Search Our Scientific Publications & Authors

Harefuah 2022 Jun;161(6):361-366

Rambam Medical Center.

Introduction: Cycling in Israel: Cycling in Israel is a common sport which is considered to be beneficial to health. However, questions arise about its impact on bone health, due to publications reporting a decrease in bone density in cyclists and the presence of fractures that characterize a relatively older population in relatively young cyclists. Exercise and bone health: It has been proven that a sporty lifestyle, exercise in general and cycling in particular, lowers the chance of fractures of the proximal femur. Read More

PeerJ 2022 15;10:e13445. Epub 2022 Jun 15.

Department of Orthopedics, Langfang People's Hospital, Langfang, Hebei Province, China.

Objective: The aim of this study was to investigate the effect of skeletal sarcopenia on the prognosis of intertrochanteric fracture in the elderly.

Methods: We collected information on 144 patients with femoral intertrochanteric fracture (FIF). The influence of sarcopenia on the chance of death was determined using binary Probit regression analysis. Read More

Chin Med 2022 Jun 14;17(1):70. Epub 2022 Jun 14.

College of Veterinary Medicine and Cardiovascular Research Institute, Kyungpook National University, 80 Daehak-ro, Daegu, 41566, Republic of Korea.

Background: Recent years, a soaring number of marketed Trifolium pratense (red clover) extract products have denoted that a rising number of consumers are turning to natural alternatives to manage postmenopausal symptoms. T. pratense ethanolic extract (TPEE) showed immense potential for their uses in the treatment of menopause complications including osteoporosis and hormone dependent diseases. Read More

JBJS Essent Surg Tech 2022 Jan-Mar;12(1). Epub 2022 Feb 16.

Hip Surgery Unit, Institute of Orthopaedics "Carlos E. Ottolenghi," Italian Hospital of Buenos Aires, Buenos Aires, Argentina.

Revision total hip arthroplasty in the setting of extensive femoral bone loss poses a considerable challenge to the adult reconstructive surgeon. When the proximal femoral bone stock is deficient or absent, there are few options for reconstruction. In such cases, treatment options include distal cementless fixation (either modular or nonmodular), impaction bone grafting (IBG), a megaprosthesis, or even an allograft-prosthesis composite. Read More

JBJS Essent Surg Tech 2021 Oct-Dec;11(4). Epub 2021 Dec 22.

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

A triplane fracture is an example of a transitional fracture of adolescence that occurs because the distal tibial physis closes in a predictably asymmetric way from central to medial and then lateral. The triplane fracture is so named because the fracture lines propagate in 3 planes (axial, sagittal, and coronal) and thus appear on radiographs as a Salter-Harris III pattern on anteroposterior images and Salter-Harris II or IV on lateral images. The fracture occurs via a twisting mechanism (usually supination and external rotation) through the relatively weak open portion of the physis (axial) and propagates out the metaphysis (coronal) and/or epiphysis (sagittal) at the transition to the relatively stronger closed portion of the physis. Read More

JBJS Essent Surg Tech 2022 Jan-Mar;12(1). Epub 2022 Feb 16.

Department of Orthopedic Surgery, University of Minnesota, Minneapolis, Minnesota.

For stable intertrochanteric hip fractures, treatment commonly involves the use of a sliding hip screw. Intertrochanteric hip fractures are increasingly common as the population ages and lives longer. More than 250,000 hip fractures occur per year in the United States. Read More

Clin Oral Investig 2022 Jun 4. Epub 2022 Jun 4.

Department of Biomaterials and Oral Biology, School of Dentistry, University of São Paulo, São Paulo, SP, Brazil.

Objectives: This systematic review was performed to determine the main cause of technical failure of tooth-supported zirconia crowns and fixed partial dentures (FPDs), categorizing them as fracture/chipping or loss of retention/decementation.

Materials And Methods: Electronic and manual searches were performed for randomized clinical trials, prospective clinical trials, and prospective cohort studies that reported the technical failure rates of zirconia restorations. The Cochrane Collaboration risk-of-bias tool and Newcastle-Ottawa scale were used to assess the quality of the studies. Read More

Future Oncol 2022 Jul 3;18(21):2585-2597. Epub 2022 Jun 3.

Division of Urology, IREC, Cliniques Universitaires Saint Luc, UCLouvain, Brussels, Belgium.

What Is This Summary About?: This is a summary of a publication about the ARASENS trial, which was published in the in February 2022. The trial includes 1,306 men with a type of prostate cancer called metastatic, hormone-sensitive prostate cancer (also called mHSPC). In the trial, researchers wanted to learn if combining a treatment called darolutamide (also known by the brand name Nubeqa) with two other medicines called androgen deprivation therapy (also called ADT) and docetaxel (brand name Taxotere) could help treat patients with mHSPC better than placebo plus ADT and docetaxel. Read More

Cancer Rep (Hoboken) 2022 May 25:e1628. Epub 2022 May 25.

Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin, PR China.

Background: With more and more target medicine application in lung cancer, lots of patients take medicine at home, the treatment bone metastasis and screen of bone metastasis always has been neglected until skeletal-related events (SREs) such as bone pain, hypercalcemia of malignancy and pathologic fractures emerging which significantly impairs the patients' daily activity ability, seriously lower quality of life.

Aim: To identify the clinical characteristics of patients which influence the overall survival (OS) of EGFR-TKIs effective in EGFR-mutant NSCLC with bone metastasis (BM) and the bone metastatic image features.

Methods: We conducted a retrospective study in patients (treated with EGFR-TKIs ≥6 months) of lung adenocarcinoma with BM in our hospital from October 2014 to October 2017. Read More

J Interv Cardiol 2022 4;2022:4368887. Epub 2022 May 4.

Cariovascular Surgery, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

Transcatheter aortic valve replacement (TAVR) to treat degeneration of bioprosthetic heart valves (BHVs), called as valve-in-valve (ViV), is becoming a key feature since the number of BHVs requiring intervention is increasing and many patients are at high risk for a redo cardiac surgery. However, a TAVR inside a small previous cardiac valve may lead to prosthesis-patient mismatch (PPM) and not be as effective as we hoped for. An effective option to decrease the chance of PPM is to fracture the previous heart valve implanted using a high-pressure balloon. Read More

Am Surg 2022 May 13:31348221102607. Epub 2022 May 13.

Department of Surgery, Division of Pediatric Surgery, 12239Emory University, Atlanta, GA, USA.

Background: Chance fracture (CFx) with concomitant intra-abdominal injury has variable occurrence rates ranging from 33 to 89%. No single study has compared the incidence of simultaneous abdominal injury between pediatric and adult populations. This study compares the rate of simultaneous intra-abdominal injury and chance fracture in these populations. Read More

J Pediatr Orthop 2022 May 12. Epub 2022 May 12.

Department of Orthopedics and Scoliosis Surgery, Texas Children's Hospital.

Background: Supracondylar humerus fractures (SCHF) are the most common elbow fracture type in children, and one of the most common pediatric fracture types overall. Excellent outcomes are generally reported with closed reduction and pinning (CRPP), but the technique involves leaving the pins outside the skin. External pins can act as a nidus for infection. Read More

J Oral Maxillofac Surg 2022 Apr 7. Epub 2022 Apr 7.

Department Head, Department of Oral and Maxillofacial Surgery, Rambam Medical Care Center, Haifa, Israel, and Ruth & Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Purpose: Identify associations between preoperative radiographic measurements and clinical findings of zygomatic arch fractures and postoperative radiographic measurements. Based on those findings, propose a comprehensive treatment algorithm for the solitary zygomatic arch fracture and combined zygomatic arch-zygomatic complex fracture.

Methods: Retrospective cohort study with patients referred to our department for zygomatic arch fractures between 2013 and 2018. Read More

J Psychiatr Res 2022 Jul 1;151:299-303. Epub 2022 May 1.

Center for Pharmacoepidemiology Research and Training, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

Benzodiazepine receptor agonists and related medications, such as Z-drugs and dual orexin receptor antagonists (BZDs), have been associated with unintentional traumatic injury due to their central nervous system (CNS)-depressant effects. Drug-drug interactions (DDIs) may contribute to the known relationship between BZD use and unintentional traumatic injury, yet evidence is still lacking. We conducted high-throughput pharmacoepidemiologic screening using the self-controlled case series design in a large US commercial health insurance database to identify potentially clinically relevant DDI signals among new users of BZDs. Read More

Cureus 2022 Mar 10;14(3):e23018. Epub 2022 Mar 10.

Department of Orthopaedics, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, IND.

Background Tibial shaft fractures account for 17% of all lower limb fractures. Nonunion and infection rates are estimated to be between 2% and 10%. Bone healing is a complex process that is influenced by biological, mechanical, and systemic factors. Read More

Emerg Med Australas 2022 Apr 20. Epub 2022 Apr 20.

Department of Surgery, Rockhampton Hospital, Rockhampton, Queensland, Australia.

Objective: First rib fractures (FRFs) have historically been a marker for severe trauma and poor outcomes. The aim of the present study was to assess whether an association still exists between a fractured first rib and global trauma scores suffered by the patient, examine mortality rates and identify other commonly associated injuries.

Methods: This retrospective study examined records collected from patients from the Rockhampton Hospital with a traumatic FRF from July 2015 to June 2020. Read More

J Orthop Case Rep 2021 Jun;11(6):63-67

Department of Orthopaedic Surgery, Zucker School of Medicine at Hofstra/Northwell, Plainview, New York, United States.

Introduction: Perilunate dislocations are rare high-energy injuries, and the diagnosis is not infrequently missed at initial presentation. The combination of fractures resulting in a trans-styloid, trans-scaphoid, and trans-triquetral perilunate fracture dislocation is extremely rare. Early recognition and diagnosis of these injuries is prudent to restore patient function and prevent morbidity. Read More

J Orthop Case Rep 2021 Jun;11(6):32-35

Department of Orthopaedics, Grant Government Medical College, Mumbai, Maharashtra, India.

Introduction: Neck of femur fractures is the most common fractures in elderly people as they present with osteoporosis. There is a higher chance of proximal femur fracture in a schizophrenic patient as there is a loss of bone mineral density due to a drug-induced increase in the level of prolactin and immobility. Patients with Parkinson's disease were at higher risk for the development of hip fractures due to gait disturbances and instability. Read More

Surgeon 2022 Mar 28. Epub 2022 Mar 28.

Edinburgh Orthopaedics, Royal Infirmary of Edinburgh, UK; Scottish Orthopaedic Research Trust Into Trauma (SORT-IT), UK; Department of Orthopaedics & Trauma and Usher Institute, University of Edinburgh, UK.

Aims: This international study aimed to assess: 1) the prevalence of preoperative and postoperative COVID-19 among patients with hip fracture, 2) the effect on 30-day mortality, and 3) clinical factors associated with the infection and with mortality in COVID-19-positive patients.

Methods: A multicentre collaboration among 112 centres in 14 countries collected data on all patients presenting with a hip fracture between 1st March-31st May 2020. Demographics, residence, place of injury, presentation blood tests, Nottingham Hip Fracture Score, time to surgery, management, ASA grade, length of stay, COVID-19 and 30-day mortality status were recorded. Read More

J Clin Med 2022 Mar 25;11(7). Epub 2022 Mar 25.

Department of Periodontology and Oral Implantology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

Background: Medication-related osteonecrosis of the jaws (MRONJ) is a mucosal lesion of the maxillofacial region with necrotic bone exposure. MRONJ is believed to be multifactorial. Tooth extraction is debatably a risk factor for MRONJ. Read More

Cureus 2022 Feb 15;14(2):e22259. Epub 2022 Feb 15.

General Medicine, Surrey Docks Health Center, London, GBR.

Introduction Implantation of cardiac implantable electronic devices (CIEDs) is an art of science. As the volume of implantation has increased worldwide, so has the rate of complications. Infection, fibrosis, lead and device erosion, lead displacement, right ventricle perforation, lead fracture, and insulation break are the common complications in the implantation process. Read More

J Am Acad Orthop Surg 2022 Mar 24. Epub 2022 Mar 24.

From the Department of Orthopedic Surgery (Valero-Moreno, Kaplan, Bineth, and Schroeder) and the Department of Neurosurgery (Cohen), Hebrew University Hadassah Medical Center, Kalman Ya'akov Man St, Jerusalem, Israel.

Introduction: Unstable fractures in sick or elderly patients are on the rise. These patients who are at high risk for surgery present a challenge for surgeons and anesthesiologists. In patients with American Society of Anesthesiologists (ASA) scores 3 to 4, the risk is even higher because of the high rate of intraoperative complications. Read More

J Vasc Surg Cases Innov Tech 2022 Jun 27;8(2):129-131. Epub 2022 Jan 27.

Division of Vascular and Endovascular Surgery, Department of Surgery, Saint Louis University, St. Louis, Mo.

We present a 4-year-old who suffered blunt abdominal trauma leading to Chance fractures to the lumbar spine, bucket-handle injuries to the ileum and descending colon, and an aortic intimal injury leading to occlusion of the infrarenal aorta with extension to the bifurcation. Her vascular injuries were managed by endarterectomy of the intimal injury, thrombectomy of the distal aorta and bilateral iliac arteries using a Fogarty catheter, and patch angioplasty of the infrarenal aorta using bovine pericardium secured by a combination of interrupted and running sutures to optimize elasticity and operative time. Read More

Gerontology 2022 Mar 21:1-13. Epub 2022 Mar 21.

Institute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary.

Background: Anaemia and osteoporotic fractures are both major health problems among older adults worldwide.

Objectives: Previous studies suggest that anaemia may be associated with elevated fracture risk among older adults; however, the exact relationship between them is unknown. We aimed to investigate the association between anaemia and fracture risk. Read More

J Am Med Dir Assoc 2022 04 2;23(4):671-677.e4. Epub 2022 Mar 2.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Objectives: We examined whether the comorbidity burden of patients with hip fracture was associated with quality of in-hospital care reflected by fulfillment of process performance measures.

Design: Population-based cohort study using prospectively collected data from the Danish Multidisciplinary Hip Fracture Registry (DMHFR).

Setting And Participants: Patients aged 65 years or older with an incident hip fracture from 2014 to 2018 registered in the DMHFR (n = 31,443). Read More

Clin Orthop Relat Res 2022 06 28;480(6):1170-1177. Epub 2022 Feb 28.

Department of Trauma Surgery, Radboud University Medical Centre and Radboud University, Nijmegen, the Netherlands.

Background: Tibial plateau fractures are often complex, and they can be challenging to treat. Classifying fractures is often part of the treatment process, but intra- and interobserver reliability of fracture classification systems often is inadequate to the task, and classifications that lack reliability can mislead providers and result in harm to patients. Three-dimensionally (3D)-printed models might help in this regard, but whether that is the case for the classification of tibial plateau fractures, and whether the utility of such models might vary by the experience of the individual classifying the fractures, is unknown. Read More

Health Technol Assess 2022 02;26(11):1-80

AToMS Academic Team of Musculoskeletal Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK.

Background: Patients with a displaced fracture of the distal radius are frequently offered surgical fixation. Manipulation of the fracture and moulded plaster casting is an alternative treatment that avoids metal implants, but evidence of its effectiveness is lacking.

Objective: To compare functional outcomes, quality-of-life outcomes, complications and resource use among patients with a dorsally displaced fracture of the distal radius treated with manipulation and surgical fixation with Kirschner wires (K-wires) and those treated with manipulation and moulded cast. Read More

J Orthop 2022 Jan-Feb;29:65-70. Epub 2022 Jan 29.

Department of Orthopaedics, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, 600116, India.

Introduction: Intra-medullary devices are the most common mode of fixation of inter-trochanteric fractures. Short proximal femur nails (PFN) used for fixing these fractures, unlike the long nails, are non-anatomic and are usually straight with no curvature in antero-posterior plane. As a result, there is always a chance of the nail tip impinging against the anterior cortex of femur. Read More