1,361,974 results match your criteria Chemical Reviews [Journal]
Nanotechnology 2018 Dec 17. Epub 2018 Dec 17.
Department of Chemical Engineering, National Cheng Kung University, Tainan 701, Taiwan, Tainan, TAIWAN.
Three-dimensional (3D) nickel phosphide/reduced graphene oxide/nickel oxide composite on nickel foam (Ni2P/rGO/NiO/NF) is fabricated as a supercapacitor electrode material via the two-step electrochemical deposition of graphene oxide (GO) and nickel phosphide on the nickel foam. Typically, rGO/NiO/NF is fabricated at first by the electrochemical treatment of nickel foam at 10 V in 0.1 M sulfuric acid with GO for 10 min. Read More
Nanotechnology 2018 Dec 17. Epub 2018 Dec 17.
Materials Science&Engineering, East China University of Science and Technology, No.130, Meilong Rd, Xuhui District, Shanghai, Shanghai, 200237, CHINA.
Although the special architecture of two-dimensional (2D) nanomaterials endows them with unique properties, their poor colloidal stability remains a main bottleneck to fully exploit their applications in the biomedical field. Herein, this study aims to develop a simple and effective approach to in situ incorporate 2D graphene oxide (GO) nanopletlets into thermosensitive matrix to acquire hybrid nanogels with good stability and photothermal effect. In order to improve its stability, GO firstly underwent silanization to its surface with double bonds, followed by intercalation with N-isopropylacrylamide (NIPAM) in the presence of disulfide-containing crosslinker via an emulsion method. Read More
Biomed Mater 2018 Dec 17. Epub 2018 Dec 17.
Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai, CHINA.
Biological regeneration of articular cartilage continues to be a challenge at present. Functional engineered implants with patient-specific sizes are difficult to achieve. The aim of this study is to fabricate a biocompatible cell-laden hydrogel with a designable structure. Read More
J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.
J Xiao, The College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China.
Puberty onset is a complex trait regulated by multiple genetic and environmental factors. In this study, we narrowed a puberty related QTL region down to a 1.7 Mb region on chromosome X in female mice and inferred miR-505-3p as the functional gene. Read More
Endocr Connect 2018 Dec 1. Epub 2018 Dec 1.
Z Wang, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.
Angiogenesis has a pivotal role in the growth and metastasis of pancreatic neuroendocrine tumors (PNETs). Apatinib inhibits angiogenesis as a highly selective VEGFR2 inhibitor and has been used to treat advanced gastric cancer and malignancies in clinical settings. However, the efficacy of apatinib in PNETs remains unclear. Read More
Spectrochim Acta A Mol Biomol Spectrosc 2018 Dec 11;211:272-279. Epub 2018 Dec 11.
Key Laboratory of Chemical Biology, Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China. Electronic address:
The aggregation-induced emission (AIE) luminogens are now showing strong potential in mimicking the energy donor of fluorescence resonance energy transfer (FRET) system. Herein, one highly efficient FRET system 1-NiR is successfully fabricated in aqueous solution based on an AIE active compound 1 and fluorescence dyes (Nile red (NiR)). 1 acts as the energy donor and NiR acts as the acceptor in the FRET system with the optimum concentrations ratio /[NiR] = 100. Read More
Biosens Bioelectron 2018 Dec 7;126:785-791. Epub 2018 Dec 7.
School of Chemical Engineering, Shandong University of Technology, Zibo 255049, PR China.
An ultrasensitive sandwich-type electrochemical immunosensor was designed by using gold nanoparticles (Au NPs) as the substrate material and microporous carbon spheres (CS) loading silver nanoparticles (Ag NPs) spaced Hemin/reduced graphene oxide (Hemin/rGO) porous composite materials (Ag NPs@CS-Hemin/rGO) as the detection antibodies (Ab) label for detecting carcinoembryonic antigen (CEA). The Au NPs with good electrical conductivity and biocompatibility could accelerate the electron transfer on the electrode interface and enhance the load capacity of capture antibodies (Ab). Hemin is peroxidase-like substance which has excellent catalytic ability for HO reduction but easy to molecular aggregation and oxidative self-destruction. Read More
Eur J Med Chem 2018 Dec 4;163:583-596. Epub 2018 Dec 4.
State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, No. 38 Xueyuan Road, 100191, Haidian District, Beijing, China. Electronic address:
Sulfated hyaluronic acid (sHA) is chemically synthetic mimetic of glycosaminoglycan (GAG) presenting promising biological functions. Specific sulfation pattern, termed as sulfation code plays critical roles in regulating the binding mode between GAG and proteins. As a structural analogue of chondroitin sulfate (CS), sHA bears much higher molecular weight and is nearly free of other proteoglycan contaminants. Read More
Bioresour Technol 2018 Dec 7;274:533-540. Epub 2018 Dec 7.
Chemical & Environmental Engineering, School of Engineering, RMIT University, 124 La Trobe St., Melbourne, VIC 3000, Australia. Electronic address:
The adoption of process intensification to anaerobic digestion can present significant complications for digester mixing and process performance. This work investigated how increasing the solids concentration of the digester sludge influenced the process at various mixing energy inputs. Based on the results, adequate mixing is defined qualitatively as the input of sufficient energy to mobilize the reactor contents without producing significant regions of inhibitory shear force. Read More
Bioresour Technol 2018 Dec 8;274:525-532. Epub 2018 Dec 8.
Department of Housing and Urban-Rural Development of Hunan Provincial, Changsha 410082, PR China.
This study explored the cooperative effects of hydrothermal or activators pretreatment and pyrolysis process on the chemical composition of bean dreg (BD)-derived carbon materials and its adsorption characteristics for methylene blue (MB) further. The results showed that hydrothermal assisted pyrolysis carbon with or without activator (HBK and HB) possess higher BET surface area than no hydrothermal assisted carbon (BKs and B, respectively). But surface area alone was not a critical factor contributing to MB adsorption, it also depends on strong electrostatic interaction and the hydrogen bonding interaction between N in MB combines with OH and COO group of adsorbent surface by pH-dependent adsorption and pseudo-second-order model. Read More
Environ Int 2018 Dec 14;123:325-336. Epub 2018 Dec 14.
State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China. Electronic address:
Background: The evaluation of the chemical impact on human health is usually constrained to the analysis of the health effects of exposure to a single chemical or a group of similar chemicals at one time. The effects of chemical mixtures are seldom analyzed. In this study, we applied three statistical models to assess the association between the exposure to a mixture of seven xenobiotics (three phthalate metabolites, two phenols, and two pesticides) and obesity. Read More
Environ Pollut 2018 Dec 7;246:328-335. Epub 2018 Dec 7.
State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China.
The occurrence and distributions of selected endocrine-disrupting chemicals (EDCs), along with related environmental factors, were investigated in two rivers and six reservoirs in the Pearl River Delta. The vertical profiles of aqueous 4-tert-octylphenol (OP), 4-nonylphenol (NP), and estrone (E1) were constant, with little change in concentration between the surface and the river bottom, while higher aqueous concentrations of bisphenol A (BPA) were found in the bottom layers of the rivers. OP and NP in suspended particulate matter (SPM) were transferred from the surface to the bed layer, ultimately accumulating in the sediment. Read More
Environ Pollut 2018 Dec 8;246:294-302. Epub 2018 Dec 8.
Department of Scienze Chimiche e Geologiche, Università di Cagliari and INSTM, Cittadella Universitaria di Monserrato, 09042, Monserrato, Cagliari, Italy.
In this work PM was collected during winter and summer in a Sardinian village (Gonnostramatza, Italy) highly affected by biomass burning emissions. A multi-technique approach was adopted for the complete PM chemical characterization. The bulk characterization was performed by IC (Ion Chromatography), HPAEC (High-Performance Anion-Exchange Chromatography), TOT (Thermal Optical Transmittance) and ED-XRF (Energy-Dispersive X-Ray Fluorescence) while XPS (X-ray Photoelectron Spectroscopy) was used for the surface characterization. Read More
Environ Pollut 2018 Dec 7;246:274-283. Epub 2018 Dec 7.
Department of Civil & Environmental Engineering, University of Wisconsin-Madison, Madison, 53705, USA; Environmental Chemistry and Technology, University of Wisconsin-Madison, Madison, 53706, USA. Electronic address:
Two hundred sixty-three fine particulate matter (PM) samples were collected over fourteen months in Fresno and Bakersfield, California. Samples were analyzed for organic carbon (OC), elemental carbon (EC), water soluble organic carbon (WSOC), and 160 organic molecular markers. Chemical Mass Balance (CMB) and Positive Matrix Factorization (PMF) source apportionment models were applied to the results in order to understand monthly and seasonal source contributions to PM OC. Read More
Environ Pollut 2018 Dec 3;246:264-273. Epub 2018 Dec 3.
Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, China; Beijing Innovation Consortium of Agriculture Research System, Beijing, 100193, China. Electronic address:
Many crops are produced using soil fumigation and chemical pesticides to control soil-borne fungi and bacterial diseases, nematodes and weeds. Fumigation of soil, however, may alter its ability to adsorb, degrade and volatilize pesticides, which can then change the potential for pesticides to leach into groundwater. Soil adsorption kinetics, Freundlich isothermal adsorption and pesticide degradation techniques were used to determine the potential for pesticides to pollute groundwater in fumigated soil. Read More
Environ Pollut 2018 Dec 7;246:257-263. Epub 2018 Dec 7.
Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China; Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control, School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou 510006, Guangdong, PR China. Electronic address:
This work aimed to determine the concentrations of parabens and triclosan (TCS) in shellfish from coastal waters of Shenzhen, South China. A method of isotope dilution with high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was used to determine TCS and five paraben analogues, including methyl paraben (MeP), ethyl paraben (EtP), propyl paraben (PrP), butyl paraben (BuP), and benzyl paraben (BeP), in 186 shellfish samples covering eight species. Concentrations of parabens and TCS were 0. Read More
Environ Pollut 2018 Dec 4;246:225-236. Epub 2018 Dec 4.
College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China; CAS Center for Excellence in Regional Atmospheric Environment, Chinese Academy of Sciences, Xiamen, 361021, China. Electronic address:
In the study, personal PM exposures and their source contributions were characterized for 159 subjects living in the Beijing Metropolitan area. The exposures and sources were examined as functions of residential location, season, vocation, cigarette smoking, and time spent outdoors. Sampling was performed for two categories of volunteers, guards and students, that lived in urban and suburban areas of Beijing. Read More
J Pharm Biomed Anal 2018 Dec 10;165:233-241. Epub 2018 Dec 10.
Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
To identify more chemical markers for improving the quality standard and evaluate producing areas differentiation of Astragali Radix (AR), a simple, low-cost and reliable chromatography method based on a high performance liquid chromatography (HPLC) coupled with ultraviolet (UV) detector and charged aerosol detector (CAD) for separation of 13 major chemical components, including 8 flavonoids and 5 astragalosides in AR extract, was developed. The contents of 13 compounds in total of 27 herb samples, collected from different cultivating regions, were determined and compared. Moreover, chemometric analysis techniques with principal component constituent analysis (PCA) and cluster analysis (CA) were performed to discriminate the samples from different producing areas. Read More
Water Res 2018 Nov 28;151:1-7. Epub 2018 Nov 28.
Department of Biotechcnology, Delft University of Technology, Delft, the Netherlands. Electronic address:
Microbial biofilms can be both cause and cure to a range of emerging societal problems including antimicrobial tolerance, water sanitation, water scarcity and pollution. The identities of extracellular polymeric substances (EPS) responsible for the establishment and function of biofilms are poorly understood. The lack of information on the chemical and physical identities of EPS limits the potential to rationally engineer biofilm processes, and impedes progress within the water and wastewater sector towards a circular economy and resource recovery. Read More
Colloids Surf B Biointerfaces 2018 Dec 5;175:403-408. Epub 2018 Dec 5.
Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka, Osaka 560-8531, Japan. Electronic address:
The J-aggregate of chlorophyll a (Chla) functions as a light-harvesting antenna in natural systems. In this study, we employed the phospholipid membranes composed of longer-chain 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and shorter-chain 1,2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC), as a platform to induce Chla aggregates. The DMPC/DHPC assembly at the mixing ratio (q) = 1. Read More
Chemosphere 2018 Dec 7;219:713-723. Epub 2018 Dec 7.
Food Engineering and Technology Department, Institute of Chemical Technology, Mumbai 400019, Maharashtra, India.
The release of nanomaterials in water reservoirs is hazardous. Very few reports are available on the interaction of different sized nanoparticles with aquatic organisms and aquatic environment. In the present study, silver nanoparticles (AgNPs) having an average particle size of 20. Read More
Chemosphere 2018 Dec 8;219:684-694. Epub 2018 Dec 8.
Géosciences Environnement Toulouse (GET), Observatoire Midi Pyrénées, CNRS, IRD, Université de Toulouse, 31400 Toulouse, France.
In some locations, artisanal and small-scale gold-mining (ASGM) represents a significant source of anthropogenic Hg to freshwater environments. The Hg released from ASGM can contaminate aquatic fauna and pose health risks to downstream populations. Total Hg (THg) concentrations, speciation, and isotopic compositions were analyzed in water, suspended particulate matter, soil, and bottom sediment samples from pristine areas and in places of active and legacy gold mining along the Oyapock River (French Guiana) and its tributaries. Read More
Chemosphere 2018 Dec 7;219:671-677. Epub 2018 Dec 7.
Departamento de Ecología Evolutiva, Estación Biológica de Doñana, CSIC, Avda. Américo Vespucio s/n, 41092, Sevilla, Spain. Electronic address:
Amphibians are considered one of the groups most susceptible to chemical contamination, therefore are good bio-indicators of aquatic pollution. Synergistic effects of temperature and pesticides have been found in amphibians determining amplified toxicity effect on survival and malformations with increasing temperatures. We studied the sensitivity of sublethal concentrations of chlorpyrifos in Rhinella arenarum tadpoles over on two fitness related thermal traits: locomotor swimming performance and thermal tolerance limits (CT = critical thermal maximum and CT = critical thermal minimum). Read More
Acta Biomater 2018 Dec 14. Epub 2018 Dec 14.
College of Pharmaceutical Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, PR China. Electronic address:
In this study, an AIE-active polymer (FTP) was successfully prepared and employed to load anti-cancer drug doxorubicin (DOX) for self-indicating cancer therapy via dual FRET process. Our results demonstrated that the FTP polymer could self-assemble into nanoparticles (NPs) in aqueous solutions to give strong fluorescence emission via intramolecular FRET process. The DOX loaded FTP NPs (drug loading content: 21. Read More
Acta Biomater 2018 Dec 14. Epub 2018 Dec 14.
Centre for Biomaterials in Surgical Reconstruction and Regeneration, Division of Surgery & Interventional Science, University College London, London, NW3 2PF, United Kingdom. Electronic address:
Increasing evidence suggests the contribution of the dynamic mechanical properties of the extracellular matrix (ECM) to regulate tissue remodeling and regeneration. Following our recent study on a family of thermoresponsive 'stiffness memory' elastomeric nanohybrid scaffolds manufactured via an indirect 3D printing guided thermo-induced phase separation process (3D-TIPS), this work reports in vitro and in vivo cellular responses towards these scaffolds with different initial stiffness and hierarchical interconnected porous structure. The viability of mouse embryonic dermal fibroblasts in vitro and the tissue responses during the stiffness softening of the scaffolds subcutaneously implanted in rats for three months were evaluated by immunohistochemistry and histology. Read More
J Control Release 2018 Dec 14. Epub 2018 Dec 14.
School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, 950 Atlantic Dr. NW, Atlanta, GA 30332, USA. Electronic address:
Enzymes with intracellular activity have significant potential to treat diseases. Protein nanoparticles (NPs) considerably enhance intracellular delivery of enzymes. We have previously shown that a Salmonella effector enzyme, AvrA, delivered by NPs is capable of modulating inflammatory signals in a murine dextran sulfate sodium (DSS) colitis model. Read More
Int J Biol Macromol 2018 Dec 14. Epub 2018 Dec 14.
Malaysian Institute of Pharmaceuticals and Nutraceuticals, NIBM, 11700 Gelugor, Penang, Malaysia; School of Biological Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia; Centre for Chemical Biology, Universiti Sains Malaysia, 11900 Bayan Lepas, Penang, Malaysia. Electronic address:
P(3HB-co-4HB) with a high 4HB monomer composition was previously successfully produced using the transformant Cupriavidus malaysiensis USMAA1020 containing an additional copy of the PHA synthase gene. In this study, high PHA density fed-batch cultivation strategies were developed for such 4HB-rich P(3HB-co-4HB). The pulse, constant and mixed feeding strategies resulted in high PHA accumulation, with a PHA content of 74-92 wt% and 4HB monomer composition of 92-99 mol%. Read More
Int J Biol Macromol 2018 Dec 14. Epub 2018 Dec 14.
School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
In this work, a biobased adsorbent (CMC-PAMA) consisting of sodium carboxymethyl cellulose, polyacrylic acid and polyacrylamide was prepared by a simple thermal crosslinking method for the removal of methylene blue (MB) and Pb (II) from aqueous solutions. The CMC-PAMA showed excellent static adsorption capacities for MB and Pb (II) of 1611.44 mg·g 840. Read More
Int J Biol Macromol 2018 Dec 14. Epub 2018 Dec 14.
Liaoning Provincial Key Laboratory of Carbohydrates, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address:
To investigate the effect and mechanism of chitosan nanoparticles (CSNPs) on the germination and seedling growth of wheat (Triticum aestivum L.), we conducted systematic research on the impact of different concentrations (1-100 μg/mL) of CSNPs and chitosan (CS). The result of energy-dispersive spectroscopy (EDS) and confocal laser scanning microscopy (CLSM) showed that adsorption of CSNPs on the surface of wheat seeds was higher than that of CS. Read More
Nitric Oxide 2018 Dec 14. Epub 2018 Dec 14.
Department of Polymers and Composites, N.N.Semenov Institute of Chemical Physics, RAS, 4 Kosygin St., Moscow, 119991, Russia; Institute for Regenerative Medicine, Sechenov University, 8-2 Trubetskaya St., Moscow, 119991, Russia; Institute of Photonic Technologies, Research Center "Crystallography and Photonics", RAS, 2 Pionerskaya st., Troitsk, Moscow, 142190, Russia.
We have studied the effect of interactions between dinitrosyl iron complexes with thiol-containing ligands (DNIC-TL) and diglucamine salt of chlorine e6 (photoditazine, PD) on the rate of photosensitized oxidation of a model organic substrate - tryptophan - in the presence and absence of an amphiphilic polymer, Pluronic F127, as well as on the DNIC-TL and PD photostability. Using EPR and UV spectroscopy, we determined the rate constants for photodegradation of mono- and dinuclear DNIC-TL and PD, respectively. The presence of the photosensitizer and Pluronic F127 has been shown to have a negligible effect on the rate of photodestruction of mono- and dinuclear DNIC-TL, taking into account the changing DNIC-TL and PD concentrations in the photoexcitation conditions. Read More
Microb Pathog 2018 Dec 14. Epub 2018 Dec 14.
Department of Chemistry, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, Tamil Nadu, 613401, India. Electronic address:
In this paper, the self assembling properties of taurolipids were used to prepare stable copper nanoparticles (CuNPs), and demonstrated the ability of CuNPs to eradicate the biofilms formed by waterborne pathogens. The synthesized CuNPs display wine red color and exhibited surface plasmon resonance with a maximum at 590 nm. Transmission electron microscopy showed that the CuNPs are well-dispersed with spherical morphology and the size range between 5 and 12 nm. Read More
Math Biosci 2018 Dec 14. Epub 2018 Dec 14.
Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, 98 Brett Road, Piscataway, NJ 08854; Department of Biomedical Engineering, Rutgers The State University of New Jersey, 599 Taylor Road, Piscataway, NJ 08854. Electronic address:
Pharmacokinetic models are particularly useful to study the underlying and complex physiological mechanisms contributing to clinical differences across patient subgroups or special populations. Unfortunately, the inherent variability of biological systems and knowledge gaps in physiological data limit confidence in model predictions for special populations. Sourcing data to reflect the desired physiologies can be resource intensive, particularly for a larger model. Read More
J Org Chem 2018 Dec 17. Epub 2018 Dec 17.
A novel 8(14→15)-abeo-ergostane-type steroid, asperflotone (1), and an ergostane steroid, asperfloroid (2), were isolated from the solid culture of Aspergillus flocculosus 16D-1. Their structures and absolute configurations were determined by HRESIMS, 1D/2D NMR, X-ray crystallography, and quantum chemical calculations. Compound 1 is an unprecedented ergosteroid featuring a rearranged bicyclo[4. Read More
J Org Chem 2018 Dec 17. Epub 2018 Dec 17.
Comprised of a large collection of structurally diverse molecules, the prostaglandins exhibit a wide range of biological properties. Among them are Δ12-prostaglandin J2 (Δ12-PGJ2) and Δ12-prostaglandin J3 (Δ12-PGJ3), whose unusual structural motifs and potent cytotoxicities present unique opportunities for chemical and biological investigations. Herein we report a short olefin-metathesis based total synthesis of Δ12-PGJ2 and its application to the construction of a series of designed analogues possessing monomeric, dimeric, trimeric and tetrameric macrocyclic lactones consisting of units of this prostaglandin. Read More
Anal Chem 2018 Dec 17. Epub 2018 Dec 17.
Herein, a redox-cycling was proposed to amplify the signal of enzyme-linked immunosorbent assay (ELISA), which was performed in polystyrene microplate based on a classic sandwich-type. After the sandwich immunoreactions were finished, the alkaline phosphatase captured on microplate triggered the hydrolyzation of L-ascorbic acid 2-phosphate to generate ascorbic acid (AA), which then reduced colorless tris(bathophenanthroline) iron(III) (Fe(BPT)33+) encapsulated in the micelle of TX-100 to pink red tris(bathophenanthroline) iron (II) (Fe(BPT)32+). In the presence of tris(2-carboxyethyl)phosphine, the oxidation product, dehydroascorbic acid, was transformed to AA quickly which then reduced Fe(BPT)33+ again and again, resulting in the generation of abundant Fe(BPT)32+ that could be read out conveniently by a commercial microplate reader or naked eyes. Read More
Chemistry 2018 Dec 17. Epub 2018 Dec 17.
Heinrich-Heine-Universität Düsseldorf, Institut für Organische Chemie und Makromolekulare Chemie, Universitätsstrasse 1, 40225, Düsseldorf, GERMANY.
Twofold Buchwald-Hartwig aminations selectively furnish all three regioisomers of bisbenzothieno[1,4]thiazines and X-ray structure analyses and DFT calculations were corroborated for correlation of their electronic properties. All regioisomers outscore the parent compound phenothiazine with respect to a low lying oxidation potential and reversible redox activity. The anti-anti bisbenzothieno[3,2-b:2',3'-e][1,4]thiazines possess the lowest oxidation potentials in this series and display pronounced green luminescence in solution ("Phi"F ≈ 20%) and in the solid state. Read More
Chem Biodivers 2018 Dec 17. Epub 2018 Dec 17.
Univesity of Saskatchewan, Dept. of Chemistry, 110 Science Place, S7N 5C9, Saskatoon, CANADA.
Leaves of the plant species Isatis indigotica Fort. (Chinese woad) produce the metabolites tryptanthrin, indirubin and N-formylanthranilic acid upon spraying with an aq. solution of copper chloride but not after spraying with water. Read More
PLoS One 2018 17;13(12):e0209120. Epub 2018 Dec 17.
Chemical and Biological Signature Science, Pacific Northwest National Laboratory, Richland, Washington, United States of America.
The spore forming pathogen Bacillus anthracis is the etiologic agent of anthrax in humans and animals. It cycles through infected hosts as vegetative cells and is eventually introduced into the environment where it generates an endospore resistant to many harsh conditions. The endospores are subsequently taken up by another host to begin the next cycle. Read More
PLoS One 2018 17;13(12):e0209150. Epub 2018 Dec 17.
Service d'Etude des Prions et Infections Atypiques (SEPIA), Institut François Jacob, CEA, Université Paris-Saclay, Fontenay-aux-Roses, France.
Human mini-brains (MB) are cerebral organoids that recapitulate in part the complexity of the human brain in a unique three-dimensional in vitro model, yielding discrete brain regions reminiscent of the cerebral cortex. Specific proteins linked to neurodegenerative disorders are physiologically expressed in MBs, such as APP-derived amyloids (Aβ), whose physiological and pathological roles and interactions with other proteins are not well established in humans. Here, we demonstrate that neuroectodermal organoids can be used to study the Aβ accumulation implicated in Alzheimer's disease (AD). Read More
PLoS One 2018 17;13(12):e0209195. Epub 2018 Dec 17.
Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Ribonucleoprotein (RNP) granules are higher order assemblies of RNA, RNA-binding proteins, and other proteins, that regulate the transcriptome and protect RNAs from environmental challenge. There is a diverse range of RNP granules, many cytoplasmic, which provide various levels of regulation of RNA metabolism. Here we present evidence that the yeast transcription termination factor, Nab3, is targeted to intranuclear granules in response to glucose starvation by Nab3's proline/glutamine-rich, prion-like domain (PrLD) which can assemble into amyloid in vitro. Read More
PLoS Comput Biol 2018 Dec 17;14(12):e1006641. Epub 2018 Dec 17.
Biochemistry and Structural Biology, University of Lund, Lund, Sweden.
Many proteins consist of folded domains connected by regions with higher flexibility. The details of the resulting conformational ensemble play a central role in controlling interactions between domains and with binding partners. Small-Angle Scattering (SAS) is well-suited to study the conformational states adopted by proteins in solution. Read More
PLoS One 2018 17;13(12):e0208640. Epub 2018 Dec 17.
Department of Physics, Mirpur University of Science and Technology (MUST) Mirpur, Azad Kashmir, Pakistan.
The potential of fluorescence spectroscopy has been utilized for the characterization of three types of canola oil samples: the first type was obtained by dissolving its seeds in hexane solvent, the second by cold press method, and the third from eight commercial brands. Fluorescence spectra from all samples have been acquired by using excitation wavelengths from 280 to 420 nm with step of 10 nm to investigate their valuable ingredients. The emission bands at 375, 525 and 673 nm that represent vitamin E/beta-carotene and chlorophyll, are present only in canola oil samples extracted by chemical and cold press methods and absolutely absent from all commercial brands. Read More
PLoS Biol 2018 Dec 17;16(12):e3000093. Epub 2018 Dec 17.
Integrative Research Center, Field Museum of Natural History, Chicago, United States of America.
Animal signals-involving combinations of acoustic, chemical, visual, and behavioral cues-are among the most diverse traits in nature. Testing hypotheses about signal evolution has been hampered by difficulties with comparing highly divergent signals among species. In this Primer, I describe recent advances in capturing signals and studying their evolution. Read More
PLoS One 2018 17;13(12):e0209286. Epub 2018 Dec 17.
Leibniz Centre for Tropical Marine Research (ZMT), Bremen, Germany.
In nature, a multitude of both abiotic and biotic stressors influence organisms with regard to their overall fitness. Stress responses that finally impair normal biological functions may ultimately result in consequences for whole populations. This study focused on the metabolic response of the intertidal rock pool fish Gobius paganellus towards simulated predation risk. Read More
PLoS Genet 2018 Dec 17;14(12):e1007837. Epub 2018 Dec 17.
Biostatistics Division, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with trait diversity and disease susceptibility, yet their functional properties often remain unclear. It has been hypothesized that SNPs in microRNA binding sites may disrupt gene regulation by microRNAs (miRNAs), short non-coding RNAs that bind to mRNA and downregulate the target gene. While several studies have predicted the location of SNPs in miRNA binding sites, to date there has been no comprehensive analysis of their impact on miRNA regulation. Read More
Xenobiotica 2018 Dec 17:1-22. Epub 2018 Dec 17.
a Department of Surgery and Cancer, Faculty of Medicine , Imperial College London, South Kensington Campus , London , SW7 2AZ, United Kingdom.
1. The metabolic fate and urinary excretion of 2-bromophenol, a phenolic metabolite of bromobenzene, was investigated in male Sprague Dawley rats following single intraperitoneal doses at either 0, 100 or 200 mg/kg. 2. Read More
J Microencapsul 2018 Dec 17:1-39. Epub 2018 Dec 17.
a School of Agriculture and Biology, Shanghai Engineering Research Center of Food Safety , Shanghai Jiao Tong University , Shanghai 200240 , China.
The present work formed lutein-enriched nanoemulsions stabilized by sodium caseinate (SC) using a high-pressure homogenization process, and the influence of environmental conditions on the physicochemical stability of the nanoemulsion were investigated. The results showed that the droplet diameter of the nanoemulsion was largely dependent on homogenization conditions. Optimum results were obtained for 1. Read More
Drug Dev Ind Pharm 2018 Dec 17:1-40. Epub 2018 Dec 17.
a H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences , Karachi University , Karachi , 74200 , Pakistan.
Emergence of multidrug resistance (MDR) has limited the success of chemotherapeutic agents. Reversal of drugs efflux systems through combination therapy has got wider attention for increasing anticancer drugs efficacy. This study aims at co-encapsulation of Paclitaxel with Naringin in mixed polymeric micelles for enhanced anticancer activity of the drug. Read More
Future Med Chem 2018 Dec 17. Epub 2018 Dec 17.
Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44, West Culture Road, Ji'nan 250012, PR China.
Hedgehog (HH) signaling pathway plays vital roles in controlling embryonic cell fate and homeostatic, and becomes dormant in mature individuals, aberrant activation of HH signaling pathway is involved in a number of human cancers. Smoothened (SMO), a vital transducer of HH signaling pathway, attracts significant attentions in HH signaling pathway-related cancer therapy. The approval of SMO antagonists Vismodegib proves that SMO is a promising therapeutic target, and a number of SMO antagonists are reported since then. Read More
J Chem Theory Comput 2018 Dec 17. Epub 2018 Dec 17.
A novel methodology is introduced here to generate coarse-grained (CG) representations of molecular models for simulations. The proposed strategy relies on basic graph-theoretic principles, and is referred to as graph-based coarse-graining (GBCG). It treats a given system as a molecular graph, and derives a corresponding CG representation by using edge contractions to combine nodes in the graph, which correspond to atoms in the molecule, into CG sites. Read More