936 results match your criteria Cheilitis Granulomatosa Miescher-Melkersson-Rosenthal Syndrome


Rare diagnosis of Melkersson-Rosenthal syndrome in a paediatric patient.

BMJ Case Rep 2021 Jun 11;14(6). Epub 2021 Jun 11.

Pediatrics, Medical Center Navicent Health, Macon, Georgia, USA.

Melkersson-Rosenthal syndrome (MRS) is a rare neurocutaneous syndrome characterised by the triad of recurrent orofacial swelling, facial nerve palsy and fissured tongue. This diagnosis is particularly rare in children. We aim to increase awareness of the syndromic association of these clinical features since most patients present with a monosymptomatic form, reiterating the importance of detailed history and thorough physical examination, for the timely identification of these patients. Read More

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Chronic macrocheilia: a clinico-etiological series of 47 cases.

Int J Dermatol 2021 Jun 3. Epub 2021 Jun 3.

Department of Dermatology, Charles Nicolle Hospital, Tunis, Tunisia.

Background: Macrocheilia is an inflammatory disfiguring condition responsible for the swelling of the lips. This multi-etiological entity represents a diagnostic and therapeutic challenge. Published data on macrocheilia is scarce, often limited to granulomatous cheilitis. Read More

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A case of orofacial granulomatosis evolving into Melkersson Rosenthal syndrome in a child treated with a steroid free regimen of Clofazimine and Minocycline.

Dermatol Ther 2021 May 27:e15009. Epub 2021 May 27.

Department of Pathology, Dr Ram Manohar Lohia Hospital and ABVIMS, New Delhi, India.

Orofacial granulomatosis (OFG) is a rare disorder with varied etiological, immunological and infectious mechanisms implicated and is believed to be a umbrella term which includes Melkersson Rosethal syndrome (MRS). We describe a 17 year old female who was diagnosed with OFG and was successfully treated with a combination of minocycline and clofazimine without oral steroids with significant improvement within 1 month of therapy. Read More

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Recurrent facial palsy and fissured tongue.

Eur J Intern Med 2021 May 18. Epub 2021 May 18.

Yong Loo Lin School of Medicine, National University of Singapore, and Division of Neurology, National University Hospital, Singapore. Electronic address:

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Orofacial granulomatosis: Clinical and therapeutic features in an Italian cohort and review of the literature.

Allergy 2021 Feb 28. Epub 2021 Feb 28.

Department of Translational Medical Sciences, Allergy and Clinical Immunology, Center for Basic and Clinical Immunology Research (CISI), WAO Center of Excellence, University of Naples Federico II, Naples, Italy.

Background: Orofacial granulomatosis (OFG) is characterized by granulomatous inflammation of the soft tissues of maxillofacial region. We explored OFG patients from 10 different Italian centers and summarized the most recent literature data.

Methods: A review of patients with OFG was carried out. Read More

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February 2021

[Recurrent peripheral facial nerve palsy].

Rev Alerg Mex 2020 Oct-Dec;67(4):421-424

Hospital Universitario de Cabueñes, Servicio de Pediatría, Gijón, España.

Background: Melkersson-Rosenthal syndrome is a rare disorder that is characterized, in its full form, by recurrent facial nerve palsy, fissured tongue, and orofacial edema. Most cases present as oligosymptomatic or monosymptomatic forms. Its etiology is still unknown and its course is chronic and it may be progressive. Read More

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February 2021

Clinical Profile of Melkersson-Rosenthal Syndrome/Orofacial Granulomatosis: A Review of 51 Patients.

J Cutan Med Surg 2021 Feb 11:1203475421995132. Epub 2021 Feb 11.

Department of Dermatology, Medical School, Av. Dr. Eneas de Carvalho Aguiar 255, Brazil.

Background: Melkersson-Rosenthal syndrome (MRS) is a rare disease characterized by the triad of granulomatous cheilitis, fissured tongue, and facial paralysis. Publications concerning large series are rare in the literature.

Objectives: To describe the clinical and histopathological characteristics of patients with complete and oligosymptomatic forms of MRS. Read More

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February 2021

Presentation of Bilateral Facial Paralysis in Melkersson-Rosenthal Syndrome.

Case Rep Neurol Med 2021 6;2021:6646115. Epub 2021 Jan 6.

Duke University, Durham, NC, USA.

. Melkersson-Rosenthal syndrome (MRS) is a neuromucocutaneous disorder characterized by the following classic symptom triad: peripheral facial paralysis, orofacial edema, and scrotal or fissured tongue. It is rare, and since most of the patients are oligo- or monosymptomatic, it makes it difficult to diagnose. Read More

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January 2021

Isolated bilateral eyelid edema in Melkersson-Rosenthal syndrome.

J Cutan Pathol 2021 Feb;48(2):203-206

Departments of Dermatology and Laboratory Medicine and Pathology, Mayo Clinic School of Medicine, Jacksonville, Florida, USA.

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February 2021

Primary orofacial granulomatous involvement of lip and gingiva only: A diagnostic challenge.

J Indian Soc Periodontol 2020 Nov-Dec;24(6):575-578. Epub 2020 Nov 14.

Delhi Public School, RK Puram, New Delhi, India.

Wiesenfeld described orofacial granulomatosis (OFG) as a group of noncaseating granulomatous disorders affecting the different parts of the body including oral and maxillofacial region, which can have variable etiology. The involvement of oral and maxillofacial region can be exclusive or primary before the involvement of other organs. OFG is a multifactorial clinicopathologic disorder, and its clinical manifestation mimics the various systemic conditions making its diagnosis tough for a dentist. Read More

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November 2020

Melkersson-Rosenthal syndrome misdiagnosed as recurrent Bell's palsy: a case report and review of literature.

Allergy Asthma Clin Immunol 2021 Jan 9;17(1). Epub 2021 Jan 9.

Department of Neurology, School of Medicine, College of Health Sciences, Addis Ababa University, P.O. Box 41690, Addis Ababa, Ethiopia.

Background: Melkersson-Rosenthal syndrome (MRS) is a rare neuro-mucocutaneous disorder of unknown cause, clinically characterized by a triad of recurrent facial palsy, orofacial swelling, and fissured tongue. It is frequently seen in females in their second and third decades of life. MRS is diagnosed based on clinical features and it is rarely possible to observe all the classical triad symptoms at the same time. Read More

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January 2021

Melkersson-Rosenthal Syndrome: a Case Report of the Classic Triad.

J Dent (Shiraz) 2020 Dec;21(4):335-337

Resident, Dept. of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

Melkersson-Rosenthal syndrome (MRS) is a rare neurological condition that includes a triad of symptoms including recurring facial paralysis, orofacial swelling, and fissured tongue. The diagnosis and treatment of this syndrome is difficult since the classic triad is rarely possible to see in its complete form. The etiology of MRS is unknown, but it is thought to be caused by various factors such as infections, genetic predisposition, immune deficiency, food intolerance, and stress. Read More

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December 2020

Reply to: "The histopathological spectrum of Melkersson-Rosenthal syndrome: Analysis of 47 cases".

J Cutan Pathol 2021 04 18;48(4):604-605. Epub 2020 Dec 18.

Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.

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A case of Melkersson-Rosenthal syndrome with endocrine disorders: Extraordinary efficiency of hydroxychloroquine and mechanism hypothesis.

Eur J Neurol 2021 Mar 14;28(3):928-933. Epub 2020 Dec 14.

State Key Laboratory of Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, China.

Background And Purpose: Melkersson-Rosenthal syndrome (MRS) is a rare neuro-mucocutaneous disease. In addition to the traditional clinical triad, there is also a diversity of clinical signs, and it may be related to other systemic diseases.

Methods: In the present study, we report a case of MRS with endocrine disorders that exhibits extraordinary therapeutic efficiency by using hydroxychloroquine (HCQ), explore whether there is an internal connection between MRS and endocrine disorders, and discuss the mechanism of the therapeutic efficiency of using HCQ. Read More

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Furrowed tongue, fatten lip and facial droop.

Pan Afr Med J 2020;36:325. Epub 2020 Aug 24.

Neurology Section, Department of Medicine, Aga Khan University, Dar es Salaam, Tanzania.

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Diagnosis, Clinical Features, and Management of Patients With Granulomatous Cheilitis.

JAMA Dermatol 2021 01;157(1):112-114

Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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January 2021

Photobiomodulation and Miescher's cheilitis granulomatosa: case report.

Maxillofac Plast Reconstr Surg 2020 Dec 20;42(1):35. Epub 2020 Oct 20.

Department of Biomedical, Surgical and Dental Sciences-Maxillo-Facial and Odontostomatology Unit-Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda, University of Milan, via della Commenda 10, Milan, Italy.

Background: Miescher's cheilitis granulomatosa (MCG) is a rare chronic inflammatory disease and is known as the monosymptomatic clinical form of Melkersson-Rosenthal syndrome (MRS). It is characterised by swelling of one or both lips and more frequently affects the upper lip. Histopathological findings show the presence of numerous inflammatory infiltrates and granuloma formations. Read More

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December 2020

Recurrent peripheral facial palsy as an initial manifestation of Melkersson-Rosenthal syndrome.

Arch Soc Esp Oftalmol (Engl Ed) 2021 Jan 12;96(1):e1. Epub 2020 Sep 12.

Servicio de Oftalmología, Hospital Universitario Reina Sofía de Murcia, Murcia, España.

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January 2021

Think Melkersson-Rosenthal Syndrome: A Fissured Tongue With Facial Paralysis.

Cureus 2020 Jul 30;12(7):e9480. Epub 2020 Jul 30.

Neurology, University of Jordan, Amman, JOR.

Melkersson-Rosenthal syndrome (MRS) was first described and named after E. Melkersson in 1928 and C. Rosenthal in 1931. Read More

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Melkersson-Rosenthal Syndrome Induced by COVID-19.

Am J Emerg Med 2021 Mar 15;41:262.e5-262.e7. Epub 2020 Aug 15.

Department of Dermatology, Bezmialem Vakif University School of Medicine, Istanbul, Turkey.

Melkersson-Rosenthal syndrome is a rare condition characterized by a triad of orofacial edema, facial paralysis, and fissured tongue. Histopathological examination of the disease has demonstrated areas of inflammation involving mast cells. Activated mast cells also play a part in the pathogenesis of COVID-19 infection, as they release cytokines in the lungs. Read More

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Morbihan disease: a case report and differentiation from Melkersson-Rosenthal syndrome.

Dermatol Online J 2020 Jun 15;26(6). Epub 2020 Jun 15.

Department of Dermatology, Tulane University, New Orleans, LA.

We present a 32-year old woman with a 9-year history of upper facial swelling. A workup by the ophthalmology department led to the diagnosis of Melkersson-Rosenthal syndrome. Re-evaluation in our dermatology clinic confirmed a diagnosis of Morbihan disease. Read More

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Recurrent Facial Palsy in a Teenager.

J Pediatr 2021 01 11;228:301-302. Epub 2020 Aug 11.

Department of Paediatrics, Heraklion University Hospital, University of Crete Medical School, Heraklion, Crete, Greece.

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January 2021

Oral lymphangiectasia and gastrointestinal Crohn disease.

J Cutan Pathol 2020 Nov 9;47(11):1080-1084. Epub 2020 Sep 9.

Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Lip edema with non-caseating granulomas or lymphangiectasia pose a clinical and pathological challenge. These findings can be attributed to cheilitis granulomatosa (CG), Melkersson-Rosenthal syndrome (MRS), or Crohn disease (CD) depending on the appropriate clinical context. Lymphangiectasis, in particular, is a common pathological finding in CD due to lymphatic obstruction by granulomas and intralymphatic granulomas. Read More

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November 2020

Cheilitis granulomatosa in a child with juvenile periodontal disease.

J Dermatol 2020 Nov 30;47(11):e397-e398. Epub 2020 Jul 30.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

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November 2020

A severe case of cheilitis granulomatosa: clinical-pathologic findings and management.

Oral Maxillofac Surg 2020 Dec 4;24(4):521-526. Epub 2020 Jul 4.

Department of General Surgery, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi (Meghe), Wardha, Maharashtra, India.

Introduction: Cheilitis granulomatosa is an idiopathic granulomatous disorder which is rare and cosmetically disturbing. It presents with a persistent painless labial swelling which obscure etiology. Diagnosis is mainly based on the histopathological features following biopsy. Read More

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December 2020

Fatal course of clofazimine-induced pulmonary crystal deposition in a patient with Melkersson-Rosenthal syndrome.

Int J Clin Pharmacol Ther 2020 Sep;58(9):518-522

A wide variety of drugs and substances have the potential to damage the respiratory system by different mechanisms. Clofazimine is an anti-leprosy drug that is normally only prescribed for a few years. It has a very long half-life, and crystalline deposition of the drug in various tissues has been documented. Read More

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September 2020

The histopathological spectrum of Melkersson-Rosenthal syndrome: Analysis of 47 cases.

J Cutan Pathol 2020 Nov 6;47(11):1010-1017. Epub 2020 Aug 6.

Department of Pathology, Dental School, University of São Paulo, São Paulo, Brazil.

Background: Melkersson-Rosenthal syndrome (MRS) is a rare disease characterized by the triad of recurrent orofacial edema, relapsing facial paralysis and plicated tongue. Histopathological features of MRS have not been extensively analyzed.

Methods: This study investigated the histopathological aspects of oral lesions from 47 MRS patients. Read More

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November 2020

Panuveitis revealing Melkersson Rosenthal syndrome: a case report.

Tunis Med 2020 Jan;98(1):90-92

Aim: To describe a case of panuveitis revealing Melkersson Rosenthal syndrome (MRS).

Case Report:   A 35-year-old female with a history of bilateral chronic idiopathic panuveitis was referred for work up. On examination, her visual acuity was 3/10 in the right eye and limited to hand motion in the left eye. Read More

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January 2020

Management Strategies of Melkersson-Rosenthal Syndrome: A Review.

Int J Gen Med 2020 26;13:61-65. Epub 2020 Feb 26.

Pediatric Neurology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.

Melkerrson-Rosenthal syndrome is a rare disorder of unknown aetiology and characterized by the triad of oro-facial edema, facial nerve palsy, and furrowing of the tongue. Two or more of the above are essential for making a clinical diagnosis. The mainstay of treatment is corticosteroids. Read More

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February 2020