4,516 results match your criteria Chemical Reviews [Journal]


Developing and Testing of Lipid Force Fields with Applications to Modeling Cellular Membranes.

Chem Rev 2019 Feb 20. Epub 2019 Feb 20.

The amphipathic nature of the lipid molecule (hydrophilic head and hydrophobic tails) enables it to act as a barrier between fluids with various properties and to sustain an environment where the processes critical to life may proceed. While computer simulations of biomolecules primarily investigate protein conformation and binding to drug-like molecules, these interactions often occur in the context of a lipid membrane. Chemical specificity of lipid models is essential to accurately represent the complex environment of the lipid membrane. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00384DOI Listing
February 2019

Transition Metal Vinylidene- and Allenylidene-Mediated Catalysis in Organic Synthesis.

Chem Rev 2019 Feb 15. Epub 2019 Feb 15.

Department of Chemistry , Seoul National University , Seoul 08826 , Republic of Korea.

With their mechanistic novelty and various modalities of reactivity, transition metal unsaturated carbene (alkenylidene) complexes have emerged as versatile intermediates for new reaction discovery. In particular, the past decade has witnessed remarkable advances in the chemistry of metal vinylidenes and allenylidenes, leading to the evolution of a diverse array of new catalytic transformations that are mechanistically distinct from those developed in the previous two decades. This review aims to provide a survey of the recent achievements in the development of organic reactions that make use of transition metal alkenylidenes as catalytic intermediates and their applications to organic synthesis. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00568DOI Listing
February 2019

Electro- and Solar-Driven Fuel Synthesis with First Row Transition Metal Complexes.

Chem Rev 2019 Feb 15. Epub 2019 Feb 15.

Christian Doppler Laboratory for Sustainable SynGas Chemistry, Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , United Kingdom.

The synthesis of renewable fuels from abundant water or the greenhouse gas CO is a major step toward creating sustainable and scalable energy storage technologies. In the last few decades, much attention has focused on the development of nonprecious metal-based catalysts and, in more recent years, their integration in solid-state support materials and devices that operate in water. This review surveys the literature on 3d metal-based molecular catalysts and focuses on their immobilization on heterogeneous solid-state supports for electro-, photo-, and photoelectrocatalytic synthesis of fuels in aqueous media. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00392DOI Listing
February 2019

Cocatalysts for Selective Photoreduction of CO into Solar Fuels.

Chem Rev 2019 Feb 14. Epub 2019 Feb 14.

Department of Chemistry , University of Missouri-Kansas City , Kansas City , Missouri 64110 , United States.

Photoreduction of CO into sustainable and green solar fuels is generally believed to be an appealing solution to simultaneously overcome both environmental problems and energy crisis. The low selectivity of challenging multi-electron CO photoreduction reactions makes it one of the holy grails in heterogeneous photocatalysis. This Review highlights the important roles of cocatalysts in selective photocatalytic CO reduction into solar fuels using semiconductor catalysts. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00400DOI Listing
February 2019
1 Read

Metal Halide Perovskite Nanocrystals: Synthesis, Post-Synthesis Modifications, and Their Optical Properties.

Chem Rev 2019 Feb 13. Epub 2019 Feb 13.

Nanochemistry Department , Istituto Italiano di Tecnologia , Via Morego 30 , 16163 Genova , Italy.

Metal halide perovskites represent a flourishing area of research, which is driven by both their potential application in photovoltaics and optoelectronics and by the fundamental science behind their unique optoelectronic properties. The emergence of new colloidal methods for the synthesis of halide perovskite nanocrystals, as well as the interesting characteristics of this new type of material, has attracted the attention of many researchers. This review aims to provide an up-to-date survey of this fast-moving field and will mainly focus on the different colloidal synthesis approaches that have been developed. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00644DOI Listing
February 2019

Emerging Diversity in Lipid-Protein Interactions.

Chem Rev 2019 Feb 13. Epub 2019 Feb 13.

Centre for Molecular Simulation and Department of Biological Sciences , University of Calgary , 2500 University Drive NW , Calgary , Alberta T2N 1N4 , Canada.

Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable membrane environment for proteins to being embedded in to detailed roles in complicated and well-regulated protein functions. Experimental and computational advances are converging in a rapidly expanding research area of lipid-protein interactions. Experimentally, the database of high-resolution membrane protein structures is growing, as are capabilities to identify the complex lipid composition of different membranes, to probe the challenging time and length scales of lipid-protein interactions, and to link lipid-protein interactions to protein function in a variety of proteins. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00451DOI Listing
February 2019

Annual Editorial for Chemical Reviews.

Chem Rev 2019 Feb;119(3):1625

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http://dx.doi.org/10.1021/acs.chemrev.9b00015DOI Listing
February 2019

Biological Membrane Organization and Cellular Signaling.

Chem Rev 2019 Feb 12. Epub 2019 Feb 12.

UT/ORNL Center for Molecular Biophysics, Biosciences Division , Oak Ridge National Laboratory , Oak Ridge , Tennessee 37831-6309 , United States.

To execute their many vital functions, cell membranes are highly organized. Here, we review how membrane structure shapes signal transduction across membranes. Recent experimental and computational advances have shed significant light on mechanisms linking the function of membrane signaling proteins to the composition and physical properties of the membrane lateral structures in which they are embedded. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00439DOI Listing
February 2019

Prevalence of Diarylprolinol Silyl Ethers as Catalysts in Total Synthesis and Patents.

Chem Rev 2019 Feb 12. Epub 2019 Feb 12.

Department of Chemistry , Aarhus University , DK-8000 Aarhus C , Denmark.

Diarylprolinol silyl ethers are among the most utilized stereoselective organocatalysts for the construction of complex molecules. With their debut in 2005, these catalysts have been applied in numerous method developments primarily leveraging enamine and iminium-ion catalysis. These strategies have extended into the preparation of complex molecules in both academic and industrial settings. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00583DOI Listing
February 2019

Molecular Dynamics Simulations of Membrane Permeability.

Chem Rev 2019 Feb 12. Epub 2019 Feb 12.

Laboratory of Computational Biology, National Lung, Heart, and Blood Institute , National Institutes of Health , Bethesda , Maryland 20892 , United States.

This Review illustrates the evaluation of permeability of lipid membranes from molecular dynamics (MD) simulation primarily using water and oxygen as examples. Membrane entrance, translocation, and exit of these simple permeants (one hydrophilic and one hydrophobic) can be simulated by conventional MD, and permeabilities can be evaluated directly by Fick's First Law, transition rates, and a global Bayesian analysis of the inhomogeneous solubility-diffusion model. The assorted results, many of which are applicable to simulations of nonbiological membranes, highlight the limitations of the homogeneous solubility diffusion model; support the utility of inhomogeneous solubility diffusion and compartmental models; underscore the need for comparison with experiment for both simple solvent systems (such as water/hexadecane) and well-characterized membranes; and demonstrate the need for microsecond simulations for even simple permeants like water and oxygen. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00486DOI Listing
February 2019

Pulse Radiolysis Studies for Mechanism in Biochemical Redox Reactions.

Authors:
Kazuo Kobayashi

Chem Rev 2019 Feb 11. Epub 2019 Feb 11.

The Institute of Scientific and Industrial Research , Osaka University , Mihogaoka 8-1 , Ibaraki , Osaka 567-0047 , Japan.

Pulse radiolysis is a powerful method for generating highly reduced or oxidized species and free radicals. Combined with fast time-resolved spectroscopic measurement, we can monitor the reactions of intermediate species on time scales ranging from picoseconds to seconds. The application of pulse radiolysis to water generates hydrated electrons (e) and specific radicals, rendering this technique useful for investigating a number of biological redox processes. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00405DOI Listing
February 2019

Structural Simplification of Natural Products.

Chem Rev 2019 Feb 7. Epub 2019 Feb 7.

Department of Medicinal Chemistry, School of Pharmacy , Second Military Medical University , 325 Guohe Road , Shanghai , 200433 , P.R. China.

Natural products (NPs) are important sources of clinical drugs due to their structural diversity and biological prevalidation. However, the structural complexity of NPs leads to synthetic difficulties, unfavorable pharmacokinetic profiles, and poor drug-likeness. Structural simplification by truncating unnecessary substructures is a powerful strategy for overcoming these limitations and improving the efficiency and success rate of NP-based drug development. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00504DOI Listing
February 2019

Triplet Pair States in Singlet Fission.

Chem Rev 2019 Feb 5. Epub 2019 Feb 5.

Department of Chemistry , Columbia University , New York , New York 10027 , United States.

This account aims at providing an understanding of singlet fission, i.e., the photophysical process of a singlet state ( S) splitting into two triplet states (2 × T) in molecular chromophores. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00572DOI Listing
February 2019

Singlet Molecular Oxygen Reactions with Nucleic Acids, Lipids, and Proteins.

Chem Rev 2019 Feb 5;119(3):2043-2086. Epub 2019 Feb 5.

Département de Médecine Nucléaire et Radiobiologie, Faculté de Médecine des Sciences de la Santé , Université de Sherbrooke , Sherbrooke , J1H 5N4 Québec , Canada.

Singlet oxygen (O) is a biologically relevant reactive oxygen species capable of efficiently reacting with cellular constituents. The resulting oxidatively generated damage to nucleic acids, membrane unsaturated lipids, and protein components has been shown to be implicated in several diseases, including arthritis, cataracts, and skin cancer. Singlet oxygen may be endogenously produced, among various possibilities, by myeloperoxidase, an enzyme implicated in inflammation processes, and also efficiently in skin by the UVA component of solar radiation through photosensitization reactions. Read More

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http://pubs.acs.org/doi/10.1021/acs.chemrev.8b00554
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http://dx.doi.org/10.1021/acs.chemrev.8b00554DOI Listing
February 2019
2 Reads

Chemistries for DNA Nanotechnology.

Chem Rev 2019 Feb 4. Epub 2019 Feb 4.

Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry , Aarhus University , Gustav Wieds Vej 14 , DK - 8000 Aarhus C, Denmark.

The predictable nature of DNA interactions enables the programmable assembly of highly advanced 2D and 3D DNA structures of nanoscale dimensions. The access to ever larger and more complex structures has been achieved through decades of work on developing structural design principles. Concurrently, an increased focus has emerged on the applications of DNA nanostructures. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00570DOI Listing
February 2019

Principles and Applications of Nucleic Acid Strand Displacement Reactions.

Chem Rev 2019 Feb 4. Epub 2019 Feb 4.

Physics Department , TU München , 85748 Garching , Germany.

Dynamic DNA nanotechnology, a subfield of DNA nanotechnology, is concerned with the study and application of nucleic acid strand-displacement reactions. Strand-displacement reactions generally proceed by three-way or four-way branch migration and initially were investigated for their relevance to genetic recombination. Through the use of toeholds, which are single-stranded segments of DNA to which an invader strand can bind to initiate branch migration, the rate with which strand displacement reactions proceed can be varied by more than 6 orders of magnitude. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00580DOI Listing
February 2019

Tetrazoles via Multicomponent Reactions.

Chem Rev 2019 Feb 1;119(3):1970-2042. Epub 2019 Feb 1.

Drug Design Group, Department of Pharmacy , University of Groningen , Antonius Deusinglaan 1 , 9700 AD Groningen , The Netherlands.

Tetrazole derivatives are a prime class of heterocycles, very important to medicinal chemistry and drug design due to not only their bioisosterism to carboxylic acid and amide moieties but also to their metabolic stability and other beneficial physicochemical properties. Although more than 20 FDA-approved drugs contain 1 H- or 2 H-tetrazole substituents, their exact binding mode, structural biology, 3D conformations, and in general their chemical behavior is not fully understood. Importantly, multicomponent reaction (MCR) chemistry offers convergent access to multiple tetrazole scaffolds providing the three important elements of novelty, diversity, and complexity, yet MCR pathways to tetrazoles are far from completely explored. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376451PMC
February 2019

Nonclassical Applications of closo-Carborane Anions: From Main Group Chemistry and Catalysis to Energy Storage.

Chem Rev 2019 Feb 1. Epub 2019 Feb 1.

Department of Chemistry , University of California, Riverside , 501 Big Springs Road , Riverside , California 92521 , United States.

Classically closo-carborane anions, particularly [HCBH] and [HCBH], and their derivatives have primarily been used as weakly coordinating anions to isolate reactive intermediates, platforms for stoichiometric and catalytic functionalization, counteranions for simple Lewis acid catalysis, and components of materials like liquid crystals. The aim of this article is to educate the reader on the contemporary nonclassical applications of these anions. Specifically, this review will cover new directions in main group catalysis utilized to achieve some of the most challenging catalytic reactions such as C-F, C-H, and C-C functionalizations that are difficult or impossible to realize with transition metals. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00551DOI Listing
February 2019

Copper-Promoted Functionalization of Organic Molecules: from Biologically Relevant Cu/O Model Systems to Organometallic Transformations.

Chem Rev 2019 Jan 30. Epub 2019 Jan 30.

Department of Chemistry , Southern Methodist University , Dallas , Texas 75275 , United States.

Copper is one of the most abundant and less toxic transition metals. Nature takes advantage of the bioavailability and rich redox chemistry of Cu to carry out oxygenase and oxidase organic transformations using O (or HO) as oxidant. Inspired by the reactivity of these Cu-dependent metalloenzymes, chemists have developed synthetic protocols to functionalize organic molecules under enviormentally benign conditions. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00368DOI Listing
January 2019

Utility of B-Factors in Protein Science: Interpreting Rigidity, Flexibility, and Internal Motion and Engineering Thermostability.

Chem Rev 2019 Feb 30;119(3):1626-1665. Epub 2019 Jan 30.

Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences , 32 West Seventh Avenue, Tianjin Airport Economic Area , Tianjin 300308 , China.

The term B-factor, sometimes called the Debye-Waller factor, temperature factor, or atomic displacement parameter, is used in protein crystallography to describe the attenuation of X-ray or neutron scattering caused by thermal motion. This review begins with analyses of early protein studies which suggested that B-factors, available from the Protein Data Bank, can be used to identify the flexibility of atoms, side chains, or even whole regions. This requires a technique for obtaining normalized B-factors. Read More

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http://pubs.acs.org/doi/10.1021/acs.chemrev.8b00290
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http://dx.doi.org/10.1021/acs.chemrev.8b00290DOI Listing
February 2019
10 Reads

Polytetrafluoroethylene: Synthesis and Characterization of the Original Extreme Polymer.

Chem Rev 2019 Feb 28;119(3):1763-1805. Epub 2019 Jan 28.

Ingenierie et Architectures Macromoléculaires , Institut Charles Gerhardt , UMR 5253 CNRS, UM, ENSCM, Place Eugène Bataillon , 34095 Montpellier , Cedex 5 , France.

This Review aims to be a comprehensive, authoritative, and critical review of general interest to the chemistry community (both academia and industry) as it contains an extensive overview of all published data on the homopolymerization of tetrafluoroethylene (TFE), detailing the TFE homopolymerization process and the resulting chemical and physical properties. Several reviews and encyclopedia chapters on the properties and applications of fluoropolymers in general have been published, including various reviews that extensively report copolymers of TFE (listed below). Despite this, a thorough review of the specific methods of synthesis of the homopolymer, and the relationships between synthesis conditions and the physicochemical properties of the material prepared, has not been available. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00458DOI Listing
February 2019

Tuning the Luminescence of Layered Halide Perovskites.

Chem Rev 2019 Jan 28. Epub 2019 Jan 28.

Department of Chemistry , Stanford University , Stanford , California 94305 , United States.

Layered halide perovskites offer a versatile platform for manipulating light through synthetic design. Although most layered perovskites absorb strongly in the ultraviolet (UV) or near-UV region, their emission can range from the UV to the infrared region of the electromagnetic spectrum. This emission can be very narrow, displaying high color purity, or it can be extremely broad, spanning the entire visible spectrum and providing high color rendition (or accurately reproducing illuminated colors). Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00477DOI Listing
January 2019

Bio-Integrated Wearable Systems: A Comprehensive Review.

Chem Rev 2019 Jan 28. Epub 2019 Jan 28.

Northwestern University , 2145 Sheridan Road , Evanston , Illinois 60208 , United States.

Bio-integrated wearable systems can measure a broad range of biophysical, biochemical, and environmental signals to provide critical insights into overall health status and to quantify human performance. Recent advances in material science, chemical analysis techniques, device designs, and assembly methods form the foundations for a uniquely differentiated type of wearable technology, characterized by noninvasive, intimate integration with the soft, curved, time-dynamic surfaces of the body. This review summarizes the latest advances in this emerging field of "bio-integrated" technologies in a comprehensive manner that connects fundamental developments in chemistry, material science, and engineering with sensing technologies that have the potential for widespread deployment and societal benefit in human health care. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00573DOI Listing
January 2019

Metallomimetic Chemistry of Boron.

Chem Rev 2019 Jan 14. Epub 2019 Jan 14.

The study of main-group molecules that behave and react similarly to transition-metal (TM) complexes has attracted significant interest in recent decades. Most notably, the attractive idea of replacing the all-too-often rare and costly metals from catalysis has motivated efforts to develop main-group-element-mediated reactions. Main-group elements, however, lack the electronic flexibility of TM complexes that arises from combinations of empty and filled d orbitals and that seem ideally suited to bind and activate many substrates. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00561DOI Listing
January 2019
1 Read

Toward Multi-Targeted Platinum and Ruthenium Drugs-A New Paradigm in Cancer Drug Treatment Regimens?

Chem Rev 2019 Jan 14. Epub 2019 Jan 14.

Centre for Synthesis and Chemical Biology, Department of Chemistry , Royal College of Surgeons in Ireland , 123 St. Stephen's Green , Dublin 2 , Ireland.

While medicinal inorganic chemistry has been practised for over 5000 years, it was not until the late 1800s when Alfred Werner published his ground-breaking research on coordination chemistry that we began to truly understand the nature of the coordination bond and the structures and stereochemistries of metal complexes. We can now readily manipulate and fine-tune their properties. This had led to a multitude of complexes with wide-ranging biomedical applications. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00271DOI Listing
January 2019
1 Read

Quantum and Dielectric Confinement Effects in Lower-Dimensional Hybrid Perovskite Semiconductors.

Chem Rev 2019 Jan 14. Epub 2019 Jan 14.

Univ Rennes, INSA Rennes, CNRS, Institut FOTON - UMR 6082 , F-35000 Rennes , France.

Hybrid halide perovskites are now superstar materials leading the field of low-cost thin film photovoltaics technologies. Following the surge for more efficient and stable 3D bulk alloys, multilayered halide perovskites and colloidal perovskite nanostructures appeared in 2016 as viable alternative solutions to this challenge, largely exceeding the original proof of concept made in 2009 and 2014, respectively. This triggered renewed interest in lower-dimensional hybrid halide perovskites and at the same time increasingly more numerous and differentiated applications. Read More

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http://pubs.acs.org/doi/10.1021/acs.chemrev.8b00417
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http://dx.doi.org/10.1021/acs.chemrev.8b00417DOI Listing
January 2019
6 Reads

Mechanistic Landscape of Membrane-Permeabilizing Peptides.

Chem Rev 2019 Jan 9. Epub 2019 Jan 9.

Department of Biochemistry and Molecular Biology Tulane University School of Medicine , New Orleans , Louisiana 70112 , United States.

Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer membranes they act upon. Produced by all forms of life, most membrane permeabilizing peptides are used offensively or defensively against the membranes of other organisms. Just as nature has found many uses for them, translational scientists have worked for decades to design or optimize membrane permeabilizing peptides for applications in the laboratory and in the clinic ranging from antibacterial and antiviral therapy and prophylaxis to anticancer therapeutics and drug delivery. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00520DOI Listing
January 2019
1 Read

Computational Modeling of Realistic Cell Membranes.

Chem Rev 2019 Jan 9. Epub 2019 Jan 9.

Department of Biochemistry , University of Oxford , South Parks Road , Oxford OX1 3QU , U.K.

Cell membranes contain a large variety of lipid types and are crowded with proteins, endowing them with the plasticity needed to fulfill their key roles in cell functioning. The compositional complexity of cellular membranes gives rise to a heterogeneous lateral organization, which is still poorly understood. Computational models, in particular molecular dynamics simulations and related techniques, have provided important insight into the organizational principles of cell membranes over the past decades. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00460DOI Listing
January 2019
2 Reads

Intracellular Catalysis with Selected Metal Complexes and Metallic Nanoparticles: Advances toward the Development of Catalytic Metallodrugs.

Chem Rev 2019 Jan 8. Epub 2019 Jan 8.

Inorganic Chemistry I-Bioinorganic Chemistry , Ruhr University Bochum , Universitätsstrasse 150 , 44780-D Bochum , Germany.

Platinum-containing drugs (e.g., cisplatin) are among the most frequently used chemotherapeutic agents. Read More

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http://pubs.acs.org/doi/10.1021/acs.chemrev.8b00493
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http://dx.doi.org/10.1021/acs.chemrev.8b00493DOI Listing
January 2019
3 Reads

Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis.

Chem Rev 2019 Jan 4. Epub 2019 Jan 4.

Department of Biochemistry , Vanderbilt University , Nashville , Tennessee 37240 , United States.

Advances over the past 25 years have revealed much about how the structural properties of membranes and associated proteins are linked to the thermodynamics and kinetics of membrane protein (MP) folding. At the same time biochemical progress has outlined how cellular proteostasis networks mediate MP folding and manage misfolding in the cell. When combined with results from genomic sequencing, these studies have established paradigms for how MP folding and misfolding are linked to the molecular etiologies of a variety of diseases. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00532DOI Listing
January 2019
1 Read

DNA Quadruple Helices in Nanotechnology.

Chem Rev 2019 Jan 3. Epub 2019 Jan 3.

Department of Molecular Biology & Biochemistry , Simon Fraser University , Burnaby , British Columbia V5A 1S6 , Canada.

DNA has played an early and powerful role in the development of bottom-up nanotechnologies, not least because of DNA's precise, predictable, and controllable properties of assembly on the nanometer scale. Watson-Crick complementarity has been used to build complex 2D and 3D architectures and design a number of nanometer-scale systems for molecular computing, transport, motors, and biosensing applications. Most of such devices are built with classical B-DNA helices and involve classical A-T/U and G-C base pairs. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00629DOI Listing
January 2019
1 Read

Electrically-Transduced Chemical Sensors Based on Two-Dimensional Nanomaterials.

Chem Rev 2019 Jan 3. Epub 2019 Jan 3.

Department of Chemistry, Burke Laboratory , Dartmouth College , Hanover , New Hampshire 03755 , United States.

Electrically-transduced sensors, with their simplicity and compatibility with standard electronic technologies, produce signals that can be efficiently acquired, processed, stored, and analyzed. Two dimensional (2D) nanomaterials, including graphene, phosphorene (BP), transition metal dichalcogenides (TMDCs), and others, have proven to be attractive for the fabrication of high-performance electrically-transduced chemical sensors due to their remarkable electronic and physical properties originating from their 2D structure. This review highlights the advances in electrically-transduced chemical sensing that rely on 2D materials. Read More

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http://pubs.acs.org/doi/10.1021/acs.chemrev.8b00311
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http://dx.doi.org/10.1021/acs.chemrev.8b00311DOI Listing
January 2019
4 Reads

Column Characterization and Selection Systems in Reversed-Phase High-Performance Liquid Chromatography.

Chem Rev 2019 Jan 3. Epub 2019 Jan 3.

Department of Environmental Chemistry and Bioanalytics, Center for Modern Interdisciplinary Technologies , Nicolaus Copernicus University , Wileńska 4 , 87-100 Toruń , Poland.

Reversed-phase high-performance liquid chromatography (RP-HPLC) is the most popular chromatographic mode, accounting for more than 90% of all separations. HPLC itself owes its immense popularity to it being relatively simple and inexpensive, with the equipment being reliable and easy to operate. Due to extensive automation, it can be run virtually unattended with multiple samples at various separation conditions, even by relatively low-skilled personnel. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00246DOI Listing
January 2019
3 Reads

First-Row Transition Metal (De)Hydrogenation Catalysis Based On Functional Pincer Ligands.

Chem Rev 2018 Dec 31. Epub 2018 Dec 31.

Universität Göttingen , Institut für Anorganische Chemie , Tammannstrasse 4 , D-37077 Göttingen , Germany.

The use of 3d metals in de/hydrogenation catalysis has emerged as a competitive field with respect to "traditional" precious metal catalyzed transformations. The introduction of functional pincer ligands that can store protons and/or electrons as expressed by metal-ligand cooperativity and ligand redox-activity strongly stimulated this development as a conceptual starting point for rational catalyst design. This review aims at providing a comprehensive picture of the utilization of functional pincer ligands in first-row transition metal hydrogenation and dehydrogenation catalysis and related synthetic concepts relying on these such as the hydrogen borrowing methodology. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00555DOI Listing
December 2018
2 Reads

Versatile Types of Organic/Inorganic Nanohybrids: From Strategic Design to Biomedical Applications.

Chem Rev 2019 Feb 28;119(3):1666-1762. Epub 2018 Dec 28.

State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Key Laboratory of Carbon Fiber and Functional Polymers (Beijing University of Chemical Technology), Ministry of Education , Beijing University of Chemical Technology , Beijing , 100029 , China.

Organic/inorganic nanohybrids have attracted widespread interests due to their favorable properties and promising applications in biomedical areas. Great efforts have been made to design and fabricate versatile nanohybrids. Among different organic components, diverse polymers offer unique avenues for multifunctional systems with collective properties. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00401DOI Listing
February 2019
2 Reads

The RTK Interactome: Overview and Perspective on RTK Heterointeractions.

Chem Rev 2018 Dec 27. Epub 2018 Dec 27.

Department of Materials Science and Engineering, Institute for NanoBioTechnology, and Program in Molecular Biophysics , Johns Hopkins University , Baltimore , Maryland 21218 , United States.

Receptor tyrosine kinases (RTKs) play important roles in cell growth, motility, differentiation, and survival. These single-pass membrane proteins are grouped into subfamilies based on the similarity of their extracellular domains. They are generally thought to be activated by ligand binding, which promotes homodimerization and then autophosphorylation in trans. Read More

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http://pubs.acs.org/doi/10.1021/acs.chemrev.8b00467
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http://dx.doi.org/10.1021/acs.chemrev.8b00467DOI Listing
December 2018
5 Reads

Iridium-Catalyzed Asymmetric Allylic Substitution Reactions.

Chem Rev 2019 Feb 24;119(3):1855-1969. Epub 2018 Dec 24.

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry , University of Chinese Academy of Sciences, Chinese Academy of Sciences , 345 Lingling Lu , Shanghai 200032 , China.

In this review, we summarize the origin and advancements of iridium-catalyzed asymmetric allylic substitution reactions during the past two decades. Since the first report in 1997, Ir-catalyzed asymmetric allylic substitution reactions have attracted intense attention due to their exceptionally high regio- and enantioselectivities. Ir-catalyzed asymmetric allylic substitution reactions have been significantly developed in recent years in many respects, including ligand development, mechanistic understanding, substrate scope, and application in the synthesis of complex functional molecules. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00506DOI Listing
February 2019
1 Read

Catalysis with Two-Dimensional Materials Confining Single Atoms: Concept, Design, and Applications.

Chem Rev 2019 Feb 21;119(3):1806-1854. Epub 2018 Dec 21.

State Key Laboratory of Catalysis, Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) , Dalian Institute of Chemical Physics (DICP), Chinese Academy of Sciences (CAS) , Dalian 116023 , P. R. China.

Two-dimensional materials and single-atom catalysts are two frontier research fields in catalysis. A new category of catalysts with the integration of both aspects has been rapidly developed in recent years, and significant advantages were established to make it an independent research field. In this Review, we will focus on the concept of two-dimensional materials confining single atoms for catalysis. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00501DOI Listing
February 2019
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Hydride Transfer Reactions Catalyzed by Cobalt Complexes.

Chem Rev 2018 Dec 19. Epub 2018 Dec 19.

Center of Basic Molecular Science (CBMS), Department of Chemistry , Tsinghua University , Beijing 100084 , China.

Cobalt has become increasingly attractive in homogeneous catalysis because of its unique characteristics and outstanding catalytic performance in addition to being cheap and earth-abundant. Hydride transfer processes are involved in a broad range of organic transformations that allow the facile preparation of various useful chemicals and synthetic building blocks. These reactions have continuously received great attention both from academia and industry. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00404DOI Listing
December 2018
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Theoretical Insights into Heterogeneous (Photo)electrochemical CO Reduction.

Chem Rev 2018 Dec 18. Epub 2018 Dec 18.

Electrochemical and photoelectrochemical CO reduction technologies offer the promise of zero-carbon-emission renewable fuels needed for heavy-duty transportation. However, the inert nature of the CO molecule poses a fundamental challenge that must be overcome before efficient (photo)electrochemical CO reduction at scale will be achieved. Optimal catalysts exhibit enduring stability, fast kinetics, high selectivity, and low manufacturing cost. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00481DOI Listing
December 2018
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Impedance-Based Detection of Bacteria.

Chem Rev 2018 Dec 17. Epub 2018 Dec 17.

Department of Chemistry , University of California , Berkeley , California 94720-1460 , United States.

Pathogenic bacteria have always posed one of the most serious threats to public health, and continue to be especially dangerous with the rise in antibiotic resistance. The prevalence of these infectious agents necessitates rapid, point-of-care sensors for their detection, identification, and monitoring. Electrochemical sensors are promising for the low-cost monitoring of bacterial growth and the detection of specific microbial species due to the consistency and ease-of-use of impedance measurements. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00381DOI Listing
December 2018
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Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks.

Chem Rev 2018 Dec 14. Epub 2018 Dec 14.

University of California , San Diego, 9500 Gilman Drive, BRFII , La Jolla , CA 92093-0702 , United States.

Cellular signaling networks are the foundation which determines the fate and function of cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over 25 years ago enabled the development of a diverse array of genetically encodable fluorescent biosensors that are capable of measuring the spatiotemporal dynamics of signal transduction pathways in live cells. In an effort to encapsulate the breadth over which fluorescent biosensors have expanded, we endeavored to assemble a comprehensive list of published engineered biosensors, and we discuss many of the molecular designs utilized in their development. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00333DOI Listing
December 2018
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Iron Catalysis in Reduction and Hydrometalation Reactions.

Chem Rev 2018 Dec 14. Epub 2018 Dec 14.

Univ Rennes, CNRS, ISCR-UMR 6226 , F-35000 Rennes , France.

The last two decades have seen an impressive improvement of the use of iron as a fascinating and valuable alternative transition metal in homogeneous catalysis in terms of sustainability and economy. It was efficiently used in catalytic organic synthetic transformations, which in particular include the reduction of unsaturated bonds. This review summarizes the fast development and the recent advances in selective reductions of olefins, alkynes, carbonyl and carboxylic derivatives, imines, and nitro compounds promoted by iron catalysts. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00372DOI Listing
December 2018
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Metal-Metal (MM) Bond Distances and Bond Orders in Binuclear Metal Complexes of the First Row Transition Metals Titanium Through Zinc.

Chem Rev 2018 Dec 13. Epub 2018 Dec 13.

Centre for Computational Quantum Chemistry , University of Georgia , Athens , Georgia 30602 , United States.

This survey of metal-metal (MM) bond distances in binuclear complexes of the first row 3d-block elements reviews experimental and computational research on a wide range of such systems. The metals surveyed are titanium, vanadium, chromium, manganese, iron, cobalt, nickel, copper, and zinc, representing the only comprehensive presentation of such results to date. Factors impacting MM bond lengths that are discussed here include (a) the formal MM bond order, (b) size of the metal ion present in the bimetallic core (M) , (c) the metal oxidation state, (d) effects of ligand basicity, coordination mode and number, and (e) steric effects of bulky ligands. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00297DOI Listing
December 2018
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Correction to Structural and Chemical Biology of Terpenoid Cyclases.

Chem Rev 2018 Dec 12. Epub 2018 Dec 12.

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http://dx.doi.org/10.1021/acs.chemrev.8b00682DOI Listing
December 2018
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Supramolecular Luminescent Sensors.

Chem Rev 2018 Dec 3. Epub 2018 Dec 3.

Department of Chemistry , University of Rhode Island , 140 Flagg Road , Kingston , Rhode Island 02881 , United States.

There is great need for stand-alone luminescence-based chemosensors that exemplify selectivity, sensitivity, and applicability and that overcome the challenges that arise from complex, real-world media. Discussed herein are recent developments toward these goals in the field of supramolecular luminescent chemosensors, including macrocycles, polymers, and nanomaterials. Specific focus is placed on the development of new macrocycle hosts since 2010, coupled with considerations of the underlying principles of supramolecular chemistry as well as analytes of interest and common luminophores. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00260DOI Listing
December 2018
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Site-Selective Functionalization of Hydroxyl Groups in Carbohydrate Derivatives.

Chem Rev 2018 Dec 3. Epub 2018 Dec 3.

Department of Chemistry , University of Toronto , 80 St. George Street , Toronto , ON M5S 3H6 , Canada.

Methods for site-selective transformations of hydroxyl groups in carbohydrate derivatives are reviewed. The construction of oligosaccharides of defined connectivity hinges on such transformations, which are also needed for the preparation of modified or non-natural sugar derivatives, the installation of naturally occurring postglycosylation modifications, the selective labeling or conjugation of carbohydrate derivatives, and the preparation of therapeutic agents or research tools for glycobiology. The review begins with a discussion of intrinsic factors and processes that can influence selectivity in reactions of unprotected or partially protected carbohydrate derivatives, followed by a description of transformations that engage two OH groups in cyclic adducts (acetals, ketals, boronic esters, and related species). Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00442DOI Listing
December 2018
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Metal Compounds against Neglected Tropical Diseases.

Chem Rev 2018 Dec 3. Epub 2018 Dec 3.

Laboratory for Inorganic Chemical Biology, Chimie ParisTech , PSL University , 11 rue Pierre et Marie Curie , F-75005 Paris , France.

Many first-line treatments for neglected tropical diseases identified by the World Health Organization (WHO) are limited by one or more of the following: the development of drug resistance, toxicity, and side effects, lack of selectivity, narrow therapeutic indices, route of administration, and bioavailability. As such, there is an urgent need to develop viable alternatives to overcome these limitations. The following review provides an overview of all existing metal complexes studied and evaluates the status of these complexes on the respective disease of choice. Read More

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http://pubs.acs.org/doi/10.1021/acs.chemrev.8b00338
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http://dx.doi.org/10.1021/acs.chemrev.8b00338DOI Listing
December 2018
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Cation-π Interactions in Organic Synthesis.

Authors:
Shinji Yamada

Chem Rev 2018 Dec 3. Epub 2018 Dec 3.

Department of Chemistry, Faculty of Science , Ochanomizu University , 2-1-1 Otsuka , Bunkyo-ku , Tokyo 112-8610 , Japan.

The cation-π interaction is an attractive noncovalent interaction between a cation and a π system. Due to the stronger interaction energy than those of the other π interactions, such as π-π and CH-π interactions, the cation-π interaction has recently been recognized as a new tool for controlling the regio- and stereoselectivities in various types of organic reactions. This review attempts to cover a variety of organic reactions controlled by cation-π interactions, which includes not only recent examples but also those reported before the term "cation-π interaction" was defined in 1990. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00377DOI Listing
December 2018
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