80,446 results match your criteria Cervix Cancer


Barriers and facilitators of follow-up among women with precancerous lesions of the cervix in Cameroon: a qualitative pilot study.

Int J Womens Health 2019 1;11:229-239. Epub 2019 Apr 1.

College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA, USA,

Purpose: This pilot study explores the barriers to adherence to follow-up among women with cervical precancer in urban Cameroon. While follow-up of women with a positive screening of cervical precancer is the most important aspect of cervical cancer secondary prevention, women with cervical precancer do not adhere frequently to recommended follow-up schedule in Cameroon. The aim of the study was to explore and describe the barriers and facilitators to follow-up for cervical precancer among women infected and uninfected with HIV in Cameroon. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/IJWH.S196112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448541PMC

Pancreatic Metastasis from Adenocarcinoma of the Uterine Cervix.

Korean J Gastroenterol 2019 Mar;73(3):182-185

, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Korea.

Pancreatic metastasis from cervical cancer is extremely rare. We report a case of metastatic adenocarcinoma of the pancreas from uterine cervical cancer. A 70-year-old woman was referred because of a pancreatic mass detected by CT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4166/kjg.2019.73.3.182DOI Listing

Synthesis and antiproliferative activity of novel (+)- usnic acid analogues.

J Asian Nat Prod Res 2019 Apr 23:1-16. Epub 2019 Apr 23.

b Applied Biology Department , CSIR-Indian Institute of Chemical Technology , Hyderabad 500007 , India.

Twenty one novel (+)- usnic acid-based analogues belonging to three classes such as enamines, imines, and pyrazoles were synthesized. All the synthesized compounds were characterized by their spectral data (H NMR, C NMR, IR, and HRMS). The synthesized compounds were evaluated for their antiproliferative activity against a panel of four human cancer cell lines including HeLa (cervix), MDA-MB-231 (breast), A549 (lung), and MiaPaca (pancreas) by employing SRB cell proliferation assay. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10286020.2019.1603220DOI Listing

Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis.

Cancer Res Treat 2019 Apr 19. Epub 2019 Apr 19.

Department of Pathology & Cancer Research Center, Yanbian University Medical College, Yanji, China.

Purpose: This study was aimed to investigate the role of poly(A)-binding protein-interacting protein 1 (Paip1) in cervical carcinogenesis.

Materials And Methods: The expression of Paip1 in normal cervical epithelial tissues and cervical cancer (CC) tissues were detected by Immunohistochemistry. In vivo and in vitro assays were performed to validate effect of Paip1 on CC progression. Read More

View Article

Download full-text PDF

Source
http://www.e-crt.org/journal/view.php?doi=10.4143/crt.2018.5
Publisher Site
http://dx.doi.org/10.4143/crt.2018.544DOI Listing
April 2019
1 Read

[Acceptability of human papilloma virus vaccine: parent survey].

Pan Afr Med J 2018 2;31:71. Epub 2018 Oct 2.

Service de Pédiatrie A, CHU Mohammed VI, Marrakech, Faculté de Médecine et de Pharmacie, Université Cadi Ayyad, Marrakech, Maroc.

This study aims to evaluate the extent of human papilloma virus vaccine awareness among parents of girls in vaccine age group, their acceptability of the vaccine and factors associated with refusal. We conducted a survey among parents of girls aged 8-15 years, followed-up for several diseases in the Department of Pediatrics at the University Hospital Mohamed VI in Marrakech, Morocco, on parents' profile, their awareness of cancer of the cervix, HPV and HPV vaccine, the acceptance of HPV vaccine for their daughters and the arguments related to refusal. Ninety six questionnaires were included in the analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11604/pamj.2018.31.71.15400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457735PMC
October 2018

FIGO Stage Is the Strongest Prognostic Factor in Adenocarcinoma of the Uterine Cervix.

J Obstet Gynaecol Can 2019 Apr 19. Epub 2019 Apr 19.

Department of Obstetrics and Gynecology, Cumming School of Medicine, University of Calgary, Calgary, AB; Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB; Calgary Laboratory Services, Calgary, AB.

Objective: This study aimed to identify clinical and pathological determinants of invasive adenocarcinoma of the uterine cervix (AC) in a large, single-centre series serving a population of 1.5 million.

Methods: Data on clinical (n = 27) and pathological (n = 23) variables for 166 women with a diagnosis of AC treated between 2000 and 2013 were extracted from their charts and pathology reports. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S17012163193008
Publisher Site
http://dx.doi.org/10.1016/j.jogc.2019.01.026DOI Listing
April 2019
1 Read

[Effects of hnRNP E1 and both early genes E2 and E6 of HPV16 together with their interactions on cervical carcinogenesis].

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Apr;40(4):466-470

Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China.

To explore the effects of hnRNP E1 and both early genes E2 and E6 of HPV16 as well as their interactions in the progression of cervical carcinogenesis. Subjects of this study included 56 women with normal cervix (NC), 58 patients with low-grade cervical intraepithelial neoplasm (CINⅠ) and 50 patients with high-grade cervical intraepithelial neoplasm (CINⅡ/Ⅲ) who were all recruited from the 'Cervical Lesions Study Cohort Project' in Jiexiu of Shanxi province from June to September, 2014. Another 40 patients with cervical squamous cell carcinoma (SCC) were from the Shanxi Tumor Hospital during the same period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2019.04.018DOI Listing

Nodal failure after chemo-radiation and MRI guided brachytherapy in cervical cancer: Patterns of failure in the EMBRACE study cohort.

Radiother Oncol 2019 May 26;134:185-190. Epub 2019 Feb 26.

Department of Radiation Oncology, University Medical Center Utrecht, the Netherlands. Electronic address:

Purpose/objective(s): To investigate the patterns of nodal failure in patients enrolled in the international multicentre EMBRACE study.

Materials/methods: Nodal disease at diagnosis (N-, N+) and nodal failure were analysed per region (NF) (pelvic (parametrial, common iliac, internal/external iliac), inguinal and para-aortic (PAO)) in 1338 patients. Treatment consisted of chemo-radiation and MRI guided brachytherapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.radonc.2019.02.007DOI Listing

Cytotoxicity screening of supercritical fluid extracted seaweeds and phenylpropanoids.

Mol Biol Rep 2019 Apr 19. Epub 2019 Apr 19.

Department of Bioengineering, Faculty of Engineering, Ege University, 35100, Bornova, Izmir, Turkey.

Detached leaves of Posidonia oceanica and Zostera marina creating nuisance at the shores were extracted by means of supercritical CO enriched with a co-solvent, compared with that of soxhlet extraction. The extracts and their active compounds which are phenylpropanoids (chicoric, p-coumaric, rosmarinic, benzoic, ferulic and caffeic acids) were screened for cytotoxicity in cancer cell lines including human breast adenocarcinoma (MCF-7, MDA-MB-231, SK-BR-3), human colon adenocarcinoma (HT-29), human cervix adenocarcinoma (HeLa), human prostate adenocarcinoma (PC-3), Mus musculus neuroblastoma (Neuro 2A) cell lines and African green monkey kidney (VERO) as healthy cell line. Supercritical CO extracts proved to be more active than soxhlet counterparts. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11033-019-04812-9
Publisher Site
http://dx.doi.org/10.1007/s11033-019-04812-9DOI Listing
April 2019
1 Read

Immunotherapy of gynecological cancers.

Best Pract Res Clin Obstet Gynaecol 2019 Mar 21. Epub 2019 Mar 21.

Division of Gynecologic Oncology, Segal Cancer Center, Lady Davis Institute of Research, Jewish General Hospital, McGill University, Montreal, Canada. Electronic address:

Oncology treatments have evolved from intuitive, via empiric, to the present precision medicine, with the integration of molecular targeted therapies in our treatment arsenal. The use of the patients' powerful immune system has long been contemplated and recently led to the integration of immunotherapy to overturn the well-documented inhibitory effects of the tumor on the immune system and restore it to a state of activity against the cancer. Recent favorable results have shown the value and effectiveness of immunotherapy against gynecological cancers. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15216934193003
Publisher Site
http://dx.doi.org/10.1016/j.bpobgyn.2019.03.005DOI Listing
March 2019
1 Read

Innervation of cervical carcinoma is mediated by cancer-derived exosomes.

Gynecol Oncol 2019 Apr 16. Epub 2019 Apr 16.

Sanford Research, Cancer Biology and Immunotherapy Group, 2301 East 60th St north, Sioux Falls, SD 57104, USA. Electronic address:

Objective: Recently, our laboratory identified sensory innervation within head and neck squamous cell carcinomas (HNSCCs) and subsequently defined a mechanism whereby HNSCCs promote their own innervation via the release of exosomes that stimulate neurite outgrowth. Interestingly, we noted that exosomes from human papillomavirus (HPV)-positive cell lines were more effective at promoting neurite outgrowth than those from HPV-negative cell lines. As nearly all cervical tumors are HPV-positive, we hypothesized that these findings would extend to cervical cancer. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00908258193114
Publisher Site
http://dx.doi.org/10.1016/j.ygyno.2019.04.651DOI Listing
April 2019
2 Reads
3.774 Impact Factor

Synthesis of New Derivatives of Benzofuran as Potential Anticancer Agents.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Łódź, Poland.

The results of our previous research indicated that some derivatives of benzofurans, particularly halogeno-derivatives, are selectively toxic towards human leukemia cells. Continuing our work with this group of compounds we here report new data on the synthesis as well as regarding the physico-chemical and biological characterization of fourteen new derivatives of benzofurans, including six brominated compounds. The structures of all new compounds were established by spectroscopic methods (H- and, C-NMR, ESI MS), and elemental analyses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules24081529DOI Listing

What is needed now for successful scale-up of screening?

Papillomavirus Res 2019 Apr 16;7:173-175. Epub 2019 Apr 16.

PATH, Seattle, USA.

Effective screening for pre-cancerous lesions of the cervix is the only protective intervention that can be offered to women that have not had the opportunity to be vaccinated. Elimination goals are being developed so that by 2030, 70% of women aged 35-45 years should have been screened at least once in a lifetime and 90% of all detected lesions should have been treated. These goals focus on a substantial reduction of cervical cancer burden in low- and middle-income countries (LMICs). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S24058521193003
Publisher Site
http://dx.doi.org/10.1016/j.pvr.2019.04.011DOI Listing
April 2019
2 Reads

Over Expressed TKTL1, CIP-2A, and B-MYB Proteins in Uterine Cervix Epithelium Scrapings as Potential Risk Predictive Biomarkers in HR-HPV-Infected LSIL/ASCUS Patients.

Front Oncol 2019 3;9:213. Epub 2019 Apr 3.

Human Histology and Embryology Unit, University of Verona Medical School, Verona, Italy.

High oncogenic risk human papillomaviruses (HR-HPVs) promote cervical carcinoma development, the fourth most common feminine cancer. A slow oncodevelopmental phase-defined histopathologically as Cervical Intraepithelial Neoplasia (CIN) grades 1-3, or cytologically as Low- or High-grade Squamous Intraepithelial Lesions (LSIL or HSIL)-precedes the malignancy. Cervical carcinoma screenings through HR-HPV genotyping and Pap smears are regularly performed in Western countries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2019.00213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456695PMC

Role of apparent diffusion coefficient as a biomarker in the evaluation of cervical cancer.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):25-32

Department of Radiation Oncology, Command Hospital (Central Command), Lucknow, Uttar Pradesh, India.

Background: Diffusion-weighted magnetic resonance imaging (DW-MRI) has evolved as a major diagnostic and prognostic tool in cervical cancer. The aim of our study was to compare the change in mean apparent diffusion coefficient (ADC) value before and after concurrent chemoradiation therapy (CCRT) in carcinoma cervix thereby establishing its role as a cancer biomarker.

Materials And Methods: A hospital-based prospective study was conducted in 35 patients diagnosed with cervical cancer. Read More

View Article

Download full-text PDF

Source
http://www.ijri.org/text.asp?2019/29/1/25/255235
Publisher Site
http://dx.doi.org/10.4103/ijri.IJRI_441_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467043PMC
April 2019
1 Read

Fluorodeoxyglucose Positron Emission Tomography integrated with computed tomography in carcinoma of the cervix: Its impact on accurate staging and the predictive role of its metabolic parameters.

PLoS One 2019 18;14(4):e0215412. Epub 2019 Apr 18.

Department of Nuclear Medicine, University of Pretoria, Pretoria, South Africa.

Objectives: To determine the impact of FDG-PET/CT in the initial staging of cervical cancer among women with and without HIV and to determine the abilities of FDG-PET/CT metabolic parameters in predicting the presence of distant metastasis.

Methods: We reviewed the FDG-PET/CT images of women with FIGO stage IB2 to IVA carcinoma of the cervix. We compared the FIGO stage before and after FDG-PET/CT. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215412PLOS
April 2019
2 Reads

Radiation induces changes in toll-like receptors of the uterine cervix of the rat.

PLoS One 2019 18;14(4):e0215250. Epub 2019 Apr 18.

Department of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Radiotherapy is an important therapeutic approach against cervical cancer but associated with adverse effects including vaginal fibrosis and dyspareunia. We here assessed the immunological and oxidative responses to cervical irradiation in an animal model for radiation-induced cervicitis. Rats were sedated and either exposed to 20 Gy of ionising radiation given by a linear accelerator or only sedated (controls) and euthanized 1-14 days later. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215250PLOS
April 2019
5 Reads

Estimated Number of Cases of High-Grade Cervical Lesions Diagnosed Among Women - United States, 2008 and 2016.

MMWR Morb Mortal Wkly Rep 2019 Apr 19;68(15):337-343. Epub 2019 Apr 19.

Human papillomavirus (HPV) causes approximately 30,000 cancers in the United States annually (1). HPV vaccination was introduced in 2006 to prevent HPV-associated cancers and diseases (1). Cervical cancer is the most common HPV-associated cancer in women (1). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15585/mmwr.mm6815a1DOI Listing

Implementing a central composite design for the optimization of solid phase microextraction to establish the urinary volatomic expression: a first approach for breast cancer.

Metabolomics 2019 Apr 17;15(4):64. Epub 2019 Apr 17.

CQM-Centro de Química da Madeira, Universidade da Madeira, Campus Universitário da Penteada, 9020-105, Funchal, Portugal.

Introduction: Breast cancer (BC) is positioned as the second among all cancers remaining at the top of women´s diseases worldwide followed by colorectum, lung, cervix, and thyroid cancers. The main drawback of most the screening/diagnostic methods is their low sensitivity/specificity and in some cases the invasive procedure required to obtain the samples.

Objectives: On the present investigation, we report a statistical design was to evaluate by central composite design the influence towards the optimization of the most significant variables of solid-phase microextraction (SPME) procedure for the isolation of volatile organic metabolites (VOMs) from urine of BC patients (N = 31) and healthy individuals (CTL; N = 40). Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11306-019-1525-2
Publisher Site
http://dx.doi.org/10.1007/s11306-019-1525-2DOI Listing
April 2019
9 Reads

Health service delivery models for scaling use of point-of-care HPV 'test and treat' strategies in high-burden, low-income settings.

J Virus Erad 2019 Mar 4;5(Suppl 1):1-3. Epub 2019 Mar 4.

Papua New Guinea Collaborative Research Program in Sexual and Reproductive Health, Papua New Guinea Institute of Medical Research (PNG IMR); Kirby Institute, University of New South Wales, Sydney, Australia.

Visual inspection of the cervix with acetic acid (VIA) has shown disappointing performance when used alone as part of screen and treat strategies for cervical cancer prevention in Papua New Guinea. Point-of-care testing with the Xpert® HPV assay (Cepheid, Sunnyvale, CA, USA) offers a new approach, enabling 'test and treat' services using self-collected specimens with same-day curative cervical ablation (cryotherapy or thermocoagulation). Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428153PMC
March 2019
3 Reads

Label-free target identification reveals oxidative DNA damage as the mechanism of a selective cytotoxic agent.

Chem Sci 2019 Mar 19;10(12):3449-3458. Epub 2019 Feb 19.

CRI Center for Chemical Proteomics , Department of Chemistry , Seoul National University , Seoul 08826 , Korea.

Phenotypic screening can not only identify promising first-in-class drug candidates, but can also reveal potential therapeutic targets or neomorphic functions of known proteins. In this study, we identified target proteins of SB2001, a cytotoxic agent that acts specifically against HeLa human cervical cancer cells. Because SB2001 lacks chemical modification sites, label-free target identification methods including thermal stability shift-based fluorescence difference in two-dimensional gel electrophoresis (TS-FITGE) and thermal proteome profiling (TPP) were applied to characterize its mechanism of action. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8sc05465gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438152PMC
March 2019
1 Read

Syphilitic Cervicitis with Cervical Cancer Presenting as Oropharyngeal Syphilis: A Case Report.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of General Internal Medicine, Akashi Medical Center, Japan.

We herein report a patient with syphilitic cervicitis and cervical cancer presenting as oropharyngeal syphilis. A 31-year-old Japanese woman with a history of unprotected vaginal and oral sex visited our hospital with right submandibular adenomas and erythema in the extremities. The fornix uteri was red, with a nodule noted. Read More

View Article

Download full-text PDF

Source
https://www.jstage.jst.go.jp/article/internalmedicine/advpub
Publisher Site
http://dx.doi.org/10.2169/internalmedicine.2426-18DOI Listing
April 2019
2 Reads

Pathway to the Papanicolaou smear: The development of cervical cytology in twentieth-century America and implications in the present day.

Gynecol Oncol 2019 Apr 14. Epub 2019 Apr 14.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, United States of America.

George Papanicolaou, a Greek immigrant and cytopathologist, was responsible for what is now colloquially known as the "Pap smear"-undoubtedly one of the greatest advances in medicine and public health of the last century. However, his landmark research on the development of cervical cytology for the detection of precancerous lesions of the cervix ("New Cancer Diagnosis," 1928) made a rather inauspicious debut in an unlikely venue: John Harvey Kellogg's Third Race Betterment Conference-a meeting devoted to the furtherance of the concept and implementation of eugenics. Herein, we discuss the stark juxtaposition of Papanicolaou's landmark discovery amid the pseudoscience of the third Race Betterment Conference. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ygyno.2019.04.004DOI Listing
April 2019
1 Read

A Comparative Study for Selectivity of Micronuclei in Cervical Exfoliated Cells on Chronic Boron Effects.

J Cytol 2019 Apr-Jun;36(2):75-78

Department of Medical Biology, School of Medicine, Faculty of Health Sciences, Manisa Celal Bayar University, Manisa, Turkey.

Background: Cervical cancer is one of the most frequent malignancies in women. Micronucleus (MN) testing has gained popularity as a biomarker in early diagnosis of many types of cancer.

Aims: This study aims to investigate the role of MN testing on early detection of cervical cancer and the effect of boron exposure on cervical cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/JOC.JOC_185_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425774PMC
April 2019
1 Read

Constitutively active ESR1 mutations in gynecologic malignancies and clinical response to estrogen-receptor directed therapies.

Gynecol Oncol 2019 Apr 13. Epub 2019 Apr 13.

Duke University Medical Center, Durham, NC, United States of America.

Objective: Endocrine therapy is often considered as a treatment for hormone-responsive gynecologic malignancies. In breast cancer, activating mutations in the estrogen receptor (mutESR1) contribute to therapeutic resistance to endocrine therapy, especially aromatase inhibitors (AIs). The purpose of this study was to evaluate the frequency and clinical relevance of ESR1 genomic alterations in gynecologic malignancies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ygyno.2019.04.010DOI Listing
April 2019
1 Read

Survey of cervical cancer and precancerous lesion prevention knowledge within community health service centers in Shanghai, China.

Medicine (Baltimore) 2019 Apr;98(15):e15002

To study deficiencies in knowledge of the general public health-care professionals in community health service centers regarding the prevention of cervical intraepithelial neoplasia and cervical cancer. In addition, this study examined the key content of training required for primary health-care personnel to prevent cervical precancerous lesion and cervical cancer.A questionnaire was distributed among 172 medical staff personnel (the ratio of general practitioners and nurses was 1:1 in five community health service centers in Shanghai, China. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000015002DOI Listing
April 2019
2 Reads

Metastases to the breast, an uncommon diagnosis: what do radiologists need to know?

Radiologia 2019 Apr 10. Epub 2019 Apr 10.

Servicio de Anatomía Patológica, Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.

Objective: To analyze the imaging characteristics of histologically diagnosed metastases to the breast.

Material And Methods: We selected patients histologically diagnosed with metastases to the breast in our diagnostic and interventional breast imaging unit between March 2010 and September 2018.

Results: A total of 9 patients (all women; mean age, 60 y; age range, 28-89 y) were diagnosed with metastases to the breast. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00338338193003
Publisher Site
http://dx.doi.org/10.1016/j.rx.2019.02.004DOI Listing
April 2019
2 Reads

Sentinel lymph node biopsies in endometrial cancer - practice patterns among Gynecologic Oncologists in the United States.

J Minim Invasive Gynecol 2019 Apr 10. Epub 2019 Apr 10.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Stanford University School of Medicine. Electronic address:

Study Objective: To evaluate practice patterns among gynecologic oncologists with regards to sentinel lymph node injection and biopsy in endometrial cancer.

Design: Observational study with no control group.

Setting And Patients: Active members of the Society of Gynecologic Oncology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmig.2019.04.006DOI Listing
April 2019
1.575 Impact Factor

Octamer binding transcription factor-4 expression is associated with cervical cancer malignancy and histological differentiation: A systematic review and meta-analysis.

Biosci Rep 2019 Apr 12. Epub 2019 Apr 12.

Department of Gastroenterology, Taihe Hospital, Shiyan, Washington, 442012, China

Objective: The relationship between the expression of octamer binding transcription factor 4  (OCT-4) and clinicopathological features of cervical cancer (CC) is evaluated in detail.

Methods: The findings on the relationship collected by retrieving PubMed, EMBASE, Cochrane library, Wan Fang and Chinese National Knowledge Infrastructure(CNKI) databases results and tracing back to the literature and published in public, which began in setting up the literature database and ended in May 2018. The literatures are screened, extracted and evaluated according to the inclusion and exclusion criteria, and meta-analysis was carried out via RevMan 5. Read More

View Article

Download full-text PDF

Source
http://bioscirep.org/lookup/doi/10.1042/BSR20182328
Publisher Site
http://dx.doi.org/10.1042/BSR20182328DOI Listing
April 2019
3 Reads

Fibronectin promotes cervical cancer tumorigenesis through activating FAK signaling pathway.

J Cell Biochem 2019 Apr 11. Epub 2019 Apr 11.

Department of Obstetrics and Gynecology, Suzhou Traditional Chinese and Western Medicine Hospital, Suzhou, China.

Cervical cancer is a cancer arising from the cervix, and it is the fourth most common cause of death in women. Overexpression of fibronectin 1 (FN1) was observed in many tumors and associated with the survival and metastasis of cancer cells. However, the mechanism by which FN1 promotes cervical cancer cell viability, migration, adhesion, and invasion, and inhibits cell apoptosis through focal adhesion kinase (FAK) signaling pathway remains to be investigated. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28282
Publisher Site
http://dx.doi.org/10.1002/jcb.28282DOI Listing
April 2019
8 Reads

Refining our understanding of cervical neoplasia and its cellular origins.

Papillomavirus Res 2019 Apr 8. Epub 2019 Apr 8.

Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge, CB2 1QP, UK.

Human papillomaviruses (HPV) cause cancer at a number of vulnerable epithelial sites, including the cervix, the anus and the oropharynx, with cervical cancer being the most significant in terms of numbers. The cervix has a complex epithelial organisation, and comprises the stratified epithelium of the ectocervix, the columnar epithelium of the endocervix, and the cervical transformation zone (TZ). Most cervical cancers arise at the TZ, which is a site where a stratified squamous epithelium can develop via metaplasia from a simple columnar epithelium. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pvr.2019.04.005DOI Listing
April 2019
1 Read

Immunologic Consequences of Sequencing Cancer Radiotherapy and Surgery.

JCO Clin Cancer Inform 2019 Apr;3:1-16

3 Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

Purpose: Early-stage cancers are routinely treated with surgery followed by radiotherapy (SR). Radiotherapy before surgery (RS) has been widely ignored for some cancers. We evaluate overall survival (OS) and disease-free survival (DFS) with SR and RS for different cancer types and simulate the plausibility of RS- and SR-induced antitumor immunity contributing to outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/CCI.18.00075DOI Listing
April 2019
1 Read

HPV73 a non-vaccine type causes cervical cancer.

Int J Cancer 2019 Apr 9. Epub 2019 Apr 9.

Department of Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Ave, Ullmann Building, Room 515, Bronx 10461, New York, USA.

HPV73 is classified as possibly oncogenic. It is neither routinely evaluated in HPV screening, nor covered by any of the prophylactic vaccines. We sought to investigate the carcinogenic characteristics of HPV73. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32315
Publisher Site
http://dx.doi.org/10.1002/ijc.32315DOI Listing
April 2019
2 Reads

FightHPV: Design and Evaluation of a Mobile Game to Raise Awareness About Human Papillomavirus and Nudge People to Take Action Against Cervical Cancer.

JMIR Serious Games 2019 Apr 8;7(2):e8540. Epub 2019 Apr 8.

HPV Research Group, Department of Research, Cancer Registry of Norway, Oslo, Norway.

Background: Human papillomavirus (HPV) is the most common sexually transmitted infection globally. High-risk HPV types can cause cervical cancer, other anogenital cancer, and oropharyngeal cancer; low-risk HPV types can cause genital warts. Cervical cancer is highly preventable through HPV vaccination and screening; however, a lack of awareness and knowledge of HPV and these preventive strategies represents an important barrier to reducing the burden of the disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2196/games.8540DOI Listing
April 2019
2 Reads

Cancer survival trends in Kuwait, 2000-2013: A population-based study.

Gulf J Oncolog 2019 Jan;1(29):39-52

Cancer Survival Group, London School of Hygiene and Tropical Medicine, London, UK.

Objective: To examine population-based cancer survival trends in Kuwait; to facilitate public assessment of cancer control.

Methods: Data were obtained from the Kuwait Cancer Registry for Kuwaiti adults (15-99 years) and children (0-14 years) diagnosed with one of 18 common cancers during 2000-2013 and followed up to 31 December 2014. Net survival was estimated at 1, 3, and 5 years by sex. Read More

View Article

Download full-text PDF

Source
January 2019
2 Reads

Radiobiological dose calculation parameters for cervix cancer brachytherapy: A systematic review.

Brachytherapy 2019 Apr 4. Epub 2019 Apr 4.

Division of Medical Physics, Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

The GEC-ESTRO recommendation in cervical cancer treatment planning, including external beam radiotherapy and brachytherapy boosts, is to use radiobiological dose calculations. Such calculations utilize the linear-quadratic model to estimate the effect of multiple cellular response factors and dose delivery parameters. The radiobiological parameters utilized in these calculations are literature values estimated based on clinical and experimental results. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brachy.2019.02.007DOI Listing

Modelling human papillomavirus biology in oropharyngeal keratinocytes.

Philos Trans R Soc Lond B Biol Sci 2019 May;374(1773):20180289

Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham , Vincent Drive, Birmingham B15 2TT , UK.

Most human papillomavirus (HPV) positive head and neck cancers arise in the tonsil crypts; deep invaginations at the tonsil surface that are lined with reticulated epithelium infiltrated by immune cells. As in cervical HPV infections, HPV16 is the most prevalent high-risk type in the oropharyngeal cancers, and a genital-oral route of infection is most likely. However, the natural history of HPV-driven oropharyngeal pathogenesis is an enigma, although there is evidence that it is different to that of cervical disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1098/rstb.2018.0289DOI Listing
May 2019
5 Reads

Development of a Vaginal Immobilization Device: A Treatment-planning Study of Carbon-ion Radiotherapy and Intensity-modulated Radiation Therapy for Uterine Cervical Cancer.

Anticancer Res 2019 Apr;39(4):1915-1921

Gunma University Heavy Ion Medical Center, Maebashi, Japan.

Aim: We developed a vaginal immobilization device for external radiotherapy in gynaecological malignancies and evaluated its bowel dose-reduction effect during carbon-ion radiotherapy (CIRT) and intensity-modulated radiation therapy (IMRT) in patients with cervical cancer.

Patients And Methods: Computed tomographic images obtained with and without the device in seven patients with cervical cancer were assessed. Treatment plans for CIRT and IMRT were generated, and dose-volume parameters (V, V, V, and D) of the rectum, sigmoidal colon, and bladder were evaluated. Read More

View Article

Download full-text PDF

Source
http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
Publisher Site
http://dx.doi.org/10.21873/anticanres.13300DOI Listing
April 2019
2 Reads

Isolated Drain Site Metastasis After Open Resection in Ileal Adenocarcinoma-an Uncommon Site.

Indian J Surg Oncol 2019 Mar 12;10(1):37-39. Epub 2018 May 12.

Department of Surgical Oncology, JIPMER, Puducherry, Puducherry, India.

Although port site implants have been described after laparoscopic resection for gastrointestinal malignancies, drain site metastasis in solid intra-abdominal tumor after open resection is a rare phenomenon. Only few cases have been reported in literature describing drain site metastasis after open resection for carcinoma in the colon, stomach, cervix etc. Isolated drain site metastasis is even rare. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13193-018-0745-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414717PMC
March 2019
3 Reads

Working together to eliminate cervical cancer: a partnership across three countries "As mudanças no mundo são criadas por nós".

Int J Gynecol Cancer 2019 Apr 3. Epub 2019 Apr 3.

Department of Gynecologic Oncology & Reproductive Medicine, MD Anderson Cancer Center, Houston, Texas, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/ijgc-2019-000372DOI Listing
April 2019
3 Reads

Central Vietnam needs you!

Authors:
Joseph Ng

Int J Gynecol Cancer 2019 Apr 3. Epub 2019 Apr 3.

OBGyn, Division of Gyn Onc, National University of Singapore, Singapore 119077, Singapore

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/ijgc-2019-000365DOI Listing
April 2019
1 Read

Ultrasonographic assessment of an induration caused by extravasation of a nonvesicant anticancer drug: A case report.

Medicine (Baltimore) 2019 Apr;98(14):e15043

Global Nursing Research Center.

Rationale: Induration may occur after an anticancer drug extravasation in patients who recurrently receive chemotherapy because of reduced choice of an appropriate vein for inserting a peripheral intravenous catheter, resulting in catheter placement difficulty. Although induration affects treatment, its size, shape, or hardness remains unclear in the conventional observation method using palpation and inspection. Here, we report our observation results in using ultrasonography to assess the induration that occurred after an anticancer drug extravasation as a new assessment method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000015043DOI Listing
April 2019
1 Read

Prevalence of cervical disease at age 20 after immunisation with bivalent HPV vaccine at age 12-13 in Scotland: retrospective population study.

BMJ 2019 Apr 3;365:l1161. Epub 2019 Apr 3.

Institute of Applied Health Services, University of Aberdeen, Aberdeen, UK.

Objective: To quantify the effect on cervical disease at age 20 years of immunisation with bivalent human papillomavirus (HPV) vaccine at age 12-13 years.

Design: Retrospective population study, 1988-96.

Setting: National vaccination and cervical screening programmes in Scotland. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmj.l1161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446188PMC
April 2019
2 Reads

Cervical screening and risk of adenosquamous and rare histological types of invasive cervical carcinoma: population based nested case-control study.

BMJ 2019 Apr 3;365:l1207. Epub 2019 Apr 3.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden.

Objectives: To examine the association of cervical cytology screening with the risk of adenosquamous cell carcinoma (ASC) and rare histological types of invasive cervical carcinoma (RICC), using comprehensive registry data, and to assess tumour human papillomavirus status of ASC and RICC.

Design: Nationwide, population based, nested case-control study.

Setting: Sweden. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmj.l1207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446178PMC
April 2019
3 Reads

Combination of SB431542, CHIR99021 and PD0325901 has a synergic effect on abrogating valproic acid‑induced epithelial‑mesenchymal transition and stemness in HeLa, 5637 and SCC‑15 cells.

Oncol Rep 2019 Jun 1;41(6):3545-3554. Epub 2019 Apr 1.

Ultrasound Department, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China.

Epithelial‑mesenchymal transition (EMT) plays an important role in cancer progression, metastasis and drug resistance, and recent studies have revealed that neoplastic epithelial cells regain the stem cell state through EMT. Single‑agent targeted cancer therapy frequently fails due to acquired drug resistance. Therefore, multi‑agent targeted therapy exhibits advantages in fighting cancer cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/or.2019.7088DOI Listing
June 2019
5 Reads

Cervical cancer screening decentralized policy adaptation: an African rural-context-specific systematic literature review.

Glob Health Action 2019 ;12(1):1587894

s Department of Family Medicine, Center for Global Health, Institute for Health Research and Policy, Cancer Center , University of Illinois at Chicago (UIC) , Chicago , IL , USA.

Background: Worldwide, nearly 570,000 women are diagnosed with cervical cancer each year, with 85% of new cases in low- and middle-income countries. The African continent is home to 35 of 40 countries with the highest cervical cancer mortality rates. In 2014, a partnership involving a rural region of Senegal, West Africa, was facing cervical cancer screening service sustainability barriers and began adapting regional-level policy to address implementation challenges. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/16549716.2019.1587894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450494PMC
January 2019

When Pap Testing Fails to Prevent Cervix Cancer: A Qualitative Study of the Experience of Screened Women Under 50 with Advanced Cervix Cancer in Canada.

Cureus 2019 Jan 24;11(1):e3950. Epub 2019 Jan 24.

Radiation Oncology, London Regional Cancer Program, University of Western Ontario, London, CAN.

Introduction: While Papanicolaou (Pap) smears have resulted in a significant decline in cervical cancer incidence and mortality, our clinical experience indicates some women still present with locally advanced cervical cancer (LACC) despite having received Pap smear screening. Recent guidelines have decreased the recommended frequency of Pap smears to every three years. Our study sought to investigate the experiences of young women compliant with cervical screening who presented with LACC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.3950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433450PMC
January 2019

Carcinosarcoma of the uterine cervix: a rare pathological finding originating from mesonephric remnants.

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

Gynecology Oncology, Instituto Português de Oncologia do Porto Francisco Gentil, Porto, Portugal.

Carcinosarcoma of the uterine cervix is a very rare tumour that has been described in less than 70 cases in the literature. It is less common compared with carcinosarcoma of the uterine corpus and it can have two origins: the Müllerian ducts and the mesonephric duct remnants. The association of mesonephric carcinoma with a sarcomatous component was reported in only 11 cases, including the following. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-227050DOI Listing
March 2019
3 Reads

A 3-step intervention to improve adherence to cervical cancer screening: The SCAN randomized controlled trial.

Prev Med 2019 Mar 30;123:250-261. Epub 2019 Mar 30.

EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal; Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina da Universidade do Porto, Porto, Portugal. Electronic address:

The aim of this study was to test the effectiveness of a stepwise intervention with an increasing level of complexity and cost to increase adherence to organized cervical cancer screening. This was a randomized (1: 1) controlled trial, conducted among 13 Portuguese primary health care units. Participants (n = 1220) were women aged 25-49 years, eligible for cervical cancer screening, with a mobile phone number available. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ypmed.2019.03.025DOI Listing
March 2019
4 Reads

Importance of training in external beam treatment planning for locally advanced cervix cancer: Report from the EMBRACE II dummy run.

Radiother Oncol 2019 Apr 28;133:149-155. Epub 2019 Jan 28.

Department of Oncology, Aarhus University Hospital, Denmark.

Background And Purpose: The EMBRACE II study combines state-of-the-art Image-Guided Adaptive Brachytherapy in cervix cancer with an advanced protocol for external beam radiotherapy (EBRT) which specifies target volume selection, contouring and treatment planning. In EMBRACE II, well-defined EBRT is an integral part of the overall treatment strategy with the primary aim of improving nodal control and reducing morbidity. The EMBRACE II EBRT planning concept is based on improved conformality through relaxed coverage criteria for all target volumes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.radonc.2019.01.012DOI Listing
April 2019
1 Read
4.363 Impact Factor