21,799 results match your criteria Chagas Disease American Trypanosomiasis


Extracorporeal membrane oxygenation as a bridge for heart transplantation by Chagas cardiomyopathy

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):429-433. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Cardiología, Servicio de Anestesiología. Ciudad de México, México

Background: Extracorporeal membrane oxygenation is a technique indicated in cases of severe respiratory failure or in situations where pump failure or heart failure is refractory to conventional medical treatment. Our goal was to describe the results of a patient with chronic Chagas dilated cardiomyopathy treated with extracorporeal membrane oxygenation as bridging therapy for heart transplantation.

Case Report: A 62-year old male with a history of Chagas disease and severe ventricular failure who underwent veno-arterial extracorporeal membrane oxygenation as bridging therapy for heart transplantation, with good clinical evolution. Read More

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November 2018
2 Reads

Docosahexaenoic acid promotes cell cycle arrest and decreases proliferation through WNT/β-catenin modulation in colorectal cancer cells exposed to γ-radiation.

Biofactors 2018 Dec 6. Epub 2018 Dec 6.

Cellular and Molecular Oncobiology Program, Brazilian National Cancer Institute, Rio de Janeiro, RJ, Brazil.

The effects of radiation are known to be potentiated by N-3 polyunsaturated fatty acids, which modulate several signaling pathways, but the molecular mechanisms through which these fatty acids enhance the anticancer effects of irradiation in colorectal cancer (CRC) treatment remain poorly elucidated. Here, we aimed to ascertain whether the fatty acid docosahexaenoic acid (DHA) exerts a modulating effect on the response elicited by radiation treatment (RT). Two CRC cell lines, Caco-2 and HT-29, were exposed to RT, DHA, or both (DHA + RT) for various times, and then cell viability, proliferation, and clonogenicity were assessed. Read More

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December 2018

Seroprevalence and geographical distribution of sero-positive blood donors to Trypanosoma cruzi at the central blood bank of the National Medical Center "La Raza".

Transfusion 2018 Dec 5. Epub 2018 Dec 5.

Departamento de Farmacobiología, Universidad de "La Cañada", Teotitlán de Flores Magón, Oaxaca, Mexico.

Background: Trypanosoma cruzi is a protozoan parasite that causes Chagas disease endemic to Latin-America. It is estimated that 1.0 to 1. Read More

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December 2018

Archaea Symbiont of Infection May Explain Heart Failure in Chagas Disease.

Front Cell Infect Microbiol 2018 21;8:412. Epub 2018 Nov 21.

Instituto do Coraçao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

Archaeal genes present in may represent symbionts that would explain development of heart failure in 30% of Chagas disease patients. Extracellular vesicles in peripheral blood, called exosomes (< 0.1 μm) or microvesicles (>0. Read More

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November 2018

The inflammasome in leprosy skin lesions: an immunohistochemical evaluation.

Infect Drug Resist 2018 12;11:2231-2240. Epub 2018 Nov 12.

Center of Biological and Health Science, State University of Para, Belem, Brazil,

Objective: Leprosy is a chronic infectious disease presenting with a spectrum of clinical manifestations that correspond to the type of immune response that develops in the host. Factors that may be involved in this process include inflammasomes, cytosolic proteins responsible for the activation of caspase 1, IL-1β and IL-18 secretion, and induction of a type of death called pyroptosis.

Patients And Methods: We evaluated the expression of inflammasome markers (nucleotide-binding oligomerization domain-like receptor containing pyrin domain 1 [NLRP1], nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 [NLRP3], caspase 1, IL-1β, and IL-18) by immunohistochemistry in 43 samples of skin lesions of leprosy patients from the groups indeterminate (I) leprosy (13 patients), tuberculoid (TT) leprosy (15 patients), and lepromatous leprosy (LL; 15 patients). Read More

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November 2018

Biogas from microalgae: an overview emphasizing pretreatment methods and their energy return on investment (EROI).

Biotechnol Lett 2018 Dec 1. Epub 2018 Dec 1.

School of Chemistry, Federal University of Rio de Janeiro, Av. Athos da Silveira Ramos, no 149, Bloco E, Sala 200, Cidade Universitária, Rio de Janeiro, 21941-909, Brazil.

Studies have reported enhancements in methane yield from pretreatment methods that benefit the anaerobic digestion (AD) of microalgae. However, energy return on investment (EROI), i.e. Read More

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December 2018

Triatomines: Trypanosomatids, Bacteria, and Viruses Potential Vectors?

Front Cell Infect Microbiol 2018 16;8:405. Epub 2018 Nov 16.

Laboratório de Interação Patógeno-Hospedeiro, Instituto de Ciências Biológicas, Departamento de Biologia Celular, Universidade de Brasília, Brasília, Brazil.

Triatominae bugs are the vectors of Chagas disease, a major concern to public health especially in Latin America, where vector-borne Chagas disease has undergone resurgence due mainly to diminished triatomine control in many endemic municipalities. Although the majority of Triatominae species occurs in the Americas, species belonging to the genus occur in India, and species belonging to the complex have been also identified in Africa, the Middle East, South-East Asia, and in the Western Pacific. Not all of Triatominae species have been found to be infected with , but the possibility of establishing vector transmission to areas where Chagas disease was previously non-endemic has increased with global population mobility. Read More

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November 2018
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Oropouche orthobunyavirus: Genetic characterization of full-length genomes and development of molecular methods to discriminate natural reassortments.

Infect Genet Evol 2018 Nov 29. Epub 2018 Nov 29.

The Center for Genome Science, US Army Medical Research Institute of Infectious Disease at Fort Detrick, MD, USA.

Oropouche orthobunyavirus (OROV) has significant impact in public health in Amazon region. This arbovirus is one of the most common causes of febrile illness in Brazil, and is responsible for several epidemics since 1960's. In this study, we sequenced and characterized the complete coding sequences (S-, M- and L-RNA) of 35 OROV isolates from Brazil. Read More

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November 2018

Trypanosoma cruzi immunoproteome: Calpain-like CAP5.5 differentially detected throughout distinct stages of human Chagas disease cardiomyopathy.

J Proteomics 2018 Nov 29. Epub 2018 Nov 29.

Laboratório de Biologia Celular, IOC, Fiocruz, Rio de Janeiro, RJ, Brazil. Electronic address:

Chagas disease, caused by the protozoan Trypanosoma cruzi, affects millions of people worldwide, especially in Latin America. Approximately 30% of the cases evolve to the chronic symptomatic stage due to cardiac and/or digestive damage, generally accompanied by nervous system impairment. Given the higher frequency and severity of clinical manifestations related to cardiac tissue lesion, the goal of this study was the identification of proteins associated with the disease progression towards its cardiac form. Read More

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November 2018

Type 1 cardiorenal syndrome in a patient with an acute infection caused by Trypanosoma cruzi in the Brazilian Amazon region - a case report.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):869-872

Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, AM, Brasil.

Cardiorenal syndrome type 1 (CRS 1) occurs when acute heart failure leads to acute kidney injury. There are several etiologies of CRS 1, including Chagas disease. Here, we present the first case report of CRS 1 in a patient with acute Chagas disease. Read More

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April 2018
1 Read

Antiprotozoal action of synthetic cinnamic acid analogs.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):849-853

Plataforma de Bioensaios em Malária e Leishmaniose, Fundação Oswaldo Cruz, Porto Velho, RO, Brasil.

Introduction: Leishmaniasis, Chagas disease, and malaria cause morbidity globally. The drugs currently used for treatment have limitations. Activity of cinnamic acid analogs against Leishmania spp. Read More

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December 2017
2 Reads

Using a Chagas disease hospital database: a clinical and epidemiological patient profile.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):831-835

Departamento de Bioquímica e Biologia Tecidual, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brasil.

Introduction: Chagas disease (CD) prevention and control rely on studies of its distribution, characteristics of individuals affected and mode of transmission. CD data in Brazil are scarce; a retrospective analysis of the clinical characteristics of 80 patients treated at the Clinical Hospital of UNICAMP, Campinas, Brazil, was performed.

Methods: Patient data records were analyzed. Read More

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December 2017
2 Reads

Echocardiographic Study of the Coronary Sinus in the Indeterminate Form of Chagas Disease.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):827-830

Núcleo de Medicina Tropical, Universidade de Brasília. Brasília, DF, Brasil.

Introduction: We investigated the occurrence of coronary sinus abnormalities in the indeterminate form of Chagas disease (CD).

Methods: Differences between the maximum and minimum diameters of the coronary sinus (∆%) on echocardiography were evaluated in individuals with the indeterminate form of CD (n=14) and those without (n=16) CD. The association of the difference with abnormalities detected by echocardiography and myocardial scintigraphy was assessed. Read More

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November 2017
2 Reads

Hepatitis E virus infection among rural Afro-descendant communities from the eastern Brazilian Amazon.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):803-807

Seção de Hepatologia, Instituto Evandro Chagas, Belém, PA, Brasil.

Introduction: The prevalence, public health impact, and epidemiological characteristics of hepatitis E virus (HEV) are poorly understood in Brazil.

Methods: Serum samples from 535 individuals from three rural Afro-descendant communities located in eastern Brazilian Amazon were collected in October 2015 and tested for presence of anti-HEV IgM and IgG antibodies. Serologically positive samples were also tested for HEV-RNA. Read More

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October 2017

Favorable responses to treatment with 5 mg Sbv/kg/day meglumine antimoniate in patients with American tegumentary leishmaniasis acquired in different Brazilian regions.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):769-780

Fundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses, Rio de Janeiro, RJ, Brasil.

Introduction: Favorable responses in American tegumentary leishmaniasis (ATL) patients to treatment with 5 mg Sbv/kg/day meglumine antimoniate (MA) has been reported in Rio de Janeiro, but little is known regarding the therapeutic response to low doses in patients from other locations.

Methods: A retrospective review of medical records was conducted to compare the therapeutic response to 5 mg Sbv/kg/day MA treatment among 36 patients who acquired ATL in Brazilian states other than Rio de Janeiro (OS group) and 72 patients from Rio de Janeiro (RJ group).

Results: One course of 5 mg Sbv/kg/day MA cured 72. Read More

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December 2017
1 Read

Healing effect of andiroba-based emulsion in cutaneous wound healing via modulation of inflammation and transforming growth factor beta 31.

Acta Cir Bras 2018 Nov;33(11):1000-1015

MD, Postgraduate Program in Surgical Science, Department of Surgery, School of Medicine, UFRJ, Rio de Janeiro-RJ, Brazil. Manuscript writing, critical revision, final approval.

Purpose: To evaluate the effects and mechanisms of andiroba-based emulsion (ABE) topical treatment on full-thickness cutaneous wounds in rats.

Methods: The wounds were harvested on days 3, 7, 15, and 20 post-surgery. Wound contraction rate, quantitative immunohistochemistry [macrophages, myofibroblasts, capillaries, collagens (col) I and III, transforming growth factor β3β (TGFβ3)], and tensile strength were assessed. Read More

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November 2018
3 Reads

Adverse drug events identified in hospitalized patients in Brazil by International Classification of Diseases (ICD-10) code listings.

Cad Saude Publica 2018 Nov 29;34(12):e00222417. Epub 2018 Nov 29.

Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.

Studies of adverse drug events (ADEs) are important in order not to jeopardize the positive impact of pharmacotherapy. These events have substantial impact on the population morbidity profiles, and increasing health system operating costs. Administrative databases are an important source of information for public health purposes and for identifying ADEs. Read More

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November 2018
1 Read

The artery of Mouchet: blood supply of the septomarginal trabecula in 50 human hearts.

Rev Assoc Med Bras (1992) 2018 Oct;64(10):916-921

Morphology Department, Fluminense Federal University, Niterói/RJ, Brasil.

The septomarginal trabecula is a muscular structure which transmits the right branch of the atrioventricular bundle. It is usually supplied by a branch from the second anterior septal artery. Anastomoses between the right and left coronary arteries may happen on the septomarginal trabecula. Read More

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October 2018

Trypanosoma cruzi-specific IFN-γ-producing cells in chronic Chagas disease associate with a functional IL-7/IL-7R axis.

PLoS Negl Trop Dis 2018 Dec 5;12(12):e0006998. Epub 2018 Dec 5.

Instituto Nacional de Parasitología Dr. Fatala Chaben, Buenos Aires, Argentina.

Background: The severity of cardiac disease in chronic Chagas disease patients is associated with different features of T-cell exhaustion. Here, we assessed whether the ability of T cells to secrete IFN-γ in response to T. cruzi was linked to disruption in immune homeostasis and inflammation in patients with chronic Chagas disease. Read More

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December 2018

Sex differences in subcutaneous adipose tissue redox homeostasis and inflammation markers in control and high fat diet fed rats.

Appl Physiol Nutr Metab 2018 Dec 5. Epub 2018 Dec 5.

Universidade Federal do Rio de Janeiro, 28125 , Avenida Carlos Chagas Filho, 373 , Rio de Janeiro, Brazil , 21941-901 ;

The development of obesity related-metabolic disorders is more evident in male in comparison to female subjects, but the mechanisms are unknown. Several studies have shown that oxidative stress is involved in the pathophysiology of obesity, but the majority of them were performed in male animals. The aim of this study was to evaluate the sex-related differences in the subcutaneous adipose tissue redox homeostasis and inflammation of rats chronically fed a high fat diet. Read More

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December 2018

Ischemic stroke and infectious diseases in low-income and middle-income countries.

Curr Opin Neurol 2018 Dec 3. Epub 2018 Dec 3.

Serviço de Neurologia, Hospital das Clínicas da Universidade Federal de Minas Gerais/EBSERH.

Purpose Of Review: To address the important relationships between stroke and infection, focusing on the most frequent infections found in low-income and middle-income countries.

Recent Findings: Stroke is one of the leading causes of mortality and disability worldwide, with a great proportion of the stroke burden occurring in low-income and middle-income countries. Infectious diseases are still a great health problem in developing countries and it is possible that the proportion of infection-related strokes is greater in these nations. Read More

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December 2018

High-fat diet withdrawal modifies alcohol preference and transcription of dopaminergic and GABAergic receptors.

J Neurogenet 2018 Dec 5:1-11. Epub 2018 Dec 5.

a Laboratório de Genética Animal e Humana, Departamento de Biologia Geral, Instituto de Ciências Biológicas , Universidade Federal de Minas Gerais , Belo Horizonte , Brazil.

The bidirectional and positive relation between the ingestion of fat and alcohol has become the subject of extensive discussion. However, this relation is more studied in animal models of binge eating with intermittent access of high-fat diet or in a model of short period of this diet consumption. Here, we developed a model to elucidate how chronic high-fat diet and its withdrawal influence alcohol intake (two-bottle choice) and anxiety behavior (marble burying test). Read More

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December 2018

Insights Into sp. Metabolism Based on Comparative Genomics.

Front Microbiol 2018 20;9:2811. Epub 2018 Nov 20.

Laboratório de Tecnologia Biomolecular, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Brazil.

Currently only four genome sequences for spp. are publicly available, and information on the genetic properties of cyanobacteria belonging to this genus is limited. In this study, we report the draft genome of sp. Read More

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November 2018

Building capacity for advances in tuberculosis research; proceedings of the third RePORT international meeting.

Tuberculosis (Edinb) 2018 Dec 1;113:153-162. Epub 2018 Oct 1.

FHI 360 and Duke University, Durham, NC, USA. Electronic address:

RePORT International is a global network of research sites in India, Brazil, Indonesia, South Africa, China, and the Philippines dedicated to collaborative tuberculosis research in the context of HIV. A standardized research protocol (the Common Protocol) guides the enrollment of participants with active pulmonary tuberculosis and contacts into observational cohorts. The establishment of harmonized clinical data and bio-repositories will allow cutting-edge, large-scale advances in the understanding of tuberculosis, including identification of novel biomarkers for progression to active tuberculosis and relapse after treatment. Read More

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December 2018

Analysis of potential household transmission events of tuberculosis in the city of Belem, Brazil.

Tuberculosis (Edinb) 2018 Dec 2;113:125-129. Epub 2018 Oct 2.

Universidade do Estado do Pará, Programa de Pós-graduação em Biologia Parasitária na Amazônia, Belém, Brazil; Instituto Evandro Chagas, Seção de Bacteriologia e Micologia, Belém, Brazil. Electronic address:

Tuberculosis (TB) is an infectious disease with a higher risk for infection and disease among household contacts (HHC). Here, we report a molecular epidemiology-based approach to study disease transmission and the genetic characteristics of Mycobacterium tuberculosis (Mtb) strains among HHC in the city of Belem, the capital of the state of Para in north Brazil. The study included 63 TB patients belonging to 26 HHC groups (HHC1 to HHC26). Read More

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December 2018

Characterization and functionality of two members of the SPFH protein superfamily, prohibitin 1 and 2 in Leishmania major.

Parasit Vectors 2018 Dec 4;11(1):622. Epub 2018 Dec 4.

Department of Parasitology, Faculty of Science, University of Granada, Granada, Spain.

Background: Leishmaniasis, a disease caused by parasites of the genus Leishmania, infects roughly 12 million people worldwide, with about two million new cases per year. Prohibitins (PHBs) are highly conserved proteins belonging to the stomatin-prohibitin flotillin-HflC/K (SPFH) protein superfamily. In this study, we examine the potential functions of two proteins of Leishmania major, PHB1 and PHB2, as well as how they might help protect the protozoan against oxidative stress. Read More

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December 2018

Association between Cluster of Lifestyle Behaviors and HOMA-IR among Adolescents: ABCD Growth Study.

Medicina (Kaunas) 2018 Dec 1;54(6). Epub 2018 Dec 1.

Laboratory of InVestigation in Exercise-LIVE, Department of Physical Education, Sao Paulo State University (UNESP), Presidente Prudente, Sao Paulo 19060-900, Brazil.

To analyze the association of potential risk factors to health with body fatness and insulin resistance. Baseline measures of the ongoing longitudinal Analysis of Behaviors of Children During (ABCD) Growth Study. The sample was composed of 280 adolescents of both sexes (198 boys and 82 girls) aged from 10 to 18 years. Read More

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December 2018

Leishmanicidal Activity of Withanolides from var. .

Molecules 2018 Nov 30;23(12). Epub 2018 Nov 30.

Laboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), 210360-040 Rio de Janeiro, Brazil.

Leishmaniasis is the generic denomination to the neglected diseases caused by more than 20 species of protozoa belonging to the genus . The toxic and parenteral-delivered pentavalent antimonials remain to be the first-line treatment. However, all the current used drugs have restrictions. Read More

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November 2018

Polysome profiling followed by RNA-seq of cardiac differentiation stages in hESCs.

Sci Data 2018 Dec 4;5:180287. Epub 2018 Dec 4.

Stem Cells Basic Biology Laboratory, Instituto Carlos Chagas - FIOCRUZ-PR, Rua Professor Algacyr Munhoz Mader, 3775, 81.350-010 Curitiba, Brazil.

The regulation of gene expression acts at numerous complementary levels to control and refine protein abundance. The analysis of mRNAs associated with polysomes, called polysome profiling, has been used to investigate the post-transcriptional mechanisms that are involved in different biological processes. Pluripotent stem cells are able to differentiate into a variety of cell lineages, and the cell commitment progression is carefully orchestrated. Read More

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December 2018
7 Reads

In vitro antiprotozoal activity of some medicinal plants against sleeping sickness, Chagas disease and leishmaniasis.

Future Med Chem 2018 Dec 4. Epub 2018 Dec 4.

Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Ainy Street, Cairo, 11562, Egypt.

Aim: Antiprotozoal activity of 36 medicinal plants was evaluated.

Materials & Methods: In vitro potency against Trypanosoma brucei brucei, T. b. Read More

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December 2018
4 Reads

Neuroprotective Actions of Glucagon-Like Peptide-1 (GLP-1) Analogues in Alzheimer's and Parkinson's Diseases.

CNS Drugs 2018 Dec 3. Epub 2018 Dec 3.

Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21944-590, Brazil.

The current absence of effective treatments for Alzheimer's disease (AD) and Parkinson's disease (PD) reflects an incomplete knowledge of the underlying disease processes. Considerable efforts have been made to investigate the central pathological features of these diseases, giving rise to numerous attempts to develop compounds that interfere with such features. However, further characterization of the molecular targets within the interconnected AD and PD pathways is still required. Read More

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December 2018

Real-Time PCR for the Evaluation of Treatment Response in Clinical Trials of Adult Chronic Chagas Disease: Usefulness of Serial Blood Sampling and qPCR Replicates.

Antimicrob Agents Chemother 2018 Dec 3. Epub 2018 Dec 3.

Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland

This work evaluated a serial blood sampling procedure to enhance the sensitivity of duplex real-time PCR (qPCR) for baseline detection and quantification of parasitic loads and post-treatment identification of failure in the context of clinical trials for treatment of chronic Chagas disease, namely DNDi-CH-E1224-001 (NCT01489228) and MSF-DNDi PCR sampling optimization study (NCT01678599). Patients from Cochabamba (N= 294), Tarija (N= 257), and Aiquile (N= 220) were enrolled. Three serial blood samples were collected at each time-point and qPCR triplicates were tested per sample. Read More

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December 2018

Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis.

PLoS One 2018 30;13(11):e0207644. Epub 2018 Nov 30.

Clinical Laboratory and Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

Feline sporotrichosis due to Sporothrix brasiliensis is frequently severe and often correlated to zoonotic transmission. Feline Immunodeficiency Virus (FIV) and Feline Leukemia Virus (FeLV) cause immunodeficiency in cats; no association has been identified with critical cases of sporotrichosis. Moreover, the cytokine profile in Sporothrix-infected cats and a potential impact of retrovirus co-infections on their immunity is unknown. Read More

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November 2018
1 Read

High rate of seromarkers for HIV, HBV and syphilis among blood donors using confidential unit exclusion, before and after HIV-NAT implementation at a major public blood bank in the Brazilian Amazon.

Transfusion 2018 Nov 30. Epub 2018 Nov 30.

Tropical Pathology and Public Health Institute, Federal University of Goias, Goiania, Brazil.

Background: Confidential unit exclusion (CUE) was introduced in the 1980's as an additional layer to blood safety, before highly specific and sensitive nucleic acid tests (NAT) for HIV were implemented. The utility of CUE-use in settings that have implemented NAT should be evaluated over time.

Study Design, Methods: Cross-sectional retrospective study carried out from June 2010-November 2015, at Manaus Hemocenter (HEMOAM), Amazonas, Brazil that implemented HIV-NAT in 2012. Read More

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November 2018

Repeated cross-sectional study of Trypanosoma cruzi in shelter dogs in Texas, in the context of Dirofilaria immitis and tick-borne pathogen prevalence.

J Vet Intern Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Veterinary Integrative Biosciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas.

Background: Vector-borne diseases have an adverse impact on health of dogs, and infected dogs can be sentinels for human infection. Infection with Trypanosoma cruzi, an agent of Chagas disease, causes fatal heart disease in dogs across the southern United States but has been neglected from wide-scale prevalence studies.

Objectives: To determine the prevalence of exposure to T. Read More

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November 2018
2 Reads

TcVac1 vaccine delivery by intradermal electroporation enhances vaccine induced immune protection against Trypanosoma cruzi infection in mice.

Vaccine 2018 Nov 26. Epub 2018 Nov 26.

Centro de Investigación y Estudios Avanzados en Salud Animal, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Km 15.5 Carretera Panamericana Toluca-Atlacomulco, Toluca, Estado de México C.P. 50200, Mexico. Electronic address:

The efforts for the development and testing of vaccines against Trypanosoma cruzi infection have increased during the past years. We have designed a TcVac series of vaccines composed of T. cruzi derived, GPI-anchored membrane antigens. Read More

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November 2018
2 Reads

Association between typical electrocardiographic abnormalities and NT-proBNP elevation in a large cohort of patients with Chagas disease from endemic area.

J Electrocardiol 2018 Nov - Dec;51(6):1039-1043. Epub 2018 Aug 23.

Programa de Pós-graduação Infectologia e Medicina Tropical, Faculdade de Medicina da Universidade Federal de Minas Gerais, Minas Gerais, Brazil; Centro de Telessaúde do Hospital das Clínicas da Universidade Federal de Minas Gerais, Brazil. Electronic address:

Chagas cardiomyopathy is the most harmful complication of Chagas disease. The electrocardiogram is a well-studied exam and has been considered an important tool for detection and evaluation of Chagas cardiomyopathy since the first years of its description. Many of its abnormalities have been described as associated with a worse prognosis. Read More

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Influence of Baseline Physical Activity Level on Exercise Training Response and Clinical Outcomes in Heart Failure: The HF-ACTION Trial.

JACC Heart Fail 2018 Dec;6(12):1011-1019

National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland. Electronic address:

Objectives: This study sought to evaluate the influence of baseline physical activity (PA) on responses to aerobic exercise training and clinical events in outpatients with chronic systolic heart failure (HF) from the multicenter HF-ACTION (Exercise Training Program to Improve Clinical Outcomes in Individuals With Congestive Heart Failure) trial.

Background: The influence of baseline PA on exercise capacity, responses to exercise training and clinical outcomes in patients with chronic HF is unclear.

Methods: Of 2,130 participants who provided consent for this analysis, 1,494 patients (64%) had complete baseline PA data, using a modified version of the International Physical Activity Questionnaire-Short Form questionnaire and were included in the analysis; 742 received usual care and 752 were allocated to the exercise training group. Read More

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December 2018

Ecological aspects of Phlebotomines (Diptera: Psychodidae) and the transmission of American cutaneous leishmaniasis agents in an Amazonian/ Guianan bordering area.

Parasit Vectors 2018 Nov 29;11(1):612. Epub 2018 Nov 29.

Seção de Parasitologia, Instituto Evandro Chagas (Secretaria de Vigilância em Saúde, Ministério da Saúde), Ananindeua, Pará State, Brazil.

Background: An entomological study was conducted in the municipality of Oiapoque (lower Oyapock River Basin) in the Brazilian side bordering French Guiana to gain information on the transmission pattern of American cutaneous leishmaniasis (ACL) in that region, presumed to reflect the classical Amazonian/Guianan enzootic scenario.

Methods: Three ecologically isolated forested areas near urban environments were surveyed during the rainy and dry seasons of 2015 and 2016, using a multi-trapping approach comprising ground-level and canopy light traps, black and white colored cloth Shannon traps and manual aspiration on tree bases. Female phlebotomines were dissected to find infections and isolate flagellates from Leishmania spp. Read More

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November 2018
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Differential expression of proteins in genetically distinct Trypanosoma cruzi samples (TcI and TcII DTUs) isolated from chronic Chagas disease cardiac patients.

Parasit Vectors 2018 Nov 29;11(1):611. Epub 2018 Nov 29.

Programa de Pós-Graduação em Ciências Biológicas do Núcleo de Pesquisas em Ciências Biológicas (NUPEB), Campus Universitário Morro do Cruzeiro, Universidade Federal de Ouro Preto, CEP, Ouro Preto, MG, 35400-000, Brazil.

Background: Trypanosoma cruzi, a hemoflagellate protozoan parasite and the etiological agent of Chagas disease (CD), exhibits great genetic and biological diversity. Infected individuals may present clinical manifestations with different levels of severity. Several hypotheses have been proposed to attempt to correlate the diversity of clinical signs and symptoms to the genetic variability of T. Read More

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November 2018

CDCA5 overexpression is an Indicator of poor prognosis in patients with hepatocellular carcinoma (HCC).

BMC Cancer 2018 Nov 29;18(1):1187. Epub 2018 Nov 29.

Department of Radiology, Wayne State University, Detroit, MI, 48201, USA.

Background: Accurate and early prognosis of disease is essential to clinical decision making, particularly in diseases, such as HCC, that are typically diagnosed at a late stage in the course of disease and therefore carry a poor prognosis. CDCA5 is a cell cycle regulatory protein that has shown prognostic value in several cancers.

Methods: We retrospectively evaluated 178 patients with HCC treated with curative liver resection between September 2009 and September 2012 at Nanchong Central Hospital in Nanchong, Sichuan Province, China. Read More

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November 2018

Evaluating the effects of anticoagulants on Rhodnius prolixus artificial blood feeding.

PLoS One 2018 29;13(11):e0206979. Epub 2018 Nov 29.

Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.

Blood-sucking insects are responsible for the transmission of several important disease-causing organisms such as viruses, bacteria, and protozoans. The hematophagous hemipteran Rhodnius prolixus is one of the most important vectors of Trypanosoma cruzi, the etiological agent of Chagas disease. Due to the medical importance of this insect, it has been used as a study model in physiology and biochemistry since the 1930s. Read More

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November 2018

Monitoring the parasite load in chronic Chagas disease patients: comparison between blood culture and quantitative real time PCR.

PLoS One 2018 29;13(11):e0208133. Epub 2018 Nov 29.

Programa de Pós-Graduação em Parasitologia, Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Background: Despite the improvements in diagnostic tools for detection of Trypanosoma cruzi in human blood samples, the isolation of parasite from bloodstream in the chronic phase of Chagas disease is challenging. Thus, there is an increasing interest in the development of strategies that allow an accurate monitoring of the parasite load in bloodstream of Chagas disease patients. Given that, the comparison of a classical diagnostic method such as blood culture and multiplex quantitative real-time PCR (qPCR) was few explored so far. Read More

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November 2018

High prevalence of sexual Chlamydia trachomatis infection in young women from Marajó Island, in the Brazilian Amazon.

PLoS One 2018 29;13(11):e0207853. Epub 2018 Nov 29.

Laboratório de Biologia Molecular e Celular, Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém, Pará, Brasil.

Background: Chlamydia trachomatis is the most prevalent bacterial sexually transmitted infection (STI) in the world. Approximately 80% of infected women are asymptomatic, although this infection can lead to serious complications in the female reproductive tract. Few data on Chlamydia infection are available in rural Amazonian communities. Read More

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November 2018

Integrating evidence, models and maps to enhance Chagas disease vector surveillance.

PLoS Negl Trop Dis 2018 Nov 29;12(11):e0006883. Epub 2018 Nov 29.

Department of Biostatistics, Epidemiology & Informatics; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.

Background: Until recently, the Chagas disease vector, Triatoma infestans, was widespread in Arequipa, Perú, but as a result of a decades-long campaign in which over 70,000 houses were treated with insecticides, infestation prevalence is now greatly reduced. To monitor for T. infestans resurgence, the city is currently in a surveillance phase in which a sample of houses is selected for inspection each year. Read More

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November 2018
3 Reads

Chagas disease: An underrecognized diagnosis.

JAAPA 2018 Dec;31(12):30-33

Dan M. Tzizik practices in the ED at Portsmouth (N.H.) Regional Hospital. Roy A. Borchardt is supervisor of advanced practice providers at M.D. Anderson Cancer Center's Department of Infectious Diseases, Infection Control and Employee Health, in Houston, Tex. The authors have disclosed no potential conflicts of interest, financial or otherwise.

Chagas disease is a parasite infection primarily transmitted to humans via the bite of triatomine insect vectors. Up to 8 million people are estimated to be infected with Chagas disease in the Americas. Patients who do not receive treatment can develop severe cardiac debility, gastrointestinal organ dysfunction, and may die. Read More

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December 2018
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Paper-Based Electrophoresis Microchip as a Powerful Tool for Bioanalytical Applications.

Methods Mol Biol 2019 ;1906:133-142

Institute of Chemistry, Federal University of Goias, Goiania, GO, Brazil.

This chapter describes the development of paper-based microchip electrophoresis (pME) devices for the separation of clinically relevant compounds. pME were fabricated by laser cut and thermal lamination process using polyester pouches. In addition, hand-drawn pencil electrodes were integrated to the device to perform capacitively coupled contactless conductivity detection (CD). Read More

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January 2019

Zika Virus Epidemic in Brazil. II. Post-Mortem Analyses of Neonates with Microcephaly, Stillbirths, and Miscarriage.

J Clin Med 2018 Nov 28;7(12). Epub 2018 Nov 28.

Seção de Arbovirologia e Febres Hemorrágicas, Instituto Evandro Chagas, Ministério da Saúde, RodoviaBR-316, km-07, Ananindeua67030-000, Pará, Brazil.

Introduction: The recent Zika virus(ZIKV) epidemic in Brazil was characterized by a range of different clinical presentations, particularly microcephaly, Guillain-Barré syndrome, and death. In this context, we determined the causal relationship between fatal microcephaly cases and ZIKV infection.

Methods: Twelve fatal cases of neonates, whose mothers were infected with ZIKV during pregnancy, were examined; cases included nine neonatal deaths due to microcephaly, one miscarriage, and two stillbirths. Read More

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November 2018

A new genus of calcareous sponge discovered in the Caribbean Sea: Bidderia gen. nov. (Porifera, Calcarea, Calcinea).

Zootaxa 2018 Nov 28;4526(1):56-70. Epub 2018 Nov 28.

Universidade Federal do Rio de Janeiro, Instituto de Biologia, Departamento de Zoologia, Av. Carlos Chagas Filho, 373, CCS, Bloco A, sala A0-100, Rio de Janeiro, RJ, Brasil, 21941-902.

Calcareous sponges from the Lesser Antilles were recently inventoried and several specimens morphologically resembling species of the genus Ascoleucetta were collected. Morphological and molecular (C-LSU and ITS) analyses indicated that these specimens from the Lesser Antilles constituted a new genus. They lack the conspicuous and very characteristic ornamentation of the inhalant apertures found in two out of three species of Ascoleucetta, including the type species A. Read More

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November 2018

Implementation science: Epidemiology and feeding profiles of the Chagas vector Triatoma dimidiata prior to Ecohealth intervention for three locations in Central America.

PLoS Negl Trop Dis 2018 Nov 28;12(11):e0006952. Epub 2018 Nov 28.

The Applied Entomology and Parasitology Laboratory at Biology School, Pharmacy Faculty, San Carlos University of Guatemala, Guatemala City, Guatemala.

The Ecohealth strategy is a multidisciplinary data-driven approach used to improve the quality of people's lives in Chagas disease endemic areas, such as regions of Central America. Chagas is a vector-borne disease caused by the parasite Trypanosoma cruzi. In Central America, the main vector is Triatoma dimidiata. Read More

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November 2018