246,691 results match your criteria Channels Austin Tex.[Journal]


Functional and behavioral signatures of Kv7 activator drug subtypes.

Epilepsia 2020 Jul 11. Epub 2020 Jul 11.

Department of Pharmacology, Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.

Objective: Voltage-gated potassium channels of the KCNQ (Kv7) family are targeted by a variety of activator compounds with therapeutic potential for treatment of epilepsy. Exploration of this drug class has revealed a variety of effective compounds with diverse mechanisms. In this study, we aimed to clarify functional criteria for categorization of Kv7 activator compounds, and to compare the effects of prototypical drugs in a zebrafish larvae model. Read More

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http://dx.doi.org/10.1111/epi.16592DOI Listing

Enhanced electrochemical decontamination and water permeation of titanium suboxide reactive electrochemical membrane based on sonoelectrochemistry.

Ultrason Sonochem 2020 Jul 4;69:105248. Epub 2020 Jul 4.

State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin 150090, China.

Reactive electrochemical membrane (REM) allows electrochemical oxidation (EO) water purification under flow-through operation, which improves mass transfer on the anode surface significantly. However, O evolution reaction (OER) may cause oxygen bubbles to be trapped in small-sized confined flow channels, and thus degrade long-term filterability and treatability of REM. In this study, ultrasound (ultrasonic vibrator, 28 kHz, 180 W) was applied to EO system (i. Read More

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http://dx.doi.org/10.1016/j.ultsonch.2020.105248DOI Listing

Amelioration of diabetes-induced cognitive impairment by Transient Receptor Potential Vanilloid 2 (TRPV2) channel inhibitor: Behavioral and mechanistic study.

Neurochem Int 2020 Jul 8:104783. Epub 2020 Jul 8.

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), S. A. S. Nagar, Punjab, India. Electronic address:

Transient receptor potential (TRP) channels are Ca permeable non-selective cation channels which play a pivotal role in diabetes and diabetic complications. Among diabetic complications, diabetes-induced cognitive impairment is a major CNS complication. The role of several TRP channels has been investigated extensively for their diverse Ca regulating mechanism, and recently their role has been postulated in the progression of neurodegenerative disorders. Read More

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http://dx.doi.org/10.1016/j.neuint.2020.104783DOI Listing

The Regulatory and Enzymatic Functions of CRMPs in Neuritogenesis, Synaptic Plasticity, and Gene Transcription.

Authors:
Sheng Tao Hou

Neurochem Int 2020 Jul 8:104795. Epub 2020 Jul 8.

Brain Research Centre and Department of Biology, Southern University of Science and Technology, 1088 Xueyuan Blvd, Nanshan District, Shenzhen, Guangdong Province, PR China, 518055; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. Electronic address:

Collapsin response mediator proteins (CRMPs) are ubiquitously expressed in neurons from worms to humans. A cardinal feature of CRMPs is to mediate growth cone collapse in response to Semaphorin-3A signaling through interactions with cytoskeletal proteins. These are critical regulatory roles that CRMPs play during neuritogenesis and neural network formation. Read More

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http://dx.doi.org/10.1016/j.neuint.2020.104795DOI Listing

Role of TRPV1/TRPV3 channels in olanzapine-induced metabolic alteration: Possible involvement in hypothalamic energy-sensing, appetite regulation, inflammation and mesolimbic pathway.

Toxicol Appl Pharmacol 2020 Jul 8:115124. Epub 2020 Jul 8.

Pharmacology Research Lab, University Institute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh 160014, India. Electronic address:

Atypical antipsychotics (AAPs) have the tendency of inducing severe metabolic alterations like obesity, diabetes mellitus, insulin resistance, dyslipidemia and cardiovascular complications. These alterations have been attributed to altered hypothalamic appetite regulation, energy sensing, insulin/leptin signaling, inflammatory reactions and active reward anticipation. Line of evidence suggests that transient receptor potential vanilloid type 1 and 3 (TRPV1 and TRPV3) channels are emerging targets in treatment of obesity, diabetes mellitus and could modulate feed intake. Read More

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http://dx.doi.org/10.1016/j.taap.2020.115124DOI Listing

The Dual PDZ Domain from Postsynaptic Density Protein 95 Forms a Scaffold with Peptide Ligand.

Biophys J 2020 Jun 26. Epub 2020 Jun 26.

School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom. Electronic address:

PSD-95 is a member of the membrane-associated guanylate kinase class of proteins that forms scaffolding interactions with partner proteins, including ion and receptor channels. PSD-95 is directly implicated in modulating the electrical responses of excitable cells. The first two PSD-95/disks large/zona occludens (PDZ) domains of PSD-95 have been shown to be the key component in the formation of channel clusters. Read More

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http://dx.doi.org/10.1016/j.bpj.2020.06.018DOI Listing

Physiopathological roles of vesicular nucleotide transporter (VNUT), an essential component for vesicular ATP release.

Biochim Biophys Acta Biomembr 2020 Jul 8:183408. Epub 2020 Jul 8.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan.

Vesicular nucleotide transporter (VNUT) is the last identified member of the SLC17 organic anion transporter family, which plays a central role in vesicular storage in ATP-secreting cells. The discovery of VNUT demonstrated that, despite having been neglected for a long time, vesicular ATP release represents a major pathway for purinergic chemical transmission, which had been mainly attributed to ATP permeation channels. This article summarizes recent advances in our understanding of the mechanism of VNUT and its physiopathological roles as well as the development of inhibitors. Read More

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http://dx.doi.org/10.1016/j.bbamem.2020.183408DOI Listing

Sociocultural learning in emergency medicine: a holistic examination of competence.

Diagnosis (Berl) 2020 Jul 13. Epub 2020 Jul 13.

Institute for Social Innovation, Fielding Graduate University, 2020 De la Vina Street, Santa Barbara, CA 93105-3814, USA.

Objectives In the medical community of practice, the resident is situated in systems of professional and cultural activities. How diagnostic competence manifests in their sociocultural context is examined through situativity and systems theories. A holistic model is proposed that could examine diagnostic competence across micro (individual), meso (activity), and macro (cultural) systems. Read More

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http://dx.doi.org/10.1515/dx-2020-0001DOI Listing

Comparison of Bromhexine and its Active Metabolite - Ambroxol as Potential Analgesics Reducing Oxaliplatin-Induced Neuropathic Pain - Pharmacodynamic and Molecular Docking Studies.

Curr Drug Metab 2020 Jul 11. Epub 2020 Jul 11.

Department of Pharmacodynamics, Chair of Pharmacodynamics, Jagiellonian University Medical College, 9 Medyczna St., 30-688 Krakow. Poland.

Background: Painful peripheral neuropathy is a dose-limiting adverse effect of the antitumor drug oxaliplatin. The main symptoms of neuropathy: tactile allodynia and cold hyperalgesia, appear in more than 80% of patients on oxaliplatin therapy and are due to the overexpression of neuronal sodium channels (Navs) and neuroinflammation.

Objective: This study assessed antiallodynic and antihyperalgesic properties of two repurposed drugs with antiinflammatory and Nav-blocking properties (bromhexine and its pharmacologically active metabolite - ambroxol) in a mouse model of neuropathic pain induced by oxaliplatin. Read More

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http://dx.doi.org/10.2174/1389200221666200711155632DOI Listing

All-Optical Miniaturized Co-culture Assay of Voltage-Gated Ca Channels.

Methods Mol Biol 2020 ;2173:247-260

Australian Regenerative Medicine Institute (ARMI), Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, Australia.

Light-activated proteins enable the reversible and spatiotemporal control of cellular events in optogenetics. Optogenetics is also rapidly expanding into the field of drug discovery where it provides cost-effective and noninvasive approaches for cell manipulation in high-throughput screens. Here, we present a prototypical cell-based assay that applies Channelrhodopsin2 (ChR2) to recapitulate physiological membrane potential changes and test for voltage-gated ion channel (VGIC) blockade. Read More

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http://dx.doi.org/10.1007/978-1-0716-0755-8_17DOI Listing
January 2020

Relaxing Effect of Hydrogen Sulfide on Isolated Bovine Mesenteric Lymph Nodes.

Authors:
G I Lobov

Bull Exp Biol Med 2020 Jul 10. Epub 2020 Jul 10.

Laboratory of Physiology of Cardiovascular and Lymphatic Systems, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.

We studied the effects and mechanisms of action of NaHS, an HS donor, on isolated phenylephrine-precontracted bovine mesenteric lymph nodes. NaHS induced concentration-dependent relaxation of lymph nodes. Removal of the endothelium reduced, but did not abolish the relaxing effect of NaHS. Read More

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http://dx.doi.org/10.1007/s10517-020-04848-zDOI Listing

Nodes of Ranvier during development and repair in the CNS.

Nat Rev Neurol 2020 Jul 10. Epub 2020 Jul 10.

Sorbonne University, Inserm, CNRS, ICM-Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

Saltatory conduction of action potentials along myelinated axons depends on the nodes of Ranvier - small unmyelinated axonal domains where voltage-gated sodium channels are concentrated. Our knowledge of the complex molecular composition of these axonal domains continues to accumulate, although the mechanisms of nodal assembly, which have been elucidated in the PNS, remain only partially understood in the CNS. Besides the key role of the nodes in accelerating conduction, nodal variations are thought to allow the fine tuning of axonal conduction speed to meet information processing needs. Read More

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http://dx.doi.org/10.1038/s41582-020-0375-xDOI Listing

All-printed nanomembrane wireless bioelectronics using a biocompatible solderable graphene for multimodal human-machine interfaces.

Nat Commun 2020 Jul 10;11(1):3450. Epub 2020 Jul 10.

George W. Woodruff School of Mechanical Engineering, Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA, 30332, USA.

Recent advances in nanomaterials and nano-microfabrication have enabled the development of flexible wearable electronics. However, existing manufacturing methods still rely on a multi-step, error-prone complex process that requires a costly cleanroom facility. Here, we report a new class of additive nanomanufacturing of functional materials that enables a wireless, multilayered, seamlessly interconnected, and flexible hybrid electronic system. Read More

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http://dx.doi.org/10.1038/s41467-020-17288-0DOI Listing

Development of Alzheimer's Disease Progressively Alters Sex-Dependent KCa and Sex-Independent KIR Channel Function in Cerebrovascular Endothelium.

J Alzheimers Dis 2020 Jul 7. Epub 2020 Jul 7.

Basic Sciences, Loma Linda University, Loma Linda, CA, USA.

Background: Development of Alzheimer's disease (AD) pathology is associated with impaired blood flow delivery of oxygen and nutrients throughout the brain. Cerebrovascular endothelium regulates vasoreactivity of blood vessel networks for optimal cerebral blood flow.

Objective: We tested the hypothesis that cerebrovascular endothelial Gq-protein-coupled receptor (GPCR; purinergic and muscarinic) and K+ channel [Ca2+-activated (KCa2. Read More

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http://dx.doi.org/10.3233/JAD-200085DOI Listing

Agonists of orally expressed TRP channels stimulate salivary secretion and modify the salivary proteome.

Mol Cell Proteomics 2020 Jul 10. Epub 2020 Jul 10.

King's College London.

Natural compounds that can stimulate salivary secretion are of interest in developing treatments for xerostomia, the perception of a dry mouth, that affects between 10 and 30% of the adult and elderly population.  Chemesthetic transient receptor potential (TRP) channels are expressed in the surface of the oral mucosa. The TRPV1 agonists capsaicin and piperine have been shown to increase salivary flow when introduced into the oral cavity but the sialogogic properties of other TRP channel agonists have not been investigated. Read More

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http://dx.doi.org/10.1074/mcp.RA120.002174DOI Listing

Highly Active Gas Phase Organometallic Catalysis Supported Within Metal-organic Framework Pores.

J Am Chem Soc 2020 Jul 10. Epub 2020 Jul 10.

Metal-organic Frameworks (MOFs) can act as a platform for the heterogenization of molecular catalysts, providing im-proved stability, allowing easy catalyst recovery and a route towards structural elucidation of the active catalyst. We have developed a MOF, 1, possessing vacant N,N-chelating sites which are accessible via the porous channels that penetrate the structure. In the present work, cationic Rhodium(I) norbornadiene (NBD) and bis(ethylene) complexes paired with both non-coordinating and coordinating anions have been incorporated into the N,N-chelation sites of 1 via post-synthetic metalation and facile anion exchange. Read More

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http://dx.doi.org/10.1021/jacs.0c05286DOI Listing

Engineering as a chassis for synthesis of five aromatic-derived natural products and chemicals.

ACS Synth Biol 2020 Jul 10. Epub 2020 Jul 10.

is a novel microbial chassis to upgrade renewable low-cost carbon feedstocks to high-value commodity chemicals and natural products. In this work, we systematically characterized and removed the rate-limiting steps of the shikimate pathway and achieved synthesis of five aromatic chemicals in . We determined that eliminating amino acids formation and engineering feedback-insensitive DAHP synthases are critical steps to mitigate precursor competition and relieve the feedback regulation of shikimate pathway. Read More

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http://dx.doi.org/10.1021/acssynbio.0c00185DOI Listing

Chiral and SHG-Active Metal-Organic Frameworks Formed in Solution and on Surfaces: Uniformity, Morphology Control, Oriented Growth, and Post-assembly Functionalization.

J Am Chem Soc 2020 Jul 10. Epub 2020 Jul 10.

We demonstrate the formation of uniform and oriented metal-organic frameworks using a combination of anion-effects and surface-chemistry. Subtle but significant morphological changes result from the nature of the coordinative counter-anion of the following metal salts: NiX with (X = Br, Cl, NO, and OAc). Crystals could be obtained in solution or by template surface growth. Read More

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http://dx.doi.org/10.1021/jacs.0c05384DOI Listing

Controlled Drug Release by the Pore Structure in Polydimethylsiloxane Transdermal Patches.

Polymers (Basel) 2020 Jul 8;12(7). Epub 2020 Jul 8.

Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical University of Gdansk, Hallera 107 Street, 80-210 Gdansk, Poland.

The use of polydimethylsiloxanes (PDMS) as a drug carrier in transdermal adhesive patches is limited and there is insufficient data on the polymer structure and diffusivity, especially when additives modify the matrix. PDMS films with liquid additives (10% /): silicone oil (SO), polyoxyethylene glycol (PEG) or propylene glycol (PG) were prepared and indomethacin (IND; 5% /) was incorporated as a model active substance. The microstructure of the PDMS matrix and its permeability to water was investigated and correlated to the kinetics of the in-vitro IND release from the film. Read More

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http://dx.doi.org/10.3390/polym12071520DOI Listing

Porin from Marine Bacterium KMM 3633: Isolation, Physico-Chemical Properties, and Functional Activity.

Molecules 2020 Jul 8;25(14). Epub 2020 Jul 8.

N. F. Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of Russia, Gamaleya Str., 18, 123098 Moscow, Russia.

KMM 3633, extreme living marine bacterium was isolated from a sample of coastal sea ice in the Amursky Bay near Vladivostok, Russia. The goal of our investigation is to study outer membrane channels determining cell permeability. Porin from KMM 3633 (MpOmp) has been isolated and characterized. Read More

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http://dx.doi.org/10.3390/molecules25143131DOI Listing

Mambalgin-2 Induces Cell Cycle Arrest and Apoptosis in Glioma Cells via Interaction with ASIC1a.

Cancers (Basel) 2020 Jul 8;12(7). Epub 2020 Jul 8.

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 119997 Moscow, Russia.

Gliomas are fast growing and highly invasive brain tumors, characterized by tumor microenvironment acidification that drives glioma cell growth and migration. Channels containing Acid-sensing Ion Channel 1a subunit (ASIC1a) mediate amiloride-sensitive cation influx in late stage glioma cells, but not in normal astrocytes. Thus, selective targeting of ASIC1a can be a perspective strategy for glioma treatment. Read More

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http://dx.doi.org/10.3390/cancers12071837DOI Listing

Membrane Protein Insertion into and Compatibility with Biomimetic Membranes.

Adv Biosyst 2017 Jul 16;1(7):e1700053. Epub 2017 Jun 16.

Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.

Membrane protein and membrane protein-mimic functionalized materials are rapidly gaining interest across a wide range of applications, including drug screening, DNA sequencing, drug delivery, sensors, water desalination, and bioelectronics. In these applications, material performance is highly dependent on activity-per-protein and protein packing density in bilayer and bilayer-like structures collectively known as biomimetic membranes. However, a clear understanding of, and accurate tools to study these properties of biomimetic membranes does not exist. Read More

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http://dx.doi.org/10.1002/adbi.201700053DOI Listing

Three computational methods for studying permeation, selectivity and dynamics in biological ion channels.

Soft Matter 2005 Nov;1(6):417-427

School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Perth, Australia.

The cell membrane, confining some ions and molecules on one side and exchanging others with the other side, is the ultimate unit of the physiology of life. The delicate task of regulating the transport of ions across the membrane is carried out by biological nanotubes called 'ion channels'. Recently, there have been enormous strides in our understanding of the structure-function relationships of biological ion channels. Read More

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http://dx.doi.org/10.1039/b512455gDOI Listing
November 2005

Jasmonate and aluminum crosstalk in tomato: Identification and expression analysis of WRKYs and ALMTs during JA/Al-regulated root growth.

Plant Physiol Biochem 2020 Jun 29;154:409-418. Epub 2020 Jun 29.

College of Horticulture, China Agricultural University, Beijing, 100193, China. Electronic address:

The WRKY transcription factors (TFs) are involved in aluminum (Al) stress and jasmonic acid (JA)-regulated resistance responses. WRKYs act as regulators of Al-activated malate transporter (ALMT) proteins (anion channels) by directly binding to their promoters and altering malate efflux, thereby regulating Al ion toxicity in plant roots. JA enhances Al-induced root growth inhibition in Arabidopsis. Read More

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http://dx.doi.org/10.1016/j.plaphy.2020.06.026DOI Listing

Mechanosensitive channels of Corynebacterium glutamicum functioning as exporters of l-glutamate and other valuable metabolites.

Curr Opin Chem Biol 2020 Jul 6;59:77-83. Epub 2020 Jul 6.

Victor Chang Cardiac Research Institute, Lowy Packer Building, Darlinghurst, NSW, 2010, Australia; St Vincent's Clinical School, University of New South Wales, 405 Liverpool St, Darlinghurst, NSW, 2010, Australia.

In the industrial l-glutamate production established on the use of Corynebacterium glutamicum, l-glutamate synthesized intracellularly is exported through mechanosensitive transmembrane channel proteins (MscCG and MscCG2) activated by the force-from-lipids. The involvement of MscCG2 in l-glutamate export by C. glutamicum was demonstrated in 2018; however, MscCG was previously found to be the major exporter of l-glutamate. Read More

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http://dx.doi.org/10.1016/j.cbpa.2020.05.005DOI Listing

Dynamical system based compact deep hybrid network for classification of Parkinson disease related EEG signals.

Neural Netw 2020 Jun 25;130:75-84. Epub 2020 Jun 25.

Faculty of Engineering and Applied Science, University of Regina, 3737 Wascana Parkway, Regina, Saskatchewan, Canada. Electronic address:

Electroencephalogram (EEG) signals accumulate the brain's spiking activities using standardized electrodes placed at the scalp. These cumulative brain signals are chaotic in nature and vary depending upon current physical and/or mental activities. The anatomy of the brain is altered when dopamine releasing neurons die because of Parkinson Disease (PD), a neurodegenerative disorder. Read More

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http://dx.doi.org/10.1016/j.neunet.2020.06.018DOI Listing

Missense mutations affecting Ca-coordination in GCAP1 lead to cone-rod dystrophies by altering protein structural and functional properties.

Biochim Biophys Acta Mol Cell Res 2020 Jul 7:118794. Epub 2020 Jul 7.

Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, I-37134 Verona, Italy. Electronic address:

Guanylate cyclase activating protein 1 (GCAP1) is a neuronal calcium sensor (NCS) involved in the early biochemical steps underlying the phototransduction cascade. By switching from a Ca-bound form in the dark to a Mg-bound state following light activation of the cascade, GCAP1 triggers the activation of the retinal guanylate cyclase (GC), thus replenishing the levels of 3',5'-cyclic monophosphate (cGMP) necessary to re-open CNG channels. Here, we investigated the structural and functional effects of three missense mutations in GCAP1 associated with cone-rod dystrophy, which severely perturb the homeostasis of cGMP and Ca. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2020.118794DOI Listing

VEGF/VEGFR-2 system exerts neuroprotection against Phoneutria nigriventer spider envenomation through PI3K-AKT-dependent pathway.

Toxicon 2020 Jul 7. Epub 2020 Jul 7.

Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil; Department of Biochemistry and Tissue Biology, Institute of Biology, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil. Electronic address:

This study was undertaken to elucidate why VEGF/VEGFR-2 is elevated in the hippocampus of rats injected with Phoneutria nigriventer spider venom (PNV). PNV delays Na channels inactivation; blocks Ca and K channels, increases glutamate release, causes blood-brain breakdown (BBBb), brain edema and severe excitotoxicity. Analytical FT-IR spectroscopy showed profound alteration in molecular biochemical state, with evidences for VEGFR-2 (KDR/Flk-1) signaling mediation. Read More

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http://dx.doi.org/10.1016/j.toxicon.2020.06.019DOI Listing

Parallel Mechanosensory Pathways Direct Oviposition Decision-Making in Drosophila.

Curr Biol 2020 Jul 4. Epub 2020 Jul 4.

School of Life Sciences, Tsinghua-Peking Joint Center for Life Sciences, IDG/McGovern Institute for Brain Research at Tsinghua, Tsinghua University, Beijing 100084, China. Electronic address:

Female Drosophila choose their sites for oviposition with deliberation. Female flies employ sensitive chemosensory systems to evaluate chemical cues for egg-laying substrates, but how they determine the physical quality of an oviposition patch remains largely unexplored. Here we report that flies evaluate the stiffness of the substrate surface using sensory structures on their appendages. Read More

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http://dx.doi.org/10.1016/j.cub.2020.05.076DOI Listing

The Parabrachial Nucleus Directly Channels Spinal Nociceptive Signals to the Intralaminar Thalamic Nuclei, but Not the Amygdala.

Neuron 2020 Jul 1. Epub 2020 Jul 1.

Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science & Intelligence Technology, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China; Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai 201210, China. Electronic address:

The parabrachial nucleus (PBN) is one of the major targets of spinal projection neurons and plays important roles in pain. However, the architecture of the spinoparabrachial pathway underlying its functional role in nociceptive information processing remains elusive. Here, we report that the PBN directly relays nociceptive signals from the spinal cord to the intralaminar thalamic nuclei (ILN). Read More

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http://dx.doi.org/10.1016/j.neuron.2020.06.017DOI Listing

Stability of extemporaneously compounded amiloride nasal spray.

PLoS One 2020 10;15(7):e0232435. Epub 2020 Jul 10.

Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

Anxiety disorders (AD) are the most common mental conditions affecting an estimated 40 million adults in the United States. Amiloride, a diuretic agent, has shown efficacy in reducing anxious responses in preclinical models by inhibiting the acid-sensing ion channels (ASIC). By delivering amiloride via nasal route, rapid onset of action can be achieved due to direct "nose-to-brain" access. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232435PLOS

Design of a wearable four-channel near-infrared spectroscopy system for the measurement of brain hemodynamic responses.

Biomed Tech (Berl) 2020 Jul 10. Epub 2020 Jul 10.

Department of Electronics and Communication Engineering, College of Engineering, Guindy, Anna University, Sardar Patel Road, Chennai, Tamil Nadu, India.

Objectives This work describes the design and development of a four-channel near-infrared spectroscopy system to detect the oxygenated and deoxygenated hemoglobin concentration changes in the brain during various motor tasks. Methods The system uses light-emitting diodes corresponding to two wavelengths of 760 nm and 850 nm sensitive to deoxygenated and oxygenated hemoglobin concentration changes, respectively. The response is detected using a photodetector with an integrated transimpedance amplifier. Read More

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http://dx.doi.org/10.1515/bmt-2019-0291DOI Listing

Gadolinium-Rich Borate Gd(BO)(BO)O Exhibiting a Magnetocaloric Effect.

Inorg Chem 2020 Jul 10. Epub 2020 Jul 10.

Beijing Center for Crystal Research and Development, Key Laboratory of Functional Crystals and Laser Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.

A gadolinium-rich borate Gd(BO)(BO)O was successfully grown by the high-temperature solution method using the RbO-BO flux. The crystal crystallizes in centrosymmetric space group 2/ with lattice constants = 18.4300(2) Å, = 3. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.0c01547DOI Listing

Flexible Salt-Rejecting Photothermal Paper Based on Reduced Graphene Oxide and Hydroxyapatite Nanowires for High-Efficiency Solar Energy-Driven Vapor Generation and Stable Desalination.

ACS Appl Mater Interfaces 2020 Jul 10. Epub 2020 Jul 10.

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P. R. China.

Vapor generation using solar energy is emerging as an efficient technology for wastewater purification and seawater desalination to relieve global water crisis. However, salt deposition on the evaporation surface seriously impairs the long-term steady water evaporation performance. Herein, the flexible salt-rejecting photothermal paper comprising reduced graphene oxide (rGO) and ultralong hydroxyapatite nanowires (HNs) has been developed for high-performance solar energy-driven water evaporation and stable desalination of seawater. Read More

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http://dx.doi.org/10.1021/acsami.0c05986DOI Listing

Global motion detection and censoring in high-density diffuse optical tomography.

Hum Brain Mapp 2020 Jul 10. Epub 2020 Jul 10.

Department of Physics, Washington University in St. Louis, St. Louis, Missouri, USA.

Motion-induced artifacts can significantly corrupt optical neuroimaging, as in most neuroimaging modalities. For high-density diffuse optical tomography (HD-DOT) with hundreds to thousands of source-detector pair measurements, motion detection methods are underdeveloped relative to both functional magnetic resonance imaging (fMRI) and standard functional near-infrared spectroscopy (fNIRS). This limitation restricts the application of HD-DOT in many challenging imaging situations and subject populations (e. Read More

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http://dx.doi.org/10.1002/hbm.25111DOI Listing

Communication Behavior Changes Between Patients With Diabetes And Healthcare Providers Over 9 Years.

J Med Internet Res 2020 Jun 15. Epub 2020 Jun 15.

Faculty of Sciences, Holon Institute of Technology, Holon, IL.

Background: Health organizations and patients interact over different communication channels and are harnessing digital communications for this purpose. Assisting health organizations improving, adapting, introducing new patient-healthcare practitioners' communication channels enhance healthcare services access.

Objective: This retrospective data study aims to assist healthcare administrators and policy makers improving and personalizing the communication between patients and healthcare professionals by expanding the capabilities of current communication channels and introducing new ones. Read More

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http://dx.doi.org/10.2196/17186DOI Listing

Safinamide in the treatment of Parkinson's disease.

Authors:
Thomas Müller

Neurodegener Dis Manag 2020 Jul 10. Epub 2020 Jul 10.

Department of Neurology, St Joseph Hospital Berlin-Weißensee, Gartenstr. 1, 13088 Berlin, Germany.

The deficiency pattern of neurotransmitters is heterogeneous in patients with Parkinson's disease. Consequence is an individual variable expression of motor and nonmotor features. They respond to agents with a broader spectrum of mode of actions, whereas dopamine substitution only targets impaired motor behavior. Read More

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http://dx.doi.org/10.2217/nmt-2020-0017DOI Listing

General Formation of Macro-/Mesoporous Nanoshells from Interfacial Assembly of Irregular Mesostructured Nanounits.

Angew Chem Int Ed Engl 2020 Jul 9. Epub 2020 Jul 9.

University of Queensland, Australian Institute for Bioengineering and Nanotechnology, AUSTRALIA.

Mesoporous core-shell nanostructures holding controllable ultra-large open channels in their nanoshells are of great interests for the development of new catalytic platforms, electrochemical energy systems, and biological macromolecular carriers. However, soft template-directed cooperative assembly to mesoporous nanoshells with highly accessible pores larger than 30 nm, or even above 50 nm into macroporous range, remains a significant challenge. Herein we report a general approach for precisely tailored coating of hierarchically macro-/mesoporous polymer and carbon shells, possessing highly accessible radial channels with extremely wide pore size distribution from ~10 nm to ~200 nm, on diverse functional materials. Read More

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http://dx.doi.org/10.1002/anie.202007031DOI Listing

Phenylalkylamines in calcium channels: computational analysis of experimental structures.

J Comput Aided Mol Des 2020 Jul 10. Epub 2020 Jul 10.

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russian Federation.

Experimental 3D structures of calcium channels with phenylalkylamines (PAAs) provide basis for further analysis of atomic mechanisms of these important cardiovascular drugs. In the crystal structure of the engineered calcium channel CavAb with Br-verapamil and in the cryo-EM structure of the Cav1.1 channel with verapamil, the ligands bind in the inner pore. Read More

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http://dx.doi.org/10.1007/s10822-020-00330-0DOI Listing

Correction to: Channelopathies of voltage-gated L-type Cav1.3/α and T-type Cav3.1/α Ca channels in dysfunction of heart automaticity.

Pflugers Arch 2020 Jul 9. Epub 2020 Jul 9.

Institut de Génomique Fonctionnelle, CNRS, INSERM, Université de Montpellier, 141, rue de la cardonille, 34094, Montpellier, France.

The above article was published online with an error in Fig. 1b. There is a doubled action potential at the far right of the left panel of the figure. Read More

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http://dx.doi.org/10.1007/s00424-020-02431-zDOI Listing

Tuning the electronic energy level of covalent organic frameworks for crafting high-rate Na-ion battery anode.

Nanoscale Horiz 2020 Jul 10. Epub 2020 Jul 10.

Department of Chemistry, Indian Institute of Science Education and Research, Pune, India. and Centre for Energy Science, Indian Institute of Science Education and Research, Pune, India.

Crystalline Covalent Organic Frameworks (COFs) possess ordered accessible nano-channels. When these channels are decorated with redox-active functional groups, they can serve as the anode in metal ion batteries (LIB and SIB). Though sodium's superior relative abundance makes it a better choice over lithium, the energetically unfavourable intercalation of the larger sodium ion makes it incompatible with the commercial graphite anodes used in Li-ion batteries. Read More

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http://dx.doi.org/10.1039/d0nh00187bDOI Listing

Inactivation in the potassium channel KcsA.

J Struct Biol X 2019 Jul-Sep;3:100009. Epub 2019 Jun 12.

Department of Chemistry, Columbia University, New York, NY 10027, United States.

Inactivation, the slow cessation of transmission after activation, is a general feature of potassium channels. It is essential for their function, and malfunctions in inactivation leads to numerous pathologies. The detailed mechanism for the C-type inactivation, distinct from the N-type inactivation, remains an active area of investigation. Read More

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http://dx.doi.org/10.1016/j.yjsbx.2019.100009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337057PMC

Application of Sysmex XN-Series Automated Haematology Analyser in the Rapid Detection of Malaria.

Indian J Hematol Blood Transfus 2020 Jul 3;36(3):512-518. Epub 2020 Apr 3.

Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, 110029 India.

Malaria, an important parasitic disease worldwide, still has diagnostic challenges in the laboratory. Many studies have been conducted on the detection ability of haematology analysers for malaria. We evaluated the Sysmex XN-series analyser as a tool for detection of malaria by analysing the leukocyte cell population data (LCPD), scattergrams and associated Flow Cytometry Standard (FCS) data from both the WNR (white cell nucleated) and WDF (white cell differential) channels. Read More

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http://dx.doi.org/10.1007/s12288-020-01276-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326751PMC

Ge quantum wire memristor.

Nanotechnology 2020 Jul 10. Epub 2020 Jul 10.

Institute of Solid State Electronics, Technische Universität Wien, Vienna, AUSTRIA.

Despite being known for decades, the actual realization of memory devices based on the memristive effect is progressing slowly, due to processing requirements and the need for exotic materials which are not compatible with today's Complementary-Metal-Oxide-Semiconductor (CMOS) technology. Here, we report an experimental study on a Ge quantum wire device featuring distinct signatures of memristive behavior favorable for integration in CMOS platform technology. Embedding the quasi-1D Ge quantum wire into an electrostatically modulated back-gated field-effect transistor we demonstrate that individual current transport channels can be addressed directly by controlling the surface trap assisted electrostatic gating. Read More

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http://dx.doi.org/10.1088/1361-6528/aba46bDOI Listing

Comparative Studies on Vertical-Channel Charge-Trap Memory Thin-Film Transistors Using In-Ga-Zn-O Active Channels Deposited by Sputtering and Atomic Layer Depositions.

Nanotechnology 2020 Jul 10. Epub 2020 Jul 10.

Kolon Industries Inc, Gwacheon, Gyeonggi-do, Korea (the Republic of).

Vertical-channel charge-trap memory thin film-transistors (V-CTM TFTs) using oxide semiconductors were fabricated and characterized, in which In-Ga-Zn-O (IGZO) channels were prepared by sputtering and atomic-layer deposition (ALD) methods to elucidate the effects of deposition process. The vertical-channel gate stack of the fabricated device was verified to be well implemented on the vertical sidewall of the spacer patterns due to excellent step-coverage and self-limiting mechanisms of ALD process. The V-CTM TFTs using ALD-IGZO channel exhibited a wide memory window (MW) of 15. Read More

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http://dx.doi.org/10.1088/1361-6528/aba46eDOI Listing

Isoform-specific regulation of HCN4 channels by a family of endoplasmic reticulum proteins.

Proc Natl Acad Sci U S A 2020 Jul 9. Epub 2020 Jul 9.

Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045;

Ion channels in excitable cells function in macromolecular complexes in which auxiliary proteins modulate the biophysical properties of the pore-forming subunits. Hyperpolarization-activated, cyclic nucleotide-sensitive HCN4 channels are critical determinants of membrane excitability in cells throughout the body, including thalamocortical neurons and cardiac pacemaker cells. We previously showed that the properties of HCN4 channels differ dramatically in different cell types, possibly due to the endogenous expression of auxiliary proteins. Read More

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http://dx.doi.org/10.1073/pnas.2006238117DOI Listing

Prototypical pacemaker neurons interact with the resident microbiota.

Proc Natl Acad Sci U S A 2020 Jul 9. Epub 2020 Jul 9.

Department of Cell and Developmental Biology, Zoological Institute, University of Kiel, D-24118 Kiel, Germany;

Pacemaker neurons exert control over neuronal circuit function by their intrinsic ability to generate rhythmic bursts of action potential. Recent work has identified rhythmic gut contractions in human, mice, and hydra to be dependent on both neurons and the resident microbiota. However, little is known about the evolutionary origin of these neurons and their interaction with microbes. Read More

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http://dx.doi.org/10.1073/pnas.1920469117DOI Listing

Architecture of a catalytically active homotrimeric plant cellulose synthase complex.

Science 2020 Jul 9. Epub 2020 Jul 9.

Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, 480 Ray C. Hunt Dr., Charlottesville, VA 22903, USA.

Cellulose is an essential plant cell wall component and represents the most abundant biopolymer on Earth. Supramolecular plant cellulose synthase complexes organize multiple linear glucose polymers into microfibrils as load-bearing wall components. We determined the structure of a poplar cellulose synthase CesA homotrimer that suggests a molecular basis for cellulose microfibril formation. Read More

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http://dx.doi.org/10.1126/science.abb2978DOI Listing

F-SMBT-1: A Selective and Reversible Positron-Emission Tomography Tracer for Monoamine Oxidase-B Imaging.

J Nucl Med 2020 Jul 9. Epub 2020 Jul 9.

Tohoku Medical and Pharmaceutical University, Japan.

Reactive astrocytes play a key role in the pathogenesis of various neurodegenerative diseases. Monoamine oxidase-B (MAO-B) is one of the promising targets for the imaging of astrogliosis in the human brain. A novel selective and reversible MAO-B tracer, (S)-(2-methylpyrid-5-yl)-6-[(3-[F]fluoro-2-hydroxy)propoxy]quinoline, (F-SMBT-1), was successfully developed via lead optimization from first-generation tau positron-emission tomography (PET) tracer F-THK-5351. Read More

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http://dx.doi.org/10.2967/jnumed.120.244400DOI Listing

Novel TRPV6 mutations in the spectrum of transient neonatal hyperparathyroidism.

J Physiol Sci 2020 Jul 9;70(1):33. Epub 2020 Jul 9.

Division of Cell Signaling, National Institute for Physiological Sciences (Exploratory Research Center on Life and Living Systems), National Institutes of Natural Sciences, Okazaki, 444-8787, Japan.

Maternal-fetal calcium (Ca) transport in the placenta plays a critical role in maintaining fetal bone mineralization. Mutations in the gene encoding the transient receptor potential cation channel, subfamily V, member 6 (TRPV6) have been identified as causative mutations of transient neonatal hyperparathyroidism due to insufficient maternal-fetal Ca transport in the placenta. In this study, we found two novel mutations in subjects that have transient neonatal hyperparathyroidism. Read More

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http://dx.doi.org/10.1186/s12576-020-00761-2DOI Listing