199,836 results match your criteria Chemical Engineering Research & Design[Journal]


Spatial-temporal variability of aerosol sources based on chemical composition and particle number size distributions in an urban settlement influenced by metallurgical industry.

Environ Sci Pollut Res Int 2020 Jul 5. Epub 2020 Jul 5.

Department of Public Health Sciences, University of Rochester Medical Center, 265 Crittenden Boulevard, Rochester, NY, 14642-0708, USA.

The Moravian-Silesian region of the Czech Republic with its capital city Ostrava is a European air pollution hot spot for airborne particulate matter (PM). Therefore, the spatiotemporal variability assessment of source contributions to aerosol particles is essential for the successful abatement strategies implementation. Positive Matrix Factorization (PMF) was applied to highly-time resolved PM chemical composition (1 h resolution) and particle number size distribution (PNSD, 14 nm - 10 μm) data measured at the suburban (Ostrava-Plesná) and urban (Ostrava-Radvanice) residential receptor sites in parallel during an intensive winter campaign. Read More

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http://dx.doi.org/10.1007/s11356-020-09694-0DOI Listing

High crosslinked sodium carboxyl methylstarch-g-poly (acrylic acid-co-acrylamide) resin for heavy metal adsorption: its characteristics and mechanisms.

Environ Sci Pollut Res Int 2020 Jul 5. Epub 2020 Jul 5.

College of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu, 610500, People's Republic of China.

A lower expansive heavy metal adsorbent, high crosslinked sodium carboxyl methylstarch-g-poly (acrylic acid-co-acrylamide) resin (HCAA), has been prepared by enhancing the crosslinking degree of the traditional water-absorbing polymer under the graft copolymerization reaction. Further heavy metal adsorption experiments, morphology analysis, and structure characteristic observations indicate that HCAA resin has an excellent heavy metal adsorption properties for Cr, Cu, Ni, and Zn of 80.08, 158. Read More

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http://dx.doi.org/10.1007/s11356-020-09945-0DOI Listing

β-Cyclodextrin coated porous Pd@Au nanostructures with enhanced peroxidase-like activity for colorimetric and paper-based determination of glucose.

Mikrochim Acta 2020 Jul 4;187(8):425. Epub 2020 Jul 4.

Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, Anhui, 230009, People's Republic of China.

β-cyclodextrin-functionalized porous Pd@Au nanostructures (β-CD-Pd@Au) with intrinsic and enhanced peroxidase-like activity were successfully synthesized by a two-step method. The synthesized β-CD-Pd@Au can efficiently catalyze the oxidation of various substrates, such as 3,3',5,5'-tetramethylbenzidine (TMB), mixture of 4-amino antipyrine (4-AAP) and 3,5-dichloro-2-hydroxy acid sodium (DHBS) (4-AAP/DHBS), and mixture of 4-AAP and N-Ethyl-N-(3-sulfopropyl)-3-methyl-aniline sodium salt (TOPS) (4-AAP/TOPS), by HO to generate visual blue, purple, and pink color, respectively. The UV-vis absorbance peak of the three β-CD-Pd@Au catalyzed the chromogenic reaction system located at 650 nm, 510 nm, and 550 nm, respectively. Read More

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http://dx.doi.org/10.1007/s00604-020-04410-8DOI Listing

Effect of ultrasonication on the flotation of fine graphite particles: Nanobubbles or not?

Ultrason Sonochem 2020 Jun 30;69:105243. Epub 2020 Jun 30.

National Engineering Research Center of Coal Preparation and Purification, China University of Mining and Technology, Xuzhou 221116, Jiangsu, China. Electronic address:

It has been reported that nanobubbles can be produced by ultrasonication. However, it remains unclear whether part of the contribution of ultrasonication on flotation performance can be attributed to the generation of nanobubbles. In this work, we systematically studied this point of ultrasonication by combining a series of techniques including flotation testing, AFM (atomic force microscope) measurement, and settling testing. Read More

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http://dx.doi.org/10.1016/j.ultsonch.2020.105243DOI Listing

Recycling application of waste long-root Eichhornia crassipes in the heavy metal removal using oxidized biochar derived as adsorbents.

Bioresour Technol 2020 Jun 27;314:123749. Epub 2020 Jun 27.

National Engineering Research Center for Integrated Utilization of Salt Lake Resources, East China University of Science and Technology, Shanghai 200237, China; State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, East China University of Science and Technology, Shanghai 200237, China.

An oxidized biochar was prepared using long-root Eichhornia crassipes through an aerobic/anaerobic hybrid calcination to recycle its waste plants after eutrophic treatments. The adsorption performances of the biochar were investigated and the results showed that the adsorption equilibrium could arrive in 30 min and the adsorption capacities for Pb, Cu, Cd and Zn at 30 °C were 0.57, 0. Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123749DOI Listing

Field test of electrokinetically-delivered thermally activated persulfate for remediation of chlorinated solvents in clay.

Water Res 2020 Jun 20;183:116061. Epub 2020 Jun 20.

School of Civil and Environmental Engineering, Water Research Centre, University of New South Wales, Sydney, NSW, 2052, Australia. Electronic address:

In situ chemical oxidation (ISCO) has demonstrated success in remediating soil and groundwater contaminated with chlorinated volatile organic compounds (CVOCs). However, its performance is often hindered in low-permeability or heterogeneous media due to an inability to effectively deliver the oxidants. This field-scale study investigated the novel approach of applying electrokinetics (EK) to enhance the delivery of persulfate in a low-permeability media and the ability of electrical resistance heating (ERH) to thermally activate the delivered persulfate. Read More

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http://dx.doi.org/10.1016/j.watres.2020.116061DOI Listing

Multiple strategies for maintaining stable partial nitritation of low-strength ammonia wastewater.

Sci Total Environ 2020 Jun 29;742:140542. Epub 2020 Jun 29.

State Key Joint Laboratory of Environmental Simulation and Pollution Control, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Department of Water Pollution Control, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Stable production of nitrite is an essential technical challenge for mainstream anaerobic ammonia oxidation (Anammox). Due to difficulties in the stable inhibition of nitrite oxidizing bacteria (NOB) and maintenance of long-term partial nitritation (PN), integrated multiple, rather than a single, controlling strategies were preferred especially in a continuous-flow treatment system. A mathematically model was developed to evaluate effects of integrated multiple-strategies on ammonia oxidizing bacteria (AOB) and NOB. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140542DOI Listing

Pyruvate metabolism redirection for biological production of commodity chemicals in aerobic fungus Aspergillus oryzae.

Metab Eng 2020 Jul 2. Epub 2020 Jul 2.

Graduate School of Science, Technology, and Innovation, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe, Hyogo, 657-8501, Japan; Engineering Biology Research Center, Kobe University, 1-1 Rokkodai, Nada, Kobe, 657-8501, Japan; Biomass Engineering Program, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan. Electronic address:

Pyruvate is a central metabolite for the biological production of various chemicals. In eukaryotes, pyruvate produced by glycolysis is used in conversion to ethanol and lactate and in anabolic metabolism in the cytosol, or is transported into the mitochondria for use as a substrate in the tricarboxylic acid (TCA) cycle. In this study, we focused on controlling pyruvate metabolism in aerobic microorganisms for the biological production of various chemicals. Read More

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http://dx.doi.org/10.1016/j.ymben.2020.06.010DOI Listing

Concurrent Antisolvent Electrospraying: A Novel Continuous Crystallization Technique.

J Pharm Sci 2020 Jul 2. Epub 2020 Jul 2.

Centre for Advanced Separations Engineering, Department of Chemical Engineering, University of Bath, Claverton Down, Bath BA2 7AY, UK; Centre for Sustainable and Circular Technologies (CSCT), University of Bath, Claverton Down, Bath BA2 7AY, UK; EPSRC Future Continuous Manufacturing and Advanced Crystallisation Research Hub (CMAC), University of Bath, Claverton Down, Bath BA2 7AY, UK. Electronic address:

Pharmaceutical co-crystals (CCs) are multicomponent materials that enable the development of novel therapeutic products by enhancing the properties of active pharmaceutical ingredients, such as solubility, permeability and bioavailability. Currently, CCs are a commercial reality; nonetheless, their industrial production remains a challenge due to problems related to scale up, control and mode of preparation, which usually relies on batch production rather than continuous. This paper describes the implementation of a concurrent coaxial antisolvent electrospray (Co-E), as a new manufacturing technique, for the synthesis of CCs in a rapid, continuous and controlled manner. Read More

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http://dx.doi.org/10.1016/j.xphs.2020.06.023DOI Listing

Effectiveness of mesenchymal stem cell-seeded onto the 3D polylactic acid/polycaprolactone/hydroxyapatite scaffold on the radius bone defect in rat.

Life Sci 2020 Jul 2:118038. Epub 2020 Jul 2.

Transplant Research Center, Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: The importance of regeneration in large bone defects forces the orthopedic surgeons to search for a proper methodology. The present experiment evaluated the capability of polylactic acid/polycaprolactone/hydroxyapatite (PLA/PCL/HA) scaffold loaded with and without mesenchymal stem cells (MSCs) on bone regeneration.

Methods: Fourier transform infrared spectrometry, X-ray diffraction, scanning electron microscopy, and rheology methodologies were used to characterize the scaffold. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118038DOI Listing

Plasma gasification performances of various raw and torrefied biomass materials using different gasifying agents.

Bioresour Technol 2020 Jun 27;314:123740. Epub 2020 Jun 27.

Department of Chemical Engineering, National Cheng Kung University, Tainan 70101, Taiwan; Department of Chemical and Materials Engineering, Tunghai University, Taichung 407, Taiwan; Research Center for Smart Sustainable Circular Economy, Tunghai University, Taichung 407, Taiwan.

Plasma gasification of raw and torrefied woody, non-woody, and algal biomass using three different gasifying agents (air, steam, and CO) is conducted through a thermodynamic analysis. The impacts of feedstock and reaction atmosphere on various performance indices such as syngas yield, pollutant emissions, plasma energy to syngas production ratio (PSR), and plasma gasification efficiency (PGE) are studied. Results show that CO plasma gasification gives the lowest PSR, thereby leading to the highest PGE among the three reaction atmospheres. Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123740DOI Listing

Volatile fatty acids production from biowaste at mechanical-biological treatment plants: Focusing on fermentation temperature.

Bioresour Technol 2020 Jun 24;314:123729. Epub 2020 Jun 24.

Department of Chemical Engineering and Analytical Chemistry, University of Barcelona, 08028 Barcelona, Spain; Water Research Institute (IdRA), University of Barcelona, 08001 Barcelona, Spain.

The impact of temperature (20, 35, 45, 55, 70 °C) on volatile fatty acid (VFA) production from biowaste collected at a mechanical-biological treatment plant was analysed. Additionally, relevant streams of the treatment plant were characterised to assess seasonality effects and conceive the integration of a fermentation unit. Batch fermentation tests at 35 °C showed the highest VFA yields (0. Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123729DOI Listing

Comparative study of biorefinery processes for the valorization of fast-growing Paulownia wood.

Bioresour Technol 2020 Jun 24;314:123722. Epub 2020 Jun 24.

Center of Biological Engineering, University of Minho. Campus of Gualtar, 4710 057 Braga, Portugal.

In this work, valorization of Paulownia wood (PW) was proposed following several process configurations for biofuels and value-added compounds production. Firstly, autohydrolysis and ethanol-organosolv strategies were assessed separately for the fractionation of PW to enhance the enzymatic digestibility of cellulose. A third strategy focused on a sequential process (autohydrolysis and organosolv) was explored. Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123722DOI Listing

Non-volatile disinfection byproducts are far more toxic to mammalian cells than volatile byproducts.

Water Res 2020 Jun 18;183:116080. Epub 2020 Jun 18.

College of Architecture and Environment, Sichuan University, Chengdu, 610065, PR China.

Water is often chlorinated to protect public health, but chlorination causes harmful disinfection byproducts to form. Currently available in vitro assays generally determine non-volatile disinfection byproduct (NVDBP) toxicities because of the limitation of pretreatments used, but chemical analyses and regulations are focused on volatile disinfection byproducts (VDBPs) such as trihalomethanes. The gap of VDBP toxicities have been of concern for some time. Read More

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http://dx.doi.org/10.1016/j.watres.2020.116080DOI Listing

Formation of algal-derived nitrogenous disinfection by-products during chlorination and chloramination.

Water Res 2020 Jun 16;183:116047. Epub 2020 Jun 16.

AOM Lab, School of Chemical Engineering, The University of New South Wales, Sydney, Australia. Electronic address:

Algal cells and algal organic matter (AOM) are a source of high dissolved organic carbon (DOC) and nitrogen (DON) concentrations. This poses a possible health risk due to their potential to form disinfection by-products (DBPs), some of which may be of health concern, after disinfection. While several studies have focussed on the formation of carbonaceous DBPs from AOM, only a few studies have focussed on the formation of nitrogen containing N-DBPs from AOM. Read More

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http://dx.doi.org/10.1016/j.watres.2020.116047DOI Listing

Silver nanoparticle-base lateral flow immunoassay for rapid detection of Staphylococcal enterotoxin B in milk and honey.

J Inorg Biochem 2020 Jun 24;210:111163. Epub 2020 Jun 24.

Applied Zoology Division, Taiwan Agricultural Research Institute, Taichung 41362, Taiwan.

A silver nanoparticle (AgNP)-based sandwich-type lateral flow immunoassay (LFIA) was evaluated for rapid detection of Staphylococcal enterotoxin B (SEB) in milk and honey. The role of trisodium citrate dihydrate (TSC) in the formation of Ag/TSC nanoparticles was established using UV-Vis spectroscopy. The association of silver with TSC in Ag/TSC nanoparticles was studied by the decrease in the intensity of anodic peak potential at 0. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2020.111163DOI Listing

Heterogeneous electro-Fenton using three-dimension NZVI-BC electrodes for degradation of neonicotinoid wastewater.

Water Res 2020 May 27;182:115975. Epub 2020 May 27.

SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, School of Environment, South China Normal University, Guangzhou, 510006, PR China.

Neonicotinoids (NEOs), as the most widely used pesticides, pose a serious threat to water ecosystems, especially clothianidin (CLO). However, the degradation behavior of CLO, as a new type of persistent organic pollutant, is rarely studied in wastewater treatment. To bridge this gap, heterogeneous electro-Fenton system using three-dimension electrodes made of biochar-supported zero-valent iron nanoparticle hybrid material (NZVI-BC), abbreviated as 3D-ICE-EF system, is invented and initially applied in CLO wastewater degradation, without the addition of Fenton reagent. Read More

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http://dx.doi.org/10.1016/j.watres.2020.115975DOI Listing

Rebar corrosion and its interaction with concrete degradation in reinforced concrete sewers.

Water Res 2020 May 22;182:115961. Epub 2020 May 22.

Advanced Water Management Centre, The University of Queensland, St. Lucia, QLD, 4072, Australia; School of Civil, Mining & Environmental Engineering, The University of Wollongong, Northfields Ave Wollongong, NSW, 2522, Australia. Electronic address:

Concrete corrosion, as a major issue in sewer management, has attracted considerable research. In comparison, the corrosion of reinforcing steel bar (rebar) is not well understood. Particularly, fundamental knowledge of rebar corrosion and its interactions with concrete corrosion/cracking is largely lacking. Read More

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http://dx.doi.org/10.1016/j.watres.2020.115961DOI Listing

Dynamic wetting of solid-liquid-liquid system by molecular kinetic theory.

J Colloid Interface Sci 2020 Jun 27;579:470-478. Epub 2020 Jun 27.

State Key Laboratory of Petroleum Resources and Prospecting, China University of Petroleum (Beijing), Beijing 102249, PR China; Chemical and Petroleum Engineering, University of Calgary, Alberta T2N1N4, Canada.

Hypothesis: The mechanisms of dynamic wetting of solid-liquid-liquid (SLL) system, especially the viscosity effects of two liquids, can be investigated by the molecular kinetic theory (MKT).

Methods: The molecular kinetic theory combined with published data was used to study the roles of a fluid viscosity and a solid surface in dynamic wetting.

Findings: First, the MKT on dynamic wetting was introduced and its limitation was analyzed. Read More

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http://dx.doi.org/10.1016/j.jcis.2020.06.101DOI Listing

Water retention capabilities of collagen, gelatin and peptide as studied by IR/QCM/RH system.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 19;241:118619. Epub 2020 Jun 19.

Department of Earth and Space Science, Osaka University, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, Japan; Faculty of Environmental and Urban Engineering, Kansai University, Yamate-cho 3-3-35, Suita-shi, Osaka 564-8680, Japan; Research Institute for Natural Environment, Science and Technology (RINEST), Tarumi-cho 3-6-32 Maison Esaka 1F, Suita-shi, Osaka 564-0062, Japan. Electronic address:

In this study, water retention properties of triple helix collagen, gelatin (separated single chains) and peptide (broken peptide fragments) were studied by using IR micro-spectroscopy equipped with a relative humidity (RH) control system and quartz crystal microbalance (QCM). Adsorbed water ratios (wt%) are found to be in the order of collagen, gelatin and peptide (at about RH = 60%, 22 wt% for collagen, 14 wt% for gelatin and 9 wt% for peptide). Free water molecules with longer H bonds are the major adsorbed water species for collagen, gelatin and peptide. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118619DOI Listing

Advanced engineered nanoparticulate platforms to address key biological barriers for delivering chemotherapeutic agents to target sites.

Adv Drug Deliv Rev 2020 Jul 1. Epub 2020 Jul 1.

Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA; Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA; McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712, USA; Departments of Pediatrics and Surgery, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA. Electronic address:

The widespread development of nanocarriers to deliver chemotherapeutics to specific tumor sites has been motivated by the lack of selective targeting during chemotherapy inducing serious side effects and low therapeutic efficacy. The utmost challenge in targeted cancer therapies is the ineffective drug delivery system, in which the drug-loaded nanocarriers are hindered by multiple complex biological barriers that compromise the therapeutic efficacy. Despite considerable progress engineering novel nanoplatforms for the delivery of chemotherapeutics, there has been limited success in a clinical setting. Read More

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http://dx.doi.org/10.1016/j.addr.2020.06.030DOI Listing

Lipid nanoparticle technology for therapeutic gene regulation in the liver.

Adv Drug Deliv Rev 2020 Jul 1. Epub 2020 Jul 1.

Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands.

Hereditary genetic disorders, cancer, and infectious diseases of the liver affect millions of people around the globe and are a major public health burden. Most contemporary treatments offer limited relief as they generally aim to alleviate disease symptoms. Targeting the root cause of diseases originating in the liver by regulating malfunctioning genes with nucleic acid-based drugs s holds great promise as a therapeutic approach. Read More

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http://dx.doi.org/10.1016/j.addr.2020.06.026DOI Listing

Current trends in the production of biodegradable bioplastics: The case of polyhydroxyalkanoates.

Biotechnol Adv 2020 Jul 1:107582. Epub 2020 Jul 1.

Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, via Mancinelli 7, 20131 Milano, Italy. Electronic address:

The global pollution caused by plastics and microplastics is stimulating intense research towards more environmentally friendly materials, preserving the remarkable application characteristics of the currently available polymers. Among these, polyhydroxyalkanoates (PHAs) have been hailed as the solution to replace conventional, oil-based plastics. Given their biodegradable nature and mechanical properties, their use can be envisioned in a wide range of applications reducing the environmental footprint. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2020.107582DOI Listing

Energy efficient process for valorization of corn cob as a source for nanocrystalline cellulose and hemicellulose production.

Int J Biol Macromol 2020 Jul 1. Epub 2020 Jul 1.

Department of Chemical Engineering, Alagappa College of Technology, Anna University, Chennai 600025, India. Electronic address:

Synthesis of nanoparticle from biopolymers present in agricultural waste residue is significant as they are eco-friendly and serve as alternative to unrenewable petroleum resources. This research focuses on utilizing Corn cob, a lignocellulosic biomass for the simultaneous production of cellulose and hemicellulose using an energy efficient method. A sequential process of microwave irradiation and ultrasound technique is carried out to obtain cellulose and hemicellulose at a faster rate. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.06.276DOI Listing

Development of Brain Targeting Peptide Based MMP-9 Inhibiting Nanoparticles for the Treatment of Brain Diseases with Elevated MMP-9 Activity.

J Pharm Sci 2020 Jul 1. Epub 2020 Jul 1.

School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, L3 3AF, UK. Electronic address:

Latent and active levels of cerebral matrix metalloproteinase 9 (MMP-9) are elevated in neurological diseases and brain injuries, contributing to neurological damage and poor clinical outcomes. This study aimed developing peptide-based nanoparticles with ability to cross the blood-brain-barrier (BBB) and inhibit MMP-9. Three amphiphilic peptides were synthesised containing brain-targeting ligands (HAIYPRH or CKAPETALC) conjugated with MMP-9 inhibiting peptide (CTTHWGFTLC) linked by glycine (spacer) at the N-terminus, and the peptide sequences were conjugated at the N- terminus to cholesterol. Read More

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http://dx.doi.org/10.1016/j.xphs.2020.06.021DOI Listing

Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury.

Cell 2020 Jul 2. Epub 2020 Jul 2.

Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA; UCLA Cardiovascular Theme, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA; Department of Molecular, Cell and Developmental Biology, College of Letters and Sciences, University of California, Los Angeles, CA 90095, USA; Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA; California Nanosystems Institute, University of California, Los Angeles, CA 90095, USA. Electronic address:

Scar tissue size following myocardial infarction is an independent predictor of cardiovascular outcomes, yet little is known about factors regulating scar size. We demonstrate that collagen V, a minor constituent of heart scars, regulates the size of heart scars after ischemic injury. Depletion of collagen V led to a paradoxical increase in post-infarction scar size with worsening of heart function. Read More

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http://dx.doi.org/10.1016/j.cell.2020.06.030DOI Listing

Enantioselective synthesis of cyclic and linear diamines by imine cycloadditions.

Chirality 2020 Jul 3. Epub 2020 Jul 3.

Biofunctional Synthetic Chemistry Laboratory, RIKEN Cluster for Pioneering Research, Saitama, Japan.

Imine is one of the most versatile functional groups in chemistry and biochemistry fields. Although many biochemical reactions involve imine formation, the inherently unstable property of N-alkyl-α,β-unsaturated imines still hindered their utilization in organic synthesis. In this article, we described that the N-alkyl-α,β-unsaturated imines, which prepared from alkylamines and acrolein, could smoothly react through [4 + 4] cycloaddition to give eight-membered diazacyclooctane derivatives in excellent yields. Read More

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http://dx.doi.org/10.1002/chir.23265DOI Listing

Multifunctional ZnO/SiO Core/Shell Nanoparticles for Bioimaging and Drug Delivery Application.

J Fluoresc 2020 Jul 3. Epub 2020 Jul 3.

Department of Physics and Nanotechnology, SRM Institute of Science and Technology, Chengalpattu District, Tamil Nadu, 603 203, India.

Semiconducting nanoparticles with luminescent properties are used as detection probes and drug carriers in in-vitro and in-vivo analysis. ZnO nanoparticles, due to its biocompatibility and low cost, have shown potential application in bioimaging and drug delivery. Thus, ZnO/SiO core/shell nanoparticle was synthesised by wet chemical method for fluorescent probing and drug delivery application. Read More

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http://dx.doi.org/10.1007/s10895-020-02578-zDOI Listing

Heterophase fcc-2H-fcc gold nanorods.

Nat Commun 2020 Jul 3;11(1):3293. Epub 2020 Jul 3.

Department of Chemistry, City University of Hong Kong, Hong Kong, China.

The crystal phase-based heterostructures of noble metal nanomaterials are of great research interest for various applications, such as plasmonics and catalysis. However, the synthesis of unusual crystal phases of noble metals still remains a great challenge, making the construction of heterophase noble metal nanostructures difficult. Here, we report a one-pot wet-chemical synthesis of well-defined heterophase fcc-2H-fcc gold nanorods (fcc: face-centred cubic; 2H: hexagonal close-packed with stacking sequence of "AB") at mild conditions. Read More

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http://dx.doi.org/10.1038/s41467-020-17068-wDOI Listing

Manipulating interstitial carbon atoms in the nickel octahedral site for highly efficient hydrogenation of alkyne.

Nat Commun 2020 Jul 3;11(1):3324. Epub 2020 Jul 3.

Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, 110016, Shenyang, China.

Light elements in the interstitial site of transition metals have strong influence on heterogeneous catalysis via either expression of surface structures or even direct participation into reaction. Interstitial atoms are generally metastable with a strong environmental dependence, setting up giant challenges in controlling of heterogeneous catalysis. Herein, we show that the desired carbon atoms can be manipulated within nickel (Ni) lattice for improving the selectivity in acetylene hydrogenation reaction. Read More

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http://dx.doi.org/10.1038/s41467-020-17188-3DOI Listing

De novo design of Au(SR) nanoclusters.

Nat Commun 2020 Jul 3;11(1):3349. Epub 2020 Jul 3.

School of Chemistry and Chemical Engineering, Nanjing University, 210093, Nanjing, China.

The discovery of atomically precise nanoclusters is generally unpredictable, and the rational synthesis of nanoclusters guided by the theoretical design is still in its infancy. Here we present a de novo design of Au(SR) nanoclusters, from theoretical prediction to experimental synthesis and characterization of their physicochemical properties. The crystal structure of an Au(SR) nanocluster perfectly matches the simulated structural pattern with Au tetrahedral units along a two-dimensional growth. Read More

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http://dx.doi.org/10.1038/s41467-020-17132-5DOI Listing

Ambient weathering of magnesium oxide for CO removal from air.

Nat Commun 2020 Jul 3;11(1):3299. Epub 2020 Jul 3.

Department of Chemical Engineering, Clean Energy Conversions Lab, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA, 01609, USA.

To avoid dangerous climate change, new technologies must remove billions of tonnes of CO from the atmosphere every year by mid-century. Here we detail a land-based enhanced weathering cycle utilizing magnesite (MgCO) feedstock to repeatedly capture CO from the atmosphere. In this process, MgCO is calcined, producing caustic magnesia (MgO) and high-purity CO. Read More

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http://dx.doi.org/10.1038/s41467-020-16510-3DOI Listing

π covalency in the halogen bond.

Nat Commun 2020 Jul 3;11(1):3310. Epub 2020 Jul 3.

Department of Chemistry, The University of British Columbia, 2036 Main Mall, Vancouver, BC, V6T 1Z1, Canada.

Halogen bonds are a highly directional class of intermolecular interactions widely employed in chemistry and chemical biology. This linear interaction is commonly viewed to be analogous to the hydrogen bond because hydrogen bonding models also intuitively describe the σ-symmetric component of halogen bonding. The possibility of π-covalency in a halogen bond is not contemplated in any known models. Read More

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http://dx.doi.org/10.1038/s41467-020-17122-7DOI Listing

Strain engineering of two-dimensional multilayered heterostructures for beyond-lithium-based rechargeable batteries.

Nat Commun 2020 Jul 3;11(1):3297. Epub 2020 Jul 3.

Centre for Clean Energy Technology, School of Mathematical and Physical Sciences, University of Technology, Sydney, NSW, 2007, Australia.

Beyond-lithium-ion batteries are promising candidates for high-energy-density, low-cost and large-scale energy storage applications. However, the main challenge lies in the development of suitable electrode materials. Here, we demonstrate a new type of zero-strain cathode for reversible intercalation of beyond-Li ions (Na, K, Zn, Al) through interface strain engineering of a 2D multilayered VOPO-graphene heterostructure. Read More

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http://dx.doi.org/10.1038/s41467-020-17014-wDOI Listing

Fine-scale succession patterns and assembly mechanisms of bacterial community of Litopenaeus vannamei larvae across the developmental cycle.

Microbiome 2020 Jul 3;8(1):106. Epub 2020 Jul 3.

State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, 315211, China.

Background: Microbiome assembly in early life may have a long-term impact on host health. Larval nursery is a crucial period that determines the success in culture of Litopenaeus vannamei, the most productive shrimp species in world aquaculture industry. However, the succession patterns and assembly mechanisms of larval shrimp bacterial community still lack characterization at a fine temporal scale. Read More

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http://dx.doi.org/10.1186/s40168-020-00879-wDOI Listing

Effect of different processing methods on physicochemical properties, chemical compositions and in vitro antioxidant activities of Paeonia lactiflora Pall seed oils.

Food Chem 2020 Jun 24;332:127408. Epub 2020 Jun 24.

State Key Laboratory of Food Science and Technology, Jiangnan University, China; National Engineering Research Center for Functional Food, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, China.

A research was performed to determine and compare the physicochemical properties, chemical compositions and in vitro antioxidant activities of Paeonia lactiflora Pall seed oils with ultrasonic-assisted solvent extraction, pressing and supercritical fluid extraction. Paeonia lactiflora Pall seed oil contained a high percentage of polyunsaturated fatty acids and monounsaturated fatty acids, especially oleic (31.62-32. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127408DOI Listing

Methanogenic pathway and microbial succession during start-up and stabilization of thermophilic food waste anaerobic digestion with biochar.

Bioresour Technol 2020 Jun 28;314:123751. Epub 2020 Jun 28.

Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, S117576 Singapore, Singapore; NUS Environment Research Institute, National University of Singapore, 5A Engineering Drive 1, Singapore 117411, Singapore. Electronic address:

One of the major obstacles for thermophilic anaerobic digestion is the process instability during start-up. This study proposed the use of a cost-effective additive, biochar, to accelerate and stabilize the start-up of thermophilic semi-continuous food waste anaerobic digestion. The results showed that the reactors with biochar addition resulted in up to 18% higher methane yield as compared to the control reactors (without biochar). Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123751DOI Listing

Sensitive detection of iron (II) sulfate with a novel reagent using spectrophotometry.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 20;240:118631. Epub 2020 Jun 20.

Istanbul Protein Research Application and Inovation Center (PROMER), Turkey; Department of Molecular Biology and Genetics, Uskudar University, 34662 Uskudar, Istanbul, Turkey. Electronic address:

In this study, a novel reagent was developed for sensitive detection of iron (II) sulfate, spectrophotometrically. A novel thio-anthraquinone derivative, 1-(Dodecylthio)anthracene-9,10-dione (3), was synthesized from the chemical reaction of 1-Chloroanthraquinone (1) and 1-Dodecanethiol (2) by an original reaction method and was used in the preparation of the novel reagent called Catal's reagent. A synthesized thio-anthraquinone analogue (3) was purified by column chromatography, and its chemical structure was characterized by spectroscopic methods such as Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), and ultraviolet (UV)-visible spectrophotometry. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118631DOI Listing

Dual-frequency ultrasound: Strengths and shortcomings to water treatment and disinfection.

Water Res 2020 Jun 8;182:116016. Epub 2020 Jun 8.

Laboratory of Engineering Ecology, Baikal Institute of Nature Management, Siberian Branch of Russian Academy of Sciences, Ulan-Ude, Russia.

Since the early 2000s, dual-frequency ultrasound (DFUS) has received much attention for synergistically enhanced elimination of organic pollutants and pathogenic microorganisms from water. In the present review, we have surveyed recent developments in acoustic physics to elucidate the mechanism of synergistic effect under exposure of aqueous media to DFUS. Briefly, the nonlinear dynamics of microbubbles upon DFUS exposure produces additional frequencies, such as harmonics, subharmonics, ultraharmonics and combination frequencies. Read More

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http://dx.doi.org/10.1016/j.watres.2020.116016DOI Listing

Agrochemicals and obesity.

Mol Cell Endocrinol 2020 Jun 30:110926. Epub 2020 Jun 30.

Department of Developmental and Cell Biology, University of California, Irvine, CA, 92697-2300, USA; Department of Pharmaceutical Sciences, University of California, Irvine, CA, USA; Department of Biomedical Engineering, University of California, Irvine, CA, USA. Electronic address:

Obesity has become a very large concern worldwide, reaching pandemic proportions over the past several decades. Lifestyle factors, such as excess caloric intake and decreased physical activity, together with genetic predispositions, are well-known factors related to obesity. There is accumulating evidence suggesting that exposure to some environmental chemicals during critical windows of development may contribute to the rapid increase in the incidence of obesity. Read More

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http://dx.doi.org/10.1016/j.mce.2020.110926DOI Listing

Phenformin promotes keratinocyte differentiation via the calcineurin/NFAT pathway.

J Invest Dermatol 2020 Jun 30. Epub 2020 Jun 30.

Department of Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China; Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

Phenformin is a drug in the biguanide class that was previously used to treat type 2 diabetes. We have reported the anti-tumor activities of phenformin to enhance the efficacy of BRAF-MEK-ERK pathway inhibition and to inhibit myeloid-derived suppressor cells in various melanoma models. Here we demonstrate that phenformin suppresses tumor growth and promotes keratinocyte differentiation in the DMBA/TPA two stage skin carcinogenesis mouse model. Read More

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http://dx.doi.org/10.1016/j.jid.2020.05.114DOI Listing

What CHO is made of: Variations in the biomass composition of Chinese hamster ovary cell lines.

Metab Eng 2020 Jun 30. Epub 2020 Jun 30.

Acib - Austrian Centre of Industrial Biotechnology, 1190, Vienna, Austria, EU; Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, 1190, Vienna, Austria, EU; Department of Analytical Chemistry, University of Vienna, 1010, Vienna, Austria, EU. Electronic address:

Background: Cell line-specific, genome-scale metabolic models enable rigorous and systematic in silico investigation of cellular metabolism. Such models have recently become available for Chinese hamster ovary (CHO) cells. However, a key ingredient, namely an experimentally validated biomass function that summarizes the cellular composition, was so far missing. Read More

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http://dx.doi.org/10.1016/j.ymben.2020.06.002DOI Listing

Changes in symmetry during gait in adults with Prader-Willi syndrome.

Comput Methods Biomech Biomed Engin 2020 Jul 3:1-8. Epub 2020 Jul 3.

Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy.

Most studies on locomotion of individuals with the Prader-Willi Syndrome (PWS) have been performed in a laboratory setting using quantitative motion analysis. Recently, wireless inertial sensors have been successfully employed for gait analysis in different pathological states with the advantages of reproducing a testing condition very close to those encountered in daily living. Using such devices, it is possible not only to characterize the conventional spatio-temporal parameters, but also extract information on further less conventional metrics, such as the harmonic ratio (HR), a measure of step-to-step symmetry based on trunk acceleration processing. Read More

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http://dx.doi.org/10.1080/10255842.2020.1787999DOI Listing

Release Mechanisms and Applications of Drug Delivery Systems for Extended-Release.

Expert Opin Drug Deliv 2020 Jul 3. Epub 2020 Jul 3.

Department of Industrial and Manufacturing Systems Engineering, Biomedical Engineering Programme, Chemical Biology Centre, and Li Ka Shing Faculty of Medicine, The University of Hong Kong , Pokfulam, HKSAR, China.

Introduction: Drug delivery systems with extended-release profiles are ideal in improving patient compliance with enhanced efficacy. To develop devices capable of a prolonged delivery kinetics, it is crucial to understand the various underlying mechanisms contributing to extended drug release and the impact thereof on modulating the long-term performance of such systems in a practical application environment.

Areas Covered: This review article intends to provide a comprehensive summary of release mechanisms in extended-release drug delivery systems, particularly polymer-based systems; however, other material types will also be mentioned. Read More

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http://dx.doi.org/10.1080/17425247.2020.1788541DOI Listing

Exceptionally Plastic/Elastic Organic Crystals of a Naphthalidenimine-Boron Complex Show Flexible Optical Waveguide Properties.

Chemistry 2020 Jul 3. Epub 2020 Jul 3.

Institute of Nano Science and Technology, Soft Nanostructures Group, Phase 10, Sector 64, 160062, Mohali, INDIA.

Design of molecular compounds exhibiting flexibility is an emerging area of research. Although a fair amount of success has been achieved in the design of plastic or elastic crystals, realizing multi-dimensional plastic and elastic bending remains challenging. We report herein a naphthalidenimine-boron complex that showed size-dependent dual mechanical bending behavior whereas its parent Schiff base was observed to be brittle. Read More

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http://dx.doi.org/10.1002/chem.202002641DOI Listing

Exploitation of the New Reactivity of Vinylcyclopropanes for Palladium-Catalyzed, Asymmetric [5+2] Dipolar Cycloadditions.

Angew Chem Int Ed Engl 2020 Jul 3. Epub 2020 Jul 3.

Central China Normal University, College of Chemistry, CHINA.

Vinylcyclopropanes (VCPs) are commonly used in transition metal-catalyzed cycloadditions, and the exploitation of their recently realized reactivities to construct new cyclic architectures is of great significance in modern synthetic chemistry. Herein, a palladium-catalyzed, visible light-driven, asymmetric [5+2] cycloaddition of VCPs with α-diazoketones was first accomplished by switching the reactivity of the Pd-containing dipolar intermediates from all-carbon 1,3-dipoles to oxo-1,5-dipoles. Enantioenriched 7-membered lactones were produced with good reaction efficiency and selectivity (23 examples, 52-92% yields with up to 99:1 er and 12. Read More

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http://dx.doi.org/10.1002/anie.202006366DOI Listing

Synthesis, Structures, and Properties of Highly Strained Cyclophenylene-Ethynylenes with Axial and Helical Chirality.

Angew Chem Int Ed Engl 2020 Jul 2. Epub 2020 Jul 2.

Tokyo Institute of Technology, Department of Applied Chemistry, Graduate School of Science and Engineering, 2-12-1-S1-9 Ookayama, Meguro-ku, 152-8550, Tokyo, JAPAN.

Single and double cyclophenylene-ethynylenes (CPEs) with axial and helical chirality have been synthesized by the Sonogashira cross-coupling of di- and tetra-ethynyl biphenyls with a U-shaped prearomatic diiodoparaphenylene followed by reductive aromatization. X-ray crystallographic analyses and the DFT calculations revealed that these CPEs possess highly twisted bent structures. Bend angles on the edge of the paraphenylene units were close to the value of [5]cycloparaphenylene (CPP), the smallest CPP to date. Read More

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http://dx.doi.org/10.1002/anie.202006959DOI Listing

Analyzing Plant Cell Wall Ultrastructure by Scanning Near-Field Optical Microscopy (SNOM).

Methods Mol Biol 2020 ;2149:239-249

Department of Civil, Environmental and Geomatic Engineering, Institute for Building Materials (IfB), Zürich, Switzerland.

The importance of lignocellulosic materials in various research areas including for example biorefinery processes and new biomaterials is constantly rising. Therefore, a detailed knowledge on the macromolecular assembly of plant cell walls is needed. However, despite the tremendous progress in the structural and chemical analysis of plant cell walls there are still uncertainties concerning the ultrastructure. Read More

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http://dx.doi.org/10.1007/978-1-0716-0621-6_14DOI Listing
January 2020

Structural characteristics and anti-complement activities of polysaccharides from Sargassum hemiphyllum.

Glycoconj J 2020 Jul 2. Epub 2020 Jul 2.

College of Biotechnology and Bioengineering, Zhejiang University of Technology, 310014, Hangzhou, China.

Three polysaccharides (SH-1, SH-2 and SH-3) were purified from a brown macroalgea, Sargassum hemiphyllum. The autohydrolysis products from each polysaccharide were separated to three fractions (S fractions as oligomers, L fractions as low molecular weight polysaccharides and H fractions as high molecular weight polysaccharides). Mass spectroscopy of S fractions (SH-1-S, SH-2-S and SH-3-S) showed that these three polymers all contained short stretches of sulfated fucose. Read More

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http://dx.doi.org/10.1007/s10719-020-09928-wDOI Listing

Weak-base pretreatment to increase biomethane production from wheat straw.

Environ Sci Pollut Res Int 2020 Jul 2. Epub 2020 Jul 2.

The Gene & Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, WA, 99164, USA.

Weak-base pretreatment of wheat straw was investigated for its ability to improve biomethane production. Anaerobic digestion (AD) was performed on wheat straw pretreated with 3%, 5%, or 7% NaCO as a weak base. Scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier Transform Infrared Spectroscopy (FTIR) spectra demonstrated disruption of lignocellulosic structures by pretreatment. Read More

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http://dx.doi.org/10.1007/s11356-020-09914-7DOI Listing