947 results match your criteria Chemical Restraint


A Hybrid Hamiltonian for the Accelerated Sampling along Experimental Restraints.

Int J Mol Sci 2019 Jan 16;20(2). Epub 2019 Jan 16.

Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Průmyslová 595, 252 50 Vestec, Prague West, Czech Republic.

In this article, we present an enhanced sampling method based on a hybrid Hamiltonian which combines experimental distance restraints with a bias dependent from multiple path-dependent variables. This simulation method determines the bias-coordinates and does not require knowledge about reaction coordinates. The hybrid Hamiltonian accelerates the sampling of proteins, and, combined with experimental distance information, the technique considers the restraints adaptively and in dependency of the system's intrinsic dynamics. Read More

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http://dx.doi.org/10.3390/ijms20020370DOI Listing
January 2019

High-Throughput Video Processing of Heart Rate Responses in Multiple Wild-type Embryonic Zebrafish per Imaging Field.

Sci Rep 2019 Jan 15;9(1):145. Epub 2019 Jan 15.

National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC, USA.

Heart rate assays in wild-type zebrafish embryos have been limited to analysis of one embryo per video/imaging field. Here we present for the first time a platform for high-throughput derivation of heart rate from multiple zebrafish (Danio rerio) embryos per imaging field, which is capable of quickly processing thousands of videos and ideal for multi-well platforms with multiple fish/well. This approach relies on use of 2-day post fertilization wild-type embryos, and uses only bright-field imaging, circumventing requirement for anesthesia or restraint, costly software/hardware, or fluorescently-labeled animals. Read More

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http://dx.doi.org/10.1038/s41598-018-35949-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333808PMC
January 2019

Cochlospermum regium (Mart. ex Schrank) Pilg.: Evaluation of chemical profile, gastroprotective activity and mechanism of action of hydroethanolic extract of its xylopodium in acute and chronic experimental models.

J Ethnopharmacol 2019 Jan 3;233:101-114. Epub 2019 Jan 3.

Área de Farmacologia, Departamento de Ciências Básicas em Saúde, Faculdade de Medicina, Universidade Federal de Mato Grosso (UFMT), Cuiabá, Brazil. Electronic address:

Ethnopharmacological Relevance: Cochlospermum regium (Bixaceae) is a native shrub of Brazil and its xylopodium (infusion/decoction) is being used for the treatment of gastritis, ulcers, arthritis, intestinal infections, gynaecological infections, skin diseases, among others. The aim of the present study was to evaluate the gastroprotective/antiulcer activity and the mechanism of action of hydroethanolic extract of C. regium xylopodium (HECr), using in vitro and in vivo models. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03788741183292
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http://dx.doi.org/10.1016/j.jep.2019.01.002DOI Listing
January 2019
4 Reads

Factors associated with boarding and length of stay for pediatric mental health emergency visits.

Am J Emerg Med 2018 Dec 23. Epub 2018 Dec 23.

Division of Emergency Medicine, Boston Children's Hospital, 300 Longwood Ave., Boston, MA, United States of America. Electronic address:

Objective: To determine demographic and clinical risk factors associated with boarding (length of stay ≥24 h) for pediatric mental health emergency department (ED) visits.

Methods: This is a retrospective cross-sectional analysis of mental health visits identified by diagnosis codes for children 5-18 years old presenting to a tertiary pediatric ED in 2016. We performed multivariate logistic regression to identify demographic and clinical factors associated with boarding. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07356757183100
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http://dx.doi.org/10.1016/j.ajem.2018.12.041DOI Listing
December 2018
2 Reads

REPEATED ANESTHESIA IN A BLACK RHINOCEROS ( DICEROS BICORNIS) TO MANAGE UPPER RESPIRATORY OBSTRUCTION.

J Zoo Wildl Med 2018 Dec;49(4):1041-1046

This report describes weekly repeated anesthesia in a 7-yr-old, 1,030 kg, female Eastern black rhinoceros ( Diceros bicornis michaeli), that was immobilized six times using a combination of 2 mg etorphine (0.002 mg/kg), 5 mg medetomidine (0.005 mg/kg), 25 mg midazolam (0. Read More

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http://dx.doi.org/10.1638/2018-0095.1DOI Listing
December 2018

Psychiatric Considerations Regarding Prehospital Administration of Ketamine for Agitation.

J Nerv Ment Dis 2019 Jan;207(1):43-44

Department of Psychiatry, Saint Louis University School of Medicine, Saint Louis, MO.

Recently, ketamine has seen increased use among emergency medical services in the prehospital setting as a first-line means of chemical restraint for agitated patients. In this case report, we explore an instance in which ketamine administration for nonpsychotic agitation before emergency department (ED) evaluation may have caused unexpected psychotic symptoms leading to a complicated ED course necessitating admission. As ketamine gains widespread use in the prehospital setting, the safety profile deserves reevaluation. Read More

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http://dx.doi.org/10.1097/NMD.0000000000000910DOI Listing
January 2019

Characterization and gonadal hormone regulation of a sexually dimorphic corticotropin-releasing factor receptor 1 cell group.

J Comp Neurol 2018 Nov 30. Epub 2018 Nov 30.

Department of Psychology, University at Albany, Albany, New York.

Corticotropin-releasing factor binds with high affinity to CRF receptor 1 (CRFR1) and is implicated in stress-related mood disorders such as anxiety and depression. Using a validated CRFR1-green fluorescent protein (GFP) reporter mouse, our laboratory recently discovered a nucleus of CRFR1 expressing cells that is prominent in the female rostral anteroventral periventricular nucleus (AVPV/PeN), but largely absent in males. This sex difference is present in the early postnatal period and remains dimorphic into adulthood. Read More

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http://dx.doi.org/10.1002/cne.24588DOI Listing
November 2018
3 Reads

Thread-based assay for quantitative small molecule analysis of mice tear fluid by capillary electrophoresis.

Anal Bioanal Chem 2019 Jan 20;411(2):329-338. Epub 2018 Nov 20.

Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, IL, 60607, USA.

Tear fluid plays blood-like roles in the cornea, and changes in its chemical composition may be reflective of ocular surface disease pathogenesis. Studies of mice tears are limited by the small volume available for collection and difficulty in obtaining representative samples. Here, we establish a non-invasive assay for small volume analysis of small molecules in mice tears that requires no pre-treatment of mice. Read More

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http://dx.doi.org/10.1007/s00216-018-1488-6DOI Listing
January 2019
5 Reads

Harnessing Cyanine Reactivity for Optical Imaging and Drug Delivery.

Acc Chem Res 2018 Dec 12;51(12):3226-3235. Epub 2018 Nov 12.

Chemical Biology Laboratory, Center for Cancer Research , National Cancer Institute , Frederick , Maryland 20850 , United States.

Optical approaches that visualize and manipulate biological processes have transformed modern biomedical research. An enduring challenge is to translate these powerful methods into increasingly complex physiological settings. Longer wavelengths, typically in the near-infrared (NIR) range (∼650-900 nm), can enable advances in both fundamental and clinical settings; however, suitable probe molecules are needed. Read More

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http://pubs.acs.org/doi/10.1021/acs.accounts.8b00384
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http://dx.doi.org/10.1021/acs.accounts.8b00384DOI Listing
December 2018
10 Reads

Administration of 5-HT-1B agonist ameliorates pseudodementia induced by depression in rats.

Pak J Pharm Sci 2018 Sep;31(5(Supplementary)):2179-2184

Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, Pakistan.

Major depressive disorder (MDD) is the leading cause of memory impairment in general population. The serotonin hypothesis provides a target model for the treatment of depression and depression-associated memory loss. 5-HT-1B receptor is suggested as a potential candidate in the pathophysiology of depressive illness. Read More

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September 2018
5 Reads
0.950 Impact Factor

Widespread emergency department access block: a human rights issue in Australia?

Australas Psychiatry 2018 Oct 31:1039856218810156. Epub 2018 Oct 31.

Professor of Psychiatry, the University of Melbourne, Melbourne, VIC, and; Chair of Psychiatry, St Vincent's Health, Melbourne, VIC, Australia.

Objective:: There are increasing demands on emergency psychiatrists with higher numbers of mental health presentations, and longer stays in emergency departments (EDs). Australia, like other English speaking countries, funds considerably lower numbers of psychiatric beds than average for Organisation for Economic Co-operation and Development (OECD) countries. Consequently, acute bed occupancy is high, and a bed is frequently unavailable when a person needs admission. Read More

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http://dx.doi.org/10.1177/1039856218810156DOI Listing
October 2018
0.560 Impact Factor

Conformational restraint as a strategy for navigating towards lysosomes.

Chem Commun (Camb) 2018 Oct;54(85):12010-12013

Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.

Using the conformational restraint strategy, we developed a hydrazonate-derived coumarin into a lysosome targeting probe for imaging native formaldehyde at the subcellular level. Using this probe, we observed the overproduction of formaldehyde in lysosomes when cells were treated with endoplasmic reticulum (ER) stress inducers, suggesting the involvement of formaldehyde in protein misfolding. Read More

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http://xlink.rsc.org/?DOI=C8CC06155F
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http://dx.doi.org/10.1039/c8cc06155fDOI Listing
October 2018
17 Reads

Endpoint-restricted adiabatic free energy dynamics approach for the exploration of biomolecular conformational equilibria.

J Chem Phys 2018 Aug;149(7):072316

Department of Chemistry, New York University, New York, New York 10003, USA.

A method for calculating the free energy difference between two structurally defined conformational states of a chemical system is developed. A path is defined using a previously reported collective variable that interpolates between two or more conformations, and a restraint is introduced in order to keep the system close to the path. The evolution of the system along the path, which typically presents a high free energy barrier, is generated using enhanced sampling schemes. Read More

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http://dx.doi.org/10.1063/1.5027479DOI Listing
August 2018
5 Reads

MicroRNA Profiling and Bioinformatics Target Analysis in Dorsal Hippocampus of Chronically Stressed Rats: Relevance to Depression Pathophysiology.

Front Mol Neurosci 2018 6;11:251. Epub 2018 Aug 6.

Laboratory of Neuroplasticity and Neurogenetics, Faculty of Chemical and Pharmaceutical Sciences, Department of Biochemistry and Molecular Biology, Universidad de Chile, Santiago, Chile.

Studies conducted in rodents subjected to chronic stress and some observations in humans after psychosocial stress, have allowed to establish a link between stress and the susceptibility to many complex diseases, including mood disorders. The studies in rodents have revealed that chronic exposure to stress negatively affects synaptic plasticity by triggering changes in the production of trophic factors, subunit levels of glutamate ionotropic receptors, neuron morphology, and neurogenesis in the adult hippocampus. These modifications may account for the impairment in learning and memory processes observed in chronically stressed animals. Read More

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00251
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http://dx.doi.org/10.3389/fnmol.2018.00251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088391PMC
August 2018
9 Reads

Outcomes of Prehospital Chemical Sedation With Ketamine Versus Haloperidol and Benzodiazepine or Physical Restraint Only.

Prehosp Emerg Care 2018 Aug 27:1-9. Epub 2018 Aug 27.

Objective: The goal of this study is to describe complications and outcomes of prehospital ketamine use for agitation as compared to other methods of physical or chemical restraint such as haloperidol plus benzodiazepine or physical restraint only.

Methods: We conducted a single-center retrospective review of patient encounters in which restraint was administered in the prehospital setting. At the beginning of our study window, only physical restraint was available to paramedics managing agitated patients but subsequently, haloperidol and benzodiazepines were introduced, followed by ketamine 2 years later. Read More

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https://www.tandfonline.com/doi/full/10.1080/10903127.2018.1
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http://dx.doi.org/10.1080/10903127.2018.1501445DOI Listing
August 2018
13 Reads

Chronic Hippocampal Abnormalities and Blunted HPA Axis in an Animal Model of Repeated Unpredictable Stress.

Front Behav Neurosci 2018 20;12:150. Epub 2018 Jul 20.

Roskamp Institute, Sarasota, FL, United States.

Incidence of post-traumatic stress disorder (PTSD) ranges from 3 to 30% in individuals exposed to traumatic events, with the highest prevalence in groups exposed to combat, torture, or rape. To date, only a few FDA approved drugs are available to treat PTSD, which only offer symptomatic relief and variable efficacy. There is, therefore, an urgent need to explore new concepts regarding the biological responses causing PTSD. Read More

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http://dx.doi.org/10.3389/fnbeh.2018.00150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062757PMC

Endocannabinoid regulation of homeostatic feeding and stress-induced alterations in food intake in male rats.

Br J Pharmacol 2018 Jul 26. Epub 2018 Jul 26.

Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.

Background And Purpose: Stress is known to reduce food intake. Many aspects of the stress response and feeding are regulated by the endocannabinoid system, but the roles of anandamide (AEA) and 2-arachidonoyl glycerol (2-AG) in stress-induced anorexia are unclear.

Experimental Approach: Effects of acute restraint stress on endocannabinoids were investigated in male Sprague-Dawley rats. Read More

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http://dx.doi.org/10.1111/bph.14453DOI Listing
July 2018
10 Reads

Central apelin administration and restraint stress induce hypothalamic cholecystokinin release via the APJ receptor.

J Neuroendocrinol 2018 Sep 30;30(9):e12635. Epub 2018 Aug 30.

Department of Physiology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.

Exposure to an acute stressor induces up-regulation of apelin and cholecystokinin (CCK) in the hypothalamic paraventricular nucleus (PVN), which is the key brain centre integrating the stress-induced alterations in neuroendocrine, autonomic and behavioural functions. We tested the hypothesis that the release of CCK from the PVN is increased by centrally administered or stress-induced up-regulated endogenous apelin via the APJ receptor. Additionally, the effect of hypothalamic CCK on autonomic outflow was investigated under basal and stressed conditions. Read More

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http://dx.doi.org/10.1111/jne.12635DOI Listing
September 2018
1 Read

Chemo-mapping and biochemical-modulatory and antioxidant/prooxidant effect of Galium verum extract during acute restraint and dark stress in female rats.

PLoS One 2018 3;13(7):e0200022. Epub 2018 Jul 3.

Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University, Cluj-Napoca, Romania.

Galium verum is a well-known medicinal plant which is used in various pathologies. G. verum extracts are characterized here using chromatography, where among the rich pool of phenolic acids of flavonoids two known anti-stress modulators, chlorogenic acid and rutin are identified in high quantities. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200022PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029781PMC
January 2019
5 Reads

Prevalence of physical restraint among ventilated intensive care unit patients.

Authors:
Mohammad Suliman

J Clin Nurs 2018 Oct 23;27(19-20):3490-3496. Epub 2018 Jul 23.

Community and Mental Health Nursing Department, Al al-Bayt University, Mafraq, Jordan.

Aims And Objectives: To investigate the prevalence of physical restraint among mechanically ventilated intensive care unit patients in Jordan and to identify predicting factors and consequences.

Background: Physical restraint has been widely used among intensive care unit patients in many countries. Despite the benefits it offers in protecting patients from disrupting their medical treatment, it has been reported that restraint has many physical and psychological adverse effects. Read More

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http://dx.doi.org/10.1111/jocn.14588DOI Listing
October 2018
10 Reads

Chemical restraint of adults with intellectual disability and challenging behaviour in Queensland, Australia: Views of statutory decision makers.

J Intellect Disabil 2018 Jan 1:1744629518782064. Epub 2018 Jan 1.

Queensland University of Technology, Australia.

Background: Psychotropic medication is widely prescribed to treat mental illness. However, it is controversial when used as a chemical restraint (CR) to manage challenging behaviours (CBs) of adults with intellectual disability (ID). CR has potentially negative consequences and affects human rights. Read More

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http://dx.doi.org/10.1177/1744629518782064DOI Listing
January 2018
12 Reads

Protein stabilization by tuning the steric restraint at the reverse turn.

Chem Sci 2018 May 24;9(20):4600-4609. Epub 2018 Apr 24.

Molecular Biophysics Unit , Indian Institute of Science , Bangalore 560012 , India . Email:

Reverse turns are solvent-exposed motifs in proteins that are crucial in nucleating β-sheets and drive the protein folding. The solvent-exposed nature makes reverse turns more amenable to chemical modifications than α-helices or β-sheets towards modulating the stability of re-engineered proteins. Here, we utilize van der Waals repulsive forces in tuning the steric restraint at the reverse turn. Read More

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http://dx.doi.org/10.1039/c7sc05163hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969505PMC

Restraint prevalence and perceived coercion among psychiatric inpatients from South India: A prospective study.

Asian J Psychiatr 2018 Aug 22;36:10-16. Epub 2018 May 22.

Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, 560029, India.

Background: The Indian Mental Health Care Act 2017 (MHCA -2017) advocates the duty to provide treatment in the least coercive manner. Little data exists on how Indian patients perceive coercion in medical settings.

Aims: To study the prevalence of restraint in a Indian psychiatric inpatient unit, and to examine the level of perceived coercion correlating to various forms of restraint. Read More

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http://dx.doi.org/10.1016/j.ajp.2018.05.024DOI Listing
August 2018
3 Reads

Physical enrichment enhances memory function by regulating stress hormone and brain acetylcholinesterase activity in rats exposed to restraint stress.

Life Sci 2018 Aug 28;207:42-49. Epub 2018 May 28.

Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi 75270, Pakistan. Electronic address:

To study the effects of stress on mental health activity is of great importance in neuropsychological studies as it may affect the lifelong performance related to brain and overall health and wellbeing of an individual. It is observed very often that exposure to stress during early life can alter the brain function which may reflect as cognitive disability. Impairment of memory is associated with increased oxidative stress which is due to enhanced production of free radicals that may lead to lipid peroxidation and disintegration of cell structure and functions. Read More

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http://dx.doi.org/10.1016/j.lfs.2018.05.049DOI Listing
August 2018
4 Reads

Delirium after cardiac surgery. Incidence, phenotypes, predisposing and precipitating risk factors, and effects.

Heart Lung 2018 Jul - Aug;47(4):408-417. Epub 2018 May 8.

Cardiac Surgery Intensive Care Unit, Trieste University Hospital, Strada di Fiume 447, Trieste, 34148, Italy.

Background: In cardiac surgical patients little is known about different phenotypes of delirium and how the symptoms fluctuate over time.

Objectives: Evaluate risk factors, incidence, fluctuations, phenotypic characteristics and impact on patients' outcomes of delirium.

Methods: Prospective longitudinal study. Read More

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http://dx.doi.org/10.1016/j.hrtlng.2018.04.005DOI Listing
May 2018
4 Reads
1.320 Impact Factor

Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake.

Neuropsychopharmacology 2018 08 5;43(9):1840-1850. Epub 2018 Apr 5.

Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.

Negative emotional states that are associated with excessive alcohol intake, particularly anxiety-like states, have been linked to opponent processes in the central nucleus of the amygdala (CeA), affecting stress-related transmitters and monoamines. This study extends these observations to include endocannabinoid signaling in alcohol-dependent animals. Rats and mice were exposed to chronic intermittent alcohol with vapor inhalation or liquid diet to induce dependence. Read More

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http://dx.doi.org/10.1038/s41386-018-0055-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046053PMC
August 2018
7 Reads

Prolonged restraint stressor exposure in outbred CD-1 mice impacts microbiota, colonic inflammation, and short chain fatty acids.

PLoS One 2018 9;13(5):e0196961. Epub 2018 May 9.

Center for Microbial Pathogenesis, The Research Institute, Nationwide Children's Hospital, Columbus, OH, United States of America.

Stressor-exposure has been shown to exacerbate inflammation and change the composition of the gastrointestinal microbiota; however stressor-induced effects on microbiota-derived metabolites and their receptors are unknown. Thus, bacterial-produced short chain fatty acids (SCFAs), as well as microbial community composition, were assessed in the colons of mice exposed to stress during infection with Citrobacter rodentium. Mice were exposed to overnight restraint on 7 consecutive nights, or left undisturbed as a control. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196961PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942810PMC
August 2018
10 Reads

Changing characteristics of a Psychiatric Emergency Care Centre. An eight year follow-up study.

Australas Psychiatry 2018 May 1:1039856218772252. Epub 2018 May 1.

Senior Lecturer, University of Sydney, Sydney Medical School - Nepean, Discipline of Psychiatry, Sydney/Penrith, NSW, Australia.

Objective: The objective of this study was to report changes in characteristics of admissions to an established Psychiatric Emergency Care Centre (PECC) eight years after its opening.

Method: Key clinical characteristics of admissions to the PECC were documented for 327 patients in 2015 and compared with the 477 patients in 2007, which is when the centre first opened. The characteristics of admission were evaluated using an audit of medical records from June to December in both 2007 and 2015. Read More

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http://dx.doi.org/10.1177/1039856218772252DOI Listing
May 2018
3 Reads

Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors.

Transl Psychiatry 2018 04 26;8(1):92. Epub 2018 Apr 26.

Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.

Recent studies have demonstrated anxiolytic potential of pharmacological endocannabinoid (eCB) augmentation approaches in a variety of preclinical models. Pharmacological inhibition of endocannabinoid-degrading enzymes, such as fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), elicit promising anxiolytic effects in rodent models with limited adverse behavioral effects, however, the efficacy of dual FAAH/MAGL inhibition has not been investigated. In the present study, we compared the effects of FAAH (PF-3845), MAGL (JZL184) and dual FAAH/MAGL (JZL195) inhibitors on (1) anxiety-like behaviors under non-stressed and stressed conditions, (2) locomotor activity and body temperature, (3) lipid levels in the brain and (4) cognitive functions. Read More

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http://dx.doi.org/10.1038/s41398-018-0141-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917016PMC

Placental glucocorticoid receptor and 11β-hydroxysteroid dehydrogenase-2 recruitment indicates impact of prenatal adversity upon postnatal development in mice.

Stress 2018 Apr 12:1-10. Epub 2018 Apr 12.

a Department of Molecular Biology , Ariel University , Ariel , Israel.

Prenatal stress may increase concentrations of maternal glucocorticoids, which restrict fetal growth, with variable impact upon postnatal development. Among key regulators of stress hormone effects are the glucocorticoid receptor (GR) and 11β-hydroxysteroid dehydrogenase-2 (11βHSD2), the enzyme that inactivates glucocorticoid. This study utilized mice selectively bred for social dominance (Dom) or submissiveness (Sub), respectively exhibiting resilience or sensitivity to stress, to test whether stress-induced alterations in placental GR and 11βHSD2 protein expression may mediate divergent effects of prenatal adversity upon postnatal development. Read More

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http://dx.doi.org/10.1080/10253890.2018.1460660DOI Listing
April 2018
6 Reads

Chemical tick control practices in southwestern and northwestern Uganda.

Ticks Tick Borne Dis 2018 05 15;9(4):945-955. Epub 2018 Mar 15.

National Research Center for Protozoan Diseases (NRCPD), Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro 080-8555, Hokkaido, Japan; Research Center for Global Agromedicine, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido 080-8555, Japan. Electronic address:

Tick acaricide failure is one of the leading challenges to cattle production in Uganda. To gain an understanding into the possible drivers of acaricide failure, this study characterized the current chemical tick control practices in the southwestern (Mbarara, Mitooma and Rukungiri districts) and northwestern (Adjumani district) regions of Uganda. A total of 85 farms participated in a survey that utilized a semi-structured questionnaire. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.03.009DOI Listing
May 2018
4 Reads

Thermal restraint of a bacterial exopolysaccharide of shallow vent origin.

Int J Biol Macromol 2018 Jul 27;114:649-655. Epub 2018 Mar 27.

Dept of Mathematical and Informatics Sciences, Physical Sciences and Earth Sciences of Messina University, Viale Ferdinando Stagno D' Alcontres 31, 98166 Messina, Italy; Le Studium Loire Valley Institute for Advanced Studies, 1 rue Dupanloup 45000, Orléans, France; Centre de Biophysique Moleculaire (CBM)-CNRS UPR 4301 du CNRS, rue Charles Sadron, 45071 Orleans CEDEX 2 France; Laboratoire Interfaces, Confinement, Matériaux et Nanostructures (ICMN) - UMR 7374 CNRS - Université d'Orléans, 1b rue de la Férollerie, CS 40059, 45071 Orléans cedex 2, France; Istituto Nazionale di Alta Matematica "F. Severi" - INDAM - Gruppo Nazionale per la Fisica Matematica - GNFMV, Piazzale Aldo Moro, 5, 00185 Roma, Italy.

To dynamically characterize the thermal properties of the fructose-rich exopolysaccharide (EPS1-T14), produced by the marine thermophilic Bacillus licheniformis T14, the Attenuated Total Reflectance Fourier Transform Infra-Red spectroscopy was coupled to variable temperature ranging from ambient to 80°C. The spectra were analyzed by the following innovative mathematical tools: i) non-ideal spectral deviation, ii) OH-stretching band frequency center shift, iii) spectral distance, and iv) wavelet cross-correlation analysis. The thermal restraint analysis revealed that the whole EPS1-T14 system possessed high stability until 80°C, and suggested that fucose was mainly involved in the EPS1-T14 thermal stability, whereas glucose was responsible for its molecular flexibility. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130183082
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http://dx.doi.org/10.1016/j.ijbiomac.2018.03.160DOI Listing
July 2018
11 Reads

[Restraints in Greek mental health services: Ethics, practice and costs].

Psychiatriki 2017 Oct-Dec;28(4):306-313

5th Department of Psychiatry, Mental Hospital of Attica, Athens, Greece.

The use of physical and mechanical restraints in mental health services in Greece arise many ethical and practical issues. The justification of the use of such procedures is rather controversial and subjective to scientific debate. The practice of restraint puts both patients and staff at risk for injury and death. Read More

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http://www.psychiatriki-journal.gr/index.php?option=com_cont
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http://dx.doi.org/10.22365/jpsych.2017.284.306DOI Listing
September 2018
1 Read

Use of radiography in small animal practice in the UK and Republic of Ireland in 2013.

Vet Rec 2018 02 31;182(8):225. Epub 2018 Jan 31.

School of Veterinary Medicine & Science, University of Nottingham, Nottingham, UK.

Radiography is an essential diagnostic tool in small animal practice. A major transition is currently underway from film screen to digital systems. However, there is limited published research detailing the use of radiography in practices in the UK and Republic of Ireland (ROI). Read More

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http://veterinaryrecord.bmj.com/lookup/doi/10.1136/vr.104670
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http://dx.doi.org/10.1136/vr.104670DOI Listing
February 2018
3 Reads

Investigating energy-based pool structure selection in the structure ensemble modeling with experimental distance constraints: The example from a multidomain protein Pub1.

Proteins 2018 May 9;86(5):501-514. Epub 2018 Feb 9.

School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore.

The structural variations of multidomain proteins with flexible parts mediate many biological processes, and a structure ensemble can be determined by selecting a weighted combination of representative structures from a simulated structure pool, producing the best fit to experimental constraints such as interatomic distance. In this study, a hybrid structure-based and physics-based atomistic force field with an efficient sampling strategy is adopted to simulate a model di-domain protein against experimental paramagnetic relaxation enhancement (PRE) data that correspond to distance constraints. The molecular dynamics simulations produce a wide range of conformations depicted on a protein energy landscape. Read More

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http://dx.doi.org/10.1002/prot.25468DOI Listing
May 2018
28 Reads

Quorum-sensing control of antibiotic resistance stabilizes cooperation in Chromobacterium violaceum.

ISME J 2018 05 26;12(5):1263-1272. Epub 2018 Jan 26.

Department of Molecular Biosciences, University of Kansas, Lawrence, KS, 66045, USA.

Many Proteobacteria use quorum sensing to regulate production of public goods, such as antimicrobials and proteases, that are shared among members of a community. Public goods are vulnerable to exploitation by cheaters, such as quorum sensing-defective mutants. Quorum sensing- regulated private goods, goods that benefit only producing cells, can prevent the emergence of cheaters under certain growth conditions. Read More

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http://dx.doi.org/10.1038/s41396-018-0047-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932061PMC
May 2018
3 Reads

Hematology and serum biochemistry of free-ranging and captive Sechuran foxes (Lycalopex sechurae).

Vet Clin Pathol 2018 Mar 24;47(1):29-37. Epub 2018 Jan 24.

Laboratory of Veterinary Epidemiology and Economics, School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru.

Background: Hematologic and serum biochemical reference values obtained from captive or free-ranging wildlife populations may not be comparable as there can be significant variations due to preanalytic and analytic differences, including methods of capture and restraint, overall management in captivity including diet and composition of animal groups, and analytic methods being used. Hematology and serum biochemistry have never been studied in captive or free-ranging populations of Sechuran foxes (Lycalopex sechurae).

Objectives: The purposes of the study were to determine hematologic and serum biochemical RI in Sechuran foxes and to explore differences in these variables related to sex and overall life circumstances. Read More

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http://dx.doi.org/10.1111/vcp.12568DOI Listing

Host-Tree Selection by the Invasive Argentine Ant (Hymenoptera: Formicidae) in Relation to Honeydew-Producing Insects.

J Econ Entomol 2018 02;111(1):319-326

Graduate School of Agriculture, Kindai University, Nakamachi, Nara, Japan.

The Argentine ant, Linepithema humile (Mayr; Hymenoptera: Formicidae), is one of the world's most hazardous invasive species, and thus its eradication from Japan is important. Physical and chemical controls can be expensive and cause strong adverse effects on local terrestrial ecosystems regardless of their high efficacy. Here, presence/absence of host-tree selection by Argentine ants was investigated to understand the ant-honeydew-producing insects interactions in order to develop new cultural controls compatible with biodiversity conservation. Read More

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https://academic.oup.com/jee/article/111/1/319/4797357
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http://dx.doi.org/10.1093/jee/tox351DOI Listing
February 2018
16 Reads

Role of TLR4 in the Modulation of Central Amygdala GABA Transmission by CRF Following Restraint Stress.

Alcohol Alcohol 2018 Nov;53(6):642-649

Department of Neuroscience, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA.

Aims: Stress induces neuroimmune responses via Toll-like receptor 4 (TLR4) activation. Here, we investigated the role of TLR4 in the effects of the stress peptide corticotropin-releasing factor (CRF) on GABAergic transmission in the central nucleus of the amygdala (CeA) following restraint stress.

Methods: Tlr4 knock out (KO) and wild-type rats were exposed to no stress (naïve), a single restraint stress (1 h) or repeated restraint stress (1 h per day for 3 consecutive days). Read More

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http://dx.doi.org/10.1093/alcalc/agx114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203127PMC
November 2018
2 Reads

Anxiety, neuroinflammation, cholinergic and GABAergic abnormalities are early markers of Gulf War illness in a mouse model of the disease.

Brain Res 2018 02 24;1681:34-43. Epub 2017 Dec 24.

Department of Veterans Affairs, VA Boston Healthcare System, 150 S Huntington Av, Boston, MA 02130, USA; Department of Neurology, Boston University School of Medicine, 72 E Concord St, Boston, MA 02118, USA. Electronic address:

Gulf War Illness (GWI) is a chronic disease that affects the 1991 Gulf War (GW) veterans for which treatment is lacking. It has been hypothesized that drugs used to protect military personnel from chemical attacks and insects during the war: pyridostigmine bromide (PB),N, N-diethyl-m-toluamide (DEET), and permethrin (PER) together with stress may have contributed collectively and synergistically to generate GWI. There is a need to find markers of pathology to be used in pre-clinical trials. Read More

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http://dx.doi.org/10.1016/j.brainres.2017.12.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971846PMC
February 2018
11 Reads

Ketamine in the Prehospital Environment: A National Survey of Paramedics in the United States.

Prehosp Disaster Med 2018 Feb 21;33(1):23-28. Epub 2017 Dec 21.

3Center for Trauma and Critical Care,Department of Surgery,George Washington University,Washington, DCUSA.

Background: Use of ketamine in the prehospital setting may be advantageous due to its potent analgesic and sedative properties and favorable risk profile. Use in the military setting has demonstrated both efficacy and safety for pain relief. The purpose of this study was to assess ketamine training, use, and perceptions in the civilian setting among nationally certified paramedics (NRPs) in the United States. Read More

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https://www.cambridge.org/core/product/identifier/S1049023X1
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http://dx.doi.org/10.1017/S1049023X17007142DOI Listing
February 2018
7 Reads

High-Confidence Protein-Ligand Complex Modeling by NMR-Guided Docking Enables Early Hit Optimization.

J Am Chem Soc 2017 12 30;139(49):17824-17833. Epub 2017 Nov 30.

Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.

Structure-based drug design is an integral part of modern day drug discovery and requires detailed structural characterization of protein-ligand interactions, which is most commonly performed by X-ray crystallography. However, the success rate of generating these costructures is often variable, in particular when working with dynamic proteins or weakly binding ligands. As a result, structural information is not routinely obtained in these scenarios, and ligand optimization is challenging or not pursued at all, representing a substantial limitation in chemical scaffolds and diversity. Read More

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http://dx.doi.org/10.1021/jacs.7b07171DOI Listing
December 2017
1 Read

Restraint use among selected hospitalized elderly patients in Cairo, Egypt.

BMC Res Notes 2017 Nov 28;10(1):633. Epub 2017 Nov 28.

Charles McC. Mathias Jr., National Study Center for Trauma and Emergency Medical Systems, University of Maryland School of Medicine, Baltimore, MD, USA.

Objective: This study's primary objective was to investigate the prevalence of physical and chemical restraint use in selected elderly hospitalized patients.

Results: This study was conducted in April 2014 in four major acute care hospitals. Trained data collectors assessed the use of physical and chemical restraint among all admitted elderly patients. Read More

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http://dx.doi.org/10.1186/s13104-017-2978-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704368PMC
November 2017
1 Read

Anaesthetic and cardiorespiratory effects of ketamine plus dexmedetomidine for chemical restraint in black capuchin monkeys (Sapajus nigritus).

N Z Vet J 2018 Mar 26;66(2):79-84. Epub 2017 Nov 26.

c Department of Clinical Studies, School of Veterinary Medicine , University of Passo Fundo , BR 285 , Passo Fundo , RS , Brazil.

Aims: To evaluate the quality of anaesthesia and cardiorespiratory effects of ketamine and two doses of dexmedetomidine in captive black capuchin monkeys (Sapajus nigritus) undergoing routine clinical examination.

Methods: Twenty-four animals undergoing routine clinical examination were enrolled in the study. Animals were briefly physically restrained and examined to ensure no obvious illness was present and that they were healthy. Read More

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http://dx.doi.org/10.1080/00480169.2017.1403975DOI Listing
March 2018
5 Reads

Improving care for patients with dementia in the recovery room.

Authors:
Helena Edis

Br J Nurs 2017 Nov;26(20):1102-1108

Recovery Staff Nurse, Nottingham University Hospitals NHS Trust.

Caring for patients with dementia emerging from general anaesthesia in the recovery room can be very challenging. Sedation is sometimes necessary in order to nurse patients effectively and avoid any negative consequences of poor post-anaesthetic care. No local or national guidelines could be found to suggest best nursing practice in this situation. Read More

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http://www.magonlinelibrary.com/doi/10.12968/bjon.2017.26.20
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http://dx.doi.org/10.12968/bjon.2017.26.20.1102DOI Listing
November 2017
3 Reads

A Method to Administer Agents to the Larynx in an Awake Large Animal.

J Speech Lang Hear Res 2017 11;60(11):3171-3176

Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN.

Purpose: This research note describes an adapted experimental methodology to administer an exogenous agent to the larynx and upper airway of awake animals. The exogenous agent could be a perturbation. In the current study, the agent was isotonic saline. Read More

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http://dx.doi.org/10.1044/2017_JSLHR-S-17-0040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945077PMC
November 2017
10 Reads

Can System Truncation Speed up Ligand-Binding Calculations with Periodic Free-Energy Simulations?

J Chem Inf Model 2017 11 10;57(11):2865-2873. Epub 2017 Nov 10.

Department of Theoretical Chemistry, Lund University, Chemical Centre , P.O. Box 124, SE-221 00 Lund, Sweden.

We have investigated whether alchemical free-energy perturbation calculations of relative binding energies can be sped up by simulating a truncated protein. Previous studies with spherical nonperiodic systems showed that the number of simulated atoms could be reduced by a factor of 26 without affecting the calculated binding free energies by more than 0.5 kJ/mol on average ( Genheden, S. Read More

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http://dx.doi.org/10.1021/acs.jcim.7b00324DOI Listing
November 2017
7 Reads

The mutual restraint effect between the expansion of Alternanthera philoxeroides (Mart.) Griseb and cadmium mobility in aquatic environment.

Ecotoxicol Environ Saf 2018 Feb 6;148:237-243. Epub 2017 Nov 6.

State Key Lab of Marine Environmental Science, Xiamen University, Xiamen 361102, China. Electronic address:

Alternanthera philoxeroides (Mart.) Griseb is one of the most malignant weeds in its invision habitats. While in the cadmium-contaminated aquatic environment, does A. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2017.10.032DOI Listing
February 2018
1 Read