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    851 results match your criteria Cheilitis Granulomatosa Miescher-Melkersson-Rosenthal Syndrome

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    Treatment of orofacial granulomatosis: a case report.
    J Med Case Rep 2017 Oct 25;11(1):300. Epub 2017 Oct 25.
    Department of Gastroenterology and Hepatology, University of Illinois Peoria Campus, OSF Saint Francis Medical Center, Peoria, IL, 61637, USA.
    Background: Orofacial granulomatosis is a relatively recent term coined by Wiesenfield et al. in 1985 to define granulomatous lesions of oral mucosa without intestinal involvement. When it presents in a triad encompassing facial nerve palsy, lip swelling, and fissured or furrowed tongue it is called Melkersson-Rosenthal syndrome while monosymptomatic or oligosymptomatic forms are referred to as granulomatous cheilitis. Read More

    Melkersson-rosenthal syndrome: a case report.
    J Istanb Univ Fac Dent 2017 2;51(1):42-45. Epub 2017 Jan 2.
    Department of Dentomaxillofacial Radiology, Gazi University Faculty of Dentistry Turkey.
    Melkersson-Rosenthal Syndrome (MRS) is a rare disorder consisting of a triad of persistent or recurrent orofacial edema, relapsing facial paralysis and fissured tongue. It is rarely possible to observe all aspects of the classical triad at the same time, since these symptoms may appear in different times of life cycle. The most common symptom is orofacial edema. Read More

    Orofacial granulomatosis in a 12-year-old girl successfully treated with intravenous pulse corticosteroid therapy and chloroquine.
    Pediatr Dermatol 2017 Nov 21;34(6):e324-e327. Epub 2017 Sep 21.
    Division of Pediatric Dermatology, Clinic of Dermatovenereology, Clinical Center of Serbia, Belgrade, Serbia.
    Orofacial granulomatosis, a rare disease in childhood, is characterized by orofacial swelling in the absence of systemic disease. We report the case of a 12-year-old girl with asymptomatic erythematous infiltration of her upper lip, cheeks, and chin that had persisted for more than 2 years; biopsy confirmed granuloma formation. Because a large area was affected, intralesional corticosteroids were inappropriate and six cycles of 3-day intravenous pulse corticosteroid therapy (dexamethasone 1. Read More

    Miescher's cheilitis: Surgical management and long term outcome of an extremely severe case.
    Int J Surg Case Rep 2017 30;31:241-244. Epub 2017 Jan 30.
    Department of Medical Geriatric-Immunoallergology Unit, Careggi University Hospital, Florence, Italy.
    Introduction: Miescher's cheilitis is clinically characterized by persistent swelling of the lip(s). Its pathogenesis is still unknown. Histopathologically is characterized by sub-epithelial edema, increased number of dilated lymphatic vessels and an inflammatory infiltrate and/or non-caseating/non- necrotic granulomas. Read More

    Melkersson-Rosenthal Syndrome: A Case Report With a Psychosomatic Perspective.
    Adv Mind Body Med 2017 Winter;31(1):14-17
    Context • The Melkersson-Rosenthal syndrome (MRS) is a rare condition characterized by a triad of symptoms: (1) recurrent and/or persistent orofacial swelling, (2) recurrent facial paralysis, and (3) a fissured tongue. Although various contributing factors have been suggested, the etiology and mechanisms of the syndrome have not been fully elucidated. Objective • The aim of the current study was to examine for the first time some psychosomatic aspects of the syndrome and to evaluate the benefits of a brief psychotherapeutic process in which the research team worked to reintegrate the complex bio-psycho-social functioning of the patient. Read More

    Granulomatous & histiocytic dermatitides.
    Semin Diagn Pathol 2017 May 14;34(3):301-311. Epub 2016 Dec 14.
    Section of Dermatopathology, Division of Surgical & Cytological Pathology, University of Virginia Medical Center, Charlottesville, VA, USA. Electronic address:
    Granulomas of the skin may be classified in several ways. They are either infectious or non-infectious in character, and they contain areas of necrobiosis or necrosis, or not. Responsible infectious agents may be mycobacterial, fungal, treponemal, or parasitic organisms, and each case of granulomatous dermatitis should be assessed histochemically for those microbes. Read More

    [A patient with Melkersson-Rosenthal syndrome].
    Ned Tijdschr Geneeskd 2016 ;160(0):D427
    Leids Universitair Medisch Centrum, afd. Neurologie, Leiden.
    Background: Melkersson-Rosenthal syndrome (MRS) is a relatively rare syndrome characterised by the clinical triad of persisting or recurrent facial oedema, recurrent peripheral facial palsy, and a fissured tongue.

    Case Description: A 30-year-old male patient presented with a left peripheral facial palsy spreading to the right side of the face. The left-sided facial paralysis recurred twice after initial recovery. Read More

    [Melkersson Rosenthal syndrome. Report of two pediatric cases].
    Arch Argent Pediatr 2016 Aug 1;114(4):e224-7. Epub 2016 Aug 1.
    Residencia de Otorrinolaringología Infantil, Hospital General de Niños Pedro de Elizalde, Ciudad Autónoma de Buenos Aires, Argentina.
    Melkersson Rosenthal syndrome is a very infrequent disease of unknown etiology, chronic and progressive course, with neurocutaneous disease that affects the orofacial innervation and mucocutaneous tissues with non-caseating granulomatous infiltration. Clinically, it is characterized by the diagnostic triad: recurrent edema of lips and/or face; recurrent and alternating acute peripheral facial paralysis and scrotal or geographic tongue. The condition generally presents as oligosymptomatic or monosymptomatic form. Read More

    Orofacial granulomatosis.
    Clin Dermatol 2016 Jul-Aug;34(4):505-13. Epub 2016 Mar 3.
    Department of Dermatology, Mayo Clinic, Scottsdale, AZ.
    Orofacial granulomatosis (OFG) is an uncommon chronic granulomatous condition with a multifactorial etiology and pathogenesis. Genetic, immunologic, allergic, and infectious mechanisms have been implicated. OFG is often used as a descriptor to encompass all entities with orofacial swelling and histologic evidence of noncaseating granulomas. Read More

    Bilateral Facial Paralysis: A 13-Year Experience.
    Plast Reconstr Surg 2016 Oct;138(4):879-87
    Boston, Mass. From the Department of Otolaryngology, Massachusetts Eye and Ear Infirmary and Harvard Medical School.
    Background: Bilateral facial palsy is a rare clinical entity caused by myriad disparate conditions requiring different treatment paradigms. Lyme disease, Guillain-Barré syndrome, and leukemia are several examples. In this article, the authors describe the cause, the initial diagnostic approach, and the management of long-term sequelae of bilateral paralysis that has evolved in the authors' center over the past 13 years. Read More

    Recurrent Facial Palsy and Electrophysiological Findings in Oligosymptomatic Melkersson Rosenthal Syndrome.
    Indian J Pediatr 2016 Oct 11;83(10):1188-90. Epub 2016 May 11.
    Unit of Pediatric Neurology and Neurodevelopment, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
    Melkersson Rosenthal Syndrome is a rare neuro-mucocutaneous disorder characterized by the classic triad of facial swelling, recurrent facial nerve palsy and fissured tongue. The clinical course is usually progressive, and etiology is unknown. The authors describe oligosymptomatic Melkersson Rosenthal Syndrome in a young girl presenting sequentially with recurrent, metachronous facial nerve palsy and hemifacial swelling in early childhood followed by fissuring in the tongue in late-childhood. Read More

    [Macrocheilia revealing an acute promyelocytic leukemia].
    Rev Stomatol Chir Maxillofac Chir Orale 2016 Jun 22;117(3):161-3. Epub 2016 Apr 22.
    Service de chirurgie maxillofaciale et stomatologie, hôpital Pitié-Salpêtrière, AP-HP, 75013 Paris, France; UPMC université Paris 06, 75005 Paris, France.
    Introduction: Macrocheilia is a rare presentation for acute promyelocytic leukemia (APL).

    Case Report: A 18 year-old man was referred to our department for an acute swollen lower lip, multiple swollen cervical lymph nodes and spontaneous gum bleeding. The diagnosis of APL was made and the treatment was rapidly started in an intensive care unit. Read More

    Melkersson-Rosenthal Syndrome with Genitalia Involved in a 12-Year-Old Boy.
    Ann Dermatol 2016 Apr 31;28(2):232-6. Epub 2016 Mar 31.
    Department of Dermatology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
    Melkersson-Rosenthal syndrome (MRS) is an uncommon granulomatous disease characterized by the triad of relapsing facial paralysis, orofacial swelling, and fissured tongue. Genital swelling in MRS is rarely reported. We presented the first case of complete MRS with genital swelling in a child. Read More

    Case report of cheilitis granulomatosa and joint complaints as presentation of Crohn's disease.
    Clin J Gastroenterol 2016 Apr 26;9(2):73-8. Epub 2016 Mar 26.
    Department of Pediatric Gastroenterology and Nutrition, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
    Cheilitis granulomatosa is characterized by granulomatous lip swelling. We report a case of a 13-year-old girl who presented with orofacial swelling and arthralgia, who eventually was diagnosed with Crohn's disease, which was successfully treated with infliximab and azathioprine combination therapy. Recurrent or persistent orofacial swelling should prompt consideration of cheilitis granulomatosa, and further diagnostic evaluation to exclude the presence of Crohn's disease seems warranted. Read More

    CLINICAL CHARACTERISTICS AND TREATMENT OF MELKERSSON-ROSENTHAL SYNDROME--OVERVIEW OF SIX PATIENTS.
    Med Pregl 2015 Nov-Dec;68(11-12):401-4
    Introduction: Melkersson-Rosenthal syndrome is a rare disease of unknown etiology. Histopathologically, it presents as granulomatous cheilitis. From laboratory aspect, it is a nonspecific, differential diagnostically and therapeutically complex condition. Read More

    Resident Rounds: Part III--Case Report: Crohn's Disease Presenting as Granulomatous Cheilitis.
    J Drugs Dermatol 2016 Feb;15(2):251-2
    Cutaneous Crohn's is a rare extra-intestinal manifestation of inflammatory bowel disease seen in a select group of patients, in which cutaneous lesions similar to those of the intestinal illness appear distant from the gastrointestinal tract. Oral findings may be found in up to 60% of patients with extra-intestinal Crohn's and may appear as the initial symptom underlying disease. We present a case of a 17-year-old male presenting with granulomatous chelitis of the lower lip who was unaware of the underlying diagnosis of Crohn's disease (CD). Read More

    Successful treatment of Melkersson-Rosenthal syndrome with dapsone: a case report and review of the literature.
    Dermatol Online J 2016 Oct 15;22(10). Epub 2016 Oct 15.
    Department of Dermatology, Bezmialem Vakif University, Fatih/İstanbul, Turkey.
    Melkersson-Rosenthal syndrome (MRS) is a rare disease characterized by a triad of relapsing or persistent orofacial edema, recurrent lower motor neuron facial nerve palsy and fissured tongue. Acute, painless, non-erythematosus orofacial edema is observed in all patients. We report a case of a 13-year-old girl who presented with a 2-year history of swelling of the upper lip, facial paralysis, and fissured tongue; she was treated successfully with dapsone. Read More

    Melkersson-Rosenthal syndrome as an early manifestation of mixed connective tissue disease.
    Eur J Med Res 2015 Dec 23;20:100. Epub 2015 Dec 23.
    Speciality Hospital in Gorlice, ul. Wegierska 21, 38-300, Gorlice, Poland.
    Purpose Of Review: We aim to illustrate the potential viability of MCTD as an underlying aetiology of Melkersson-Rosenthal syndrome. The case is probably the first description available in the literature of the Melkersson-Rosenthal as an early manifestation of mixed connective tissue disease.

    Recent Findings: The Melkersson-Rosenthal syndrome consists of a triad of recurrent lip and/or face swelling, fissured tongue, and intermittent facial palsy. Read More

    [Cheilitis: Diagnosis and treatment].
    Presse Med 2016 Feb 8;45(2):240-50. Epub 2015 Dec 8.
    CHU de Tours, université François-Rabelais, service de dermatologie, 37044 Tours, France; ISP 1282, Inra, université de Tours, 37200 Tours, France. Electronic address:
    The whole examination of oral cavity, other mucosae and skin is required when managing a cheilitis. Irritants (climatic, mechanical, caustic agents.. Read More

    Melkersson-Rosenthal Syndrome with Orofacial Swelling and Recurrent Lower Motor Neuron Facial Nerve Palsy: A Case Report and Review of the Literature.
    Case Rep Otolaryngol 2015 9;2015:214946. Epub 2015 Nov 9.
    Warrawong Accident and Medical Center, King Street, Westfield, Warrawong, NSW 2502, Australia.
    Melkersson-Rosenthal Syndrome (MRS) is a rare otoneurologic condition, which is poorly understood and often underdiagnosed. Etiology and incidence are unclear, although infectious, inflammatory, and genetic causes have been implicated. Recurrent facial nerve palsy, facial swelling, and fissured tongue are the symptoms and signs of this condition. Read More

    Chronic lip swelling as the sole presentation of Crohn's disease: three case reports.
    Turk J Pediatr 2015 Jan-Feb;57(1):98-101
    3rd Department of Pediatrics, University of Athens Medical School, Athens, Greece.
    Chronic lip swelling may be a clinical sign of a systemic disease, such as Crohn's. We report two cases of children in Greece where the chronic lip swelling was not only the initial, but the sole clinical symptom of Crohn's, and another case with only granulomatous cheilitis up to now. All lip biopsies revealed granulomatous cheilitis. Read More

    Cutaneous leishmaniasis mimicking granulomatous cheilitis and treated successfully with oral fluconazole in a boy.
    Ann Parasitol 2015 ;61(3):197-9
    Department of Dermatology, Faculty of Medicine, Mustafa Kemal University, İskenderun St., Hatay 31100, Turkey.
    Cutaneous leishmaniasis is a protozoan infectious disease and widespread in Mediterranean basin including Turkey. Lesions usually start with erythematous papules, gradually enlarges and afterwards it ulcerates. We present a 12-year-old boy with diffuse persistent lip swelling mimicking granulomatous cheilitis. Read More

    Cheilitis granulomatosa associated with lupus erythematosus discoid and treated with methotrexate: report of a case.
    An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):200-2
    Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milano, IT.
    We present the rare case of a 47-year-old patient, suffering from cheilitis granulomatosa and lupus erythematosus discoid: this association is really exceptional because only once reported in English literature. In addition, the treatment of cheilitis granulomatosa is a challenge for the dermatologist: the gold standard, represented by steroids, is in fact designed as a short-time option. Our report confirms the good efficacy of methotrexate as a steroid-sparing agent. Read More

    Clinicopathological significance of Melkersson-Rosenthal syndrome.
    BMJ Case Rep 2015 Jul 31;2015. Epub 2015 Jul 31.
    Department of Pedodontics and Preventive Dentistry, Karnavati School of Dentistry, Gandhinagar, Gujarat, India.
    Melkersson-Rosenthal syndrome (MRS) classically shows a triad of orofacial swelling, fissured tongue and facial palsy, more commonly the oligosymptomatic form. The orofacial swelling is characterised by swollen reddish-brown non-pruritic lips and facial oedema. In one-third to one half of patients, fissured tongue is seen, which also aids in diagnosis. Read More

    Obsessive-compulsive disorder concurrent with Melkersson-Rosenthal Syndrome: a case report.
    Gen Hosp Psychiatry 2015 Sep-Oct;37(5):497.e7-9. Epub 2015 Jun 16.
    Department of Radiology, Konya Training and Research Hospital, Konya, Turkey. Electronic address:
    Objective: To describe a case of obsessive-compulsive disorder (OCD) comorbid with Melkersson-Rosenthal Syndrome (MRS).

    Methods: We present a case study of comorbid OCD and MRS in a 13-year-old girl.

    Results: She admitted to doubt obsessions and a control compulsion. Read More

    Orofacial Granulomatosis.
    Dermatol Clin 2015 Jul 6;33(3):433-46. Epub 2015 May 6.
    Oral Medicine Unit, UCL Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WC1X 8LD, UK; NIHR University College London Hospitals Biomedical Research Centre, Maple House, Suite A, 1st floor, 149 Tottenham Court Road, London W1T 7DN, UK; Oral Medicine Unit, Eastman Dental Hospital, University College London Hospitals Trust, 256 Gray's Inn Road, London WC1X 8LD, UK. Electronic address:
    Orofacial granulomatosis (OFG) is an uncommon chronic inflammatory disorder of the orofacial region. It is characterized by subepithelial noncaseating granulomas and has a spectrum of possible clinical manifestations ranging from subtle oral mucosal swelling to permanent disfiguring fibrous swelling of the lips and face. Etiopathogenesis is unknown. Read More

    Recurrent facial palsy in Melkersson Rosenthal syndrome: total facial nerve decompression is effective to prevent further recurrence.
    Am J Otolaryngol 2015 May-Jun;36(3):334-7. Epub 2014 Dec 4.
    The Center of Clinical Aviation Medicine, General Hospital of Air Force, Beijing, P.R.C. Electronic address:
    Objective: To study the role of total facial nerve decompression in preventing further recurrence of facial palsy in Melkersson Rosenthal syndrome (MRS).

    Methods: Total facial nerve decompression was performed on nine patients with recurrent facial palsy in MRS, and prednisolone treatment was given to 6 cases who declined surgery. They were incorporated into surgery group and control group, respectively. Read More

    Functional and Therapeutic Indications of Liposuction: Personal Experience and Review of the Literature.
    Ann Plast Surg 2015 Aug;75(2):231-45
    From the *Division of Plastic, Reconstructive and Aesthetic Surgery, American University of Beirut Medical Center, Beirut, Lebanon; †Toulouse University, and ‡Clinique du Parc, Toulouse, France.
    Liposuction is the most common cosmetic surgical procedure worldwide. It has evolved from being designed primarily for body contouring to becoming essential adjunct to various other aesthetic procedures, greatly enhancing their outcome. Despite its hard clear differentiation between an aesthetic and therapeutic indication for some pathologic conditions, liposuction has been increasingly applied to a gamut of disorders as a therapeutic tool or to improve function. Read More

    Orofacial granulomatosis in children: think about Crohn's disease.
    Dig Liver Dis 2015 Apr 30;47(4):338-41. Epub 2014 Dec 30.
    Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy; University of Trieste, Trieste, Italy. Electronic address:
    Background: The term orofacial granulomatosis is conventionally used to describe patients with granulomatous lesions affecting the orofacial tissues, in absence of intestinal lesions. Lip swelling and facial swelling are the most common clinical signs. Despite the fact that histologically it is not distinguishable from Crohn's disease, and that both diseases have a chronic/recurrent course, the relationship between orofacial granulomatosis and Crohn's disease is still debated. Read More

    Orofacial granulomatosis: clinical signs of different pathologies.
    Med Princ Pract 2015 9;24(2):117-22. Epub 2015 Jan 9.
    Department of Clinical and Experimental Medicine, Foggia University, Foggia, Italy.
    Orofacial granulomatosis (OFG) is an uncommon disease characterized by persistent or recurrent soft tissue enlargement, oral ulceration and a variety of other orofacial features. It could be an oral manifestation of a systemic disease. For a correct differential diagnosis, local and systemic conditions characterized by granulomatous inflammation should be excluded using appropriate clinical and laboratory investigations. Read More

    Idiopathic orofacial granulomatosis - a diagnostic and treatment challenge.
    J Clin Diagn Res 2014 Nov 20;8(11):ZD07-10. Epub 2014 Nov 20.
    Associate Professor, Department of Oral Medicine and Radiology, Tagore Dental College and Hospital , Chennai, India .
    Orofacial granulomatosis is an uncommon disease, usually presenting as recurrent or persistent swelling of the soft tissues, predominantly lips - termed as Cheilitis Granulomatosa. Though various aetiological factors like foreign body reactions, infections, Crohn's disease and Sarcoidosis have been implicated in the disease process. Delayed Hypersensitivity reaction with a predominant Th1-mediated immune response provide further evidence to the etiopathogenesis in Orofacial granulomatosis. Read More

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