17,061 results match your criteria Chagas Disease American Trypanosomiasis


In vitro activity of steroidal dendrimers on Trypanosoma cruzi epimastigote form with PAMAM dendrons modified by "click" chemistry.

Bioorg Chem 2019 Jan 28;86:452-458. Epub 2019 Jan 28.

Unidad de Bioquímica e Inmunología, División de Estudios de Posgrado e Investigación, Instituto Tecnológico de Oaxaca, Av. Ing. Víctor Bravo Ahuja #125 esq, Clz. Tecnológico, C.P. 68030 Oaxaca, Mexico; Centro de Investigación Facultad de Medicina UNAM-UABJO, Facultad de Medicina y Cirugía, Universidad Autónoma "Benito Juárez" de Oaxaca, Ex Hacienda de Aguilera S/N, Carretera a San Felipe del Agua, C.P. 68020 Oaxaca, Mexico. Electronic address:

The increasing use of dendrimers shows promise for the treatment of inflammatory diseases, Chagas disease and other conditions such as cancer. In this study, the activity of 1st and 2nd generation dendrimers over T. cruzi in the epimastigote stage was tested. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.01.056DOI Listing
January 2019

Quantitative label-free mass spectrometry using contralateral and adjacent breast tissues reveal differentially expressed proteins and their predicted impacts on pathways and cellular functions in breast cancer.

J Proteomics 2019 Feb 14. Epub 2019 Feb 14.

Genetics Department, Federal University of Parana, Curitiba, Brazil. Electronic address:

Proteins play an essential role in the biological processes associated with cancer. Their altered expression levels can deregulate critical cellular pathways and interactive networks. In this study, the mass spectrometry-based label-free quantification followed by functional annotation was performed to investigate the most significant deregulated proteins among tissues of primary breast tumor (PT) and axillary metastatic lymph node (LN) and corresponding non-tumor tissues contralateral (NCT) and adjacent (ANT) from patients diagnosed with invasive ductal carcinoma. Read More

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http://dx.doi.org/10.1016/j.jprot.2019.02.007DOI Listing
February 2019

Cloning, expression and purification of 3'-nucleotidase/nuclease, an enzyme responsible for the Leishmania escape from neutrophil extracellular traps.

Mol Biochem Parasitol 2019 Feb 14. Epub 2019 Feb 14.

Instituto de Bioquímica Médica Leopoldo de Meis (IBqM), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil. Electronic address:

Leishmaniasis is one of the most significant of the neglected tropical diseases, with 350 million people in 98 countries worldwide living at risk of developing one of the many forms of the disease. During the transmission of the parasite from its vector to the vertebrate host, neutrophils are rapidly recruited to the site of the sandfly bite. Using different strategies, neutrophils can often kill a large number of parasites. Read More

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http://dx.doi.org/10.1016/j.molbiopara.2019.02.004DOI Listing
February 2019

First report of family clusters of Chagas disease seropositive blood donors in Mexico City and their epidemiological relevance.

Acta Trop 2019 Feb 13. Epub 2019 Feb 13.

Hospital de Infectología, Centro Médico "La Raza", Instituto Mexicano del Seguro Social, Mexico.

Background: Chagas disease is an important health problem in Latin America. Relatives of T. cruzi seropositive donors could also test positive in serological assays. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.014DOI Listing
February 2019

Morphological Study of the urotergite I process in Ten Species of the Genus Triatoma (Hemiptera, Reduviidae, Triatominae).

Acta Trop 2019 Feb 12. Epub 2019 Feb 12.

Laboratory of Entomology in Public Health, Department of Epidemiology, School of Public Health, University of São Paulo, Av. Dr. Arnaldo, 715, Pinheiros, São Paulo, São Paulo, CEP 01246-904, Brazil.

The insects of subfamily Triatominae exhibit many morphological features used for taxonomic identification. In some species, however, these features are very similar. The authors have proposed by first time the description of the structure referred as urotergite I process. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.012DOI Listing
February 2019

Life Cycle, Feeding, and Defecation Patterns of Triatoma carrioni (Hemiptera: Reduviidae), Under Laboratory Conditions.

J Med Entomol 2019 Feb 15. Epub 2019 Feb 15.

Center for Research on Health in Latin America (CISeAL).

Chagas disease is caused by Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae). It is transmitted to humans primarily through contaminated feces of blood-sucking vectors of the subfamily Triatominae, known in Ecuador as 'chinchorros'. Some Triatominae species can adapt to domiciliary and peridomiciliary environments where T. Read More

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http://dx.doi.org/10.1093/jme/tjz004DOI Listing
February 2019

Chagas disease, cardioembolic ischemic stroke, INR control and bleeding.

Arq Neuropsiquiatr 2019 Jan;77(1):65

Dr DY Patil University, Pune, India.

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http://dx.doi.org/10.1590/0004-282X20180152DOI Listing
January 2019

5-HT serotonin receptor in the gastrointestinal tract: the link between immune system and enteric nervous system in the digestive form of Chagas disease.

Parasitol Res 2019 Feb 12. Epub 2019 Feb 12.

Human Anatomy Sector, Neurosciences Laboratory, ICBIM, Campus Umuarama, Universidade Federal de Uberlândia, Uberlândia, Minas Gerais, 38400-902, Brazil.

Chagas disease is caused by Trypanosoma cruzi and remains one of the most neglected diseases in Latin America. One of its clinical forms is Chagas megacolon. Despite being known for more than half a century, detailed causes are still obscure. Read More

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http://dx.doi.org/10.1007/s00436-019-06241-wDOI Listing
February 2019

Chagas Cardiomyopathy in Latin America Review.

Curr Cardiol Rep 2019 Feb 12;21(2). Epub 2019 Feb 12.

Messejana Heart and Lung Hospital Dr. Carlos Alberto Studart Gomes, Av. Frei Cirilo, 3480 Messejana, Fortaleza, CE, 60.846-190, Brazil.

Purpose Of Review: Chagas cardiomyopathy is a major public health disease in Latin America and, due to migration, is becoming a worldwide health and economic burden. This review sought to present the clinical and epidemiological aspects of Chagas cardiomyopathy, as well as some specific features and principles of treatment. We also retrospectively assessed our institutional experience with mechanical circulatory support in refractory heart failure due to Chagas cardiomyopathy over a 10-year period. Read More

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http://dx.doi.org/10.1007/s11886-019-1095-yDOI Listing
February 2019
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Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates.

J Vis Exp 2019 Jan 27(143). Epub 2019 Jan 27.

Chagas Disease Multidisciplinary Research Laboratory, Faculty of Medicine, University of Brasilia;

American trypanosomiasis is transmitted to humans by triatomine bugs through the ingestion of contaminated food, by blood transfusions or accidently in hospitals and research laboratories. In addition, the Trypanosoma cruzi infection is transmitted congenitally from a chagasic mother to her offspring, but the male partner's contribution to in utero contamination is unknown. The findings of nests and clumps of amastigotes and of trypomastigotes in the theca cells of the ovary, in the goniablasts and in the lumen of seminiferous tubules suggest that T. Read More

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http://dx.doi.org/10.3791/57985DOI Listing
January 2019

Schistosomal Lipids Activate Human Eosinophils via Toll-Like Receptor 2 and PGD Receptors: 15-LO Role in Cytokine Secretion.

Front Immunol 2018 25;9:3161. Epub 2019 Jan 25.

Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil.

Parasite-derived lipids may play important roles in host-pathogen interactions and immune evasion mechanisms. Remarkable accumulation of eosinophils is a characteristic feature of inflammation associated with parasitic disease, especially caused by helminthes. Infiltrating eosinophils are implicated in the pathogenesis of helminth infection by virtue of their capacity to release an array of tissue-damaging and immunoregulatory mediators. Read More

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http://dx.doi.org/10.3389/fimmu.2018.03161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355688PMC
January 2019

Burden of Chagas disease in Brazil, 1990-2016: findings from the Global Burden of Disease Study 2016.

Int J Parasitol 2019 Feb 7. Epub 2019 Feb 7.

Institute of Studies in Public Health, Federal University of Rio de Janeiro, Avenida Horácio Macedo, S/N, Ilha do Fundão - Cidade Universitária, 21941-598 Rio de Janeiro, RJ, Brazil; Department of Epidemiology, Social Medicine Institute, State University of Rio de Janeiro, Rua São Francisco Xavier 524, Maracanã, 20550-013 Rio de Janeiro, RJ, Brazil.

Chagas disease continues to be an important cause of morbidity, mortality and disability in several Latin American countries including Brazil. Using findings from the Global Burden of Disease Study 2016 (GBD 2016), we present years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life years (DALYs) due to Chagas disease in Brazil, by sex, age group, and Brazilian states, from 1990 to 2016. Results are reported in absolute numbers and age-standardized rates (per 100,000 population) with 95% uncertainty intervals (UIs). Read More

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http://dx.doi.org/10.1016/j.ijpara.2018.11.008DOI Listing
February 2019

Feces from wild Triatoma dimidiata induces local inflammation and specific immune response in a murine model

Ann Parasitol 2018 ;64(4):367-377

Centro de Investigaciones Biomédicas, Universidad Autonoma de Campeche, Patrico Trueba s/n, Campeche 24090, Mexico

In endemic regions for Triatoma dimidiata the vector for Chagas disease, subjects can be in contact with insect`s feces several times through a lifetime. The triatomine’s digestive tract is colonized by diverse but few dominant genera of microorganisms. The immune responses to microbiota feces are poorly known in mammal hosts. Read More

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January 2018

Bone-marrow mononuclear cell therapy in a mouse model of amyotrophic lateral sclerosis: Functional outcomes from different administration routes.

Brain Res 2019 Feb 5. Epub 2019 Feb 5.

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

Amyotrophic lateral sclerosis (ALS) is a chronic degenerative disease that mainly affects motor neurons, leading to progressive paralysis and death. Recently, cell therapy has emerged as a therapeutic alternative for several neurological diseases, including ALS, and bone-marrow cells are one of the major cell sources. Considering the importance of pre-clinical trials to determine the best therapeutic protocol and the hope of translating this protocol to the clinical setting, we tested bone-marrow mononuclear cell (BMMC) therapy administered by different routes in the SOD1 model of ALS. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.02.003DOI Listing
February 2019
1 Read

Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents.

PLoS Negl Trop Dis 2019 Feb 8;13(2):e0007129. Epub 2019 Feb 8.

Northeastern University Department of Chemistry & Chemical Biology, Boston, MA, United States of America.

New treatments are needed for neglected tropical diseases (NTDs) such as Human African trypanosomiasis (HAT), Chagas disease, and schistosomiasis. Through a whole organism high-throughput screening campaign, we previously identified 797 human kinase inhibitors that grouped into 59 structural clusters and showed activity against T. brucei, the causative agent of HAT. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007129DOI Listing
February 2019

[Maternal factors associated to congenital transmission of Chagas disease in children born and siblings in Chaco province, Argentina.]

Rev Fac Cien Med Univ Nac Cordoba 2018 12 27;75(4):279-287. Epub 2018 Dec 27.

Universidad de Buenos Aires.

Introduction: After vector-borne transmission, the congenital form is the most important to maintain the endemic. The probability of congenital transmission may depend on factors that vary between different countries and geographic areas. This study was carried out with the objective of estimating the proportion of congenital transmission of Chagas disease and maternal factors associated to the T. Read More

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http://dx.doi.org/10.31053/1853.0605.v75.n4.21260DOI Listing
December 2018

Multiple Approaches to Address Potential Risk Factors of Chagas Disease Transmission in Northeastern Brazil.

Am J Trop Med Hyg 2019 Feb;100(2):296-302

Laboratório de Ecoepidemiologia da Doença de Chagas, Instituto Oswaldo Cruz, IOC/Fiocruz, Rio de Janeiro, Brazil.

Chagas disease is one of the most significant systemic parasitosis in Latin America, caused by , which is mainly transmitted by hematophagous insects, the triatomines. This research was carried out in both domestic and wild environments throughout a Northeastern rural locality. Triatomines were captured in both peridomicile and wild environments, obtaining 508 specimens of triatomines, of which 99. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367631PMC
February 2019

Trypanocidal Activity, Genomic Analysis of Isolates, and Transcription of Type VI Secretion System of Belonging to the Microbiota of Digestive Tract.

Front Microbiol 2018 24;9:3205. Epub 2019 Jan 24.

Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular (INCT-EM), Rio de Janeiro, Brazil.

is a bacterium with the ability to colonize several niches, including some eukaryotic hosts. have been recently found in the gut of hematophagous insects that act as parasite vectors, such as , and . While some strains have been reported as symbiotic or pathogenic to other insects, the role of populations from the gut microbiota of , a vector of Chagas' disease, remains unknown. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353840PMC
January 2019
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Development and characterization of benznidazole nano- and microparticles: A new tool for pediatric treatment of Chagas disease?

Colloids Surf B Biointerfaces 2019 Jan 23;177:169-177. Epub 2019 Jan 23.

Instituto de Química Rosario, Consejo Nacional de Investigaciones Científicas y Técnicas (IQUIR-CONICET), Suipacha 531, 2000, Rosario, Argentina; Área Técnica Farmacéutica, Departamento de Farmacia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina. Electronic address:

Benznidazole (BNZ) is the drug of choice for the treatment of Chagas disease in many countries. However, its low water solubility produces low and/or variable oral bioavailability. Thus, the aim of this work was to formulate micro- and nanoparticles based on Eudragit RS PO and Eudragit RL PO as a convenient approach to increase the dissolution rate of BNZ. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.039DOI Listing
January 2019
2 Reads

Taxonomical over splitting in the Rhodnius prolixus (Insecta: Hemiptera: Reduviidae) clade: Are R. taquarussuensis (da Rosa et al., 2017) and R. neglectus (Lent, 1954) the same species?

PLoS One 2019 7;14(2):e0211285. Epub 2019 Feb 7.

Grupo de Investigaciones Microbiológicas-UR (GIMUR), Programa de Biología, Facultad de Ciencias Naturales y Matemáticas, Universidad del Rosario, Bogotá, Colombia.

The use of subtle features as species diagnostic traits in taxa with high morphological similarity sometimes fails in discriminating intraspecific variation from interspecific differences, leading to an incorrect species delimitation. A clear assessment of species boundaries is particularly relevant in disease vector organisms in order to understand epidemiological and evolutionary processes that affect transmission capacity. Here, we assess the validity of the recently described Rhodnius taquarussuensis (da Rosa et al. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211285PLOS
February 2019

Description of sp. n., a potential Chagas disease vector (Hemiptera, Reduviidae, Triatominae).

Zookeys 2019 28(820):51-70. Epub 2019 Jan 28.

Department of Biology, University of Vermont, Burlington, Vermont, United States.

A new species of the genus Laporte, 1832 (Hemiptera, Reduviidae) is described based on specimens collected in the department of Huehuetenango, Guatemala. is closely related to (Latreille, 1811), with the following main morphological differences: lighter color; smaller overall size, including head length; and width and length of the pronotum. Natural (Chagas, 1909) infection, coupled with its presence in domestic habitats, makes this species a potentially important vector of in Guatemala. Read More

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http://dx.doi.org/10.3897/zookeys.820.27258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361876PMC
January 2019

Synthesis and biological evaluation of new long-chain squaramides as anti-chagasic agents in the BALB/c mouse model.

Bioorg Med Chem 2019 Mar 29;27(5):865-879. Epub 2019 Jan 29.

Department of Parasitology, Instituto de Investigación Biosanitaria (ibs. Granada), Hospitales Universitarios de Granada/University of Granada, Severo Ochoa s/n, E-18071 Granada, Spain.

Chagas Disease is caused by infection with the insect-transmitted protozoan Trypanosoma cruzi and affects more than 10 million people. It is a paradigmatic example of a chronic disease without an effective treatment in Latin America where the current therapies, based on Benznidazole and Nifurtimox, are characterised by limited efficacy, toxic side-effects and frequent failures in the treatment. We present a series of new long-chain squaramides, identified based on their H and C NMR spectra, and their trypanocidal activity and cytotoxicity were tested in vitro through the determination of IC values. Read More

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http://dx.doi.org/10.1016/j.bmc.2019.01.033DOI Listing

Infectious diseases at different stages of migration: an expert review.

J Travel Med 2019 Feb 6. Epub 2019 Feb 6.

JD MacLean Centre for Tropical Diseases at McGill, McGill University Health Centre, McGill University.

Background: Human migration is increasing in magnitude and scope. The majority of migrants arriving in high income countries originate from countries with a high prevalence of infectious diseases. The risk and burden of infectious diseases are not equally distributed among migrant groups and varies with migration stage. Read More

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http://dx.doi.org/10.1093/jtm/taz007DOI Listing
February 2019
4 Reads

Reprogramming of Trypanosoma cruzi metabolism triggered by parasite interaction with the host cell extracellular matrix.

PLoS Negl Trop Dis 2019 Feb 6;13(2):e0007103. Epub 2019 Feb 6.

Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.

Trypanosoma cruzi, the etiological agent of Chagas' disease, affects 8 million people predominantly living in socioeconomic underdeveloped areas. T. cruzi trypomastigotes (Ty), the classical infective stage, interact with the extracellular matrix (ECM), an obligatory step before invasion of almost all mammalian cells in different tissues. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007103DOI Listing
February 2019
1 Read

Migration Medicine.

Infect Dis Clin North Am 2019 Mar;33(1):265-287

University Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili, Piazza del Mercato, 15, Lombardy, Brescia 25121, Italy; UNESCO Chair "Training and Empowering Human Resources for Health Development in Resource-Limited Countries", University of Brescia, Brescia, Italy.

Migration is increasing and practitioners need to be aware of the unique health needs of this population. The prevalence of infectious diseases among migrants varies and generally mirrors that of their countries of origin, but is modified by the circumstance of migration, the presence of pre-arrival screening programs and post arrival access to health care. To optimize the health of migrants practitioners; (1) should take all opportunities to screen migrants at risk for latent infections such as tuberculosis, chronic hepatitis B and C, HIV, strongyloidiasis, schistosomiasis and Chagas disease, (2) update routine vaccines in all age groups and, (3) be aware of "rare and tropical infections" related to migration and return travel. Read More

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http://dx.doi.org/10.1016/j.idc.2018.10.014DOI Listing
March 2019
1 Read

American Trypanosomiasis (Chagas Disease).

Infect Dis Clin North Am 2019 Mar;33(1):119-134

Division of Cardiology, Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Foothills Medical Centre, Room C823, 1403 29th Street Northwest, Calgary, Alberta T2N 2T9, Canada. Electronic address:

American trypanosomiasis is caused by a parasite endemic of the Americas. Current migration has globalized Chagas disease. Acute infection usually resolves spontaneously. Read More

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http://dx.doi.org/10.1016/j.idc.2018.10.015DOI Listing

Strategies to enhance access to diagnosis and treatment for Chagas disease patients in Latin America.

Expert Rev Anti Infect Ther 2019 Feb 4:1-13. Epub 2019 Feb 4.

a ISGlobal, Hospital Clínic , Universitat de Barcelona , Barcelona , Spain.

Introduction: Chagas disease, caused by infection with the parasite Trypanosoma cruzi, represents a huge public health problem in the Americas, where millions of people are affected. Despite the availability of two drugs against the infection (benznidazole and nifurtimox), multiple factors impede their effective usage: (1) gaps in patient and healthcare provider awareness; (2) lack of access to diagnosis; (3) drug toxicity and absence of treatment algorithms to address adverse effects; (4) failures in drug supply and distribution; and (5) inconsistent drug efficacy against the symptomatic chronic stage. Areas covered: We review new approaches and technologies to enhance access to diagnosis and treatment to reduce the disease burden. Read More

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http://dx.doi.org/10.1080/14787210.2019.1577731DOI Listing
February 2019
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In silico identification and evaluation of new Trypanosoma cruzi trypanothione reductase (TcTR) inhibitors obtained from natural products database of the Bahia semi-arid region (NatProDB).

Comput Biol Chem 2019 Jan 22;79:36-47. Epub 2019 Jan 22.

Laboratório de Bioinformática e Modelagem Molecular (LaBiMM), Universidade Federal da Bahia, Av. Barão de Jeremoabo, 147, Faculdade de Farmácia, Ondina, 40170-115, Salvador, BA, Brazil. Electronic address:

Trypanosoma cruzi Trypanothione Reductase (TcTR) is one of the therapeutic targets studied in the development of new drugs against Chagas' disease. Due to its biodiversity, Brazil has several compounds of natural origin that were not yet properly explored in drug discovery. Therefore, we employed the Virtual Screening against TcTR aiming to discover new inhibitors from the Natural Products Database of the Bahia Semi-Arid region (NatProDB). Read More

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http://dx.doi.org/10.1016/j.compbiolchem.2019.01.009DOI Listing
January 2019

Deep sequencing reveals multiclonality and new discrete typing units of Trypanosoma cruzi in rodents from the southern United States.

J Microbiol Immunol Infect 2018 Dec 21. Epub 2018 Dec 21.

Department of Tropical Medicine, Vector-Borne Infectious Disease Research Center, Tulane University, School of Public Health and Tropical Medicine, New Orleans, LA, USA. Electronic address:

Background/purpose: The parasitic protozoa Trypanosoma cruzi, is widely distributed throughout the Americas. We explored the nature of T. cruzi infection in small rodents from New Orleans (LA, USA), an enzootic region of the parasite in North America. Read More

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http://dx.doi.org/10.1016/j.jmii.2018.12.004DOI Listing
December 2018

Identification of French Guiana sand flies using MALDI-TOF mass spectrometry with a new mass spectra library.

PLoS Negl Trop Dis 2019 Feb 1;13(2):e0007031. Epub 2019 Feb 1.

Laboratoire des Interactions Virus-Hôtes, Institut Pasteur de la Guyane, Cayenne, French Guiana.

Phlebotomine sand flies are insects that are highly relevant in medicine, particularly as the sole proven vectors of leishmaniasis. Accurate identification of sand fly species is an essential prerequisite for eco-epidemiological studies aiming to better understand the disease. Traditional morphological identification is painstaking and time-consuming, and molecular methods for extensive screening remain expensive. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007031DOI Listing
February 2019
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Chagas Disease and the Kissing Bug: An Invisible Giant.

J Cardiothorac Vasc Anesth 2019 Jan 4. Epub 2019 Jan 4.

Department of Cardiovascular Surgery of the Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

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http://dx.doi.org/10.1053/j.jvca.2019.01.014DOI Listing
January 2019

A therapeutic preconceptional vaccine against Chagas disease: A novel indication that could reduce congenital transmission and accelerate vaccine development.

PLoS Negl Trop Dis 2019 01 31;13(1):e0006985. Epub 2019 Jan 31.

Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0006985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354953PMC
January 2019

POEM in Latin America: The Rise of a New Standard.

J Clin Gastroenterol 2019 Jan 29. Epub 2019 Jan 29.

Gastrointestinal Endoscopy Unit, University of Sao Paulo Medical School, Sao Paulo, Brazil.

Background: Per-oral endoscopic myotomy (POEM) has become the preferred alternative treatment to standard Heller myotomy for patients with esophageal achalasia, in Latin American countries. The aim of our study was to evaluate the efficacy and safety of a POEM in the management of achalasia with and without Chagas disease in patients receiving POEM.

Methods: Patients who underwent POEM from tertiary centers in Latin America were included in a dedicated registry. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001161DOI Listing
January 2019
3 Reads
3.498 Impact Factor

Cell death pathways in pathogenic trypanosomatids: lessons of (over)kill.

Cell Death Dis 2019 Jan 30;10(2):93. Epub 2019 Jan 30.

Laboratory of Cell Biology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Av. Brasil 4365, 21040-360, Manguinhos, Rio de Janeiro, Brazil.

Especially in tropical and developing countries, the clinically relevant protozoa Trypanosoma cruzi (Chagas disease), Trypanosoma brucei (sleeping sickness) and Leishmania species (leishmaniasis) stand out and infect millions of people worldwide leading to critical social-economic implications. Low-income populations are mainly affected by these three illnesses that are neglected by the pharmaceutical industry. Current anti-trypanosomatid drugs present variable efficacy with remarkable side effects that almost lead to treatment discontinuation, justifying a continuous search for alternative compounds that interfere with essential and specific parasite pathways. Read More

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http://dx.doi.org/10.1038/s41419-019-1370-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353990PMC
January 2019
1 Read

The remarkable pioneering contribution of Gaspar Vianna to the study of the neuropathology of Chagas disease.

Arq Neuropsiquiatr 2018 Dec;76(12):853-856

Universidade Federal de Minas Gerais, Faculdade de Medicina, Departamento de Anatomía Patológica e Medicina Legal, Belo Horizonte MG, Brasil.

Gaspar Vianna is considered one of the great names in Medicine and Science in Brazil. Yet, little prominence has been given to his studies in Neuropathology. He was the first to describe, in 1911, the histopathology and pathogenesis of chagasic encephalitis in the acute phase of Chagas disease, as well as the intracellular life cycle of Trypanosoma cruzi. Read More

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http://dx.doi.org/10.1590/0004-282X20180137DOI Listing
December 2018

Trends and predictors of non-communicable disease multimorbidity among adults living with HIV and receiving antiretroviral therapy in Brazil.

J Int AIDS Soc 2019 Jan;22(1):e25233

National Institute of Infectology - Evandro Chagas, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Introduction: People living with HIV (PLHIV) on antiretroviral therapy (ART) experience high rates of non-communicable diseases (NCDs). These co-morbidities often accumulate and older adults may suffer from multimorbidity. Multimorbidity has been associated with loss of quality of life, polypharmacy, and increased risk of frailty and mortality. Read More

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http://dx.doi.org/10.1002/jia2.25233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351749PMC
January 2019
2 Reads

Potential Utility of Protein Targets of Cysteine-S-Nitrosylation in Identifying Clinical Disease Status in Human Chagas Disease.

Front Microbiol 2018 15;9:3320. Epub 2019 Jan 15.

Institute for Human Infections and Immunity, University of Texas Medical Branch (UTMB), Galveston, TX, United States.

infection causes Chagas disease (ChD) presented by dilated cardiomyopathy and heart failure. During infection, oxidative and nitrosative stresses are elicited by the immune cells for control the pathogen; however, excess nitric oxide and superoxide production can result in cysteine S-nitrosylation (SNO) of host proteins that affects cellular homeostasis and may contribute to disease development. To identify the proteins with changes in SNO modification levels as a hallmark of ChD, we obtained peripheral blood mononuclear cells (PBMC) from seronegative, normal healthy (NH, = 30) subjects, and from seropositive clinically asymptomatic (ChD CA, = 25) or clinically symptomatic (ChD CS, = 28) ChD patients. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340995PMC
January 2019
2 Reads

Chagas and health promotion: dialogue inspired by the Curitiba Statement.

Health Promot Int 2019 Jan 23. Epub 2019 Jan 23.

Programme on Control of Chagas Disease, Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.

With the objective of providing an insightful analysis of Chagas disease in the world, the authors share their collective reflections about the current situation of this public health problem in: rural environments of Latin America; urban environments of endemic and non-endemic areas everywhere; and, at a global level. A perspective based on the 'Democracy and Health Promotion' axis allowed the development of an innovative update about Chagas disease as a model of a complex socio-environmental health problem, with a key set of elements that goes beyond biomedical aspects. The authors created a dialogue between the fundamental elements of the Curitiba Statement on Health Promotion and Equity and crucial aspects of a reflection on the reality of Chagas disease today that at the same time challenges the different actors involved. Read More

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http://dx.doi.org/10.1093/heapro/day105DOI Listing
January 2019

Prognosis and risk stratification in patients with decompensated heart failure receiving inotropic therapy.

Open Heart 2018 6;5(2):e000923. Epub 2018 Dec 6.

Internal Medicine Department, Centro Hospitalar de São João, Porto, Portugal.

Objectives: The prognostic significance of transient use of inotropes has been sufficiently studied in recent heart failure (HF) populations. We hypothesised that risk stratification in these patients could contribute to patient selection for advanced therapies.

Methods: We analysed a prospective cohort of adult patients admitted with decompensated HF and ejection fraction (left ventricular ejection fraction (LVEF)) less than 50%. Read More

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http://dx.doi.org/10.1136/openhrt-2018-000923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330199PMC
December 2018
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Effect of blockade of nitric oxide in heart tissue levels of Renin Angiotensin System components in acute experimental Chagas disease.

Life Sci 2019 Feb 23;219:336-342. Epub 2019 Jan 23.

Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, UFMG, Belo Horizonte, Minas Gerais, Brazil.

Chagas disease (CD) is an important cause of cardiomyopathy in South America. The pathophysiology of CD is still a matter of debate. Renin Angiotensin System (RAS) components are clearly involved in cardiovascular diseases. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.033DOI Listing
February 2019
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Dissecting a novel allosteric mechanism of cruzain: A computer-aided approach.

PLoS One 2019 25;14(1):e0211227. Epub 2019 Jan 25.

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.

Trypanosoma cruzi is the causative agent of Chagas disease, a neglected infection affecting millions of people in tropical regions. There are several chemotherapeutic agents for the treatment of this disease, but most of them are highly toxic and generate resistance. Currently, the development of allosteric inhibitors constitutes a promising research field, since it can improve the accessibility to more selective and less toxic medicines. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211227PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347273PMC
January 2019
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The Role of MIF on Eosinophil Biology and Eosinophilic Inflammation.

Clin Rev Allergy Immunol 2019 Jan 25. Epub 2019 Jan 25.

Laboratório de Bacteriologia e Imunologia Clínica, Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine that participates in innate and adaptive immune responses. MIF contributes to the resistance against infection agents, but also to the cellular and tissue damage in infectious, autoimmune, and allergic diseases. In the past years, several studies demonstrated a critical role for MIF in the pathogenesis of type-2-mediated inflammation, including allergy and helminth infection. Read More

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http://dx.doi.org/10.1007/s12016-019-08726-zDOI Listing
January 2019
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Miliary Tuberculosis in a Crohn's Disease Patient: The Risk beyond the Screening.

GE Port J Gastroenterol 2018 Dec 13;26(1):64-69. Epub 2018 Mar 13.

Gastroenterology Department of Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal.

Tumor necrosis factor alpha (TNFα) antagonist is recognized as an effective treatment to achieve clinical remission and healing mucosal in patients with moderate to severe active Crohn's disease. Considering that it plays a central role in immune-mediated modulation, there are some obvious concerns about its long-term safety. There is evidence that it may increase the risk of opportunistic infections such as tuberculosis, particularly reactivation of previous latent infection. Read More

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http://dx.doi.org/10.1159/000487297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341350PMC
December 2018
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Superiority of Interferon Gamma Assay Over Tuberculin Skin Test for Latent Tuberculosis in Inflammatory Bowel Disease Patients in Brazil.

Dig Dis Sci 2019 Jan 23. Epub 2019 Jan 23.

Department of Gastroenterology, The State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Background And Aims: To compare tuberculin skin test (TST) and interferon gamma release assay (IGRA) in the screening of LTBI among patients with inflammatory bowel disease (IBD) in an endemic area for tuberculosis, to evaluate the need for repeating tests during anti-TNFα, therapy, and to check whether the results may be affected by immunosuppression.

Methods: A cross-sectional study of 110 IBD patients and 64 controls was conducted in Rio de Janeiro, Brazil. The TST was administered after the Quantiferon()-TB Gold In-tube test was performed. Read More

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http://dx.doi.org/10.1007/s10620-019-5475-3DOI Listing
January 2019

First isolation of West Nile virus in Brazil.

Mem Inst Oswaldo Cruz 2019 Jan 17;114:e180332. Epub 2019 Jan 17.

Instituto Evandro Chagas, Seção de Arbovirologia e Febres Hemorrágicas, Ananindeua, PA, Brasil.

Background: Serological evidence of West Nile virus (WNV) infection has been reported in different regions of Brazil from equine and human hosts but the virus had never been isolated in the country.

Objectives: We sought to identify the viral etiology of equine encephalitis in Espírito Santo state.

Methods: We performed viral culture in C6/36 cells, molecular detection of WNV genome, histopathology and immunohistochemistry from horse cerebral tissue. Read More

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http://dx.doi.org/10.1590/0074-02760180332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343470PMC
January 2019
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Data on antigen recognition hindrance by antibodies covalently immobilized to Protein G magnetic beads by dimethyl pimelimidate (DMP) cross-linking.

Data Brief 2019 Feb 21;22:516-521. Epub 2018 Dec 21.

Laboratório de Biologia Celular, IOC, Fiocruz, Rio de Janeiro, RJ, Brazil.

The data presented herein is related to the article entitled " immunoproteome: calpain-like CAP5.5 differentially detected throughout distinct stages of human Chagas disease cardiomyopathy" [1]. Electrophoretic analyses under denaturing and reducing conditions indicate that covalent immobilization of human IgG to Protein G magnetic beads by cross-linking with 50 mM dimethyl pimelimidate hinders the recognition of antigens in immunoprecipitation assays. Read More

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http://dx.doi.org/10.1016/j.dib.2018.12.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327068PMC
February 2019

A pharmacokinetic-pharmacodynamic assessment of the hepatic and bone-marrow toxicities of the new trypanoside fexinidazole.

Antimicrob Agents Chemother 2019 Jan 22. Epub 2019 Jan 22.

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Thailand

Fexinidazole is a novel oral treatment for , human African trypanosomiasis: -HAT. Fexinidazole also has activity against the causative agent of Chagas disease. During the course of a dose ranging assessment in chronic indeterminate Chagas disease, delayed neutropenia and significant increases in hepatic transaminases were observed and clinical investigations were suspended. Read More

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http://dx.doi.org/10.1128/AAC.02515-18DOI Listing
January 2019
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Imidazole derivatives as promising agents for the treatment of Chagas disease.

Antimicrob Agents Chemother 2019 Jan 22. Epub 2019 Jan 22.

Centro de Investigaciones Biológicas (CSIC). Ramiro de Maeztu, 9, 28040 Madrid, Spain.

More than 100 years later after being firstly described, Chagas disease remains endemic in 21 Latin American countries and has spread to other continents. Indeed, this disease, caused by the protozoan parasite , is no longer just a problem for the American continent but has become a global health threat. Current therapies, nifurtimox and benznidazole (Bz), are far from being adequate due to undesirable effects and their lack of efficacy in the chronic phases of the disease. Read More

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http://aac.asm.org/lookup/doi/10.1128/AAC.02156-18
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http://dx.doi.org/10.1128/AAC.02156-18DOI Listing
January 2019
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Discovery and Genetic Validation of Chemotherapeutic Targets for Chagas' Disease.

Front Cell Infect Microbiol 2018 7;8:439. Epub 2019 Jan 7.

Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.

There is an urgent need to develop new treatments for Chagas' disease. To identify drug targets, it is important to understand the basic biology of , in particular with respect to the biological pathways or proteins that are essential for its survival within the host. This review provides a streamlined approach for identifying drug targets using freely available chemogenetic databases and outlines the relevant characteristics of an ideal chemotherapeutic target. Read More

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http://dx.doi.org/10.3389/fcimb.2018.00439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330712PMC
January 2019

Video-assisted thoracoscopic cardiac denervation of refractory ventricular arrhythmias and electrical storms: a single-center series.

J Cardiothorac Surg 2019 Jan 21;14(1):17. Epub 2019 Jan 21.

Department of Surgery, Universidad Nacional, Bogotá, Colombia.

Background: The combined treatment of beta-blockers with ablation and Implanted cardioverter defibrillation therapy, continues to be the mainstay treatment for ventricular arrhythmias (VAs). Despite treatment, some patients remain refractory.  Recent studies have shown success rates using video-assisted thoracoscopic (VATS) cardiac denervation as an effective therapeutic option for these patients. Read More

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http://dx.doi.org/10.1186/s13019-019-0838-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341718PMC
January 2019
1 Read