20,649 results match your criteria Chagas Disease American Trypanosomiasis


Cytotoxic and antiparasitic activities of diphosphine-metal complexes of group 10 containing acylthiourea as ligands.

J Inorg Biochem 2022 Jun 20;234:111906. Epub 2022 Jun 20.

Departamento de Química, Universidade Federal de São Carlos - UFSCar, 3561-901 São Carlos, SP, Brazil. Electronic address:

In this work, group 10 transition metal complexes bearing dppe [1,2-bis(diphenylphosphino)ethane] and acylthiourea ligands were evaluated for their cytotoxic and antiparasitic activities. Six new complexes with a general formula [M(L)(dppe)]BF [where M = Ni, Pd or Pt; L = N, N'-dimethyl-N-benzoyl thiourea (L) or N, N'-dimethyl-N-tiofenyl thiourea (L) were synthesized and characterized by infrared, NMR (P{H}, H and C{H}) spectroscopies, elemental analysis and molar conductivity. The structures of the complexes were confirmed by X-ray diffraction technique. Read More

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Immunologic Biomarkers in Peripheral Blood of Persons With Tuberculosis and Advanced HIV.

Front Immunol 2022 10;13:890003. Epub 2022 Jun 10.

Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

Introduction: Tuberculosis (TB) is a common opportunistic infection among people living with HIV. Diagnostic tests such as culture, Xpert-MTB-RIF, and ULTRA have low sensitivity in paucibacillary TB disease; a blood biomarker could improve TB diagnostic capabilities. We assessed soluble factors to identify biomarkers associated with TB among persons with advanced HIV. Read More

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Liver scaffolds obtained by decellularization: A transplant perspective in liver bioengineering.

J Tissue Eng 2022 Jan-Dec;13:20417314221105305. Epub 2022 Jun 20.

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.

Liver transplantation is the only definitive treatment for many diseases that affect this organ, however, its quantity and viability are reduced. The study of liver scaffolds based on an extracellular matrix is a tissue bioengineering strategy with great application in regenerative medicine. Collectively, recent studies suggest that liver scaffold transplantation may assist in reestablishing hepatic function in preclinical diseased animals, which represents a great potential for application as a treatment for patients with liver disease in the future. Read More

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Discrete typing units of Trypanosoma cruzi: Geographical and biological distribution in the Americas.

Sci Data 2022 Jun 24;9(1):360. Epub 2022 Jun 24.

Centro de Investigaciones en Microbiología y Biotecnología-UR (CIMBIUR), Facultad de Ciencias Naturales, Universidad del Rosario, Bogotá, Colombia.

Chagas disease caused by Trypanosoma cruzi is a public health issue in Latin America. This highly diverse parasite is divided into at least seven discrete typing units (DTUs) TcI-TcVI and Tcbat. Some DTUs have been associated with geographical distribution in epidemiological scenarios and clinical manifestations, but these aspects remain poorly understood. Read More

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Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and other inflammatory mediators in malaria by Plasmodium vivax during enteroparasites coinfection.

PLoS One 2022 24;17(6):e0270007. Epub 2022 Jun 24.

Programa de Pós-Graduação em Biologia Parasitária, Universidade Federal de Sergipe, São Cristóvão, Sergipe, Brasil.

Malaria is a major health issue with more than 200 million cases occurring annually. Moreover, in Malaria endemic area are frequently observed Malaria-enteroparasite co-infections associated with the modulation of inflammatory response. In this aspect, biomarkers play an important role in the disease prognosis. Read More

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Galectin-3 and fibrosis intensity in Chronic Chagas Cardiomyopathy: a systematic review.

Rev Inst Med Trop Sao Paulo 2022 24;64:e45. Epub 2022 Jun 24.

Universidade Federal de Minas Gerais, Faculdade de Medicina, Programa de Pós-Graduação em Ciências da Saúde: Medicina Tropical e Doenças Infecciosas, Belo Horizonte, Minas Gerais, Brazil.

Chronic Chagas Cardiomyopathy (CCC) is the most prevalent type of myocarditis and the main clinical form of the Chagas disease, which has peculiarities such as focal inflammation, structural derangement, hypertrophy, dilation, and intense reparative fibrosis. Many cellular compounds contribute to CCC development. Galectin-3 is a partaker in inflammation and contributes to myocardial fibrosis formation. Read More

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Genome plasticity driven by aneuploidy and loss of heterozygosity in .

Microb Genom 2022 Jun;8(6)

Centro de Investigaciones en Microbiología y Biotecnología-UR (CIMBIUR), Facultad de Ciencias Naturales, Universidad del Rosario, Bogotá, Colombia.

the causative agent of Chagas disease shows a marked genetic diversity and divided into at least six Discrete Typing Units (DTUs). High intra genetic variability has been observed in the TcI DTU, the most widely distributed DTU, where patterns of genomic diversity can provide information on ecological and evolutionary processes driving parasite population structure and genome organization. Chromosomal aneuploidies and rearrangements across multigene families represent an evidence of genome plasticity. Read More

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Human Neutrophils Present Mild Activation by Zika Virus But Reduce the Infection of Susceptible Cells.

Front Immunol 2022 7;13:784443. Epub 2022 Jun 7.

Laboratório de Virologia Molecular, Instituto Carlos Chagas, Fundação Oswaldo Cruz (FIOCRUZ), Curitiba, Brazil.

The emergence of the (ZIKV) has highlighted the need for a deeper understanding of virus-host interactions in order to pave the way for the development of antiviral therapies. The present work aimed to address the response of neutrophils during ZIKV infection. Neutrophils are important effector cells in innate immunity implicated in the host's response to neurotropic arboviruses. Read More

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Factors Involved in the Apoptotic Cell Death Mechanism in Yellow Fever Hepatitis.

Viruses 2022 Jun 1;14(6). Epub 2022 Jun 1.

Department of Pathology, State University of Para, Belem 66050-540, Brazil.

Yellow fever (YF), a non-contagious infectious disease, is endemic or enzootic to the tropical regions of the Americas and Africa. Periodic outbreaks or epidemics have a significant impact on public health. Programmed cell death, or apoptosis, is generally characterised by distinct morphological changes and energy-dependent biochemical pathways. Read More

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New Amino Naphthoquinone Derivatives as Anti- Agents Targeting Trypanothione Reductase.

Pharmaceutics 2022 May 25;14(6). Epub 2022 May 25.

Departamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Macul, Santiago 7820436, Chile.

To develop novel chemotherapeutic alternatives for the treatment of Chagas disease, in this study, a set of new amino naphthoquinone derivatives were synthesised and evaluated in vitro on the epimastigote and trypomastigote forms of strains (NINOA and INC-5) and on J774 murine macrophages. The design of the new naphthoquinone derivatives considered the incorporation of nitrogenous fragments with different substitution patterns present in compounds with activity on and, thus, 19 compounds were synthesised in a simple manner. Compounds and showed the lowest IC values (0. Read More

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In Silico, In Vitro, and Pharmacokinetic Studies of UBMC-4, a Potential Novel Compound for Treating against .

Pathogens 2022 May 24;11(6). Epub 2022 May 24.

PECET-Programa de Estudio y Control de Enfermedades Tropicales, School of Medicine, Universidad de Antioquia, Medellín 050010, Colombia.

The lack of therapeutic alternatives for the treatment of Chagas disease, a neglected disease, drives the discovery of new drugs with trypanocidal activity. Consequently, we conducted in vitro studies using UBMC-4, a potential AKT-like pleckstrin homology (PH) domain inhibitory compound found using bioinformatics tools. The half effective concentration (EC) on intracellular amastigotes was determined at 1. Read More

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Silver Nanoparticles Containing Fucoidan Synthesized by Green Method Have Anti- Activity.

Nanomaterials (Basel) 2022 Jun 15;12(12). Epub 2022 Jun 15.

Laboratório de Biotecnologia de Polímeros Naturais (BIOPOL), Departamento de Bioquímica, Centro de Biociências, Universidade Federal do Rio Grande do Norte (UFRN), Natal 59078-970, RN, Brazil.

The brown seaweed synthesizes three bioactive fucoidans, the most abundant of which is fucan A. This fucoidan was extracted and its identity was confirmed by chemical analysis, Fourier-transform infrared spectroscopy (FTIR), and agarose gel electrophoresis. Thereafter, silver nanoparticles containing fucan A (AgFuc) were produced using an environmentally friendly synthesis method. Read More

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Association of Functional Characteristics and Physiotherapy with COVID-19 Mortality in Intensive Care Unit in Inpatients with Cardiovascular Diseases.

Medicina (Kaunas) 2022 Jun 18;58(6). Epub 2022 Jun 18.

Postgraduate Program of Rehabilitation Sciences, Centro Universitário Augusto Motta/UNISUAM, Rio de Janeiro 20080-003, Brazil.

To estimate the association between admission functional outcomes and exposure to physiotherapy interventions with mortality rate in intensive care unit (ICU) inpatients with cardiovascular diseases and new coronavirus disease (COVID-19). : Retrospective cohort including 100 ICU inpatients (mean (standard deviation), age 75 (16) years) split into COVID-19+ or COVID-19-. The association of in-ICU death with admission functional outcomes and physiotherapy interventions was investigated using univariable and multivariable regression models. Read More

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Plasma Exosome-Derived microRNAs as Potential Diagnostic and Prognostic Biomarkers in Brazilian Pancreatic Cancer Patients.

Biomolecules 2022 May 31;12(6). Epub 2022 May 31.

Laboratory for Applied Science and Technology in Health, Carlos Chagas Institute, Oswaldo Cruz Foundation (Fiocruz), Curitiba 81310-020, Brazil.

Pancreatic cancer represents one of the leading causes of oncological death worldwide. A combination of pancreatic cancer aggressiveness and late diagnosis are key factors leading to a low survival rate and treatment inefficiency, and early diagnosis is pursued as a critical factor for pancreatic cancer. In this context, plasma microRNAs are emerging as promising players due to their non-invasive and practical usage in oncological diagnosis and prognosis. Read More

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Alboserpin, the Main Salivary Anticoagulant from the Disease Vector , Displays Anti-FXa-PAR Signaling In Vitro and In Vivo.

Immunohorizons 2022 Jun 23;6(6):373-383. Epub 2022 Jun 23.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD;

Blood-feeding arthropods secrete potent salivary molecules, which include platelet aggregation inhibitors, vasodilators, and anticoagulants. Among these molecules, Alboserpin, the major salivary anticoagulant from the mosquito vector , is a specific inhibitor of the human coagulation factor Xa (FXa). In this study, we investigated the anti-inflammatory properties of Alboserpin, in vitro and in vivo. Read More

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The Natural Alkaloid Tryptanthrin Induces Apoptosis-like Death in spp.

Trop Med Infect Dis 2022 Jun 20;7(6). Epub 2022 Jun 20.

Department of Natural Products and Food, School of Pharmacy, CCS, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.

Leishmaniasis is a vector-borne disease against which there are no approved vaccines, and the treatment is based on highly toxic drugs. The alkaloids consist of a chemical class of natural nitrogen-containing substances with a long history of antileishmanial activity. The present study aimed at determining the antileishmanial activity and in silico pharmacokinetic and toxicological potentials of tryptanthrin alkaloid. Read More

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Prevalence of Common Diseases in Indigenous People in Colombia.

Trop Med Infect Dis 2022 Jun 18;7(6). Epub 2022 Jun 18.

Medical Mission Institute, 97074 Würzburg, Germany.

The Indigenous tribe called the Wiwa lives retracted in the Sierra Nevada de Santa Marta, Colombia. Little is known about their health status and whether the health care system in place covers their needs. In 2017 and 2018, a permanent physician was in charge for the Wiwa. Read More

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The Sweet Side of Fungal Infections: Structural Glycan Diversity and Its Importance for Pathogenic Adaptation.

Medicines (Basel) 2022 Jun 16;9(6). Epub 2022 Jun 16.

Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, Brazil.

Fungal infections are the most common secondary infections in debilitated individuals in a state of chronic disease or immunosuppression. Despite this, most fungal infections are neglected, mainly due to the lower frequency of their more severe clinical forms in immunocompetent individuals with a healthy background. However, over the past few years, several cases of severe fungal infections in healthy individuals have provoked a change in the epidemiological dynamics of fungal infections around the world, both due to recurrent outbreaks in previously infrequent regions and the greater emergence of more pathogenic fungal variants affecting healthy individuals, such as in the genus. Read More

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Glycobiology of Cancer: Sugar Drives the Show.

Medicines (Basel) 2022 May 24;9(6). Epub 2022 May 24.

Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, Brazil.

Cancer development and progression is associated with aberrant changes in cellular glycosylation. Cells expressing altered glycan-structures are recognized by cells of the immune system, favoring the induction of inhibitory immune processes which subsequently promote tumor growth and spreading. Here, we discuss about the importance of glycobiology in modern medicine, taking into account the impact of altered glycan structures expressed in cancer cells as potential glycobiomarkers of disease, as well as on cancer development and progression. Read More

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Beyond Domestic Cats: Environmental Detection of DNA in a Hyperendemic Area of Sporotrichosis in Rio de Janeiro State, Brazil.

J Fungi (Basel) 2022 Jun 4;8(6). Epub 2022 Jun 4.

Laboratório de Micologia, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil.

In Brazil, sporotrichosis has transitioned from a rural to urban disease, driven by a shift in the initiation of infection from the accidental inoculation of organic matter to the traumatic implantation of the fungus by cats. Since the emergence of zoonotic sporotrichosis caused by , investigations have largely ignored the environmental habitat of the pathogen due to its association with domestic cats. Therefore, we investigated 18 environmental samples collected from rural areas of two cities where zoonotic sporotrichosis is endemic, but where domestic cats are scarce. Read More

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Expression of Is Epigenetically Regulated by DNA Methylation and Correlates with Immune Infiltrates in Clear-Cell Renal Cell Carcinoma.

Curr Issues Mol Biol 2022 May 25;44(6):2472-2489. Epub 2022 May 25.

Laboratory of Cytogenomics and Environmental Mutagenesis, Environment Section (SAMAM), Evandro Chagas Institute (IEC), BR 316, KM 7, s/n, Levilândia, Ananindeua 67030-000, PA, Brazil.

Clear cell renal cell carcinoma (KIRC) is the most common and highly malignant pathological type of kidney cancer, characterized by a profound metabolism dysregulation. As part of aspartate biosynthesis, mitochondrial (glutamic-oxaloacetic transaminase 2) is essential for regulating cellular energy production and biosynthesis, linking multiple pathways. Nevertheless, the expression profile and prognostic significance of in KIRC remain unclear. Read More

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[Native and non-native antigen to determine the seroprevalence of Trypanosoma cruzi in pregnant women from the state of Morelos, Mexico].

Rev Chilena Infectol 2022 02;39(1):45-52

Centro de Investigación sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México.

Background: Chagas disease is a globally important chronic systemic parasitic infection caused by Trypanosoma cruzi.

Aim: To determine the prevalence of antibodies against T cruzi in pregnant women from the state of Morelos, México.

Methods: 1,620 sera from pregnant women were analyzed using two serological tests: ELISAc (native crude antigen) and ELISAr (recombinant, non-native antigen). Read More

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February 2022

Preclinical advances and the immunophysiology of a new therapeutic chagas disease vaccine.

Expert Rev Vaccines 2022 Jun 23. Epub 2022 Jun 23.

Texas Children's Hospital Center for Vaccine Development, Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America.

Introduction: Chronic infection with the protozoal parasite leads to a progressive cardiac disease, known as chronic Chagasic cardiomyopathy (CCC). A new therapeutic Chagas disease vaccine is in development to augment existing antiparasitic chemotherapy drugs.

Areas Covered: We report on our current understanding of the underlying immunologic and physiologic mechanisms that lead to CCC, including parasite immune escape mechanisms that allow persistence and the subsequent inflammatory and fibrotic processes that lead to clinical disease. Read More

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Updated Estimates and Mapping for Prevalence of Chagas Disease among Adults, United States.

Emerg Infect Dis 2022 Jul;28(7):1313-1320

We combined American Community Survey data with age-specific Trypanosoma cruzi prevalence derived from US surveys and World Health Organization reports to yield estimates of Chagas disease in the United States, which we mapped at the local level. In addition, we used blood donor data to estimate the relative prevalence of autochthonous T. cruzi infection. Read More

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Contextual influence on poor self-rated health in patients with Chagas disease: multilevel study.

Cien Saude Colet 2022 Jul 26;27(7):2827-2842. Epub 2022 Feb 26.

Programa de Pós-Graduação em Ciências da Saúde, Universidade Estadual de Montes Claros. Av. Prof. Rui Braga s/n, Vila Mauriceia. 39401-089 Montes Claros MG Brasil.

Chagas disease (CD) is recognized by the World Health Organization as one of the thirteen most neglected tropical diseases in the world. Self-perceived health is considered a better predictor of mortality than objective measures of health status, and the context in which one lives influences this predictor. This study aimed to evaluate the prevalence and individual and contextual factors associated with poor self-rated health among CD patients from an endemic region in Brazil. Read More

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Chagas disease and social welfare: characterization of the disease in the Brazilian social security and social assistance, 2004-2016.

Epidemiol Serv Saude 2022 ;31(2):e2021777

Instituto Nacional do Seguro Social, Agência da Previdência Social de Uberlândia, Uberlândia, MG, Brasil.

Objective: To characterize the sociodemographic profile of beneficiaries of Brazilian social welfare affected by Chagas disease and identify factors associated with the granting of assistance benefits, 2004 to 2016.

Methods: Cross-sectional study based on secondary data from the Ministry of Labor and Social Security. Logistical regression was performed to estimate crude and adjusted odds ratios (OR) and 95% confidence intervals (95%CI). Read More

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Myocardial Injury in Patients With Acute and Subacute Chagas Disease in the Brazilian Amazon Using Cardiovascular Magnetic Resonance.

J Am Heart Assoc 2022 Jun 22:e021806. Epub 2022 Jun 22.

Programa de Pós-Graduação em Medicina Tropical-Universidade do Estado do Amazonas Manaus Amazonas Brazil.

Background Chagas disease is a neglected tropical disease that is still considered a global health emergency. In the Amazon region, most of the reports are of acute cases that are associated with oral transmission. This study aimed to evaluate myocardial injury in patients with acute Chagas disease before and after treatment. Read More

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Clinical Experience with Compression Taping to Treat Seroma After Breast Cancer Surgery: A Medical Device Clinical Study.

Adv Skin Wound Care 2022 Jul;35(7):1-6

At the National Cancer Institute, Rio de Janeiro, Brazil, Erica Alves Nogueira Fabro, MSc, PT, is Physical Therapist Manager, Physiotherapy Service, Cancer Hospital III; Clarice Gomes Chagas Teodózio, MSc, PT, is a PhD student, Oncology PhD Student Program; Rejane Medeiros Costa, PhD, PT, and Flávia Oliveira Macedo, MSc, PT, are Physical Therapists, Physiotherapy Service, Cancer Hospital III; Aline Cecilia Drumond Dutra Luz Machado Cardoso, BSc, and Raquel Barroso Evaldt Jacob, BSc, are nurses, Nursing Service, Cancer Hospital III; and Luiz Claudio Santos Thuler, MD, PhD, and Anke Bergmann, PhD, PT, are Researchers, Clinical Epidemiology Program. Acknowledgment: The authors thank Fisiovital (Indaiatuba, Sao Paolo, Brazil) for donating the Vitaltape bandage necessary for this research. The authors have disclosed no other financial relationships related to this article. Submitted May 19, 2021; accepted in revised form August 18, 2021.

Objective: To evaluate the safety of compressive taping in patients with seroma secondary to breast cancer surgery.

Methods: This study was a nonrandomized clinical study of medical devices applied to women indicated for seroma aspiration puncture after breast cancer surgery in a public reference hospital in Brazil. The intervention consisted of applying compressive taping over the seroma fluctuation area and maintained for 5 days. Read More

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Potential distributions of the parasite Trypanosoma cruzi and its vector Dipetalogaster maxima highlight areas at risk of Chagas disease transmission in Baja California Sur, Mexico, under climate change.

Med Vet Entomol 2022 Jun 20. Epub 2022 Jun 20.

Entomology Department, Faculty of Science, Ain Shams University, Cairo, Egypt.

Dipetalogaster maxima is a primary vector of Chagas disease in the Cape region of Baja California Sur, Mexico. The geographic distribution of D. maxima is limited to this small region of the Baja California Peninsula in Mexico. Read More

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Exhausted PD-1 TOX CD8 T Cells Arise Only in Long-Term Experimental Infection.

Front Immunol 2022 3;13:866179. Epub 2022 Jun 3.

Protozoa Immunology, Bernhard Nocht Institute of Tropical Medicine, Hamburg, Germany.

Infection with remains the most important neglected zoonosis in Latin America. This infection does not lead to specific symptoms in the acute phase, but chronic infection can result in Chagas disease (CD) with cardiac and/or gastrointestinal manifestations that can lead to death. CD8 T cells are highly effective and essential to control this infection, but fail to eliminate all parasites. Read More

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