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    Production and Optimization of Physicochemical Parameters of Cellulase Using Untreated Orange Waste by Newly Isolated Emericella variecolor NS3.
    Appl Biochem Biotechnol 2017 Aug 3. Epub 2017 Aug 3.
    Department of Biotechnology, Nanobioelectronics Laboratory, Delhi Technological University, Main Bawana Road, Delhi, 110042, India.
    Cellulase enzymes have versatile industrial applications. This study was directed towards the isolation, production, and characterization of cellulase enzyme system. Among the five isolated fungal cultures, Emericella variecolor NS3 showed maximum cellulase production using untreated orange peel waste as substrate using solid-state fermentation (SSF). Read More

    Histological case-control study of peeling-induced skin changes by different peeling agents in surgically subcutaneous undermined skin flaps in facelift patients.
    J Plast Reconstr Aesthet Surg 2017 Jun 27. Epub 2017 Jun 27.
    Center for Plastic and Aesthetic Surgery, Ocean Clinic Marbella, Spain.
    A histological evaluation of peeling-induced skin changes in subcutaneous undermined preauricular facial skin flaps of nine patients was performed. There were three treatment groups: Trichloroacetic acid (TCA) 25%, TCA 40% and phenol/croton oil; one group served as control. Two independent evaluators determined the epidermal and dermal thickness and the depth of necrosis (micrometre). Read More

    Melasma: an Up-to-Date Comprehensive Review.
    Dermatol Ther (Heidelb) 2017 Jul 19. Epub 2017 Jul 19.
    Ronald O. Perelman Department of Dermatology, New York University, New York, NY, USA.
    Melasma is a common acquired condition of symmetric hyperpigmentation, typically occurring on the face, with higher prevalence in females and darker skin types. Multiple etiologies, including light exposure, hormonal influences, and family history, have been implicated in the pathogenesis of this disorder. Overall prevalence ranges widely at 1-50%, since values are typically calculated within a specific ethnic population within a geographic region. Read More

    Production of ligninolytic enzymes and some diffusible antifungal compounds by white-rot fungi using potato solid wastes as the sole nutrient source.
    J Appl Microbiol 2017 Jul 18. Epub 2017 Jul 18.
    Department of Chemical Engineering, Universidad de La Frontera, Temuco, Chile.
    Aims: The aim of this study was to evaluate the synthesis of ligninolytic enzymes and some diffusible antifungal compounds by white-rot fungi using peels or discarded potato as the sole nutrient source.

    Methods And Results: The strain Trametes hirsuta Ru-513 has been highlighted for its laccase activity (595 ± 33 U l(-1) ), which is able to decolourise 87% of an anthraquinone dye using potato peels as the sole nutritional support. A native polyacrylamide gel of laccase proteins showed the presence of two isoenzymes, corresponding to proteins of 56 and 67 kDa, which were detected by SDS-PAGE. Read More

    Structures of antimutagenic constituents in the peels of Citrus limon.
    J Nat Med 2017 Jul 11. Epub 2017 Jul 11.
    Department of Public Health, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
    The methanolic extracts from the peels of Citrus limon were found to show antimutagenic effects against 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the Ames test. From the methanolic extracts, four new coumarins (wakayamalimonol A-D) and a new furanocoumarin (wakayamalimonol E) were isolated together with fifteen known compounds. The absolute stereostructures of the new compounds were determined by chemical synthesis and the modified Mosher's method. Read More

    Optimization of pectinase-assisted and tri-solvent-mediated extraction and recovery of lycopene from waste tomato peels.
    3 Biotech 2017 Jul 30;7(3):206. Epub 2017 Jun 30.
    Department of Food Technology, University Institute of Chemical Technology, North Maharashtra University, Jalgaon, 425001, India.
    In the present work, optimization of pectinase-assisted and tri-solvent-mediated extraction of lycopene from waste tomato peels was carried out. The optimized parameters for enzymatic pre-treatment were 2% pectinase concentration, pH 5.5, 4-h incubation, 45 °C and 150 rpm. Read More

    Isotretinoin and Timing of Procedural Interventions: A Systematic Review With Consensus Recommendations.
    JAMA Dermatol 2017 Aug;153(8):802-809
    Pennsylvania State University, Hershey.
    Importance: The notion that systemic isotretinoin taken within 6 to 12 months of cutaneous surgery contributes to abnormal scarring or delayed wound healing is widely taught and practiced; however, it is based on 3 small case series from the mid-1980s.

    Objective: To evaluate the body of literature to provide evidence-based recommendations regarding the safety of procedural interventions performed either concurrently with, or immediately following the cessation of systemic isotretinoin therapy.

    Evidence Review: A panel of national experts in pediatric dermatology, procedural/cosmetic dermatology, plastic surgery, scars, wound healing, acne, and isotretinoin was convened. Read More

    Dark-Fermentative Biological Hydrogen Production from Mixed Biowastes Using Defined Mixed Cultures.
    Indian J Microbiol 2017 Jun 9;57(2):171-176. Epub 2017 Mar 9.
    Microbial Biotechnology and Genomics, CSIR-Institute of Genomics and Integrative Biology (IGIB), Delhi University Campus, Mall Road, Delhi, 110007 India.
    Biological hydrogen (H2) production from the biowastes is widely recognized as a suitable alternative approach to utilize low cost feed instead of costly individual sugars. In the present investigation, pure and mixed biowastes were fermented by defined sets of mixed cultures for hydrolysis and H2 production. Under batch conditions, up to 65, 67 and 70 L H2/kg total solids (2%, TS) were evolved from apple pomace (AP), onion peels (OP) and potato peels (PP) using a combination of hydrolytic mixed culture (MHC5) and mixed microbial cultures (MMC4 or MMC6), respectively. Read More

    A Deceptively Simple Solution for Refractory Melasma: Glycolic Acid Peels and Hydroquinone at Home.
    Plast Reconstr Surg Glob Open 2017 May 19;5(5):e1335. Epub 2017 May 19.
    Department of Plastic Surgery, University of Tokyo School of Medicine, Tokyo, Japan; and Department of Plastic Surgery, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
    Although various treatment methods for melasma have developed, substantial improvement of the condition is sometimes difficult. We have experientially found that some of refractory melasma caused by daily friction can easily be treated by using a combination of a peeling agent (20% glycolic acid) and a depigmenting agent (5% hydroquinone) twice daily at home. And here, by performing skin biopsies, we revealed the pathological mechanism: hyperkeratosis caused by repeated physical stimulus, which prevents infiltration of topical therapeutic agents, was dramatically reduced by chemical peeling, resulting that the melanin pigments were effectively cleared by topical hydroquinone. Read More

    Anti-Inflammatory and Neuroprotective Constituents from the Peels of Citrus grandis.
    Molecules 2017 Jun 9;22(6). Epub 2017 Jun 9.
    School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
    A series of chromatographic separations performed on the ethanol extracts of the peels of Citrus grandis has led to the characterization of forty compounds, including seventeen coumarins, eight flavonoids, two triterpenoids, four benzenoids, two steroids, one lignan, one amide, and five other compounds, respectively. The chemical structures of the purified constituents were identified on the basis of spectroscopic elucidation, including 1D- and 2D-NMR, UV, IR, and mass spectrometric analysis. Most of the isolated compounds were examined for their inhibition of superoxide anion generation and elastase release by human neutrophils. Read More

    Nanocomposites based on banana starch reinforced with cellulose nanofibers isolated from banana peels.
    J Colloid Interface Sci 2017 May 26;505:154-167. Epub 2017 May 26.
    Department of Food Engineering, School of Animal Science and Food Engineering, University of São Paulo, CEP 13635-900 Pirassununga, SP, Brazil.
    Cellulose nanofibers were isolated from banana peel using a combination of chemical and mechanical treatments with different number of passages through the high-pressure homogenizer (0, 3, 5, and 7 passages). New nanocomposites were then prepared from a mixed suspension of banana starch and cellulose nanofibers using the casting method and the effect of the addition of these nanofibers on the properties of the resulting nanocomposites was investigated. The cellulose nanofibers homogeneously dispersed in the starch matrix increased the glass transition temperature, due to the strong intermolecular interactions occurring between the starch and cellulose. Read More

    Efficacy and safety of superficial chemical peeling in treatment of active acne vulgaris.
    An Bras Dermatol 2017 Mar-Apr;92(2):212-216
    Department of Biomedical Sciences and Therapeutics, Faculty of Medicine and Health Sciences, University Malaysia Sabah - Sabah, Malaysia.
    Acne vulgaris is an extremely common condition affecting the pilosebaceous unit of the skin and characterized by presence of comedones, papules, pustules, nodules, cysts, which might result in permanent scars. Acne vulgaris commonly involve adolescents and young age groups. Active acne vulgaris is usually associated with several complications like hyper or hypopigmentation, scar formation and skin disfigurement. Read More

    Oriented Growth of α-MnO₂ Nanorods Using Natural Extracts from Grape Stems and Apple Peels.
    Nanomaterials (Basel) 2017 May 22;7(5). Epub 2017 May 22.
    Department of Fiber Science and Apparel Design, Cornell University, Ithaca, NY 14853, USA.
    We report on the synthesis of alpha manganese dioxide (α-MnO₂) nanorods using natural extracts from Vitis vinifera grape stems and Malus domestica 'Cortland' apple peels. We used a two-step method to produce highly crystalline α-MnO₂ nanorods: (1) reduction of KMnO₄ in the presence of natural extracts to initiate the nucleation process; and (2) a thermal treatment to enable further solid-state growth of the nuclei. Transmission electron microscopy (TEM) and field emission scanning electron microscopy (FESEM) images provided direct evidence of the morphology of the nanorods and these images were used to propose nucleation and growth mechanisms. Read More

    ASDS Guidelines Task Force: Consensus Recommendations Regarding the Safety of Lasers, Dermabrasion, Chemical Peels, Energy Devices, and Skin Surgery During and After Isotretinoin Use.
    Dermatol Surg 2017 May 10. Epub 2017 May 10.
    *Department of Dermatology, Northwestern University, Chicago, Illinois; †Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; ‡Section of Dermatology, University of Chicago Medicine, Chicago, Illinois; §SkinCare Physicians, Chestnut Hill, Massachusetts; ‖Laser & Skin Surgery Center of New York, New York, New York; ¶Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York; #Union Square Laser Dermatology, New York, New York; **Laser and Skin Surgery Center of Northern California, Sacramento, California; ††Department of Dermatology, University of California Davis School of Medicine, Davis, California; ‡‡Department of Dermatology, University of California San Diego Health System, San Diego, California; §§DermOne, LLC, West Conshohocken, Pennsylvania; ‖‖Division of Dermatology, Section of Procedural Dermatology, Cooper University Health Care, Marlton, New Jersey; ¶¶Westlake Dermatology and Cosmetic Surgery, Austin, Texas; ##Division of Plastic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; ***Department of Dermatology, Naval Medical Center, San Diego, California; †††Department of Dermatology, Naval Hospital Camp Lejeune, Camp Lejeune, North Carolina; Departments of ‡‡‡Otolaryngology, and §§§Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
    Background: Currently, the isotretinoin (13-cis-retinoic acid) package insert contains language advising the discontinuation of isotretinoin for 6 months before performing cosmetic procedures, including waxing, dermabrasion, chemical peels, laser procedures, or incisional and excisional cold-steel surgery. It is common practice to follow this standard because of concerns regarding reports of sporadic adverse events and increased risk of scarring.

    Objective: To develop expert consensus regarding the safety of skin procedures, including resurfacing, energy device treatments, and incisional and excisional procedures, in the setting of concurrent or recent isotretinoin use. Read More

    Optimization of adsorption process parameters by response surface methodology for hexavalent chromium removal from aqueous solutions using Annona reticulata Linn peel microparticles.
    Water Sci Technol 2017 May;75(9):2094-2107
    Department of Chemical Engineering, National Institute of Technology Calicut, Calicut 673601, Kerala, India E-mail:
    Fruit peel microparticles of Annona reticulata Linn were used as biosorbent for the sequestration of hexavalent chromium (CR(VI)). Characterization of the biosorbent was done using scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDXS), Fourier transfer infrared spectroscopy (FTIR), gas chromatography-mass spectrometry (GCMS), carbon, hydrogen, nitrogen and sulphur (CHNS) elemental analysis, mercury intrusion porosimetry and point of zero charge. Influential parameters were optimized using response surface methodology (RSM) with a total of 17 experimental runs based on the Box-Behnken design and found to be pH 1. Read More

    A review of laser and light therapy in melasma.
    Int J Womens Dermatol 2017 Mar 21;3(1):11-20. Epub 2017 Mar 21.
    Department of Dermatology, Palo Alto Medical Foundation, Sunnyvale, California.
    Melasma is a dysregulation of the homeostatic mechanisms that control skin pigmentation and excess pigment is produced. Traditional treatment approaches with topical medications and chemical peels are commonly used but due to the refractory and recurrent nature of melasma, patients often seek alternative treatment strategies such as laser and light therapy. Several types of laser and light therapy have been studied in the treatment of melasma. Read More

    A review of the safety of cosmetic procedures during pregnancy and lactation.
    Int J Womens Dermatol 2017 Mar 27;3(1):6-10. Epub 2017 Feb 27.
    Department of Dermatology, University of California San Francisco, San Francisco, California.
    The safety of cosmetic procedures in patients who are pregnant and/or lactating is a complex clinical question surrounded by uncertainty. Our objective is to consolidate data on the safety of commonly requested cosmetic procedures during pregnancy and lactation after a systematic review of the current literature to guide evidence-based care in the future. A systematic search of the PubMed database was conducted for articles on cosmetic procedures during pregnancy and lactation. Read More

    Drought-Enhanced Xylem Sap Sulfate Closes Stomata by Affecting ALMT12 and Guard Cell ABA Synthesis.
    Plant Physiol 2017 Jun 26;174(2):798-814. Epub 2017 Apr 26.
    Professur für Baumphysiologie, Institut für Forstwissenschaften, Albert-Ludwigs-Universität Freiburg, 79110 Freiburg, Germany (F.M., J.K., D.R., C.H., H.R.).
    Water limitation of plants causes stomatal closure to prevent water loss by transpiration. For this purpose, progressing soil water deficit is communicated from roots to shoots. Abscisic acid (ABA) is the key signal in stress-induced stomatal closure, but ABA as an early xylem-delivered signal is still a matter of debate. Read More

    Mangiferin functionalized radioactive gold nanoparticles (MGF-(198)AuNPs) in prostate tumor therapy: green nanotechnology for production, in vivo tumor retention and evaluation of therapeutic efficacy.
    Dalton Trans 2017 Apr 25. Epub 2017 Apr 25.
    Nuclear Science and Engineering Institute (NSEI), Department of Radiology, Institute of Green Nanotechnology, University of Missouri Research Reactor (MURR), Harry S. Truman Memorial Veterans Hospital, Department of Physics, University of Missouri, One Hospital Drive, Columbia, MO 65212, USA.
    We report here an innovative feature of green nanotechnology-focused work showing that mangiferin-a glucose functionalized xanthonoid, found in abundance in mango peels-serves dual roles of chemical reduction and in situ encapsulation, to produce gold nanoparticles with optimum in vivo stability and tumor specific characteristics. The interaction of mangiferin with a Au-198 gold precursor affords MGF-(198)AuNPs as the beta emissions of Au-198 provide unique advantages for tumor therapy while gamma rays are used for the quantitative estimation of gold within the tumors and various organs. The laminin receptor specificity of mangiferin affords specific accumulation of therapeutic payloads of this new therapeutic agent within prostate tumors (PC-3) of human prostate tumor origin induced in mice which overexpress this receptor subtype. Read More

    Isolation of flavonoids from apple peel using novel graphene oxide cotton fiber.
    Nat Prod Res 2017 Apr 20:1-5. Epub 2017 Apr 20.
    d Faculty of Agriculture, Department of Plant, Food, and Environmental Sciences , Dalhousie University , Truro , NS , Canada.
    A novel graphene oxide cotton fibre (GOF) was used to adsorb flavonoids from crude ethanol extracts derived from apple peels. Ultra-high pressure liquid chromatography-mass spectrometry was used to analyse polyphenol content, and the resulting data demonstrated that GOF-based flash chromatography can be used to efficiently separate polyphenols from sugars and can facilitate the removal of 95% of the sugar content. Flavonoids can be easily separated from phenolic acids. Read More

    Improvement of Atrophic Acne Scars in Skin of Color Using Topical Synthetic Epidermal Growth Factor (EGF) Serum: A Pilot Study.
    J Drugs Dermatol 2017 Apr;16(4):322-326

    BACKGROUND: Atrophic scarring in skin of color is a common, permanent, and distressing result of uncontrolled acne vulgaris. Ablative lasers and chemical peels are frequently used to improve the appearance of atrophic scars, primarily through the stimulation of collagen and elastin; however, these treatment modalities are associated with risks, such as dyspigmentation and hypertrophic scarring, especially in patients with darker skin.

    OBJECTIVE: We evaluated the efficacy of topically applied synthetic epidermal growth factor (EGF) serum in reducing the appearance of atrophic acne scars in skin of color. Read More


    Combination of In-Office Chemical Peels With a Topical Comprehensive Pigmentation Control Product in Skin of Color Subjects With Facial Hyperpigmentation.
    J Drugs Dermatol 2017 Apr;16(4):301-306

    Dyschromia is one of the primary complaints for patients with skin of color. Treatments need to achieve a balance between tolerability and efficacy to address existing hyperpigmentation without causing additional damage that could trigger post-inflammatory hyperpigmentation (PIH). An open-label, single-center study was conducted to assess the efficacy of a novel comprehensive pigmentation control serum (LYT2) combined with a series of three very superficial chemical peels (VP) in skin of color subjects. Read More


    Agro-Industrial Wastes for Production of Biosurfactant by Bacillus subtilis ANR 88 and Its Application in Synthesis of Silver and Gold Nanoparticles.
    Front Microbiol 2017 24;8:492. Epub 2017 Mar 24.
    Department of Microbiology, Savitribai Phule Pune University Pune, India.
    Biosurfactants, surface-active amphiphilic compounds, despite having a wide range of applications, have a high cost of production, which severely restricts their use. For cheaper production of biosurfactant, we investigated the potential of the indigenously isolated biosurfactant producing organism, Bacillus subtilis ANR 88, to grow on different cheap carbon sources (molasses, whey, and extracts of potato peels, orange peels, banana peels, and bagasse). We found that, B. Read More

    2D-NMR investigation and in vitro evaluation of antioxidant, antigenotoxic and estrogenic/antiestrogenic activities of strawberry grape.
    Food Chem Toxicol 2017 Jul 27;105:52-60. Epub 2017 Mar 27.
    Dipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche (DiSTABiF), Università degli Studi della Campania "Luigi Vanvitelli", Via Vivaldi 43, I-81100 Caserta, Italy.
    Strawberry grape is considered beneficial due to its extensive phytochemical properties. To expand the knowledge about the chemical constituents and the biological activities of the whole plant, 2D-NMR investigation has been carried out on pulp, peel, seeds, stalks and leaves. Catechin and epicatechin were identified as the main constituents of the seed extract, quercetin and ferulic acid were detected in the leaves and malvidin and cyanidin glucopyranoside in the peels. Read More

    Review in peeling complications.
    J Cosmet Dermatol 2017 Mar 27. Epub 2017 Mar 27.
    Department of Dermatology, HUB, University of Brasilia, Brasilia, Brazil.
    Chemical peeling, a procedure wherein a chemical agent is applied to the skin to cause controlled destruction followed by regeneration and remodeling, is a dynamic tool for the treatment of acne, pigmentation issues, and photoaging [Journal of cutaneous and aesthetic surgery vol. 5 (2012) 254-260]. The results and complications are related to the depth of the procedure, with deeper peels producing more marked results and higher rates of complications. Read More

    Antioxidant activity and polyphenolic compound stability of lentil-orange peel powder blend in an extrusion process.
    J Food Sci Technol 2017 Mar 28;54(4):954-963. Epub 2016 Nov 28.
    Food Engineering and Technology Department, Institute of Chemical Technology (ICT), Deemed University, Matunga, Mumbai, 400 019 India ; Association of Food Scientists and Technologists, Mysore, India.
    Lentil contains substantial amount of protein, carbohydrate, fibre and other nutrients and orange peels powder rich in carbohydrate and fiber content The present study was aimed to investigate the effects of extrusion processing parameter on the level of total phenolic content (TPC), total flavonoid content (TFC), total tannin content and antioxidant activity of lentil-orange peel powder blend, also to investigate the possibility of blend as a candidate for production of protein rich extruded product by using response surface methodology. It was observed that, the physicochemical properties and sensory characteristics of lentil-orange peel based extrudate were highly dependent on process variables. The blend of lentil and orange peel powder has a huge potential for extrusion to produce ready-to-eat extruded with good acceptance. Read More

    Solution of Azelaic Acid (20%), Resorcinol (10%) and Phytic Acid (6%) Versus Glycolic Acid (50%) Peeling Agent in the Treatment of Female Patients with Facial Melasma.
    Adv Biomed Res 2017 22;6. Epub 2017 Feb 22.
    Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Melasma, a common acquired disorder of hyperpigmentation, especially in women, is often resistant to therapy. This study was aimed to evaluate the efficacy and safety of azelaic acid, resorcinol and phytic acid solution in chemical peeling of melasma in comparison to 50% glycolic acid.

    Materials And Methods: This clinical trial was performed, on 42 female patients with bilateral melasma. Read More

    Chemical peels in active acne and acne scars.
    Clin Dermatol 2017 Mar - Apr;35(2):179-182. Epub 2016 Oct 27.
    Department of Dermatology and Venereology, Andreas Sygros Skin Hospital, Athens, Greece. Electronic address:
    Chemical peeling is a widely used procedure in the management of acne and acne scars. It causes controlled destruction of a part of or the entire epidermis, with or without the dermis, leading to exfoliation and removal of superficial lesions, followed by regeneration of new epidermal and dermal tissues. The most frequently used peeling agents are salicylic acid, glycolic acid, pyruvic acid, lactic acid, mandelic acid, Jessner solution, trichloroacetic acid, and phenol. Read More

    Facile and scalable synthesis of magnetite/carbon adsorbents by recycling discarded fruit peels and their potential usage in water treatment.
    Bioresour Technol 2017 Jun 20;233:110-115. Epub 2017 Feb 20.
    Lab of Functional and Biomedical Nanomaterials, College of Materials Science and Engineering, Qingdao University of Science and Technology, China. Electronic address:
    In this study, apple, banana and orange peels were used as precursor compounds for the mass production of magnetite/carbon adsorbents. A so-called "soak-calcination" procedure was employed by firstly soaking these waste fruit peels in FeCl3 aqueous solutions and secondly calcining these precursors in the nitrogen atmosphere to yield final magnetite/carbon composites. This approach is quite simple and effective to synthesize carbon-based adsorbents on an industrial scale. Read More

    Fast Separation and Sensitive Quantitation of Polymethoxylated Flavonoids in the Peels of Citrus Using UPLC-Q-TOF-MS.
    J Agric Food Chem 2017 Mar 15;65(12):2615-2627. Epub 2017 Mar 15.
    Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University , Chongqing 400715, P. R. China.
    A rapid, sensitive, and efficient ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) method has been developed to analyze polymethoxylated flavonoids (PMFs) in 14 Citrus peels, including 7 Citrus reticulata (C. reticulata) and 7 Citrus sinensis (C. sinensis). Read More

    Effect of extraction condition on properties of pectin from banana peels and its function as fat replacer in salad cream.
    J Food Sci Technol 2017 Feb 9;54(2):386-397. Epub 2017 Jan 9.
    Food Science Unit, Institute of Nutrition, Mahidol University, Phutthamonthon 4 Road, Salaya, Phutthamonthon, Nakhon Pathom, 73170 Thailand.
    Banana peels are wasted from banana processing industry. Pectin is a soluble dietary fibre usually prepared from fruit and vegetable processing wastes. Pectin extraction from banana peels thus should be an effective way of waste utilization. Read More

    Melasma: systematic review of the systemic treatments.
    Int J Dermatol 2017 Sep 27;56(9):902-908. Epub 2017 Feb 27.
    Division of Dermatology, University of Toronto, Toronto, Ontario, Canada.
    Currently available treatment options for melasma include prevention of UV radiation, topical lightening agents, chemical peels, and light-based and laser therapies. However, none have shown effective and sustained results, with incomplete clearance and frequent recurrences. There has been increasing interest recently in oral medications and dietary supplements in improving melasma. Read More

    Dermal morphological changes following salicylic acid peeling and microdermabrasion.
    J Cosmet Dermatol 2017 Feb 22. Epub 2017 Feb 22.
    Faculty of Medicine, Department of Pathology, Assiut University, Assiut, Egypt.
    Background: Microdermabrasion and chemical peeling are popular, inexpensive, and safe methods for treatment of some skin disorders and to rejuvenate skin.

    Objectives: To study the alterations of the dermal connective tissue following salicylic acid peeling and microdermabrasion.

    Methods: Twenty patients were participated in our study. Read More

    Characterization of major metabolites of polymethoxylated flavonoids in Pericarpium Citri Reticulatae using liver microsomes immobilized on magnetic nanoparticles coupled with UPLC/MS-MS.
    Chem Cent J 2017 6;11:13. Epub 2017 Feb 6.
    Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041 Sichuan China.
    The peels of citrus fruits (Pericarpium Citri Reticulatae, PCR) have long been used in traditional Chinese medicines (TCMs). Polymethoxylated flavonoids (PMFs) were found to be the main components present in PCR extracts, but their metabolism remains unclear which restrain the utilization of this TCM. In the present work, rat liver microsomes were immobilized on magnetic nanoparticles (LMMNPs) for in vitro metabolic study on the whole PMFs of PCR. Read More

    A Case of Lichen Planus Pigmentosus with Facial Dyspigmentation Responsive to Combination Therapy with Chemical Peels and Topical Retinoids.
    J Clin Aesthet Dermatol 2016 Nov 1;9(11):44-50. Epub 2016 Nov 1.
    Residency Program Director, New York College of Osteopathic Medicine of New York Institute of Technology, Department of Dermatology, St. Barnabas Hospital, Bronx, New York.
    Lichen planus pigmentosus is a photodistributed dyschromia of unknown etiology described clinically as hyperpigmented gray-blue or brown-black macules or patches in a photodistributed pattern. Although there has been some debate, lichen planus pigmentosus is considered by many to be a separate diagnostic entity from ashy dermatosis or erythema dyschromicum perstans, which shares similar characteristics. Various treatment strategies have been applied to help resolve or improve the appearance of lichen planus pigmentosus lesions; however, an optimal treatment method is yet to be elucidated. Read More

    Polyphenol and Ellagitannin Constituents of Jabuticaba (Myrciaria cauliflora) and Chemical Variability at Different Stages of Fruit Development.
    J Agric Food Chem 2017 Feb 7;65(6):1209-1219. Epub 2017 Feb 7.
    Instituto de Química, Universidade Federal de Goiás , 74690-900, Goiânia, Goiás Brazil.
    A new ellagitannin named cauliflorin (1), seven known hydrolyzable tannins (2-8), and six known phenolics (9-14) were isolated from jabuticaba. Compounds 2-8 had not been previously isolated from M. cauliflora fruits. Read More

    Current Trends in Upper and Lower Eyelid Blepharoplasty Among American Society of Ophthalmic Plastic and Reconstructive Surgery Members.
    Ophthal Plast Reconstr Surg 2017 Feb 1. Epub 2017 Feb 1.
    *Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, †Department of Otolaryngology-Head and Neck Surgery, Division of Facial Plastic and Reconstructive Surgery, Keck School of Medicine, University of Southern California, Los Angeles, ‡David Geffen School of Medicine at the University of California, Los Angeles, §Division of Facial Plastic Surgery, Beverly Hills, ‖Division of Head & Neck Surgery, David Geffen School of Medicine at the University of California, Los Angeles, ¶Center for Advanced Facial Plastic Surgery, Beverly Hills, #Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, and **Division of Ophthalmic Plastic and Reconstructive Surgery, Beverly Hills Ophthalmic Plastic Surgery, Beverly Hills, California, U.S.A.
    Purpose: To assess current practice patterns for management of upper and lower eyelid blepharoplasty by active American Society of Ophthalmic Plastic and Reconstructive Surgery members.

    Methods: An invitation to participate in a web-based anonymous survey was sent to the active American Society of Ophthalmic Plastic and Reconstructive Surgery membership via email. The survey consists of 34 questions, both multiple choice and free response, regarding upper and lower eyelid blepharoplasty surgery. Read More

    Synthesis of Furandicarboxylic Acid Esters From Nonfood Feedstocks Without Concomitant Levulinic Acid Formation.
    ChemSusChem 2017 Apr 1;10(7):1460-1468. Epub 2017 Mar 1.
    Wageningen University Biobased Chemistry and Technology, Bornse Weilanden 9, 6708WG, Wageningen, The Netherlands.
    5-Hydroxymethylfurfural (HMF) is a versatile intermediate in biomass conversion pathways. However, the notoriously unstable nature of HMF imposes challenges to design selective routes to chemicals such as furan-2,5-dicarboxylic acid (FDCA). Here, a new strategy for obtaining furans is presented, bypassing the formation of the unstable HMF. Read More

    Universal Trichloroacetic Acid Peel Technique for Light and Dark Skin.
    JAMA Facial Plast Surg 2017 May;19(3):212-219
    Department of Dermatology, McGill University, Montreal, Quebec, Canada.
    Importance: Despite their great potential, medium and deep trichloroacetic acid peels are underused in light-skinned patients and are rarely used in darker-skinned patients because of the widespread fear of pigmentary complications and scarring. This concern has led many physicians to opt for the use of lighter types of peels (glycolic acid peel, Jessner peel, etc) and different lasers and intense light technologies. Trichloroacetic acid peels have been described in numerous publications. Read More

    Combination Therapy for Acne Scarring: Personal Experience and Clinical Suggestions.
    J Drugs Dermatol 2016 Nov;15(11):1413-1419
    Acne is one of the most prevalent skin conditions seen by dermatologists. The cosmetic sequelae of severe acne, including scarring and pigmentation, have a profound psychological impact on those in icted. Topical (eg, retinoids, antibiotics, dapsone, hydroxyacids) and oral treatments (eg, antibiotics and/or spironolactone) are often bene cial to control acne or in the instance of oral isotretinoin use, rid the acne permanently; however, these treatments have very little affect on the ultimate cosmetic outcome of the acne scarring and skin texture that results. Read More

    Evaluation of different training systems on Annurca apple fruits revealed by agronomical, qualitative and NMR-based metabolomic approaches.
    Food Chem 2017 May 29;222:18-27. Epub 2016 Nov 29.
    Consiglio per la Ricerca in Agricoltura e l'analisi dell'Economia Agraria (CREA), Unità di ricerca per la Frutticoltura, Via Torrino 3, I-81100 Caserta, Italy. Electronic address:
    Nine different training systems for "Annurca Rossa del Sud" apple fruits, including oblique palmette, free palmette, V-shaped, Tatura trellis, Bibaum®, modified Bibaum®, triple leader, slender spindle and Solaxe, were evaluated based on agronomic, qualitative and metabolomic traits. Fruits were analysed at harvest and after the reddening process. The slender spindle training system showed the highest cumulative efficiency yield compared to the others. Read More

    Composition, bioactive compounds and antioxidant activity of common Indian fruits and vegetables.
    J Food Sci Technol 2016 Nov 25;53(11):4056-4066. Epub 2016 Nov 25.
    Department of Food Science and Technology, Guru Nanak Dev University, Amritsar, Punjab 143005 India.
    The present work was undertaken to evaluate the chemical composition (proximate, minerals and dietary fibre), colour parameters, antioxidant activity and polyphenol profiles of different fruits (pomegranate, kinnow, mango, banana, jambolan, grapes and sapodilla) and vegetables (beetroot, brinjal, orange carrot, bitter gourd, mentha and spinach). The amount of insoluble dietary fibre was higher than soluble dietary fibre for all fruits and vegetables. Vegetables showed superior mineral composition (higher amounts of K, Ca and Fe) as compared to fruits. Read More

    Randomized controlled trial comparing 35% trichloroacetic acid peel and 5-aminolaevulinic acid photodynamic therapy for treating multiple actinic keratosis.
    Br J Dermatol 2017 May 5;176(5):1155-1161. Epub 2017 Apr 5.
    Department of Dermatology, Medical University of Vienna, Vienna, SMZ Ost, 122, Langobardenstrasse, 1220, Vienna, Austria.
    Background: Photodynamic therapy (PDT) and chemical peels with trichloroacetic acid (TCA) can be applied to large skin areas and thus are suitable treatment options for patients with multiple actinic keratosis (AK). However, despite its long use, TCA has been investigated only rarely in this indication.

    Objectives: This randomized, observer-blinded, intrapatient comparative study sought to investigate the efficacy and safety of 35% TCA vs. Read More

    Literature Review of Cosmetic Procedures in Men: Approaches and Techniques are Gender Specific.
    Am J Clin Dermatol 2017 Feb;18(1):87-96
    Department of Dermatology, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Ezralow Tower 5301, Los Angeles, CA, 90033, USA.
    The proportion of men receiving non-surgical cosmetic procedures has risen substantially in recent years. Various physiologic, anatomic, and motivational considerations differentiate the treatments for male and female patients. Nevertheless, research regarding approaches to the male cosmetic patient is scarce. Read More

    Study on optimization of process parameters for enhancing the multi-hydrolytic enzyme activity in garbage enzyme produced from preconsumer organic waste.
    Bioresour Technol 2017 Feb 9;226:200-210. Epub 2016 Dec 9.
    Department of Chemical Engineering, National Institute of Technology, Tiruchirappalli, Tamil Nadu 620015, India. Electronic address:
    The garbage enzymes produced from preconsumer organic waste containing multi hydrolytic enzyme activity which helps to solubilize the waste activated sludge. The continuous production of garbage enzyme and its scaling up process need a globe optimized condition. In present study the effect of fruit peel composition and sonication time on enzyme activity were investigated. Read More

    A Limonoid Kihadanin B from Immature Citrus unshiu Peels Suppresses Adipogenesis through Repression of the Akt-FOXO1-PPARγ Axis in Adipocytes.
    J Agric Food Chem 2016 Dec 15;64(51):9607-9615. Epub 2016 Dec 15.
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences , 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
    Citrus limonoids are secondary metabolites and exhibit a variety of biological activities. In this study, we elucidated the suppression of adipogenesis by a Citrus limonoid kihadanin B and determined its molecular mechanism in mouse 3T3-L1 adipocytes. Kihadanin B was purified from the peels of immature Citrus unshiu by HPLC, and its chemical structure was determined by NMR and mass spectrometry. Read More

    Pectinase production by Aspergillus giganteus in solid-state fermentation: optimization, scale-up, biochemical characterization and its application in olive-oil extraction.
    J Ind Microbiol Biotechnol 2017 Feb 22;44(2):197-211. Epub 2016 Nov 22.
    Instituto de Investigaciones Biotecnológicas-Instituto Tecnológico de Chascomús (IIB-INTECH), Universidad Nacional de San Martín (UNSAM)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), San Martín, Buenos Aires, Argentina.
    The application of pectinases in industrial olive-oil processes is restricted by its production cost. Consequently, new fungal strains able to produce higher pectinase titers are required. The aim of this work was to study the capability of Aspergillus giganteus NRRL10 to produce pectinolytic enzymes by SSF and evaluate the application of these in olive-oil extraction. Read More

    Remediation of Cu metal-induced accelerated Fenton reaction by potato peels bio-sorbent.
    Environ Monit Assess 2016 Dec 16;188(12):674. Epub 2016 Nov 16.
    Department of Chemistry, University of Karachi, Karachi, 75270, Pakistan.
    This article has allied exposure to Ecological Particulate Matter (EPM) and its remediation using potato peel surface (PPC) bio-sorbent on two important edible crops Spinacia oleracea and Luffa acutangula. Fenton reaction acceleration was one of the major stress oxidation reactions as a consequence of iron and copper toxicity, which involve in the formation of hydroxyl radical (OH) through EPM. Results showed that the oxidative stress encouraged by Cu in both species that recruits the degradation of photosynthetic pigments, initiating decline in growth, reduced leaf area and degrade proteins. Read More

    Physical, Chemical and Proteomic Evidence of Potato Suberin Degradation by the Plant Pathogenic Bacterium Streptomyces scabiei.
    Microbes Environ 2016 Dec 17;31(4):427-434. Epub 2016 Nov 17.
    Centre SÈVE, Département de Biologie, Université de Sherbrooke.
    Potato peels consist of a tissue called phellem, which is formed by suberized cell layers. The degradation of suberin, a lipidic and recalcitrant polymer, is an ecological process attributed to soil fungal populations; however, previous studies have suggested that Streptomyces scabiei, the causal agent of potato common scab, possesses the ability to degrade suberin. In the present study, S. Read More

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