3,532 results match your criteria Ceska A Slovenska Oftalmologie Czech and Slovak Ophthalmology [Journal]


Prolactin and alteration of fertility.

Ceska Gynekol 2018 ;83(3):232-235

Aim: Physiology and pathology of prolactin production, clinical consequences.

Design: Review.

Setting: Reprogenesis International, Brno. Read More

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January 2018

Potential of survivin for treatment of gynaecological tumour diseases.

Ceska Gynekol 2018 ;83(3):226-231

Objective: The main purpose of this article is to consolidate known facts about survivin, its contribution to inhibition of apoptosis, impact to tumorigenesis of gynaecological types of tumours. and possibilities of inhibition of survivin on molecular-genetic levels.

Design: A review article. Read More

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January 2018

Vaccination against HPV and view of new possibilities.

Ceska Gynekol 2018 ;83(3):218-225

Objective: Overview of available information on current vaccination options against HPV and possibilities for further development.

Design: Review article.

Settings: Clinic of Gynecology and Obstetrics, University Hospital in Ostrava; Clinic of Gynecology and Obstetrics, General University Hospital in Prague. Read More

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January 2018
1 Read

Obesity and reduced fertility of men.

Authors:
M Škurla R Rybář

Ceska Gynekol 2018 ;83(3):212-217

Objective: Description of the relationship between the overweight man and the reduction of his reproductive potential.

Design: Review article.

Setting: Center of Assisted Reproduction Sanus, Jihlava. Read More

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January 2018

Planned home births in the Czech Republic, 2018.

Ceska Gynekol 2018 ;83(3):204-211

Study Aim: A summary of the current situation regarding issues of planned home births in the Czech Republic.

Type Of Study: Review and summarization. Affiliations: Department of Obstetrics and Gynecology of the Liberec regional hospital, and the Department of Obstetrics and Gynecology of the First Faculty of Medicine and General Teaching Hospital in Prague. Read More

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January 2018

Primary malignant melanoma of the vagina, case report and review of the literature.

Ceska Gynekol 2018 ;83(3):201-199

Objective: Presentation of primary malignant melanoma of the vagina. Summary of clinical findings and management.

Design: Case report. Read More

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January 2018

Robot assisted laparoscopic abdominal cerclage: two case reports.

Ceska Gynekol 2018 ;83(3):195-200

Objective: In this work we report the first use of robot-assisted preconceptual abdominal cerclage in the Czech Republic with subsequent live birth. We present two patients with a history of late pregnancy losses (late miscarriage) who underwent robotic abdominal cerclage.

Design: Case report. Read More

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January 2018

Classification of descent and mobility of urethrovesic junction in women with stress urinary incontinence - an ultrasound study.

Ceska Gynekol 2018 ;83(3):188-194

Objective: Detect urethrovesical junction descent and mobility values in women with stress incontinence prior to surgical treatment.

Design: Retrospective study.

Settings: Department of Gynecology and Obstetrics, First Medical Faculty, Charles University, General Teaching Hospital, Prague. Read More

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January 2018

Comparison of incisional and epidural analgesia in the treatment of postoperative pain after cesarean section.

Ceska Gynekol 2018 ;83(3):182-187

Objective: Comparison of incisional and epidural analgesia in the treatment of postoperative pain after cesarean sectio.

Design: Prospective cohort study in the period from 2015 to 2016.

Setting: Department of Obstetric and Gynecology, Masaryk University, University Hospital Brno. Read More

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January 2018

Does EmbryoGlue transfer medium affect embryo transfer success rate?

Ceska Gynekol 2018 ;83(3):177-181

Objective: Verification of the effect of EmbryoGlue (EG) transfer medium enriched with hyaluronan on the embryo transfer success rate.

Design: A prospective study.

Setting: Fertimed, Fertility Treatment Centre, Olomouc. Read More

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January 2018

Importance of basal fibroblast growth factor levels in patients with ovarian tumor.

Ceska Gynekol 2018 ;83(3):169-176

Objective: Evaluation of importance of serum levels of basic fibroblast growth factor (bFGF) in patients with ovarian cancer, patients with border-line ovarian tumor, patients with benign ovarian cyst and women with normal ovarian tissue.

Design: Prospective clinical study.

Setting: Department of Gynecology and Obstetrics, Charles University, Faculty of Medicine in Hradec Kralove and University Hospital Hradec Kralove. Read More

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January 2018

How durable is the effect of mirabegron in successfully-treated overactive bladder patients? Analysis of a multicentre study.

Ceska Gynekol 2018 ;83(3):164-168

Objective: Many clinical studies indicate that pharmacologic treatment of overactive bladder (OAB) is considered effective and safe, but in real clinical practice a substantial proportion of patients discontinues the treatment. The reason for discontinuing the treatment most frequently reported is lack of efficacy and/or side effects. A further significant proportion of patients reports that they stopped the treatment because the symptoms disappeared or were resolved. Read More

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January 2018

Comments on the most important and recent studies involving PCSK9i.

Authors:
Richard Češka

Vnitr Lek 2019 ;64(12):1137-1141

The paper provides a brief overview of the key studies focused on PCSK9 inhibitors. It mainly examines positive results of the FOURIER studies on evolocumab, the SPIRE study on boccocizumab and the ODYSSEY Outcomes study on alirocumab. All these studies have not only shown a significant decrease in LDL-cholesterol levels, but also the reduction of cardiovascular events just correlating with these levels. Read More

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January 2019

Consensus statement of professional associations on prescribing of PCSK9-inhibitors.

Vnitr Lek 2019 ;64(12):1131-1136

A new class of drugs known as PCSK9 inhibitors (PCSK9i) provide biological treatment for hypercholesterolemia. These drugs are administered using a subcutaneous injection once in two or four weeks. PCSK9i are not a replacement of the existing hypolipidemics, they just expand the therapeutic spectrum for the critically ill and those who cannot use the standard therapy and do not reach satisfactory target values. Read More

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January 2019
5 Reads

Cryo-EM in drug discovery.

Biochem Soc Trans 2019 Jan 15. Epub 2019 Jan 15.

Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K.

The impact of structural biology on drug discovery is well documented, and the workhorse technique for the past 30 years or so has been X-ray crystallography. With the advent of several technological improvements, including direct electron detectors, automation, better microscope vacuums and lenses, phase plates and improvements in computing power enabled by GPUs, it is now possible to record and analyse images of protein structures containing high-resolution information. This review, from a pharmaceutical perspective, highlights some of the most relevant and interesting protein structures for the pharmaceutical industry and shows examples of how ligand-binding sites, membrane proteins, both big and small, pseudo symmetry and complexes are being addressed by this technique. Read More

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http://dx.doi.org/10.1042/BST20180267DOI Listing
January 2019
1 Read

Gas chromatography-mass spectrometry study of the root and herb of Smallanthus sonchifolius.

Ceska Slov Farm 2018 ;67(4):160-163

Smallanthus sonchifolius (yacon) is a new prospective plant cultivated in Europe as a natural sugarcane substitute. It is used for diabetes and for the prevention of obesity. The study of carboxylic acids in the roots and herb of S. Read More

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January 2018
5 Reads

Study of influence of 1,3-oxazole-4-yl-phosphonic acid derivative on nitric oxide system indicators in rats with arterial hypertension.

Ceska Slov Farm 2018 ;67(4):154-159

Arterial hypertension is a leader among the most common chronic cardiovascular diseases which covers 30-45% of world population with a dynamics of further growth. 1,3-oxazole-4-yl-phosphonic acid derivative (abbreviated as oxazole derivative) is a novel original compound with vasodilating activity. The purpose of this work was to study the NO-mediated mechanism of vasodilating effect of this derivative according to the activity of eNOS, iNOS and NO2- through their content in rats on a resistant arterial hypertension model. Read More

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January 2018
1 Read

Biological role of copper as an essential trace element in the human organism.

Ceska Slov Farm 2018 ;67(4):143-153

This paper presents an overview of the physiological properties of copper (Cu), an essential trace element playing an important role in the human metabolism, primarily as a cofactor of many metalloenzymes. The maintenance of Cu homeostasis is required for proper functioning of the human body. However, when the disturbance of Cu homeostasis occurs, strong pathological manifestations may develop. Read More

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January 2018
1 Read

Pharmacy, pharmacists and drugs in the Terezín ghetto.

Ceska Slov Farm 2018 ;67(3):116-129

The article describes the phenomenon of a pharmacy in the Jewish ghetto in Terezín (Theresienstadt) in connection with the local healthcare system and the history of this ghetto. It lists the names of the Czechoslovak Jewish pharmacists who passed through this ghetto, including their fates, whether they survived or were murdered in extermination concentration camps or died as a result of the cruel living conditions in the ghetto. The article discusses the fate of the so-called Mischlingskinder ("mixed children", i. Read More

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January 2018
1 Read

Research in the chemical composition of the bark of Sorbus aucuparia.

Ceska Slov Farm 2018 ;67(3):113-115

The quantitative contents of 40 carboxylic acids, with the prevalence of hexadecanedioic, lignocerinic, behenic, azelaic, palmitic and benzoic acids, and 39 components of essential oil were determined in the extracts of the bark of Sorbus aucuparia by the GC-MS method. The quantitative contents of 6 phenolic compounds, i.e. Read More

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January 2018
2 Reads

Biosurfactants and their role in the inhibition of the biofilmforming pathogens.

Ceska Slov Farm 2018 ;67(3):107-112

Resistance of pathogenic bacteria is currently one of the major medical problems. Most microbial infections are based on the formation of biofilms, which are a significant reservoir of pathogens. The aim of this study is to determine the antibiofilm and antimicrobial activity of biosurfactants isolated from intestinal lactobacilli and marine bacteria. Read More

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January 2018
1 Read

The immunomodulatory activity of ethanolic extracts from Galium verum L. herb.

Ceska Slov Farm 2018 ;67(3):101-106

The present article discusses the results of the research into the phytochemical profile and immunomodulatory activity of Galii veri herba (Galium verum L., Rubiaceae) ethanolic extracts. The extracts under study were obtained from the plant material by means of maceration technique with 20% aqueous ethanol solution (fluid extract I), 60% aqueous ethanol solution (fluid extract II) and 96% ethanol (fluid extract III) on heating. Read More

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January 2018
3 Reads

Inflammatory bowel disease: factors involved in pathogenesis.

Ceska Slov Farm 2018 ;67(3):95-100

The incidence of inflammatory bowel disease (IBD) in developed countries increases every year. The aetiology is still not completely understood and its clarification is a key prerequisite for effective prophylaxis and therapy. IBD is most-likely caused by a combination of several factors: environmental, genetic, immunological, and disruption of intestinal microbiota composition - dysbiosis. Read More

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January 2018
7 Reads

Autosomal dominant temporal lobe epilepsy associated with heterozygous reelin mutation: 3 T brain MRI study with advanced neuroimaging methods.

Epilepsy Behav Case Rep 2019 1;11:39-42. Epub 2018 Nov 1.

Brno Epilepsy Centre, Department of Paediatric Neurology, University Hospital, Masaryk University, Brno, Czech Republic.

Purpose: Autosomal dominant lateral temporal epilepsy (ADLTE) is a genetic focal epilepsy syndrome characterized by focal seizures with dominant auditory symptomatology. We present a case report of an 18-year-old patient with acute onset of seizures associated with epilepsy. Based on the clinical course of the disease and the results of the investigation, the diagnosis of ADLTE with a proven mutation in the RELN gene, which is considered causative, was subsequently confirmed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22133232183012
Publisher Site
http://dx.doi.org/10.1016/j.ebcr.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313257PMC
November 2018
11 Reads

Lipoprotein(a), PCSK9 Inhibition and Cardiovascular Risk: Insights from the FOURIER Trial.

Circulation 2018 Nov 30. Epub 2018 Nov 30.

TIMI Study Group, Brigham and Women's Hospitalm, UNITED STATES.

Background: Lipoprotein(a) [Lp(a)] may play a causal role in atherosclerosis. Proprotein convertase subtilisin/kexin 9 (PCSK9) inhibitors have been shown to significantly reduce plasma Lp(a) concentration. However, the relationship between Lp(a) levels, PCSK9 inhibition and cardiovascular (CV) risk reduction remains undefined. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037184DOI Listing
November 2018
10 Reads

Melanoma-related changes in skin microbiome.

Folia Microbiol (Praha) 2018 Dec 15. Epub 2018 Dec 15.

Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, Vídeňská 1083, 142 20, Prague, Czech Republic.

Melanoma is the least common form of skin tumor, but it is potentially the most dangerous and responsible for the majority of skin cancer deaths. We suggest that the skin microbiome might be changed during the progression of melanoma. The aim of this study is to compare the composition of the skin microbiota between different locations (skin and melanoma) of a MeLiM (Melanoma-bearing Libechov Minipig) pig model (exophytic melanoma). Read More

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http://dx.doi.org/10.1007/s12223-018-00670-3DOI Listing
December 2018
3 Reads

Possibilities and real meaning of assessment of ovarian reserve.

Ceska Gynekol Fall 2018;83(4):307-311

Objective: To summarize the posibilities of diagnosis of diminished ovarian reserve.

Design: Survey of contemporary knowledge.

Settings: PPCHC, Sanus Jihlava; PPCHC, Sanus Hradec Králové; Reprogenesis, Brno. Read More

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January 2019
9 Reads

Late morbidity in cesarean section scar syndrome.

Ceska Gynekol Fall 2018;83(4):300-306

Objective: To summarize recent knowledge on ethiology, diagnostic management and treatment possibilities of cesarean section scar syndrome (isthmocoele).

Design: Review article.

Setting: Department of Gynaecology and Obstetrics, Faculty Hospital and Palacky University, Olomouc; Department of Gynaecology and Obstetrics, Vítkovická nemocnice, Ostrava-Vítkovice. Read More

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January 2019
8 Reads

Implantation and diagnostics of endometrial receptivity.

Ceska Gynekol Fall 2018;83(4):291-298

Objective: Literature review of endometrial receptivity in embryo implantation and its diagnostic possibilities.

Design: Literature review.

Setting: Department of Obstetrics and Gynecology, University Hospital, Faculty of Medicine, Palacky University, Olomouc; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc. Read More

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January 2019
9 Reads

Zoon vulvitis - a rare form of chronic inflammation of the vulva.

Ceska Gynekol Fall 2018;83(4):286-290

Objective: Description of finding out rare disease Zoon vullvitis. Desing: Case report and differential diagnosis.

Setting: Department of Obstetric and Gynecology, University Hospital Ostrava. Read More

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January 2019
1 Read

Acute enteroviral meningoencephalitis as unusual cause of diplopia in pregnancy and puerperium.

Ceska Gynekol Fall 2018;83(4):281-285

Objective: To describe unusual cause of diplopia in early puerperal period.

Design: Case report.

Setting: Department of Obstetrics and Gynecology, 2nd Faculty of Medicine and Faculty Hospital Motol. Read More

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January 2019
1 Read

Nerozpoznaná preeklampsie, která se rozvinula do eklamptického záchvatu s fatálním koncem.

Ceska Gynekol Fall 2018;83(4):276-280

Objective: A fatal case of a 37 year old women in the fifth month of pregnancy, who showed no signs of life and who could not be revived is reported.

Design: Case report.

Settings: Forensic expert in healthcare, Liberec; Department of Health Care Disciplines and Population Protection, Faculty of Biomedical engineering, Czech Technical University in Prague; Department of Biology, Faculty of Education, J. Read More

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January 2019
9 Reads

A rare complication of long-term vaginal prolapse.

Ceska Gynekol Fall 2018;83(4):271-275

Objective: Description of rare complication of long-term uterine prolaps. Desing: Case report.

Setting: Department of Obstetric and Gynecology, University Hospital Ostrava. Read More

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January 2019
4 Reads

The role of hormonal therapy in patients with uterine carcinoma.

Ceska Gynekol Fall 2018;83(4):263-270

Objective: The aim of the study was to describe the role of hormonal therapy in the treatment of malignant uterine tumors, indications, the effect of the treatment and to verify its safety in our study cohort. We also present an overview of recent studies on that topic.

Design: Unicentric retrospective observational study and review of recent literature. Read More

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January 2019
6 Reads

How accurate are we in urethral mobility assessment? Comparison of subjective and objective assessment.

Ceska Gynekol Fall 2018;83(4):257-262

Objective: The knowledge of the mobility of urethra plays important role in patients with stress urinary incontinence and its assessment is a part of standard urogynecological examination. It has been assumed that increased mobility is associated with higher likelihood of successful treatment. There is arbitrary defined cut-off for hypermobile urethra - descend of more than 15 mm or 30-degree resp. Read More

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January 2019
15 Reads

Comparison of groups with medical and surgical terminations of pregnancy.

Ceska Gynekol Fall 2018;83(4):244-249

Objective: The aim of this study was to compare two cohorts of subjects who underwent termination of pregnancy up to 49 days of amenorrhoea by medical (pharmacological) termination (faUUT) and surgical instrumental termination of pregnancy (inUUT).

Design: Prospective clinical study.

Setting: Department of Gynecology and Obstetrics, Charles University in Prague, 1st Faculty of Medicine, Hospital Na Bulovce. Read More

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January 2019
2 Reads

Effects of tapeworm infection on absorption and excretion of zinc and cadmium by experimental rats.

Environ Sci Pollut Res Int 2018 Dec 22;25(35):35464-35470. Epub 2018 Oct 22.

Department of Zoology and Fisheries, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences, Kamýcká 957, 165 21, Prague 6, Suchdol, Czech Republic.

The main objective of this study was to determine how rat tapeworms affect the excretion of zinc and cadmium through rat feces. Male rats (Rattus norvegicus var. alba) were divided into four groups, and the experiment was conducted over a 6-week period. Read More

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http://link.springer.com/10.1007/s11356-018-3397-9
Publisher Site
http://dx.doi.org/10.1007/s11356-018-3397-9DOI Listing
December 2018
11 Reads

Body Adiposity Changes After Lifestyle Interventions in Children/Adolescents and the NYD-SP18 and TMEM18 Variants.

Med Sci Monit 2018 Oct 20;24:7493-7498. Epub 2018 Oct 20.

Dr. Filip's Institute for Children, Poděbrady, Czech Republic.

BACKGROUND This study was carried out to determine the relationship between the common TMEM-18 (rs4854344, G>T) and NYD-SP18 (rs6971091, G>A) gene variants and weight loss after lifestyle interventions (increased physical activity in conjunction with optimal dietary intake) in overweight/obese children/adolescents. MATERIAL AND METHODS We genotyped 684 unrelated, white, non-diabetic children (age 12.7±2. Read More

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http://dx.doi.org/10.12659/MSM.907180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204654PMC
October 2018
4 Reads

[Extracapsular Proximal Femoral Fractures - Retrospective Evaluation of a Group of Patients with a Focus on Complications of Treatment].

Acta Chir Orthop Traumatol Cech 2018 ;85(4):249-253

Fakulta vojenského zdravotnictví Univerzity obrany, Hradec Králové, Česká republika.

PURPOSE OF THE STUDY The purpose of this study is to retrospectively evaluate the treatment and the complications in patients with extracapsular proximal femoral fractures. MATERIAL AND METHODS The evaluation focused on a group of patients who underwent a surgery at the authors department in the period from 1 January 2011 to 31 December 2013. The inclusion criteria were a simple fall and a monotrauma. Read More

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January 2019
3 Reads

Enchiridion medicinae by Georg Henisch (1549-1618).

Ceska Slov Farm 2018 ;67(2):85-90

Georg Henisch (1549-1618), a native of Bardejov, for all of his life as a teacher at St. Anne's Grammar School in Augsburg, Germany. He was a very prolific polyhistor, publishing spiritual and occasional poetry, works on medicine, mathematics, rhetoric, dialectics, astronomy, linguistics and geography, editions of some ancient authors, and several translations. Read More

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January 2018
1 Read

On the content of the National part of the Czech Pharmacopoeia 2017.

Ceska Slov Farm 2018 ;67(2):81-84

This paper deals with the content of the national part of the Czech Pharmacopoeia (CP) 2017 in terms of preparation of pharmaceuticals in pharmacies, quantitative methods for controlling their quality and their usable life. Despite the longer time span of the CP 2017 since the CP 2009, compared to the CP 2009 from the CP 2005, the content of the CP 2017 can not be evaluated as a more pronounced shift from the national part of the CP 2009. Some issues of the national section of the CP 2017 are discussed in detail in the paper. Read More

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January 2018
12 Reads

Microbiome in connection with metabolic syndrome and the therapeutic potential of its influencing.

Ceska Slov Farm 2018 ;67(2):71-80

Several fields of medicine have been concerned with the role of the microbiome in maintaining the balance in the human body and its changes in the pathogenesis of diseases in recent years. The intestinal microbiome seems to play a key role in the regulation of metabolic pathways, inflammation and intestinal permeability. The aim of this review is to assess the importance of the intestinal microbiome in metabolic syndrome and the therapeutic or preventive potential of its manipulation. Read More

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January 2018
2 Reads

Selenium in the prevention and subsidiary therapy of cancer of soft tissues.

Ceska Slov Farm 2018 ;67(2):66-70

Selenium as an antioxidant has attracted attention because of its anticancer activity. This review presents a view on selenium and its compounds exerting influence against cancer in the soft tissues. The results reveal a significant strong association between a low selenium level in blood and a cancer risk. Read More

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January 2018
2 Reads

Superdisintegrants used in pharmaceutical technology.

Authors:
Jan Gajdziok

Ceska Slov Farm 2018 ;67(2):59-65

Disintegrants are substances which promote disintegration of the solid dosage form in the dissolution medium or body fluids. Efficient disintegration is an important prerequisite for ensuring release of the active substance and its good bioavailability. Several mechanisms of disintegrants´ action are currently recognized, but disintegration is a complex process, and the majority of substances act by combining multiple mechanisms. Read More

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January 2018
13 Reads

Melatonin as a structural template in the development of novel drugs for neurodegenerative disorders.

Authors:
Jan Korábečný

Ceska Slov Farm 2018 ;67(2):51-58

Melatonin is a key regulatory hormone produced mainly in the pineal gland. In the recent years, melatonin contribution to neurodegenerative disorders has dramatically increased when inspecting its favorable pharmacological profile. Its levels were found to be decreased during aging. Read More

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January 2018
12 Reads

Pharmacy and Johann Wolfgang von Goethe: Pharmacists as Goethes chemistry teaches.

Ceska Slov Farm 2018 ;67(1):32-44

At the turn of the 18th and 19th centuries, when pharmacy was established as a modern scientific discipline, pharmacists played an important role in spreading the latest discoveries in the field of chemistry, being virtually the only established representatives of the field. The article focuses on a mutually enriching dialogue between the prominent personality of the time - the poet, writer and statesman, as well as the scientist - Johann Wolfgang von Goethe and the major representatives of the pharmacy of that time, especially J. R. Read More

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January 2018
2 Reads

Theory and practice of pharmacopoeial control of the quality of drugs and excipients VII. The colour reference solutions of the European pharmacopoeia (Ph. Eur.).

Ceska Slov Farm 2018 ;67(1):30-31

Data calculations of three different workplaces consistently show that the difference in colour ΔE (CIELAB) of some colour reference solutions according to Ph. Eur. with small colour and purified water are too small. Read More

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January 2018
11 Reads

The immunomodulatory activity of the extracts and complexes of biologically active compounds of Galium verum L. herb.

Ceska Slov Farm 2018 ;67(1):25-29

The present article discusses the results of an immunomodulatory activity of Galii veri herba, Galium verum herb (Galium verum L., Rubiaceae) fluid water extract and the effect of the polysaccharide and phenolic complexes of the letter on the immunomodulatory activity. The same extract was fractionated into a polysaccharide complex (PSC) and a polyphenolic complex (PPC). Read More

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January 2018
1 Read

Liberalization and integration of drug distribution in the EU 28 and Norway.

Ceska Slov Farm 2018 ;67(1):14-24

The pharmaceutical distribution system in Europe is undergoing a long-term change. Wholesale companies join together to form both horizontally and vertically integrated structures. Pharmacies, formerly owned almost exclusively by pharmacists, are becoming part of the chain thanks to the liberalization of operating conditions. Read More

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January 2018
2 Reads

Genistein: a promising molecule modulating tumour growth and wound healing?

Ceska Slov Farm 2018 ;67(1):3-13

Although it has been shown that oestrogen replacement therapy is able to improve wound healing, several side effects of this replacement therapy have precluded its common use in clinical practice. On the other hand, the phytoestrogen genistein (the selective oestrogen receptor modulator belonging to the group of isoflavones) has been introduced into several clinical trials to improve cancer treatment efficiency and experiments suggest its positive effect on wound healing. The main mechanisms of action, which have been elucidated so far, include induction of apoptosis, cell cycle arrest, inhibition of angiogenesis and tyrosine kinase activity as well as cancer chemoprevention and reduction of climacteric symptoms. Read More

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January 2018
1 Read