1,511,536 results match your criteria Chemical And Process Engineering-inzynieria Chemiczna I Procesowa[Journal]


A Systematic Review on Secondary Metabolites of Paecilomyces Species: Chemical Diversity and Biological Activity.

Planta Med 2020 Jul 9. Epub 2020 Jul 9.

Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao, People's Republic of China.

Fungi are well known for their ability to synthesize secondary metabolites, which have proven to be a rich resource for exploring lead compounds with medicinal and/or agricultural importance. The genera , and are the most widely studied fungal groups, from which a plethora of bioactive metabolites have been characterized. However, relatively little attention has been paid to the genus , which has been reported to possess great potential for its application as a biocontrol agent. Read More

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http://dx.doi.org/10.1055/a-1196-1906DOI Listing

Liquid Fungal Cocultivation as a Strategy to Access Bioactive Metabolites.

Planta Med 2020 Jul 9. Epub 2020 Jul 9.

Department of Chemistry, Federal University of São Carlos (UFSCar), São Carlos, SP, Brazil.

Fungi are a rich source of bioactive compounds. Fungal cocultivation is a method of potentiating chemical interactions and, consequently, increasing bioactive molecule production. In this study, we evaluated the bactericidal, antiprotozoal, and cathepsin V inhibition activities of extracts from axenic cultures of 6 fungi (, and ) that infest tropical fruits and 57 extracts obtained by their cocultivation. Read More

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http://dx.doi.org/10.1055/a-1200-2046DOI Listing

Airbag Burns: An Unfortunate Consequence of Motor Vehicle Safety.

J Burn Care Res 2020 Jul 10. Epub 2020 Jul 10.

University of Rochester Medical Center, Department of Surgery, Division of Plastic Surgery.

Thousands of people are injured in motor vehicle collisions daily and mandated installation of airbags protect passengers but can also cause injuries from deployment including cutaneous burns. We sought to characterize the patterns and outcomes of burns resulting from airbag deployment by performing a retrospective review of all patients evaluated by the burn service from 5/1/2015-4/30/2019. Inclusion criteria was patients of all ages with burn injuries related to airbag deployment. Read More

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http://dx.doi.org/10.1093/jbcr/iraa117DOI Listing

Effect of ultrasound on leaching of lead from landfilled metallurgical residues.

Ultrason Sonochem 2020 Jul 2;69:105239. Epub 2020 Jul 2.

Process Engineering for Sustainable Systems (ProcESS), Department of Chemical Engineering, KU Leuven, Leuven, Belgium. Electronic address:

The potential of ultrasound as a process intensification technique in the extraction of lead from a landfilled metallurgical residues is explored. The silent or non-sonicated process makes use of acidic sodium chloride as the leachate with lead leaching in the range of 45% if a three-stage process is followed. The mixture was sonicated in a batch setup manufactured in-house. Read More

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http://dx.doi.org/10.1016/j.ultsonch.2020.105239DOI Listing

Quantitative X-ray fluorescence analysis: Trace level detection of toxic elemental impurities in drug product by ED-XRF spectrometer.

J Pharm Biomed Anal 2020 Jun 23;189:113292. Epub 2020 Jun 23.

Amneal Pharmaceuticals Pvt. Ltd., Ahmedabad, 382213, India.

Inorganic impurity analysis of pharmaceutical drug products is of paramount importance at trace levels due to the availability of toxic metals. The existing techniques require extensive development and chemical treatment to evaluate the presence of class I (Pb, Cd, Hg and As) and class II (Co, V and Ni) heavy metal elements which are harmful to the environment. To overcome these issues, a cost and time effective wavelength dispersive X-ray fluorescence spectrometry (XRF) was introduced to determine the concentration of trace elements in one of the angiotensin receptor blocker (ARB) (tablet sample 300 mg) according to guidelines addressed in ICH Q3D and USP. Read More

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http://dx.doi.org/10.1016/j.jpba.2020.113292DOI Listing

Green synthesis and environmental application of iron-based nanomaterials and nanocomposite: A review.

Chemosphere 2020 Jun 28;259:127509. Epub 2020 Jun 28.

Department of Chemical Engineering, Indian Institute of Technology Guwahati, Guwahati, 781039, India. Electronic address:

Green chemistry has been proven to be an efficient route for nanoparticle synthesis. Plant extract based green synthesis of various nanoparticles is extensively studied since the last decade. This paper "Green synthesis and environmental application of Iron-based nanomaterials and nanocomposite: A review" unveils all the possible greener techniques for the synthesis of iron-based nanoparticles and nanocomposites. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127509DOI Listing

Adsorption and catalytic oxidation of arsenite on Fe-Mn nodules in the presence of oxygen.

Chemosphere 2020 Jun 30;259:127503. Epub 2020 Jun 30.

Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of Yangtse River), Ministry of Agriculture and Rural Affairs of the People's Republic of China, Hubei Key Laboratory of Soil Environment and Pollution Remediation, College of Resources and Environment, Huazhong Agricultural University, Wuhan, 430070, Hubei Province, China. Electronic address:

Fe-Mn nodules affect the speciation, transformation and migration of arsenic (As) via redox and adsorption reactions. However, few studies have been concerned with their interaction in the presence of dissolved oxygen. In this work, the interaction mechanism of As(III) and Fe-Mn nodules was studied in different atmospheres. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127503DOI Listing

Enhancing membrane surface antifouling by implanting amphiphilic polymer brushes using a swelling induced entrapment technique.

Colloids Surf B Biointerfaces 2020 Jun 24;195:111212. Epub 2020 Jun 24.

Research Center for Membrane and Film Technology, Department of Chemical Science and Engineering, Kobe University, 1-1 Rokkodai, Nada, Kobe, 657-8501, Japan.

In this work, a swelling induced entrapment technique was developed to enhance the hydrophilicity and antifouling performances of polypropylene (PP) microfiltration membranes. By this method, three amphiphilic polymers with different chemical structures (i.e. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.111212DOI Listing

Catalytic ozonation of bio-treated coking wastewater in continuous pilot- and full-scale system: Efficiency, catalyst deactivation and in-situ regeneration.

Water Res 2020 Jun 29;183:116090. Epub 2020 Jun 29.

School of Chemical and Environmental Engineering, China University of Mining and Technology (Beijing), Beijing, 100083, PR China.

In this study, the performance of catalytic ozonation in the treatment of bio-treated coking wastewater (BCW) using pilot- and full-scale systems was investigated. Additionally, the removal efficiency of organic pollutants from BCW, the deactivation mechanism of MnCeO/γ-AlO, and backflushing optimization for in-situ catalyst regeneration, which have not been previously investigated, were analysed. Results of the 12-month pilot scale experiments showed that catalytic ozonation resulted in the effective removal of organic pollutants when backflushing was applied as an in-situ catalyst regeneration strategy. Read More

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http://dx.doi.org/10.1016/j.watres.2020.116090DOI Listing

TiO microspheres with cross-linked cyclodextrin coating exhibit improved stability and sustained photocatalytic degradation of bisphenol A in secondary effluent.

Water Res 2020 Jun 28;183:116095. Epub 2020 Jun 28.

Nanosystems Engineering Research Center for Nanotechnology Enabled Water Treatment (NEWT), United States; Department of Civil & Environmental Engineering, Houston, TX, 77005, United States. Electronic address:

Photocatalytic water treatment has significant potential to disinfect and degrade recalcitrant organic pollutants while minimizing the need to add chemicals, but current approaches have poor energy efficiency due, in part, to inefficient utilization of photo-generated reactive oxygen species (ROS). Organic coatings such as cyclodextrin (CD) can adsorb target contaminants and bring them close to the photocatalyst surface to enhance ROS utilization efficiency, but the coatings themselves are susceptible to ROS attack. Here, we report an ROS-resistant fluorinated CD polymer (CDP) that can both adsorb contaminants and resist degradation by ROS, yielding a more efficient material for "trap and zap" water treatment. Read More

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http://dx.doi.org/10.1016/j.watres.2020.116095DOI Listing

Co-culturing microalgae with endophytic bacteria increases nutrient removal efficiency for biogas purification.

Bioresour Technol 2020 Jul 2;314:123766. Epub 2020 Jul 2.

College of Biological, Chemical Science and Engineering, Jiaxing University, Jiaxing 314001, PR China.

Endophytic bacteria were isolated from Chlorella vulgaris and co-cultured with its host microalgae to determine whether this symbiotic system is suitable for purifying biogas and biogas slurry. Results showed that endophytic bacteria S395-1 and S395-2 belonged to different genera. Both strains promoted microalgae growth while improving photosynthetic performance, carbonic anhydrase activity, nutrient removal efficiency, and CO fixation. Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123766DOI Listing

Anaerobic membrane bioreactors (AnMBR) treating urban wastewater in mild climates.

Bioresour Technol 2020 Jul 2;314:123763. Epub 2020 Jul 2.

FCC Aqualia, S.A., Avenida Camino de Santiago, 40, 28050 Madrid, Spain.

Feasibility of an AnMBR demonstration plant treating urban wastewater (UWW) at temperatures around 25-30 °C was assessed during a 350-day experimental period. The plant was fed with the effluent from the pre-treatment of a full-scale municipal WWTP, characterized by high COD and sulfate concentrations. Biodegradability of the UWW reached values up to 87%, although a portion of the biodegradable COD was consumed by sulfate reducing organisms. Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123763DOI Listing

Voltammetric/UV-Vis study of temozolomide inclusion complexes with cyclodextrin derivatives.

Bioelectrochemistry 2020 Jun 26;136:107587. Epub 2020 Jun 26.

University of Warsaw Faculty of Chemistry, Pasteura 1, 02-093 Warsaw, Poland; Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Żwirki i Wigury 101, 02-089 Warsaw, Poland. Electronic address:

Temozolomide (TMZ) - a chemotherapeutic agent possessing cytotoxic activity is used in single or combined therapies of human glioma. Difficulties in these applications, connected with low solubility and stability of temozolomide lead us to study the inclusion complexes between TMZ, and three cyclodextrins: β-cyclodextrin (βCD), monodeoxy-6-monoamino-β-cyclodextrin hydrochloride (βCDamine), and β-cyclodextrin containing galactosamine and triazole ring in the side group (βCDgal). The voltammetric and spectroscopy studies showed the improvement of the drug solubility and formation of stable complexes. Read More

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http://dx.doi.org/10.1016/j.bioelechem.2020.107587DOI Listing

BES2019.

Bioelectrochemistry 2020 May 19;136:107554. Epub 2020 May 19.

School of Chemistry, & Ryan Institute, National University of Ireland Galway, Galway, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.bioelechem.2020.107554DOI Listing

The Anatomic Pathology laboratory adjustments in the era of COVID-19 pandemic: The experience of a laboratory in a Portuguese central hospital.

Ann Diagn Pathol 2020 Jul 1;48:151560. Epub 2020 Jul 1.

Anatomic Pathology Service, Pathology Department, Hospital and University Center of Porto, Largo Professor Abel Salazar, 4099-001 Porto, Portugal. Electronic address:

The coronavirus disease 2019 (COVID-19) pandemic has dramatically changed the world over the past weeks, with already 8,25 million infections and 445,000 deaths worldwide, leading to an unprecedented international global effort to contain the virus and prevent its spread. The emergence of novel respiratory viruses such as the SARS-CoV-2 creates dramatic challenges to the healthcare services, including surgical pathology laboratories, despite their extensive daily experience in dealing with biological and chemical hazards. Here, we cover important aspects on the knowledge on COVID-19 gathered during the first six months of the pandemic and address relevant issues on human biological sample handling in the Anatomic Pathology laboratory in the context of COVID-19 global threat. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151560DOI Listing

Cell death associated release of volatile organic sulphur compounds with antioxidant properties in chemical-challenged tobacco BY-2 suspension cultured cells.

J Plant Physiol 2020 Jul 2;251:153223. Epub 2020 Jul 2.

Wageningen University & Research, Horticulture and Product Physiology Group, Droevendaalsesteeg 1, P.O. Box 630, 6700AP, Wageningen, the Netherlands; Wageningen Food and Biobased Research, Bornse Weilanden 9, P.O. Box 17, 6700 AA Wageningen, the Netherlands. Electronic address:

The production of volatile organic compounds (VOCs) during programmed cell death (PCD) is still insufficiently studied and their implication in the process is not well understood. The present study demonstrates that the release of VOSCs with presumed antioxidant capacity (methanethiol, dimethylsulfide and dimethyldisulfide) accompanies the cell death in chemical-stressed tobacco BY-2 suspension cultured cells. The cells were exposed to cell death inducers of biotic nature mastoparan (MP, wasp venom) and camptothecin (CPT, alkaloid), and to the abiotic stress agent CdSO. Read More

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http://dx.doi.org/10.1016/j.jplph.2020.153223DOI Listing

Nonylphenol exposure affects mouse oocyte quality by inducing spindle defects and mitochondria dysfunction.

Environ Pollut 2020 Jul 1;266(Pt 1):114967. Epub 2020 Jul 1.

College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China. Electronic address:

Nonylphenol (NP) is a chemical raw material and intermediate which is mainly used in the production of surfactants, lubricating oil additives and pesticide emulsifiers. NP is reported to be toxic on the immune system, nervous system and reproductive system due to its binding to estrogen receptors. However, the toxicity of NP on mammalian oocyte quality remains unclear. Read More

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http://dx.doi.org/10.1016/j.envpol.2020.114967DOI Listing

KOH-activated porous biochar with high specific surface area for adsorptive removal of chromium (VI) and naphthalene from water: Affecting factors, mechanisms and reusability exploration.

J Hazard Mater 2020 Jun 23;401:123292. Epub 2020 Jun 23.

School of Resources and Environment, Northeast Agricultural University, Harbin 150030, China. Electronic address:

Herein, a high-performance porous biochar described as PBC was successfully synthesized by two-step pyrolysis of corn straw with chemical activation of KOH, and was employed for the elimination of Cr(VI) and naphthalene (NAP) from water. Benefiting from KOH activation, the PBC was found to possess huge specific surface area of 2183.80 m/g and many well-developed micropores with average particle size of 2. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123292DOI Listing

Assessing population exposure to phthalate plasticizers in thirteen Spanish cities through the analysis of wastewater.

J Hazard Mater 2020 Jun 22;401:123272. Epub 2020 Jun 22.

Department of Analytical Chemistry, Institute of Research on Chemical and Biological Analysis (IAQBUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

Phthalates are widely used plasticizers that produce endocrine-disrupting disorders. Quantifying exposure is crucial to perform risk assessments and to develop proper health measures. Herein, a wastewater-based epidemiology approach has been applied to estimate human exposure to six of the mostly used phthalates within the Spanish population. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123272DOI Listing

Impacts of carbon-based nanomaterials on nutrient removal in constructed wetlands: Microbial community structure, enzyme activities, and metabolism process.

J Hazard Mater 2020 Jun 22;401:123270. Epub 2020 Jun 22.

Key Laboratory of the Three Gorges Region's Eco-Environment, Ministry of Education, College of Environment and Ecology, Chongqing University, Campus B 83 Shabeijie, Shapingba, Chongqing, 400044, PR China; National Centre for International Research of Low-Carbon and Green Buildings, Chongqing University, Chongqing, 400044, PR China. Electronic address:

The increasing use of raw carbon-based nanomaterials (CBNs) will inevitably affect wastewater treatment systems. Constructed wetlands (CWs) are ecological wastewater treatment facilities and can intercept the vast particles pollutant, including CBNs. However, the impacts of CBNs on the treatment performance of CWs have no available knowledge. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123270DOI Listing

Ag-Pi/BiVO heterojunction with efficient interface carrier transport for photoelectrochemical water splitting.

J Colloid Interface Sci 2020 Jun 30;579:619-627. Epub 2020 Jun 30.

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China. Electronic address:

The limitation of pristine BiVO photoanode severely causes the high carrier recombination efficiency and low energy conversion efficiency in the photoelectrochemical (PEC) system. In this work, the Ag-Pi/BiVOn-n heterojunction has been rationally designed and fabricated for efficient PEC water splitting, through successive ionic layer adsorption reaction method. The built-in field of Ag-Pi/BiVO significantly promotes the separation efficiency of photogenerated carriers, benefiting for the participation of abundant holes in water oxidation. Read More

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http://dx.doi.org/10.1016/j.jcis.2020.06.108DOI Listing

Electrochemical hydrogen and oxygen evolution reactions from a cobalt-porphyrin-based covalent organic polymer.

J Colloid Interface Sci 2020 Jun 30;579:598-606. Epub 2020 Jun 30.

School of Energy & Power Engineering, School of Chemistry & Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China. Electronic address:

Covalent organic polymers have attracted much attention due to their high specific surface area, superlative porosity, and diversity in electronic structure. Herein, a novel porous cobalt-porphyrin-based covalent organic polymer (CoCOP) is fabricated through the Schiff-base condensation reaction, which is used as a difunctional electrocatalyst for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). The CoCOP possesses a high surface area and strong synergistic effect between the cobalt-porphyrins and the CN groups, resulting in efficient HER and OER performances. Read More

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http://dx.doi.org/10.1016/j.jcis.2020.06.109DOI Listing

Glycerol plasticisation of chitosan/carboxymethyl cellulose composites: Role of interactions in determining structure and properties.

Int J Biol Macromol 2020 Jul 6. Epub 2020 Jul 6.

International Institute for Nanocomposites Manufacturing (IINM), WMG, University of Warwick, Coventry CV4 7AL, United Kingdom. Electronic address:

Biopolymers such as chitosan and cellulose continue to attract much interest as they have many appealing characteristics such as biodegradability, biocompatibility, chemical versatility and natural functionality; however, many of their properties usually require further tailoring for specific purposes. This study shows that glycerol plasticisation and the addition of graphene oxide (GO) or reduced graphene oxide (rGO) altered the properties of chitosan and a chitosan/carboxymethyl cellulose (CMC) blend. For the chitosan/CMC matrix, GO or rGO was likely to disrupt polyelectrolyte complexation (PEC) between the two biopolymers, leading to weakened mechanical properties and increased surface hydrophilicity. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.07.004DOI Listing

Identifying early abdominal obesity risk in adolescents by telemedicine: a cross-sectional study in Greece.

Food Chem Toxicol 2020 Jul 6:111532. Epub 2020 Jul 6.

Center for Adolescent Medicine and UNESCO Chair on Adolescent Health Care, First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Aghia Sophia Children's Hospital, 1 Thivon Street, Athens, 11527, Greece. Electronic address:

Obesity and thus, lipotoxicity, is a major health risk factor. Modern exposure to environmental chemicals has contributed significantly to the obesity epidemic. The purpose of this study was to assess, via telemedicine and using bioelectrical impedance analysis (BIA) in schools, the levels of adiposity and other body composition parameters of Greek adolescents in relation with their metabolic syndrome (MetS) characteristics. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111532DOI Listing

Vaterite Submicron Particles Design for Photodynamic Therapy in Cells.

Photodiagnosis Photodyn Ther 2020 Jul 6:101913. Epub 2020 Jul 6.

Research and Development Institute - IPD. Vale do Paraíba University, UNIVAP. Av. Shishima Hifumi, 2911, CEP: 12244-000, São José dos Campos, SP, Brazil. Electronic address:

Background: Calcium carbonate (CaCO) is one of the most abundant materials in the world. It has several different crystalline phases as present in the minerals: calcite, aragonite and vaterite, which are anhydrous crystalline polymorphs. Regarding the preparation of these microparticles, the most important aspect is the control of the polymorphism, particle size and material morphology. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101913DOI Listing

Development of a next generation risk assessment framework for the evaluation of skin sensitisation of cosmetic ingredients.

Regul Toxicol Pharmacol 2020 Jul 6:104721. Epub 2020 Jul 6.

Cosmetics Europe, Avenue Herrmann Debroux 40, 1160, Brussels, Belgium. Electronic address:

All cosmetic products placed onto the market must undergo a risk assessment for human health to ensure they are safe for consumers, including an assessment of skin sensitisation risk. Historically, in vivo animal test methods were used to identify and characterise skin sensitisation hazard, however non-animal and other new approach methodologies (NAMs) are now the preferred and mandated choice for use in risk assessment for cosmetic ingredients. The experience gained over the last three decades on how to conduct risk assessments based upon NAMs has allowed us to develop a non-animal, next generation risk assessment (NGRA) framework for the assessment of skin sensitisers. Read More

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http://dx.doi.org/10.1016/j.yrtph.2020.104721DOI Listing

Development of nimesulide amorphous solid dispersions via supercritical anti-solvent process for dissolution enhancement.

Eur J Pharm Sci 2020 Jul 6:105457. Epub 2020 Jul 6.

Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Life and Pharmaceutical Sciences, Hainan University, Haikou, China. Electronic address:

Formulating amorphous solid dispersions (ASDs) is one of the most promising strategies to overcome solubility limitations in drug development. In this work, development of nimesulide (NIM) ASDs via supercritical anti-solvent (SAS) process was proposed, where the mixtures of dichloromethane (DCM) and methanol (MeOH) were selected as the liquid solvent, and the mixtures of hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) were the dispersing materials. The effects of NIM/HPMC/PVP (w/w/w) ratio and DCM/MeOH (v/v) ratio on particle solid-state properties were investigated to identify successful operating conditions. Read More

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http://dx.doi.org/10.1016/j.ejps.2020.105457DOI Listing

Human Articular Cartilage is Orthotropic where Microstructure, Micromechanics, and Chemistry Vary with Depth and Split-line Orientation.

Osteoarthritis Cartilage 2020 Jul 6. Epub 2020 Jul 6.

Department of Mechanical Engineering, University of Colorado, Boulder, CO; BioFrontiers Institute, University of Colorado, Boulder, CO; Biomedical Engineering Program, University of Colorado, Boulder, CO. Electronic address:

Objective: Quantitative, micrometer length scale assessment of human articular cartilage is essential to enable progress toward new functional tissue engineering approaches, including utilization of emerging 3D bioprinting technologies, and for improved computational modeling of the osteochondral unit. Thus the objective of this study was to characterize the structural organization, material properties, and chemical composition of human skeletally mature articular cartilage with respect to depth and defined morphological features: normal to the articulating surface, parallel to the split-line, and transverse to the split-line.

Method: Three samples from the lateral femoral condyles of 4 healthy adult donors (55-61 years old) were evaluated via histology, second harmonic generation, microindentation, and Raman spectroscopy. Read More

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http://dx.doi.org/10.1016/j.joca.2020.06.007DOI Listing

Glycosylated-Imidazole Aldoximes as Reactivators of Pesticides Inhibited AChE: Synthesis and In-vitro Reactivation Study.

Environ Toxicol Pharmacol 2020 Jul 6:103454. Epub 2020 Jul 6.

University of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, Hradec Kralove, Czech Republic; University Hospital, Biomedical Research Center, Sokolska 581, 50005, Hradec Kralove, Czech Republic. Electronic address:

The present armamentarium of commercially available antidotes provides limited protection against the neurological effects of organophosphate exposure. Hence, there is an urgent need to design and develop molecules that can protect and reactivate inhibited-AChE in the central nervous system. Some natural compounds like glucose and certain amino acids (glutamate, the anion of glutamic acid) can easily cross the blood brain barrier although they are highly polar. Read More

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http://dx.doi.org/10.1016/j.etap.2020.103454DOI Listing

Efficacy of favipiravir (T-705) against Crimean-Congo hemorrhagic fever virus infection in cynomolgus macaques.

Antiviral Res 2020 Jul 6:104858. Epub 2020 Jul 6.

Rocky Mountain Laboratories, NIAID/NIH, Hamilton, MT, USA.

Crimean-Congo hemorrhagic fever virus (CCHFV) is a widely distributed hemorrhagic fever virus found throughout Eastern Europe, Africa, the Middle East and Asia. It is spread through bites from infected ticks, animal husbandry and can also be acquired in the healthcare setting during care of infected patients. In humans, CCHFV can cause a sudden onset of a non-specific febrile illness that can rapidly progress to severe hemorrhagic manifestations. Read More

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http://dx.doi.org/10.1016/j.antiviral.2020.104858DOI Listing

Two kinds of sterols extracted from Leucocalocybe mongolica induced HepG2 cell apoptosis and their antitumor effect in H22 tumor-bearing mice and their possible mechanism.

Steroids 2020 Jul 6:108692. Epub 2020 Jul 6.

Key Laboratory of Medicinal Fungal Resources and Development and Utilization, Jilin Agricultural University, Changchun 130118, China. Electronic address:

Sterols are one of the main components of medicinal fungi with antitumor effect. In this study, Ergosta-4, 6, 8(14), 22-tetraen-3-one (ET) and (22E, 24R)-ergosta-7, 22-dien-3β, 5α, 6β-triol (ED) were obtained from Leucocalocybe mongolica, which are the first time to study the induction of HepG2 cell apoptosis and the anti-tumor effect and related mechanism of H22 tumor-bearing mice METHOD: The chemical structures were defined by IR and NMR. In vitro, the cytotoxicity assay used was the CCK8 assay. Read More

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http://dx.doi.org/10.1016/j.steroids.2020.108692DOI Listing

Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies.

Cell 2020 Jun 24. Epub 2020 Jun 24.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. Electronic address:

Neutralizing antibody responses to coronaviruses mainly target the receptor-binding domain (RBD) of the trimeric spike. Here, we characterized polyclonal immunoglobulin Gs (IgGs) and Fabs from COVID-19 convalescent individuals for recognition of coronavirus spikes. Plasma IgGs differed in their focus on RBD epitopes, recognition of alpha- and beta-coronaviruses, and contributions of avidity to increased binding/neutralization of IgGs over Fabs. Read More

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http://dx.doi.org/10.1016/j.cell.2020.06.025DOI Listing

A Region of UNC-89 (Obscurin) Lying between Two Protein Kinase Domains Is a Highly Elastic Spring Required for Proper Sarcomere Organization.

J Mol Biol 2020 Jul 6. Epub 2020 Jul 6.

Department of Pathology, Emory University, Atlanta, Georgia 30322. Electronic address:

In C. elegans, unc-89 encodes a set of giant multi-domain proteins (up 8081 residues) localized to the M-lines of muscle sarcomeres and required for normal sarcomere organization and whole-animal locomotion. Multiple UNC-89 isoforms contain two protein kinase domains. Read More

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http://dx.doi.org/10.1016/j.jmb.2020.06.024DOI Listing

Mechanistic studies on the drug metabolism and toxicity originating from cytochromes P450.

Drug Metab Rev 2020 Jul 9:1-29. Epub 2020 Jul 9.

Department of Medicinal Chemistry and Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar, Punjab, India.

Cytochromes P450 are oxidizing enzymes; a few families of cytochromes P450 are implicated in drug metabolism. These enzymatic reactions involve many processes including (i) prodrug to drug conversion, (ii) easy excretion of drug, (iii) generation of reactive metabolites, many of which cause toxicity. In this review, the fundamental biochemical mechanisms associated with the conversion of drugs into the useful or toxic metabolites have been discussed. Read More

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http://dx.doi.org/10.1080/03602532.2020.1765792DOI Listing

Substituent Effect Induces Emission Modulation of Stilbene Photoswitches by Spatial Tuning of the N/B Electronic Constraints.

Org Lett 2020 Jul 9. Epub 2020 Jul 9.

Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, School of Chemistry and Chemical Engineering, Beijing Institute of Technology of China, Beijing 102488, People's Republic of China.

We present a family of stilbene derivatives (-) ortho-functionalized with an electron donor and acceptor. Their emission was tuned by donor substitutions, dictating charge transfer dependent on the N···B spatial separation. The steric reduction of substituents on N leads to stronger emission responses upon trans-to-cis photoisomerization. Read More

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http://dx.doi.org/10.1021/acs.orglett.0c01777DOI Listing

A Strategy for the Construction of Triply Interlocked Organometallic Cages by Rational Design of Poly-NHC Precursors.

J Am Chem Soc 2020 Jul 9. Epub 2020 Jul 9.

Three-dimensional (3D) triply interlocked catenanes are a family of chemical topologies that consist of two identical, mechanically interlocked coordination cage components with intriguingly complex structures. Although only a few successful constructions of 3D interlocked catenanes have been achieved to date via metal-mediated assembly, these complex structures have thus far only been targeted by metal-nitrogen/oxygen coordination techniques. Here, taking advantage of rational ligand design, we report the efficient construction of a series of 3D triply interlocked [2]catenanes of the formula [Ag3L2]2, wherein the metal ions exclusively form bonds to N-heterocyclic carbene (NHC) units, and their subsequent transmetalation to the corresponding [Au3L2]2 gold analogues. Read More

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http://dx.doi.org/10.1021/jacs.0c06470DOI Listing

Ultrafast Excited State Dynamics of Tricarbocyanine Dyes Probed by Two-Dimensional Electronic Spectroscopy: Polar Solvation vs Photoisomerization.

J Phys Chem B 2020 Jul 9. Epub 2020 Jul 9.

Photophysical properties of tricarbocyanine dyes in various solvents have been widely investigated using a variety of spectroscopic tools. However, presence of several ground-state isomers and interconversion between these isomers on ultrafast time-scale upon photo-excitation render unambiguous assignment of spectral features quite difficult. In this work, ultrafast excited state dynamics of two tricarbocyanine dyes, DNTTCI and IR140, in ethanol and ethylene glycol is studied by two-dimensional electronic spectroscopy (2DES). Read More

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http://dx.doi.org/10.1021/acs.jpcb.0c01333DOI Listing

Effect of Potassium Nitrate and Boric Acid on the Bond Strength of Veneering Ceramics to Zirconia.

Eur J Prosthodont Restor Dent 2020 Jul 7. Epub 2020 Jul 7.

Department of Phsyics, Faculty of Arts and Science, University of Ondokuz Mayis, Samsun, Turkey.

In this study, the effects of boric acid addition to the veneer ceramics and treatment of the ceramic cores immersed in potassium nitrate solution were evaluated to reduce the micro cracks that may occur in the internal structure of the ceramic, increase the mechanical properties and improve the chemical bonding strength of core ceramics. In the data obtained after the experiment, the average MPa values showed statistically significant differences according to the groups (p⟨0.001). Read More

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http://dx.doi.org/10.1922/EJPRD_Sasany203007DOI Listing

Beyond polysulfides shuttle and Li dendrite formation: addressing the sluggish S redox kinetics for practical high energy Li-S batteries.

Angew Chem Int Ed Engl 2020 Jul 9. Epub 2020 Jul 9.

Argonne National Laboratory, Chemical Sciences & Engineering Division, 9700 South, Cass Ave, 60439, Argonne, UNITED STATES.

Electrolyte modulation has been reported to simultaneously suppress polysulfide shuttle effect and lithium dendrite formation of lithium-sulfur (Li-S) batteries. However, the sluggish S redox kinetics, especially under high S loading and lean electrolyte operation, has been intensively ignored, which dramatically limits the cycle life and energy density of practical Li-S pouch cells. Herein, we demonstrate that a rational combination of selenium doping, core-shell hollow host structure, and fluorinated ether electrolytes enables ultrastable Li stripping/plating and essentially no polysulfide shuttle as well as fast redox kinetics. Read More

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http://dx.doi.org/10.1002/anie.202007159DOI Listing

Response surface optimization of phenolic compounds extraction from camu-camu (Myrciaria dubia) seed coat based on chemical properties and bioactivity.

J Food Sci 2020 Jul 9. Epub 2020 Jul 9.

Department of Food Engineering, State University of Ponta Grossa, Ponta Grossa, Brazil.

Food companies should comply with the requirements of a zero-waste concept to adapt to the circular economy requirements. In fruit companies, usually seeds are discarded without proper utilization and extraction of the bioactive compounds. Fruit seeds are sources of chemical compounds that can be extracted, studied, and applied in high value-added products. Read More

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http://dx.doi.org/10.1111/1750-3841.15327DOI Listing

Circulating and tissue biomarkers as predictors of bromine gas inhalation.

Ann N Y Acad Sci 2020 Jul 9. Epub 2020 Jul 9.

Department of Anesthesiology and Perioperative Medicine, the University of Alabama at Birmingham, Birmingham, Alabama.

The threat from deliberate or accidental exposure to halogen gases is increasing, as is their industrial applications and use as chemical warfare agents. Biomarkers that can identify halogen exposure, diagnose victims of exposure or predict injury severity, and enable appropriate treatment are lacking. We conducted these studies to determine and validate biomarkers of bromine (Br ) toxicity and correlate the symptoms and the extent of cardiopulmonary injuries. Read More

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http://dx.doi.org/10.1111/nyas.14422DOI Listing

Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer.

PLoS One 2020 9;15(7):e0234103. Epub 2020 Jul 9.

Cyclacel Limited, Dundee, United Kingdom.

Cyclin-dependent kinases (CDKs) contribute to the cancer hallmarks of uncontrolled proliferation and increased survival. As a result, over the last two decades substantial efforts have been directed towards identification and development of pharmaceutical CDK inhibitors. Insights into the biological consequences of CDK inhibition in specific tumor types have led to the successful development of CDK4/6 inhibitors as treatments for certain types of breast cancer. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234103PLOS

Determination of reference intervals for common chemistry and immunoassay tests for Kenyan adults based on an internationally harmonized protocol and up-to-date statistical methods.

PLoS One 2020 9;15(7):e0235234. Epub 2020 Jul 9.

Division of Chemical Pathology, Department of Pathology, Stellenbosch University, Cape Town, South Africa.

Background: Due to a lack of reliable reference intervals (RIs) for Kenya, we set out to determine RIs for 40 common chemistry and immunoassay tests as part of the IFCC global RI project.

Methods: Apparently healthy adults aged 18-65 years were recruited according to a harmonized protocol and samples analyzed using Beckman-Coulter analyzers. Value assigned serum panels were measured to standardize chemistry results. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235234PLOS

Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection.

J Clin Invest 2020 Jul 9. Epub 2020 Jul 9.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, United States of America.

Alarmins, sequestered self-molecules containing damage-associated molecular patterns, are released during tissue injury to drive innate immune cell pro-inflammatory responses. Whether endogenous negative regulators controlling early immune responses are also released at the site of injury is poorly understood. Herein, we establish that the stromal cell-derived alarmin interleukin-33 (IL-33) is a local factor that directly restricts the pro-inflammatory capacity of graft infiltrating macrophages early after transplantation. Read More

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http://dx.doi.org/10.1172/JCI133008DOI Listing
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