Organocatalyst-assisted Ar-(18)F bond formation: a universal procedure for direct aromatic radiofluorination.
Chem Commun (Camb) 2017 Nov 16. Epub 2017 Nov 16.
Realomics Strategic Research Initiative, Department of Chemistry, Faculty for Mathematics and Natural Sciences, University of Oslo, Norway. and Department of Surgery and Neurocience, OUS-Rikshospitalet HF, Oslo, Norway and Norwegian Medical Cyclotron AS, Nydalen, Oslo, Norway.
A metal free, phosphane-catalysed protocol for C-F bond formation based on ipso-elimination of iodanes is described. The reaction proceeds in significantly higher yield and with markedly reduced variability of yields (yield range) than previously described procedures. Rapid and efficient radiofluorination is achieved using unobjectionable chemical reagents with precedence in routine radiotracer production. Read More