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Biophysical Regulation of Cell Behavior-Cross Talk between Substrate Stiffness and Nanotopography.

Engineering (Beijing) 2017 Feb 21;3(1):36-54. Epub 2017 Feb 21.

Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.

The stiffness and nanotopographical characteristics of the extracellular matrix (ECM) influence numerous developmental, physiological, and pathological processes . These biophysical cues have therefore been applied to modulate almost all aspects of cell behavior, from cell adhesion and spreading to proliferation and differentiation. Delineation of the biophysical modulation of cell behavior is critical to the rational design of new biomaterials, implants, and medical devices. Read More

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http://dx.doi.org/10.1016/J.ENG.2017.01.014DOI Listing
February 2017
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