1,377,779 results match your criteria Chemical communications Cambridge England[Journal]


The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel.

Pharmacol Res 2019 Feb 19. Epub 2019 Feb 19.

Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy. Electronic address:

Ibuprofen is a widely used non-steroidal anti-inflammatory drug (NSAID) that exerts analgesic and anti-inflammatory actions. The transient receptor potential ankyrin 1 (TRPA1) channel, expressed primarily in nociceptors, mediates the action of proalgesic and inflammatory agents. Ibuprofen metabolism yields the reactive compound, ibuprofen-acyl glucuronide, which, like other TRPA1 ligands, covalently interacts with macromolecules. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.02.019DOI Listing
February 2019

Possible clues for camptothecin biosynthesis from the metabolites in camptothecin-producing plants.

Fitoterapia 2019 Feb 19. Epub 2019 Feb 19.

Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China. Electronic address:

The plant derived camptothecin (CPT) is a pentacyclic pyrroloquinoline alkaloid with unique antitumor activity. Successive discoveries of new CPT-producing plants occurred in recent years due to market demands. The scattered distribution among angiosperms drew researchers' attention. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.02.014DOI Listing
February 2019

Bis-iridoid and iridoid glycosides: Viral protein R inhibitors from Picrorhiza kurroa collected in Myanmar.

Fitoterapia 2019 Feb 19. Epub 2019 Feb 19.

Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan. Electronic address:

Four new bis-iridoid glycosides, saungmaygaosides A-D (1-4), and six known iridoid glycosides (5-10) were isolated from the n-butanol extract of the stems of Picrorhiza kurroa collected in Myanmar. Their structures were elucidated by extensive spectroscopic techniques. All of the isolates were assayed for anti-Vpr activity, using TREx-HeLa-Vpr cells. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.02.016DOI Listing
February 2019

Silencing of ionotropic receptor 25a decreases chemosensory activity in the salmon louse Lepeophtheirus salmonis during the infective stage.

Gene 2019 Feb 19. Epub 2019 Feb 19.

Institute of Marine Research, Austevoll Research Station, Saugeneset 16, 5392 Storebø, Norway. Electronic address:

Chemoreception is critical for marine ectoparasites - such as salmon lice (Lepeophtheirus salmonis) - to identify and locate salmonid hosts. The molecular receptors that parasites employ to detect host-specific chemical stimuli from hosts (kairomones) have not been well characterised. In the present study, transcription of the sea louse Ionotropic receptor 25a (IR25a) was blocked to evaluate whether it functions as a chemical-perception related gene for a specific chemical cue from the Atlantic salmon host. Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.012DOI Listing
February 2019

FAM134B promotes esophageal squamous cell carcinoma in vitro and its correlations with clinicopathologic features.

Hum Pathol 2019 Feb 19. Epub 2019 Feb 19.

Department of Cancer Molecular Pathology, School of Medicine, Griffith University, Gold Coast, Australia. Electronic address:

Family with sequence similarity 134, member B (FAM134B) is an autophagy regulator of endoplasmic reticulum first discovered to be involved in the pathogenesis of esophageal squamous cell carcinoma (ESCC). The present study examined the functional behavior of FAM134B in cancer cells and the association of FAM134B expression with clinicopathologic factors in patients with ESCC. Expression at both the mRNA and protein levels was investigated using real-time polymerase chain reaction and immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.033DOI Listing
February 2019

Triclosan-loaded chitosan as antibacterial agent for adhesive resin.

J Dent 2019 Feb 19. Epub 2019 Feb 19.

Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2492, Rio Branco, 90035-003, Porto Alegre, RS, Brazil. Electronic address:

Objectives: The aim of this study was to formulate and to evaluate the immediate and long-term physical, chemical and antibacterial properties of an experimental adhesive resin with chitosan or triclosan-loaded chitosan.

Materials And Methods: Chitosan, triclosan and triclosan-loaded chitosan were evaluated for scanning electron microscopy (SEM) and micro-Raman spectroscopy. An experimental adhesive resin was formulated with methacrylate monomers and photoinitiators. Read More

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http://dx.doi.org/10.1016/j.jdent.2019.02.002DOI Listing
February 2019

A case study on the application of an expert-driven read-across approach in support of quantitative risk assessment of p,p'-dichlorodiphenyldichloroethane.

Regul Toxicol Pharmacol 2019 Feb 19. Epub 2019 Feb 19.

National Center for Environmental Assessment (NCEA), U.S. Environmental Protection Agency, Cincinnati, OH, 45268, USA.

Deriving human health risk estimates for environmental chemicals has traditionally relied on in vivo toxicity databases to characterize potential adverse health effects and associated dose-response relationships. In the absence of in vivo toxicity information, new approach methods (NAMs) such as read-across have the potential to fill the required data gaps. This case study applied an expert-driven read-across approach to identify and evaluate analogues to fill non-cancer oral toxicity data gaps for p,p'-dichlorodiphenyldichloroethane (p,p'-DDD), an organochlorine contaminant known to occur at contaminated sites in the U. Read More

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http://dx.doi.org/10.1016/j.yrtph.2019.02.010DOI Listing
February 2019

Reductively cleavable polymer-drug conjugates based on dendritic polyglycerol sulfate and monomethyl auristatin E as anticancer drugs.

J Control Release 2019 Feb 19. Epub 2019 Feb 19.

Institute for Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, Berlin 14195, Germany. Electronic address:

Stimuli-responsive polymer-drug conjugates (PDCs) provide promising approaches in anticancer treatment. Here, we report the synthesis and biological evaluation of PDCs made of the highly potent antimitotic agent monomethyl auristatin E conjugated to dendritic polyglycerol and dendritic polyglycerol sulfate via a reductively cleavable, self-immolative disulfide linker. Cell viability assays with the human cancer cell lines A549 (lung carcinoma) and HeLa (cervix carcinoma) revealed that the drug's cytotoxicity was reduced by conjugation to the polymers, with the sulfated conjugates being more effective than the non-sulfated ones. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.01.035DOI Listing
February 2019

Discovery of a First-In-Class Covalent Allosteric Inhibitor of SUMO E1 Activating Enzyme.

Cell Chem Biol 2019 Feb;26(2):153-155

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

SUMOylation is a post-translational modification with important roles in normal physiology and whose dysregulation is associated with human diseases. In this issue of Cell Chemical Biology, Li et al. (2019) describe a covalent, allosteric inhibitor of the SUMO E1 enzyme and demonstrate its anti-tumor activity in preclinical models of colorectal cancer. Read More

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http://dx.doi.org/10.1016/j.chembiol.2019.02.006DOI Listing
February 2019

Chemistry Helps to Bump Off-Target Edits Away.

Cell Chem Biol 2019 Feb;26(2):151-152

Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany. Electronic address:

Side-directed RNA editing is an emerging tool to manipulate genetic information. Unfortunately, most approaches suffer from off-target editing. In this issue of Cell Chemical Biology, Monteleone et al. Read More

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http://dx.doi.org/10.1016/j.chembiol.2019.02.005DOI Listing
February 2019

Oxidative and Toxicological Evolution of Engineered Nanoparticles with Atmospherically Relevant Coatings.

Environ Sci Technol 2019 Feb 22. Epub 2019 Feb 22.

The health impacts associated with engineered nanoparticles (ENPs) released into the atmosphere have not been adequately assessed. Such impacts could potentially arise from the toxicity associated with condensable atmospheric secondary organic material (SOM), or changes in the SOM composition induced by ENPs. Here, these possibilities are evaluated by investigating the oxidative and toxicological evolution of TiO2 and SiO2 nanoparticles which have been coated with SOM from the O3 or . Read More

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http://dx.doi.org/10.1021/acs.est.8b06879DOI Listing
February 2019

Experimental Investigation on Vertically-Oriented Graphene Grown in a Plasma Enhanced Chemical Vapor Deposition Process.

ACS Appl Mater Interfaces 2019 Feb 22. Epub 2019 Feb 22.

Vertically-oriented graphene with 3D architectures has been proved to exhibit unique properties and their particular morphology has been realized by researchers to be crucial for their performances in practical applications. In this study, we investigated the morphology evolution of VG films synthesized by the plasma enhanced chemical vapor deposition (PECVD) process, including porous graphene film, graphene wall, and graphene forest. This study reveals that the morphology of VG is controlled by a combination of the deposition and etching effects and tailored by the growth conditions, such as plasma source power, growth time and temperature. Read More

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http://dx.doi.org/10.1021/acsami.9b00896DOI Listing
February 2019

Installation of Trimethyllysine Analogs on Intact Histones via Cysteine Alkylation.

Bioconjug Chem 2019 Feb 22. Epub 2019 Feb 22.

Site-specific incorporation of posttranslationally-modified amino acids into proteins, including histones, has been a subject of great interest for chemical and biochemical communities. Here, we describe a site-specific incorporation of structurally simplest trimethyllysine analogs into the position 4 of the intact histone H3 protein. An efficient alkylation of cysteine 4 of the recombinantly expressed histone H3 provides a panel of trimethyllysine analogs that differ in charge, charge density, sterics and chain length. Read More

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http://dx.doi.org/10.1021/acs.bioconjchem.9b00065DOI Listing
February 2019

Laser-Induced Graphene-PVA Composite as Robust Electrically Conductive Water Treatment Membranes.

ACS Appl Mater Interfaces 2019 Feb 22. Epub 2019 Feb 22.

Graphene nanomaterials can feature both a superb electrical conductivity and unique physical properties such as an extreme surface wettability, which is potentially applicable for many purposes including water treatment. Laser-induced graphene (LIG) is an electrically conductive three-dimensional porous carbon material prepared by direct laser writing on various polymers in ambient conditions with a CO2 laser. Low fouling LIG coatings in water technology have been reported, however, the mechanical strength and the separation properties of LIG coated membranes are limited. Read More

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http://dx.doi.org/10.1021/acsami.9b00510DOI Listing
February 2019

The use of tail-anchored protein chimeras to enhance liposomal cargo delivery.

PLoS One 2019 22;14(2):e0212701. Epub 2019 Feb 22.

Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.

Background: Liposomes are employed as drug delivery vehicles offering a beneficial pharmacokinetic/distribution mechanism for in vivo therapeutics. Therapeutic liposomes can be designed to target specific cell types through the display of epitope-specific targeting peptides on their surface. The majority of peptides are currently attached by chemical modification of lipid constituents. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212701PLOS
February 2019

Root-endophytic Chaetomium cupreum chemically enhances aluminium tolerance in Miscanthus sinensis via increasing the aluminium detoxicants, chlorogenic acid and oosporein.

PLoS One 2019 22;14(2):e0212644. Epub 2019 Feb 22.

Advanced Science Research Center, Japan Atomic Energy Agency, Tokaimura, Ibaraki, Japan.

Miscanthus sinensis Andersson is a pioneer plant species that grows naturally at mining sites. Miscanthus sinensis can detoxify aluminium (Al) by producing phytosiderophores, such as chlorogenic acid, citric acid, and malic acid, and localizing Al in cell walls. Root-endophytic Chaetomium cupreum, which produces microbial siderophores, enhances Al tolerance in M. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212644PLOS
February 2019

Salicylic acid as an effective elicitor for improved taxol production in endophytic fungus Pestalotiopsis microspora.

PLoS One 2019 22;14(2):e0212736. Epub 2019 Feb 22.

Department of Biochemistry, Indian Institute of Science, Bangalore, India.

Salicylic acid (SA) is an effective elicitor to increase taxol production in Pestalotiopsis microspora. Addition of SA at the concentration of 300 μM yielded taxol 625.47 μg L-1, 45- fold higher than that of the control. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212736PLOS
February 2019

Screening nested-PCR primer for 'Candidatus Liberibacter asiaticus' associated with citrus Huanglongbing and application in Hunan, China.

PLoS One 2019 22;14(2):e0212020. Epub 2019 Feb 22.

Hunan Provincial Key Laboratory for Biology and Control of Plant Pests, College of Plant Protection, Hunan Agricultural University, Changsha, Hunan province, China.

Citrus Huanglongbing (HLB) is one of the most devastating citrus diseases worldwide. Sensitive and accurate assays are vital for efficient prevention of the spread of HLB-associated "Candidatus Liberibacter spp". "Candidatus Liberibacter spp" that infect Citrus includes "Candidatus Liberibacter asiaticus" (Las), "Candidatus Liberibacter africanus" (Laf) and "Candidatus Liberibacter americanus" (Lam). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212020PLOS
February 2019

Haplotype-phased genome assembly of virulent Phythophthora ramorum isolate ND886 facilitated by long-read sequencing reveals effector polymorphisms and copy number variation.

Mol Plant Microbe Interact 2019 Feb 22. Epub 2019 Feb 22.

Indian Institute of Chemical Biology CSIR, 30156, Structural Biology and bioinformatics, Kolkata, West Bengal, India.

Phytophthora ramorum is a destructive pathogen that causes Sudden Oak Death. The genome sequence of P. ramorum isolate Pr102 was previously produced using Sanger reads, and contained 12 Mb of gaps. Read More

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http://dx.doi.org/10.1094/MPMI-08-18-0222-RDOI Listing
February 2019

Application of the Mechanical High-Pressure Method Combined with High-Performance Liquid Chromatography-Tandem Mass Spectrometry for Determination of Veterinary Drug Residues in Incurred Chicken and Rabbit Muscle Tissues.

J Food Prot 2019 Feb 21:415-421. Epub 2019 Feb 21.

4 Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Hualan Road, Xinxiang 453003, People's Republic of China.

Rapid sample preparation is a key step in the field of food safety. A mechanical high-pressure method using a laboratory-made meat press machine was first introduced in this study to process the incurred muscle samples of chicken and rabbit. By applying high pressure to animal muscle, the meat juice was obtained. Read More

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http://dx.doi.org/10.4315/0362-028X.JFP-18-386DOI Listing
February 2019

M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt.

FASEB J 2019 Feb 22:fj201802351R. Epub 2019 Feb 22.

Institute of Interdisciplinary Integrative Biomedical Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

M1 muscarinic acetylcholine receptors are highly expressed in key areas that control cognition, such as the cortex and hippocampus, representing one potential therapeutic target for cognitive dysfunctions of Alzheimer's disease and schizophrenia. We have reported that M1 receptors facilitate cognition by promoting membrane insertion of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor AMPA receptor subunit 1 (GluA1) through phosphorylation at Ser845. However, the signaling pathway is still unclear. Read More

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http://dx.doi.org/10.1096/fj.201802351RDOI Listing
February 2019

Rational Design of Proton-Electron-Transfer System Based on Nickel Dithiolene Complexes with Pyrazine Skeletons.

Inorg Chem 2019 Feb 22. Epub 2019 Feb 22.

Division of Chemistry, Graduate School of Science , Kyoto University , Kitashirakawa-Oiwakecho , Sakyo-ku , Kyoto 606-8502 , Japan.

To understand the effect of chemical modification on the stability and proton-electron coupling in neutral radical molecules with a proton-electron-transfer (PET) state, we investigate a nickel dithiolene complex with cyano-substituted pyrazine skeletons using experimental and theoretical methods. A Pourbaix diagram constructed from absorption spectroscopic and cyclic voltammetric measurements strongly suggests that the PET state of the complex is significantly more stable compared with that of the nonsubstituted complex. Theoretical calculations predicted that the introduction of electron-withdrawing groups leads to stabilization of the PET state mainly because of a greater delocalized electron distribution in the molecule. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.8b03501DOI Listing
February 2019

Photocatalyst-Free Visible-Light Photoredox Dearomatization of Phenol Derivatives Containing Ketoximes: An Easy Access to Spiropyrrolines.

Org Lett 2019 Feb 22. Epub 2019 Feb 22.

Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry , Tsinghua University , Beijing 100084 , China.

A novel and simple visible-light photoredox intramolecular dearomatization of phenol derivatives containing ketoximes leading to spiropyrrolines has been developed. The protocol uses readily available 1,8-diazabicyclo[5.4. Read More

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http://dx.doi.org/10.1021/acs.orglett.9b00372DOI Listing
February 2019

Competition between Depletion Effects and Coupling in the Plasmon Modulation of Doped Metal Oxide Nanocrystals.

Nano Lett 2019 Feb 22. Epub 2019 Feb 22.

McKetta Department of Chemical Engineering , University of Texas at Austin , Austin , Texas 78712-1589 , United States.

Degenerately doped semiconductor nanocrystals (NCs) exhibit strong light-matter interactions due to localized surface plasmon resonance (LSPR) in the near- to mid-infrared region. Besides being readily tuned through dopant concentration introduced during synthesis, this LSPR can also be dynamically modulated by applying an external electrochemical potential. This characteristic makes these materials candidates for electrochromic window applications. Read More

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http://dx.doi.org/10.1021/acs.nanolett.9b00079DOI Listing
February 2019

Chemical Dynamics Simulation of Energy Transfer: Propylbenzene Cation and N Collisions.

J Phys Chem A 2019 Feb 22. Epub 2019 Feb 22.

Collisional energy transfer of highly vibrationally excited propylbenzene cation in a N bath has been studied with chemical dynamics simulations. In this work, an intermolecular potential of propylbenzene cation interacting with N was developed from SCS-MP2/6-311++G** ab initio calculations. Using a particle swarm optimization(PSO) algorithm, the ab initio results were simultaneously fit to a sum of three two-body potential, consisting of C-N, C-N and H-N, where C is carbon on benzene ring and C is carbon on the propyl side chain. Read More

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http://dx.doi.org/10.1021/acs.jpca.9b00111DOI Listing
February 2019

Bialternacins A-F, Aromatic Polyketide Dimers from an Endophytic Alternaria sp.

J Nat Prod 2019 Feb 22. Epub 2019 Feb 22.

State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences , Nanjing University , Nanjing 210023 , People's Republic of China.

Six novel aromatic polyketide dimers, bialternacins A-F (1-6), were isolated from a plant endophytic Alternaria sp. The structures of compounds 1-6 were elucidated on the basis of extensive spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism analysis. Compounds 1, 2, 5, and 6 were characterized as four pairs of racemic mixtures. Read More

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http://dx.doi.org/10.1021/acs.jnatprod.8b00705DOI Listing
February 2019

A New Class of Superhalogen Based Anion Receptor in Li-ion Battery Electrolytes.

J Chem Inf Model 2019 Feb 22. Epub 2019 Feb 22.

In the search for new additives in Li-ion battery electrolytes especially for LiPF6 and LiClO4, we have theoretically designed boron based complexes by coupling with different heterocyclic ligands. The validation of the formation of modeled compounds involves reproduction of available experimentally reported absolute magnetic shielding and chemical shift values for different boron-complexes. As compared to the commonly used tris (pentaflurophenyl) borane, our designed compounds suggest that the complexes like B[C2HBNO(CN)2]3, B[C2HBNS(CN)2]3 and B[C4H3BN(CN)2]3 are promising additives. Read More

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http://dx.doi.org/10.1021/acs.jcim.9b00035DOI Listing
February 2019

Natural Product Neopeltolide as A Cytochrome bc1 Complex Inhibitor: Mechanism of Action and Structural Modification.

J Agric Food Chem 2019 Feb 22. Epub 2019 Feb 22.

The marine natural product neopeltolide was isolated from a deep-water sponge specimen of the family Neopeltidae. Neopeltolide has been proven to be a new type of inhibitor of the cytochrome bc1 complex in the mitochondrial respiration chain. However, its detailed inhibition mechanism has remained unknown. Read More

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http://dx.doi.org/10.1021/acs.jafc.8b06195DOI Listing
February 2019

Protein Adsorption and Coordination-Based End-Tethering of Functional Polymers on Metal-Phenolic Network Films.

Biomacromolecules 2019 Feb 22. Epub 2019 Feb 22.

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, and the Department of Chemical Engineering , The University of Melbourne , Parkville , Victoria 3010 , Australia.

Metal-phenolic network (MPN) coatings have generated increasing interest owing to their biologically inspired nature, facile fabrication, and near-universal adherence, especially for biomedical applications. However, a key issue in biomedicine is protein fouling, and the adsorption of proteins on tannic acid-based MPNs remains to be comprehensively studied. Herein, we investigate the interaction of specific biomedically relevant proteins in solution (e. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00006DOI Listing
February 2019

Enzymatic Tagging of Glycoproteins on the Cell Surface for Their Global and Site-Specific Analysis with Mass Spectrometry.

Anal Chem 2019 Feb 22. Epub 2019 Feb 22.

The cell surface is normally covered with sugars that are bound to lipids or proteins. Surface glycoproteins play critically important roles in many cellular events, including cell-cell communications, cell-matrix interactions, and response to environmental cues. Aberrant protein glycosylation on the cell surface is often a hallmark of human diseases such as cancer and infectious diseases. Read More

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http://dx.doi.org/10.1021/acs.analchem.9b00441DOI Listing
February 2019

Dynamic Plasmonic Pixels.

ACS Nano 2019 Feb 22. Epub 2019 Feb 22.

Information display utilizing plasmonic color generation has recently emerged as an alternative paradigm to traditional printing and display technologies. However, many implementations so far have either presented static pixels with a single display state or rely on relatively slow switching mechanisms such as chemical transformations or liquid crystal transitions. Here, we demonstrate spatial, spectral, and temporal control of light using dynamic plasmonic pixels that function through the electric field induced alignment of plasmonic nanorods in organic suspensions. Read More

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http://dx.doi.org/10.1021/acsnano.9b00905DOI Listing
February 2019

Salt-Free Reduction of Transition Metal Complexes by Bis(trimethylsilyl)cyclohexadiene, -dihydropyrazine, and -4,4'-bipyridinylidene Derivatives.

Acc Chem Res 2019 Feb 22. Epub 2019 Feb 22.

Department of Chemistry, Graduate School of Engineering Science , Osaka University , Toyonaka , Osaka 560-8531 , Japan.

Chemical reduction of transition metals provides the corresponding low-valent transition metal species as a key step for generating catalytically active species in metal-assisted organic transformations and is a fundamental unit reaction for preparing organometallic complexes. A variety of metal-based reductants, such as metal powders and organometallic reagents of alkali and alkaline-earth metals, have been developed to date to access low-valent metal species. During the reduction, however, reductant-derived metal salts are formed as reaction waste, some of which often interact with the reactive low-valent metal center, thereby disrupting the catalytic performance and hampering the isolation of organometallic complexes as a result of salt coordination to the coordinatively unsaturated vacant and active sites and the formation of thermally unstable ate complexes. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00638DOI Listing
February 2019

LmrR: A Privileged Scaffold for Artificial Metalloenzymes.

Authors:
Gerard Roelfes

Acc Chem Res 2019 Feb 22. Epub 2019 Feb 22.

Stratingh Institute for Chemistry , University of Groningen , Nijenborgh 4 , 9747 AG Groningen , The Netherlands.

The biotechnological revolution has made it possible to create enzymes for many reactions by directed evolution. However, because of the immense number of possibilities, the availability of enzymes that possess a basal level of the desired catalytic activity is a prerequisite for success. For new-to-nature reactions, artificial metalloenzymes (ARMs), which are rationally designed hybrids of proteins and catalytically active transition-metal complexes, can be such a starting point. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00004DOI Listing
February 2019

Soft Materials with Diverse Suprastructures via the Self-Assembly of Metal-Organic Complexes.

Acc Chem Res 2019 Feb 22. Epub 2019 Feb 22.

Department of Chemistry , University of Utah , 315 South 1400 East, Room 2020 , Salt Lake City , Utah 84112 , United States.

Inspired by assemblies in the natural world, researchers have prepared diverse suprastructures with distinct spatial arrangements by artificial self-assembly, including micelles, vesicles, ribbons, films, fibers, and tubes. The field of assembly is undergoing a transition from single-component to multicomponent assembly and single-step to multistep processing. Control over the size, shape, and composition of these building blocks has enabled the formation of suprastructures with substantial structural diversity. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00663DOI Listing
February 2019

[Sugar-Supplemented Substrates Contaminated by Agricultural Inputs Favor the Proliferation of Aedes albopictus (Diptera: Culicidae)].

Authors:
F Darriet

Bull Soc Pathol Exot 2018 ;111(4):205-211

Institut de recherche pour le développement (IRD), MIVEGEC (IRD, CNRS, Université de Montpellier) Maladies infectieuses et vecteurs, écologie, génétique, évolution et contrôle, 911 av. Agropolis, BP 64501, 34394 Montpellier, France.

Originating from South-East Asian tropical forests, Aedes albopictus (Skuse) (Diptera: Culicidae) is a mosquito of great genetic plasticity, which allowed it to adapt to a large variety of environments including the urban ones. Yet many a city nowadays comprises peri urban zones close to land devoted to farming. The sites where Ae. Read More

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http://dx.doi.org/10.3166/bspe-2018-0042DOI Listing
January 2018

Volatile Chemical Composition, Antibacterial and Antifungal Activities of Extracts from Different Parts of Globba schomburgkii Hook. f.

Chem Biodivers 2019 Feb 22. Epub 2019 Feb 22.

Chulalongkorn University, Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Patumwan, Wangmai, 10330, Bangkok, THAILAND.

Globba schomburgkii Hook. f. is an ornamental plant that has recently found increasing demand as cut flowers, hence generating a significant number of by products from different parts of the plant. Read More

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http://dx.doi.org/10.1002/cbdv.201900057DOI Listing
February 2019

Antioxidant and Antiproliferative Activities of Modified Polysaccharides Originally Isolated from Morchella Angusticepes Peck.

J Food Sci 2019 Feb 22. Epub 2019 Feb 22.

College of Food Science, Southwest Univ., Chongqing, 400715, People's Republic of China.

Polysaccharides extracted from Morchella angusticepes Peck (PMEP) were chemically modified to obtain sulfated, carboxymethylated, and acetyled derivatives. Results showed that the acetyled derivatives with the degree of substitution (0.40 ± 0. Read More

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http://dx.doi.org/10.1111/1750-3841.14470DOI Listing
February 2019

Quantitative Proteomic Analysis of A549 Cells Infected with Human Adenovirus Type 2.

J Med Virol 2019 Feb 22. Epub 2019 Feb 22.

Human Virology Laboratory, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Goiás, Brazil.

HAdV-2 is considered a common agent of respiratory tract infection in the human, especially in children. Virus infection is believed to modify host cell expression necessary for its replication and therefore cell proteome can reflect the changes of specific cellular pathways during infection. This study aims to identify differentially expressed proteins of A549 cells in response to HAdV-2 infection using a label-free liquid chromatography-high-resolution tandem mass spectrometry strategy (LC-MS/MS) at 24 and 48 hpi. Read More

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http://dx.doi.org/10.1002/jmv.25439DOI Listing
February 2019

Capturing a dynamically interacting inhibitor by paramagnetic NMR spectroscopy.

Phys Chem Chem Phys 2019 Feb 22. Epub 2019 Feb 22.

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic. and Department of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic.

Transient and fuzzy intermolecular interactions are fundamental to many biological processes. Despite their importance, they are notoriously challenging to characterize. Effects induced by paramagnetic ligands in the NMR spectra of interacting biomolecules provide an opportunity to amplify subtle manifestations of weak intermolecular interactions observed for diamagnetic ligands. Read More

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http://dx.doi.org/10.1039/c9cp00416eDOI Listing
February 2019

Comment on "Revisiting the carrageenan controversy: do we really understand the digestive fate and safety of carrageenan in our foods?" by S. David, C. S. Levi, L. Fahoum, Y. Ungar, E. G. Meyron-Holtz, A. Shpigelman and U. Lesmes, Food Funct., 2018, 9, 1344-1352.

Food Funct 2019 Feb 22. Epub 2019 Feb 22.

IONTOX, LLC, 4717 Campus Dr., Kalamazoo, MI 49008, USA.

Carrageenan (CGN) is a polysaccharide that is found in various types of sea weed. It is a common food additive used for its gelling and thickening properties and has been used safely throughout the world for decades. CGN is approved as Generally Recognized as Safe (GRAS) by the United States Food and Drug Administration and is also considered safe for the general population by the World Health Organizations Joint Expert Committee on Food Additive (JECFA) and the European Food Safety Authority. Read More

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http://dx.doi.org/10.1039/c8fo01282bDOI Listing
February 2019

Formation of disulphide linkages restricts intramolecular motions of a fluorophore: detection of molecular oxygen in food packaging.

Chem Commun (Camb) 2019 Feb 22. Epub 2019 Feb 22.

Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur, Nadia, WB 741246, India.

Reliable and easy detection of oxygen in food packaging without the aid of sophisticated instruments is highly coveted. A tetraphenylethene probe based on oxygen-mediated polymerization via the formation of disulfides causes restricted intramolecular rotation of the TPE phenyls resulting in a >100 fold enhancement of emission and thus detects O2 in food packages. Read More

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http://dx.doi.org/10.1039/c8cc10035gDOI Listing
February 2019

In vitro antioxidant and antinociceptive properties of Porphyra vietnamensis.

Biomedicine (Taipei) 2019 Mar 22;9(1). Epub 2019 Feb 22.

Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh-201313, India.

Background: Current investigation explores the anti-oxidant and antinociceptive potential of edible seaweed namely Porphyra vietnamensis.

Methods: Radical scavenging and antinociceptive potential of ethanolic (EE), aqueous (AE), acetone (ACE) and chloroform (CE) fractions were determined using various models and assays. Writhing, formalin, hot plate, acetic acid induce response models were performed to determine antinociceptive activity whereas different assays have been used to determine antioxidant potential. Read More

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http://dx.doi.org/10.1051/bmdcn/2019090103DOI Listing

Analysis of the Spatial Distribution of Collectors in Dust Scrubber based on Image Processing.

J Air Waste Manag Assoc 2019 Feb 22. Epub 2019 Feb 22.

d School of Safety Engineering, China University of Mining and Technology , Xuzhou 221008 , China.

The spatial distribution of the collectors in dust scrubber is key in determining the effectiveness of the dust removal process. In the present study, a high-speed camera was used to capture images of the distribution of the collectors. Some of the image information was extracted by image processing, such as the gray mean (GM), the angular second moment (ASM), and the entropy (ENT) from the gray-level co-occurrence matrix of the image. Read More

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http://dx.doi.org/10.1080/10962247.2019.1586012DOI Listing
February 2019

Structural insights into the anti-cancer activity of quercetin on G-tetrad, mixed G-tetrad, and G-quadruplex DNA using quantum chemical and molecular dynamics simulations.

J Biomol Struct Dyn 2019 Feb 22:1-23. Epub 2019 Feb 22.

a Department of Physics , Bharathiar University , Coimbatore , Tamil Nadu, India.

Human telomerase referred as 'terminal transferase' is a nucleoprotein enzyme which inhibits the disintegration of telomere length and act as a drug target for the anticancer therapy. The tandem repeating structure of telomere sequence forms the guanine-rich quadruplex structures that stabilize stacked tetrads. In our present work, we have investigated the interaction of quercetin with DNA tetrads using DFT. Read More

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http://dx.doi.org/10.1080/07391102.2019.1574239DOI Listing
February 2019

Cross-linked esterase aggregates (CLEAs) using nanoparticles as immobilization matrix.

Prep Biochem Biotechnol 2019 Feb 22:1-9. Epub 2019 Feb 22.

a Center for Biotechnology , Anna University , Chennai , India.

The present study focusses on the enhancement of the catalytic activity and stability of an acetylesterase enzyme isolated from Staphylococcus spp. as Cross-Linked Enzyme Aggregates (CLEAs). The various parameters governing the activity of CLEAs were optimized. Read More

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http://dx.doi.org/10.1080/10826068.2018.1536993DOI Listing
February 2019

Pulmonary toxicity following inhalation exposure to VX in anesthetized rats: Possible roles for compromised immunity and oxidative stress-induced lung injury.

Exp Lung Res 2019 Feb 22:1-18. Epub 2019 Feb 22.

a Biochemical and Physiology Branch, Medical Toxicology Research Division , United States Army Medical Research Institute of Chemical Defense , Aberdeen Proving Ground , Maryland , USA.

The nerve agent VX is one of the most deadly threat agents available in weapons stockpiles for intentional release. While mostly considered a percutaneous toxicant, it can be fatal when aerosolized. The objective of this study was to investigate toxic responses in the lung up to two weeks following a single 10-minute exposure to inhaled VX. Read More

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http://dx.doi.org/10.1080/01902148.2018.1519003DOI Listing
February 2019

Combinatorial Synthesis to Identify a Potent, Necrosis-Inducing Rhenium Anticancer Agent.

Inorg Chem 2019 Feb 22. Epub 2019 Feb 22.

Department of Chemistry and Chemical Biology , Cornell University , Ithaca , New York 14853 , United States.

Combinatorial synthesis can be applied for developing a library of compounds that can be rapidly screened for biological activity. Here, we report the application of microwave-assisted combinatorial chemistry for the synthesis of 80 rhenium(I) tricarbonyl complexes bearing diimine ligands. This library was evaluated for anticancer activity in three different cancer cell lines, enabling the identification of three lead compounds with cancer cell growth-inhibitory activities of less than 10 μM. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.8b03552DOI Listing
February 2019

BN-Functionalized Benzotrithiophene-Based Azaborines: Synthesis, Structures, and Anion Binding Properties.

Inorg Chem 2019 Feb 22. Epub 2019 Feb 22.

Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, School of Chemistry and Chemical Engineering , Beijing Institute of Technology of China , Beijing 102488 , People's Republic of China.

Facile synthesis of BN-functionalized azaborines (4a-4c) was accomplished via Suzuki coupling reactions followed by the electrophilic C-H borylation of benzotrithiophene (BTT). The core structure of BTT enables multiple modifications at the three thiophene rings. Molecular structures of 4a-4c were confirmed by NMR, high-resolution mass spectrometry, and X-ray crystallographic analysis. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.8b03579DOI Listing
February 2019

Dynamical Correlations for Statistical Copolymers from High-Throughput Broad-Band Dielectric Spectroscopy.

ACS Comb Sci 2019 Feb 22. Epub 2019 Feb 22.

Department of Chemical and Biomedical Engineering , University of South Florida , Tampa , Florida 33620 , United States.

Broad-band dielectric spectroscopy (BDS) provides a powerful method of characterizing relaxation dynamics in diverse materials. Here we describe and employ a novel instrument for high-throughput broad-band dielectric spectroscopy (HTBDS) that accelerates this capability, enabling simultaneous measurements of 48 samples. This capability is based around a coaxial switching system for rapid scanning between multiple samples on the same sample stage, coordinated with shared environmental control. Read More

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http://dx.doi.org/10.1021/acscombsci.8b00160DOI Listing
February 2019

Catalytic Converters for Water Treatment.

Acc Chem Res 2019 Feb 22. Epub 2019 Feb 22.

Nanotechnology Enabled Water Treatment (NEWT) Center , 6100 Main Street , Houston , Texas 77005 , United States.

Fresh water demand is driven by human consumption, agricultural irrigation, and industrial usage and continues to increase along with the global population. Improved methods to inexpensively and sustainably clean water unfit for human consumption are desired, particularly at remote or rural locations. Heterogeneous catalysts offer the opportunity to directly convert toxic molecules in water to nontoxic products. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00642DOI Listing
February 2019
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