autophagy and HSCs activation, and increased collagen accumulation in the liver of mice. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797183142
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http://dx.doi.org/10.1016/j.cbi.2019.01.019DOI Listing
February 2019
2 Reads

Form and function in carbonyl metabolizing enzymes.

Authors:
Aruni Bhatnagar

Chem Biol Interact 2019 Feb 17;300:159-160. Epub 2019 Jan 17.

Envirome Institute, University of Louisville, Louisville, KY, 40202, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2019.01.017DOI Listing
February 2019
1 Read

SIRT6 protects retinal ganglion cells against hydrogen peroxide-induced apoptosis and oxidative stress by promoting Nrf2/ARE signaling via inhibition of Bach1.

Chem Biol Interact 2019 Feb 17;300:151-158. Epub 2019 Jan 17.

Department of Ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China. Electronic address:

Oxidative stress-induced damage of retinal ganglion cells (RGCs) is a major contributor to retinal degenerative diseases, such as glaucoma. Sirtuin 6 (SIRT6) has emerged as a cytoprotective protein against various insults. However, whether SIRT6 exerts a protective effect against oxidative stress-damaged RGCs remains unknown. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.018DOI Listing
February 2019
2 Reads

Dietary canolol induces apoptosis in human cervical carcinoma HeLa cells through ROS-MAPK mediated mitochondrial signaling pathway: In vitro and in vivo.

Chem Biol Interact 2019 Feb 14;300:138-150. Epub 2019 Jan 14.

Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Oil Crops and Lipids Process Technology National & Local Joint Engineering Laboratory, Key Laboratory of Oilseeds Processing, Ministry of Agriculture, Hubei Key Laboratory of Lipid Chemistry and Nutrition, Wuhan, 430062, China.

Canolol (4-vinylsyringol), extracted form crude canola oil, is the promising drug toward cancer prevention and treatment. The current studies focus on the role of COX-2 signaling pathway in canolol-induced apoptosis in cancer cells. It is still unknown whether mitochondria and MAPK signaling pathways are involved. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.016DOI Listing
February 2019
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The induction of Maspin expression by a glucosamine-derivative has an antiproliferative activity in prostate cancer cell lines.

Chem Biol Interact 2019 Feb 11;300:63-72. Epub 2019 Jan 11.

Dept. of Biochemical Sciences, Sapienza University of Roma, P.le Aldo Moro, 5, 00185, Roma, Italy. Electronic address:

Mammary serine protease inhibitor or Maspin has been characterized as a class II tumor suppressor gene in several cancer types, among them prostate cancer (CaP). Androgen ablation is an effective therapy for CaP, but with short-term effectiveness, thus new therapeutic strategies are actively sought. The present study is aimed to explore the effects of a glucosamine derivative, 2-(N-Carbobenzyloxy)l-phenylalanylamido-2-deoxy-β-d-glucose (NCPA), on two CaP cell lines, PC3 and LNCaP. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.014DOI Listing
February 2019
2 Reads

Downregulation of microRNA-532-5p promotes the proliferation and invasion of bladder cancer cells through promotion of HMGB3/Wnt/β-catenin signaling.

Chem Biol Interact 2019 Feb 11;300:73-81. Epub 2019 Jan 11.

Department of Clinical Laboratory, The First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China. Electronic address:

Accumulating evidence has shown that altered expression of microRNA-532-5p (miR-532-5p) is involved in the development and progression of various cancers. However, little is known about the role of miR-532-5p in bladder cancer. In this study, we aimed to investigate the expression, biological function, and regulatory mechanism of miR-532-5p in bladder cancer. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.015DOI Listing
February 2019
1 Read

Combined treatment with vitamin K2 and PTH enhanced bone formation in ovariectomized rats and increased differentiation of osteoblast in vitro.

Chem Biol Interact 2019 Feb 10;300:101-110. Epub 2019 Jan 10.

Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address:

Osteoporosis is accompanied by insufficient osteogenic capacity. Several lines of evidence suggested that solutions to enhance osteoblastogenesis were important strategies for osteoporotic bone defect repair. This study investigated the effect of combined treatment with vitamin K2 and PTH on bone formation in calvarial bone defect in osteoporotic rats and its influence on osteoblast in vitro. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797183056
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http://dx.doi.org/10.1016/j.cbi.2019.01.012DOI Listing
February 2019
6 Reads

miR-145-5p is associated with smoke-related chronic obstructive pulmonary disease via targeting KLF5.

Chem Biol Interact 2019 Feb 9;300:82-90. Epub 2019 Jan 9.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.

Increasing evidence illustrate that dysregulation of microRNAs (miRNAs) is involved in the pathogenesis of chronic obstructive pulmonary disease (COPD), which is mainly resulted from cigarette smoke (CS) exposure. However, the role of miR-145-5p in CS-mediated COPD remains largely unknown. Thus, the aim of this study was to investigate the expression level of miR-145-5p in 31 human lung tissues samples, and to explore its regulatory role in the apoptosis and inflammation of human bronchial epithelial cells (HBECs) following CS extract (CSE) exposure. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.011DOI Listing
February 2019
2 Reads

Chronic intake of moderate fat-enriched diet induces fatty liver and low-grade inflammation without obesity in rabbits.

Chem Biol Interact 2019 Feb 9;300:56-62. Epub 2019 Jan 9.

Laboratorio de Inmunología, Unidad de Morfología y Función, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México Tlalnepantla, Estado de México, México. Electronic address:

Non-Alcoholic Fatty Liver Disease (NAFLD) is the cause of chronic liver disease. Even though NAFLD is strongly associated with obesity and metabolic syndrome, there is a proportion of patients who develop this condition in the absence of obesity and the underlying mechanisms are poorly understood. We investigated early events in the pathogenesis of non-obese NAFLD, analyzing the impact of the chronic intake of a moderate fat-enriched diet on hepatic lipid accumulation and their relationship with inflammation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797183124
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http://dx.doi.org/10.1016/j.cbi.2019.01.004DOI Listing
February 2019
3 Reads

Quercetin inhibits human metastatic ovarian cancer cell growth and modulates components of the intrinsic apoptotic pathway in PA-1 cell line.

Chem Biol Interact 2019 Feb 9;300:91-100. Epub 2019 Jan 9.

Department of Endocrinology, Dr. A.L.M. Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, 600 113, Tamil Nadu, India. Electronic address:

Ovarian cancer is the leading cause of gynaecology related cancer death worldwide. It is often diagnosed with an advanced stage. Apoptosis is a process of programmed cell death controlled by cell cycle machinery and several signaling pathways. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797183106
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http://dx.doi.org/10.1016/j.cbi.2019.01.008DOI Listing
February 2019
7 Reads

Membrane hyperpolarization and depolarization of rat thymocytes by azoxystrobin, a post harvest fungicide.

Chem Biol Interact 2019 Feb 7;300:35-39. Epub 2019 Jan 7.

Faculty of Bioscience and Bioindustry, Tokushima University, Tokushima, 770-8513, Japan; Regional Sciences, Graduate School of Integrated Arts and Sciences, Tokushima University, Tokushima, 770-8502, Japan. Electronic address:

Azoxystrobin, a broad-spectrum fungicide, has been increasingly used in the agricultural industry. In Japan in 2018, azoxystrobin at five times the normal limit was detected in a shipment of Australian barley that had been used in food products. Therefore, the effects of azoxystrobin need to be carefully examined to predict potential adverse reactions in humans. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.006DOI Listing
February 2019
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The aggravating effect of selenium deficiency on T-2 toxin-induced damage on primary cardiomyocyte results from a reduction of protective autophagy.

Chem Biol Interact 2019 Feb 7;300:27-34. Epub 2019 Jan 7.

College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, PR China. Electronic address:

Selenium deficiency and T-2 toxin exposure may contribute to the development of Keshan disease characterized by congestive cardiomyopathy. The aim of this study was to explore the role of autophagy in the aggravation of selenium deficiency on T-2 toxin-induced damages on primary cardiomyocyte. Our present study demonstrated that 0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797183160
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http://dx.doi.org/10.1016/j.cbi.2019.01.009DOI Listing
February 2019
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Anthocyanins and metabolites resolve TNF-α-mediated production of E-selectin and adhesion of monocytes to endothelial cells.

Chem Biol Interact 2019 Feb 3;300:49-55. Epub 2019 Jan 3.

Università degli Studi di Milano, Department of Food, Environmental and Nutritional Sciences- Division of Human Nutrition, Milan, Italy.

This study investigated the capacity of an anthocyanin-rich fraction (ACN-RF) from blueberry, single anthocyanins (cyanidin, delphinidin and malvidin-3-glucoside; Cy, Dp and Mv-3-glc) and related metabolites (protocatechuic, gallic and syringic acid; PrA, GA and SA) to resolve an inflammation-driven adhesion of monocytes (THP-1) on endothelial cell (HUVECs) and secretion of cell adhesion molecules E-selectin and vascular cell adhesion molecule 1 (VCAM-1). The adhesion of THP-1 to HUVECs was induced by tumour necrosis factor α (TNF-α, 100 ng mL). Subsequently, ACN-RF, single ACNs and metabolites (from 0. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.002DOI Listing
February 2019
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Saikosaponin d ameliorates pancreatic fibrosis by inhibiting autophagy of pancreatic stellate cells via PI3K/Akt/mTOR pathway.

Chem Biol Interact 2019 Feb 3;300:18-26. Epub 2019 Jan 3.

Department of Cell and Molecular Biology, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Tianjin, 300100, PR China; Nankai Clinical College, Tianjin Medical University, Tianjin, 300107, PR China. Electronic address:

Chronic pancreatitis is characterized by pancreatic fibrosis, associated with excessive activation of pancreatic stellate cells (PSCs) and increased expression of transforming growth factor-β1 (TGF-β1). Recently, our studies have shown that autophagy inhibitor could inhibit PSCs activation and reduce collagen secretion. Saikosaponin d (SSd), the major active component of bupleurum falcatum (a medicinal plant), has anti-fibrosis effects in liver. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797183103
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http://dx.doi.org/10.1016/j.cbi.2019.01.005DOI Listing
February 2019
5 Reads

Synergistic anticancer activity of doxorubicin and piperlongumine on DU-145 prostate cancer cells - The involvement of carbonyl reductase 1 inhibition.

Chem Biol Interact 2019 Feb 3;300:40-48. Epub 2019 Jan 3.

Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland.

One of the causes of therapeutic failure of chemotherapy is cancer cell resistance. In the case of anthracyclines, many resistance mechanisms have been described. One of them assumes the role of carbonyl reductase 1 (CBR1), a cytosolic enzyme that is responsible for the biotransformation process of anthracyclines to less active, undesirable metabolites. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.003DOI Listing
February 2019
1 Read
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