1,509,699 results match your criteria Chemical Speciation And Bioavailability[Journal]


Water soluble porphyrin as optical sensor for the toxic heavy metal ions in an aqueous medium.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 19;241:118609. Epub 2020 Jun 19.

Department of Chemistry, Faculty of Science, Kafrelsheikh University, Kafr El-Sheikh 33516, Egypt; Institute of Basic and Applied Sciences, Egypt-Japan University of Science and Technology, New Borg El-Arab, Alexandria, Egypt. Electronic address:

Here we report the photophysical and sensing properties of the aqueous solution of meso-tetra(N-methyl-4-pyridyl)porphyrin toluene sulfonate (TMPP) for simultaneous detection of toxic metal ions in an aqueous medium by using different physiochemical methods such as UV-vis absorption, steady state and time resolved fluorescence, stopped flow, and cyclic voltammetry. The steady-state absorption and fluorescence spectra in organic solvents (EtOH, DMSO, DMF, MeOH and ACN) showed the formation of monomer form (λ = 426 nm and λ = 654 and 715 nm). In THF and water, different spectral features were recorded suggested the formation of aggregated forms in both solvents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.saa.2020.118609DOI Listing

Red beet (Beta vulgaris) and amaranth (Amaranthus sp.) microgreens: Effect of storage and in vitro gastrointestinal digestion on the untargeted metabolomic profile.

Food Chem 2020 Jun 27;332:127415. Epub 2020 Jun 27.

Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, 34469 Maslak, Istanbul, Turkey.

This study aimed to investigate the combined effect of storage at 4 °C (10-days) and in vitro gastrointestinal digestion on the phytochemical profile of red beet (Beta vulgaris) and amaranth (Amaranthus sp.) microgreens. The untargeted profiling based on UHPLC-QTOF metabolomics allowed annotating 316 compounds, comprising mainly polyphenols and lipids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.foodchem.2020.127415DOI Listing

Effect of different processing methods on physicochemical properties, chemical compositions and in vitro antioxidant activities of Paeonia lactiflora Pall seed oils.

Food Chem 2020 Jun 24;332:127408. Epub 2020 Jun 24.

State Key Laboratory of Food Science and Technology, Jiangnan University, China; National Engineering Research Center for Functional Food, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, China.

A research was performed to determine and compare the physicochemical properties, chemical compositions and in vitro antioxidant activities of Paeonia lactiflora Pall seed oils with ultrasonic-assisted solvent extraction, pressing and supercritical fluid extraction. Paeonia lactiflora Pall seed oil contained a high percentage of polyunsaturated fatty acids and monounsaturated fatty acids, especially oleic (31.62-32. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.foodchem.2020.127408DOI Listing

Detection of lard in butter using Raman spectroscopy combined with chemometrics.

Food Chem 2020 Jun 15;332:127344. Epub 2020 Jun 15.

Department of Industrial Engineering, Faculty of Engineering, King Abdulaziz University, P.O. Box 80204, Jeddah 21589, Saudi Arabia.

There is a contentious need for robust and rapid methodologies for maintaining the authenticity of foods and food additives. The current paper presented a new Raman spectroscopy-based methodology for detection and quantification of lard in butter. Hierarchical cluster analysis (HCA) and principal component analysis (PCA) were successfully performed for the classification and discrimination of butter and lard-adulterated samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.foodchem.2020.127344DOI Listing

The influence of green tea extract as the steeping solution on nutritional and microbial characteristics of germinated wheat.

Food Chem 2020 Jun 9;332:127288. Epub 2020 Jun 9.

University of Gastronomic Sciences, Piazza Vittorio Emanuele 9, 12042 Pollenzo-Bra, Italy. Electronic address:

This study examined the effect of green tea extract at 10 (GWG1%) and 50 (GWG5%) g/L as the steeping solution on the chemical, nutritional, and microbial quality of wheat grain during 14 days of germination. Fat, dry matter, and ash contents in the control was higher than GWG treatments due to the faster growth of control germs. Moisture, phenolic compounds, thiamin, niacin, and tocopherols decreased, whereas, fat, dry matter, carbohydrate, protein, crude fiber, ash, folic acid, Ca, Mg, Fe, Mn, and Zn increased significantly in all samples during germination. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.foodchem.2020.127288DOI Listing

Trace element imbalances in patients undergoing chronic hemodialysis therapy - Report of an observational study in a cohort of Portuguese patients.

J Trace Elem Med Biol 2020 Jun 8;62:126580. Epub 2020 Jun 8.

Department of Environmental Health, School of Health, P.Porto, Rua Dr. António Bernardino de Almeida 400, 4200-072, Porto, Portugal.

Introduction: Patients with end-stage renal disease undergoing hemodialysis therapy are at risk of developing deficiencies of essential trace elements and/or overload of toxic trace elements, both of which may significantly affect their clinical status of. Those imbalances may result from the disease itself but also from the quality of the therapeutic process, namely the hemodialysis process, which has greatly evolved in the last decades. Thus, old observations that have been assumed as very well-proven have been recently questioned. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtemb.2020.126580DOI Listing

Measurement of selected trace elements in Olea europaea L. cv. 'Sigoise'.

Authors:
Bouzid Nedjimi

J Trace Elem Med Biol 2020 Jun 18;62:126595. Epub 2020 Jun 18.

Laboratory of Exploration and Valorization of Steppe Ecosystem, Faculty of Science of Nature and Life, Ziane Achour University of Djelfa, Cité Aîn Chih, P.O. Box 3117, Djelfa, 17000, Algeria. Electronic address:

Background: Olive-trees (Olea europaea L.) are the dominant rustic trees cultivated in the Mediterranean agricultural zones. Major and micronutrients play an indispensable role in their plant physiological functions although; the effect of trace elements on metabolic processes has not been sufficiently investigated, especially in olive-trees. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtemb.2020.126595DOI Listing

Pesticide prioritization approaches and limitations in environmental monitoring studies: From Europe to Latin America and the Caribbean.

Environ Int 2020 Jun 30;143:105917. Epub 2020 Jun 30.

Chemical Engineering and Analytical Chemistry Department, Faculty of Chemistry, Universitat de Barcelona, Martí i Franquès, 1, 08028 Barcelona, Spain.

Assessment and management of issues related to pesticide residues, such as environmental fate, monitoring and toxicity, are complex and, in many cases, require costly studies. The early establishment of a priority list of pesticides that should be monitored and assigned to a restricted-use policy is an important issue of post-registration Risk Assessment (RA). Various pesticide registration approaches have been adopted by different countries with those from Europe and the USA being the most popular, constituting the major prototypes for registration approaches in other countries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envint.2020.105917DOI Listing

What is new in the exposome?

Environ Int 2020 Jun 30;143:105887. Epub 2020 Jun 30.

MRC Centre for Environment and Health, School of Public Health, Imperial College London, Norfolk Place, W2 1PG London, UK.

The exposome concept refers to the totality of exposures from a variety of external and internal sources including chemical agents, biological agents, or radiation, from conception onward, over a complete lifetime. It encompasses also "psychosocial components" including the impact of social relations and socio-economic position on health. In this review we provide examples of recent contributions from exposome research, where we believe their application will be of the greatest value for moving forward. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envint.2020.105887DOI Listing

A divergent mode of activation of a nitrosyl iron complex with unusual antiangiogenic activity.

J Inorg Biochem 2020 Jun 20;210:111133. Epub 2020 Jun 20.

Departamento de Química Orgânica e Inorgânica, Grupo de Bioinorgânica, Universidade Federal do Ceará-UFC, P.O Box 6021, Fortaleza, CE CEP 60440-900, Brazil. Electronic address:

Nitric oxide (NO) and nitroxyl (HNO) have gained broad attention due to their roles in several physiological and pathophysiological processes. Remarkably, these sibling species can exhibit opposing effects including the promotion of angiogenic activity by NO compared to HNO, which blocks neovascularization. While many NO donors have been developed over the years, interest in HNO has led to the recent emergence of new donors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jinorgbio.2020.111133DOI Listing

Can proton-proton recoupling in fully protonated solids provide quantitative, selective and efficient polarization transfer?

J Magn Reson 2020 Jun 20;317:106777. Epub 2020 Jun 20.

TIFR Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research Hyderabad, Sy. No. 36/P, Gopanpally, Ranga Reddy District, Hyderabad 500 107, India. Electronic address:

Dipolar recoupling sequences have been used to probe spatial proximity of nuclear spins and were traditionally designed to probe rare spins such as C and/or N nuclei. The multi-spin dipolar-coupling network of the rare spins is weak due to smaller couplings and large chemical shift dispersion. Therefore, the recoupling approaches were tailored to design offset compensated or broadband sequences. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmr.2020.106777DOI Listing

Early-stage dysfunction of hippocampal theta and gamma oscillations and its modulation of neural network in a transgenic 5xFAD mouse model.

Neurobiol Aging 2020 May 12;94:121-129. Epub 2020 May 12.

College of Life Sciences, Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin, PR China. Electronic address:

Alzheimer's disease (AD) is pathologically characterized by amyloid-β (Aβ) accumulation, which induces Aβ-dependent neuronal dysfunctions. We focused on the early-stage disease progression and examined the neuronal network functioning in the 5xFAD mice. The simultaneous intracranial recordings were obtained from the hippocampal perforant path (PP) and the dentate gyrus (DG). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2020.05.002DOI Listing

The feasibility and usability of DNA-dot bioconjugation to antibody for targeted in vitro cancer cell fluorescence imaging.

J Photochem Photobiol B 2020 Jun 26;209:111944. Epub 2020 Jun 26.

Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

DNA-protein bioconjugation is an appealing target-tracking strategy. The new capability of DNA molecule as a biological nanomaterial endows unique fluorescence and physicochemical properties to be applied in bioimaging. Progression in targeted imaging is contingent on the conjugation of diagnostic nanoparticles to biomolecular signatures, particularly antibody-based ligands. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jphotobiol.2020.111944DOI Listing

Methanogenic pathway and microbial succession during start-up and stabilization of thermophilic food waste anaerobic digestion with biochar.

Bioresour Technol 2020 Jun 28;314:123751. Epub 2020 Jun 28.

Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, S117576 Singapore, Singapore; NUS Environment Research Institute, National University of Singapore, 5A Engineering Drive 1, Singapore 117411, Singapore. Electronic address:

One of the major obstacles for thermophilic anaerobic digestion is the process instability during start-up. This study proposed the use of a cost-effective additive, biochar, to accelerate and stabilize the start-up of thermophilic semi-continuous food waste anaerobic digestion. The results showed that the reactors with biochar addition resulted in up to 18% higher methane yield as compared to the control reactors (without biochar). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biortech.2020.123751DOI Listing

Sensitive detection of iron (II) sulfate with a novel reagent using spectrophotometry.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 20;240:118631. Epub 2020 Jun 20.

Istanbul Protein Research Application and Inovation Center (PROMER), Turkey; Department of Molecular Biology and Genetics, Uskudar University, 34662 Uskudar, Istanbul, Turkey. Electronic address:

In this study, a novel reagent was developed for sensitive detection of iron (II) sulfate, spectrophotometrically. A novel thio-anthraquinone derivative, 1-(Dodecylthio)anthracene-9,10-dione (3), was synthesized from the chemical reaction of 1-Chloroanthraquinone (1) and 1-Dodecanethiol (2) by an original reaction method and was used in the preparation of the novel reagent called Catal's reagent. A synthesized thio-anthraquinone analogue (3) was purified by column chromatography, and its chemical structure was characterized by spectroscopic methods such as Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), and ultraviolet (UV)-visible spectrophotometry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.saa.2020.118631DOI Listing

Distribution characteristics and comparison of chemical stabilization ways of heavy metals from MSW incineration fly ashes.

Waste Manag 2020 Jun 30;113:488-496. Epub 2020 Jun 30.

Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), College of Resources and Environment, Southwest University, Chongqing 400715, China; State Cultivation Base of Eco-agriculture for Southwest Mountainous Land, College of Resources and Environment, Southwest University, Chongqing 400715, China. Electronic address:

With the purpose of fully understanding the potential toxicity of heavy metals of various particle sizes in fly ash (FA) and finding an optimal chemical reagent stabilization scheme for fly ash with single or mixture reagents, basic physicochemical characteristics of FA was investigated using multiple chemical stabilization reagent schemes to stabilize heavy metals. The following compounds were used to develop single and mixed chemical stabilization schemes for heavy metals in waste incineration FA: sodium sulfide (NaS), sodium dihydrogen phosphate (NaHPO), ammonium dibutyl dithiophosphate (DDTP), and 2,4,6-tri-mercapto-S-triazine trisodium salt (TMT-15). The results showed that the various particle sizes of FA were mainly distributed in the range of 48-1700 μm. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wasman.2020.06.032DOI Listing

A simple and convenient electrochemiluminescence immunoassay by using gold nanoparticles as both label and co-reactant.

Bioelectrochemistry 2020 Jun 20;135:107585. Epub 2020 Jun 20.

Key Laboratory of Laser Technology and Optoelectronic Functional Materials of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.

A simple and convenient electrochemiluminescence immunoassay (ECLIA) has been developed by using gold nanoparticles (AuNPs) as both label and co-reactant. In this novel ECLIA, the detection antibodies labeled with AuNPs as co-reactant reacts directly with ruthenium complex to produce electrochemiluminescence (ECL), which avoids the weakness of luminophore as a label. The feasibility of the new method was investigated through the sandwich ECL immunosensor for the determination of human immunoglobulin (HIgG), and excitation of luminescence was respectively driven by linear sweep voltammetry and step potential. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bioelechem.2020.107585DOI Listing

Biosynthesis and tissue-specific partitioning of camphor and eugenol in Ocimum kilimandscharicum.

Phytochemistry 2020 Jun 30;177:112451. Epub 2020 Jun 30.

Division of Biochemical Sciences, CSIR-National Chemical Laboratory, Pune, 411008, Maharashtra, India. Electronic address:

In Ocimum kilimandscharicum, the relative volatile composition of camphor in leaves was as high as 55%, while that of eugenol in roots was 57%. These metabolites were differentially partitioned between the aerial and root tissues. Global metabolomics revealed tissue-specific biochemical specialization, evident by the differential distribution of 2588 putative metabolites across nine tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.phytochem.2020.112451DOI Listing

Early Neutrophil Responses to Chemical Carcinogenesis Shape Long-Term Lung Cancer Susceptibility.

iScience 2020 Jun 17;23(7):101277. Epub 2020 Jun 17.

Tumour Host Interaction Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT London, UK. Electronic address:

Neoplastic transformation causing cancer is a key problem in tumor biology and can be triggered by exposure to environmental substances. We investigated whether the cellular composition of a tissue contributes to its predisposition to cancer upon a specific carcinogen. Neutrophils are important immune components involved in cancer progression, but their contribution to generation of transformed cells is elusive. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.isci.2020.101277DOI Listing

Mitigating nutrient accumulation with microalgal growth towards enhanced nutrient removal and biomass production in an osmotic photobioreactor.

Water Res 2020 Jun 12;182:116038. Epub 2020 Jun 12.

Department of Energy, Environmental & Chemical Engineering, Washington University in St. Louis, St. Louis, Missouri, 63130, USA. Electronic address:

Forward osmosis (FO) has great potential for low energy consumption wastewater reuse provided there is no requirement for draw solutes (DS) regeneration. Reverse solute flux (RSF) can lead to DS build-up in the feed solution. This remains a key challenge because it can cause significant water flux reduction and lead to additional water quality problems. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.watres.2020.116038DOI Listing

Employing bacterial mutations for the elucidation of photo-Fenton disinfection: Focus on the intracellular and extracellular inactivation mechanisms induced by UVA and HO.

Water Res 2020 Jun 13;182:116049. Epub 2020 Jun 13.

School of Basic Sciences (SB), Institute of Chemical Science and Engineering (ISIC), Group of Advanced Oxidation Processes (GPAO), École Polytechnique Fédérale de Lausanne (EPFL), Station 6, CH-1015, Lausanne, Switzerland. Electronic address:

The bacterial inactivation mechanisms by solar light and the photo-Fenton process is still a matter of debate. In this study, we bring evidence towards the elucidation of the mechanisms that govern photo-Fenton disinfection at near-neutral pH. With the use of porin-deficient and catalase over-producing E. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.watres.2020.116049DOI Listing

Dual-frequency ultrasound: Strengths and shortcomings to water treatment and disinfection.

Water Res 2020 Jun 8;182:116016. Epub 2020 Jun 8.

Laboratory of Engineering Ecology, Baikal Institute of Nature Management, Siberian Branch of Russian Academy of Sciences, Ulan-Ude, Russia.

Since the early 2000s, dual-frequency ultrasound (DFUS) has received much attention for synergistically enhanced elimination of organic pollutants and pathogenic microorganisms from water. In the present review, we have surveyed recent developments in acoustic physics to elucidate the mechanism of synergistic effect under exposure of aqueous media to DFUS. Briefly, the nonlinear dynamics of microbubbles upon DFUS exposure produces additional frequencies, such as harmonics, subharmonics, ultraharmonics and combination frequencies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.watres.2020.116016DOI Listing

Isolation, purification, and structural characterization of polysaccharides from Atractylodis Macrocephalae Rhizoma and their immunostimulatory activity in RAW264.7 cells.

Int J Biol Macromol 2020 Jun 30. Epub 2020 Jun 30.

Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnosis, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China. Electronic address:

Three water-soluble polysaccharides (AMAP-1, AMAP-2 and AMAP-3) were isolated and purified from Atractylodis Macrocephalae Rhizoma by using the combination of ion-exchange chromatography and gel permeation chromatography. The structures of the polysaccharides were characterized by chemical derivatization, HPGC, GC-MS, FT-IR, and NMR techniques. Structural analyses show that the three polysaccharides are pectin-type macromolecules consisting of homogalacturonan (HG) and rhamnogalacturonan type I (RG-I) regions in different ratios. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2020.06.269DOI Listing

Agrochemicals and obesity.

Mol Cell Endocrinol 2020 Jun 30:110926. Epub 2020 Jun 30.

Department of Developmental and Cell Biology, University of California, Irvine, CA, 92697-2300, USA; Department of Pharmaceutical Sciences, University of California, Irvine, CA, USA; Department of Biomedical Engineering, University of California, Irvine, CA, USA. Electronic address:

Obesity has become a very large concern worldwide, reaching pandemic proportions over the past several decades. Lifestyle factors, such as excess caloric intake and decreased physical activity, together with genetic predispositions, are well-known factors related to obesity. There is accumulating evidence suggesting that exposure to some environmental chemicals during critical windows of development may contribute to the rapid increase in the incidence of obesity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mce.2020.110926DOI Listing

Adolescent oxytocin treatment affects resident behavior in aggressive but not tame adult rats.

Physiol Behav 2020 Jun 30:113046. Epub 2020 Jun 30.

Institute of Cytology and Genetics, Novosibirsk, Russia. Electronic address:

There are indications that exposing adolescent rodents to oxytocin (OT) promotes social activity and reduces anxiety in adulthood. Adult male gray rats selected for elimination and enhancement of the aggressive response to humans, when exposed to OT, showed divergent changes in the resident behavior towards the intruder. It could be assumed that adolescent administration of both OT and antagonist of OT receptor (OTR) would also have different long-term effects on resident behavior and startle reflex in adult aggressive and tame rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.physbeh.2020.113046DOI Listing

Phenformin promotes keratinocyte differentiation via the calcineurin/NFAT pathway.

J Invest Dermatol 2020 Jun 30. Epub 2020 Jun 30.

Department of Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China; Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

Phenformin is a drug in the biguanide class that was previously used to treat type 2 diabetes. We have reported the anti-tumor activities of phenformin to enhance the efficacy of BRAF-MEK-ERK pathway inhibition and to inhibit myeloid-derived suppressor cells in various melanoma models. Here we demonstrate that phenformin suppresses tumor growth and promotes keratinocyte differentiation in the DMBA/TPA two stage skin carcinogenesis mouse model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jid.2020.05.114DOI Listing

What CHO is made of: Variations in the biomass composition of Chinese hamster ovary cell lines.

Metab Eng 2020 Jun 30. Epub 2020 Jun 30.

Acib - Austrian Centre of Industrial Biotechnology, 1190, Vienna, Austria, EU; Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, 1190, Vienna, Austria, EU; Department of Analytical Chemistry, University of Vienna, 1010, Vienna, Austria, EU. Electronic address:

Background: Cell line-specific, genome-scale metabolic models enable rigorous and systematic in silico investigation of cellular metabolism. Such models have recently become available for Chinese hamster ovary (CHO) cells. However, a key ingredient, namely an experimentally validated biomass function that summarizes the cellular composition, was so far missing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymben.2020.06.002DOI Listing

Thiosulfinate Tolerance Is a Virulence Strategy of an Atypical Bacterial Pathogen of Onion.

Curr Biol 2020 Jun 26. Epub 2020 Jun 26.

University of Georgia, Department of Plant Biology, Carleton St., Athens, GA 30602, USA; University of Georgia, The Plant Center, Carleton St., Athens, 30602, Athens, GA 30602, USA. Electronic address:

Unlike most characterized bacterial plant pathogens, the broad-host-range plant pathogen Pantoea ananatis lacks both the virulence-associated type III and type II secretion systems. In the absence of these typical pathogenicity factors, P. ananatis induces necrotic symptoms and extensive cell death in onion tissue dependent on the HiVir proposed secondary metabolite synthesis gene cluster. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cub.2020.05.092DOI Listing

Regulatory roles of metabotropic glutamate receptors on synaptic communication mediated by gap junctions.

Neuroscience 2020 Jun 30. Epub 2020 Jun 30.

Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA. Electronic address:

Variations of synaptic strength are thought to underlie forms of learning and can functionally reshape neural circuits. Metabotropic glutamate receptors play key roles in regulating the strength of chemical synapses. However, information within neural circuits is also conveyed via a second modality of transmission: gap junction-mediated synapses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroscience.2020.06.034DOI Listing

Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent.

Mol Cell 2020 Jul;79(1):191-198.e3

Department of Cellular & Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Center for RNA Systems Biology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

We recently used CRISPRi/a-based chemical-genetic screens and cell biological, biochemical, and structural assays to determine that rigosertib, an anti-cancer agent in phase III clinical trials, kills cancer cells by destabilizing microtubules. Reddy and co-workers (Baker et al., 2020, this issue of Molecular Cell) suggest that a contaminating degradation product in commercial formulations of rigosertib is responsible for the microtubule-destabilizing activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2020.06.008DOI Listing

Differential distribution of characteristic constituents in root, stem and leaf tissues of Salvia miltiorrhiza using MALDI mass spectrometry imaging.

Fitoterapia 2020 Jun 30:104679. Epub 2020 Jun 30.

Natural Product Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address:

Segmentation-quantification is the most commonly used method for studying the tissue distribution of bioactive constituents in plant, but this method would bring uncontrollable pollution, compound migration and denaturation. Mass spectrometry imaging (MSI), as a new method developed in the past 20 years, has high sensitivity, high spatial resolution, high degree of visualization, and low risk of contamination and degeneration when studying tissue distribution of compounds. For the first time we applied matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) to tissue distribution of characteristic constituents of the medicinal plant Salvia miltiorrhiza. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2020.104679DOI Listing

A Systematic Analysis of Mosquito-Microbiome Biosynthetic Gene Clusters Reveals Antimalarial Siderophores that Reduce Mosquito Reproduction Capacity.

Cell Chem Biol 2020 Jun 29. Epub 2020 Jun 29.

Department of Chemistry, Duke University, Durham, NC, USA; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA. Electronic address:

Advances in infectious disease control strategies through genetic manipulation of insect microbiomes have heightened interest in microbially produced small molecules within mosquitoes. Herein, 33 mosquito-associated bacterial genomes were mined and over 700 putative biosynthetic gene clusters (BGCs) were identified, 135 of which belong to known classes of BGCs. After an in-depth analysis of the 135 BGCs, iron-binding siderophores were chosen for further investigation due to their high abundance and well-characterized bioactivities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chembiol.2020.06.004DOI Listing

Profiling Substrate Promiscuity of Wild-Type Sugar Kinases for Multi-fluorinated Monosaccharides.

Cell Chem Biol 2020 Jun 30. Epub 2020 Jun 30.

Department of Chemistry, University of York, Heslington, York YO10 5DD, UK. Electronic address:

Fluorinated sugar-1-phosphates are of emerging importance as intermediates in the chemical and biocatalytic synthesis of modified oligosaccharides, as well as probes for chemical biology. Here we present a systematic study of the activity of a wide range of anomeric sugar kinases (galacto- and N-acetylhexosamine kinases) against a panel of fluorinated monosaccharides, leading to the first examples of polyfluorinated substrates accepted by this class of enzymes. We have discovered four new N-acetylhexosamine kinases with a different substrate scope, thus expanding the number of homologs available in this subclass of kinases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chembiol.2020.06.005DOI Listing

Convergent Evolution in Breadth of Two V6-1-Encoded Influenza Antibody Clonotypes from a Single Donor.

Cell Host Microbe 2020 Jun 29. Epub 2020 Jun 29.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, San Diego, CA 92037, USA; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, San Diego, CA 92037, USA. Electronic address:

Understanding how broadly neutralizing antibodies (bnAbs) to influenza hemagglutinin (HA) naturally develop in humans is critical to the design of universal influenza vaccines. Several classes of bnAbs directed to the conserved HA stem were found in multiple individuals, including one encoded by heavy-chain variable domain V6-1. We describe two genetically similar V6-1 bnAb clonotypes from the same individual that exhibit different developmental paths toward broad neutralization activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chom.2020.06.003DOI Listing

Application of birnessite-type solids prepared by sol-gel and oxidation methods in photocatalytic degradation of 4-nitrophenol.

Environ Technol 2020 Jul 3:1-16. Epub 2020 Jul 3.

INAMAT-Departamento de Ciencias, Universidad Pública de Navarra, Pamplona, Spain.

Potassium birnessites were prepared using two methods, sol-gel or oxidation. The solids were characterized by element chemical analysis, powder X-ray diffraction, FTIR spectroscopy, thermal analyses, and nitrogen adsorption. The evolution of the properties as a function of the preparation method was discussed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09593330.2020.1791968DOI Listing

Lignans from linseed ( L.) and its allied species: Retrospect, introspect and prospect.

Crit Rev Food Sci Nutr 2020 Jul 3:1-23. Epub 2020 Jul 3.

Department of Botany, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India.

Lignans are complex diphenolic compounds representing phytoestrogens and occur widely across the plant kingdom. Formed by the coupling of two coniferyl alcohol residues, lignans constitute major plant "specialized metabolites" with exceptional biological attributes that aid in plant defence and provide health benefits in humans by reducing the risk of ailments such as cancer, diabetes etc. Linseed ( L. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10408398.2020.1784840DOI Listing

A Critical Review on Application of Extraction Methods Prior to Spectrometric Determination of Trace-Metals in Oily Matrices.

Crit Rev Anal Chem 2020 Jul 3:1-18. Epub 2020 Jul 3.

Department of Chemistry, College of Science and Engineering and Technology, University of South Africa, Johannesburg, South Africa.

The presence of heavy metals in oily matrices (edible oils or crude-oil and its derivatives) cannot be controlled or prevented as they occur naturally during oil genesis. However, the presence of these metal ions in oils has negative effects, because some metal ions can act as catalyst poisons, refinery corroders and environmental pollutants during refinery processes. Additionally, some metal ions have negative health impacts when consumed by living organisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10408347.2020.1781591DOI Listing

Application of artificial neural networks to prediction of new substances with antimicrobial activity against Escherichia coli.

J Appl Microbiol 2020 Jul 3. Epub 2020 Jul 3.

Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Faculty of Pharmacy, Department of Biopharmacy, Jurasza, 85-791, Bydgoszcz, Poland.

Aims: This article presents models of artificial neural networks employed to predict the biological activity of chemical compounds based of their structure. Regression and classification models were designed to determine antimicrobial properties of quaternary ammonium salts against Escherichia coli strain.

Methods And Results: The minimum inhibitory concentration (MIC) microbial growth Escherichia coli was experimentally determined by the serial dilution method for a series of 140 imidazole derivatives. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jam.14763DOI Listing

Charge-Separated and Lewis Paired Metal-Organic Framework for Anion Exchange and CO2 Chemical Fixation.

Chemistry 2020 Jul 3. Epub 2020 Jul 3.

University of New Mexico, Department of Chemistry and Chemical Biology, MSC03 2060, 1 UNM, 87131, Albuquerque, UNITED STATES.

Charge-separated metal-organic frameworks (MOFs) are a unique class of MOFs that can possess added properties originating from the exposed ionic species. We report a new charge-separated MOF, namely UNM-6, synthesized from a tetrahedral borate ligand and Co 2+ cation. UNM-6 crystalizes into the highly symmetric P-43n space group with four-fold interpenetration, despite the stoichiometric imbalance between the B and Co atoms, which also leads to loosely bound NO 3 - anions within the crystal structure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/chem.202002823DOI Listing

Surface and structural changes in root dentin by various chelating solutions used in regenerative endodontics.

Int Endod J 2020 Jul 3. Epub 2020 Jul 3.

Division of Endodontics, Buffalo, NY, USA.

Aim: To evaluate the effects of the prolonged use of various irrigant solutions used in regenerative endodontic procedures on the physical and chemical structure of root canal dentine in extracted human teeth.

Methodology: Sixty-root dentine samples from extracted, single-rooted, human teeth were assigned to 10 groups. 8 groups were irrigated with 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/iej.13354DOI Listing

Ligand Regulated Regiodivergent Hydrosilylation of Isoprene under Iron Catalysis.

Angew Chem Int Ed Engl 2020 Jul 3. Epub 2020 Jul 3.

Chinese Academy of Sciences, Dalian Institute of Chemical Physics, 457 Zhongshan Road, 116023, Dalian, CHINA.

A regiodivergent and stereoselective hydrosilylation of basic industrial feedstock isoprene with unactivated silanes has been developed using earth-abundant iron catalyst. The manipulation of regioselectivity relies on fine modification of the coordination geometry of iron center. While a bidentate pyridine imine ligand promotes the formation of allylic silanes via a 4,1-addition, the selectivity toward 3,4-adduct homoallylic silanes was achieved by switching to tridentate nitrogen ligand. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.202007930DOI Listing

Role of CPEB3 protein in learning and memory: new insights from synaptic plasticity.

Aging (Albany NY) 2020 Jul 2;12. Epub 2020 Jul 2.

Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, China.

The cytoplasmic polyadenylation element-binding (CPEB) protein family have demonstrated a crucial role for establishing synaptic plasticity and memory in model organisms. In this review, we outline evidence for CPEB3 as a crucial regulator of learning and memory, citing evidence from behavioral, electrophysiological and morphological studies. Subsequently, the regulatory role of CPEB3 is addressed in the context of the plasticity-related proteins, including AMPA and NMDA receptor subunits, actin, and the synaptic scaffolding protein PSD95. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.103404DOI Listing

Screening of drug efficacy of Rosmarinic Acid derivatives as Aurora kinase inhibitors by computer aided drug design method.

Curr Comput Aided Drug Des 2020 Jul 3. Epub 2020 Jul 3.

Department of Chemistry, University of North Bengal, Darjeeling, West Bengal, 734013. India.

Background: Aurora kinases (AKs) belong to serine/threonine kinase family, play a crucial role in regulating the cell cycle. Therefore, AKs are the hopeful target for anticancer therapies and these finding have appreciated researchers to rigorous hunting of small molecule aurora kinase inhibitors, not only for research articles but also use as therapeutic agent.

Objective: The present study helps us to identify and screen best phytochemicals as potent inhibitors against AKs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1573409916666200703170045DOI Listing

Changes in symmetry during gait in adults with Prader-Willi syndrome.

Comput Methods Biomech Biomed Engin 2020 Jul 3:1-8. Epub 2020 Jul 3.

Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy.

Most studies on locomotion of individuals with the Prader-Willi Syndrome (PWS) have been performed in a laboratory setting using quantitative motion analysis. Recently, wireless inertial sensors have been successfully employed for gait analysis in different pathological states with the advantages of reproducing a testing condition very close to those encountered in daily living. Using such devices, it is possible not only to characterize the conventional spatio-temporal parameters, but also extract information on further less conventional metrics, such as the harmonic ratio (HR), a measure of step-to-step symmetry based on trunk acceleration processing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10255842.2020.1787999DOI Listing

Release Mechanisms and Applications of Drug Delivery Systems for Extended-Release.

Expert Opin Drug Deliv 2020 Jul 3. Epub 2020 Jul 3.

Department of Industrial and Manufacturing Systems Engineering, Biomedical Engineering Programme, Chemical Biology Centre, and Li Ka Shing Faculty of Medicine, The University of Hong Kong , Pokfulam, HKSAR, China.

Introduction: Drug delivery systems with extended-release profiles are ideal in improving patient compliance with enhanced efficacy. To develop devices capable of a prolonged delivery kinetics, it is crucial to understand the various underlying mechanisms contributing to extended drug release and the impact thereof on modulating the long-term performance of such systems in a practical application environment.

Areas Covered: This review article intends to provide a comprehensive summary of release mechanisms in extended-release drug delivery systems, particularly polymer-based systems; however, other material types will also be mentioned. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17425247.2020.1788541DOI Listing

Formulation development of paracetamol instant jelly for paediatric use.

Drug Dev Ind Pharm 2020 Jul 3:1-30. Epub 2020 Jul 3.

Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan, 25200, Malaysia.

Objective: Paracetamol is a common antipyretic and analgesic medicine used in childhood illness by parents and physicians worldwide. Paracetamol has a bitter taste that is considered as a significant barrier for drug administration. This study aimed to develop an oral dosage form that is palatable and easy to swallow by paediatric patients as well as to overcome the shortcomings of liquid formulations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/03639045.2020.1791165DOI Listing

A new indole alkaloid from the stems of var.

Nat Prod Res 2020 Jul 3:1-6. Epub 2020 Jul 3.

School of Chemistry and Chemical Engineering, Key Laboratory of Clean Energy Materials Chemistry of Guangdong Higher Education Institutes, Lingnan Normal University, Zhanjiang, P. R. China.

A phytochemical investigation on the stems of var. led to the isolation of a new indole alkaloid (named glycosmiscrol A, ), together with four known compounds (-). The new structure was elucidated by detailed analysis of comprehensive spectroscopic methods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14786419.2020.1788024DOI Listing

Suppressing Molecular Charging, Nano-Chemistry, and Optical Rectification in the Tip-Enhanced Raman Geometry.

J Phys Chem Lett 2020 Jul 3. Epub 2020 Jul 3.

Classical vs quantum plasmons are operative in tapping vs contact mode tip-enhanced Raman scattering (TERS) and lead to distinct observables. Under otherwise identical experimental conditions, we illustrate the concept through tapping and contact mode TERS mapping of chemically functionalized silver nanocubes. Whereas molecular charging, chemical transformations, and optical rectification are prominent observables in contact mode TERS, the same effects are suppressed using tapping mode feedback. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jpclett.0c01413DOI Listing

Toxicity of Nanoparticulate Nickel to Aquatic Organisms: Review and Recommendations for Improvement of Toxicity Tests.

Environ Toxicol Chem 2020 Jul 3. Epub 2020 Jul 3.

NiPERA Inc., 2525 Meridian Parkway, Suite 240, Durham, NC, 27713 USA.

We review the literature on toxicity of nanoparticulate nickel (nano-Ni) to aquatic organisms, from the perspective of relevance and reliability in a regulatory framework. Our main findings are (1) much of the published nano-Ni toxicity data is of low or medium quality in terms of reporting key physical-chemical properties, methodologies, and results, compared to published dissolved nickel studies, and (2) based on available information, some common findings about nanoparticle toxicity are not supported for nano-Ni. First, we conclude that nanoparticulate elemental nickel and nickel oxide, which differ in chemical composition, generally did not differ in their toxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/etc.4812DOI Listing

Unravelling the role of water in ultrafast excited-state relaxation dynamics within nano-architectures of Chlorophyll a.

Chemphyschem 2020 Jul 3. Epub 2020 Jul 3.

Indian Institute of Science Education and Research Mohali, Chemical Sciences, INDIA.

Water plays a pivotal role in structural stability of supramolecular pigment assemblies designed for natural light harvesting (for example, chlorosome antenna complex) as well as their artificial analogs. However, the dynamic role of water in the context of excite-state relaxation has not been explored till date, which we report here. Using femtosecond transient absorption spectroscopy, here we investigate the excited state dynamics of two types of nano-scale assemblies of chlorophyll-a having different structural motifs, rod-shaped and micellar assemblies, that depends on the water content. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cphc.202000487DOI Listing
  • Page 1 of 30194