1,361,131 results match your criteria Chemical physics letters[Journal]


Application of Electron Microscopes in Nanotoxicity Assessment.

Methods Mol Biol 2019 ;1894:247-269

Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, KY, USA.

In this chapter, we highlight the applications of electron microscopes (EMs) in nanotoxicity assessment. EMs can provide detailed information about the size and morphology of nanomaterials (NMs), their localization in cells and tissues, the nano-bio interactions, as well as the ultrastructural changes induced by NMs exposure. Here, we share with the readers how we prepare the tissue sample, and the different types of EMs used among the nanotoxicologists. Read More

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January 2019

In Vitro Approaches for Assessing the Genotoxicity of Nanomaterials.

Methods Mol Biol 2019 ;1894:83-122

Department of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany.

Genotoxicity is associated with serious health effects and includes different types of DNA lesions, gene mutations, structural chromosome aberrations involving breakage and/or rearrangements of chromosomes (referred to as clastogenicity) and numerical chromosome aberrations (referred to as aneuploidy). Assessing the potential genotoxic properties of chemicals, including nanomaterials (NMs), is a key element in regulatory safety assessment. State-of-the-art genotoxicity testing includes a battery of assays covering gene mutations, structural and numerical chromosome aberrations. Read More

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January 2019

In Vitro Methods for Assessing Nanoparticle Toxicity.

Methods Mol Biol 2019 ;1894:1-29

Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY, USA.

As a consequence of their increase in annual production and widespread distribution in the environment, nanoparticles potentially pose a significant public health risk. The sought-after catalytic activity granted by their physiochemical properties doubles as a hazard to physiological processes following exposure through inhalation, oral, transdermal, subcutaneous, and intravenous uptake. Upon uptake into the body, their size, morphology, surface charge, coating, and chemical composition augment the response of biological systems to the materials and enhance their toxicity. Read More

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January 2019

Machine Learning Approach for Predicting New Uses of Existing Drugs and Evaluation of Their Reliabilities.

Authors:
Yutaka Fukuoka

Methods Mol Biol 2019 ;1903:269-279

Kogakuin University, Tokyo, Japan.

In this chapter, a new method to evaluate the reliability of predicting new uses of existing drugs was proposed. The prediction was performed with a support vector machine (SVM) using various data. Because the reliability of prediction could not be evaluated based on the output of an SVM, which was binary, the proposed method evaluated the reliability as a product of a distance from the separating hyperplane of the SVM and a similarity between the disease targeted by the drug and a candidate disease. Read More

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January 2019

A Computational Bipartite Graph-Based Drug Repurposing Method.

Methods Mol Biol 2019 ;1903:115-127

Institute of Medical Information/Library, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China.

We present a bipartite graph-based approach to calculate drug pairwise similarity for identifying potential new indications of approved drugs. Both chemical and molecular features were used in drug similarity calculation. In this paper, we first extracted drug chemical structures and drug-target interactions. Read More

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January 2019

Methods for Discovering and Targeting Druggable Protein-Protein Interfaces and Their Application to Repurposing.

Methods Mol Biol 2019 ;1903:1-21

Department of Chemical and Biological Engineering, Koc University, Istanbul, Turkey.

Drug repurposing is a creative and resourceful approach to increase the number of therapies by exploiting available and approved drugs. However, identifying new protein targets for previously approved drugs is challenging. Although new strategies have been developed for drug repurposing, there is broad agreement that there is room for further improvements. Read More

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January 2019

Chemical compositional standards for non-lead hunting ammunition and fishing weights.

Authors:
Vernon G Thomas

Ambio 2018 Dec 13. Epub 2018 Dec 13.

Department of Integrative Biology, College of Biological Science, University of Guelph, Guelph, ON, N1G 2W1, Canada.

The chemical composition of non-lead, non-toxic, gunshot used for hunting waterfowl is regulated only in Canada and the USA. No nation regulates the composition of non-lead fishing weights, rifle bullets, and gunshot used for upland game hunting. Compositional criteria for these non-lead products are proposed here, based on established experimental toxicity protocols. Read More

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December 2018

Overview and Evaluation of Recent Methods for Statistical Inference of Gene Regulatory Networks from Time Series Data.

Methods Mol Biol 2019 ;1883:49-94

School of Mathematics and Statistics, University of Glasgow, Glasgow, UK.

A challenging problem in systems biology is the reconstruction of gene regulatory networks from postgenomic data. A variety of reverse engineering methods from machine learning and computational statistics have been proposed in the literature. However, deciding on the best method to adopt for a particular application or data set might be a confusing task. Read More

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January 2019

A Possible Prebiotic Ancestry of Porphyrin-Type Protein Cofactors.

Orig Life Evol Biosph 2018 Dec 13. Epub 2018 Dec 13.

Department of Bioinorganic Chemistry and Chemical Evolution, Institute of Chemistry, University of Hohenheim, Garbenstr. 30, 70599, Stuttgart, Germany.

In previous experiments that simulated conditions on primordial volcanic islands, we demonstrated the abiotic formation of hydrophobic porphyrins. The present study focused on the question whether such porphyrins can be metalated by prebiotically plausible metal ion sources. We used water-insoluble octaethylporphyrin (Hoep) as a model compound. Read More

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December 2018

A new thermodynamic approach for struvite product quality prediction.

Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.

Department of Chemical & Materials Engineering, University of Auckland, 2-6 Park Avenue - Bldg 529, Grafton, Auckland, 1023, New Zealand.

Struvite precipitation has drawn much attention in the last decade as a green chemical process for phosphorus removal and recovery. Product purity affects the usefulness, and thus price, of the product when recovered struvite is sold as fertilizer. However, there is currently little research on struvite quality, as well as on models for accurately predicting. Read More

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December 2018

Anaerobic treatment of residuals from tanks transporting food and fodder.

Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.

Faculty of Agricultural and Environmental Sciences, University of Rostock, Justus-von-Liebig-Weg 6, 18059, Rostock, Germany.

The anaerobic digestion of wastewater from the cleaning of tank cars transporting food and fodder was investigated in both bench and pilot scales with a single-stage, mesophilic (39 °C), completely mixed process. The promising results lead to the planning and building of a 1200-m full-scale biogas plant at TS-Clean cleaning station in Fahrbinde, Germany. Due to softened water used in the cleaning of the car tanks, the alkalinity in the digester decreased as predicted by the physicochemical model developed for this treatment process. Read More

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December 2018
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Evaluation of the potential of coal fly ash produced by gasification as hexavalent chromium adsorbent.

Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.

Chemical Engineering, Federal University of Pampa, 1650 Maria Anunciação Gomes Godoy Avenue, Bagé, Rio Grande do Sul, 96413-172, Brazil.

The aim of this work was to characterize the coal fly ash from gasification process (G-CFA) and to analyze its potential as hexavalent chromium Cr (VI) adsorbent. The G-CFA was characterized in terms of physical, chemical, mineralogical, and morphological analyses. Bach adsorption studies were carried out in order to evaluate the influence of pH on the adsorption capacity and removal efficiency of Cr (VI). Read More

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December 2018

Levels of heavy metals in a multifloral Saudi honey.

Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.

Department of Plant Protection, College of Food and Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh, 11451, Saudi Arabia.

The presence of chemical pollutants, especially heavy metals, affects the quality of honey. The objective of this study was to determine the levels of eight heavy metals (As, Cd, Co, Cr, Cu, Ni, Pb, and Zn) in honey samples from Al-Baha region in Saudi Arabia, using inductively coupled plasma with optical emission spectroscopy (ICP-OES). The highest concentration was found for Zn (1707. Read More

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December 2018
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Chemical transformation mediated CRISPR/Cas9 genome editing in Escherichia coli.

Biotechnol Lett 2018 Dec 13. Epub 2018 Dec 13.

College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, Zhejiang, People's Republic of China.

Objectives: To develop a convenient chemical transformation mediated CRISPR/Cas9 (CT-CRISPR/Cas9) system for genome editing in Escherichia coli.

Results: Here, we have constructed a CT-CRISPR/Cas9 system, which can precisely edit bacterial genome (replacing, deleting, inserting or point mutating a target gene) through chemical transformation. Compared with the traditional electroporation mediated CRISPR/Cas9 (ET-CRISPR/Cas9) system, genome editing with the CT-CRISPR/Cas9 system is much cheaper and simpler. Read More

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December 2018

A thermostable trypsin from freshwater fish Japanese dace (Tribolodon hakonensis): a comparison of the primary structures among fish trypsins.

Fish Physiol Biochem 2018 Dec 13. Epub 2018 Dec 13.

Laboratory of Marine Chemical Resource Development, Faculty of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido, 041-8611, Japan.

Trypsin from Japanese dace (Tribolodon hakonensis) (JD-T) living in freshwater (2-18 °C) was purified. JD-T represented typical fish trypsin characteristics regarding the effects of protease inhibitor, calcium-ion, and pH. For the effect of temperature, JD-T quite resembled to the trypsins from tropical-zone marine fish and freshwater fish (the catfish cultured in Thailand), i. Read More

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December 2018

The Influence of a Xanthine-Catechin Chemical Matrix on in vitro Macrophage-Activation Triggered by Antipsychotic Ziprasidone.

Inflammation 2018 Dec 14. Epub 2018 Dec 14.

Postgraduate Program of Pharmacology, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil.

Ziprasidone (ZIP) is an effective antipsychotic with low side effects than other second-generation antipsychotics. Despite this, there are reports of adverse events and previous studies associating the use of ZIP the inflammatory response. It is possible to infer that bioactive molecules present in some foods could attenuate peripheral inflammatory and oxidative stress potentially triggered ZIP. Read More

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December 2018

Cardiovascular mortality attributable to dietary risk factors in 51 countries in the WHO European Region from 1990 to 2016: a systematic analysis of the Global Burden of Disease Study.

Eur J Epidemiol 2018 Dec 14. Epub 2018 Dec 14.

Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD), Halle-Jena-Leipzig, Germany.

This study was performed to highlight the relationship between single dietary risk factors and cardiovascular diseases (CVDs) in the WHO European Region. We used the comparative risk assessment framework of the Global Burden of Disease Study to estimate CVD mortality attributable to diet; comprising eleven forms of CVDs, twelve food and nutrient groups and 27 risk-outcome pairs in four GBD regions including 51 countries by age and sex between 1990 and 2016. In 2016, dietary risks were associated with 2. Read More

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December 2018
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Leaf litter species identity influences biochemical composition of ectomycorrhizal fungi.

Mycorrhiza 2018 Dec 13. Epub 2018 Dec 13.

Forest Botany and Tree Physiology, University of Goettingen, Buesgenweg 2, 37077, Goettingen, Germany.

In forest ecosystems, ectomycorrhizal (ECM) fungi are important for plant growth and soil biogeochemical processes. The biochemical composition of ECM mycelium is an important fungal effect trait with consequences for its decomposition rate, and consequently on soil carbon pools and plant nutrition. Although the link between ECM fungi and leaf litter-released nutrients is well known, the response of ECM fungal biochemical composition to different leaf litter species remains poorly understood. Read More

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December 2018

Extremely thermoactive archaeal endoglucanase from a shallow marine hydrothermal vent from Vulcano Island.

Appl Microbiol Biotechnol 2018 Dec 13. Epub 2018 Dec 13.

Institute of Technical Microbiology, University of Technology, Hamburg, Germany.

Already-characterized microbial cellulases have proven to be highly useful for industrial processes, since they can withstand harsh industrial conditions with characteristics such as high thermo- and acid stability. These properties provide promising features for the process of plant biomass degradation and biofuel generation. Nevertheless, the number of known extremely thermoactive archaeal cellulases is low. Read More

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December 2018

Hepatic steatosis and reduction in steatosis following bariatric weight loss surgery differs between segments and lobes.

Eur Radiol 2018 Dec 13. Epub 2018 Dec 13.

Liver Imaging Group, Department of Radiology, University of California San Diego, 200 W. Arbor Drive #8756, San Diego, CA, 92103-8756, USA.

Objectives: The purpose of this study was to (1) evaluate proton density fat fraction (PDFF) distribution across liver segments at baseline and (2) compare longitudinal segmental PDFF changes across time points in adult patients undergoing a very low-calorie diet (VLCD) and subsequent bariatric weight loss surgery (WLS).

Methods: We performed a secondary analysis of data from 118 morbidly obese adult patients enrolled in a VLCD-WLS program. PDFF was estimated using magnitude-based confounder-corrected chemical-shift-encoded (CSE) MRI in each hepatic segment and lobe at baseline (visit 1), after completion of VLCD (visit 2), and at 1, 3, and 6 months (visits 3-5) following WLS. Read More

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December 2018

Pumpless platform for high-throughput dynamic multicellular culture and chemosensitivity evaluation.

Lab Chip 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemical Engineering and Materials Science, Stevens Institute of Technology, 1 Castle Point on Hudson, Hoboken, New Jersey 07030, USA.

We report here a novel pumpless, 96-well plate-based platform for high-throughput dynamic multicellular culture and chemosensitivity evaluation. A gravity-driven flow strategy was developed to generate and sustain the flow rate of culture medium within 10% in the platform's 20 culture chambers. The ability of the platform to generate and sustain the medium flow was demonstrated by computational simulation, flow visualization, and ascertaining the previously known effect of flow-induced shear stress on the stimulated osteogenic differentiation of osteoblasts. Read More

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December 2018

Fabrication of composite microfluidic devices for local control of oxygen tension in cell cultures.

Lab Chip 2018 Dec 14. Epub 2018 Dec 14.

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.

Oxygen tension is a central component of the cellular microenvironment and can serve as a trigger for changes in cell phenotype and function. There is a strong need to precisely control and modulate oxygen tension in cell culture systems in order to more accurately model the physiology and pathophysiology observed in vivo. The objective of this paper was to develop a simple, yet effective strategy for local control of oxygen tension in microfluidic cell cultures. Read More

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December 2018

Development of a microdevice for facile analysis of theophylline in whole blood by a cloned enzyme donor immunoassay.

Lab Chip 2018 Dec 14. Epub 2018 Dec 14.

Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan and ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan and Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu 761-0395, Japan.

We have developed a microdevice for therapeutic drug monitoring. In this device, dispensing of sample and reagent was accomplished by simple manual operation of a syringe. Moreover, for a simple and rapid measurement, we used cloned enzyme donor immunoassay as a detection principle. Read More

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December 2018

Efficient hydrogen evolution on (CuInS)(ZnS) solid solution-based photocathodes under simulated sunlight.

Chem Commun (Camb) 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemical System Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. and Center for Energy & Environmental Science, Shinshu University, 4-17-1 Wakasato, Nagano-shi, Nagano 380-8553, Japan.

A thin film of (CuInS2)x(ZnS)1-x has been developed as a photocathode for solar water splitting for the first time. A superior photoelectrochemical performance has been achieved, mainly attributed to the formation of a solid solution by CuInS2 and ZnS, which proved to be an effective strategy to improve the onset potential and efficiency of CuInS2 photocathodes. Read More

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December 2018

Rhodium(iii)-catalyzed aromatic C-H cyanation with dimethylmalononitrile as a cyanating agent.

Chem Commun (Camb) 2018 Dec 14. Epub 2018 Dec 14.

State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China. and School of Petroleum and Chemical Engineering, Dalian University of Technology, Panjin 124221, China.

A rhodium-catalyzed aromatic C-H bond direct cyanation with safe, bench-stable, and commercially available dimethylmalononitrile as the cyanating agent has been successfully developed by using copper oxide as a promotor. Pyridine, quinoline, pyrimidine and pyrazole were used as the directing group in this type of C-H bond direct cyanation reaction. Read More

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December 2018

Elucidating cation-cation interactions in neptunyl dications using multi-reference ab initio theory.

Phys Chem Chem Phys 2018 Dec 14. Epub 2018 Dec 14.

Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Toruń, Grudziądzka 5, 87-100 Toruń, Poland.

Understanding the binding mechanism in neptunyl clusters formed due to cation-cation interactions is of crucial importance in nuclear waste reprocessing and related areas of research. Since experimental manipulations with such species are often rather limited, we have to rely on quantum-chemical predictions of their electronic structures and spectroscopic parameters. In this work, we present a state-of-the-art quantum chemical study of the T-shaped and diamond-shaped neptunyl(v) and neptunyl(vi) dimers. Read More

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December 2018

Palladium-catalyzed trisallylation of benzoxazoles and 2-aryl-1,3,4-oxadiazoles with alkyne.

Chem Commun (Camb) 2018 Dec 14. Epub 2018 Dec 14.

Institut für Organische Chemie, Freiburg Institute for Advanced Studies (FRIAS), Albert-Ludwigs-Universität Freiburg, Albertstrasse 21, 79104 Freiburgim Breisgau, Germany.

A Pd-catalyzed direct C-H trisallylation of azoles with alkyne has been described. A consecutive C(sp2)-H allylation/olefin isomerization/double C(sp3)-H allylation of azoles and alkyne via a palladium catalysis system proceeds efficiently to afford the corresponding C2-alkenylated azoles containing an all quaternary carbon center. Read More

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December 2018

Strong metal-support interactions of Co-based catalysts facilitated by dopamine for highly efficient ammonia synthesis: in situ XPS and XAFS spectroscopy coupled with TPD studies.

Chem Commun (Camb) 2018 Dec 14. Epub 2018 Dec 14.

National Engineering Research Center of Chemical Fertilizer Catalyst, Fuzhou University, Fuzhou, Fujian 350002, China.

We report a new strategy for strengthening metal-support interaction and stabilizing Co nanoparticles at high temperature. Through the use of dopamine and removal of carbon layers by thermal N2 treatment, ceria-based Co catalysts that are efficient and highly stable for ammonia synthesis can be obtained. The ammonia synthesis rate at 425 °C and 1 MPa is enhanced from 3. Read More

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December 2018
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A pentadentate member of the picolinate family for Mn(ii) complexation and an amphiphilic derivative.

Dalton Trans 2018 Dec 14. Epub 2018 Dec 14.

Universidade da Coruña, Centro de Investigacións Científicas Avanzadas (CICA) and Departamento de Química, Facultade de Ciencias, 15071, A Coruña, Galicia, Spain.

We report a pentadentate ligand containing a 2,2'-azanediyldiacetic acid moiety functionalized with a picolinate group at the nitrogen atom (H3paada), as well as a lipophylic derivative functionalized with a dodecyloxy group at position 4 of the pyridyl ring (H3C12Opaada). The protonation constants of the paada3- ligand and the stability constant of the Mn(ii) complex were determined using a combination of potentiometric and spectrophotometric titrations (25 °C, 0.15 M NaCl). Read More

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December 2018

Multicomponent new particle formation from sulfuric acid, ammonia, and biogenic vapors.

Sci Adv 2018 Dec 12;4(12):eaau5363. Epub 2018 Dec 12.

Institute for Atmospheric and Earth System Research/Physics, Faculty of Science, University of Helsinki, P.O. Box 64, FI-00014 Helsinki, Finland.

A major fraction of atmospheric aerosol particles, which affect both air quality and climate, form from gaseous precursors in the atmosphere. Highly oxygenated organic molecules (HOMs), formed by oxidation of biogenic volatile organic compounds, are known to participate in particle formation and growth. However, it is not well understood how they interact with atmospheric pollutants, such as nitrogen oxides (NO ) and sulfur oxides (SO ) from fossil fuel combustion, as well as ammonia (NH) from livestock and fertilizers. Read More

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December 2018

Drug-Drug Interaction Discovery: Kernel Learning from Heterogeneous Similarities.

Smart Health (Amst) 2018 Dec 7;9-10:88-100. Epub 2018 Jul 7.

Erik Jonsson School of Engineering and Computer Science, The University of Texas at Dallas, United States.

We develop a pipeline to mine complex drug interactions by combining different similarities and interaction types (molecular, structural, phenotypic, genomic etc). Our goal is to learn an optimal kernel from these heterogeneous similarities in a supervised manner. We formulate an extensible framework that can easily integrate new interaction types into a rich model. Read More

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December 2018

Cartilage Tissue Engineering Using Stem Cells and Bioprinting Technology-Barriers to Clinical Translation.

Front Surg 2018 27;5:70. Epub 2018 Nov 27.

Department of Surgery, University of Melbourne, Melbourne, VIC, Australia.

There is no long-term treatment strategy for young and active patients with cartilage defects. Early and effective joint preserving treatments in these patients are crucial in preventing the development of osteoarthritis. Tissue engineering over the past few decades has presented hope in overcoming the issues involved with current treatment strategies. Read More

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November 2018

Perfluorophenyl Derivatives as Unsymmetrical Linkers for Solid Phase Conjugation.

Front Chem 2018 28;6:589. Epub 2018 Nov 28.

School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa.

Linkers play major roles in conjugation chemistry toward the advancement of drug discovery. Two different series of fluorinated linkers were introduced to the backbone of a model peptide using solid phase peptide synthesis. These fluorinated linkers have the potential to conjugate two asymmetrical groups. Read More

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November 2018

A Dual Mode Propulsion System for Small Satellite Applications.

Aerospace (Basel) 2018 2;5(2):52. Epub 2018 May 2.

Department of Mechanical Engineering, University of Vermont, Burlington, VT 05405, USA;

This study focused on the development of a chemical micropropulsion system suitable for primary propulsion and/or attitude control for a nanosatellite. Due to the limitations and expense of current micropropulsion technologies, few nanosatellites with propulsion have been launched to date; however, the availability of such a propulsion system would allow for new nanosatellite mission concepts, such as deep space exploration, maneuvering in low gravity environments and formation flying. This work describes the design of "dual mode" monopropellant/bipropellant microthruster prototype that employs a novel homogeneous catalysis scheme. Read More

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The author identified by his method: EuPA YPIC challenge solved.

EuPA Open Proteom 2018 Dec 13;20:1-8. Epub 2018 Oct 13.

Moscow Institute of Physics and Technology (State University), Moscow, Russia.

Here we present the results of our attempt on the EuPA YPIC challenge. The task was to sequence the provided synthetic peptides, build the sentence encrypted in them and determine from which book the sentence originated. The task itself, while holding no direct scientific value, offers an insight in less formal terms (for participants at least) on how the overall process of a scientific study of a "new protein" looks like. Read More

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December 2018

Investigation of CVD graphene as-grown on Cu foil using simultaneous scanning tunneling/atomic force microscopy.

Beilstein J Nanotechnol 2018 28;9:2953-2959. Epub 2018 Nov 28.

Department of Physics Engineering, İstanbul Technical University, 34469, İstanbul, Turkey.

Scanning tunneling microscopy (STM) and atomic force microscopy (AFM) images of graphene reveal either a triangular or honeycomb pattern at the atomic scale depending on the imaging parameters. The triangular patterns at the atomic scale are particularly difficult to interpret, as the maxima in the images could be every other carbon atom in the six-fold hexagonal array or even a hollow site. Carbon sites exhibit an inequivalent electronic structure in HOPG or multilayer graphene due to the presence of a carbon atom or a hollow site underneath. Read More

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November 2018

Ternary nanocomposites of reduced graphene oxide, polyaniline and hexaniobate: hierarchical architecture and high polaron formation.

Beilstein J Nanotechnol 2018 26;9:2936-2946. Epub 2018 Nov 26.

School of Materials and National Graphene Institute, The University of Manchester, Booth St E, Manchester M13 9PL, United Kingdom.

Nanostructured systems, such as nanocomposites, are potential materials for usage in different fields since synergistic effects of their components at the nanoscale domain may improve physical/chemical properties when compared to individual phases. We report here the preparation and characterisation of a new nanocomposite composed of polyaniline (PANI), reduced graphene oxide (rGO) and hexaniobate (hexNb) nanoscrolls. Atomic force microscopy images show an interesting architecture of rGO flakes coated with PANI and decorated by hexNb. Read More

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November 2018

In situ characterization of nanoscale contaminations adsorbed in air using atomic force microscopy.

Beilstein J Nanotechnol 2018 23;9:2925-2935. Epub 2018 Nov 23.

Centro de Investigación en Óptica y Nanofísica (CIOyN), Departamento Física, Facultad de Química, Campus Espinardo, Universidad de Murcia, 30100 Murcia, Spain.

Under ambient conditions, surfaces are rapidly modified and contaminated by absorbance of molecules and a variety of nanoparticles that drastically change their chemical and physical properties. The atomic force microscope tip-sample system can be considered a model system for investigating a variety of nanoscale phenomena. In the present work we use atomic force microscopy to directly image nanoscale contamination on surfaces, and to characterize this contamination by using multidimensional spectroscopy techniques. Read More

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November 2018

Layered calcium phenylphosphonate: a hybrid material for a new generation of nanofillers.

Beilstein J Nanotechnol 2018 20;9:2906-2915. Epub 2018 Nov 20.

SYNPO, akciová společnost, S. K. Neumanna 1316, 532 07 Pardubice, Czech Republic.

The use of nanosheets of layered calcium phenylphosphonate as a filler in a polymeric matrix was investigated. Layered calcium phenylphosphonate (CaPhP), with chemical formula CaCHPO∙2HO, is a hybrid organic-inorganic material that exhibits a hydrophobic character due to the presence of phenyl groups on the surface of the layers. In this paper, various CaPhP synthesis methods were studied with the aim of obtaining a product most suitable for its subsequent exfoliation. Read More

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November 2018
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Optimal Scene Time to Achieve Favorable Outcomes in Out-of-hospital Cardiac Arrest: How Long Is Too Long?

Cureus 2018 Oct 9;10(10):e3434. Epub 2018 Oct 9.

Internal Medicine, Brookdale University Hospital Medical Center, New York, USA.

Background Despite advances in resuscitation science and public health, out-of-hospital cardiac arrest (OOHCA) cases have an average survival rate of only 12% nationwide, compared to 24.8% of cases occurring in hospital. Many factors, including resuscitation interventions, contribute to positive patient outcomes and have, therefore, been studied in attempts to optimize emergency medical services (EMS) protocols to achieve higher rates of return of spontaneous circulation (ROSC) in the field. Read More

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October 2018

Ultrathin-Film Titania Photocatalyst on Nanocavity for CO Reduction with Boosted Catalytic Efficiencies.

Global Chall 2018 Nov 19;2(11):1800032. Epub 2018 Sep 19.

Department of Chemical and Biomolecular Engineering University of Maryland College Park MD 20742 USA.

Photocatalytic CO reduction with water to hydrocarbons represents a viable and sustainable process toward greenhouse gas reduction and fuel/chemical production. Development of more efficient catalysts is the key to mitigate the limits in photocatalytic processes. Here, a novel ultrathin-film photocatalytic light absorber (UFPLA) with TiO films to design efficient photocatalytic CO conversion processes is created. Read More

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November 2018

Calcium release and physical properties of modified carbonate apatite cement as pulp capping agent in dental application.

Biomater Res 2018 6;22:35. Epub 2018 Dec 6.

3Department of Mechanical Engineering and Engineering Science, The University of North Carolina at Charlotte, Charlotte, NC USA.

Background: Carbonate apatite (COAp) and silica-calcium phosphate composite (SCPC) are bone substitutes with good prospect for dental application. SCPC creates a hydroxyapatite surface layer and stimulate bone cell function while, COAp induce apatite crystal formation with good adaptation providing good seal between cement and the bone. Together, these materials will add favorable properties as a pulp capping material to stimulate mineral barrier and maintain pulp vitality. Read More

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December 2018
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YaTCM: Yet another Traditional Chinese Medicine Database for Drug Discovery.

Comput Struct Biotechnol J 2018 23;16:600-610. Epub 2018 Nov 23.

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin 300353, China.

Traditional Chinese Medicine (TCM) has a long history of widespread clinical applications, especially in East Asia, and is becoming frequently used in Western countries. However, owing to extreme complicacy in both chemical ingredients and mechanism of action, a deep understanding of TCM is still difficult. To accelerate the modernization and popularization of TCM, a single comprehensive database is required, containing a wealth of TCM-related information and equipped with complete analytical tools. Read More

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November 2018

Molecular Mechanisms of Bacterial Bioluminescence.

Comput Struct Biotechnol J 2018 15;16:551-564. Epub 2018 Nov 15.

Institute of Biochemistry, Graz University of Technology, Graz, Austria.

Bioluminescence refers to the production of light by living organisms. Bioluminescent bacteria with a variety of bioluminescence emission characteristics have been identified in , and . Bioluminescent bacteria are mainly found in marine habitats and they are either free-floating, sessile or have specialized to live in symbiosis with other marine organisms. Read More

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November 2018

Transaminase-Catalyzed Racemization with Potential for Dynamic Kinetic Resolutions.

ChemCatChem 2018 Nov 11;10(21):5012-5018. Epub 2018 Oct 11.

Department of Industrial Biotechnology KTH Royal Institute of Technology AlbaNova University Center Stockholm SE-106 91 Sweden.

Dynamic kinetic resolution (DKR) reactions in which a stereoselective enzyme and a racemization step are coupled in one pot would represent powerful tools for the production of enantiopure amines through enantioconvergence of racemates. The exploitation of DKR strategies is currently hampered by the lack of effective, enzyme-compatible and scalable racemization strategies for amines. In the present work, the proof of concept of a fully biocatalytic method for amine racemization is presented. Read More

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November 2018
1 Read

Chitosan-based nanoparticles with damnacanthal suppress CRM1 expression.

Oncol Lett 2018 Dec 26;16(6):7029-7034. Epub 2018 Sep 26.

Department of Veterinary Medicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of Korea.

Cancer is one of the leading causes of mortality worldwide. Phytochemicals may be promising anticancer agents given their various chemical structures and diverse biological activities. Damnacanthal (DAM) is a major bioactive component of Noni, which has been investigated previously as a cancer-preventive or chemotherapeutic agent. Read More

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December 2018
2 Reads

Quantum dot-based fluorescent probes for targeted imaging of the EJ human bladder urothelial cancer cell line.

Exp Ther Med 2018 Dec 28;16(6):4779-4783. Epub 2018 Sep 28.

Department of Urology, Robert Debré Teaching Hospital, University of Reims, 51100 Reims, France.

QDs are a type of inorganic nanoparticle with unique optical properties. As a fluorescent label, QDs are widely used in biomedical fields. In the present study, fluorescent probes of quantum dots (QDs) conjugated with a prostate stem cell antigen (PSCA) monoclonal antibody (QD-PSCA) were prepared to study the targeted imaging of QD-PSCA probes in EJ human bladder urothelial cancer cells and analyze the feasibility of QD-based non-invasive tumor-targeted imaging . Read More

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December 2018

Anaerobic Degradation of the Plant Sugar Sulfoquinovose Concomitant With HS Production: K-12 and sp. Strain DF1 as Co-culture Model.

Front Microbiol 2018 27;9:2792. Epub 2018 Nov 27.

Department of Biology, University of Konstanz, Konstanz, Germany.

Sulfoquinovose (SQ, 6-deoxy-6-sulfoglucose) is produced by plants and other phototrophs and its biodegradation is a relevant component of the biogeochemical carbon and sulfur cycles. SQ is known to be degraded by aerobic bacterial consortia in two tiers via C-organosulfonates as transient intermediates to CO, water and sulfate. In this study, we present a first laboratory model for anaerobic degradation of SQ by bacterial consortia in two tiers to acetate and hydrogen sulfide (HS). Read More

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November 2018

Digenic Inheritance of Shortened Repeat Units of the D4Z4 Region and a Loss-of-Function Variant in in a Family With FSHD.

Front Neurol 2018 28;9:1027. Epub 2018 Nov 28.

Molecular Genetics Laboratory UILDM, Santa Lucia Foundation, Rome, Italy.

Facioscapulohumeral muscular dystrophy (FSHD) is a neuromuscular disorder which is typically transmitted by an autosomal dominant pattern, although reduced penetrance and sporadic cases caused by mutations, are often observed. FSHD may be caused by a contraction of a repetitive element, located on chromosome 4 (4q35). This locus is named and consists of 11 to more than 100 repeated units (RU). Read More

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November 2018

Downregulation of Neuronal and Dendritic Connexin36-Made Electrical Synapses Without Glutamatergic Axon Terminals in Spinal Anterior Horn Cells From the Early Stage of Amyotrophic Lateral Sclerosis.

Front Neurosci 2018 28;12:894. Epub 2018 Nov 28.

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Connexin36 (Cx36) forms gap junctions between neurons, which are called electrical synapses, enabling adjacent neurons to communicate directly. The participation of chemical synapses in neurodegeneration in amyotrophic lateral sclerosis (ALS) has long been indicated, but it remains unclear whether electrical synapses are involved in the pathogenesis of ALS. We performed extensive immunopathological analyses using mutant superoxide dismutase 1 (SOD1) transgenic mice and their littermates to investigate whether Cx36-made electrical synapses are affected in motor neuron diseases. Read More

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November 2018
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