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    Organocatalyst-assisted Ar-(18)F bond formation: a universal procedure for direct aromatic radiofluorination.
    Chem Commun (Camb) 2017 Nov 16. Epub 2017 Nov 16.
    Realomics Strategic Research Initiative, Department of Chemistry, Faculty for Mathematics and Natural Sciences, University of Oslo, Norway. and Department of Surgery and Neurocience, OUS-Rikshospitalet HF, Oslo, Norway and Norwegian Medical Cyclotron AS, Nydalen, Oslo, Norway.
    A metal free, phosphane-catalysed protocol for C-F bond formation based on ipso-elimination of iodanes is described. The reaction proceeds in significantly higher yield and with markedly reduced variability of yields (yield range) than previously described procedures. Rapid and efficient radiofluorination is achieved using unobjectionable chemical reagents with precedence in routine radiotracer production. Read More

    Membrane environment drives cytochrome P450's spin transition and its interaction with cytochrome b5.
    Chem Commun (Camb) 2017 Nov 16. Epub 2017 Nov 16.
    Biophysics and Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA.
    Heme's spin-multiplicity is key in determining the enzymatic function of cytochrome P450 (cytP450). The origin of the low-spin state in ferric P450 is still under debate. Here, we report the first experimental demonstration of P450's membrane interaction altering its spin equilibrium which is accompanied by a stronger affinity for cytochrome b5. Read More

    Controlling the length of self-assembled nanotubes by sonication followed by polymer wrapping.
    Chem Commun (Camb) 2017 Nov 16. Epub 2017 Nov 16.
    Department of Chemistry, The Ohio State University, 100 W. 18th Ave. Columbus, Ohio 43210, USA.
    This work demonstrates that sonication, followed by polymer-wrapping, is an effective strategy to modulate the length of self-assembled nanotubes. The length distributions of the nanotubes were controlled by varying the amplitude of sonication. Wrapping the nanotubes with ionic polymers suspended the propensity of the nanotube fragments to re-assemble over time into their elongated precursors. Read More

    Use of azidonaphthalimide carboxylic acids as fluorescent templates with a built-in photoreactive group and a flexible linker simplifies protein labeling studies: applications in selective tagging of HCAII and penicillin binding proteins.
    Chem Commun (Camb) 2017 Nov 16. Epub 2017 Nov 16.
    Department of Chemistry, Indian Institute of Technology Kharagpur, India.
    This work describes the synthesis of azidonaphthalimide carboxylic acids which act as fluorescent templates with a built-in photoreactive group and a linker thus simplifying the design of protein labeling agents. These were separately connected to selectivity hands like a sulfonamide and ampicillin for successful labeling/detection of HCAII and PBPs, respectively. Read More

    Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite.
    Chem Commun (Camb) 2017 Nov 16. Epub 2017 Nov 16.
    Department of Chemistry, University of Bath, Bath, BA2 7AY, UK.
    Two boronate fluorescent probes have been developed for the detection of peroxynitrite (TCFB1 and TCFB2). TCFB1 was shown to have a low sensitvity towards peroxynitrite and have a poor solubility in aqueous solution whereas TCFB2 demonstrated high sensitivity towards peroxynitrite and mitochondria localisation with the ability to detect exogenous and endogenous peroxynitrite in live cells (Hep-G2, RAW 264.7, HeLa and A459). Read More

    Synthesis and characterization of the first inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD).
    Chem Commun (Camb) 2017 Nov 16. Epub 2017 Nov 16.
    Departments of Anatomy and Neurobiology, Biochemistry and Pharmacology University of California, Irvine, 92697, California, USA.
    N-Acylphosphatidylethanolamine phospholipase D (NAPE-PLD) is a membrane-associated zinc enzyme that catalyzes the hydrolysis of N-acylphosphatidylethanolamines (NAPEs) into fatty acid ethanolamides (FAEs). Here, we describe the identification of the first small-molecule NAPE-PLD inhibitor, the quinazoline sulfonamide derivative 2,4-dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-sulfonamide, ARN19874. Read More

    Reaction monitoring reveals poisoning mechanism of Pd2(dba)3 and guides catalyst selection.
    Chem Commun (Camb) 2017 Nov 16. Epub 2017 Nov 16.
    School of Chemistry, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
    We have discovered that the dba ligand in the commonly used Pd2(dba)3·CHCl3 cross-coupling pre-catalyst is susceptible to bis-arylation when used in the presence of aryl iodides. The in situ formed dbaAr2 ligands result in Pd-species with altered catalytic activity. In the case of study, the room temperature C3 arylation of benzo[b]thiophenes with aryl iodides, we have observed a marked catalyst deactivation when dba is arylated with electron-deficient aryl iodides, accounting for the poor yields obtained in the C3 arylation reactions with these aryl iodides. Read More

    Quantitative chemoproteomic profiling reveals multiple target interactions of spongiolactone derivatives in leukemia cells.
    Chem Commun (Camb) 2017 Nov 16. Epub 2017 Nov 16.
    Center for Integrated Protein Science (CIPSM), Department of Chemistry, Technical University of Munich, Lichtenbergstr. 4, D-85748, Garching, Germany.
    The spongiolactones are marine natural products with an unusual rearranged spongiane skeleton and a fused β-lactone ring. These compounds have potential anticancer properties but their mode of action has yet to be explored. Here we employ activity-based protein profiling to identify the targets of a more potent spongiolactone derivative in live cancer cells, and compare these to the targets of a simpler β-lactone. Read More

    Efficient Ni-catalyzed conversion of phenols protected with 2,4,6-trichloro-1,3,5-triazine (TCT) to olefins.
    Chem Commun (Camb) 2017 Nov 16. Epub 2017 Nov 16.
    Department of Chemistry, Shiraz University, Shiraz 71946684795, Iran.
    An efficient Ni(COD)2/dppf catalyzed olefination of Ar-O-TCT as synthetic equivalents of aryl halides is described. Activation of C-O bonds in phenols as readily available compounds was achieved with 2,4,6-trichloro-1,3,5-triazine (TCT). This method provides practical access to 1,2-disubstituted olefins in high yields and high functional group compatibility. Read More

    Self-assembled [2]catenane in trapezoidal metallacycles with [Cp*Ir]-corners.
    Chem Commun (Camb) 2017 Nov 16. Epub 2017 Nov 16.
    Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, Innovis, #08-03, Singapore 138634, Singapore. and Department of Chemistry, Faculty of Science, National University of Singapore, 3 Science, Drive 3, Singapore, 117543, Singapore and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong.
    A series of trapezoidal metallacycles were synthesized by the selective combination of a rigid with a flexible arm. [2]Catenane 3 was obtained by self-assembly when the cavity size of the trapezoidal rings was optimised. Read More

    Reversing the undesirable pH-profile of doxorubicin via activation of a di-substituted maleamic acid prodrug at tumor acidity.
    Chem Commun (Camb) 2017 Nov 16. Epub 2017 Nov 16.
    Department of Chemistry, State University of New York (SUNY), Binghamton University, P.O. Box 6000, Binghamton, New York 13902, USA.
    The acid-labile behavior of di-substituted maleamic acid (DMA) and its equilibrium with di-substituted maleimide (DMI) are exploited to build an ultra acid-sensitive, small molecule prodrug that can be activated by tumor extracellular pH (pHe) in the range of 6.5-6.9. Read More

    Correction: Synthesis by free radical polymerization and properties of BN-polystyrene and BN-poly(vinylbiphenyl).
    Chem Commun (Camb) 2017 Nov 16. Epub 2017 Nov 16.
    Department of Chemistry, Rutgers University Newark, Newark, NJ 07102, USA.
    Correction for 'Synthesis by free radical polymerization and properties of BN-polystyrene and BN-poly(vinylbiphenyl)' by Wen-Ming Wan et al., Chem. Commun. Read More

    Half-sandwich ruthenium(ii) complexes containing N^N-chelated imino-pyridyl ligands that are selectively toxic to cancer cells.
    Chem Commun (Camb) 2017 Nov 16. Epub 2017 Nov 16.
    Institute of Anticancer Agents Development and Theranostic Application, The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, Department of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China.
    Chemotherapy is limited by its poor selectivity towards cancer cells over normal cells. Herein, we designed half-sandwich ruthenium imino-pyridyl complexes [(η(6)-bz)Ru(N^N)Cl]PF6 to achieve selective cytotoxicity to cancer cells. This kind of ruthenium complex has unique characteristics and is worthy of further exploration in the design of new anticancer drugs. Read More

    Iron-catalyzed peroxidation-carbamoylation of alkenes with hydroperoxides and formamides via formyl C(sp(2))-H functionalization.
    Chem Commun (Camb) 2017 Nov 16. Epub 2017 Nov 16.
    Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211816, China. and Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
    A reaction protocol in which FeCl3 and tert-butyl hydroperoxide facilitated a selective radical coupling reaction of aryl alkenes or 1,3-enynes with tert-butyl hydroperoxide and formamides to prepare an array of β-peroxy amides has been achieved. The β-peroxy amide could serve as a synthetic precursor which was facilely converted to β-hydroxy amide, β-keto amide and β-lactam following subsequent chemical transformation. Read More

    Highlights from Faraday Discussion FDSERS17: Surface Enhanced Raman Scattering - SERS, Glasgow, UK, 30th August-1st September 2017.
    Chem Commun (Camb) 2017 Nov 16. Epub 2017 Nov 16.
    Department of Chemistry, Université de Montréal, H3C 3J7, Canada.
    The 2017 Faraday Discussion on Surface Enhanced Raman Scattering (SERS) attracted more than a hundred delegates from a broad spectrum of backgrounds and experience levels, bringing together leading scientists involved in the long living field of SERS. The meeting gave an overview of the liveliness of the topic, characterised by open questions and fascinating science still to discover. In the following, we discuss the topics covered during this meeting and briefly highlight the content of each presentation. Read More

    Controllable engineering of asymmetric phosphatidylserine-containing lipid vesicles using calcium cations.
    Chem Commun (Camb) 2017 Nov 15. Epub 2017 Nov 15.
    MOE Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China.
    A novel method to produce controllable asymmetric lipid vesicles using Ca(2+) is reported. The enrichment of negatively charged phosphatidylserine (PS) molecules in the inner leaflet is found not due to charge-charge attraction, but rather a modulation effect on the occupying size of the headgroups of PS molecules. Read More

    Exploring the science of thinking independently together: Faraday Discussion Volume 204 - Complex Molecular Surfaces and Interfaces, Sheffield, UK, July 2017.
    Chem Commun (Camb) 2017 Nov 15. Epub 2017 Nov 15.
    Open Innovation Hub for Antimicrobial Surfaces, Surface Science Research Centre, University of Liverpool, L69 3BX, UK.
    The 2017 Faraday Discussion on Complex Molecular Surfaces and Interfaces brought together theoreticians and experimentalists from both physical and chemical backgrounds to discuss the relevant applied and fundamental research topics within the broader field of chemical surface analysis and characterization. Main discussion topics from the meeting included the importance of "disordered" two-dimensional (2D) molecular structures and the utility of kinetically trapped states. An emerging need for new experimental tools to address dynamics and kinetic pathways involved in self-assembled systems, as well as the future prospects and current limitations of in silico studies were also discussed. Read More

    A simple fluorene core-based non-fullerene acceptor for high performance organic solar cells.
    Chem Commun (Camb) 2017 Nov 15. Epub 2017 Nov 15.
    Inorganic and Physical Chemistry Division, CSIR-Indian Institute of Chemical Technology, Uppal road, Tarnaka, Hyderabad-500007, India. and Academy of Scientific and Innovative Research (AcSIR), New Delhi, India.
    A small molecule non-fullerene acceptor based on a fluorene core having a furan π-spacer and end capped with rhodanine (FRd2) is developed for solution processable bulk heterojunction organic solar cells (OSCs). The simplistic synthetic protocol reduces several reaction steps and hence production cost. Extended π-conjugation via furan units and the presence of electronegative rhodanine groups result in a power conversion efficiency of 9. Read More

    Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments.
    Chem Commun (Camb) 2017 Nov 15. Epub 2017 Nov 15.
    Department of Microbiology & Immunology, University of Michigan, Ann Arbor, MI, USA.
    High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal linkage. Nicoyamycin A potently inhibits uropathogenic Escherichia coli growth in low iron medium, a promising step toward developing novel antibiotics to treat recalcitrant bacterial infections. Read More

    Novel fullerene-based porous materials constructed by a solvent knitting strategy.
    Chem Commun (Camb) 2017 Nov 15. Epub 2017 Nov 15.
    School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China. and Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Luoyu Road No. 1037, Wuhan, 430074, China.
    Here we choose a dihydronaphthyl-functionalized C60 fullerene as a building block and utilize a novel solvent knitting strategy based on Friedel-Crafts alkylation reaction to construct two kinds of novel porous materials by using dichloromethane (DCM) and 1,2-dichloroethane (DCE) as solvents and external crosslinkers. The resulting porous materials show relatively high apparent BET surface areas and gas uptake abilities. Read More

    Gram-scale synthesis of monodisperse sulfonated polystyrene nanospheres for rapid and efficient sequestration of heavy metal ions.
    Chem Commun (Camb) 2017 Nov 15. Epub 2017 Nov 15.
    School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China. and College of Environmental and Biological Engineering, Guangdong University of Petrochemical Technology, Maoming, 525000, Guangdong, China.
    Herein, gram-scale monodisperse sulfonated polystyrene (SPS) nanospheres are synthesized and examined as a sorbent for the removal of heavy metal ions (Pb(2+), Zn(2+) and Cu(2+)). The resulting uniform SPS nanospheres exhibit remarkable adsorption capabilities and kinetics, facile regeneration and outstanding recyclability, affording promising applications in food engineering and water cleanup. Read More

    Supramolecular block copolymers for gene delivery: enhancement of transfection efficiency by charge regulation.
    Chem Commun (Camb) 2017 Nov 15. Epub 2017 Nov 15.
    School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
    A class of cationic supramolecular block copolymers with readily controlled charges has been exploited. Upon post-synthetic structural optimization, this copolymer exhibits comparable biocompatibility, greatly improved pDNA condensation capability and biostability, and further enhanced transfection efficiency in vitro. This work provides valuable insight into the creation of advanced nonviral vectors for gene delivery. Read More

    Synthesis and shift-reagent-assisted full NMR assignment of bacterial (Z8,E2,ω)-undecaprenol.
    Chem Commun (Camb) 2017 Nov 15. Epub 2017 Nov 15.
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA.
    The repeating isoprene unit is a fundamental biosynthetic motif. The repetitive structure presents challenges both for synthesis and for structural characterization. In this synthesis of the (Z8,E2,ω)-undecaprenol of prokaryotic glycobiology, we exemplify solutions to these challenges. Read More

    Online monitoring of a photocatalytic reaction by real-time high resolution FlowNMR spectroscopy.
    Chem Commun (Camb) 2017 Nov 15. Epub 2017 Nov 15.
    Centre for Sustainable Chemical Technologies, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
    We demonstrate how FlowNMR spectroscopy can readily be applied to investigate photochemical reactions that require sustained input of light and air to yield mechanistic insight under realistic conditions. The Eosin Y mediated photo-oxidation of N-allylbenzylamine is shown to produce imines as primary reaction products from which undesired aldehydes form after longer reaction times. Facile variation of reaction conditions during the reaction in flow allows for probe experiments that give information about the mode of action of the photocatalyst. Read More

    Gold-catalyzed [2+2+2+2]-annulation of 1,3,5-hexahydro-1,3,5-triazines with alkoxyallenes.
    Chem Commun (Camb) 2017 Nov 15. Epub 2017 Nov 15.
    Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, P. R. China.
    An unprecedented gold-catalyzed [2+2+2+2]-annulation of 1,3,5-hexahydro-1,3,5-triazines with alkoxyallenes has been developed, providing eight-membered heterocycles in good to excellent yields. Deuterium labeling and control experiments reveal the possible reaction mechanism for this annulation. Read More

    Catalytic double hydroarylation of alkynes to 9,9-disubstituted 9,10-dihydroacridine derivatives by an electrophilic phenoxyphosphonium dication.
    Chem Commun (Camb) 2017 Nov 15. Epub 2017 Nov 15.
    Department of Chemistry, University of Toronto, Toronto, 80 St. George St., Ontario M5S 3H6, Canada.
    The electrophilic pyridinium-substituted phenoxy-phosphonium dicationic salt [(PhO)P(2-(N-Mepy))Ph2][B(C6F5)4]2, is shown to be an effective catalyst for the double hydroarylation of alkynes with diarylamines to afford a series of 9-methyl-9-aryl-9,10-dihydroacridine and 9,10-dimethyl-9-aryl-9,10-dihydroacridine derivatives. Read More

    Visible-light-induced installation of oxyfluoroalkyl groups.
    Chem Commun (Camb) 2017 Nov 15. Epub 2017 Nov 15.
    Department of Chemistry, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea.
    (Hetero)aryloxytetrafluoroethylation of heteroaromatics and alkenes has been achieved by visible-light photocatalysis utilizing readily synthesized oxyfluoroalkyl reagents. The mild reaction conditions and the high diversity on both substrates and oxyfluoroalkyl reagents make this a useful method for late-stage modifications in the development of various functional molecules. Read More

    Surface-enhanced Raman spectroscopy: bottlenecks and future directions.
    Chem Commun (Camb) 2017 Nov 15. Epub 2017 Nov 15.
    State Key Laboratory of Physical Chemistry of Solid Surfaces, iChEM, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
    In this feature article, we discuss in detail developmental bottleneck issues in Raman spectroscopy in its early stages and surface-enhanced Raman spectroscopy (SERS) in the past four decades. We divide SERS research into two different directions with different targets. Fundamental research is extending the limits of SERS to single-molecule, sub-nanometer resolution and femtosecond processes. Read More

    Light-promoted metal-free cross dehydrogenative couplings on ethers mediated by NFSI: reactivity and mechanistic studies.
    Chem Commun (Camb) 2017 Nov 15. Epub 2017 Nov 15.
    Institut des Sciences Moléculaires, CNRS UMR 5255, Univ. Bordeaux, Talence 33405, France.
    Cross dehydrogenative couplings on ethers occur very effectively using N-fluorobis(phenyl)sulfonimide (NFSI) as oxidizing agent under UVA irradiation in the presence of 2 mol% benzophenone. The reaction was shown to proceed first by fast radical fluorination of the α-C-H bond of ethers, followed by HF elimination to yield the highly electrophilic oxocarbenium ion as a key intermediate. Read More

    Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase.
    Chem Commun (Camb) 2017 Nov 14. Epub 2017 Nov 14.
    Department of Chemistry & Konstanz Research School Chemical Biology, University of Konstanz, Universitätsstr. 10, D-78457 Konstanz, Germany.
    The possibility to sequence cytotoxic O(6)-alkylG DNA adducts would greatly benefit research. Recently we reported a benzimidazole-derived nucleotide that is selectively incorporated opposite the damaged site by a mutated DNA polymerase. Here we provide the structural basis for this reaction which may spur future developments in DNA damage sequencing. Read More

    Exploration of VPO4 as a new anode material for sodium-ion batteries.
    Chem Commun (Camb) 2017 Nov 14. Epub 2017 Nov 14.
    Guangzhou Key Laboratory for Surface Chemistry of Energy Materials, New Energy Research Institute, School of Environment and Energy, South China University of Technology, Guangzhou 510006, P. R. China.
    Carbon-coated VPO4 nanoparticles embedded into a porous carbon matrix were synthesized via a facile sol-gel approach and investigated as a novel polyanion anode material for sodium-ion batteries. The VPO4@carbon anode demonstrates excellent rate capability and superior cyclic stability (245.3 mA h g(-1) at 1000 mA g(-1) after 200 cycles). Read More

    Prebiotic RNA polymerisation: energetics of nucleotide adsorption and polymerisation on clay mineral surfaces.
    Chem Commun (Camb) 2017 Nov 14. Epub 2017 Nov 14.
    Nano-Science Center, Department of Chemistry, University of Copenhagen, Universitetsparken 5, Copenhagen OE 2100, Denmark. and Physical Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA and Geography & Earth Sciences, Aberystwyth University, UK.
    We measured the binding energy and bonding parameters between model nucleotide functional groups and model clay mineral surfaces in solutions of acidic pH. We demonstrate that basal surfaces of clay minerals interact most strongly with nucleobases and show that the adsorption of the phosphate group to clay edges could facilitate polymerisation. Our results suggest that Al- and Fe-rich edge sites behave similarly in nucleotide polymerisation through change of the phosphodiester bond strength. Read More

    In situ TEM studies of the shape evolution of Pd nanocrystals under oxygen and hydrogen environments at atmospheric pressure.
    Chem Commun (Camb) 2017 Nov 14. Epub 2017 Nov 14.
    Center of Electron Microscopy and State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China.
    We demonstrate an atomic scale TEM observation of shape evolutions of Pd nanocrystals under oxygen and hydrogen environments at atmospheric pressure. Combined with multi-scale structure reconstruction model calculations, the reshaping mechanism is fully understood. Read More

    Water-soluble Au nanoclusters for multiplexed mass spectrometry imaging.
    Chem Commun (Camb) 2017 Nov 14. Epub 2017 Nov 14.
    CAS Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Dalian 116023, China.
    Homogeneous and water-soluble Au nanoclusters with high UV photon adsorption and high biocompatibility were utilized to enhance the detection sensitivity and lateral resolution of multiplexed mass spectrometry imaging based on laser desorption/ionization. Read More

    An acyclic zincagermylene: rapid activation of dihydrogen at sub-ambient temperature.
    Chem Commun (Camb) 2017 Nov 14. Epub 2017 Nov 14.
    School of Chemistry, Monash University, PO Box 23, VIC, 3800, Australia.
    The first example of a stable zincagermylene, :Ge(TBoN)(ZnL*) (TBoN = N(SiMe3){B(DipNCH)2}, Dip = C6H3Pr(i)2-2,6; L* = -N{C6H2[C(H)Ph2]2Me-2,6,4}(SiPr(i)3)) is prepared and shown to have unprecedented reactivity for a germylene, with respect to the activation of dihydrogen. Computational analyses point towards this being partially derived from the electron releasing nature of the amido-zinc fragment, which leads to a narrowing of the HOMO-LUMO gap in the compound. Read More

    Aggregation-induced emission assembled ultrathin films for white light-emitting diodes.
    Chem Commun (Camb) 2017 Nov 14. Epub 2017 Nov 14.
    State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
    Avoiding the intractable aggregation-caused quenching in solid-state materials, two aggregation-induced emission molecules were first implemented to fabricate white-light emitting ultrathin films with boosted quantum yields via layer-by-layer assembly. Such an ultrathin film-coated white light-emitting diode exhibits color purity. Read More

    Tunable plasmon resonance of molybdenum oxide nanoparticles synthesized in non-aqueous media.
    Chem Commun (Camb) 2017 Nov 14. Epub 2017 Nov 14.
    Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan.
    Plasmonic compound nanoparticles (NPs) have attracted great interest because they are prepared at lower cost and show unique optical properties. However, full replacement of the plasmonic noble metal NPs with the compound NPs has been difficult because most of the compound NPs exhibit plasmon resonance in the infrared range owing to low free carrier density and mobility. In order to overcome this limitation, we developed a new synthetic method for plasmonic MoO2 and MoO3-x NPs. Read More

    Azulene-boronate esters: colorimetric indicators for fluoride in drinking water.
    Chem Commun (Camb) 2017 Nov 14. Epub 2017 Nov 14.
    Centre for Sustainable Chemical Technologies, University of Bath, Bath, BA2 7AY, UK. and Department of Chemistry, University of Bath, Bath, BA2 7AY, UK.
    Low cost and in situ fluoride detection by non-experts is important for the determination of drinking water safety in developing countries. Colour reagents can provide results quickly without expensive equipment, but colorimetric fluoride indicators are often nonspecific, complex to use or do not work in water. Here we show that azulene-boronate indicators respond selectively to fluoride at concentrations relevant to the WHO limit of 1. Read More

    Organocatalysis using aldehydes: the development and improvement of catalytic hydroaminations, hydrations and hydrolyses.
    Chem Commun (Camb) 2017 Nov 13. Epub 2017 Nov 13.
    Centre for Catalysis Research and Innovation, Department of Chemistry and Biomolecular Sciences, University of Ottawa, 10 Marie-Curie, Ottawa, ON K1N, 6N5, Canada.
    Organocatalysis has emerged as a powerful approach to facilitate and accelerate various difficult reactions. This Feature article presents recent developments and improvements using aldehydes as catalysts in difficult Cope-type intermolecular hydroamination, hydration and hydrolysis reactions. Most reactions exploit temporary intramolecularity. Read More

    G-Quartet hydrogels for effective cell growth applications.
    Chem Commun (Camb) 2017 Nov 13. Epub 2017 Nov 13.
    "Petru Poni" Institute of Macromolecular Chemistry, Centre Advanced Research in Bionanoconjugates and Biopolymers, 41A, Gr. Ghica Voda, 700487 Iasi, Romania and Institut Europeen Membranes, Adaptive Supramolecular Nanosystems Group, Université de Montpellier, ENSCM, CNRS, Pl Eugene Bataillon, CC47, F-34095 Montpellier 5, France.
    Functional G-quartet hydrogels formed from natural guanosine cross linked with benzene-1,4-diboronic acid and Mg(2+) support cell growth with no visible signs of gel degradation. Read More

    Imaging cellular trafficking processes in real time using lysosome targeted up-conversion nanoparticles.
    Chem Commun (Camb) 2017 Nov 13. Epub 2017 Nov 13.
    CSIR-Central Salt & Marine Chemicals Research Institute, Bhavnagar 364002, Gujarat, India.
    β-NaYF4:Yb,Gd up-conversion nanoparticles, UCNPs, surface functionalized with suitable targetting peptides function as nontoxic lysosome-specific imaging probes. Read More

    A continuous luminescence assay for monitoring kinase activity: signalling the ADP/ATP ratio using a discrete europium complex.
    Chem Commun (Camb) 2017 Nov 13. Epub 2017 Nov 13.
    Department of Chemistry, Loughborough University, Epinal Way, Loughborough, LE11 3TU, UK.
    We report the application of a stable cationic europium complex [Eu.1]+ in a continuous-read luminescence assay for kinase activity. [Eu. Read More

    Catalytic CO oxidation over Pd70Au30(111) alloy surfaces: spectroscopic evidence for Pd ensemble dependent activity.
    Chem Commun (Camb) 2017 Nov 13. Epub 2017 Nov 13.
    Department of Chemistry, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
    Catalytic CO oxidation over Pd(111) and Pd70Au30(111) surfaces was investigated by in situ spectroscopic observations to understand the alloying effect. The reaction behaviour on Pd70Au30(111) is greatly different from that on Pd(111). Pd monomer and dimer ensembles can act as active centers, whereas triangular-shaped trimers and larger ensembles are inactive. Read More

    Metallic Fe nanoparticles trapped in self-adapting nanoreactors: a novel high-capacity anode for aqueous Ni-Fe batteries.
    Chem Commun (Camb) 2017 Nov 13. Epub 2017 Nov 13.
    Institute for Clean Energy and Advanced Materials, Faculty of Materials and Energy, Southwest University, Chongqing, 400715, P. R. China.
    Metallic Fe nanoparticles trapped in thick carbon nanoreactors are realized in situ via conventional gas-phase reactions. These derived nanohybrids exhibit unique self-adapting properties, with prominent anodic performance in terms of both stored capacity and cyclic durability when serving as anodes for Ni-Fe batteries. Read More

    Solution-processed single crystal microsheets of a novel dimeric phthalocyanine-involved triple-decker for high-performance ambipolar organic field effect transistors.
    Chem Commun (Camb) 2017 Nov 13. Epub 2017 Nov 13.
    Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline Materials, Department of Chemistry, University of Science and Technology Beijing, Beijing 100083, P. R. China. and School of Science, China University of Petroleum (East China), Qingdao 266580, P. R. China.
    Well-defined single crystal microsheets of a novel dimeric phthalocyanine involved sandwich-type triple-decker complex [Pc(SC6H13)8]2Eu2[BiPc(SC6H13)12]Eu2[Pc(SC6H13)8]2 (1) are successfully prepared via a facile solution process. High-performance single crystal OFETs with a hole mobility of 18 cm(2) V(-1) s(-1) and an electron mobility of 0.3 cm(2) V(-1) s(-1) are obtained. Read More

    Evidence for heterolytic cleavage of a cyclic oxonium ylide: implications for the mechanism of the Stevens [1,2]-shift.
    Chem Commun (Camb) 2017 Nov 10. Epub 2017 Nov 10.
    Department of Chemistry, University of Alberta, E3-43 Gunning-Lemieux Chemistry Centre, Edmonton, Alberta T6G 2G2, Canada.
    Formation and rearrangement of several oxonium ylides containing cyclopropylcarbinyl migrating groups were studied. Efficient ring-contraction by [1,2]-shift to form cyclopropane-substituted cyclobutanones was observed, with no competing cyclopropane fragmentation. Substitution with the hypersensitive mechanistic probe (trans,trans-2-methoxy-3-phenylcyclopropyl)methyl led to cyclopropane fragmentation via an apparent heterolytic pathway, providing the first evidence for ion pair intermediates from ylide cleavage, and suggesting a possible alternative heterolytic mechanism for the Stevens [1,2]-shift. Read More

    3D organic Na4C6O6/graphene architecture for fast sodium storage with ultralong cycle life.
    Chem Commun (Camb) 2017 Nov 10. Epub 2017 Nov 10.
    Key Laboratory of Aerospace Advanced Materials and Performance of Ministry of Education, School of Materials Science & Engineering, Beihang University, Beijing, 100191, China.
    Sodium-ion batteries (SIBs) have aroused increasing interest as one of the most promising replacements for lithium-ion batteries (LIBs). Here, a novel organic-inorganic 3D Na4C6O6-graphene architecture was successfully fabricated from commercial Na2C6O6 and for the first time applied for sodium storage. Hence, the 3D Na4C6O6-graphene architecture exhibits a high reversible capacity, good cyclic performance and high-rate capability for sodium storage. Read More

    A naphthalimide-based solid state luminescent probe for ratiometric detection of aluminum ions: in vitro and in vivo applications.
    Chem Commun (Camb) 2017 Nov 10. Epub 2017 Nov 10.
    Department of Chemistry, UGC Sponsored Centre for Advanced Studies-II, Guru Nanak Dev University, Amritsar, Punjab, India.
    A naphthalimide-based fluorescent probe 4 has been designed and synthesized that detects Al(3+) ions in solution, solid state and in biological systems, including cells, tissues and nematodes. Further, a portable kit has been developed using probe 4 for the on-site detection of Al(3+) ions. Read More

    Recent developments in transition-metal photoredox-catalysed reactions of carbonyl derivatives.
    Chem Commun (Camb) 2017 Nov 10. Epub 2017 Nov 10.
    Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, USA. and Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, New York 11794-3400, USA.
    Single-electron reduction of C[double bond, length as m-dash]O and C[double bond, length as m-dash]N bonds of aldehydes, ketones, and imines results in the formation of ketyl and α-aminoalkyl anion radicals, respectively. These reactive intermediates are characterized by an altered electronic character with respect to their parent molecules and undergo a diverse range of synthetically useful transformations, which are not available to even-electron species. This Review summarizes the reactions of ketyl and α-aminyl radicals generated from carbonyl derivatives under transition-metal photoredox-catalysed conditions. Read More

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