Organic Solvent as Internal Standards for Quantitative and High-Throughput Liquid Interfacial SERS Analysis in Complex Media.
Anal Chem 2018 Apr 3;90(8):5232-5238. Epub 2018 Apr 3.
College of Food Science and Engineering , Hefei University of Technology , Hefei , Anhui 230009 , China.
Liquid-state interfacial nanoparticle arrays for surface-enhanced Raman scattering (SERS) promises a practical, substrate-free, and rapid analysis but faces a great challenge to develop a batch and uniform fabrication strategy with stable internal standards (IS) because of the difficulties in precisely locating both the IS tags and analytes in the same local structure under the harsh conditions of biphasic liquid interface. Here, we develop a fast batch preparation of self-ordered dense Au nanoparticle (GNP) arrays on cyclohexane/water biphasic interface in 96-well plates with the assist of acetone as the phase-crossing inducer. The acetone can extract the pesticide molecules via a simple dipping sample peels and can rapidly capture and locate the pesticide molecule into the plasmonic hotspots. Read More