45,588 results match your criteria Chemical Communications [Journal]


Fine and bidirectional regulation of toehold-mediated DNA strand displacement by a wedge-like DNA tool.

Chem Commun (Camb) 2020 Jul 3. Epub 2020 Jul 3.

Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. and Department of Obstetrics and Gynaecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

A wedge-like tool was established to finely and bidirectionally regulate the displacement rate of toehold-mediated strand displacement. This novel tool is very robust in terms of sequence generality and is compatible with most of the current DNA nanodevices based on traditional toehold reactions. Read More

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http://dx.doi.org/10.1039/d0cc03722bDOI Listing

Sequence-directed dynamic covalent assembly of base-4-encoded oligomers.

Chem Commun (Camb) 2020 Jul 3. Epub 2020 Jul 3.

Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA and Department of Chemical Engineering, Monash University, Clayton, VIC 3800, Australia. and Department of Materials Science and Engineering, Monash University, Clayton, VIC 3800, Australia.

As an information-bearing biomacromolecule, DNA is encoded in base-4, where each residue site can be occupied by any one of four nucleobases. Mimicking the information dense, sequence-selective hybridization of DNA, we demonstrate two orthogonal dynamic covalent interactions to effect the selective assembly of molecular ladders and grids from base-4-encoded oligo(peptoid)s. Read More

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http://dx.doi.org/10.1039/d0cc01083aDOI Listing

Electric-field-induced supramolecular phase transitions at the liquid/solid interface: cat-assembly from solvent additives.

Chem Commun (Camb) 2020 Jul 3. Epub 2020 Jul 3.

Institute for Advanced Study, Shenzhen University, Shenzhen, Guangdong 518060, China.

We demonstrate by using scanning tunneling microscopy that a series of trace organic solvent additives can efficiently promote the electrically triggered phase transition of trimesic acid (TMA), which would otherwise occur rather sporadically. DFT simulations taking into account the electric field effect elucidate such tailored phase transformations, based on the Gibbs activation and free energies of the deprotonation reactions of TMA. Read More

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http://dx.doi.org/10.1039/d0cc01670eDOI Listing

From plant to probe: semi-synthesis of labelled undecaprenol analogues allows rapid access to probes for antibiotic targets.

Chem Commun (Camb) 2020 Jul 3. Epub 2020 Jul 3.

School of Chemistry and Chemical Engineering, Queen's University Belfast, David Keir Building, Stranmillis Road, Belfast, UKBT9 5AG.

Undecaprenol-containing glycolipids (UCGs) are essential precursors of bacterial glycopolymers and glycoproteins. We report a novel semi-synthetic strategy to prepare labelled UCGs directly from undecaprenol. This one-size-fits-all approach offers a concise and efficient method for obtaining labelled-UCGs, which will allow new mechanistic studies and inhibitor screens to be performed on novel antibiotic targets. Read More

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http://dx.doi.org/10.1039/d0cc03388jDOI Listing

Light-induced molecular rotation triggers on-demand release from liposomes.

Chem Commun (Camb) 2020 Jul 3. Epub 2020 Jul 3.

University of Groningen, University Medical Center Groningen, Department of Biomedical Engineering, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.

Controllable molecular release from delivery vehicles is essential to successfully reduce drug toxicity and improve therapeutic efficacy. Light-powered hydrophobic molecular motors were therefore incorporated in liposomes to use molecular rotation to facilitate on-demand release. The extent of the release was precisely controlled by irradiation times, providing a simple yet sophisticated responsive molecular nanocarrier. Read More

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http://dx.doi.org/10.1039/d0cc02499fDOI Listing

Rhodium(iii)-catalyzed diamidation of olefins via amidorhodation and further amidation.

Chem Commun (Camb) 2020 Jul 3. Epub 2020 Jul 3.

Key Laboratory of Applied Surface and Colloid Chemistry of MOE, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, China.

Rh(iii)-catalyzed synthesis of vicinal diamides has been realized via elaboration of an authenticated Rh-C(sp3) species generated via initial intramolecular amidorhodation of olefins. The second amidation was achieved using both electrophilic and nucleophilic amidating reagents. The reactions proceeded under mild conditions with good yield, broad substrate scope, and excellent functional-group tolerance. Read More

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http://dx.doi.org/10.1039/d0cc00952kDOI Listing

An MRI-visible immunoadjuvant based on hollow GdO nanospheres for cancer immunotherapy.

Chem Commun (Camb) 2020 Jul 3. Epub 2020 Jul 3.

Health and Medical Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan.

Hollow Gd2O3 nanospheres significantly promote the cellular uptake of a tumor antigen by antigen presenting cells, exhibit pH-dependent alteration of the MR signal intensity and markedly enhance the antitumor immunity. Hollow Gd2O3 nanospheres are promising as magnetic resonance imaging (MRI)-visible cancer immunoadjuvants for cancer immunotherapy. Read More

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http://dx.doi.org/10.1039/d0cc03568hDOI Listing

Highly stable 3D porous HMOF with enhanced catalysis and fine color regulation by the combination of d- and p-ions when compared with those of its monometallic MOFs.

Chem Commun (Camb) 2020 Jul 3. Epub 2020 Jul 3.

Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, Shaanxi Key Laboratory of Physico-Inorganic Chemistry, College of Chemistry & Materials Science, Northwest University, Xi'an 710127, P. R. China.

In this study, two new monometallic organic frameworks (MOFs), namely {[Zn1.5L(NMP)(H2O)]·H2O}n (1) and {[Pb2L2(H2O)2]·H2O}n (2), were synthesized for the first time by a new bifunctional N,O-containing 2-(1H-tetrazol-5-yl)terephthalic acid (H2L) ligand. Then, based on the HSAB principle, another porous Pb-Zn heterometallic organic framework (HMOF), namely {[PbZn0. Read More

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http://dx.doi.org/10.1039/d0cc03111aDOI Listing

Molecular layer deposition of hybrid siloxane thin films by ring opening of cyclic trisiloxane (VD) and azasilane.

Chem Commun (Camb) 2020 Jul 3. Epub 2020 Jul 3.

CIC nanoGUNE, 20018 San Sebastian, Spain. and Department of Physics and Centre for Micro- and Nanosciences and Technologies, University of Rijeka, 51000 Rijeka, Croatia and IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain.

In this work, we report the first ring opening vapor to solid polymerization of cyclotrisiloxane and N-methyl-aza-2,2,4-trimethylsilacyclopentane by molecular layer deposition (MLD). This process was studied in situ with a quartz crystal microbalance and the thin film was characterized by X-ray photoelectron spectroscopy, ATR-FTIR and high-resolution transmission electron microscopy. Read More

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http://dx.doi.org/10.1039/d0cc04195eDOI Listing

Novel electrochemiluminescence solid-state pH sensor based on an i-motif forming sequence and rolling circle amplification.

Chem Commun (Camb) 2020 Jul 3. Epub 2020 Jul 3.

Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China and State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Changchun, Jilin 130022, China.

Based on a pH-dependent i-motif forming sequence and rolling circle amplification (RCA) strategy, a novel electrochemiluminescence (ECL) solid-state pH sensor was proposed herein. The sensor showed a wide dynamic response range from pH 4 to 7.4. Read More

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http://dx.doi.org/10.1039/d0cc03694cDOI Listing

In vivo mRNA imaging based on tripartite DNA probe mediated catalyzed hairpin assembly.

Chem Commun (Camb) 2020 Jul 3. Epub 2020 Jul 3.

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China.

Herein, we develop a novel tripartite DNA probe to transport phosphorothioated substrate hairpins and an aptamer for the intramolecular CHA circuit, which achieves detection of a low amount of specific mRNA in living cells and mice. Our study provides an improved strategy to promote in vivo fluorescence imaging applications in early-stage clinical diagnosis. Read More

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http://dx.doi.org/10.1039/d0cc03596cDOI Listing

Oxidised charcoal: an efficient support for NiFe layered double hydroxide to improve electrochemical oxygen evolution.

Chem Commun (Camb) 2020 Jul 3. Epub 2020 Jul 3.

Department of Chemistry, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Ajmer, Rajasthan 305817, India.

We report the facile synthesis of oxidised charcoal supported NiFeLDH (NiFeLDH/OC) at room temperature. It showed unprecedented activity in the oxygen evolution reaction with an overpotential of 240 mV at 10 mA cm-2, which is ∼115 mV less than pure NiFeLDH. The electronic enrichment at the metal sites and enhanced surface area of NiFeLDH/OC are reasons for the improved activity. Read More

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http://dx.doi.org/10.1039/d0cc02880kDOI Listing

Mechanistic insights into polyoxometalate self-assembly in organic solvent: conversion of a cyclic polyoxovanadate-ethoxide to its Lindqvist congener.

Chem Commun (Camb) 2020 Jul 2. Epub 2020 Jul 2.

Department of Chemistry, University of Rochester, Rochester, NY 14627, USA.

We report the synthesis of a cyclic hexavanadate polyoxovanadate-alkoxide cluster, [VO(OC2H5)2]6, and its conversion, under solvothermal conditions, to an oxygen-deficient Lindqvist assembly, [V6O6(OC2H5)12]n (n = 1-, 0). This study presents insights into the mechanism of organo-functionalized polyoxovandate-alkoxide formation, namely identifying essential intermediates and the source of the central μ6-O2- ligand. Read More

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http://dx.doi.org/10.1039/d0cc03464aDOI Listing

(Para)magnetic hybrid nanocomposites for dual MRI detection and treatment of solid tumours.

Chem Commun (Camb) 2020 Jul 2. Epub 2020 Jul 2.

Advanced Magnetic Theranostic Nanostructures Lab, International Iberian Nanotechnology Laboratory, Braga, Portugal.

We report a hybrid magnetic nanocomposite (mHNCs-Dox) incorporating a chemotherapeutic drug and dual superparamagnetic and paramagnetic cargo. This system exhibits dual contrast behaviour in magnetic resonance imaging as well as enhanced therapeutic anti-cancer capabilities as a thermo-enhanced chemotherapy effector. Read More

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http://dx.doi.org/10.1039/d0cc03020aDOI Listing

Tuning the properties of atomically precise gold nanoclusters for biolabeling and drug delivery.

Chem Commun (Camb) 2020 Jul 2. Epub 2020 Jul 2.

Green Catalysis Center and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China.

A structure-determined gold-levonorgestrel nanocluster, Au10(C21H27O2)10 (Au10NC), has been obtained via solvent induced crystal transformation from Au8(C21H27O2)8 (Au8NC), accompanied by a fluorescence color change from green to yellow. A cationic polymer, poly(allylamine hydrochloride) (PAH), was chosen to assemble with Au10NC to prepare monodisperse and stable particles (Au10NC-PAH) with an increased quantum yield of 49.8%. Read More

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http://dx.doi.org/10.1039/d0cc03498cDOI Listing

Phosphorene-quantum-dot-interspersed few-layered MoS hybrids as efficient bifunctional electrocatalysts for hydrogen and oxygen evolution.

Chem Commun (Camb) 2020 Jul 2. Epub 2020 Jul 2.

School of Physics, Indian Institute of Science Education and Research Thiruvananthapuram, Maruthamala PO, Thiruvananthapuram, Kerala 695551, India.

0-D/2-D hybrids made up of phosphorene quantum dot (PQD)-interspersed few-layered MoS2 nanosheets were demonstrated to be efficient electrocatalysts with remarkable bifunctional electrocatalytic activity for oxygen and hydrogen evolution in an alkaline medium. The excellent performance of the PQD/MoS2 hybrids was attributed to their unique morphology, which facilitated charge transfer, leading to improved HER and OER kinetics. Read More

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http://dx.doi.org/10.1039/d0cc03053hDOI Listing

Remarkable self-sorting selectivity in covalently linked homochiral and heterochiral pairs driven by PdL helicate formation.

Chem Commun (Camb) 2020 Jul 2. Epub 2020 Jul 2.

Department of Applied Chemistry, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan. and Department of Chemistry, Graduate School of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.

Imidazole-based ditopic ligands bearing two chiral alkyl groups (LRR, LSS, and LRS) were synthesized. The ligands formed Pd2L4 helicates with palladium ions (Pd2+). Self-sorting occurred between LRR and LRS to form (Pd2+)2(LRR)4 and (Pd2+)2(LRS)4 homoligand assemblies, whereas mixing of LRR and LSS with Pd2+ gave a near statistical mixture. Read More

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http://dx.doi.org/10.1039/d0cc03539dDOI Listing

Construction and immunogenic studies of a mFc fusion receptor binding domain (RBD) of spike protein as a subunit vaccine against SARS-CoV-2 infection.

Chem Commun (Camb) 2020 Jul 2. Epub 2020 Jul 2.

Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.

Herein, we report that a recombinant fusion protein, containing a 457 amino acid SARS-CoV-2 receptor binding domain (RBD, residues 319-541) and a mouse IgG1 Fc domain, could induce highly potent neutralizing antibodies and stimulate humoral and cellular immunity in mice. The antibodies also effectively suppressed SARS-CoV-2 RBD binding to soluble ACE2, indicating that RBD-mFc may be further developed as a safe and effective SARS-CoV-2 vaccine. Read More

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http://dx.doi.org/10.1039/d0cc03263hDOI Listing

Synthesis of di(hetero)aryl sulfides by defluorinative sulfenylation of polyfluoroalkyl ketones with sodium sulfinates or arylsulfonyl chlorides.

Chem Commun (Camb) 2020 Jul 2. Epub 2020 Jul 2.

Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.

A facile incorporation of a privileged sulfide, a naphthofuran framework, and a perfluoroalkyl moiety in one molecule was successfully accomplished through tandem defluorinative sulfenylation of α-perfluoroalkyl ketones with a sulfur source. The reaction presumably proceeds via a sequence involving defluorination, reductive sulfenylation, autoaromatization, and annulation, accompanied by the simultaneous cleavage of four C(sp3)-F bonds and the formation of new C-S and C-O bonds. Read More

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http://dx.doi.org/10.1039/d0cc03303kDOI Listing

Engineering zirconium-based UiO-66 for effective chemical conversion of d-xylose to lactic acid in aqueous condition.

Chem Commun (Camb) 2020 Jul 2. Epub 2020 Jul 2.

School of Energy Science and Engineering, Vidyasirimedhi Institute of Science and Technology, 555 Moo 1 Payupnai, Wangchan, Rayong 21210, Thailand. and Research Network of NANOTEC-VISTEC on Nanotechnology for Energy, Vidyasirimedhi Institute of Science and Technology, Wangchan, Rayong 21210, Thailand.

Utilizing metal-organic frameworks (MOFs) as heterogeneous catalysts is an interesting and important application due to their well-controlled catalytic sites and well-defined porous structures. In this study we apply, for the first time, Zr-based UiO-66 for the catalytic hydrothermal conversion of d-xylose to lactic acid (LA). The reactions are catalyzed by the coordinatively unsaturated Zr4+, as Lewis acid sites, and the hydroxide ion (OH-) located at the defect sites. Read More

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http://dx.doi.org/10.1039/d0cc03424jDOI Listing

Co-Pt bimetallic nanoparticles with tunable magnetic and electrocatalytic properties prepared by atomic layer deposition.

Chem Commun (Camb) 2020 Jul 2. Epub 2020 Jul 2.

National Laboratory of Solid State Microstructures, Materials Science and Engineering Department, College of Engineering and Applied Sciences, Collaborative Innovation Center of Advanced Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing 210093, P. R. China.

Co-Pt bimetallic nanoparticles with adjustable composition and particle size were prepared by the combination of atomic layer deposition and H2 post-deposition annealing. The structure, magnetic and electrocatalytic properties of Co-Pt bimetallic nanoparticles can be facilely tuned by controlling the composition. Read More

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http://dx.doi.org/10.1039/d0cc03381bDOI Listing

Recent advances of dinuclear nickel- and palladium-complexes in homogeneous catalysis.

Chem Commun (Camb) 2020 Jul 2. Epub 2020 Jul 2.

State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China.

The development of dinuclear transition metal catalysis has gained considerable momentum in recent years. The synergistic interaction between two metals enables the development of dinuclear metal catalysts with high efficiency, robustness and uniqueness. In this highlight, we take the transition metals Ni and Pd as examples, and provide a current perspective of synthetic methodology development catalyzed by dinuclear Ni- and Pd-complexes in the past several years. Read More

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http://dx.doi.org/10.1039/d0cc02542aDOI Listing

Chiral stimuli-responsive metallo-supramolecular assembly induced by Cu/Cu redox change.

Chem Commun (Camb) 2020 Jul 2. Epub 2020 Jul 2.

Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg-CNRS UMR7504, 23 rue du Loess, BP 43, 67034 Strasbourg Cedex 2, France.

We investigated the selective formation of homoleptic and heteroleptic metal complexes controlled by means of the chiral molecular instruction of the ligand and the coordination geometry of the metal. Our results showed that chiral self-recognition or self-discrimination may be induced by the CuI/CuII redox transition using cyclic voltammetry. The further use of chiral ditopic ligands led to metallo-supramolecular copolymers with stimuli-responsive controlled arrangement. Read More

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http://dx.doi.org/10.1039/d0cc01716gDOI Listing

Ligand-free ZnS nanoparticles: as easy and green as it gets.

Chem Commun (Camb) 2020 Jul 2. Epub 2020 Jul 2.

Dipartimento di Scienze Chimiche, Università degli Studi di Padova and INSTM UdR, via Marzolo, 1, 35131, Padova, Italy.

The controlled nucleation and crystallization of small pure sphalerite ZnS nanoparticles was achieved under batch and continuous flow conditions at low temperature, in water and without the use of any stabilizing ligand. The obtained nanoparticles displayed a narrow size distribution and high specific surface area. Moreover, the synthesis was suitable to directly obtain stable water-based suspensions and the products were found to be active photocatalysts for the hydrogen evolution reaction. Read More

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http://dx.doi.org/10.1039/d0cc01901aDOI Listing

The wavelength-dependent optical properties of weakly absorbing aqueous aerosol particles.

Chem Commun (Camb) 2020 Jul 2. Epub 2020 Jul 2.

Department of Atmospheric and Oceanic Sciences and Department of Chemistry, McGill University, 805 Sherbrooke Street West, Montreal, QC H3A 0B9, Canada.

The refractive index (RI) is a key quantity in calculating many aerosol properties required for climate models. To accurately describe the RI of aerosol, the wavelength and temperature dependence as well as the variation with aerosol water content must be considered. Aside from water, aged ambient aerosol can contain both inorganic salts and a myriad of organic molecules. Read More

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http://dx.doi.org/10.1039/d0cc02737eDOI Listing

Molecular probe design via the "covalent-assembly" principle.

Chem Commun (Camb) 2020 Jul 2. Epub 2020 Jul 2.

State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.

Fluorescent probes find widespread applications in chemical analysis, biosensing, and disease diagnosis and are also the cornerstones of many cutting-edge biotechnologies. Yet, the numerous probes developed thus far are actually based on a handful of probe design principles. In this article, we wish to summarize the recent progress of the field toward the use of a novel "covalent-assembly" principle for probe design. Read More

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http://dx.doi.org/10.1039/d0cc00542hDOI Listing

Synthesis of tertiary amines by direct Brønsted acid catalyzed reductive amination.

Chem Commun (Camb) 2020 Jul 2. Epub 2020 Jul 2.

School of Chemistry, University of New South Wales, Sydney, Australia.

Tertiary amines are ubiquitous and valuable compounds in synthetic chemistry, with a wide range of applications in organocatalysis, organometallic complexes, biological processes and pharmaceutical chemistry. One of the most frequently used pathways to synthesize tertiary amines is the reductive amination reaction of carbonyl compounds. Despite developments of numerous new reductive amination methods in the past few decades, this reaction generally requires non-atom-economic processes with harsh conditions and toxic transition-metal catalysts. Read More

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http://dx.doi.org/10.1039/d0cc02955fDOI Listing

Organocatalytic asymmetric synthesis of β,β-diaryl ketones via one-pot tandem dehydration/1,6-addition/decarboxylation transformation of β-keto acids and 4-hydroxybenzyl alcohols.

Chem Commun (Camb) 2020 Jul 2. Epub 2020 Jul 2.

Department of Chemistry, Tianjin Key Laboratory of Molecular Optoelectronic Sciences, and Tianjin Collaborative Innovation Centre of Chemical Science & Engineering, Tianjin University, Tianjin 300072, P. R. China. and Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Fuzhou 350207, P. R. China.

Herein we describe an organocatalytic protocol for the asymmetric synthesis of β,β-diaryl ketones. Under the catalysis of a chiral phosphoric acid, 4-hydroxybenzyl alcohols underwent dehydration to form para-quinone methides, which reacted with β-keto acids in 1,6-addition reactions. Upon treatment with Et3N in one-pot, decarboxylation proceeded to provide the desired chiral ketones in nearly quantitative yields with high enantioselectivities. Read More

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http://dx.doi.org/10.1039/d0cc02213fDOI Listing

Precise imaging of mitochondria in cancer cells by real-time monitoring of nitroreductase activity with a targetable and activatable fluorescent probe.

Chem Commun (Camb) 2020 Jul 2. Epub 2020 Jul 2.

Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China.

An activatable and mitochondrial-targetable fluorescent probe was developed. This designed probe showed ratiometric fluorescence and light-up near-infrared emission responsiveness to nitroreductase, achieving precise imaging of mitochondria in cancer cells by real-time monitoring of nitroreductase activity. Read More

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http://dx.doi.org/10.1039/d0cc00494dDOI Listing

Novel copper-based and pH-sensitive nanomedicine for enhanced chemodynamic therapy.

Chem Commun (Camb) 2020 Jul 2. Epub 2020 Jul 2.

State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University & School of Life Sciences, Nanjing University, Nanjing 210093, P. R. China. and Institute of Drug R&D, Nanjing University, Nanjing 210093, P. R. China and Jiangsu Provincial Key Laboratory for Nano Technology, Nanjing University, Nanjing, 210093, P. R. China.

We utilized albumin as a reducing agent to establish novel copper-based and pH-sensitive nanocarrier CuNPs with abundant Cu+, which can encapsulate histone deacetylase (HDAC) inhibitor vorinostat to form uniform and stable nanomedicine V-CuNPs for synergistic chromatin remodelling and chemodynamic therapy. Read More

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http://dx.doi.org/10.1039/d0cc00165aDOI Listing

Right-/left-handed helical G-quartet nanostructures with full-color and energy transfer circularly polarized luminescence.

Chem Commun (Camb) 2020 Jul 1. Epub 2020 Jul 1.

Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Jilin 130022, China.

Right (R)- and left (L)-handed helical G-quartet nanostructures were synthesized for the first time simultaneously via the self-assembly of 5'-guanosine monophosphate (GMP), the helical handedness of which is well regulated by metal ions. These g-nanostructures were further applied as circularly polarized luminescence (CPL) templates to realize full-color R-/L-CPL and Förster resonance energy transfer CPL. The glum value reached 10-2, indicating their excellent template function for CPL materials design and application. Read More

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http://dx.doi.org/10.1039/d0cc02449jDOI Listing

Benzylic C-H heteroarylation of N-(benzyloxy)phthalimides with cyanopyridines enabled by photoredox 1,2-hydrogen atom transfer.

Chem Commun (Camb) 2020 Jul 1. Epub 2020 Jul 1.

State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, China.

A visible light initiated α-C(sp3)-H arylation of N-(benzyloxy)phthalimides with cyanopyridines for the construction of highly valuable pyridinyl-containing diarylmethanols, including bioactive motif-based analogues, is reported. This method enables arylation of the C(sp3)-H bonds adjacent to an oxygen atom through alkoxy radical formation by O-N bond cleavage, 1,2-hydrogen atom transfer (HAT), arylation and C-CN bond cleavage cascades, and offers a means to exploit 1,2-HAT modes to incorporate functional groups for constructing functionalized alcohols. Read More

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http://dx.doi.org/10.1039/d0cc03619fDOI Listing

Emergence of electrical conductivity in a flexible coordination polymer by using chemical reduction.

Chem Commun (Camb) 2020 Jul 1. Epub 2020 Jul 1.

Department of Chemistry, Graduate School of Science, Tohoku University, 6-3 Aza-Aoba, Aramaki, Sendai 980-8578, Japan.

A flexible coordination polymer with a naphthalenediimide core exhibited reversible desorption-adsorption of solvent molecules and an enhancement of electrical conductivity (∼10-7 S cm-1) upon chemical reduction using hydrazine. Read More

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http://dx.doi.org/10.1039/d0cc03062gDOI Listing

Acid-facilitated G-quadruplex/hemin DNAzymes: accompanied by the assembly of quadruplex supramolecules.

Chem Commun (Camb) 2020 Jul 1. Epub 2020 Jul 1.

CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China.

Four types of quadruplex supramolecules containing G-quadruplex (G4)-I-motif interfaces were assembled under slightly acidic conditions, which can interact with hemin to form I-motif-linked G4/hemin DNAzymes. Our data demonstrated that some I-motif-linked DNAzymes are highly acid-dependent due to the stabilization of hemiprotonated cytosine-cytosine (C˙CH+) pairs for the G4 units. Read More

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http://dx.doi.org/10.1039/d0cc03082aDOI Listing

Amphiphilic dendrimers control protein binding and corona formation on liposome nanocarriers.

Chem Commun (Camb) 2020 Jul 1. Epub 2020 Jul 1.

Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.

Amphiphilic polyphenylene dendrimers (PPDs) with distinct lipophilic and positively or negatively charged surface groups were adsorbed onto liposomes and their impact on protein adsorption in blood plasma was studied. The PPD corona reduced binding of specific opsonins and increased the adsorption of proteins controlling cellular uptake based on their surface patches. Read More

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http://dx.doi.org/10.1039/d0cc02486dDOI Listing

Construction of 14-metal lanthanide nanorings with NIR luminescence response to ions.

Chem Commun (Camb) 2020 Jun 30. Epub 2020 Jun 30.

The University of Texas at Austin, Department of Chemistry and Biochemistry, 1 University Station A5300, Austin, Texas 78712, USA.

Two 14-metal lanthanide nanorings [Ln14(HL)2L20(DMF)8(H2O)8] (Ln = Nd(1) and Gd(2)) were constructed from a tridentate ligand. 1 displays NIR luminescence sensing properties towards metal cations and anions, especially Cu2+, Co2+, H2PO4- and F- at a ppm level. Read More

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http://dx.doi.org/10.1039/d0cc04242kDOI Listing

An efficient and facile strategy for trifluoromethylation and perfluoroalkylation of isoquinolines and heteroarenes.

Chem Commun (Camb) 2020 Jun 30. Epub 2020 Jun 30.

Natural Products Research Centre, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.

An effective and regioselective strategy for trifluoromethylation and perfluoroalkylation of isoquinolines and heteroarenes was developed. By combination of TMSCnF2n+1 (n = 1, 2, 3) with PIFA, the method achieved the corresponding perfluoroalkylated products with broad functional group tolerance. Read More

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http://dx.doi.org/10.1039/d0cc00963fDOI Listing

Imines as acceptors and donors in N-heterocyclic carbene (NHC) organocatalysis.

Chem Commun (Camb) 2020 Jun 30. Epub 2020 Jun 30.

Department of Organic Chemistry, Indian Institute of Science, Bangalore-560012, India.

The synthetic potential of imines as electrophiles or as a source of nucleophilic coupling partner in N-heterocyclic carbene (NHC) catalysis for the synthesis of various nitrogen heterocycles and functionalized amines is highlighted in this Feature Article. Electrophilic imines are suitable candidates for intercepting the NHC-derived acyl anions, homoenolate equivalents, and (di)enolates for the synthesis of α-amino ketones and a variety of lactam derivatives. Moreover, enamines generated from imines bearing α-hydrogen could be trapped with α,β-unsaturated acylazoliums for the synthesis of functionalized dihydropyridinones. Read More

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http://dx.doi.org/10.1039/d0cc03290eDOI Listing

Aliphatic polyketones as classic yet new molecular ropes for structural diversity in organic synthesis.

Chem Commun (Camb) 2020 Jun 30. Epub 2020 Jun 30.

Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, Kita 13, Nishi 8 Kita-ku, Sapporo, Hokkaido 060-8628, Japan.

Polyketone compounds play an important role in organic chemistry as a prominent source of reactivity and functionality. Their chemical properties vary widely depending on the ketone sequence in carbon chains. Although vicinal and β-polyketones have been used for more than 150 years, the recent development of new ketone sequences composed of alternating 1,3- and 1,4-diketones has demonstrated the further potential of polyketones as structurally flexible molecular ropes capable of derivatization to π-conjugated chromophores and molecular assemblies. Read More

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http://dx.doi.org/10.1039/d0cc02977gDOI Listing

A fluorous sodium l-prolinate derivative as low molecular weight gelator for perfluorocarbons.

Chem Commun (Camb) 2020 Jun 30. Epub 2020 Jun 30.

Institut des Sciences Moléculaires, CNRS UMR 5255, Univ. Bordeaux, 33405 Talence, France.

We report the first study dealing with the self-assembly of an α-amino acid derivative in perfluorocarbons. Rheology, microscopy, and spectroscopy studies reveal that the fluorous sodium l-prolinate derivative 1 self-assembles in perfluorocarbons to form a three-dimensional network of left-handed nano-helices resulting in solvent gelation. Singlet oxygen lifetime measured in a gel of perfluorodecalin is about 1000 times longer than in pure water. Read More

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http://dx.doi.org/10.1039/d0cc02446eDOI Listing

Trichromatic-emission and dual-ratio semiconducting polymer dots as fluorescent probe for simultaneous quantification of Cu and pH in vitro and in vivo.

Chem Commun (Camb) 2020 Jun 30. Epub 2020 Jun 30.

Laboratory of Functionalized Molecular Solids, Ministry of Education, Anhui Key Laboratory of Chemo/Biosensing, Laboratory of Biosensing and Bioimaging (LOBAB), College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241002, P. R. China.

Novel dual-ratio semiconducting polymer dots (Pdots) with trichromatic-emission in the red, green and blue primary-color regions, are designed as lysosome-targeting nanoprobes for the simultaneous detection and multicolor imaging of pH and Cu2+ in HeLa cells and zebrafish without cross-interference. Read More

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http://dx.doi.org/10.1039/d0cc01811bDOI Listing

Steering alkyne homocoupling with on-surface synthesized metal-organic complexes.

Chem Commun (Camb) 2020 Jun 30. Epub 2020 Jun 30.

Donostia International Physics Center (DIPC), 20018 San Sebastián, Spain. and Centro de Física de Materiales (CFM-MPC), CSIC-UPV/EHU, 20018 San Sebastián, Spain and Ikerbasque, Basque Foundation for Science, 48013 Bilbao, Spain.

We report a multi-step on-surface synthesis strategy. The first step consists in the surface-supported synthesis of metal-organic complexes, which are subsequently used to steer on-surface alkyne coupling reactions. In addition, we analyze and compare the electronic properties of the different coupling motifs obtained. Read More

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http://dx.doi.org/10.1039/d0cc03779fDOI Listing

Intermediate snapshot on the insertion reaction of isocyanates into the Zn-Cp* bond of dizincocene Cp*Zn.

Chem Commun (Camb) 2020 Jun 30. Epub 2020 Jun 30.

Institute of Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CENIDE), University of Duisburg-Essen, 45117 Essen, Germany.

Heteroleptic Zn(i) complexes Cp*Zn-Zn(N(R)C(Cp*)O) (R = Dipp = 2,6-i-Pr2-C6H3 2, t-Bu 3) with unsymmetrically η4-coordinated Cp* substituents represent snapshots of the insertion reaction of RNCO into the Zn-Cp* bond of Cp*2Zn2 1. The bonding situation in 2 and 3, which represent the first Zn(i) olefin complexes, was evaluated by computational calculation and further compared to other Zn(i) complexes. Read More

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http://dx.doi.org/10.1039/d0cc03831hDOI Listing

Enhancement of the oxygen reduction reaction electrocatalytic activity of metallo-corroles using contracted cobalt(iii) CF-corrole incorporated in a high surface area carbon support.

Chem Commun (Camb) 2020 Jun 30. Epub 2020 Jun 30.

Chemistry Department, Bar-Ilan University, Ramat-Gan, Israel.

Molecular oxygen reduction reaction catalysts based on metallo-corrole with the smallest meso-substituent reported to-date, Co(iii)CF3-corrole, was synthesized and compared to the well-studied Co(iii)tpfcorrole when adsorbed on a high surface area carbon support. This study shows the improved electrocatalytic performance with the new corrole, attributed to its unique compact structure, which enables surface interactions in favor of lowering the reaction overpotential by 70 mV. Read More

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http://dx.doi.org/10.1039/d0cc03122dDOI Listing

Monitoring polymer-assisted mechanochemical cocrystallisation through in situ X-ray powder diffraction.

Chem Commun (Camb) 2020 Jun 30. Epub 2020 Jun 30.

Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy.

Time-resolved mechanochemical cocrystallisation studies have so-far focused solely on neat and liquid-assisted grinding. Here, we report the investigation of polymer-assisted grinding reactions using in situ X-ray powder diffraction, revealing that reaction rate is almost double compared to neat grinding and independent of the molecular weight and amount of the polymer additive used. Read More

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http://dx.doi.org/10.1039/d0cc03460fDOI Listing

MLiBePO and MLi(LiP)PO (M = Cs, Rb): deep-ultraviolet nonlinear-optical phosphates with a tetrahedra-substituted paracelsian-like framework.

Chem Commun (Camb) 2020 Jun 29. Epub 2020 Jun 29.

Key Laboratory of Magnetic Molecules and Magnetic Information Material of Ministry of Education, School of Chemistry and Material Science, Shanxi Normal University, Linfen 041004, China.

New paracelsian-like beryllophosphates M4LiBe4P7O24 and their tetrahedra-substituted phases M4Li(Li3P)P7O24 (MLiP2O6, M = Cs, Rb) were designed and synthesized. Interestingly, two types of phases undergo a structural transformation, resulting from the radius and valence charge number of tetrahedral cations. Four crystals demonstrate potential deep-UV NLO properties such as short absorption edges (<190 nm) and phase-matching SHG response. Read More

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http://dx.doi.org/10.1039/d0cc03159cDOI Listing

Manganese-catalysed transfer hydrogenation of esters.

Chem Commun (Camb) 2020 Jun 29. Epub 2020 Jun 29.

School of Chemistry, University of St Andrews, EaStCHEM, St Andrews, Fife, UK.

Manganese catalysed ester reduction using ethanol as a hydrogen transfer agent in place of dihydrogen is reported. High yields can be achieved for a range of substrates using 1 mol% of a Mn(i) catalyst, with an alkoxide promoter. The catalyst is derived from a tridentate P,N,N ligand. Read More

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http://dx.doi.org/10.1039/d0cc02598dDOI Listing

Synthesis and characterization of low-nuclearity lantern-type porous coordination cages.

Chem Commun (Camb) 2020 Jun 26. Epub 2020 Jun 26.

Department of Chemistry & Biochemistry, University of Delaware, Newark, Delaware 19716, USA. and Center for Neutron Science, Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA.

Permanent porosity in lantern-type M4L4 paddlewheel-based cages is rare and has only been reported for naphthalene, naphthyridine, and diethynylbenzene-based linkers. This work presents the design, synthesis, and characterization of small lanterns that exhibit CO2 accessible BET surface areas in excess of 200 m2 g-1. The crystal packing and porosity of these cages can be tuned by either ligand functionalization or the choice of M2+ source used in their synthesis. Read More

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http://dx.doi.org/10.1039/d0cc03266bDOI Listing

A colourimetric high-throughput screening system for directed evolution of prodigiosin ligase PigC.

Chem Commun (Camb) 2020 Jun 26. Epub 2020 Jun 26.

Lehrstuhl für Biotechnologie, RWTH Aachen University, Worringerweg 3, 52074 Aachen, Germany. and DWI-Leibniz Institut für Interaktive Materialien, Forckenbeckstraße 50, 52056 Aachen, Germany.

A colourimetric high-throughput screening system was established for directed evolution of prodigiosin ligase PigC. The two-step system consists of a colony prescreening test and a subsequent photometric 96-well plate assay. Screening PigC epPCR libraries in Pseudomonas putida revealed a PigC variant that achieved a 2. Read More

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http://dx.doi.org/10.1039/d0cc02181dDOI Listing

A near-infrared light-controlled, ultrasensitive one-step photoelectrochemical detection of dual cell apoptosis indicators in living cancer cells.

Chem Commun (Camb) 2020 Jun 26. Epub 2020 Jun 26.

Chongqing Engineering Laboratory of Nanomaterials & Sensor Technologies, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China.

Here, a near-infrared (NIR) light-controlled, ultrasensitive one-step photoelectrochemical (PEC) strategy was constructed to simultaneously detect cell apoptosis indicators, phosphatidylserine (Pho) and sodium-potassium adenosine triphosphatase (Sat), on living cancer cells. Using NIR light as excitation, the signal probe methylene blue (Tagkinetic) could be released, leading to a gradually decreased photocurrent signal Ikinetic; meanwhile, the photocurrent Istable of the signal probe carbon quantum dots (Tagstable) remained stable. The simultaneous detection of Pho and Sat could be achieved based on rapid one-step PEC detection under single NIR light with the assistance of a smart signal decryption strategy with Ikinetic and Istable. Read More

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http://dx.doi.org/10.1039/d0cc02996cDOI Listing