1,655 results match your criteria Ceskoslovenska patologie[Journal]


A case of amoebic colitis with Crohn-like endoscopic and histopathological features.

Cesk Patol 2020 ;56(2):95-98

Amoebic colitis represents a common parasitic infection in developing countries. In western world, it is encountered only sporadically. The clinical presentation is usually non-specific, non-invasive laboratory tests are often false negative and endoscopic and histopathological appearance may mimic other illnesses, especially Crohns disease. Read More

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January 2020

Dermatofibrosarcoma protuberans with fibrosarcomatous transformation: a case report.

Cesk Patol 2020 ;56(2):89-93

Dermatofibrosarcoma protuberans is a quite rare local aggressive tumor of dermis and subcutis, revealing characteristic morphology and chromosomal translocation (17; 22)(q21;q13) with gene fusion COL1A1-PDGFB. The tumour almost never metastasizes and complete excision signs an excellent prognosis. Approximately in 10% of cases, dermatofibrosarcoma undergoes a fibrosarcomatous transformation associated with metastatic disease and worse prognosis. Read More

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January 2020

Secondary vasculitis - omitted manifestation of many diseases.

Authors:
Radim Bečvář

Cesk Patol 2020 ;56(2):83-88

Secondary vasculitides usually accompany various common and rare conditions, Their clinical picture is very diverse, they can be loclaized or genaralized. Most frequently, we find parainfectious, drug-related and paraneoplastic vasculitides, less commonly in connective tissue diseases, after radiotherapy or transplantation. Vasculitides may be associated to infection of any origin. Read More

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January 2020

Primary vasculitides - current diagnostics and therapy.

Authors:
Radim Bečvář

Cesk Patol 2020 ;56(2):74-82

By term „vasculitis“ inflammatory disease of blood vessels is designated that leads to vessel wall destruction followed by proliferation and occlusion of their lumina. Basic condition for this diagnosis is that vessel wall is a primary site of the pathological process. Clinical syndromes are a consequence of this process resulting into ischaemia of tissues supplied by the affected vessels and with constitutional symptoms associated to the inflammatory disease. Read More

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January 2020

How to improve the histopathological diagnosis of systemic vasculitides in daily practice?

Authors:
Eva Honsová

Cesk Patol 2020 ;56(2):68-73

The most common group of systemic vasculitides in adulthood are anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). AAV represent autoimmune systemic vasculitides and include 3 clinical phenotypes: Granulomatosis with polyangiitis (GPA, formerly Wegener granulomatosis), Microscopic polyangiitis (MPA) and Eosinophilic granulomatosis with polyangiitis (EGPA, formerly Churg-Strauss syndrome). Histological features are similar to each other in all affected locations, and there are represented by necrotizing vascular inflammation of small and medium calibers, often venules, capillaries or arteriols, typically with fibrinoid vessel wall necrosis. Read More

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January 2020

Pathophysiology of ANCA-associated vasculitis.

Cesk Patol 2020 ;56(2):65-67

ANCA positive vasculitis (AAV) is a serious autoimmune disease mainly affecting small vessels in various organ systems, accompanied by the presence of ANCA antibodies in serum. AAV represents a group of the most common systemic vasculitis in adulthood, and based on clinical manifestations this disease entity includes 3 phenotypes, namely: granulomatosis with polyangiitis (formerly Wegeners granulomatosis), microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss syndrome). Similar to other autoimmune diseases, AAV develops in patients with a predisposing genetic background who have been exposed to causative environmental factors, such as infections. Read More

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January 2020

The role of a pathologist in surgical staging for carcinoma of the cervix uteri.

Cesk Patol 2020 ;56(1):38-44

The incidence of cervical cancer is high in the Czech Republic. Altogether 822 new cases were found in this country during 2016 which means the incidence 15,3 new diseases / 100,000 women. FIGO (Fédération Internationale de Gynécologie et d´Obstétrique) staging of carcinoma for the cervix was changed as follows. Read More

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January 2020

Echinococcus multilocularis: Diagnostic problem in a liver core biopsy.

Cesk Patol 2020 ;56(1):32-34

Echinococcus multilocularis causes an aggressive form of hydatidosis whose histomorphological picture is generally not well recognized. We report a case of 39-year-old women presenting with poorly circumscribed nodules in the right hepatic lobe. Owing to the clinical suspicion of focal nodular hyperplasia and hepatocellular adenoma, a core biopsy was performed. Read More

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January 2020

Current nomenclature and histopathological criteria for assessment of the noninflammatory degenerative diseases of the aorta.

Authors:
Ondřej Fabián

Cesk Patol 2020 ;56(1):26-31

A histopathological examination of the surgical specimen of the aorta usually follows a surgical reconstruction of the aortic aneurysm or dissection. Among the adults, the frequent cause of the aneurysm development is a severe atherosclerosis, while in children the aneurysm or dissection usually come as a complication of genetic syndromes. The common microscopical denominator of those diseases is a medial degeneration of variable degree. Read More

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January 2020

Differential diagnosis of heart tumours.

Cesk Patol 2020 ;56(1):18-25

Cardiac tumours represent a wide spectrum of neoplastic and non-neoplastic masses. Plenty of them, especially primary cardiac neoplasias, are rare diseases. Last revision of WHO classification introduced several changes in their histopathological assessment. Read More

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January 2020

State of the art in diagnostics of ischemic heart disease and current recommended therapeutic approach.

Cesk Patol 2020 ;56(1):13-17

Several changes have occurred during last few years in diagnostics and treatment of the ischemic heart disease, especially due to introduction of so called high-sensitive troponins, implementation of new antiplatelet drugs, using of drug-eluting stents in percutaneous coronary interventions or novel definitions of acute myocardial infarction types. The European Society of Cardiology and Czech Society of Cardiology established new recommendations for management of both acute and chronic forms of the ischemic heart disease. Recently discovered inhibitors of the PCSK9 molecule that have been slowly introduced in the clinical practice represent a breakthrough in the treatment of dyslipidemia. Read More

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January 2020

Chondroid melanoma. A case report.

Cesk Patol 2019 ;55(4):250-252

69-year-old woman diagnosed with malignant melanoma with chondroid differentiation, localized on the fifth finger of her right toe. This tumor represents a rare variant of melanoma, histomorphological features of which may lead to diagnostic uncertainty. Read More

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January 2020

Fumarate hydratase deficient renal cell carcinoma and fumarate hydratase deficient-like renal cell carcinoma: Morphologic comparative study of 23 genetically tested cases.

Cesk Patol 2019 ;55(4):244-249

Hereditary leiomyomatosis and renal cell carcinoma-associated renal cell carcinoma (HLRCC)/ fumarate hydratase deficient renal cell carcinoma (FHRCC) is an aggressive tumor defined by molecular genetic changes - alteration in fumarate hydratase (FH) gene. The morphologic spectrum of HLRCC/FHDRCC is remarkably variable. The presence of large nuclei and prominent dark red inclusion-like nucleoli and perinucleolar clearing are considered as helpful morphologic clue. Read More

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January 2020

Inflammatory myofibroblastic tumor of the uterus - case report.

Cesk Patol 2019 ;55(4):239-243

Inflammatory myofibroblastic tumor (IMT) of the uterus is rare but probably underdiagnosed tumor. It is usually benign but small fraction of cases may locally recur or rarely metastasize. Herein, we present a case report of 66-year-old patient with uterine IMT originally diagnosed as leiomyosarcoma of the uterus. Read More

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January 2020

Incidental idiopathic focal sclerosing mesenteritis in a 4-month-old child.

Cesk Patol 2019 ;55(4):235-238

Sclerosing mesenteritis is a rare non-cancerous disease affecting the small bowel mesentery, which occurs predominantly in older age. The exact etiology is not known. Clinical symptoms are very variable and they include abdominal pain and distention, nausea, and vomiting. Read More

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January 2020

Mantle cell lymphoma diagnosed from radical prostatectomy for prostate adenocarcinoma: a case report.

Cesk Patol 2019 ;55(4):231-234

We present a case of 64 - year - old man with mantle cell lymphoma (MCL) diagnosed in radical prostatectomy for adenocarcinoma. Lymphoma of the prostate, either primary or secondary, is a rare entity. The prognosis of lymphoma involving the prostate is usually poor. Read More

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January 2020

Recent advances in microscopic diagnosis of cardiomyopathies.

Cesk Patol 2019 ;55(4):224-230

A substantial proportion of cardiomyopathies (CMP) harbour non-specific microscopic findings and the diagnosis is based on the clinical phenotype. Therefore a majority of dilated and hypertrophic CMP are encountered by a pathologist as explanted hearts or during autopsy. The indication for the endomyocardial biopsy usually follows clinical suspicion for infiltrative disease and plays an important role in paediatric patients, where the metabolic CMP are more frequent. Read More

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January 2020

Histopathological diagnosis of myocarditis.

Cesk Patol 2019 ;55(4):218-223

Histopathological assessment of the endomyocardial biopsy represents a gold standard in diagnosis of myocarditis (MC). For a long time, the microscopic diagnosis relied on Dallas criteria. They defined MC on morphological grounds as a presence of inflammatory infiltrate accompanied by signs of myocyte damage. Read More

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January 2020

Clinical perspective on the myocarditis and cardiomyopathies.

Cesk Patol 2019 ;55(4):209-217

Myocardial diseases are often encountered in cardiology and pose a significant diagnostic challenge. Myocarditis is an acute inflammatory disease of the heart muscle. Pathophysiology of myocarditis is a complex interplay of genetic background, innate immunity, viral or bacterial agents and formation of autoreactive antibodies and lymphocytes that maintain the inflammation after the infection was eliminated. Read More

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January 2020

A practical approach to the examination of the congenitally malformed heart at autopsy.

Cesk Patol 2019 ;55(4):202-208

Congenital heart defects (CHD) represent the most frequent type of the heart disease in childhood, with incidence up to 1 % of all live-born children. Despite the improving echocardiographic diagnostics, part of CHD remains undiagnosed and can manifest in the later age or may be the cause of the early abortion. On the other hand, some foetuses with prenatally diagnosed severe CHD may be recommended to interruption. Read More

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January 2020

Atypical fibroxanthoma, rare and often unrecognized cutaneous soft tissue tumor - a case report and review of the literature.

Cesk Patol 2019 ;55(3):182-186

Atypical fibroxanthoma (AFX) is a rare cutaneous soft tissue tumor typically occurring in the elderly on sun exposed skin. Histologically, it is composed of pleomorphic, atypical cells with multiple mitoses including atypical mitotic figures resembling undifferentiated malignant tumor. AFX is considered to be a benign tumor with almost uniformly excellent prognosis following conservative therapy if strict diagnostic criteria are applied. Read More

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December 2019

Neuronal ceroid lipofuscinosis with cardiac involvement.

Cesk Patol 2019 ;55(3):176-181

Neuronal ceroid lipofuscinoses (NCLs) are a group of inherited neurodegenerative disorders with clinical presentation predominantly in the childhood. The NCLs represent lysosomal storage disorders characterized by the accumulation of autofluorescent lipopigment storage material. The most common clinical features include development failure, psychomotor regression, seizures, and progressive loss of vision. Read More

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December 2019

The changes of angiogenesis and immune regulations in stromal microenvironment of cutaneous melanomas.

Cesk Patol 2019 ;55(3):170-175

Tumour microenvironment contributes to growth and metastasis, where angiogenesis and immune alteration suppressing its effectory function belong to main factors. Our study is focused on an analysis of microvascular density (MVD), quantification of FOXP3+ T regulatory lymphocytes (Tregs) and PD-L1 lymphocytes, which are associated with a tumour-cells immune escape mechanism. We examined 95 cutaneous melanomas devided in four groups according to TNM classification - pT1 (35), pT2 (21), pT3 (21), pT4 (18) and 25 melanocytic nevi as a control group. Read More

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December 2019

Metanephric adenoma. A case report and literature review.

Cesk Patol 2019 ;55(3):165-169

Metanephric adenoma is a rare renal tumor with almost exclusively benign behavior, which can clinically and radiologically imitate malignancy. The histological examination is therefore crucial in diagnosis. We report a case of a 69-year-old female with an incidental finding of metanephric adenoma of the left kidney and synchronous clear cell renal cell carcinoma of the contralateral kidney. Read More

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December 2019

Histopathological assessment of the intensity and activity of the inflammation in inflammatory bowel diseases: An important addition to the endoscopy, or a pointless effort?

Cesk Patol 2019 ;55(3):158-164

Expanding amount of knowledge about inflammatory bowel diseases has changed current therapeutic goals. In the past times, the main effort of the gastroenterologists was to alleviate patients symptoms. But nowadays, one of the hot topics is a mucosal healing and achieving the endoscopic, eventually even microscopic remission. Read More

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December 2019

Cytological examination of cerebrospinal fluid.

Cesk Patol 2019 ;55(3):145-157

Cytological examination of cerebrospinal fluid (CSF) has some specifics. In the pre-analytical phase, due to collection into a tube without fixation and hypooncotic nature with rapid cell degradation, processing is required within 2-3 hours. In the subsequent analytical phase it is necessary to take into account the quantitative limit of the sample due to regular parallel cytological processing and non-morphological methods. Read More

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December 2019

Pituitary adenomas - practical approach to the diagnosis and the changes in the 2017 WHO classification.

Cesk Patol 2019 ;55(3):137-144

The histopathological diagnosis of sellar tumors is a difficult area of the diagnostic surgical pathology. The most common sellar tumor is a pituitary adenoma. The histomorphology of pituitary adenomas is very heterogeneous, and in the sellar area, we can encounter practically any other tumor known from human pathology, either primary or secondary. Read More

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December 2019

Potential use of immunohistochemistry for diagnosis precision in historic paraffin blocks.

Cesk Patol 2019 ;55(2):122-125

Authors present an autopsy case report where the immunohistochemical examination of tissues archived as paraffin blocks for more than 60 years enabled to identify the most probable primary origin of disseminated poorly differentiated adenocarcinoma. The potential issues caused by so called antigen decay and limitations of immunohistochemistry in archive material are discussed. Read More

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June 2019
18 Reads

Chronic dissecting aneurysm of ascending aorta with a large intramural thrombus and isolated aortic defects.

Cesk Patol 2019 ;55(2):115-119

We present macroscopic and microscopic findings in a case of chronic dissecting aneurysm of ascending aorta and aortic arch associated with isolated tears of aortic wall without its rupture in a 71-year-old female presenting with minimal clinical symptomatology. Aneurysmal dilation of the aorta was caused not only by the bridging of the vascular wall based on the presence of an organizing intramural thrombus in the false lumen between the separated layers, but also by a wide flat defect in the aortic intima and media with the preservation of the aortic wall integrity due to fibrotical alteration of tunica adventicia. Histologic examination of the thoracic aorta detected cystic medial degeneration with mild atherosclerosis. Read More

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June 2019
18 Reads

Cytology of Ovarian cysts.

Cesk Patol 2019 ;55(2):107-111

Ovarian cysts are often found in both the clinically predicted and the unexpected context at the current level of imaging techniques. The cytological examination of the transvaginally obtained cystic fluid can help to diagnose the nature of the cystic lesion via identification the lining structures. It is essential to distinguish functional cysts (follicular, corpusluteal) and implantation (inclusion and endometrial) from tumour cysts (dermoid, epithelial ovarian tumours, cystic metastases). Read More

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June 2019
5 Reads

Hormonal cytology.

Cesk Patol 2019 ;55(2):96-106

The spectrum of hormonal disorders of children and adolescents is broad. It reflects some current features of the advancing lifestyle and health of the population: thelarche praecox and accelerated development in young girls - early menarche, dysfunctional juvenile metrorrhagia, eating disorders - anorexia-bulimia, obesity increase, extreme sports load, autoimmune disorders, central and peripheral endocrine disorders, and others. Many of these conditions can be favorably influenced by professional lifestyle adjustments and fine hormonal medication with simultaneous monitoring of the adjusting cytogram. Read More

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June 2019
4 Reads

Cytopathology of soft tissue tumors.

Cesk Patol 2019 ;55(2):92-95

Nowadays, FNAC is an important diagnostic tool of soft tissue tumors in southeast Asia and India. We can also appreciate recent monographies on this topic authored by Swedish and American cytopathologists. They constantly stress the importance of clinical information and imaging studies. Read More

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June 2019
8 Reads

Cytology of synovial fluid.

Cesk Patol 2019 ;55(2):84-91

Examination of synovial fluid from swollen and painful joints can contribute substantially to the diagnosis of joint diseases. After a skillful arthrocentesis the sample processing must follow swiftly, because the synovial fluid can not be effectively fixed due to its viscosity. The viscosity test and cellularity assessment with particular reference to the neutrophilic granulocyte fraction, as well as the examination of the native preparation in polarized light, are some specific steps in the processing of these samples. Read More

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June 2019
24 Reads

Immunohistochemical diagnostics of Hirschprungs disease using calretinin.

Cesk Patol 2019 ;55(1):53-59

Histochemical diagnosis of Hirschsprung´s disease at our institution was introduced in the 1970s, calretinin imunohistochemistry on formalin fixed tissue was newly added in 2015. Employing both methods we were able to confirm Hirschsprung´s disease in 13 patients and exclude it in 34 patients since then. Calretinin seems highly reliable and easy to evaluate, it is not influenced by patient´s age, associated genetic features or the length of agangliosis. Read More

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June 2019
13 Reads

Noonan syndrome from a fetopathologist perspective.

Cesk Patol 2019 ;55(1):48-52

We present our experience with four cases of fetal autopsies with abnormal prenatal ultrasound findings and suspicion of Noonan syndrome. These were fetuses from the 17th to the 24th age of gestation (GA). In all cases, prenatal ultrasound examination recorded increased nuchal translucency (NT) and presence of lymphatic neck sacs. Read More

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June 2019
24 Reads

Chondroblastoma-like primary malignant giant cell tumor of the humerus - a case report.

Cesk Patol 2019 ;55(1):42-47

35-year-old woman suffered prolonged pain in the left shoulder, where an aggressively growing tumor of the proximal humerus was revealed thereafter. The lesion caused massive osteolysis of the metaepiphysis with cortical disruption, but no soft tissue extension was evident. Given the unsatisfactory effect, the ongoing neoadjuvant chemotherapy was prematurely ceased and the resection 13 cm long segment of bone with modular prosthesis replacement followed. Read More

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June 2019
26 Reads

Current status of urine cytology: What new does The Paris System for Reporting Urine Cytology bring?

Cesk Patol 2019 ;55(1):34-41

Urine cytology is used for detection of neoplastic cells in urine. It has high sensitivity and specificity in detection high-grade urothelial carcinoma, but it is low sensitive in detection of low-grade carcinoma. Different classification systems were published in the past, need for a more standardized terminology results in Paris System for Reporting Urine cytology. Read More

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June 2019
3 Reads

Cytodiagnostics in Pneumology - State of the Art 2019.

Cesk Patol 2019 ;55(1):24-33

Pulmonary cytology represents one of the basic diagnostic methods in pneumopathology. It is primarily focused on: 1) assessment of biologic nature of the pathologic process (recommended terminology and classification according to the The Papanicolaou Society of Cytopathology guidelines, 2016), 2) typing of malignant tumors (according to the WHO Classification of Tumours of the Lung, 2015), 3) assessment of mediastinal and hilar lymph nodes (including preoperative staging), 4) attaining adequate material for ancillary testing, 5) bronchoalveolar lavage (BAL) differential cell count and cytopathology studies. The need for sufficient amount of material especially in tumour diagnostics in the era of targeted therapy/personalized medicine is increasing. Read More

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June 2019
25 Reads

Current issues in fine needle aspiration biopsy of thyroid gland.

Cesk Patol 2019 ;55(1):13-23

Fine-needle aspiration biopsy (FNAB) has become an established procedure for the basic examination of thyroid nodules, which remain common in our population. The widely used Bethesda system for reporting thyroid cytopathology has undoubtedly contributed to the understanding among clinicians and cytopathologists. Since its publication in 2010, the systems overall applicability has been tested by many studies and reclassification of follicular thyroid tumours has occurred. Read More

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June 2019
4 Reads

Intravascular fasciitis leading to an aortic dissection. A case report.

Cesk Patol Fall 2018;63(4):196-199

Here we report on the case of a 61-year-old female with an accidental finding of intravascular fasciitis (IVF) affecting the ascending aorta in a specimen resected due to an acute aortic dissection. No infiltrative process of the aorta or surrounding soft tissues was grossly apparent. Microscopically, the lesion had poorly defined margins and was composed of plump spindle- and oval-shaped cells set in an abundant myxoid stroma. Read More

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April 2019
3 Reads

Hyalinizing trabecular tumor of the thyroid gland with transcapsular invasion: a case report.

Cesk Patol Fall 2018;63(4):191-194

Hyalinizing trabecular tumor is a rare neoplasm usually with benign clinical behavior. Exceptionally it shows characteristic features of malignant tumors, such as the presence of venous or capsular invasion or distant metastasis. We report the case of 45-years-old female with a palpable nodule in the right lobe of the thyroid gland, 8x8x10 mm in size, well circumscribed, white colored. Read More

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April 2019
3 Reads

Cytology of effusions in the coelom cavities.

Cesk Patol Fall 2018;63(4):175-189

oelom cavities (pleura, pericardium, peritoneum, tunica vaginalis testis) lined with mesothelial lining derived from the mesoderm, represent a frequent place of propagation of pathological processes both from the neighbourhood and primary. These are most often manifested by effusion, whose cytological examination contributes significantly to the diagnosis. Each larger amount of fluid in the coelom spaces is pathological. Read More

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April 2019
33 Reads

Carcinoma of the uterine cervix in Czech Republic and possibilities of its prevence.

Cesk Patol Fall 2018;63(4):164-168

Carcinoma of the uterine cervix belongs to significant malignancy in the Czech Republic. The goal of organized national cervical cancer screening program is to decrease incidence and mortality of this disease. Discovery of casual relationship between human papillomavirus (HPV) and cervical cancer together with modern examinations methods pushed forward possibilities of primary and secondary prevention worldwide. Read More

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April 2019
5 Reads

JOSE VEROCAY - "Pragues pathologist". The history of a Latin-American doctor.

Cesk Patol Summer 2018;54(3):147-150

José Verocay (Paysandú 1876 - Eichwald/Dubí, Bohemia 1927) was a Uruguayan anatomopathologist, recognized worldwide as "Prague's pathologist" (Fig. 1). In 1910, he described, for the first time, the morphological structure later called Verocay's bodies, which are used for diagnosing schwannoma. Read More

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April 2019
1 Read

Aberrant axillary breast tissue with pseudoangiomatous stromal hyperplasia in a man.

Cesk Patol Summer 2018;54(3):143-146

Diagnosing accessory breast tissue in a male patient is difficult when the condition is unilateral, and there is no areola or nipple. Pseudoangiomatous hyperplasia of the mammary stroma is an uncommon benign mesenchymal proliferation that may mimic low-grade angiosarcoma. We report herein an example of tumoriform pseudoangiomatous hyperplasia of the stroma arising in the accessory breast tissue of a 38-year-old man. Read More

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April 2019
26 Reads

Clinicopathological analysis of programmed death-ligand 1 testing in tumor cells of 325 patients with non-small cell lung cancer: Its predictive and potential prognostic value.

Cesk Patol Summer 2018;54(3):137-142

Introduction: Recent studies on check-point inhibitor therapy, which seems to improve the prognosis of patients with advanced non-small cell lung carcinoma increase the importance of immunohistochemical analyses of the programmed-death receptor and of its ligand, PD-L1 protein.

Material And Methods: In our study we present results of PD-L1 immunohistochemical tumor cell expression in a series of 325 lung carcinoma patients biopsies, using the clone 22C3 (and DAKO Link 48 immunostainer). Evaluation of the expression using tissue proportion scoring system allowed to distinguish negative cases (either 0 % or < 1 % of positive tumor cells) versus positive cases in the categories 1-9 %, 10-49 % and ≥ 50 % of positive tumor cells. Read More

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April 2019
18 Reads

Molecular methods for detection of prognostic and predictive markers in diagnosis of adenoid cystic carcinoma of the salivary gland origin.

Cesk Patol Summer 2018;54(3):132-136

Adenoid cystic carcinoma of salivary gland origin (AdCC) is second most common salivary carcinoma characterized by frequent recurrences, perineural invasion and high long-term mortality rate. The surgical resection of the tumor in combination with adjuvant radiotherapy is the only method of choice. AdCC has been studied, altogether with immunohistochemistry, by numerous molecular-genetic techniques. Read More

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April 2019
22 Reads

Frozen section of lung, pleura and mediastinum specimen: Retrospective analysis of 5-years practical experiences and review of the literature.

Cesk Patol Summer 2018;54(3):127-131

Thoracic frozen section biopsies including lungs, pleura and mediastinum have crucial role in differential diagnosis of solitary lesions of the lungs and mediastinum. There is a significant difference in patient´s therapeutical management, if the patients suffer from lung primary malignant tumour, metastasis or non-malignant lesion. In this review, we summarize the usefulness of frozen section biopsies in thoracic surgery and provide 5-years of experiences with thoracic frozen section biopsies performed at the Department of Pathology and Molecular Medicine of Thomayer Hospital in Prague. Read More

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April 2019
18 Reads

Intraoperative consultation in gynecologic pathology.

Cesk Patol Summer 2018;54(3):105-118

Intraoperative consultation represents an integral part of diagnostic protocols in gynecologic oncology. It may be indicated 1) to evaluate the biologic nature of a pathologic process (distinction between nonneoplastic lesions and tumors), 2) to classify the histologic type of tumor and assess its biologic behavior (typing), 3) to confirm or rule out the metastatic origin of a tumor, 4) to determine the degree of differentiation and extent of local spread of a malignant tumor (grading and staging), 5) to detect tumor deposits in lymph nodes, 6) to examine surgical resection margins, 7) to detect products of conception in uterine curettings when ectopic pregnancy is suspected and 8) to collect native tumor tissue for ancillary studies (molecular methods, flow cytometry). A frozen section of adnexal masses is commonly requested and focused primarily on the recognition of malignant tumors, the distinction between borderline tumors and carcinomas, and the identification of a metastatic process in the ovary. Read More

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April 2019
36 Reads

Results of morphological screening for Lynch syndrome during the period 2013-2016.

Cesk Patol Summer 2018;54(2):86-92

The introduction of a screening system for Lynch syndrome in pathology laboratories in Plzen yielded 24 diagnoses of Lynch syndrome during the period of 2013-2016, 20 of them presenting with colorectal cancer. In 8 of those 24 cases germline mutations of MMR genes, previously not recognized as pathogenic with certainty, were detected. Although the frequency of Lynch syndrome in patients with colorectal cancer was only 0. Read More

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April 2019
28 Reads