1,361,560 results match your criteria Chemical communications Cambridge England[Journal]


The impact of hydroelectric dams on mercury dynamics in South America: A review.

Chemosphere 2018 Dec 6;219:546-556. Epub 2018 Dec 6.

Programa de Pós-Graduação Em Ecologia e Recursos Naturais, Laboratório de Ciências Ambientais, Centro de Biociências e Biotecnologia, Universidade Estadual Do Norte Fluminense Darcy Ribeiro, Av. Alberto Lamego, 2000 - Parque Califórnia, CEP: 28013-602, Campos Dos Goytacazes, Rio de Janeiro, Brazil.

The increase in global demand for electric energy is reflected in plans to construct numerous hydroelectric dams in South America that can cause chronic ecological impacts if not built and managed correctly. One of the main impacts generated by hydropower dams is the accumulation of Hg chemical species in their reservoir compartments and the downstream transport of these contaminants. Hg circulation in these environments has been studied for 27 years and this review brings a synthesis of the dynamics that are now well established, so that future studies can focus on gaps and inconsistent results in the literature. Read More

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December 2018

Concentrations, speciation, and ecological risk of heavy metals in the sediment of the Songhua River in an urban area with petrochemical industries.

Chemosphere 2018 Dec 10;219:538-545. Epub 2018 Dec 10.

Jilin Institute of Chemical Technology, Jilin, 132022, China. Electronic address:

In this study, the pollution status and the ecological risks of heavy metals (Cu, Zn, Pb, Ni and Cr) in the sediments of the Songhua River in an urban area with petrochemical industries were assessed. The highest mean concentration of total heavy metals occurred in the freezing period, and the highest total heavy metal concentrations were observed near the petrochemical industrial area. The geo-accumulation index indicated that Cu was the most contaminated heavy metal. Read More

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December 2018

Stored potential energy increases and elastic properties alterations are produced after restoring dentin with Zn-containing amalgams.

J Mech Behav Biomed Mater 2018 Dec 6;91:109-121. Epub 2018 Dec 6.

University of Granada, Faculty of Dentistry, Dental Materials Section, Colegio Máximo de Cartuja s/n, 18071 Granada, Spain.

The aim of this research was to ascertain the mechanical and chemical behavior of sound and caries-affected dentin (CAD), after the placement of Zn-free vs containing amalgam restorations. Peritubular and intertubular dentin were evaluated using, a) nanoindenter in scanning mode; the load and displacement responses were used to perform the nano-Dynamic mechanical analysis and to estimate the complex (E * ) and storage modulus (E'); b) Raman spectroscopy was used to describe the hierarchical cluster analysis (HCA). Assessments were performed before restoration placement and after restoring, and after 3 months of storage with thermocycling (100,000cy/5 °C and 55 °C). Read More

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December 2018

Preparation of pH-responsive avermectin/feather keratin-hyaluronic acid with anti-UV and sustained-release properties.

Colloids Surf B Biointerfaces 2018 Dec 6;175:291-299. Epub 2018 Dec 6.

School of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, PR China. Electronic address:

In an effort to improve the utilization of pesticides, an environmentally friendly carrier material was prepared to encapsulate pesticides and to prevent pesticides from decomposing under natural conditions with sustained-release effect. The carrier of feather keratin-hyaluronic acid (FK-HA) was prepared by Maillard reaction. Using avermectin (AVM) as a model drug, AVM/FK-HA was obtained by heating. Read More

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December 2018
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Urinary levels of bisphenol A, F and S and markers of oxidative stress among healthy adult men: Variability and association analysis.

Environ Int 2018 Dec 12;123:301-309. Epub 2018 Dec 12.

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address:

Background: Bisphenol F (BPF) and bisphenol S (BPS) are increasingly used as alternatives to endocrine disrupting chemical bisphenol A (BPA). Evidence from in vitro and animal studies demonstrates that BPA, BPF and BPS induce oxidative stress, a proposed mechanism that is relevant to various adverse health effects. Evaluation in humans is hampered by the potentially high within-subject variability of urinary measurements. Read More

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December 2018

Molecular simulation of the structure of folate and antifolates at physiological conditions.

J Mol Graph Model 2018 Dec 4;87:172-184. Epub 2018 Dec 4.

Laboratory of Quantum and Computational Chemistry, Faculty of Chemistry and Pharmacy, University of Sofia, 1 James Bourchier Blvd, 1164, Sofia, Bulgaria. Electronic address:

The study is focused on description of folate and several antifolates at physiological conditions. Knowledge of the molecular structure and dynamics is important for understanding their biological activity and therapeutic application. They are modelled in saline by atomistic molecular dynamics simulations and characterized in detail. Read More

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December 2018
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Excess copper promotes photoinhibition and modulates the expression of antioxidant-related genes in Zostera muelleri.

Aquat Toxicol 2018 Dec 5;207:91-100. Epub 2018 Dec 5.

Climate Change Cluster, University of Technology Sydney, NSW, Australia.

Copper (Cu) is an essential micronutrient for plants and as such is vital to many metabolic processes. Nevertheless, when present at elevated concentrations, Cu can exert toxic effects on plants by disrupting protein functions and promoting oxidative stress. Due to their proximity to the urbanised estuaries, seagrasses are vulnerable to chemical contamination via industrial runoff, waste discharges and leachates. Read More

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December 2018

Near-infrared excited cooperative upconversion in luminescent Ytterbium(ΙΙΙ) bioprobes as light-responsive theranostic agents.

Eur J Med Chem 2018 Dec 5;163:546-559. Epub 2018 Dec 5.

Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, 208016, UP, India. Electronic address:

Near-infrared (NIR) Ytterbium(ΙΙΙ) complexes namely [Yb(dpq)(DMF)Cl] (1), [Yb(dppz)(DMF)Cl] (2), [Yb(dpq)(ttfa)] (3) and [Yb(dppz)(ttfa)] (4) based on photosensitizing antenna: dipyrido-[3,2-d:2',3'-f]-quinoxaline (dpq), dipyrido-[3,2-a:2',3'-c]-phenazine (dppz) and 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione (Httfa), were designed as NIR bioimaging agents utilizing cooperative upconversion luminescence (CUCL) of Yb(III). Their structures, detailed photophysical properties, biological interactions, photo-induced DNA cleavage, NIR photocytotoxicity and cellular internalization and bioimaging properties were examined. Discrete mononuclear complexes adopt a seven-coordinated {LnNOCl} mono-capped octahedron (1, 2) and eight-coordinated {LnNO} distorted square antiprism geometry (3, 4) with bidentate N, N-donor dpq, dppz and O,O-donor ttfa ligands. Read More

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December 2018

Study on anti-hyperuricemia effects and active ingredients of traditional Tibetan medicine TongFengTangSan (TFTS) by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.

J Pharm Biomed Anal 2018 Nov 17;165:213-223. Epub 2018 Nov 17.

Jiangxi University of Traditional Chinese Medicine, No. 1688 Meiling Road, Nanchang, 330004, PR China. Electronic address:

TongFengTangSan (TFTS), a traditional Tibetan medicine comprising of Tinospora sinensis (TS), Terminalia chebula Retz (TC) and Trogopterori faeces (TF), is used to treat joint diseases like gout, gout arthritis, swelling, pain etc. Despite the significant therapeutic effects of TFTS, its pharmacological components have not been analyzed so far. Therefore, the chemical composition of the effective part of TFTS was analyzed by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS). Read More

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November 2018

Bubble-free rapid microfluidic PCR.

Biosens Bioelectron 2018 Oct 11;126:725-733. Epub 2018 Oct 11.

Department of Bioengineering, University of California Berkeley, CA 94720, USA; Berkeley Sensor and Actuator Center, University of California Berkeley, CA 94720, USA; UC Berkeley and UCSF Joint Graduate Program in Bioengineering, Berkeley/San Francisco, USA; Department of Electrical Engineering and Computer Science, University of California Berkeley, CA 94720, USA; Biophysics Graduate Program, University of California Berkeley, CA 94720, USA. Electronic address:

Microfluidic polymerase chain reaction (PCR) has been of great interest owing to its ability to perform rapid and specific nucleic acid amplification and analysis on small volumes of samples. One of the major drawbacks of microfluidic PCR is bubble generation and reagent evaporation, which can cause malfunctions. Here, through theoretical modeling and characterization of bubble behavior, we propose a bubble-free microfluidic PCR device via controlled fluid transfer. Read More

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October 2018
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An acid-pasting approach towards perylenetetracarboxylic diimide based lithium/sodium ion battery cathodes with high rate performances.

J Colloid Interface Sci 2018 Nov 23;538:597-604. Epub 2018 Nov 23.

National Engineering Lab for TFT-LCD Materials and Technologies, Department of Electronic Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, People's Republic of China. Electronic address:

An acid-pasting approach is developed in this work to fabricate the composite of perylenetetracarboxylic diimide (PTCDI) and carbon black in concentrated sulfuric acid. Different from traditional mechanical mixing, the solution-based fabrication strategy enables the sufficient blending of PTCDI as active component and carbon black as conductive agent in the PTCDI/CB composite. Serving as the cathode material, the PTCDI/CB composite shows excellent electrochemical performances in both lithium ion battery (137 mAh g at 100 mA g and 110 mAh g at 2000 mA g) and sodium ion battery (134 mAh g at 100 mA g and 99 mAh g at 1000 mA g), which are comparable to the state-of-art organic/inorganic cathode materials. Read More

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November 2018

Noble metal nanoparticle-functionalized Zr-metal organic frameworks with excellent photocatalytic performance.

J Colloid Interface Sci 2018 Dec 6;538:569-577. Epub 2018 Dec 6.

College of Chemical Engineering, Jiangsu Key Lab for the Chemistry & Utilization of Agricultural and Forest Biomass, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing, Jiangsu 210037, China. Electronic address:

Noble metal nanoparticles (NPs) functionalized MOFs are attractive materials for photocatalytic reactions, and outstanding catalytic performances can be expected, especially when they have intrinsically matched crystal faces between metals and MOFs. This study discovered that the photocatalytic oxidation of aromatic alcohols to aldehydes was enhanced over Au/UiO-66-NH or Au/UiO-66 but suppressed over Pt loaded counterparts, whereas the reduction of Cr(VI) was boosted over both two catalysts. In reactions, the conversion of benzyl alcohol was 17. Read More

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December 2018
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Performance and microbial community of an electric biological integration reactor (EBIR) for treatment of wastewater containing ibuprofen.

Bioresour Technol 2018 Dec 7;274:447-458. Epub 2018 Dec 7.

School of Civil Engineering and Architecture, University of Jinan, Jinan 250022, China; School of Civil Engineering and Architecture, Qilu Institute of Technology, Jinan 250022, China.

Electric biological integration reactor (EBIR) was designed and built for the treatment of wastewater containing ibuprofen. This study evaluates the removal performance of EBIR by comparison with biological aerated filter (BAF), while also discussing the optimal operational parameters of EBIR within the context of the response surface methodology. The results indicate that EBIR exhibits higher average removal rates of ibuprofen, chemical oxygen demand (COD) and NH-N, i. Read More

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December 2018

Pyrolysis of blend (oil palm biomass and sawdust) biomass using TG-MS.

Bioresour Technol 2018 Dec 7;274:439-446. Epub 2018 Dec 7.

Mechanical Engineering Discipline, School of Engineering, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia.

The aim of this study was to pyrolyze individual (oil palm shell, empty fruit bunch and sawdust) as well as blend biomass in a thermogravimetric mass spectrometry (TG-MS) from room temperature to 800 °C at constant heating rate of 15 °C/min. The results showed that the onset TG temperature for blend biomass shifted slightly to lower values. Activation energy values were also found to decrease slightly after blending the biomass. Read More

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December 2018
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Design of a randomized controlled trial on the efficacy of a reproductive health survivorship care plan in young breast cancer survivors.

Contemp Clin Trials 2018 Dec 12. Epub 2018 Dec 12.

Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Dr. La Jolla, CA 92093-090, USA; Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Diego, 9300 Campus Pointe Drive, MC 7433, La Jolla, CA 92037, USA. Electronic address:

Background: Young breast cancer survivors (YBCS) have unmet needs for managing hot flashes, fertility-related concerns, sexual health and contraception.

Purpose: Describe the design and participant characteristics of a randomized controlled trial testing the efficacy of the survivorship care plan on reproductive health (SCP-R) intervention on improving hot flashes, fertility-related concerns, sexual health, and contraception in YBCS.

Methods: SCP-R is a web-based intervention with text message support encompassing evidence- based practices on four reproductive health issues. Read More

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December 2018

Triphenyltin(IV) acylhydrazone compounds: Synthesis, structure and bioactivity.

J Inorg Biochem 2018 Nov 24;191:194-202. Epub 2018 Nov 24.

Institute of Anticancer Agents Development and Theranostic Application, The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China. Electronic address:

Four new triphenyltin(IV) acylhydrazone compounds of the type PhSnCHCHCONHN=R (where Ph = phenyl; R = isopropyl, isobutyl, cyclopentyl and cyclooctyl) were synthesized and characterized by elemental analysis, infrared spectrum (IR), nuclear magnetic resonance spectrum (NMR) and mass spectrum (MS). The crystal structures were determined and showed that tin atoms were four-coordinated and adopted a pseudo-tetrahedron configuration. Tin(IV) compounds show excellent bovine serum albumin (BSA) binding properties, and can oxidize nicotinamide-adenine dinucleotid (NADH) to generate reactive oxygen species (ROS), which inducing apoptosis effectively. Read More

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November 2018

Genetic susceptibility to Tuberculosis: Interaction between HLA-DQA1 and age of onset.

Infect Genet Evol 2018 Dec 12. Epub 2018 Dec 12.

Department of Microbiology, The Chinese University of Hong Kong, Hong Kong, China.

Several genome-wide association studies (GWAS) identified new single nucleotide polymorphisms (SNPs) with susceptibility to Tuberculosis (TB). However, many of them were not replicated across ethnic groups. The cause of this phenomenon of genetic heterogeneity is uncertain. Read More

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December 2018

Improved anti-colorectal carcinomatosis effect of tannic acid co-loaded with oxaliplatin in nanoparticles encapsulated in thermosensitive hydrogel.

Eur J Pharm Sci 2018 Dec 12. Epub 2018 Dec 12.

State Key Laboratory of Biotherapy and Cancer Center and Department of Neurosurgery, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu 610041, PR China. Electronic address:

Tannic acid, a hydrolysable tannin, exists commonly in food plants. Tannic acid has already been shown various anticancer mechanisms such as inhibiting the proliferation, inducing a higher apoptotic rate and slowing down the metastasis of different cancers. Moreover, tannic acid was reported to reduce the side effects caused by chemotherapeutics on patients. Read More

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December 2018

Enhancement of the apparent solubility and bioavailability of Tadalafil nanoparticles via antisolvent precipitation.

Eur J Pharm Sci 2018 Dec 12. Epub 2018 Dec 12.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China. Electronic address:

The ability to increase the bioavailability and dissolution of poorly soluble hydrophobic drugs has been a major challenge for pharmaceutical development. This study shows that the dissolution rate, apparent solubility and oral bioavailability of tadalafil (Td) can be improved by nano-sized amorphous particles prepared by using antisolvent precipitation. Acetone and an acetone-water solution (v:v, 9:1) were selected as solvents, with deionized water as the antisolvent. Read More

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December 2018
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Composite nanofibrous membranes of PLGA/Aloe vera containing lipid nanoparticles for wound dressing applications.

Int J Pharm 2018 Dec 12. Epub 2018 Dec 12.

NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), Spain; Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria-Gasteiz, Spain. Electronic address:

Electrospun nanofibrous dressings present suitable characteristics to be used in wound healing, such as high porosity and high surface area-to-volume ratio. In this study, a wound dressing based on PLGA and Aloe vera containing lipid nanoparticles (NLCs) was developed. NLCs were added in order to add a lipid component that could avoid the adhesion of the dressing to the wound and improve its handling. Read More

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December 2018

Automated small-scale in vitro transfer model as screening tool for the prediction of in vivo-dissolution and precipitation of poorly solubles.

Int J Pharm 2018 Dec 12. Epub 2018 Dec 12.

Institute of Pharmacy, Department of Biopharmaceutics and Pharmaceutical Technology, University of Greifswald, Felix-Hausdorff-Strasse 3, 17489 Greifswald, Germany. Electronic address:

Precipitation testing, especially for weakly basic APIs, represents a key parameter in drug substance characterization during early development stages, where the amount of API available is limited. Therefore, it was the aim of this study to develop an automated small-scale in vitro transfer model to characterize the supersaturation and precipitation behavior of two poorly water-soluble drugs. Following automation and scale-down of the standard transfer model, the developed small-scale model was used to assess the impact of gastrointestinal variability, i. Read More

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December 2018

A comprehensive analysis and optimization of continuous twin-screw granulation processes via sequential experimentation strategy.

Int J Pharm 2018 Dec 12. Epub 2018 Dec 12.

Department of Pharmaceutics, Rutgers University, Piscataway, NJ 08854, USA; Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ 08854, USA. Electronic address:

Nowadays twin-screw granulation has been emerging as an attractive continuous wet granulation technique. This study was geared towards better process design and understanding with emphasis on bridging the knowledge gap between input and output variables by employing sequential experimentation strategy. A low-dose formulation for granulation experiments contained anhydrous caffeine as the model drug. Read More

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December 2018

Emex spinosa (L.) Campd. ethyl acetate fractions effects on inflammatory mediators and oxidative stressmarkers in carrageenan induced paw oedema in mice.

J Ethnopharmacol 2018 Dec 12. Epub 2018 Dec 12.

Biopesticides Laboratory (LPIP), Center of Biotechnology of Sfax, University of Sfax, P.O. Box. 1177, 3018 Sfax, TUNISIA. Electronic address:

Ethnopharmacological Relevance: Emex spinosa (L.) Campd. (E. Read More

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December 2018
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Selective CB2 inverse agonist JTE907 drives T cell differentiation towards a Treg cell phenotype and ameliorates inflammation in a mouse model of inflammatory bowel disease.

Pharmacol Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Medicine, Section of Pharmacology, University of Perugia, Italy.

Cannabinoids are known to possess anti-inflammatory and immunomodulatory properties, but the mechanisms involved are not fully understood. CB2 is the cannabinoid receptor that is expressed primarily on hematopoietic cells and mediates the immunoregulatory functions of cannabinoids. In order to study the effect of JTE907, a selective/inverse agonist of CB2 with anti-inflammatory properties, on the differentiation of T cell subtypes, we used an in vitro system of Th lineage-specific differentiation of naïve CD4 T lymphocytes isolated from the mouse spleen. Read More

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December 2018
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Sustained release of recombinant thrombomodulin from cross-linked gelatin/hyaluronic acid hydrogels potentiate wound healing in diabetic mice.

Eur J Pharm Biopharm 2018 Dec 12. Epub 2018 Dec 12.

nstitute of Clinical Pharmacy and Pharmaceutical Sciences, Southern Taiwan University of Science and Technology, Tainan, Taiwan. Electronic address:

Thrombomodulin (TM) is a type-I transmembrane glycoprotein expressed on the surfaces of endothelial cells and epidermal keratinocytes. It is known to regulate blood coagulation, inflammation, and cell-cell adhesion. A recombinant TM, which contains an epidermal growth factor - like domain and serine/threonine-riches domain, has been demonstrated to stimulate cell proliferation and migration of keratinocytes and wound healing. Read More

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December 2018

Biogenic nanomaterials: Synthesis, characterization, growth mechanism, and biomedical applications.

J Microbiol Methods 2018 Dec 12. Epub 2018 Dec 12.

School of Pharmacy, Sungkyunkwan University, 2066 Seoburo, Jangan-gu, Suwon, Gyeonggido 16419, Republic of Korea. Electronic address:

The biosynthesis of nanomaterials is a huge and intensifying field of research due to their application in various areas, in particular the biomedical and pharmaceutical fields. In this review, we focused on the biosynthesis of both metallic and semiconductor nanomaterials and their application in biomedicine and pharmaceutics. In order to meet an exponentially increasing need for nanostructured materials, the biological route for the synthesis of nanomaterials will have to be explored, offering advantages over chemical and physical methods as a simpler, more cost effective, and environmentally friendly method, and for which there is no need to use high pressure and temperatures or toxic chemicals. Read More

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December 2018

Development of Nanoparticles for Drug Delivery to Brain Tumor: The Effect of Surface Materials on Penetration into Brain Tissue.

J Pharm Sci 2018 Dec 12. Epub 2018 Dec 12.

Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585, Singapore. Electronic address:

Surface modified PLGA nanoparticles were fabricated via nanoprecipitation for obtaining therapeutic concentration of paclitaxel (PTX) in brain tumor. The cellular uptake and cytotoxicity of NPs were evaluated on C6 glioma cells in vitro and BALB/c mice were used to study the brain penetration and bio-distribution upon intravenous administration. Results showed that by finely tuning nanoprecipitation parameters, PLGA nanoparticles coated with surfactants with a size around 150nm could provide a sustained release of PTX for >2 weeks. Read More

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December 2018
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Preparation and drug release property of tanshinone IIA loaded chitosan-montmorillonite microspheres.

Int J Biol Macromol 2018 Dec 12. Epub 2018 Dec 12.

College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address:

In this study, a biocompatible chitosan/montmorillonite (CS/MMT) composite microsphere was developed as a carrier for loading and sustained-release of the hydrophobic drug of tanshinone IIA. Though the compatibility between hydrophobic drugs and hydrophilic matrix was fairly poor, tanshinone IIA was successfully loaded on the microsphere by the solvent exchange process during chitosan matrix dehydration. The microstructure of the resulting microspheres was characterized with several techniques, such as X-ray diffraction (XRD), thermo-gravimetric analysis (TGA), Fourier transform infrared spectroscopy (FT-IR), and scanning electron microscope (SEM). Read More

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December 2018

Superparamagnetic Iron Oxides as MPI Tracers: A Primer and Review of early applications.

Authors:
J W M Bulte

Adv Drug Deliv Rev 2018 Dec 12. Epub 2018 Dec 12.

Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, Department of Chemical & Biomolecular Engineering, Department of Biomedical Engineering, and Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

Magnetic particle imaging (MPI) has recently emerged as a non-invasive, whole body imaging technique that detects superparamagnetic iron oxide (SPIO) nanoparticles similar as those used in magnetic resonance imaging (MRI). Based on tracer "hot spot" detection instead of providing contrast on MRI scans, MPI has already proven to be truly quantitative. Without the presence of endogenous background signal, MPI can also be used in certain tissues where the endogenous MRI signal is too low to provide contrast. Read More

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December 2018

LeishInDB: a web-accessible resource for small molecule inhibitors against Leishmania sp.

Acta Trop 2018 Dec 12. Epub 2018 Dec 12.

Department of Molecular Biology/Bioinformatics Centre, Rajendra Memorial Research Institute of Medical Science, Indian Council for Medical Research, Agamkuan, Patna, Bihar 800007. India.

Despite the availability of drugs to treat Leishmaniasis, various other factors including drug resistance and adverse side effects encourage the researchers to search for new strategies and alternatives for treating Leishmaniasis. Repurposing and devising combination therapy with the existing small molecules would serve as an alternative strategy to address the issue, especially the drug resistance. Hence, here we report LeishInDB, a web-accessible resource of small molecule inhibitors having a varying degree of activity towards Leishmania sp. Read More

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December 2018
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Phage-based assay for rapid detection of bacterial pathogens in blood by Raman spectroscopy.

J Immunol Methods 2018 Dec 12. Epub 2018 Dec 12.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy. Electronic address:

Sepsis is a systemic inflammatory response ensuing from presence and persistence of microorganisms in the bloodstream. The possibility to identify them at low concentrations may improve the problem of human health and therapeutic outcomes. So, sensitive and rapid diagnostic systems are essential to evaluate bacterial infections during the time, also reducing the cost. Read More

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December 2018
2 Reads

Effect of radiotherapy on the chemical composition of root dentin.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Restorative Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Background: The radiotherapy can directly affect the bond strength of the adhesive materials, interfering in the prognosis of restorative treatments, which may be caused by chemical changes in dentin structure.

Methods: Twenty inferior homologues premolars were distributed in 2 groups (in vitro study) (n = 10): nonirradiated and irradiated. The specimens were submitted to the analysis of phosphate (ν PO ;ν PO ;ν PO ), carbonate (ν CO ), amide I, CH , amide III, and amide I/III ratio by confocal Raman spectroscopy. Read More

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December 2018

Characterization of two steroid hydroxylases from different Streptomyces spp. and their ligand-bound and -unbound crystal structures.

FEBS J 2018 Dec 15. Epub 2018 Dec 15.

Department of Life Science and Biochemical Engineering, Sunmoon University, Asansi, 31460, Republic of Korea.

Bacterial cytochrome P450 (CYP) enzymes are involved in the hydroxylation of various endogenous substrates while using a heme molecule as a cofactor. CYPs have gained biotechnological interest as useful biocatalysts capable of altering chemical structures by adding a hydroxyl group in a regiospecific manner. Here, we identified, purified, and characterized two CYP154C4 proteins from Streptomyces sp. Read More

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December 2018

Anaphylactic reaction caused by skin contact with disinfectant chloramine-T.

Contact Dermatitis 2018 Dec 15. Epub 2018 Dec 15.

Department of Dermatology, University of Groningen, University Medical Center Groningen, The Netherlands.

Chloramine-T (CAS no. 7080-50-4, syn. sodium p-toluenesulfonchloramide) is a crystalline powder on a chlorine basis, commonly used as a sterilizer, antiseptic, disinfectant and chemical reagent. Read More

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December 2018
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Thioamide-bridged nucleic acid (thioAmNA) bearing thymine or 2-thiothymine: Duplex forming ability, base discrimination, and enzymatic stability.

Chembiochem 2018 Dec 14. Epub 2018 Dec 14.

Osaka University, Graduate School of Pharmaceutical Sciences, 1-6 Yamadaoka, 565-0871, Suita, JAPAN.

Because oligonucleotides containing bridged nucleic acids (BNAs) show high duplex-forming ability toward target single-stranded RNA, many BNA analogs have been developed for antisense applications. Amide-bridged nucleic acid (AmNA), which is a BNA analog bearing an amide bond at the bridge, exhibits high duplex-forming ability, enzymatic stability, and antisense activity; thus, AmNA represents a promising BNA scaffold. The high enzymatic stability of AmNA is presumably attributable to the bulky amide structure because it inhibits the access of nucleases to the phosphodiester linkage. Read More

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December 2018

PUMA induction mediates acetaminophen-induced necrosis and liver injury.

Hepatology 2018 Dec 14. Epub 2018 Dec 14.

UPMC Hillman Cancer Center, Pittsburgh, PA, 15213, USA.

Acetaminophen (APAP) overdose is one of the leading causes of hepatotoxicity and acute liver failure in the United States. Accumulating evidence suggests that hepatocyte necrosis plays a critical role in APAP-induced liver injury. However, the mechanisms of APAP-induced necrosis and liver injury are not fully understood. Read More

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December 2018

Photoautotrophic synthesis of butyrate by metabolically engineered cyanobacteria.

Biotechnol Bioeng 2018 Dec 14. Epub 2018 Dec 14.

Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.

Direct conversion of carbon dioxide into chemicals using engineered autotrophic microorganisms offers a potential solution for both sustainability and carbon mitigation. Butyrate is an important chemical used in various industries, including fragrance, food, and plastics. A model cyanobacterium Synechococcus elongatus PCC 7942 was engineered for the direct photosynthetic conversion of CO to butyrate. Read More

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December 2018

Biosensor-Assisted Engineering of a High-Yield Pichia pastoris Cell-Free Protein Synthesis Platform.

Biotechnol Bioeng 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemical Engineering, Imperial College London, London, UK.

Cell-free protein synthesis (CFPS) has recently undergone a resurgence partly due to the proliferation of synthetic biology. The variety of hosts used for cell-free extract production has increased, which harnesses the diversity of cellular biosynthetic, protein folding, and posttranslational modification capabilities available. Here we describe a CFPS platform derived from Pichia pastoris, a popular recombinant protein expression host both in academia and the biopharmaceutical industry. Read More

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December 2018

A three dimensional microfluidized liver system to assess hepatic drug metabolism and hepatotoxicity.

Biotechnol Bioeng 2018 Dec 14. Epub 2018 Dec 14.

Center for Advanced Biomaterials for HealthCare@CRIB, Istituto Italiano di Tecnologia, Largo Barsanti e Matteucci 53, Naples, Italy.

In this work we propose the design and fabrication of a liver system on chip. We first chose the most suitable 3D liver-like model between cell spheroids and microtissue-precursors, both based on the use of hepatocellular carcinoma cells (HepG2) to provide proof-of-concept data. Spheroids displayed high cell density but low expression of the typical hepatic biomarkers, while microtissue-precursors showed stable viability and function over the entire culture time. Read More

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December 2018

Process Analytical Technology Implementation for Protein Refolding: GCSF as a Case Study.

Biotechnol Bioeng 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemical Engineering, Indian Institute of Technology, Hauz Khas, India.

Process analytical technology is gaining interest in the biopharmaceutical industry as a means to enable consistency in processing and thereby in product quality via process control. Protein refolding is known to be significantly impacted by critical process parameters and feed material attributes including composition and pH of the solubilization and refolding buffers. Hence, in order to achieve robust process control and product quality, these attributes and parameters need to be monitored. Read More

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December 2018

H, C, and N backbone resonance assignments for KPC-2, a class A serine-β-lactamase.

Biomol NMR Assign 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemistry and Biochemistry, Miami University, 651 E. High St, Oxford, OH, 45056, USA.

The ever-increasing occurrence of antibiotic resistance presents a major threat to public health. Specifically, resistance conferred by β-lactamases places the efficacy of currently available antibiotics at risk. Klebsiella pneumoniae carbapenemase-2 (KPC-2) is a β-lactamase that enables carbapenem resistance and represents a clear and present danger to global public health. Read More

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December 2018
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Cell-Based Model of the Generation and Maintenance of the Shape and Structure of the Multilayered Shoot Apical Meristem of Arabidopsis thaliana.

Bull Math Biol 2018 Dec 14. Epub 2018 Dec 14.

Department of Mathematics, University of California, Riverside, USA.

One of the central problems in animal and plant developmental biology is deciphering how chemical and mechanical signals interact within a tissue to produce organs of defined size, shape, and function. Cell walls in plants impose a unique constraint on cell expansion since cells are under turgor pressure and do not move relative to one another. Cell wall extensibility and constantly changing distribution of stress on the wall are mechanical properties that vary between individual cells and contribute to rates of expansion and orientation of cell division. Read More

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December 2018

Comparable investigation of polyaniline behavior towards gaseous ammonia and toluene adsorption.

Environ Sci Pollut Res Int 2018 Dec 14. Epub 2018 Dec 14.

Chemical and Petrochemicals Engineering Department, Egypt-Japan University of Science and Technology, New Borg El-Arab Alexandria, Egypt.

With raising awareness of gaseous air pollutants and their harmful impact, adsorption is considered one of the most prominent techniques for gaseous emissions control. The usage of polyaniline as a gas adsorbent is an innovative idea. This work aims to compare the efficacy of synthesized polyaniline nanotubes (PANT) as a novel adsorbent towards inorganic gases (ammonia NH) and volatile organic compounds (toluene vapor). Read More

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December 2018

Effectiveness of 2% Articaine as an anesthetic agent in children: randomized controlled trial.

Clin Oral Investig 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatric dentistry, Goa Dental College, Goa, Bambolim, India.

Aim: The aim of this study was to compare the effectiveness of 2% articaine and 2% lignocaine in achieving adequate anesthesia in children between the age group of 6-13 years using inferior alveolar nerve block.

Methods: A triple blinded randomized controlled trial was conducted in 180 participants (90 patients- 2% articaine, 90 patients-2% lignocaine). Effectiveness of the anesthetic agent was determined at 3 points determined by subjective evaluation of pain using pain scales (FPS-R). Read More

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December 2018

Role of a cotton endoreduplication-related gene, GaTOP6B, in response to drought stress.

Planta 2018 Dec 14. Epub 2018 Dec 14.

Zhengzhou Research Base, State Key Laboratory of Cotton Biology, Zhengzhou University, Zhengzhou, 450001, Henan, People's Republic of China.

Main Conclusion: Cotton GaTOP6B is involved in cellular endoreduplication and a positive response to drought stress via promoting plant leaf and root growth. Drought is deemed as one of adverse conditions that could cause substantial reductions in crop yields worldwide. Since cotton exhibits a moderate-tolerant phenotype under water-deficit conditions, the plant could therefore be used to characterize potential new genes regulating drought tolerance in crop plants. Read More

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December 2018
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Functional Teas from the Stems of Penthorum chinense Pursh.: Phenolic Constituents, Antioxidant and Hepatoprotective Activity.

Plant Foods Hum Nutr 2018 Dec 14. Epub 2018 Dec 14.

Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.

Penthorum chinense Pursh (PCP), a medicinal and edible plant, is traditionally used for liver protection and treatment of liver diseases. In this study, we compared the differences of composition and activity of flowers, stems and leaves of PCP to select a bioactive part. The stems of PCP with stronger antioxidant activity (6. Read More

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December 2018

Magnetic-core@dual-functional-shell nanocomposites with peroxidase mimicking properties for use in colorimetric and electrochemical sensing of hydrogen peroxide.

Mikrochim Acta 2018 Dec 14;186(1):20. Epub 2018 Dec 14.

College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China.

A self-sacrificing catalytic method is described for the preparation of magnetic core/dual-functional-shell nanocomposites composed of magnetite, gold and Prussian Blue (type FeO@Au-PB). Two reaction pathways are integrated. The first involves chemical dissolution of FeO (the self-sacrificing step) by acid to release ferrous ions which then reacts with hexacyanoferrate(IV) to generate PB in the proximity of the magntic nanoparticles (MNPs). Read More

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December 2018

Topology and ground-state degeneracy of tetrahedral smectic vesicles.

Eur Phys J E Soft Matter 2018 Dec 11;41(12):143. Epub 2018 Dec 11.

The James Franck and Enrico Fermi Institutes and The Department of Physics, The University of Chicago, 60637, Chicago, IL, USA.

Chemical design of block copolymers makes it possible to create polymer vesicles with tunable microscopic structure. Here we focus on a model of a vesicle made of smectic liquid-crystalline block copolymers at zero temperature. The vesicle assumes a faceted tetrahedral shape and the smectic layers arrange in a stack of parallel straight lines with topological defects localized at the vertices. Read More

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December 2018

Talking across the membrane.

Nat Chem 2019 Jan;11(1):18-20

Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.

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January 2019
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Application of anisotropic NMR parameters to the confirmation of molecular structure.

Nat Protoc 2018 Dec 14. Epub 2018 Dec 14.

Structure Elucidation Group, Process and Analytical Research and Development, Merck Research Laboratories, Rahway, NJ, USA.

The use of anisotropic NMR data, such as residual dipolar couplings (RDCs) and residual chemical shift anisotropies (RCSAs), has emerged as a powerful technique for structural characterization of organic small molecules. RDCs typically report the relative orientations of different H-C bonds; RCSAs report the relative orientations of different carbon chemical shielding tensors and hence are more useful for proton-deficient molecules. This information is complementary to that obtained from conventional NMR data such as J couplings, isotropic chemical shifts, and nuclear Overhauser effects (NOEs)/rotational frame nuclear Overhauser effects (ROEs). Read More

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December 2018
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