17,237 results match your criteria Chagas Disease American Trypanosomiasis


Chagas disease as example of a reemerging parasite.

Semin Diagn Pathol 2019 Apr 17. Epub 2019 Apr 17.

Department of Pathology and Laboratory Medicine, Emory University, 1364 Clifton Rd, Atlanta, GA 30322, United States. Electronic address:

Trypanosoma cruzi, the protozoan that causes Chagas disease, is primarily transmitted by three main Triatomine vectors in endemic areas. However, the infection has become a potential emerging disease because the vector is found in non-endemic areas, there is migration of infected asymptomatic people that can infect the vector, become blood donors, or pass the disease vertically (congenital infections). Lastly, the disease can be acquired through contaminated food (oral transmission). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07402570193004
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http://dx.doi.org/10.1053/j.semdp.2019.04.008DOI Listing
April 2019
1 Read

Lithium ameliorates tubule-interstitial injury through activation of the mTORC2/protein kinase B pathway.

PLoS One 2019 19;14(4):e0215871. Epub 2019 Apr 19.

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Tubule-interstitial injury (TII) is a critical step in the progression of renal disease. It has been proposed that changes in proximal tubule (PT) albumin endocytosis plays an important role in the development of TII. Some reports have shown protective effects of lithium on kidney injury animal models that was correlated to proteinuria. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215871PLOS

Pomolic acid exhibits anticancer potential against a docetaxel‑resistant PC3 prostate cell line.

Oncol Rep 2019 Apr 19. Epub 2019 Apr 19.

Laboratory of Immunopathology, Institute of Biophysics Carlos Chagas Filho (IBCCF), Federal University of Rio de Janeiro, 21949‑900 Rio de Janeiro, RJ, Brazil.

Prostate cancer (PC) is one of the leading causes of cancer‑related death in the male population worldwide. Mortality of PC is dependent on tumor recurrence and its progression to metastatic disease. We examined the effects of pentacyclic triterpene pomolic acid (PA) on docetaxel‑resistant PC3 cells. Read More

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http://dx.doi.org/10.3892/or.2019.7132DOI Listing

Neutrophil properties in healthy and Leishmania infantum-naturally infected dogs.

Sci Rep 2019 Apr 18;9(1):6247. Epub 2019 Apr 18.

Laboratório de Imunobiologia das Leishmanioses, Departamento de Imunologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, 21941-970, Rio de Janeiro, RJ, Brazil.

Visceral leishmaniasis is a chronic disease that affects humans and dogs as well. Dogs, the domestic reservoir of Leishmania, play a central role in the transmission of visceral leishmaniasis, the most severe form of this disease. Neutrophils are the most abundant leukocytes in blood and interact with the parasite after infection. Read More

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http://www.nature.com/articles/s41598-019-42687-9
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http://dx.doi.org/10.1038/s41598-019-42687-9DOI Listing
April 2019
1 Read

Structure-activity relationship study of antitrypanosomal chalcone derivatives using multivariate analysis.

Bioorg Med Chem Lett 2019 Apr 12. Epub 2019 Apr 12.

Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, SP 09210-580, Brazil. Electronic address:

Chagas disease represents one of several neglected diseases with a reduced number of chemotherapeutical drugs including the highly toxic compounds benznidazole and nifurtimox. In this sense, natural products represent an import scaffold for the discovery of new biologically active compounds, in which chalcones are promising representatives due to their antitrypanosomal potential. In this work, a series of 36 chalcone derivatives were synthesized and tested against trypomastigotes of Trypanosoma cruzi. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X193024
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http://dx.doi.org/10.1016/j.bmcl.2019.04.020DOI Listing
April 2019
2 Reads

Differential proteomic comparison of breast cancer secretome using a quantitative paired analysis workflow.

BMC Cancer 2019 Apr 18;19(1):365. Epub 2019 Apr 18.

Laboratory of Toxinology, Oswaldo Cruz Institute, Fiocruz, Av. Brasil 4365, Manguinhos, Rio de Janeiro, 21040-360, Brazil.

Background: Worldwide, breast cancer is the main cause of cancer mortality in women. Most cases originate in mammary ductal cells that produce the nipple aspirate fluid (NAF). In cancer patients, this secretome contains proteins associated with the tumor microenvironment. Read More

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http://dx.doi.org/10.1186/s12885-019-5547-yDOI Listing

Detection of anti-Trypanosoma cruzi antibodies by chimeric antigens in chronic Chagas disease-individuals from endemic South American countries.

PLoS One 2019 18;14(4):e0215623. Epub 2019 Apr 18.

Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.

Background: Laboratory diagnosis of chronic Chagas disease is a troubling factor due to lack of reference tests. The WHO suggests the use of two distinct commercial serological tests in parallel. The performance of commercial immunoassays might fluctuate depending on the antigenic matrices and the local strains of T. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215623PLOS

The impairment in the NLRP3-induced NO secretion renders astrocytes highly permissive to T. cruzi replication.

J Leukoc Biol 2019 Apr 18. Epub 2019 Apr 18.

Departamento de Ciências Biológicas e Centro de Terapia Celular e Molecular (CTC-Mol), UNIFESP, São Paulo, Brazil.

Trypanossoma cruzi (T. cruzi), the causative protozoan of Chagas disease (CD) invades many cell types, including central nervous system (CNS) cells triggering local lesions and neurological impact. Previous work from our group described NLRP3 inflammasomes as central effectors for the parasite control by macrophages. Read More

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http://dx.doi.org/10.1002/JLB.4AB1118-416RRDOI Listing

-Nitrosulfonamides as Carbonic Anhydrase Inhibitors: A Promising Chemotype for Targeting Chagas Disease and Leishmaniasis.

ACS Med Chem Lett 2019 Apr 27;10(4):413-418. Epub 2018 Nov 27.

Department of NEUROFARBA, Pharmaceutical and Nutraceutical Section, University of Florence, Via U. Schiff 6, 50019 Sesto Fiorentino (Firenze), Italy.

and Leishmania spp. are protozoa of the Trypanosomatidae family, respectively, responsible of the neglected tropical disorders (NTDs) Chagas disease and leishmaniasis. The present pharmacotherapy is often ineffective and exhibits serious side effects. Read More

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http://dx.doi.org/10.1021/acsmedchemlett.8b00430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466549PMC

Human collectin-11 (COLEC11) and its synergic genetic interaction with MASP2 are associated with the pathophysiology of Chagas Disease.

PLoS Negl Trop Dis 2019 Apr 17;13(4):e0007324. Epub 2019 Apr 17.

Laboratory of Molecular Immunopathology, Department of Clinical Pathology, Federal University of Paraná, Curitiba, Brazil.

Chagas Disease (CD) is an anthropozoonosis caused by Trypanosoma cruzi. With complex pathophysiology and variable clinical presentation, CD outcome can be influenced by parasite persistence and the host immune response. Complement activation is one of the primary defense mechanisms against pathogens, which can be initiated via pathogen recognition by pattern recognition molecules (PRMs). Read More

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http://dx.plos.org/10.1371/journal.pntd.0007324
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http://dx.doi.org/10.1371/journal.pntd.0007324DOI Listing
April 2019
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Daily Variations in the Expression of Genes Related to Insecticide Resistance in the Chagas Disease Vector (Hemiptera: Reduviidae).

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

Instituto de Investigaciones en Ciencias de la Salud (INICSA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.

Pyrethroid resistance has been detected in , which in part has been attributed to increased oxidative metabolism of the insecticide by cytochrome P450s. Nicotinamide adenine dinucleotide phosphate (NADPH) cytochrome P450 reductase (CPR) catalyzes electron transfer from NADPH to all known cytochrome P450s. In this study, the expression of the gene at transcriptional level was determined in different tissues and two life stages. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0155DOI Listing

Chemical Constituents of as Inhibitors of Sirtuins.

Molecules 2019 Apr 3;24(7). Epub 2019 Apr 3.

Instituto Gonçalo Moniz, FIOCRUZ, Salvador, BA 40296-710, Brazil.

Benznidazole and nifurtimox, the only drugs available for the treatment of Chagas disease, have limited efficacy and have been associated with severe adverse side effects. Thus, there is an urgent need to find new biotargets for the identification of novel bioactive compounds against the parasite and with low toxicity. Silent information regulator 2 (Sir2) enzymes, or sirtuins, have emerged as attractive targets for the development of novel antitrypanosomatid agents. Read More

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http://dx.doi.org/10.3390/molecules24071299DOI Listing

Role of Aryl Hydrocarbon Receptor (AhR) in the Regulation of Immunity and Immunopathology During Infection.

Front Immunol 2019 29;10:631. Epub 2019 Mar 29.

Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.

Resistance to infection is dependent on a rapid induction of Th1-type and CD8+ T cell responses that should be promptly balanced to prevent immunopathology. -infected B6 mice are able to control parasite replication but show a limited expansion of Foxp3+regulatory T (Treg) cells that results in the accumulation of effector immune cells and the development of acute liver pathology. AhR is a ligand-activated transcription factor that promotes Treg cell development and suppression of pro-inflammatory cytokine production in dendritic cells, altering the course of adaptive immune response and the development of immunopathology. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450169PMC

Identification of -Glcnacylated Proteins in .

Front Endocrinol (Lausanne) 2019 29;10:199. Epub 2019 Mar 29.

Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.

Originally an anthropozoonosis in the Americas, Chagas disease has spread from its previous borders through migration. It is caused by the protozoan . Differences in disease severity have been attributed to a natural pleomorphism in . Read More

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http://dx.doi.org/10.3389/fendo.2019.00199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449728PMC

Guidelines for the diagnosis and treatment of Chagas disease.

Lancet 2019 Apr;393(10180):1486-1487

Fundación Mundo Sano, C1061ABC Buenos Aires, Argentina. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01406736193028
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http://dx.doi.org/10.1016/S0140-6736(19)30288-0DOI Listing
April 2019
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An oral dose of Fluralaner administered to dogs kills pyrethroid-resistant and susceptible Chagas disease vectors for at least four months.

Vet Parasitol 2019 Apr 18;268:98-104. Epub 2019 Mar 18.

Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Laboratory of Eco-Epidemiology, Ciudad Universitaria, C1428EHA, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas-Universidad de Buenos Aires, Instituto de Ecología, Genética y Evolución de Buenos Aires (IEGEBA), Ciudad Universitaria, C1428EHA, Buenos Aires, Argentina.

New vector control tools that can fit into a broader integrated vector management strategy are notably lacking. We conducted a seven-month randomized trial to assess the efficacy of a single oral dose of Fluralaner (Bravecto) administered to dogs on the blood-feeding success, engorgement levels and mortality of pyrethroid-resistant and -susceptible Triatoma infestans third- and fifth-instar nymphs. The trial included 10 Fluralaner-treated and 10 placebo-treated (control) outbred healthy dogs residing in rural houses of the Argentine Chaco. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03044017193006
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http://dx.doi.org/10.1016/j.vetpar.2019.03.005DOI Listing
April 2019
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Cytosolic Fe-superoxide dismutase safeguards from macrophage-derived superoxide radical.

Proc Natl Acad Sci U S A 2019 Apr 12. Epub 2019 Apr 12.

Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, 11800 Montevideo, Uruguay;

, the causative agent of Chagas disease (CD), contains exclusively Fe-dependent superoxide dismutases (Fe-SODs). During invasion to macrophages, superoxide radical (O) is produced at the phagosomal compartment toward the internalized parasite via NOX-2 (gp91-) activation. In this work, cytosolic Fe-SODB overexpressers (pRIBOTEX-Fe-SODB) exhibited higher resistance to macrophage-dependent killing and enhanced intracellular proliferation compared with wild-type (WT) parasites. Read More

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http://dx.doi.org/10.1073/pnas.1821487116DOI Listing
April 2019
2 Reads

Dose-response evaluation of a copaiba-containing varnish against streptococcus mutans in vivo.

Saudi Pharm J 2019 Mar 15;27(3):363-367. Epub 2018 Dec 15.

Postgraduate Program in Drug Development, School of Pharmacy, Federal University of Ceará, Brazil.

Introduction: Dental caries is the most prevalent disease in humans and its incidence is particularly high during childhood. The use of medicinal plants is a common practice in Brazil.

Objective: To evaluate the optimal antimicrobial concentration of (copaiba) oil-resin, in the form of dental varnish, against () in children. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13190164183058
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http://dx.doi.org/10.1016/j.jsps.2018.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438705PMC
March 2019
1 Read

Neonatal infection leads to increased susceptibility to Aβ oligomer-induced brain inflammation, synapse loss and cognitive impairment in mice.

Cell Death Dis 2019 Apr 11;10(4):323. Epub 2019 Apr 11.

School of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21944-590, Brazil.

Harmful environmental stimuli during critical stages of development can profoundly affect behavior and susceptibility to diseases. Alzheimer disease (AD) is the most frequent neurodegenerative disease, and evidence suggest that inflammatory conditions act cumulatively, contributing to disease onset. Here we investigated whether infection early in life can contribute to synapse damage and cognitive impairment induced by amyloid-β oligomers (AβOs), neurotoxins found in AD brains. Read More

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http://dx.doi.org/10.1038/s41419-019-1529-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459845PMC
April 2019
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Neem oil increases the persistence of the entomopathogenic fungus Metarhizium anisopliae for the control of Aedes aegypti (Diptera: Culicidae) larvae.

Parasit Vectors 2019 Apr 11;12(1):163. Epub 2019 Apr 11.

Department of Entomology and Plant Pathology, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, CEP 28013-602, Brazil.

Background: The entomopathogenic fungus Metarhizium anisopliae is a candidate for the integrated management of the disease vector mosquito Aedes aegypti. Metarhizium anisopliae is pathogenic and virulent against Ae. aegypti larvae; however, its half-life is short without employing adjuvants. Read More

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http://dx.doi.org/10.1186/s13071-019-3415-xDOI Listing

Severe infection increases cardiovascular risk among HIV-infected individuals.

BMC Infect Dis 2019 Apr 11;19(1):319. Epub 2019 Apr 11.

Laboratório de Pesquisa Clínica em Medicina Intensiva, Instituto Nacional de Infectologia Evandro Chagas (INI), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.

Background: The identification and management of cardiovascular risk factors became a major clinical issue among HIV-infected individuals in the post-cART era. As in the past decades the link between acute infections and cardiovascular diseases became clear in the general population, we sorted to investigate the role of severe infections on incident cardiovascular diseases (CVDs) among HIV-infected individuals.

Methods: HIV-infected individuals aged ≥18 years, with no history of CVD were followed from January 2000 to December 2013 until the occurrence of the first CVD event, death or end of study, whichever occurred first. Read More

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http://dx.doi.org/10.1186/s12879-019-3894-6DOI Listing

Propofol for sedation for direct current cardioversion.

Ann Card Anaesth 2019 Apr-Jun;22(2):113-121

Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Direct current cardioversion is a low-risk and standard procedure to restore normal sinus rhythm in patients with tachyarrhythmias. It requires sedation to facilitate the procedure, as it is painful and distressful. The preferred anesthetic drug must be short acting, producing conscious sedation, to enable rapid recovery after the procedure. Read More

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http://dx.doi.org/10.4103/aca.ACA_72_18DOI Listing
April 2019
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Structure-Based Virtual Screening and In Vitro Evaluation of New Cruzain Inhibitors.

Int J Mol Sci 2019 Apr 9;20(7). Epub 2019 Apr 9.

Laboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.

Chagas disease (CD), or American trypanosomiasis, causes more than 10,000 deaths per year in the Americas. Current medical therapy for CD has low efficacy in the chronic phase of the disease and serious adverse effects; therefore, it is necessary to search for new pharmacological treatments. In this work, the ZINC database was filtered using the -acylhydrazone moiety and a subsequent structure-based virtual screening was performed using the cruzain enzyme of to predict new potential cruzain inhibitors. Read More

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http://dx.doi.org/10.3390/ijms20071742DOI Listing
April 2019
2.862 Impact Factor

Conserved motifs in nuclear genes encoding predicted mitochondrial proteins in Trypanosoma cruzi.

PLoS One 2019 9;14(4):e0215160. Epub 2019 Apr 9.

Laboratorio de Interacciones Moleculares, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay.

Trypanosoma cruzi, the protozoan parasite that causes Chagas' disease, exhibits peculiar biological features. Among them, the presence of a unique mitochondrion is remarkable. Even though the mitochondrial DNA constitutes up to 25% of total cellular DNA, the structure and functionality of the mitochondrion are dependent on the expression of the nuclear genome. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215160PLOS

Estimating the current burden of Chagas disease in Mexico: A systematic review and meta-analysis of epidemiological surveys from 2006 to 2017.

PLoS Negl Trop Dis 2019 04 9;13(4):e0006859. Epub 2019 Apr 9.

Department of Tropical Medicine, School of Public Health and Tropical Medicine, and Vector-Borne and Infectious Disease Research Center, Tulane University, 1440 Canal St., New Orleans, LA 70112, United States of America.

Background: In Mexico, estimates of Chagas disease prevalence and burden vary widely. Updating surveillance data is therefore an important priority to ensure that Chagas disease does not remain a barrier to the development of Mexico's most vulnerable populations.

Methodology/principal Findings: The aim of this systematic review and meta-analysis was to analyze the literature on epidemiological surveys to estimate Chagas disease prevalence and burden in Mexico, during the period 2006 to 2017. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006859DOI Listing
April 2019
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Developments on treatment of Chagas disease - from discovery to current times.

Eur Rev Med Pharmacol Sci 2019 Mar;23(6):2576-2586

Universidade Federal Fluminense, Instituto de Química, Departamento de Química Orgânica, Programa de Pós-Graduação em Química, Rio de Janeiro, Brazil.

Objective: This work aims to collect publications of available drugs for reposition and new substance development against the Chagas disease, since they represent the beginning of a path for new discoveries of viable alternatives to improve the prognosis of millions of patients around the world.

Patients And Methods: An extended research on English and Portuguese-language literature in the Scientific Electronic Library Online - Scielo, SciFinder and PubMed - database was made. The bibliography was screened using the keywords "Chagas Disease" and "Treatment". Read More

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http://www.europeanreview.org/article/17407
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http://dx.doi.org/10.26355/eurrev_201903_17407DOI Listing
March 2019
3 Reads

Synergic effect of allopurinol in combination with nitro-heterocyclic compounds against .

Antimicrob Agents Chemother 2019 Apr 8. Epub 2019 Apr 8.

Laboratório de Doenças Parasitárias, Escola de Medicina & Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto, Campus Universitário Morro do Cruzeiro, Ouro Preto, MG, 35400-000, Brazil.

Combination therapy has gained attention as a possible strategy for overcoming the limitations of the present therapeutic arsenal for Chagas disease. The aim of this study was to evaluate the effect of allopurinol in association with nitro-heterocyclic compounds on infection with the Y strain of The effect of allopurinol plus benznidazole or nifurtimox on intracellular amastigotes in H9c2 infected cells was assessed in a 72 h assay. The interactions were classified as synergic for both allopurinol/nifurtimox (sums of fractional inhibitory concentrations - ∑FICs = 0. Read More

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http://dx.doi.org/10.1128/AAC.02264-18DOI Listing
April 2019
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Trypanosoma cruzi infection, discrete typing units and feeding sources among Psammolestes arthuri (Reduviidae: Triatominae) collected in eastern Colombia.

Parasit Vectors 2019 Apr 8;12(1):157. Epub 2019 Apr 8.

Grupo de Investigaciones Microbiológicas-UR (GIMUR), Programa de Biología, Facultad de Ciencias Naturales y Matemáticas, Universidad del Rosario, Bogotá, Colombia.

Background: Chagas disease (CD) is caused by the protozoan parasite Trypanosoma cruzi, and is transmitted by hematophagous insects of the family Reduviidae. Psammolestes arthuri is a sylvatic triatomine distributed in Colombia and Venezuela which feeds on birds and there are a few studies that have reported Ps. arthuri naturally infected with T. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-019-3422-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454608PMC
April 2019
3 Reads

Acute kidney injury overview: From basic findings to new prevention and therapy strategies.

Pharmacol Ther 2019 Apr 6. Epub 2019 Apr 6.

Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho 373, Bloco J, sala 26, Rio de Janeiro, RJ 21941-902, Brazil. Electronic address:

Acute kidney injury (AKI) is defined as a decrease in kidney function within hours, which encompasses both injury and impairment of renal function. AKI is not considered a pathological condition of single organ failure, but a syndrome in which the kidney plays an active role in the progression of multi-organ dysfunction. The incidence rate of AKI is increasing and becoming a common (8-16% of hospital admissions) and serious disease (four-fold increased hospital mortality) affecting public health costs worldwide. Read More

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http://dx.doi.org/10.1016/j.pharmthera.2019.04.001DOI Listing
April 2019
1 Read

Insights into Chagas treatment based on the potential of bacteriocin AS-48.

Int J Parasitol Drugs Drug Resist 2019 Mar 29;10:1-8. Epub 2019 Mar 29.

Department of Parasitology, Instituto de Investigación Biosanitaria (ibs.Granada), Hospitales Universitarios De Granada/University of Granada, Severo Ochoa S/n, E-18071, Granada, Spain. Electronic address:

Chagas disease caused by the protozoan parasite Trypanosoma cruzi represents a significant public health problem in Latin America, affecting around 8 million cases worldwide. Nowadays is urgent the identification of new antichagasic agents as the only therapeutic options available, Nifurtimox and Benznidazole, are in use for >40 years, and present high toxicity, limited efficacy and frequent treatment failures in the chronic phase of the disease. Recently, it has been described the antiparasitic effect of AS-48, a bacteriocin produced by Enterococcus faecalis, against Trypanosoma brucei and Leishmania spp. Read More

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http://dx.doi.org/10.1016/j.ijpddr.2019.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447751PMC
March 2019
2 Reads

Survivorship of wild caught Mepraia spinolai nymphs: The effect of seasonality and Trypanosoma cruzi infection after feeding and fasting in the laboratory.

Infect Genet Evol 2019 Apr 3;71:197-204. Epub 2019 Apr 3.

Program of Cellular and Molecular Biology, ICBM, Faculty of Medicine, University of Chile, Chile. Electronic address:

Chagas disease is caused by Trypanosoma cruzi. Vector survival is an important variable affecting vectorial capacity to determine parasite transmission risk. The aims of this study are to evaluate vector survival under fasting/starvation conditions of wild-caught Mepraia spinolai after feeding and fasting, the pathogenicity of T. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.04.002DOI Listing

Omentum acts as a regulatory organ controlling skeletal muscle repair of mdx mice diaphragm.

Cell Tissue Res 2019 Apr 5. Epub 2019 Apr 5.

Departamento de Imunobiologia, Instituto de Biologia, Universidade Federal Fluminense, Niterói, Rio de Janeiro, 24020-141, Brazil.

Duchenne muscular dystrophy is a lethal X-linked muscle wasting disease due to mutations of the dystrophin gene leading to distinct susceptibility to degeneration and fibrosis among skeletal muscles. This study aims at verifying whether intense mdx diaphragm remodeling could be attributed to influences from the omentum, a lymphohematopoietic tissue rich in progenitor cells and trophic factors. Mdx omentum produces growth factors HGF and FGF and increased amounts of VEGF with pleiotropic actions upon muscular progenitors and myoblast differentiation. Read More

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http://dx.doi.org/10.1007/s00441-019-03012-yDOI Listing
April 2019
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Leishmaniasis and Chagas Disease - Neglected Tropical Diseases: Treatment Updates.

Curr Top Med Chem 2019 ;19(3):174-177

Laboratorio de Estudos Avancados de Microrganismos Emergentes e Resistentes, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Goes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

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http://dx.doi.org/10.2174/156802661903190328155136DOI Listing
January 2019

Omega-3 fatty acid supplementation can prevent changes in mitochondrial energy metabolism and oxidative stress caused by chronic administration of L-tyrosine in the brain of rats.

Metab Brain Dis 2019 Apr 4. Epub 2019 Apr 4.

Laboratório de Bioenergética, Programa de Pós-graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, SC, Brazil.

Deficiency of hepatic enzyme tyrosine aminotransferase characterizes the innate error of autosomal recessive disease Tyrosinemia Type II. Patients may develop neurological and developmental difficulties due to high levels of the amino acid tyrosine in the body. Mechanisms underlying the neurological dysfunction in patients are poorly known. Read More

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http://dx.doi.org/10.1007/s11011-019-00411-6DOI Listing
April 2019
1 Read

Zika Virus Impairs Neurogenesis and Synaptogenesis Pathways in Human Neural Stem Cells and Neurons.

Front Cell Neurosci 2019 15;13:64. Epub 2019 Mar 15.

Department of Parasitology, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil.

Growing evidences have associated Zika virus (ZIKV) infection with congenital malformations, including microcephaly. Nonetheless, signaling mechanisms that promote the disease outcome are far from being understood, affecting the development of suitable therapeutics. In this study, we applied shotgun mass spectrometry (MS)-based proteomics combined with cell biology approaches to characterize altered molecular pathways on human neuroprogenitor cells (NPC) and neurons derived from induced pluripotent stem cells infected by ZIKV-BR strain, obtained from the 2015 Brazilian outbreak. Read More

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http://dx.doi.org/10.3389/fncel.2019.00064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436085PMC
March 2019
1 Read

Screening strategy for Chagas disease in a non-endemic country (Switzerland): a prospective evaluation.

Swiss Med Wkly 2019 Mar 4;149:w20050. Epub 2019 Apr 4.

Department of Ambulatory Care and Community Medicine, University Hospital of Lausanne, Switzerland / Swiss Tropical and Public Health Institute, University of Basel, Switzerland.

The WHO recommends screening of Latin American migrants for Chagas disease to reduce morbidity and mortality and increase the likelihood of eradicating the disease. The objective was to assess the feasibility and acceptability of a screening strategy in one Swiss canton. From February 2011 to September 2012, people attending six healthcare centres of different types were offered a rapid diagnostic test if they or their mother were of Latin American origin (or, at the blood donation centre, if they had travelled for ≥1 year in Latin America). Read More

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http://dx.doi.org/10.4414/smw.2019.20050DOI Listing
March 2019
1 Read

Glucuronoxylomannan and Sterylglucoside Are Required for Host Protection in an Animal Vaccination Model.

MBio 2019 04 2;10(2). Epub 2019 Apr 2.

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA

is an encapsulated fungal pathogen that causes meningoencephalitis. There are no prophylactic tools for cryptococcosis. Previously, our group showed that a mutant lacking the gene encoding sterylglucosidase (Δ) induced protection in both immunocompetent and immunocompromised murine models of cryptococcosis. Read More

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http://dx.doi.org/10.1128/mBio.02909-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445945PMC
April 2019
3 Reads

Analysis of the antiparasitic and anticancer activity of the coconut palm (Cocos nucifera L. ARECACEAE) from the natural reserve of Punta Patiño, Darién.

PLoS One 2019 2;14(4):e0214193. Epub 2019 Apr 2.

Centro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), City of Knowledge, Apartado, Panama, Republic of Panama.

Cocos nucifera (C. nucifera) (the coconut palm tree) has been traditionally used to fight a number of human diseases, but only a few studies have tested its components against parasites such as those that cause malaria. In this study, C. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214193PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445518PMC
April 2019
3 Reads

Does Progressive Introduction of Benznidazole Reduce the Chance of Adverse Events in the Treatment of Chagas Disease?

Am J Trop Med Hyg 2019 Apr 1. Epub 2019 Apr 1.

Internal Medicine Department, Hospital Universitario 12 de Octubre, Madrid, Spain.

In this retrospective cohort study, we aimed to assess whether introducing benznidazole at escalating doses reduces the probability of adverse events or treatment discontinuation compared with a full-dose scheme. We collected data from patients who had chronic infection and underwent treatment from July 2008 to January 2017 in a referral center in Madrid. Dose was adjusted to body weight (5 mg/kg/day), with treatment introduction with full dose or escalating dose according to local consensus and protocols. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0638DOI Listing
April 2019
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Low-level Parasite Persistence Drives Vasculitis and Myositis in Skeletal Muscle of Mice Chronically-infected with.

Infect Immun 2019 Apr 1. Epub 2019 Apr 1.

Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, Maryland, United States of America.

In chronic () infection, the cause of Chagas disease, life-threatening inflammatory diseases develop over time in the heart, esophagus, and colon of some patients. C57BL/6 mice infected with the myotropic strain of model many of the immunologic and parasitologic features of the human infection but succumb to chronic paralyzing myositis and skeletal muscle vasculitis, not cardiomyopathy or gastrointestinal disease. Here we show that T cell depletion in the chronic phase of this model increased tissue parasitism to acute phase levels, and induced neutrophilic skeletal muscle inflammation. Read More

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http://dx.doi.org/10.1128/IAI.00081-19DOI Listing

Glucose-6-Phosphate Dehydrogenase from the Human Pathogen Trypanosoma cruzi Evolved Unique Structural Features to Support Efficient Product Formation.

J Mol Biol 2019 Mar 28. Epub 2019 Mar 28.

Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Mataojo 2020, 11400-, Montevideo, Uruguay. Electronic address:

Glucose-6-phosphate dehydrogenase (G6PDH) is the key enzyme supplying reducing power (NADPH) to the cells, by oxidation of glucose-6-phosphate (G6P), and in the process providing a precursor of ribose-5-phosphate. G6PDH is also a virulence factor of pathogenic trypanosomatid parasites. To uncover the biochemical and structural features that distinguish TcG6PDH from its human homolog, we have now solved the crystal structures of the G6PDH from Trypanosoma cruzi (TcG6PDH), alone and in complex with G6P. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00222836183069
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http://dx.doi.org/10.1016/j.jmb.2019.03.023DOI Listing
March 2019
3 Reads

Activity of Estafietin and Analogues on and .

Molecules 2019 Mar 28;24(7). Epub 2019 Mar 28.

CONICET-Universidad Nacional de Tucumán, Instituto de Química del Noroeste-CONICET (INQUINOA), Ayacucho 471, San Miguel de Tucumán T4000INI, Argentina.

Sesquiterpene lactones are naturally occurring compounds mainly found in the Asteraceae family. These types of plant metabolites display a wide range of biological activities, including antiprotozoal activity and are considered interesting structures for drug discovery. Four derivatives were synthesized from estafietin (), isolated from (Asteraceae): 11βH,13-dihydroestafietin (), epoxyestafietin ( and ), 11βH,13-methoxyestafietin, () and 11βH,13-cianoestafietin. Read More

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http://dx.doi.org/10.3390/molecules24071209DOI Listing

Congenital Zika Syndrome: is the heart part of its spectrum?

Clin Microbiol Infect 2019 Mar 25. Epub 2019 Mar 25.

Cardiovascular Research Unit, National Institute of Cardiology, Rio de Janeiro, Brazil.

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http://dx.doi.org/10.1016/j.cmi.2019.03.020DOI Listing

The limpet transcription factors of Triatoma infestans regulate the response to fungal infection and modulate the expression pattern of defensin genes.

Insect Biochem Mol Biol 2019 May 26;108:53-60. Epub 2019 Mar 26.

Instituto de Investigaciones Bioquímicas de La Plata (CONICET CCT La Plata-UNLP), Universidad Nacional de La Plata, Argentina. Electronic address:

As part of the innate humoral response to microbial attack, insects activate the expression of antimicrobial peptides (AMP). Understanding the regulatory mechanisms of this response in the Chagas disease vector Triatoma infestans is important since biological control strategies against pyrethroid-resistant insect populations were recently addressed by using the entomopathogenic fungus Beauveria bassiana. By bioinformatics, gene expression, and silencing techniques in T. Read More

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http://dx.doi.org/10.1016/j.ibmb.2019.03.010DOI Listing

Willingness to Take Multidrug-Resistant Tuberculosis (MDR-TB) Preventive Therapy among Adult and Adolescent Household Contacts of MDR-TB Index Cases: An International Multi-Site Cross-Sectional Study.

Clin Infect Dis 2019 Mar 28. Epub 2019 Mar 28.

Centers for Disease Control and Prevention, Atlanta, GA, USA.

Background: Household contacts (HHCs) of individuals with multidrug-resistant tuberculosis (MDR-TB) are at high risk of infection and subsequent disease. There is limited evidence on the willingness of MDR-TB HHCs to take MDR-TB preventive therapy (TPT) to decrease their risk of TB disease.

Methods: In this cross-sectional study of HHCs of MDR and rifampicin resistant (RR)-TB index cases from 16 clinical research sites in eight countries, enrollees were interviewed to assess willingness to take a hypothetical, newly-developed MDR TPT if offered. Read More

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http://dx.doi.org/10.1093/cid/ciz254DOI Listing
March 2019
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A review on the occurrence of companion vector-borne diseases in pet animals in Latin America.

Parasit Vectors 2019 Mar 28;12(1):145. Epub 2019 Mar 28.

Institute of Parasitology, Faculty of Veterinary Medicine, Leipzig University, Leipzig, Germany.

Companion vector-borne diseases (CVBDs) are an important threat for pet life, but may also have an impact on human health, due to their often zoonotic character. The importance and awareness of CVBDs continuously increased during the last years. However, information on their occurrence is often limited in several parts of the world, which are often especially affected. Read More

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http://dx.doi.org/10.1186/s13071-019-3407-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438007PMC
March 2019
1 Read

Development of a Social Network-Based Intervention to Overcome Multilevel Barriers to ART Adherence Among Adolescents in Brazil.

AIDS Educ Prev 2019 Apr;31(2):111-126

Brown University School of Public Health, Providence, Rhode Island.

Brazil's comprehensive HIV treatment program does not specifically address ART adherence challenges for adolescents-a group accounting for the largest number of incident HIV infections in Brazil. We conducted three focus groups with 24 adolescents (age 15-24) living with HIV in Rio de Janeiro, separately for cisgender men who have sex with men, heterosexual-identified cisgender men and women, and transgender women of any sexual orientation, and key informant interviews (n = 7) with infectious disease specialists and HIV/AIDS service organization staff. Content analysis identified socioecological barriers and facilitators to adherence, including individual (e. Read More

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http://dx.doi.org/10.1521/aeap.2019.31.2.111DOI Listing
April 2019
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Cardiac Evaluation in the Acute Phase of Chagas' Disease with Post-Treatment Evolution in Patients Attended in the State of Amazonas, Brazil.

Arq Bras Cardiol 2019 Mar 7;112(3):240-246. Epub 2019 Jan 7.

Universidade do Estado do Amazonas, Manaus, AM - Brazil.

Background: In the past two decades, a new epidemiological profile of Chagas' disease (CD) has been registered in the Brazilian Amazon where oral transmission has been indicated as responsible for the increase of acute cases. In the Amazonas state, five outbreaks of acute CD have been registered since 2004. The cardiac manifestations in these cases may be characterized by diffuse myocarditis, with alteration in the electrocardiogram (ECG) and transthoracic echocardiogram (TTE). Read More

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http://dx.doi.org/10.5935/abc.20190007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424035PMC
March 2019
2 Reads

An Approach to The Acute Phase of Chagas' Disease: The Continuing Challenge it Presents in the 21(st) Century.

Arq Bras Cardiol 2019 Mar;112(3):247-248

Universidade de Pernambuco - Cardiologia, Recife, PE - Brazil.

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http://dx.doi.org/10.5935/abc.20190035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424032PMC