1,990 results match your criteria Cheilitis Glandularis
Cochrane Database Syst Rev 2018 Nov 24;11:CD009435. Epub 2018 Nov 24.
Emergency Medicine and Evidence Based Medicine, Universidade Federal de São Paulo, Rua Napoleão de Barros, 865, São Paulo, Sao Paulo, Brazil, 04024-002.
Background: Acne vulgaris, a chronic inflammatory disease of the pilosebaceous unit associated with socialisation and mental health problems, may affect more than 80% of teenagers. Isotretinoin is the only drug that targets all primary causal factors of acne; however, it may cause adverse effects.
Objectives: To assess efficacy and safety of oral isotretinoin for acne vulgaris. Read More
Arch Oral Biol 2018 Sep 29;98:99-107. Epub 2018 Sep 29.
Post-Graduate Program in Oral Pathology, Department of Dentistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil. Electronic address:
Objectives: Programmed death ligand-1 (PD-L1) and human leukocyte antigen-G (HLA-G) are considered immune checkpoint molecules that inhibit T-cell effectiveness, contributing to tumor immune escape. This study investigated PD-L1, HLA-G, CD8, and granzyme B (GrB) expression at different stages of lip carcinogenesis.
Design And Results: Forty cases of lip squamous cell carcinoma (LSCC), 55 actinic cheilitis (AC), and 10 healthy lip mucosa (HLM) were submitted to immunohistochemistry. Read More
Acta Clin Croat 2018 Jun;57(2):342-351
Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
Although cheilitis as a term describing lip inflammation has been identified and recognized for a long time, until now there have been no clear recommendations for its work-up and classification. The disease may appear as an isolated condition or as part of certain systemic diseases/conditions (such as anemia due to vitamin B12 or iron deficiency) or local infections (e.g. Read More
Open Vet J 2018 30;8(2):224-228. Epub 2018 Jun 30.
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium.
An 11-year-old, male North African spiny-tailed lizard () was presented with hyperkeratotic cheilitis. Based on clinical examination, histology and microbiological testing, was identified as the causative agent of the dermal disorder. Moreover, an abundant culture of was obtained following sampling of the oral cavity. Read More
Pan Afr Med J 2018 20;30:147. Epub 2018 Jun 20.
Service d'Hépato-gastroentérologie, Faculté de Médecine et de Pharmacie de Fès, Université Sidi Mohammed Ben Abdellah, Fès, Maroc.
Many disorders of the digestive tract cause cutaneous manifestations that may be an indication of an underlying condition; hence dermatologist plays a key role in recommending that the patient see a gastroenterologist. Conversely, gastroenterologist often sees patients with mucocutaneous lesions suggesting possible association with well-known digestive disorders. Chronic inflammatory bowel diseases are the typical example of this essential collaboration between the two specialities. Read More
Rev Med Brux 2018;39(4):317-321
Service de Dentisterie - Chirurgie orale et maxillo-faciale - Orthodontie - Stomatologie, Hôpital Erasme, ULB.
Oral allergies to dental materials are a growing problem and remain poorly diagnosed by health professionals. The complaints of patients with oral allergy are various and include sensations of burning or stinging of the oral mucosa, sensations of dryness of the oral cavity, or general symptoms such as headache, dyspepsia, asthenia, arthralgia, and myalgia. Signs suggestive of oral allergy include erythema, edema, purpuric patches on the palate, ulcerations of the oral mucosa (canker sore), gingivitis, glossitis mimicking geographic tongue, angular cheilitis, peri-oral eczema or the presence of lichenoid reactions of the oral mucosa. Read More
Contact Dermatitis 2019 Jan 11;80(1):65-67. Epub 2018 Oct 11.
Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida.
Pediatr Dermatol 2018 Nov 11;35(6):796-799. Epub 2018 Oct 11.
Division of Pediatric Neurology, Department of Pediatrics, Dayanand Medical College & Hospital, Ludhiana, Punjab, India.
Background/objectives: Vitamin B deficiency in infants is uncommonly reported from developed countries and generally lacks dermatologic manifestations. On the contrary, infantile vitamin B deficiency is common in India and cutaneous manifestations are a constant feature, although often overshadowed by neurologic and hematological manifestations. The aim of this study was to describe the skin changes of vitamin B deficiency in infants. Read More
J Dtsch Dermatol Ges 2018 Oct;16(10):1269-1273
Abteilung für Dermatologie, Venerologie und Allergologie Universitätsklinikum Essen.
BMC Cancer 2018 Oct 5;18(1):957. Epub 2018 Oct 5.
Department of Pharmacy, Shiga University of Medical Science Hospital, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan.
Background: Chemotherapy-induced oral mucositis impairs the quality of life. The difference in severity of oral mucositis between different anti-epidermal growth factor receptor (EGFR) antibodies combined with cytotoxic drugs in colorectal cancer is unclear. The aim of this study was to investigate the differences in oral mucositis between panitumumab (Pmab) and cetuximab (Cmab) combined with 5-fluorouracil (5-FU). Read More
Clin Exp Dermatol 2018 Sep 21. Epub 2018 Sep 21.
Department of Dermatology, Hospital General de Baza, Avenida Murcia S/N, CP 18800, Granada, Spain.
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Aug 18. Epub 2018 Aug 18.
Department of Dermatovenereology, University Hospital Center Sestre milosrdnice, Zagreb, Croatia; School of Dental Medicine, University of Zagreb, Zagreb, Croatia.
Objective: The aim of this study was to examine potential allergic reactions to different materials in oral and perioral diseases.
Study Design: The study included 230 consenting subjects in total-180 patients with oral and perioral diseases (30 patients each in the following groups: angioedema, oral lichenoid reactions [OLRs], burning mouth syndrome [BMS], gingivostomatitis, cheilitis, and perioral dermatitis) and 50 healthy controls. Comprehensive diagnostic workups were performed prior to patch testing with standard series allergens and with specific dental materials and skin prick testing (SPT) for food, preservatives and additives, and inhalants. Read More
J Dtsch Dermatol Ges 2018 Oct 13;16(10):1269-1272. Epub 2018 Sep 13.
Department of Dermatology, Venereology and Allergology, Essen University Medical Center, Essen, Germany.
Dermatol Online J 2018 Aug 23;24(6). Epub 2018 Aug 23.
Pediatrics, Johns Hopkins Children's Center, Baltimore, Maryland.
We discuss imiquimod associated with non-application site mucosal reactions and two of our own clinical cases. In one of our patients, erosive cheilitis developed in a young boy after using topical imiquimod 5% cream for 5 nights weekly on bilateral cheeks, chin, and near vermillion border for molluscum contagiosum. The case is discussed with concerns for imiquimod use in molluscum contagiosum when used near mucosal surfaces. Read More
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Jul;43(7):779-783
Department of Oral Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
Objective: To analyze the incidence and distribution of oral mucosal diseases in Hunan Province and provide reference for prevention and treatment. Methods: The clinical data for all patients, who were treated in Xiangya Hospital of Central South University from April 2013 to March 2017, were collected. After screening, weighing and classifying, sex and age distribution for the disease was analyzed. Read More
J Am Dent Assoc 2018 Aug 10. Epub 2018 Aug 10.
Cleve Clin J Med 2018 Aug;85(8):581-582
Internal Medicine Program Director, Department of Medicine, King Abdullah University Hospital, Jordan.
Acta Derm Venereol 2018 Nov;98(10):970-974
Department of Dermatology, Hospital da Barbanza, University Hospital of Santiago de Compostela, ES-15706 Santiago de Compostela, Spain.
Actinic cheilitis is thought to be a premalignant lesion or a superficial squamous cell carcinoma. The prevalence of actinic cheilitis in Europe is unknown. The aim of this study was to determine the prevalence of actinic cheilitis in the Galicia region (north-west Spain). Read More
Photodermatol Photoimmunol Photomed 2018 Jul 31. Epub 2018 Jul 31.
Photodermatosis Clinic and Laser Unit, Department of Dermatology, Rabin Medical Center, Petah Tikva, Israel.
Background: Actinic cheilitis (AC) is a common, chronic premalignant condition resulting from protracted sun exposure affecting the vermilion border of the lower lip. Treatment of AC aims at terminating the progression to squamous cell carcinoma by obliterating the primary lesion, and includes ablative methods; nonablative modalities such as cryotherapy, electrodessication, chemical peeling, topical imiquimod and 5-fluorouracil; and photodynamic therapy (PDT). Daylight-activated PDT, in which natural daylight serves as the light source, showed promising results in the treatment of actinic keratoses with substantially less pain than conventional PDT. Read More
Contact Dermatitis 2018 Nov 17;79(5):318-319. Epub 2018 Jul 17.
Department of Dermatology, Contact Allergy Unit, University Hospitals K.U. Leuven, Leuven, Belgium.
Dermatol Res Pract 2018 29;2018:6974045. Epub 2018 May 29.
Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Acne vulgaris is an inflammatory disease of pilosebaceous units which may cause permanent dyspigmentation and/or scars if not treated. Isotretinoin is recommended in the treatment of recalcitrant or severe acne, but it is associated with common adverse effects that frequently result in patients incompliance and discontinuation of the drug. The present study was designed to assess the efficacy of oral omega-3 in decreasing the adverse effects of isotretinoin. Read More
Clin Case Rep 2018 Jul 28;6(7):1383-1384. Epub 2018 May 28.
Teaching Hospital-Jaffna Jaffna Sri Lanka.
The Mucocutaneous Leishmaniasis (MCL) involving lip is extremely uncommon. A clinical diagnosis of Leishmaniasis of the lips is often challenging to the treating clinician and may result in delayed diagnosis as this case illustrates. MCL should be considered in the differential diagnosis of lip lesions in a Leishmania endemic area. Read More
Cureus 2018 May 2;10(5):e2565. Epub 2018 May 2.
Department of Oral and Maxillofacial Pathology, San Antonio Military Medical Center.
Factitial cheilitis is a rare diagnosis of exclusion that occurs most frequently in young women with a history of anxiety disorders and recent psychosocial stressors. It presents as continuous keratinaceous build-up, crusting, and desquamation of the lips, consistent with exfoliative cheilitis. Affected areas can progress to superinfection with Staphylococcus aureus or Candida albicans. Read More
Rom J Morphol Embryol 2018 ;59(1):243-248
Department of Cell and Molecular Biology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania;
Premalignant oral lesions are among the most important risk factors for the development of oral squamocellular carcinoma. Recent population studies indicate a significant rise in the prevalence of leukoplakia, erythroplakia/erythroleukoplakia, actinic cheilitis, submucous fibrosis and erosive lichen planus. Since standard histopathological examination has numerous limitations regarding the accurate appreciation of potential malignant transformation, the present study aims to aid these evaluations using the transmission electron microscopy (TEM) technique, which emphasizes ultrastructural changes pertaining to this pathology. Read More
J Oral Pathol Med 2018 Sep 12;47(8):788-795. Epub 2018 Jul 12.
Postgraduate Program in Dentistry, Dental School, State University of Paraíba, Campina Grande, PB, Brazil.
Background: Actinic cheilitis (AC) is a potentially malignant disorder that can progress to squamous cell carcinoma (SCC), but this process is not fully understood. This study evaluated the immunoexpression of glucocorticoid receptor alpha (GRα) isoform and apoptotic proteins (Bcl-2 and Bax) in AC and lower lip SCC (LLSCC).
Methods: Twenty-two AC and 44 LLSCCs (22 with regional nodal metastasis and 22 without metastasis) were selected. Read More
Med Oral Patol Oral Cir Bucal 2018 Jul 1;23(4):e391-e400. Epub 2018 Jul 1.
Departamento de Especialidades, Clinicas Odontologicas, Facultad de Odontologia, Universidad Complutense de Madrid, Plaza Ramon y Cajal s/n, 28040 Madrid, Spain,
Background: Sjogren's syndrome (SS) is an autoimmune disease related to two common symptoms: dry mouth and eyes. Although, xerostomia and hyposialia have been frequently reported in these patients, not many studies have evaluated other oral manifestations. The aim of this systematic review was to investigate prevalence rates of oral lesions (OL) in SS patients and to compare it to a control group (CG), when available. Read More
J Clin Gastroenterol 2018 Jun 16. Epub 2018 Jun 16.
Background: Up to 50% of pediatric patients with Crohn's disease (CD) report oral manifestations, but less is known about their oral health when they become adults.
Goals: Our aim was to provide detailed descriptions of the presence of oral and otorhinolaryngological manifestations in patients with pediatric onset CD once they reached adulthood, to look for predisposing factors and to compare the findings to matched controls.
Study: Adult patients diagnosed with CD in childhood at the Children's Hospital, University of Helsinki, Finland, after 2000 were invited for a follow-up appointment in 2016 and 24 were examined by a dentist and otorhinolaryngologist. Read More
Oral Dis 2018 Jun 16. Epub 2018 Jun 16.
Dental Materials and Prosthodontics, São Paulo State Univeristy (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil.
Objective: The aim of this systematic review was to compare outcomes between surgical and non-surgical treatment of actinic cheilitis (AC).
Materials And Methods: A systematic review and meta-analysis based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses guideline was performed. A search of PubMed/MEDLINE, Web of Science, and Cochrane Library databases was conducted. Read More
Dermatol Online J 2018 Apr 15;24(4). Epub 2018 Apr 15.
Department of Dermatology, University of California San Diego, La Jolla, California.
5-fluorouracil, a fluoropyrimidine antineoplastic drug, is used to topically treat actinic keratoses. Local skin reactions to the medication are common and anticipated. However, severe adverse events from topical 5-fluorouracil are rare and unexpected. Read More
Braz Dent J 2018 Mar-Apr;29(2):214-221
Oral Pathology, USP - Universidade de São Paulo, São Paulo, SP, Brazil.
The objective of the present study was to determine the prevalence of actinic cheilitis among extractive mining workers and factors associated with the condition, especially the relationship between clinical appearance and the length of occupational exposure to sunlight. A cross-sectional study was performed in Dona Inês, Paraíba, Brazil between 2014 and 2015. A clinical examination, clinical photography and a questionnaire were applied to 201 extractive mining workers. Read More
Int J Dent 2018 17;2018:4030134. Epub 2018 May 17.
Faculty of Pharmacy, Lebanese University, Beirut, Lebanon.
Background: Prevalence and distribution of oral mucosal lesions in a sample of Lebanese population attending the School of Dentistry of Lebanese University is necessary to evaluate their oral health situation.
Objectives: The aim of the present study was to determine the prevalence and distribution of oral mucosal lesions of patients attending the School of Dentistry.
Methods: A descriptive study was carried out by retrospectively examining a total of 231 medical and clinical examination record files of patients, attending the School of Dentistry Lebanese University for multidisciplinary dental treatments. Read More
Ann Dermatol Venereol 2018 Aug - Sep;145(8-9):492-499. Epub 2018 Jun 6.
Service de pathologie, hôpital Cochin, 27, rue du faubourg Saint-Jacques, 75014 Paris, France.
Background: Miescher's cheilitis, whether occurring alone or as part of Melkersson-Rosenthal syndrome, is a rare type of granulomatous inflammation of unknown cause with an even rarer genital equivalent. Herein, we describe a case of the latter condition developing over a 12-year period.
Patients And Methods: A 27-year-old woman presented episodes of unilateral vulvar oedema, which initially regressed but resulted over time in permanent vulvar and perineal tumefaction. Read More
J Investig Clin Dent 2018 Nov 4;9(4):e12343. Epub 2018 Jun 4.
College of Medicine and Dentistry, James Cook University, Cairns, Queensland, Australia.
The aim of the present systematic review was to determine the malignant transformation rate of actinic cheilitis (AC). A comprehensive literature search was conducted using Medline/PubMed, Cumulative Index of Nursing and Allied Health Literature, Scopus, OvidSP, and Google Scholar. The inclusion criteria comprised of observational human studies involving the malignant transformation of AC and publications in English. Read More
Int J Rheumatol 2018 10;2018:6052326. Epub 2018 Apr 10.
Research Department, Weill Cornell Medicine-Qatar, P.O. Box 24144, Doha, Qatar.
Objective: The purpose of this pilot study was to assess the prevalence of oral manifestations among systemic lupus erythematosus (SLE) patients in Qatar, in order to warrant future studies that would investigate each one of these manifestations with detail and further scrutiny.
Methods: Study procedures took place between November 2014 and April 2016. All patients visiting the outpatient rheumatology clinics at Hamad General Hospital, Doha, Qatar, were asked to join. Read More
Dermatol Surg 2018 Sep;44(9):1201-1208
All authors are affiliated with the Department of Dermatology, Second Affiliated Hospital of Xi'an Jiaotong University, Shanxi, China.
Background: Nonablative fractional laser (NAFL) has been shown to improve the appearance of inflammatory acne and acne scars. Isotretinoin is effective for the treatment of moderate-to-severe cases of recalcitrant acne. However, the recommended dose of isotretinoin can have profound effects. Read More
Eur Arch Otorhinolaryngol 2018 Jul 19;275(7):1877-1883. Epub 2018 May 19.
Department of Oral and Maxillofacial Pathology, School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227, São Paulo, SP, 05508-000, Brazil.
Purpose: The aim of this work was to evaluate the expression of the cancer stem cell (CSC) markers CD44, ALDH1 and p75NTR in the ultraviolet-induced lesions actinic cheilitis (AC) and lip squamous cell carcinoma (LSCC), and to correlate it with p53 expression.
Methods: Immunohistochemistry was performed in 4 cases of normal lip (NL), 43 of AC and 20 of LSCC.
Results: All cases were positive for CD44, showing a membranous staining without differences between the groups. Read More
Curr Pediatr Rev 2018 ;14(3):196-203
Department of Pediatrics, Hospital Ostallgau-Kaufbeuren, Kaufbeuren, Germany.
Background And Objective: Melkersson Rosenthal syndrome (MRS) is a rare disorder of unknown etiology and comprises the triad: orofacial edema, recurrent facial paralysis and lingua plicata. In the current literature confusing heterogeneity exists, mixing together the historically grown terms cheilitis granulomatosa or granulomatous cheilitis, Melkersson Rosenthal syndrome and the umbrella term Orofacial Granulomatosis (OFG).
Methods: We provide a systematic review comprising all three disease entities of orofacial granulomatosis using the computerized database "Pubmed Medline" entering the keywords "orofacial granulomatosis" (141 references), "Melkersson-Rosenthal syndrome" (207 references), "granulomatous cheilitis" or "cheilitis granulomatosa" (102 references) back to 1956. Read More
Oral Dis 2018 Oct 28;24(7):1209-1216. Epub 2018 Jun 28.
Dentistry Graduate Program, Federal University of Santa Catarina, Florianopolis, Brazil.
Cancer stem cell (CSC) proteins have been observed in several lesions and are associated with tumor beginning, evolution, and resistance to treatment.
Objectives: To investigate the presence of NANOG, NESTIN, and β-tubulin in lip squamous cell carcinoma (LSCC), actinic cheilitis (AC), and normal epithelium (NE).
Materials And Methods: Thirty cases of LSCC, thirty cases of AC (both analyzed according to the WHO classification and AC according to the binary classification), and twenty cases of NE were submitted to an immunohistochemical study. Read More
Clin Rev Allergy Immunol 2018 May 12. Epub 2018 May 12.
Division of Gastroenterology and Hepatology, Penn State Milton S Hershey Medical Center, 500 University Dr, Hershey, PA, 17033, USA.
Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammatory condition primarily involving the gastrointestinal tract. It includes Crohn's disease (CD), ulcerative colitis (UC), and a less common phenotype-indeterminate colitis. It is thought to result from a complex interplay of environmental, microbial, and host factors including genetic factors, although the exact mechanism is not known. Read More
Am J Clin Dermatol 2018 Oct;19(5):647-656
Dermatology, Bern, Switzerland.
Topical photodynamic therapy (PDT) using daylight is effective in the treatment of actinic keratoses (AKs), offering the potential for treatment of large fields such as full face and balding scalp, but with minimal therapy-associated pain. Comparison with conventional PDT indicates similar efficacy for thin and moderate-thickness AKs, but with significantly less discomfort/pain, driving a patient preference for daylight-mediated PDT (DL-PDT) compared with conventional PDT using high-intensity office/hospital-based light sources. Treatment protocol involves the application of a photosensitizing agent without occlusion and subsequent exposure to ambient daylight within 30 min, with patients exposed to daylight for 1. Read More
Contact Dermatitis 2018 Sep 11;79(3):176-178. Epub 2018 May 11.
Department of Dermatology, Hospital General Universitario Gregorio Maranon, Madrid, Spain.
Case Rep Dent 2018 18;2018:9169208. Epub 2018 Mar 18.
Division of Oral Medicine Clinic, Department of Stomatology, School of Dentistry, University of Sao Paulo, Sao Paulo, SP, Brazil.
Cheilitis glandularis (CG) is an inflammatory condition of unknown cause that predominantly affects the minor salivary glands of the lips. Although a diagnosis of CG is not difficult, its treatment is a challenge. This article highlights the clinical presentation of the disease together with a case of successful management of this disease using a combination of a steroid injection followed by a topical immunosuppressor. Read More
J Cutan Pathol 2018 May 8. Epub 2018 May 8.
Department of Oral and Maxillofacial Pathology, School of Dentistry, University of São Paulo - USP, São Paulo, Brazil.
Background: We analyzed the different grades of dysplasia in the epithelium adjacent to lip squamous cell carcinoma (LSCC), as a parallel to actinic cheilitis (AC) that suffered malignant transformation.
Methods: Forty samples of epithelium adjacent to LSCC were histologically graded according to the World Health Organization (WHO) and the binary systems. The expression of mutated p53 was evaluated through immunohistochemistry. Read More
J Oral Pathol Med 2018 Aug 6;47(7):633-640. Epub 2018 Jun 6.
Department of Pathology, Health Sciences Center, Federal University of Santa Catarina, Florianópolis, Brazil.
Oral potentially malignant disorders (OPMD) are chronic conditions, which have a higher risk of transformation to oral squamous cell carcinoma. The aim of this systematic review and meta-analysis was to answer the question: "What is the prevalence of oral potentially malignant disorders among adults?" Studies reporting the prevalence of these conditions (leukoplakia, erythroplakia, oral submucous fibrosis [OSMF], and actinic cheilitis) were selected, only studies in which a clinical assessment and histopathological confirmation were performed were included. Of the 5513 studies, 22 met the inclusion criteria for qualitative and quantitative analyses. Read More
Environ Sci Pollut Res Int 2018 May 8. Epub 2018 May 8.
Department of Oral Pathology, School of Dentistry, Federal University of Bahia, Av. Araújo Pinho, 62. Canela, Salvador, Bahia, 40110-150, Brazil.
The aim of this cross-sectional study was to evaluate the prevalence of oral mucosal lesions (OMLs) and their association with crack/cocaine addiction in men. Clinical oral examination was performed in 161 adult male patients at the School of Dentistry of the Federal University of Bahia, Brazil. Crack/cocaine addiction was determined from the medical records, and all drug-addicted individuals used both crack and cocaine. Read More
Gerodontology 2018 Jun;35(2):151-154
Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Odontology, University of Santiago de Compostela, Santiago de Compostela, Spain.
Objective: To report conservative treatment based on the use of dermal fillers for a case of recurrent angular cheilitis.
Case Report: An 80-year-old patient with a history of recurrent angular cheilitis that was not resolved with a conventional approach sought treatment. Complete remission of the pathology was achieved with the injection of hyaluronic acid fillers. Read More
J Contemp Dent Pract 2018 Apr 1;19(4):384-388. Epub 2018 Apr 1.
Department of Dentistry, University of Passo Fundo, Passo Fundo, Rio Grande do Sul, Brazil, Brazil, Phone: +555433168402, e-mail:
Actinic cheilitis (AC) is a lesion potentially malignant that affects the lips after prolonged exposure to solar ultraviolet (UV) radiation. The present study aimed to assess and describe the proliferative cell activity, using silver-stained nucleolar organizer region (AgNOR) quantification proteins, and to investigate the potential associations between AgNORs and the clinical aspects of AC lesions. Cases diagnosed with AC were selected and reviewed from Center of Histopathological Diagnosis of the Institute of Biological Sciences, Passo Fundo University, Brazil. Read More
Mol Clin Oncol 2018 May 26;8(5):640-646. Epub 2018 Mar 26.
Department of Pathology, 'Carol Davila' University of Medicine and Pharmacy, Bucharest 050474, Romania.
An early diagnosis is of overwhelming importance for the management and prognosis of mucocutaneous cancer. Actinic cheilitis (AC), defined by the clonal expansion of genomically unstable keratinocytes, is the most common potentially malignant lesion affecting the lips. Squamous cell carcinoma (SCC) is the most frequent oral malignancy, and there is strong evidence that the majority of the SCCs of the lip originate from AC. Read More