1,099 results match your criteria Chemical Restraint


Quality Standards of Nursing Care for the Use of Chemical Restraints: A Realist Review.

J Nurs Care Qual 2020 Jul/Sep;35(3):270-275

Faculty of Nursing, University of Montreal, Quebec, Canada (Ms Hupé and Dr Larue and Ms Pépin); School of Nursing, University of Victoria, British Columbia, Canada (Dr Contandriopoulos); and CIUSSS de l'Est-de-l'Île-de-Montreal: Control Measures Research Center/Center for Nursing Excellence, Quebec, Canada (Ms Hupé and Dr Larue and Ms Gazemar).

Background: The use of chemical restraints (CRs) in health care facilities is a complex intervention that raises questions about its effectiveness and whether it is safe and patient oriented.

Purpose: This review aims to gather nursing quality standards for the use of CR through an innovative method of knowledge synthesis, the realist review, to support the development of a quality evaluation tool.

Methods: A realist review method was chosen. Read More

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http://dx.doi.org/10.1097/NCQ.0000000000000453DOI Listing

RSVdb: a comprehensive database of transcriptome RNA structure.

Brief Bioinform 2020 May 8. Epub 2020 May 8.

RNA fulfills a crucial regulatory role in cells by folding into a complex RNA structure. To date, a chemical compound, dimethyl sulfate (DMS), has been developed to probe the RNA structure at the transcriptome level effectively. We proposed a database, RSVdb (https://taolab. Read More

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http://dx.doi.org/10.1093/bib/bbaa071DOI Listing
May 2020
9.617 Impact Factor

Frequent Hand Washing for COVID-19 Prevention Can Cause Hand Dermatitis: Management Tips.

Cureus 2020 Apr 2;12(4):e7506. Epub 2020 Apr 2.

Physical Medicine and Rehabilitation, "Carol Davila" University of Medicine and Pharmacy, Bucharest, ROU.

Coronavirus disease 2019 (COVID-19) continues to spread globally, outpacing the capacity and resources of health systems worldwide. A therapeutic vaccine is not yet on the rise, and preventive measures are the current approach to restraint the transmission of cases. As the virus is highly contagious via respiratory route (droplets from infected persons, widely spread by coughing or sneezing) and via contact with contaminated surfaces, community transmission and spread can be decreased through the practice of regular and diligent hand hygiene. Read More

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http://dx.doi.org/10.7759/cureus.7506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195203PMC

The Conformational Preference of Chemical Cross-linkers Determines the Cross-linking Probability of Reactive Protein Residues.

J Phys Chem B 2020 Jun 19;124(22):4446-4453. Epub 2020 May 19.

CAS Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, National Center for Magnetic Resonance at Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, Hubei Province 430071, China.

Chemical cross-linking mass spectrometry (XLMS) is an emerging technique in structural biology. Providing the cross-linked peptides are identified by mass spectrometry with high confidence, a distance restraint can be applied between the two reactive protein residues, with the upper bound corresponding to the maximal span of the cross-linker. However, as the upper bound is typically over 20 Å, cross-link distance restraints are unrestrictive and provide a marginal improvement in protein structural refinement. Read More

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http://dx.doi.org/10.1021/acs.jpcb.0c02522DOI Listing

Children and adolescents with severe acute behavioural disturbance in the emergency department.

Emerg Med Australas 2020 Apr 28. Epub 2020 Apr 28.

Emergency Department, The Royal Children's Hospital, Melbourne, Victoria, Australia.

Objective: Mental health (MH) presentations to ED are increasing in children and adolescents. Little is known about patients with severe acute behavioural disturbance (ABD). We set out to describe patients with ABD severe enough to trigger an acute crisis team response in ED (termed 'Code Grey') and how they differ from other MH patients. Read More

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http://dx.doi.org/10.1111/1742-6723.13515DOI Listing

Physical and Chemical Restraints (an Update).

Emerg Med Clin North Am 2020 May;38(2):437-451

Department of Emergency Medicine, Cook County Health, 1950 West Polk, 7th Floor EM Admin, Chicago, IL 60612, USA. Electronic address:

Violent, combative and intoxicated patients are a common problem in the emergency department, and the emergency physician must be prepared to control the situation safely and effectively when a patient begins to exhibit dangerous behavior. This article reviews initial de-escalation techniques to reduce the need for patient restraint. It then details the 2 types of restraints (physical and chemical) and the clear indications for each type. Read More

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http://dx.doi.org/10.1016/j.emc.2020.02.002DOI Listing

Role of security guards in Code Black events in medical and surgical settings: A retrospective chart audit.

Nurs Health Sci 2020 Apr 20. Epub 2020 Apr 20.

College of Nursing & Health Sciences, Flinders University, Adelaide, South Australia, Australia.

The prevalence of security guards in health care settings is growing worldwide. There is a need to explore and understand their role and actions to inform policy and training and support least restrictive practices in health care. The aim of this study was to conduct a retrospective chart audit of security guard logs to investigate security guard involvement in Code Blacks, called in emergency situations of personal threats including patient and/or visitor violence, in medical and surgical wards in a large metropolitan health network in South Australia. Read More

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http://dx.doi.org/10.1111/nhs.12725DOI Listing

Natural Habitat, Housing, and Restraint of Six Selected Neotropical Animals in Trinidad and Tobago with the Potential for Domestication.

Scientifica (Cairo) 2020 26;2020:9741762. Epub 2020 Mar 26.

The Open Tropical Forage-Animal Production Laboratory (OTF-APL), Department of Food Production (DFP), Faculty of Food and Agriculture (FFA), The University of the West Indies (UWI), St. Augustine, Trinidad and Tobago.

This paper highlights the natural habitat, housing, and restraint needs of 6 Neotropical animals that are found in Trinidad and Tobago with the potential for domestication: agouti (), lappe/paca (), capybara (), manicou/opossum (), collared peccary (), and red brocket deer (). The year of the earliest reference cited was 1950 and the most recent was 2018, with over 100 references being used. The average density, home range size, social group, and housing requirements were also examined as these factors would play a role in designing enclosures. Read More

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http://dx.doi.org/10.1155/2020/9741762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136804PMC

Impact of Cyanine Conformational Restraint in the Near-Infrared Range.

J Org Chem 2020 May 10;85(9):5907-5915. Epub 2020 Apr 10.

Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 376 Boyles Street, Frederick, Maryland 21702, United States.

Appending conformationally restraining ring systems to the cyanine chromophore creates exceptionally bright fluorophores in the visible range. Here, we report the application of this strategy in the near-infrared range through the preparation of the first restrained heptamethine indocyanine. Time-resolved absorption spectroscopy and fluorescence correlation spectroscopy verify that, unlike the corresponding parent unrestrained variant, the restrained molecule is not subject to photoisomerization. Read More

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http://dx.doi.org/10.1021/acs.joc.0c00236DOI Listing

Radiography and computed tomography of the heart and lower respiratory tract in toco toucans (Ramphastos toco).

Anat Histol Embryol 2020 Apr 7. Epub 2020 Apr 7.

Department of Animal Reproduction and Veterinary Radiology, School of Veterinary Medicine and Animal Science, São Paulo State University (Unesp), Botucatu, Brazil.

This study aimed to evaluate normal features of the heart and lower respiratory tract in toco toucans by means of radiography and helical computed tomography (CT) scanner. Fifteen healthy adult toco toucans (Ramphastos toco), 10 females and 5 males, average body mass of 650 g were studied. CT examination as well as right lateral and ventrodorsal radiographic examinations of the coelomic cavity were performed under chemical restraint. Read More

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http://dx.doi.org/10.1111/ahe.12559DOI Listing

RASGRF1 in CRF cells controls the early adolescent female response to repeated stress.

J Endocrinol 2020 Jun;245(3):397-410

Department of Developmental, Molecular, and Chemical Biology, Boston, Massachusetts, USA.

RASGRF1 (GRF1) is a calcium-stimulated guanine-nucleotide exchange factor that activates RAS and RAC GTPases. In hippocampus neurons, it mediates the action of NMDA and calcium-permeable AMPA glutamate receptors on specific forms of synaptic plasticity, learning, and memory in both male and female mice. Recently, we showed GRF1 also regulates the HPA axis response to restraint stress, but only in female mice before puberty. Read More

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http://dx.doi.org/10.1530/JOE-19-0375DOI Listing

Radiographic Measurements of the Cardiac Silhouette in Healthy Blue-Fronted Amazon Parrots ().

J Avian Med Surg 2020 Mar;34(1):26-31

Department of Animal Reproduction and Radiology, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Rubião Júnior s/n, 18618970, Botucatu, SP, Brazil.

The objective of this investigation was to determine radiographic measurements, without chemical restraint, of the cardiac silhouette in 34 healthy, adult blue-fronted Amazon parrots () of unknown sex with a mean body weight of 393 g. The birds were fasted 3 hours before the radiographic examinations. Three thoracic radiographic views (ventrodorsal, right lateral, and left lateral) were obtained from each bird for assessment. Read More

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http://dx.doi.org/10.1647/1082-6742-34.1.26DOI Listing

Sympathetic Nerves Positively Regulate Eosinophil-Driven Allergic Conjunctivitis via α1-Adrenergic Receptor Signaling.

Am J Pathol 2020 Jun 16;190(6):1298-1308. Epub 2020 Mar 16.

International Ocular Surface Research Center, Institute of Ophthalmology and Key Laboratory for Regenerative Medicine, Jinan University, Guangzhou, China; Department of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou, China; Department of Ophthalmology, Henan Provincial People's Hospital, Henan University People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China. Electronic address:

Eosinophils are a major cause of tissue injury in allergic conjunctivitis. The biological nature of eosinophils in the conjunctiva and the mechanisms that control eosinophils' responses in allergic conjunctivitis are currently not completely understood. This study reports that conjunctival eosinophils comprise two populations-Siglec-F and Siglec-F-in different life stages. Read More

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http://dx.doi.org/10.1016/j.ajpath.2020.02.004DOI Listing
June 2020
4.591 Impact Factor

Physical and Pharmacological Restraints in Hospital Care: Protocol for a Systematic Review.

Front Psychiatry 2019 28;10:921. Epub 2020 Feb 28.

Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.

Background: Physical and pharmacological restraints, defined as all measures limiting a person in his or her freedom, are extensively used to handle unsafe or problematic behavior in hospital care. There are increasing concerns as to the extent with which these restraints are being used in hospitals, and whether their benefits outweigh their potential harm. There is currently no comprehensive literature overview on the beneficial and/or adverse effects of the use of physical and pharmacological restraints in the hospital setting. Read More

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http://dx.doi.org/10.3389/fpsyt.2019.00921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058582PMC
February 2020

The effects of therapeutic activity kits in emergency department patients with dementia: Study protocol for a pragmatic randomized control trial.

J Adv Nurs 2020 Jun 29;76(6):1449-1457. Epub 2020 Mar 29.

Emergency and Trauma Centre, Royal Brisbane and Women's Hospital, Brisbane, Qld, Australia.

Aim: To determine the effectiveness of therapeutic activity kits on health service use and treatment delivered in the emergency department (ED) in patients with pre-morbid dementia.

Design: Pragmatic randomized control trial with equal parallel groups.

Methods: Participants with dementia will be randomly assigned to the control group (N = 56) or the intervention group (N = 56). Read More

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http://dx.doi.org/10.1111/jan.14350DOI Listing
June 2020
1.685 Impact Factor

Evoking Photothermy by Capturing Intramolecular Bond Stretching Vibration-Induced Dark-State Energy.

ACS Nano 2020 Apr 17;14(4):4265-4275. Epub 2020 Mar 17.

Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Division of Life Science and State Key Laboratory of Molecular Neuroscience, and Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.

Development of highly effective approaches to desirable photothermal conversion agents is particularly valuable. Herein, we report a concept, namely, bond stretching vibration-induced photothermy, that serves as a mechanism to construct advanced photothermal conversion agents. As a proof-of-concept, two compounds (DCP-TPA and DCP-PTPA) with donor-acceptor (D-A) structures were synthesized. Read More

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http://dx.doi.org/10.1021/acsnano.9b09625DOI Listing

Comparison of midazolam and butorphanol combined with ketamine or dexmedetomidine for chemical restraint in howler monkeys (Alouatta guariba clamitans) for vasectomy.

J Med Primatol 2020 Mar 10. Epub 2020 Mar 10.

Veterinary School, UFMG, Belo Horizonte, Brazil.

Background: This study evaluated and compared cardiorespiratory and blood gas parameters, as well as sedation, analgesia and recovery of two protocols: ketamine (10 mg/kg) or dexmedetomidine (10 μg/kg), with midazolam (0.5 mg/kg) and butorphanol (0.3 mg/kg), IM (KBM and DBM, respectively) in brown howler monkeys (Alouatta guariba clamitans). Read More

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http://dx.doi.org/10.1111/jmp.12467DOI Listing

LC-APCI-MS/MS method for the analysis of ten hormones and two endocannabinoids in plasma and hair from the mice with different gut microbiota.

J Pharm Biomed Anal 2020 Jun 29;185:113223. Epub 2020 Feb 29.

School of Biological Sciences & Medical Engineering, Southeast University, Nanjing 210096, China; Key Laboratory of Child Development and Learning Science (Southeast University), Ministry of Education, Nanjing 210096, China; Institute of Child Development and Education, Research Center for Learning Science, Southeast University, Nanjing 210096, China. Electronic address:

The effect of gut microbiota on the activity of the HPA and HPG axes and ECS is a short-term or long-lasting process remains unclear in rodents. However, the extant studies focused only on its short-term effect on the HPA activity because there is lack of reliable biomarkers characterizing short-term activity of the HPG axis and ECS and long-term activities of the three endocrine systems. The endogenous levels of aldosterone (ALD), 11-dehydrocorticosterone (11-DHC), estradiol (E2), estrone (E1), androstenedione (A4), dihydrotestosterone (DHT), corticosterone (CORT), dehydroepiandrosterone (DHEA), testosterone (T), progesterone (P), N-arachidonoyl ethanoamide (AEA) and 1-arachydonoyl glycerol (1-AG) in hair and plasma are the potential long-term and short-term biomarkers of the three systems. Read More

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http://dx.doi.org/10.1016/j.jpba.2020.113223DOI Listing
June 2020
2.979 Impact Factor

Ultrafine nanosulfur particles sandwiched in little oxygen-functionalized graphene layers as cathodes for high rate and long-life lithium-sulfur batteries.

Nanotechnology 2020 Mar 3;31(24):245404. Epub 2020 Mar 3.

Institute of Chemical Materials, China Academy of Engineering Physics, Mianyang, Sichuan, 621900, People's Republic of China. Sichuan Research Center of New Materials, Chengdu, Sichuan, 610200, People's Republic of China.

Although lithium-sulfur batteries are one of the promising candidates for next-generation energy storage systems, the practical applications are still hampered by the poor cycle life, which can be attributed to the insulating properties of sulfur and the shuttle effect of electrochemical intermediate polysulfides. To address these problems, we synthesize sandwich-like composites which consist of ultrafine nanosulfur particles enveloped by little oxygen-functionalized graphene layers (F-GS@S). In this structure, the little oxygen-functionalized graphene backbone can not only accelerate the redox kinetics of sulfur species, but also eliminate the shuttle effect of polysulfides by strong chemical interaction. Read More

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http://dx.doi.org/10.1088/1361-6528/ab7c46DOI Listing

Etorphine-Azaperone Immobilisation for Translocation of Free-Ranging Masai Giraffes (): A Pilot Study.

Animals (Basel) 2020 Feb 18;10(2). Epub 2020 Feb 18.

Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, Via dell'Università 6, 26900 Lodi, Italy.

Etorphine-azaperone immobilisation was evaluated for translocation of Masai giraffes. Nine giraffes were darted with 0.012 ± 0. Read More

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http://dx.doi.org/10.3390/ani10020322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070639PMC
February 2020

Interrogating systematic review recommendations for effective chemical restraint.

J Eval Clin Pract 2020 Feb 14. Epub 2020 Feb 14.

College of Nursing & Health Sciences, Flinders University, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1111/jep.13363DOI Listing
February 2020

Comparison of three reversible injectable chemical restraint protocols in Spix´s Owl monkeys (Aotus vociferans) using ketamine, xylazine and midazolam.

J Med Primatol 2020 Jun 12;49(3):136-143. Epub 2020 Feb 12.

School of Veterinary Medicine, Small Animals Hospital, Universidad Nacional Mayor de San Marcos, Lima, Peru.

Background: There is scarce information detailing clinical and physiological effects of reversible injectable protocols of chemical restraint on Neotropical primates.

Methods: Nineteen captive Spix´s Owl monkeys (Aotus vociferans) were assessed in a double-blind randomized crossover study using the following: ketamine/xylazine [KX], ketamine/midazolam [KM] and ketamine/xylazine/midazolam [KXM]. During immobilization, respiratory and pulse rates, rectal temperature, haemoglobin oxygen saturation and arterial blood pressure were recorded at 5-minute intervals during a 20-minute period; afterwards, antagonist drugs (yohimbine for xylazine and flumazenil for midazolam) were, respectively, administered. Read More

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http://dx.doi.org/10.1111/jmp.12462DOI Listing

[Use of sedating medication and physical restraints for patients with dementia in acute care hospitals : A non-randomized case control study].

Z Gerontol Geriatr 2020 Mar 11;53(2):138-144. Epub 2020 Feb 11.

Institut für Medizinische Soziologie, Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Deutschland.

Background: The majority of acute care hospitals are not prepared for people with dementia with acute diseases in need of treatment. This results in an increased likelihood of the personnel being overtaxed. Dementia is the most frequent reason that hospital personnel administer sedating medication and use restraining measures. Read More

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http://dx.doi.org/10.1007/s00391-020-01697-3DOI Listing

Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction.

J Vis Exp 2020 Jan 12(155). Epub 2020 Jan 12.

Pittsburgh Liver Research Center, University of Pittsburgh; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh;

Vinyl chloride (VC), an abundant environmental contaminant, causes steatohepatitis at high levels, but is considered safe at lower levels. Although several studies have investigated the role of VC as a direct hepatotoxicant, the concept that VC modifies sensitivity of the liver to other factors, such as nonalcoholic fatty liver disease (NAFLD) caused by high-fat diet (HFD) is novel. This protocol describes an exposure paradigm to evaluate the effects of chronic, low-level exposure to VC. Read More

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http://dx.doi.org/10.3791/60351DOI Listing
January 2020

Quality Standards of Nursing Care for the Use of Chemical Restraints: A Realist Review.

J Nurs Care Qual 2020 Jan 16. Epub 2020 Jan 16.

Faculty of Nursing, University of Montreal, Quebec, Canada (Ms Hupé and Dr Larue and Ms Pépin); School of Nursing, University of Victoria, British Columbia, Canada (Dr Contandriopoulos); and CIUSSS de l'Est-de-l'Île-de-Montreal: Control Measures Research Center/Center for Nursing Excellence, Quebec, Canada (Ms Hupé and Dr Larue and Ms Gazemar).

Background: The use of chemical restraints (CRs) in health care facilities is a complex intervention that raises questions about its effectiveness and whether it is safe and patient oriented.

Purpose: This review aims to gather nursing quality standards for the use of CR through an innovative method of knowledge synthesis, the realist review, to support the development of a quality evaluation tool.

Methods: A realist review method was chosen. Read More

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http://dx.doi.org/10.1097/NCQ.0000000000000453DOI Listing
January 2020

Organic Light-Emitting Diode Employing Metal-Free Organic Phosphor.

ACS Appl Mater Interfaces 2020 Feb 21;12(5):6137-6143. Epub 2020 Jan 21.

Department of Chemistry , University of Michigan , Ann Arbor , Michigan 48109 , United States.

Metal-free organic phosphorescent materials are promising alternatives to the organometallic counterparts predominantly adopted in organic light-emitting diodes due to their low cost, chemical stability, and large molecular design window. However, only a few reports on OLED devices incorporating metal-free organic phosphors have been presented due to the lack of understanding on material properties, device physics, and device fabrication processes. Here, we report a tailor-designed novel fluorene-based organic phosphor with efficient spin-orbit coupling activated by bromine, aromatic carbonyl, and spiro-annulated phenyl moieties. Read More

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http://dx.doi.org/10.1021/acsami.9b20181DOI Listing
February 2020

Downsizing Class II Lasso Peptides: Genome Mining-Guided Isolation of Huascopeptin Containing the First Gly1-Asp7 Macrocycle.

J Org Chem 2020 Feb 23;85(3):1661-1667. Epub 2020 Jan 23.

Centre for Biotechnology and Bioengineering, CeBiB, Department of Chemical Engineering, Biotechnology and Materials , University of Chile , Beauchef 851 , Santiago 8370450 , Chile.

A new lasso peptide, huascopeptin, was isolated following genome-mined discovery of a new biosynthetic gene cluster in extremotolerant HST28 from Salar de Huasco, Atacama Desert, Chile. Compound is a 13-residue class II lasso peptide containing a novel Gly1-Asp7 macrolactam ring, a three-residue loop, and a three-residue tail, making it the smallest lasso peptide isolated to date. The lasso structure was confirmed using NOE restraint-based molecular dynamics simulations. Read More

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http://dx.doi.org/10.1021/acs.joc.9b02231DOI Listing
February 2020
4.721 Impact Factor

COMPARISON OF SUBCUTANEOUS ADMINISTRATION OF ALFAXALONE-MIDAZOLAM-DEXMEDETOMIDINE WITH KETAMINE-MIDAZOLAM-DEXMEDETOMIDINE FOR CHEMICAL RESTRAINT IN JUVENILE BLUE POISON DART FROGS ().

J Zoo Wildl Med 2020 Jan;50(4):868-873

Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.

Blue poison dart frogs () are commonly maintained in zoological institutions and are becoming popular in the pet trade industry. Sedation or light anesthesia is required for safe and effective handling of this species. In this study, the sedative effects of subcutaneously administered alfaxalone-midazolam-dexmedetomidine (AMD) (20, 40, 5 mg/kg, respectively) and ketamine-midazolam-dexmedetomidine (KMD) (100, 40, 5 mg/kg, respectively) were compared in a prospective, randomized, blinded, crossover study in juvenile blue poison dart frogs ( = 10). Read More

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http://dx.doi.org/10.1638/2019-0033DOI Listing
January 2020

Reconciling Simulated Ensembles of Apomyoglobin with Experimental Hydrogen/Deuterium Exchange Data Using Bayesian Inference and Multiensemble Markov State Models.

J Chem Theory Comput 2020 Feb 23;16(2):1333-1348. Epub 2020 Jan 23.

Department of Chemistry , Temple University , Philadelphia , Pennsylvania 19122 , United States.

Hydrogen/deuterium exchange (HDX) is a powerful technique to investigate protein conformational dynamics at amino acid resolution. Because HDX provides a measurement of solvent exposure of backbone hydrogens, ensemble-averaged over potentially slow kinetic processes, it has been challenging to use HDX protection factors to refine structural ensembles obtained from molecular dynamics simulations. This entails dual challenges: (1) identifying structural observables that best correlate with backbone amide protection from exchange and (2) restraining these observables in molecular simulations to model ensembles consistent with experimental measurements. Read More

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http://dx.doi.org/10.1021/acs.jctc.9b01240DOI Listing
February 2020

Neuropeptide S-initiated sequential cascade mediated by OX, NK, mGlu and CB receptors: a pivotal role in stress-induced analgesia.

J Biomed Sci 2020 Jan 9;27(1). Epub 2020 Jan 9.

Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan.

Background: Stress-induced analgesia (SIA) is an evolutionarily conserved phenomenon during stress. Neuropeptide S (NPS), orexins, substance P, glutamate and endocannabinoids are known to be involved in stress and/or SIA, however their causal links remain unclear. Here, we reveal an unprecedented sequential cascade involving these mediators in the lateral hypothalamus (LH) and ventrolateral periaqueductal gray (vlPAG) using a restraint stress-induced SIA model. Read More

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http://dx.doi.org/10.1186/s12929-019-0590-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950992PMC
January 2020

Purpurin exerted antidepressant-like effects on behavior and stress axis reactivity: evidence of serotonergic engagement.

Psychopharmacology (Berl) 2020 Mar 3;237(3):887-899. Epub 2020 Jan 3.

Department of Pharmacology, Ningbo University, School of Medical Science, Ningbo, China.

Rationale And Objectives: Major depression represents a significant public health problem worldwide, and effective regimen is lacking. The present study investigated the antidepressant-like effects of purpurin, a natural anthraquinone compound from Rubia tinctorum L., and explored the underlying mechanism(s). Read More

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http://dx.doi.org/10.1007/s00213-019-05422-wDOI Listing

Agglomeration mechanism and restraint measures of SiO nanoparticles in meta-aramid fibers doping modification via molecular dynamics simulations.

Nanotechnology 2020 Apr 30;31(16):165702. Epub 2019 Dec 30.

College of Engineering and Technology, Southwest University, Chongqing 400715, People's Republic of China.

In this work, the nanoparticle agglomeration process has been studied via molecular dynamics simulations to uncover the agglomeration mechanism. When the nanoparticles were far from each other in an aqueous solution, they mainly diffused because of influence of water molecules. When nanoparticles were close to each other, hydrogen bonds between the nanoparticles actively contributed to their agglomeration. Read More

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http://dx.doi.org/10.1088/1361-6528/ab662cDOI Listing

Post-traumatic stress disorder or emergence phenomena? A case of psychomotor agitation after procedural sedation and analgesia.

Drug Metab Pers Ther 2019 12;34(4)

Tehran University of Medical Sciences, Tehran, Iran.

Background Psychomotor agitation can be problematic in an overcrowded emergency department (ED) during uncontrolled procedural sedation. Although emergence phenomena have been studied, various presentations may exist. Case presentation During procedural sedation, a 58-year-old man was sedated with a dissociative dose of ketamine in conjunction with propofol. Read More

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http://dx.doi.org/10.1515/dmpt-2019-0024DOI Listing
December 2019

Using NMR Chemical Shifts and Cryo-EM Density Restraints in Iterative Rosetta-MD Protein Structure Refinement.

J Chem Inf Model 2020 May 24;60(5):2522-2532. Epub 2019 Dec 24.

Department of Chemistry and Biochemistry, Ohio State University, Columbus, Ohio 43210, United States.

Cryo-EM has become one of the prime methods for protein structure elucidation, frequently yielding density maps with near-atomic or medium resolution. If protein structures cannot be deduced unambiguously from the density maps, computational structure refinement tools are needed to generate protein structural models. We have previously developed an iterative Rosetta-MDFF protocol that used cryo-EM densities to refine protein structures. Read More

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http://dx.doi.org/10.1021/acs.jcim.9b00932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262651PMC

Prevalence of the use of chemical restraint in the management of challenging behaviours associated with adult mental health conditions: A meta-synthesis.

J Psychiatr Ment Health Nurs 2019 Dec 22. Epub 2019 Dec 22.

College of Nursing and Health Sciences, Flinders University, Adelaide, SA, Australia.

WHAT IS KNOWN ON THE SUBJECT?: The use of chemical restraint in emergency situations is to control aggression or violence to protect consumers and staff and is to be used as a last resort when all other behavioural control alternatives have been exhausted. Chemical restraint involves the use of medication. WHAT THE PAPER ADDS TO EXISTING KNOWLEDGE?: This is the first paper to systematically review the prevalence of the use of chemical restraint. Read More

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http://dx.doi.org/10.1111/jpm.12585DOI Listing
December 2019
0.978 Impact Factor

The discovery of potent and stable short peptide FGFR1 antagonist for cancer therapy.

Eur J Pharm Sci 2020 Feb 10;143:105179. Epub 2019 Dec 10.

The First affiliated hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. Electronic address:

Fibroblast growth factor receptor 1 (FGFR1) is one of the attractive pharmaceutical targets for cancer therapy. The FGFR1 targeting antagonist peptides, especially of the short peptides harbouring only coding amino acid might highlights promising aspects for their higher affinity, specificity and lower adverse reactions. However, most of peptides inhibitors remain in preclinical research, likely associating with their instability and short half-life. Read More

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http://dx.doi.org/10.1016/j.ejps.2019.105179DOI Listing
February 2020

Combined liquid hot water with sodium carbonate-oxygen pretreatment to improve enzymatic saccharification of reed.

Bioresour Technol 2020 Feb 29;297:122498. Epub 2019 Nov 29.

School of Light Industry and Chemical Engineering, Dalian Polytechnic University, Dalian 116034, Liaoning, China. Electronic address:

In this work, two-stage combination of liquid hot water (LHW) and NaCO-O pretreatment was performed efficiently on reed to obtain fermentable sugar. Reed was first treated with LHW at 170 °C for 60 min and then with NaCO-O. The optimal conditions for NaCO-O pretreatment were as follow: reaction temperature of 150 °C, residence time of 40 min, NaCO concentration of 33. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.122498DOI Listing
February 2020

A missed opportunity to improve practice around the use of restraints and consent in residential aged care: Limitations of the Quality of Care Amendment (Minimising the Use of Restraints) Principles 2019.

Australas J Ageing 2019 Dec 5. Epub 2019 Dec 5.

Capacity Australia, Sydney, New South Wales, Australia.

Objective: To explore the meaning and potential role of new Quality of Care Amendment (Minimising the Use of Restraints) Principles 2019, (Principles) which amend Quality of Care Principles 2014 in improving practice around physical and chemical restraint.

Methods: We examined both Principles and accompanying Explanatory Statement in light of best practices around consent and use of chemical and physical restraint.

Results: The chemical restraint definition is problematic by exclusion of medications for treating mental disorders, physical illness or physical conditions, which is not considered restraint. Read More

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http://dx.doi.org/10.1111/ajag.12757DOI Listing
December 2019

Conformation-dependent restraints for polynucleotides: the sugar moiety.

Nucleic Acids Res 2020 01;48(2):962-973

Center for Biocrystallographic Research, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan 61-704, Poland.

Stereochemical restraints are commonly used to aid the refinement of macromolecular structures obtained by experimental methods at lower resolution. The standard restraint library for nucleic acids has not been updated for over two decades and needs revision. In this paper, geometrical restraints for nucleic acids sugars are derived using information from high-resolution crystal structures in the Cambridge Structural Database. Read More

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http://dx.doi.org/10.1093/nar/gkz1122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954431PMC
January 2020
5 Reads

Doping the Smallest Shannon Radii Transition Metal Ion Ni(II) for Stabilizing α-CsPbI Perovskite Nanocrystals.

J Phys Chem Lett 2019 Dec 10;10(24):7916-7921. Epub 2019 Dec 10.

School of Materials Sciences , Indian Association for the Cultivation of Science , Kolkata 700032 , India.

Red emitting α-CsPbI nanocrystals are highly phase sensitive to ambient exposure, and B-site doping with suitable cations is adopted as one of the most feasible approaches for their phase stability. There are several reports herein: Ni(II) ions having the smallest transition metal Shannon radii were explored for doping in these nanocrystals. This successfully stabilized the cubic phase and retained the intense emission of nanocrystals for nearly 2 months. Read More

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http://dx.doi.org/10.1021/acs.jpclett.9b03306DOI Listing
December 2019
7.458 Impact Factor

Restrictive interventions in Victorian emergency departments: A study of current clinical practice.

Emerg Med Australas 2020 Jun 26;32(3):393-400. Epub 2019 Nov 26.

Emergency Department, Ballarat Hospital, Ballarat, Victoria, Australia.

Objective: To determine current clinical practices for managing behavioural emergencies within Victorian public hospital EDs.

Methods: A multi-centre retrospective study involving all patients who attended ED in 2016 at the Alfred, Ballarat, Dandenong, Geelong and Royal Melbourne Hospitals. The primary outcome was the rate of patient presentations with at least one restrictive intervention. Read More

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http://dx.doi.org/10.1111/1742-6723.13412DOI Listing

Molecular Detection of Feline Leukemia Virus in Oral, Conjunctival, and Rectal Mucosae Provides Results Comparable to Detection in Blood.

J Clin Microbiol 2020 Jan 28;58(2). Epub 2020 Jan 28.

Laboratório de Retroviroses, Departamento de Medicina Veterinária Preventiva, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

Feline leukemia virus (FeLV) infection causes immunosuppression, degeneration of the hematopoietic system, and fatal neoplasms. FeLV transmission occurs mainly by close social contact of infected and susceptible cats. Developing procedures for the diagnosis of feline retroviruses is crucial to reduce negative impacts on cat health and increase the number of animals tested. Read More

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http://dx.doi.org/10.1128/JCM.01233-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989071PMC
January 2020

One water-soluble polysaccharide from Ginkgo biloba leaves with antidepressant activities via modulation of the gut microbiome.

Food Funct 2019 Dec;10(12):8161-8171

Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi, China.

Depression, a mental illness characterized by persistent feeling of sadness and loss of interest, has been a serious health problem worldwide. Manipulation of the microbiota by probiotics and prebiotics represents a novel emerging strategy for the treatment of various psychiatric disorders such as major depressive disorders. Here, we show that one water-soluble polysaccharide from Ginkgo biloba leaves (GPS) reduced stress-induced depression and reversed gut dysbiosis. Read More

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http://dx.doi.org/10.1039/c9fo01178aDOI Listing
December 2019

Delayed evoked potentials in zebra finch () under midazolam-butorphanol-isoflurane anesthesia.

PeerJ 2019 24;7:e7937. Epub 2019 Oct 24.

Department of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan.

Avian animals are visually inclined, which has caused them to attract increasing attention for visual neurophysiology or electrophysiology studies, including the study of the visual evoked potential (VEP). VEP has developed into an investigative tool for understanding the physiology and the pathology of the visual pathway. Chemical restraint is a common method to minimize motion artifacts in animals when acquiring VEP data, but little is known about its influence on the signal in an avian animal. Read More

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http://dx.doi.org/10.7717/peerj.7937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815651PMC
October 2019

Editorial: Reducing Aggressive Episodes in Psychiatrically Hospitalized Children: Does Behavior Modification Work?

Authors:
A Reese Abright

J Am Acad Child Adolesc Psychiatry 2020 May 23;59(5):590-591. Epub 2019 Oct 23.

Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

Aggressive behaviors not manageable at home, school, or in other community settings constitute one of the major reasons for psychiatric hospitalization of children, but reduction and prevention of such behaviors in inpatient settings remain elusive goals. Strategies with varying degrees of success have ranged from reliance on therapeutic milieu as a positive treatment agent in and of itself to psychotherapeutic, behavioral, and psychopharmacological approaches targeted to specific disorders. Challenges include the diverse biologic, psychological, familial, environmental, and diagnostic factors that may be associated with aggressive episodes; limitations in adapting evidence-based, disorder-specific treatments developed in non-inpatient or specialized settings (for example, for individuals with autism spectrum disorder and other developmental disabilities) to the contingencies of 24-hour care in general inpatient units; and implementation of interventions such as time-outs, manual holds, and PRN and STAT medications for agitation in the context of current Joint Commission standards for seclusion, restraint (physical and chemical), and behavior management. Read More

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http://dx.doi.org/10.1016/j.jaac.2019.10.009DOI Listing

The "CHROME criteria": Tool to optimize and audit prescription quality of psychotropic medications in institutionalized people with dementia.

Int Psychogeriatr 2020 Mar;32(3):315-324

Maria Wolff Foundation, Madrid, Spain.

Objective: Describe and validate the CHROME (CHemical Restraints avOidance MEthodology) criteria.

Design: Observational prospective longitudinal study.

Setting: Single nursing home in Las Palmas de Gran Canaria, Spain. Read More

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http://dx.doi.org/10.1017/S104161021900111XDOI Listing

A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function.

J Exp Med 2019 12 10;216(12):2778-2799. Epub 2019 Oct 10.

Genetics and Rare Diseases Research Division, Ospedale Pediatrico Bambino Gesù, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy

Hemophagocytic lymphohistiocytosis (HLH) is characterized by immune dysregulation due to inadequate restraint of overactivated immune cells and is associated with a variable clinical spectrum having overlap with more common pathophysiologies. HLH is difficult to diagnose and can be part of inflammatory syndromes. Here, we identify a novel hematological/autoinflammatory condition (NOCARH syndrome) in four unrelated patients with superimposable features, including neonatal-onset cytopenia with dyshematopoiesis, autoinflammation, rash, and HLH. Read More

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http://dx.doi.org/10.1084/jem.20190147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888978PMC
December 2019
6 Reads

Characteristics and Severity of Agitation Associated With Use of Sedatives and Restraints in the Emergency Department.

J Emerg Med 2019 Nov 5;57(5):611-619. Epub 2019 Oct 5.

Department of Emergency Medicine, Yale School of Medicine, New Haven, Connecticut; Yale School of Public Health, New Haven, Connecticut.

Background: Agitated patients frequently present to emergency departments, but limited evidence exists regarding clinical decisions to use chemical sedatives and physical restraints.

Objective: We examined attributes and levels of agitation impacting thresholds for sedative and restraint use in the emergency setting.

Methods: This was a secondary study focusing on agitation characteristics within a prospective observational study of agitated patients in the emergency department at an urban, tertiary referral center. Read More

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http://dx.doi.org/10.1016/j.jemermed.2019.07.019DOI Listing
November 2019
1 Read
1.175 Impact Factor

[Pharmacological Effects of Yokukansankachimpihange on Urinary Catecholamine in Restraint-stressed Mice].

Yakugaku Zasshi 2019 ;139(10):1305-1312

Kampo Research Laboratories, Kracie Pharma Ltd.

Herbal medicines, acupuncture and moxibustion are often used for unidentified complaints. It is well known that catecholamine secreted by the sympatho-adrenal medullary system primarily functions to increase cardiac output and raise glucose levels in the blood during acute stress. In the present study, the effects of yokukansankachimpihange (YKSKCH, a Kampo medicine) on urinary catecholamine in mice that were repeatedly stressed by restraining were examined. Read More

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http://dx.doi.org/10.1248/yakushi.19-00013DOI Listing

Echocardiographic evaluation of four giant Aldabra tortoises ().

Vet Rec Open 2019 8;6(1):e000274. Epub 2019 Sep 8.

Il Mondo degli Animali Esotici, Genoa, Italy.

Objectives: In recent years echocardiography has become a good diagnostic tool in Zoo Medicine but in some cases, it is still a challenge. In Aldabra giant tortoise () the big size of animals and the few individuals hosted in Zoo are critical points for the application of this diagnostic technique.The purposes of this research were: to evaluate the feasibility of the diagnostic imaging technique on big-sized turtles; to define the echographic parameters for this species; and to describe the morphofunctional and physiological echographic characteristics of their cardiovascular system. Read More

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http://dx.doi.org/10.1136/vetreco-2018-000274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746541PMC
September 2019
2 Reads