7,491 results match your criteria Chemico-biological interactions[Journal]


Computer-designed active human butyrylcholinesterase double mutant with a new catalytic triad.

Chem Biol Interact 2019 Apr 19. Epub 2019 Apr 19.

Kazan Federal University, Neuropharmacology Laboratory, Kremlevskaya Str, 18, Kazan, 420008, Russia. Electronic address:

A computer-designed mutant of human butyrylcholinesterase (BChE), N322E/E325G, with a novel catalytic triad was made. The catalytic triad of the wild-type enzyme (S198·H438·E325) was replaced by S198·H438·N322E in silico. Molecular dynamics for 1. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.019DOI Listing

Plantamajoside attenuates isoproterenol-induced cardiac hypertrophy associated with the HDAC2 and AKT/ GSK-3β signaling pathway.

Chem Biol Interact 2019 Apr 19. Epub 2019 Apr 19.

Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning, China; Emergency Medicine Department of General Hospital of Northern Theater Command, Laboratory of Rescue Center of Severe Wound and Trauma PLA, 83 Wenhua Road, Shenhe District, Shenyang, China. Electronic address:

As a compensatory response to cardiac overload, cardiac hypertrophy is closely associated with the occurrence and development of a variety of cardiovascular diseases, in which histone deacetylase 2 (HDAC2) has been reported to play an important role. Plantamajoside (PMS) is an active component extracted from Herba Plantaginis, which is a traditional Chinese medicine, and many biological activities of PMS have been reported. Here, we investigated the effects and mechanism of PMS on isoproterenol (ISO)-induced cardiac hypertrophy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797183173
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http://dx.doi.org/10.1016/j.cbi.2019.04.024DOI Listing

Ameliorative effect of zinc supplementation on compromised small intestinal health in streptozotocin-induced diabetic rats.

Chem Biol Interact 2019 Apr 19. Epub 2019 Apr 19.

Department of Biochemistry, CSIR - Central Food Technological Research Institute, Mysore, 570 020, India. Electronic address:

Zinc depletion during diabetes postulates a role for zinc nutrition in the management of associated complications. The present study evaluated zinc supplementation for countering the compromised intestinal integrity through moderation of oxidative stress and suppression of stress-stimulated inflammatory proliferation in streptozotocin-induced diabetic rats. Diabetic rats were provided with supplemental zinc for six weeks (5 and 10-times of normal level). Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.018DOI Listing

Inhibitory effect of mabuterol on proliferation of rat ASMCs induced by PDGF-BB via regulating [Ca]i and mitochondrial fission/fusion.

Chem Biol Interact 2019 Apr 19. Epub 2019 Apr 19.

School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China. Electronic address:

This study is aimed to investigate whether Mabuterol (Mab) inhibits proliferation of airway smooth muscle cells (ASMCs) induced by platelet-derived growth factor BB (PDGF-BB) and how far it is related to mitochondrial fission/fusion and intracellular calcium if it comes into play. To explore the mechanism of Mab's antagonizing the proliferation, Mdivi-1, DRP1 inhibitor, which has an inhibitory effect on mitochondrial fission, is used to compare with Mab. Cell viability was measured by either MTT or CCK-8. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.023DOI Listing

6-Gingerol abates benzo[a]pyrene-induced colonic injury via suppression of oxido-inflammatory stress responses in BALB/c mice.

Chem Biol Interact 2019 Apr 17. Epub 2019 Apr 17.

Drug Metabolism & Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria. Electronic address:

Exposure to benzo[a]pyrene (BaP), the most toxic polycyclic aromatic hydrocarbon and a procarcinogen, is a global health concern which necessitates preventive measures [6].-Gingerol (6-G), the most pharmacologically active constituent of ginger has been reported to promote gut health in various experimental settings. This study investigated the role of 6-G in BaP-induced colonic oxidative and inflammatory stress responses in mice. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.026DOI Listing

A contemporary biological pathway of islet amyloid polypeptide for the management of diabetic dementia.

Chem Biol Interact 2019 Apr 17. Epub 2019 Apr 17.

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney (UTS), Ultimo, NSW 2007, Australia; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) & School of Biomedical Sciences and Pharmacy, The University of Newcastle (UoN), Callaghan, NSW 2308, Australia. Electronic address:

Major challenges of dealing elder patients with diabetes mellitus (DM) are the individualization of consideration in persons with various comorbid types of conditions. In spite of the fact that microvascular and macrovascular problems associated with DM are well documented, there is only a few numbers of reports viewing different conditions, for example, cognitive dysfunction. Cognitive dysfunction is of specific significance due to its effect on self-care and quality of life. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.022DOI Listing

Pro-apoptotic and anti-inflammatory effects of araloside A on human rheumatoid arthritis fibroblast-like synoviocytes.

Chem Biol Interact 2019 Apr 17. Epub 2019 Apr 17.

Department of Rheumatology and Immunology, Huaihe Hospital of Henan University, Kaifeng, 475000, Henan, China. Electronic address:

Rheumatoid arthritis fibroblast-like synoviocytes play an essential role in the occurrence and progression of rheumatoid arthritis. As the main pharmacologically active components of Aralia taibaiensis, total saponins, particularly triterpenoid saponins, have been shown to possess multiple pharmacological activities including relieving rheumatism. However, the effect of araloside A, a triterpenoid saponin extracted from the root bark of Aralia taibaiensis, on rheumatoid arthritis remains unknown. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.025DOI Listing

Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes.

Chem Biol Interact 2019 Apr 17. Epub 2019 Apr 17.

Institute for Medical Research and Occupational Health, Ksaverska cesta 2, HR-10000 Zagreb, Croatia. Electronic address:

Bispyridinium oximes with one (K865, K866, K867) or two (K868, K869, K870) ortho-positioned chlorine moiety, analogous to previously known K027, K048 and K203 oximes, and potent reactivators of human acetylcholinesterase (AChE) inhibited by nerve agents, were tested in the reactivation of human butyrylcholinesterase (BChE) inhibited by sarin, cyclosarin, VX, and tabun. A previously highlighted AChE reactivator, dichlorinated bispyridinium oxime with propyl linker (K868), was tested in more detail for reactivation of four nerve agent-BChE conjugates. Its BChE reactivation potency was showed to be promising when compared to the standard oximes used in medical practice, asoxime (HI-6) and pralidoxime (2-PAM), especially in case of sarin and tabun. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.020DOI Listing

Long non-coding RNA-p21 regulates MPP-induced neuronal injury by targeting miR-625 and derepressing TRPM2 in SH-SY5Y cells.

Chem Biol Interact 2019 Apr 17. Epub 2019 Apr 17.

Department of Blood Transfusion, Central Hospital of Linyi, No. 17, Health Road, Yishui County, 276400, Linyi City, Shandong Province, China. Electronic address:

Parkinson's disease (PD), the second most prevalent age-related neurodegenerative disease, occurs as a result of the loss of dopaminergic neurons in the substantia nigra. Long non-coding RNA-p21 (lnc-p21) has been demonstrated to be upregulated in PD. However, its role in PD is unknown. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.017DOI Listing

Inhibition of aldose reductase activity stimulates starvation induced autophagy and clears aldehyde protein adducts.

Chem Biol Interact 2019 Apr 15;306:104-109. Epub 2019 Apr 15.

Envirome Institute, Department of Medicine, University of Louisville, Louisville, KY, USA; Diabetes and Obesity Center, Department of Medicine, University of Louisville, Louisville, KY, USA. Electronic address:

Autophagy is a dynamic recycling process that eliminates damaged proteins and cellular organelles to maintain cellular homeostasis. Aldose reductase (AR) catalyzes conversion of glucose to sorbitol. It also catalyzes the reduction of a broad array of saturated and unsaturated aldehydes. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.014DOI Listing

MiR-199-3p promotes ERK-mediated IL-10 production by targeting poly (ADP-ribose) Polymerase-1 in patients with systemic lupus erythematosus.

Chem Biol Interact 2019 Apr 13. Epub 2019 Apr 13.

Department of Nephrology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, PR China. Electronic address:

MicroRNAs (miRNAs) have been implicated in both biological and pathological processes in patients with systemic lupus erythematosus (SLE). Previous studies have demonstrated dysregulated expression of miR-199-3p, interleukin (IL)-10, and poly (ADP-ribose) polymerase-1 (PARP-1) in SLE. However, the underlying mechanisms of these aberrations have not been fully elucidated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797183128
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http://dx.doi.org/10.1016/j.cbi.2019.04.015DOI Listing
April 2019
3 Reads

The effect of hesperidin supplementation on inflammatory markers in human adults: A systematic review and meta-analysis of randomized controlled clinical trials.

Chem Biol Interact 2019 Apr 13. Epub 2019 Apr 13.

Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address:

Background: Hesperidin (a flavanone found in citrus fruits) supplementation is suggested to inversely affect inflammation; however, clinical trials have led to inconsistent results.

Objective: To examine the effect of hesperidin supplementation on inflammatory markers using systematic review and meta-analysis of randomized controlled clinical trials (RCTs).

Patient And Methods: Online databases including PubMed, Scopus, ISI Web of Science, and Google Scholar were searched up to December 2018. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797193014
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http://dx.doi.org/10.1016/j.cbi.2019.04.016DOI Listing
April 2019
2 Reads

Carbonyl reductase sniffer from the model organism daphnia: Cloning, substrate determination and inhibitory sensitivity.

Chem Biol Interact 2019 Apr 13. Epub 2019 Apr 13.

Institute of Toxicology and Pharmacology for Natural Scientists, University Medical School Schleswig-Holstein, Kiel, Germany. Electronic address:

Carbonyl reductases (CRs) represent a fundamental enzymatic defense mechanism against oxidative stress. While commonly two carbonyl reductases (CBR1 and CBR3) are found in mammalian genomes, invertebrate model organisms like Drosophila melanogaster express no CR but a functional homolog to human CBR1, termed sniffer. The importance of sniffer could be demonstrated in D. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.011DOI Listing

Development of a long-acting Fc-fused cocaine hydrolase with improved yield of protein expression.

Chem Biol Interact 2019 Apr 12;306:89-95. Epub 2019 Apr 12.

Molecular Modeling and Biopharmaceutical Center and Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA. Electronic address:

Human butyrylcholinesterase (BChE) is known as a safe and effective protein for detoxification of organophosphorus (OP) nerve agents. Its rationally designed mutants with considerably improved catalytic activity against cocaine, known as cocaine hydrolases (CocHs), are recognized as the most promising drug candidates for the treatment of cocaine abuse. However, it is a grand challenge to efficiently produce active recombinant BChE and CocHs with a sufficiently long biological half-life. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797193035
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http://dx.doi.org/10.1016/j.cbi.2019.04.012DOI Listing
April 2019
3 Reads

Evaluation of a robust engineered enzyme towards organophosphorus insecticide bioremediation using planarians as biosensors.

Chem Biol Interact 2019 Apr 12;306:96-103. Epub 2019 Apr 12.

Aix Marseille Université, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France. Electronic address:

Organophosphorus compounds (OPs) are neurotoxic molecules developed as insecticides and chemical warfare nerve agents (CWNAs). They are covalent inhibitors of acetylcholinesterase (AChE), a key enzyme in central and peripheral nervous systems and are responsible for numerous poisonings worldwide. Many animal models have been studied over the years but finding a suitable in vivo model to account for both acute toxicity and long-term exposure remains a topical issue. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.013DOI Listing

4-PBA prevents diabetic muscle atrophy in rats by modulating ER stress response and ubiquitin-proteasome system.

Chem Biol Interact 2019 Apr 10;306:70-77. Epub 2019 Apr 10.

Biochemistry Division, National Institute of Nutrition, Hyderabad, India.. Electronic address:

Purpose: Skeletal muscle is severely affected in diabetes leading to muscle atrophy. Previously we reported the role of ER stress in muscle atrophy due to hyperglycemia. Hence, in the present study, we investigated the effect of a classical ER stress inhibitor, 4-phenylbutyric acid (PBA), on muscle atrophy in diabetic rats. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.009DOI Listing

ERK1/2 mediates the lipopolysaccharide-induced upregulation of FGF-2, uPA, MMP-2, MMP-9 and cellular migration in cardiac fibroblasts.

Chem Biol Interact 2019 Apr 11;306:62-69. Epub 2019 Apr 11.

Department of Biotechnology, Asia University, Taichung, Taiwan; College of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien, Taiwan; Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan. Electronic address:

Myocardial fibrosis is a critical event during septic shock. Upregulation in the fibrosis signaling cascade proteins such as fibroblast growth factor (FGF), urokinase plasminogen activator (uPA), tissue plasminogen activator (tPA) and activation of matrix metalloproteinases (MMPs) are widely associated with the development of myocardial infarction, dilated cardiomyopathy, cardiac fibrosis and heart failure. However, evidences suggest that the common upstream mediators of fibrosis cascade play little role in cardiac fibrosis induced by LPS; further, it is unknown if LPS directly triggers the expressions and/or activity of FGF-2, uPA, tPA, MMP-2 and MMP-9 in cardiac fibroblasts. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.010DOI Listing
April 2019
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Diacerein protects against glycerol-induced acute kidney injury: Modulating oxidative stress, inflammation, apoptosis and necroptosis.

Chem Biol Interact 2019 Apr 8;306:47-53. Epub 2019 Apr 8.

Department of Internal Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.

Necroptosis is suggested to have an important role in the pathogenesis of rhabdomyolysis induced acute kidney injury (AKI). In this study, the renoprotective effect of diacerein on glycerol-induced AKI was investigated. Twenty four male albino rats were included in this study and divided into four groups: (group I) saline control group, (group II) glycerol-treated group, (groups III&IV) diacerein + glycerol -treated groups (25 and 50 mg/kg/day) respectively. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.008DOI Listing
April 2019
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HO-1 mediates the anti-inflammatory actions of Sulforaphane in monocytes stimulated with a mycoplasmal lipopeptide.

Chem Biol Interact 2019 Apr 6;306:10-18. Epub 2019 Apr 6.

Institute of Pathogenic Biology, Hengyang Medical College, University of South China, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, 421001, China. Electronic address:

Exposure to Mycoplasma pneumoniae leads to lung inflammation through a host defense pathway. Increasing evidence has indicated that the mycoplasma-derived membrane lipoprotein, or its analogue macrophage-activating lipopeptide-2 (MALP-2), excretes LPS as an immune system-stimulating substance and plays a crucial role in pathological injury during M. pneumoniae infection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797183147
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http://dx.doi.org/10.1016/j.cbi.2019.04.007DOI Listing
April 2019
3 Reads

Inhibitory effects of antihypertensive drugs on human cytochrome P450 2J2 activity: Potent inhibition by azelnidipine and manidipine.

Chem Biol Interact 2019 Apr 6;306:1-9. Epub 2019 Apr 6.

Department of Pharmacy, Shinshu University Hospital, 3-1-1 Asahi, Matsumoto 390-8621, Japan; Department of Biochemical Pharmacology and Toxicology, Graduate School of Medicine, Shinshu University, 3-1-1 Asahi, Matsumoto 390-8621, Japan.

The inhibitory effects of antihypertensive drugs (dihydropyridine calcium channel blockers, angiotensin II receptor blockers, and angiotensin-converting enzyme inhibitors) on cytochrome P450 2J2 (CYP2J2) activity were examined. Amlodipine, azelnidipine, barnidipine, benidipine, cilnidipine, efonidipine, felodipine, manidipine, nicardipine, nifedipine, nilvadipine, nisoldipine, nitrendipine, telmisartan, delapril, and quinapril inhibited luciferin-2J2/4F12 O-dealkylase activity of recombinant human CYP2J2 in a concentration-dependent manner (IC = 0.116-9. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.005DOI Listing

Quercetin enhances the antitumor activity of trichostatin A through up-regulation of p300 protein expression in p53 null cancer cells.

Chem Biol Interact 2019 Apr 5;306:54-61. Epub 2019 Apr 5.

Department of Nutrition, Chung Shan Medical University, Taichung, Taiwan; Department of Nutrition, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address:

In the present study, we investigated the p53-independent mechanism by which quercetin (Q) increased apoptosis in human lung cancer H1299 cells exposed to trichostatin A (TSA), a histone deacetylase inhibitor. We also investigated the role of Q in increasing the acetylation of histones H3 and H4 and the possible mechanism. Q at 5 μM significantly increased apoptosis by 88% in H1299 cells induced by TSA at 72 h. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.006DOI Listing

Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents: Kinetic characterization and effect on human cancer cells.

Chem Biol Interact 2019 Apr 5. Epub 2019 Apr 5.

Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona, E-08193, Bellaterra, Barcelona, Spain. Electronic address:

Aldehyde dehydrogenases (ALDHs) are enzymes catalyzing the NAD(P)-dependent oxidation of aldehydes to their corresponding carboxylic acids. High ALDH activity has been related to some important features of cancer stem cells. ALDH1A enzymes, involved in the retinoic acid signaling pathway, are promising drug targets for cancer therapy, and the design of selective ALDH1A inhibitors has a growing pharmacological interest. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.004DOI Listing
April 2019
1 Read

In vitro SOD-like activity of mono- and di-copper complexes with a phosphonate substituted SALAN-type ligand.

Chem Biol Interact 2019 Apr 4;306:78-88. Epub 2019 Apr 4.

RIKEN, SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo, 679-5148, Japan; European X-Ray Free-Electron Laser Facility GmbH, Schenefeld, 22869, Germany. Electronic address:

SALEN- and SALAN-based complexes with catalytically active metal centers are very promising small molecules to be utilized as part of antioxidant therapies. Here we discuss a modified SALAN-type molecule armed with two phosphonate groups that significantly increase its water solubility and aid to furnish mono- or dinuclear complexes with Cu ions. The regulation of the SOD-mimicking (i. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.003DOI Listing
April 2019
2.577 Impact Factor

Hesperidin inhibits synovial cell inflammation and macrophage polarization through suppression of the PI3K/AKT pathway in complete Freund's adjuvant-induced arthritis in mice.

Chem Biol Interact 2019 Apr 5;306:19-28. Epub 2019 Apr 5.

Department of Orthopedics, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510630, Guangdong, China; Orthopedic Hospital of Guangdong Province, Guangzhou, 510630, Guangdong, China. Electronic address:

Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovitis. Synovitis can cause joint injury by releasing inflammatory factors and metalloproteinases (MMPs). Therefore, it is necessary to find drugs that can control synovitis in the process of RA. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.002DOI Listing
April 2019
2 Reads

Resveratrol: Review on its discovery, anti-leukemia effects and pharmacokinetics.

Chem Biol Interact 2019 Apr 5;306:29-38. Epub 2019 Apr 5.

Center of Hematology, Key Laboratory of Tumor Immunotherapy of Chongqing, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, PR China. Electronic address:

Resveratrol, found in variety of plants, is a natural stilbene structure polyphenol. It has various pharmacological effects, such as antioxidation, anti-aging, anti-inflammation, anti-cancer, antiobesity, anti-diabetes, cardioprotection, neuroprotection. Recently, anti-leukemia activities of resveratrol has been studied extensively via its effects on a variety of biological processes involving cell proliferation, apoptosis, autophagy. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.001DOI Listing

Curcumin analogues attenuate Aβ-induced oxidative stress in PC12 cells via Keap1/Nrf2/HO-1 signaling pathways.

Chem Biol Interact 2019 Apr 1;305:171-179. Epub 2019 Apr 1.

College of Pharmaceutical Science, Zhejiang University of Technology, 18 Chaowang Road, Hangzhou, Zhejiang, 310014, PR China; Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, 18 Chaowang Road, Hangzhou, Zhejiang, 310014, PR China. Electronic address:

Beta-amyloid (Aβ) has pivotal functions in the pathogenesis of Alzheimer's Disease (AD). In the present study, we adopted an vitro model that involved Aβ-induced oxidative damage in PC12 cells. Aβ (10 μΜ) treatment for 24 h induced significant cell death and oxidative stress in PC12 cells, as evidenced by cell viability reduction, LDH release, ROS accumulation and increased production MDA. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.010DOI Listing
April 2019
1 Read

Evaluation of the promiscuous component of several bacterial export pumps TolC as a biomarker for toxic pollutants in feedstuffs.

Chem Biol Interact 2019 Mar 30;305:195-202. Epub 2019 Mar 30.

Laboratory of Experimental Hepatology and Drug Targeting (HEVEFARM), IBSAL, University of Salamanca, Salamanca, Spain; Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Institute of Health, Madrid, Spain.

A significant risk to the food chain is the presence of noxious pollutants in the feeds of animals whose products are used in human nutrition. Consequently, analytical methods and biosensors have been developed to detect these types of contaminates in feeds. Here we have evaluated whether the expression of TolC, a promiscuous component of several ATP-dependent efflux pumps in E. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.03.028DOI Listing
March 2019
3 Reads

Antigrowth activity and induction of apoptosis in human melanoma cells by Drymis winteri forst extract and its active components.

Chem Biol Interact 2019 Mar 29;305:79-85. Epub 2019 Mar 29.

Departamento de Química, Facultad de CienciasNaturales y Exactas, Universidad de PlayaAncha, Avda. Leopoldo Carvallo 270, PlayaAncha, Valparaíso, 2340000, Chile.

Melanoma is a highly invasive cancer that resists most conventional treatments. Therefore, there is an urgent need to identify alternative anticancer agents able to affect new molecular targets. Drimys winteri (Winteraceae) is a medicinal plant, employed in Brazil and many countries, in folk medicine against a variety of ailments, especially for the treatment of fevers, ulcers, pains, affections of respiratory tract and cancers. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.03.029DOI Listing
March 2019
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Effects of curcumin and its adjuvant on TPC1 thyroid cell line.

Chem Biol Interact 2019 Mar 30;305:112-118. Epub 2019 Mar 30.

Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Via F. De Santis, 86100, Campobasso, Italy. Electronic address:

Previous studies have demonstrated that different curcumin extracts are able to influence cell metabolic activity vitality in human papillary thyroid carcinoma TPC-1 cells. We continued the study using the most effective extract and adding other nutraceuticals such as piperine and vitamin E, in order to define the possible role of these in modulating the genetic expression of cell markers and to understand the effectiveness in modulating the regression of cancer phenotype. Cells were treated with one extract of curcumin (Naturex Ultimate Botanical Benefits), with Piperine (Piper Longum, A. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.03.031DOI Listing
March 2019
4 Reads

Polyhexamethylene guanidine phosphate-induced upregulation of MUC5AC via activation of the TLR-p38 MAPK and JNK axis.

Chem Biol Interact 2019 Mar 29;305:119-126. Epub 2019 Mar 29.

School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, 16419, Republic of Korea. Electronic address:

Epidemiological and toxicological studies indicate that polyhexamethylene guanidine phosphate (PHMG-p) is a guanidine-based cationic disinfectant strongly associated with interstitial lung diseases. As individuals exposed to aerosolized PHMG-p complain of respiratory problems (asthma and rhinitis), whether PHMG-p can cause respiratory diseases other than interstitial fibrosis should be investigated. MUC5AC, the predominant mucin gene expressed in airways, is associated with obstructive respiratory disease pathogenesis. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.03.030DOI Listing
March 2019
3 Reads

Guajadial reverses multidrug resistance by inhibiting ABC transporter expression and suppressing the PI3K/Akt pathway in drug-resistant breast cancer cells.

Chem Biol Interact 2019 Mar 28;305:98-104. Epub 2019 Mar 28.

Department of General Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, 121000, PR China.

Multidrug resistance remains a major challenge in the chemotherapy of breast cancer. Guajadial, a natural meroterpenoid, has been found to possess anti-tumor activity. However, the role of guajadial in drug resistance has not been investigated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797183166
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http://dx.doi.org/10.1016/j.cbi.2019.03.032DOI Listing
March 2019
3 Reads

ATDC contributes to sustaining the growth and invasion of glioma cells through regulating Wnt/β-catenin signaling.

Chem Biol Interact 2019 Mar 29;305:148-155. Epub 2019 Mar 29.

Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710061, China. Electronic address:

Accumulating evidence has documented that ataxia-telangiectasia group D complementing gene (ATDC) is aberrantly expressed in various cancers and is associated with cancer development and progression. However, little is known about the role of ATDC in glioma tumorigenesis. In this study, we aimed to explore the biological function and regulatory mechanism of ATDC in glioma. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.03.033DOI Listing
March 2019
1 Read

Didymin, a dietary citrus flavonoid exhibits anti-diabetic complications and promotes glucose uptake through the activation of PI3K/Akt signaling pathway in insulin-resistant HepG2 cells.

Chem Biol Interact 2019 Mar 27;305:180-194. Epub 2019 Mar 27.

Department of Prescriptionology, College of Korean Medicine, Kyung Hee University, 26, Kyunghee Dae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea.

Didymin is a naturally occurring orally active flavonoid glycoside (isosakuranetin 7-O-rutinoside) found in various citrus fruits, which has been previously reported to possess a wide variety of pharmacological activities including anticancer, antioxidant, antinociceptive, neuroprotective, hepatoprotective, inflammatory, and cardiovascular. However, there have not been any reports concerning its anti-diabetic potential until now. Therefore, we evaluated the anti-diabetic potential of didymin via inhibition of α-glucosidase, protein tyrosine phosphatase 1B (PTP1B), rat lens aldose reductase (RLAR), human recombinant AR (HRAR), and advanced glycation end-product (AGE) formation inhibitory assays. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.03.018DOI Listing
March 2019
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Human and murine steroid 5β-reductases (AKR1D1 and AKR1D4): insights into the role of the catalytic glutamic acid.

Chem Biol Interact 2019 Mar 28;305:163-170. Epub 2019 Mar 28.

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA; Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Electronic address:

Mammalian steroid 5β-reductases belong to the Aldo-Keto Reductase 1D sub-family and are essential for the formation of A-ring 5β-reduced steroids. Steroid 5β-reduction is required for the biosynthesis of bile-acids and the metabolism of all steroid hormones that contain a Δ-3-ketosteroid functionally to yield the 5β-reduced metabolites. In mammalian AKR1D enzymes the conserved catalytic tetrad found in all AKRs (Y55, H117, K84 and D50) has changed in that the conserved H117 is replaced with a glutamic acid (E120). Read More

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http://dx.doi.org/10.1016/j.cbi.2019.03.025DOI Listing
March 2019
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2.577 Impact Factor

KLF2 regulates eNOS uncoupling via Nrf2/HO-1 in endothelial cells under hypoxia and reoxygenation.

Chem Biol Interact 2019 Mar 27;305:105-111. Epub 2019 Mar 27.

Xidian Grp Hospital, Xi'an, 710077, China. Electronic address:

Kruppel-like factor 2 (KLF2) regulates endothelial functions by modulating endothelial nitric oxide synthase (eNOS)/nitric oxide (NO) pathway. Tetrahydrobiopterin (BH) and S-glutathionylation of eNOS play essential roles in eNOS uncoupling and activation. However, the influence of KLF2 on eNOS uncoupling and the mechanism of eNOS activation still remain unknown. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.03.010DOI Listing
March 2019
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The importance of assessing aldehyde substrate inhibition for the correct determination of kinetic parameters and mechanisms: the case of the ALDH enzymes.

Chem Biol Interact 2019 Mar 27;305:86-97. Epub 2019 Mar 27.

Departamento de Bioquímica, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico.

Substrate inhibition by the aldehyde has been observed for decades in NAD(P)-dependent aldehyde dehydrogenase (ALDH) enzymes, which follow a Bi Bi ordered steady-state kinetic mechanism. In this work, by using theoretical simulations of different possible substrate inhibition mechanisms in monosubstrate and Bi Bi ordered steady-state reactions, we explored the kind and extent of errors arising when estimating the kinetic parameters and determining the kinetic mechanisms if substrate inhibition is intentionally or unintentionally ignored. We found that, in every mechanism, fitting the initial velocity data of apparently non-inhibitory substrate concentrations to a rectangular hyperbola produces important errors, not only in the estimation of V values, which were underestimated as expected, but, surprisingly, even more in the estimation of K values, which led to overestimation of the V/K values. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.03.024DOI Listing
March 2019
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Chitosan oligosaccharides prevent doxorubicin-induced oxidative stress and cardiac apoptosis through activating p38 and JNK MAPK mediated Nrf2/ARE pathway.

Chem Biol Interact 2019 Mar 28;305:54-65. Epub 2019 Mar 28.

Experimental and Teaching Center of Medical Basis for Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China. Electronic address:

Doxorubicin (DOX) is one of the most effective chemotherapeutic drugs; however, the incidence of cardiotoxicity compromises its therapeutic index. Oxidative stress and apoptosis are believed to be involved in DOX-induced cardiotoxicity. Chitosan oligosaccharides (COS), the enzymatic hydrolysates of chitosan, have been reported to possess diverse biological activities including antioxidant and anti-apoptotic properties. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.03.027DOI Listing
March 2019
2 Reads

miR-221 promotes lens epithelial cells apoptosis through interacting with SIRT1 and E2F3.

Chem Biol Interact 2019 Mar 26;306:39-46. Epub 2019 Mar 26.

Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. Electronic address:

MicroRNAs (miRNAs) have been regarded as potential modulators in varying ocular diseases, including age-related cataract (ARC). However, the roles of miR-221 in ARC progression and its underlying mechanism remain poorly understood. In this study, human lens epithelial cell line (SRA01/04) was used to investigate the potential function of miR-221 in vitro. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.03.021DOI Listing
March 2019
2 Reads
2.577 Impact Factor

Human umbilical cord perivascular cells: A novel source of the organophosphate antidote butyrylcholinesterase.

Chem Biol Interact 2019 Mar 26;305:66-78. Epub 2019 Mar 26.

DRDC Suffield Research Centre, Casualty Management Section, Box 4000 Station Main, Medicine Hat, AB, T1A 8K6, Canada.

Human butyrylcholinesterase (BChE) is a well-characterized bioscavenger with significant potential as a prophylactic or post-exposure treatment for organophosphate poisoning. Despite substantial efforts, BChE has proven technically challenging to produce in recombinant systems. Recombinant BChE tends to be insufficiently or incorrectly glycosylated, and consequently exhibits a truncated half-life, compromised activity, or is immunogenic. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797183144
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http://dx.doi.org/10.1016/j.cbi.2019.03.022DOI Listing
March 2019
3 Reads

Biochemical and physiological properties of K channel-associated AKR6A (Kvβ) proteins.

Chem Biol Interact 2019 Mar 26;305:21-27. Epub 2019 Mar 26.

Department of Medicine, Diabetes and Obesity Center, University of Louisville, Louisville, KY, 40202, USA. Electronic address:

Voltage-gated potassium (Kv) channels play an essential role in the regulation of membrane excitability and thereby control physiological processes such as cardiac excitability, neural communication, muscle contraction, and hormone secretion. Members of the Kv1 and Kv4 families are known to associate with auxiliary intracellular Kvβ subunits, which belong to the aldo-keto reductase superfamily. Electrophysiological studies have shown that these proteins regulate the gating properties of Kv channels. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.03.023DOI Listing

Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity, different from human DHRS11.

Chem Biol Interact 2019 Mar 26;305:12-20. Epub 2019 Mar 26.

Human dehydrogenase/reductase SDR family member 11 (DHRS11) has been recently reported to be an NADP-dependent 3(17)β-hydroxysteroid dehydrogenase, and its orthologs are predicted in genomic analyses of various animals. Among them, the amino acid sequence of predicted rabbit DHRS11 shares 92% identity with that of human DHRS11 and matches peptide sequences (composed of total 87 amino acids) of rabbit heart acetohexamide reductase (RHAR) previously reported. However, the physiological role of RHAR remains unknown, because its known substrates are only acetohexamide and 1,4-naphthoquinone. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.03.026DOI Listing

Methiopropamine, a methamphetamine analogue, produces neurotoxicity via dopamine receptors.

Chem Biol Interact 2019 Mar 25;305:134-147. Epub 2019 Mar 25.

Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, 24341, Republic of Korea. Electronic address:

Methiopropamine (MPA) is structurally categorized as a thiophene ring-based methamphetamine (MA) derivative. Although abusive potential of MPA was recognized, little is known about the neurotoxic potential of MPA up to now. We investigated whether MPA induces dopaminergic neurotoxicity, and whether MPA activates a specific dopamine receptor. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.03.017DOI Listing

Antinociceptive and anti-inflammatory effects of cryptotanshinone through PI3K/Akt signaling pathway in a rat model of neuropathic pain.

Chem Biol Interact 2019 Mar 26;305:127-133. Epub 2019 Mar 26.

Department of Anesthesiology, Provincial Hospital Affiliated to Shandong University, No. 324 Jingwu Road, Jinan 250021, Shandong, China. Electronic address:

Peripheral nerve injuries often induce neuropathic pain through inflammation. Cryptotanshinone isolated from Salvia miltiorrhiza Bunge has been found to exert anti-inflammatory and analgesic activities. Thus, this study aimed to determine whether cryptotanshinone inhibits chronic constriction injury (CCI)-induced neuropathic pain in rats and its mechanism of action. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.03.016DOI Listing
March 2019
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Eosinophil peroxidase oxidizes isoniazid to form the active metabolite against M. tuberculosis, isoniazid-NAD.

Chem Biol Interact 2019 Mar 25;305:48-53. Epub 2019 Mar 25.

Faculty of Pharmacy and Pharmaceutical Sciences, Katz Group Centre for Pharmacy & Health Research, University of Alberta, Edmonton, AB, Canada. Electronic address:

The formation of isonicotinyl-nicotinamide adenine dinucleotide (INH-NAD) by the mycobacterial catalase-peroxidase enzyme, KatG, was known to be the major component of the mode of action of isoniazid (INH), an anti-tuberculosis drug. However, there are other enzymes that may catalyze this reaction. We have previously reported that neutrophil myeloperoxidase (MPO) is capable of metabolizing INH through the formation of INH-NAD adduct, which could be attributed to being a possible mode of action of INH. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.03.019DOI Listing
March 2019
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2.577 Impact Factor

Thyroid cancer overdiagnosis: Implications for understanding radiation carcinogenesis and for medical imaging.

Chem Biol Interact 2019 Mar 23;305:1-2. Epub 2019 Mar 23.

Institute of Gerontology, 67 Vyshgorodskaya str., Kiev, 04114, Ukraine.

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http://dx.doi.org/10.1016/j.cbi.2019.03.020DOI Listing
March 2019
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Editorial.

Authors:
J Mark Petrash

Chem Biol Interact 2019 Mar 18;305:11. Epub 2019 Mar 18.

Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, 80238, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2019.03.015DOI Listing
March 2019
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Inhibition of Drp1 after traumatic brain injury provides brain protection and improves behavioral performance in rats.

Chem Biol Interact 2019 May 17;304:173-185. Epub 2019 Mar 17.

Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute of Shandong University, Jinan, Shandong, PR China. Electronic address:

The imbalance between mitochondrial fusion and fission has been implicated in cerebral ischemia and several neurodegenerative diseases. However, the role of mitochondrial fission in traumatic brain injury (TBI) remains poorly understood. Mitochondrial fission is mediated by dynamin-related protein 1 (Drp1), which is highly expressed in the nervous system. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.03.013DOI Listing
May 2019
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Erythropoietin attenuates high glucose-induced oxidative stress and inhibition of osteogenic differentiation in periodontal ligament stem cell (PDLSCs).

Chem Biol Interact 2019 Mar 17;305:40-47. Epub 2019 Mar 17.

Department of Orthodontics, School of Dentistry, Shandong University, Jinan, Shandong Province, People's Republic of China. Electronic address:

Diabetes mellitus and periodontitis have long been considered to be biologically linked. Erythropoietin (EPO) has multiple biological functions, such as stimulating the proliferation and differentiation of erythroid progenitor cells and reducing glucose-induced oxidative stress via different mechanisms, acting as a direct antioxidant. The purposes of the study to examine the anti-oxidative effect of EPO on reducing high glucose-induced oxidative stress of hPDLSCs and provide a better understanding of the mechanism of these processes. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.03.007DOI Listing

Expression, purification and crystallization of the novel Xenopus tropicalis ALDH16B1, a homologue of human ALDH16A1.

Chem Biol Interact 2019 May 17;304:168-172. Epub 2019 Mar 17.

Department of Pharmacology, School of Medicine, Yale University, New Haven, CT, 06510, USA. Electronic address:

ALDH16 is a novel family of the aldehyde dehydrogenase (ALDH) superfamily with unique structural characteristics that distinguish it from the other ALDH superfamily members. In addition to structural characteristics, there is an evolutionary-related grouping within the ALDH 16 genes. The ALDH16 isozymes in frog, lower animals, and bacteria possess a critical Cys residue in their active site, which is absent from ALDH16 in mammals and fish. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.03.009DOI Listing
May 2019
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Extenuation of in utero toxic effects of MeHg in the developing neurons by Fisetin via modulating the expression of synaptic transmission and plasticity regulators in hippocampus of the rat offspring.

Chem Biol Interact 2019 Mar 16;305:3-10. Epub 2019 Mar 16.

Department of Medical Biochemistry, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, 600113, Tamil Nadu, India. Electronic address:

The neurotoxic environmental contaminant, methylmercury (MeHg), has shown to have detrimental effects on the developing brain when exposed during gestation. We have shown in our earlier studies that gestational administration of 3,3',4',7-Tetrahydroxyflavone or Fisetin reduces the toxic effects of MeHg in the developing rat brain. The current study has pivoted to study the mechanism behind the mitigating action of Fisetin against prenatal MeHg exposure induced neurotoxicity. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.03.014DOI Listing