65,594 results match your criteria Cervix Cancer


Single layer colloid centrifugation technique improves motility, viability and chromatin integrity of ram spermatozoa after thawing.

Cryobiology 2018 Dec 3. Epub 2018 Dec 3.

Clinic for Reproduction and Large Animals, University of Ljubljana, Vet Faculty, Ljubljana, Slovenia.

The cell membrane of ram spermatozoa is more sensitive to the freezing process than in other species due to its composition. As a result, the quality and viability of frozen thawed ram spermatozoa are often poor, which together with the specific structure of the ewe's cervix are the main reasons for lower fertility in ewes after intracervical insemination. In the present study we investigated the effects of semen centrifugation through a single layer of a species-specific colloid (Androcoll-O) on post-thaw quality of ram spermatozoa. Read More

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December 2018

Rare lesion in the uterine cervix with irregular vaginal bleeding.

Am J Obstet Gynecol 2018 Dec 3. Epub 2018 Dec 3.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

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December 2018
1 Read

Identification of uterine telocytes and their architecture in leiomyoma.

Folia Med Cracov 2018 ;58(3):89-102

Department of Pathophysiology, Jagiellonian University Medical College, Kraków, Poland.

Introduction: Uterine leiomyoma is the most widespread benign tumor affecting women of childbearing age. ere are still gaps in the understanding of its pathogenesiss. Telocytes are unique cells described in greater than 50 different locations inside the human body. Read More

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January 2018
1 Read

In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra.

J Biomed Opt 2018 Dec;23(12):1-6

California Institute of Technology, Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Depa, United States.

Premature cervical remodeling is a critical precursor of spontaneous preterm birth, and the remodeling process is characterized by an increase in tissue hydration. Nevertheless, current clinical measurements of cervical remodeling are subjective and detect only late events, such as cervical effacement and dilation. Here, we present a photoacoustic endoscope that can quantify tissue hydration by measuring near-infrared cervical spectra. Read More

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December 2018
8 Reads
2.859 Impact Factor

Distinct Changes in the Expression TAZ are Associated with Normal Cervix and Human Cervical Cancer.

J Cancer 2018 20;9(22):4263-4270. Epub 2018 Oct 20.

Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P.R. China.

The transcriptional coactivator with the PDZ-binding motif (TAZ) has been associated with different types of cancer. In this study, we examined the TAZ protein expression and cellular localization in 194 cases of human cervical squamous cell carcinoma (SCC). We observed that a normal cervix is characterized by higher expression levels of both nuclear and cytosolic TAZ compared to cervical SCC. Read More

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October 2018

Using the Probability of Cesarean from a Validated Cesarean Prediction Calculator to Predict Labor Length and Morbidity.

Am J Perinatol 2018 Dec 3. Epub 2018 Dec 3.

Maternal and Child Health Research Center, Department of Obstetrics & Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

Objective:  To determine if increasing predicted risk of cesarean was associated with longer labor length and increased morbidity among women undergoing induction with an unfavorable cervix.

Study Design:  Using a publically available database, we evaluated whether a previously validated prediction model for cesarean delivery after induction was associated with labor length, maternal morbidity (third-/fourth-degree lacerations, endometritis, blood transfusion, wound infection, venous thromboembolism, hysterectomy, intensive care unit admission, and death), and neonatal morbidity (blood transfusion, encephalopathy, intraventricular hemorrhage, severe respiratory distress syndrome, necrotizing enterocolitis, and sepsis). Full-term (≥37 weeks) singleton gestations with intact membranes and an unfavorable cervix (Bishop score ≤6 and dilation ≤2 cm) undergoing induction of labor were included. Read More

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December 2018

Associations of temporal changes in cervical length and lower uterine segment length with spontaneous preterm delivery risk: a prospective study of 727 Japanese women.

J Med Ultrason (2001) 2018 Dec 1. Epub 2018 Dec 1.

Maternal and Child Health Center Aiiku Hospital, 1-16-10 Shibaura, Minato-ku, Tokyo, 105-0023, Japan.

Purpose: A prospective assessment of the risk of spontaneous preterm delivery (sPTD) by evaluating temporal changes in cervical measurements.

Methods: We analyzed clinical variables, focusing on cervical length (CL) and lower uterine segment (LUS) length (LUSL) as measured by transvaginal ultrasonography in 727 pregnant Japanese women.

Results: In women undergoing term deliveries, CL increased from gestational week (GW) 8-25. Read More

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December 2018
4 Reads

Dose to pelvic lymph nodes in image based high dose rate brachytherapy of carcinoma cervix.

Rep Pract Oncol Radiother 2019 Jan-Feb;24(1):80-85. Epub 2018 Nov 22.

Department of Radiation Oncology, Government Royapettah Hospital, India.

Aim: The aim of this study is to analyse the dosimetry to the pelvic lymph nodes and its correlation to point B using CT based high dose rate brachytherapy of carcinoma cervix.

Background: Conventionally, dose to pelvic lymph nodes from intracavitary brachytherapy was reported by point B and by the reference points of the lymphatic trapezoid.

Materials And Methods: 30 consecutive CT based high dose rate applications were reviewed between February and March 2016. Read More

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November 2018

Identification of Candidate Genes for Mayer-Rokitansky-Küster-Hauser Syndrome Using Genomic Approaches.

Sex Dev 2018 Dec 1. Epub 2018 Dec 1.

Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a disorder of sex development which affects 1 in 4,500 females and is characterized by agenesis of müllerian structures, including the uterus, cervix, and upper vagina. It can occur in isolation (type 1) or in conjunction with various anomalies (type 2), with a subset of these comprising müllerian, renal, and cervicothoracic abnormalities (MURCS) association. The genetic causes of MRKH have been investigated previously yielding limited results, with massive parallel sequencing becoming increasingly utilized. Read More

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December 2018

A high throughput bead-based affinity assay enables analysis of genital protein signatures in women at risk of HIV infection.

Mol Cell Proteomics 2018 Nov 30. Epub 2018 Nov 30.

Karolinska Institutet, Sweden.

Women at high risk of HIV infection, including sex workers and those with active genital inflammation, have molecular signatures of immune activation and epithelial barrier remodeling in samples of their genital mucosa. These alterations in the local immunological milieu are likely to impact HIV susceptibility. We here analyze host genital protein signatures in HIV uninfected women, with high frequency of condom use, living in HIV-serodiscordant relationships. Read More

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November 2018
2 Reads

Making the invisible visible: improving detectability of MRI-invisible residual cervical cancer after conisation by DCE-MRI.

Clin Radiol 2018 Nov 29. Epub 2018 Nov 29.

Department of Radiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address:

Aim: To determine whether dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) quantitative parameters increase the detectability of MRI-invisible residual cervical cancer after conisation.

Materials And Methods: This retrospective study included 59 patients with MRI-invisible cervical cancer, but positive conisation pathology. Thirty-five patients were confirmed to have residual cervical cancer, and 24 patients showed non-residual cervical cancer. Read More

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November 2018

Invasion of human deep nodular endometriotic lesions is associated with collective cell migration and nerve development.

Fertil Steril 2018 Dec;110(7):1318-1327

Institut du Sein et de Chirurgie Gynécologique d'Avignon, Polyclinique Urbain V (ELSAN Group), Avignon, France.

Objective: To study the mechanisms of invasion and innervation of deep endometriosis in women.

Design: Morphologic and immunohistochemical analysis of human endometriotic lesions.

Setting: Academic research unit. Read More

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December 2018

Ovarian reserve in adolescent girls born prematurely.

Horm Mol Biol Clin Investig 2018 Dec 5. Epub 2018 Dec 5.

Regional Children's Clinical Hospital, Kemerovo, Russia.

Background The objective was to estimate ovarian reserve in adolescent girls born prematurely. Materials and methods Two hundred adolescent girls aged 15-16 years who were born prematurely and full term were studied with laboratory, ultrasound and statistical methods. Results Statistically significant differences of the main parameters that characterize ovarian reserve in adolescent girls born prematurely compared to those born full term were specified. Read More

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December 2018
1 Read

Primary Angiosarcoma of the Cervix: Case Report of a Rare Lesion.

Int J Gynecol Pathol 2018 Dec 3. Epub 2018 Dec 3.

Department of Pathology, Royal Gwent Hospital, Newport (V.I.S., I.W.T.) Department of Pathology, University Hospital of Wales, Cardiff (G.L.R.) Department of Musculoskeletal Pathology, Royal Orthopaedic Hospital, Birmingham (V.P.S.) Department of Pathology, Belfast Health and Social Care Trust, Belfast (W.G.M.), UK.

Angiosarcomas of the female genital tract are rare and primary angiosarcoma of the cervix is extremely rare with only one prior case report. We report a case of a primary cervical angiosarcoma in a 43-yr-old woman who presented with heavy vaginal bleeding. Cervical biopsy and subsequent radical hysterectomy showed a malignant vascular tumor which was composed of spindled and epithelioid cells and formed abortive vascular channels. Read More

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December 2018
3 Reads

Wilms Tumor of the Ovary: Review of the Literature and Report of 2 Cases.

Int J Gynecol Pathol 2018 Dec 3. Epub 2018 Dec 3.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Primary extrarenal Wilms tumor of the gynecologic tract is extremely rare with scattered case reports occurring in the ovary, uterine corpus and cervix. Only 9 cases of primary ovarian Wilms tumor have been reported to date. Here, we provide an extensive literature review and describe 2 patients with ovarian Wilms tumor: a 36-yr-old female (patient 1) and a 16-yr-old female (patient 2), both presenting with abdominal pain and suspected ovarian torsion. Read More

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December 2018
1 Read

Cancer site differences in the health-related quality of life of Korean cancer survivors: Results from a Population-based Survey.

Public Health Nurs 2018 Dec 4. Epub 2018 Dec 4.

College of Nursing Science, Kyung Hee University, Seoul, South Korea.

Objectives: We investigated cancer site differences in the health-related quality of life (HRQOL) of cancer survivors.

Design And Sample: A secondary data analysis was conducted using the sixth Korea National Health and Nutrition Examination Survey (2013-2015). Participants were 15,461 adults (664 cancer survivors) with available EuroQol-5 Dimensions (EQ5D) information. Read More

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December 2018

Osseous Metaplasia of the Cervix: A Rare Transformation Can Mimic a Tumor-Literature Review.

Case Rep Pathol 2018 31;2018:1392975. Epub 2018 Oct 31.

Department of Pathology, Farwaniya Hospital, Kuwait.

Background: The transformation of nonosseous soft tissue into bone is known as osseous metaplasia (OM). This condition most commonly affects the musculoskeletal and central nervous systems and it is a well-known phenomenon in different soft tissue organs. Rarely, OM can affect the uterus, which can extend into the cervix. Read More

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October 2018

Efficacy of Intrauterine Lidocaine Instillation in Reducing Pain during Endometrial Biopsy by Novak.

Pain Res Treat 2018 1;2018:9368298. Epub 2018 Nov 1.

Department of Obstetrics and Gynecology, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.

Abnormal uterine bleeding in women aged 35 years or over is an important clinical sign of many gynecological conditions. The diagnoses of these conditions require the pathological report of the endometrial tissue. Outpatient-based endometrial biopsy is an excellent option compared to standard fractional uterine curettage or hysteroscopy with endometrial biopsy in providing a definite diagnosis for abnormal uterine bleeding as it is less painful and does not require high potency anesthesia. Read More

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November 2018
1 Read

Surgery on cervical folds for transcervical intrauterine artificial insemination with frozen-thawed semen enhances pregnancy rates in the sheep.

Theriogenology 2018 Nov 22;126:28-35. Epub 2018 Nov 22.

Section of Obstetrics and Gynecology, Department of Veterinary Medicine, University of Sassari, Sassari, Italy.

In sheep industry, genetic progress rate achieved by artificial insemination (AI) is limited by the convoluted anatomy of the cervix, which does not allow the passage of an insemination catheter for uterine semen deposition. The aim of this study was to test, in 98 pregnant at term Sarda ewes, the effects of: Experiment 1) total or partial ablation of cervical folds and Experiment 2) 4 or 2 incisions of cervical folds, on the passage of an insemination catheter, deposition of frozen-thawed semen and pregnancy rates. Surgical procedures were performed within 24 h from parturition providing deep sedation and epidural anaesthesia. Read More

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November 2018

Live-attenuated varicella zoster virus vaccine does not induce HIV target cell activation.

J Clin Invest 2018 Dec 4. Epub 2018 Dec 4.

Background: Varicella-zoster virus (VZV) is under consideration as a promising recombinant viral vector to deliver foreign antigens including HIV. However, new vectors have come under increased scrutiny since vaccination with Ad5-vectored HIV vaccine trials demonstrated increased HIV risk in individuals with pre-immunity to the vector which was thought to be associated with mucosal immune activation (IA). Therefore, defining the impact of VZV vaccination on IA is particularly important with the prospect of developing an HIV/VZV chimeric vaccine. Read More

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December 2018

[Clinical features and prognosis of cervical adenocarcinoma and adenosquamous carcinoma: an analysis of 237 cases].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2018 Feb;47(4):357-361

Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan 250012, China.

Objective: To analyze the clinical features and prognosis of cervical adenocarcinoma (AC) and adenosquamous carcinoma of cervix (ASC).

Methods: The clinical data of 237 patients, including 201 cases of AC and 36 cases of ASC (FIGO stage ⅠB1-ⅡA), who underwent surgery in Qilu Hospital between September 2007 and September 2016 were reviewed. Clinical features of two groups were compared, and Kaplan-Meier survival analysis was performed to evaluate the prognosis. Read More

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February 2018
3 Reads

[Value of combined detection of claudin 4 and high-risk human papilloma virus in high-grade squamous intraepithelial lesion and cervix squamous cell carcinoma].

Authors:
Chenhong Di Fan Jin

Zhejiang Da Xue Xue Bao Yi Xue Ban 2018 Feb;47(4):344-350

Department of Reproductive Genetics, Women's Hospital, Zhejiang University School of Medicine, Key Laboratory of Reproductive Genetics, Ministry of Education, Hangzhou 310006, China.

Objective: To investigate the expression of claudin 4 (CLDN4) in cervical tissues from patients with different cervical lesions, and to explore the value of combined detection of CLDN4 and high risk human papilloma virus (HR-HPV).

Methods: The cervical tissue specimens of low-grade squamous intraepithelial lesion (LSIL, =30), high-grade squamous intraepithelial lesion (HSIL, =30), squamous cell carcinoma (SCC, =30) as well as chronic cervicitis (control, =30) were collected from the Sir Run Run Shaw Hospital of Zhejiang University during June 2015 and December 2016. The expression of CLDN4 protein in tissue specimens was detected by immunohistochemistry, HR-HPV was detected by real-time quantitative PCR, and the cervical exfoliated cells were examined by thinprep cytologic test (TCT). Read More

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February 2018

[Key anatomies of DeLancey's three levels of vaginal support theory: an observation in laparoscopic surgery].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2018 Feb;47(4):329-337

Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Department of Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.

Objective: To observe and verify the key anatomies of DeLancey's three levels of vaginal support theory through laparoscopic surgery by space dissection technique.

Methods: The features and stress performance of related anatomies were observed and analyzed in laparoscopic type C hysterectomy and pelvic lymphadenectomy for cervical cancer by natural space exposures.

Results: The main ligament-like structure at level Ⅰ was the uterosacral ligament, which acted as the main apical fixation in the sacral direction, while the cardinal ligament was mainly composed of vascular system, lymph-vessels and loose connective tissue around them, lacking the tough connective tissue structures, which was connected to the internal iliac vascular system. Read More

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February 2018

Atypical Hemolytic Uremic Syndrome Presenting as Pre-eclampsia in a 24-year-old Woman with Chronic Kidney Disease: Pathogenesis and Genetics.

Cureus 2018 Sep 25;10(9):e3358. Epub 2018 Sep 25.

Internal Medicine, Brookdale University Hospital, New York, USA.

Atypical hemolytic uremic syndrome (aHUS) is a kidney disorder that is frequently unrecognized during its progression, and misdiagnosed with more common etiologies of microangiopathic hemolytic anemia (MAHA): hemolytic uremic syndrome, disseminated intravascular coagulation, and thrombotic thrombocytopenic purpura (TTP). During pregnancy, the diagnosis of aHUS is furthermore challenging. The clinical presentation of aHUS may mimic pre-eclampsia as it occurred to the patient described in the case report. Read More

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September 2018
1 Read

Influence of cervical cerclage interventions upon the incidence of neonatal death: a retrospective study comparing prophylactic versus rescue cerclages.

Facts Views Vis Obgyn 2018 Mar;10(1):29-36

Department of Obstetrics and Prenatal Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.

Objective: The purpose of this study was to compare the efficacy of prophylactic and rescue cervical cerclages for pregnant patients with an incompetent cervix, and to assess the neonatal outcomes of both clinical conditions.

Methods: This was a retrospective observational study of all women who had an elective or rescue cerclage between January 2008 and December 2016 in our institution. Prophylactic cerclage was defined as a cerclage before 16 weeks of gestation, while rescue cerclages were performed between 16 and 23 weeks of gestation. Read More

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Patient-reported sexual adjustment after definitive chemoradiation and MR-guided brachytherapy for cervical cancer.

Brachytherapy 2018 Nov 30. Epub 2018 Nov 30.

Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; Radiation Medicine Program, University Health Network, Toronto, Ontario, Canada. Electronic address:

Purpose: The treatment of locally advanced cervical cancer with definitive chemoradiation (CRT) is associated with vaginal toxicity and altered sexual satisfaction. This prospective study assessed patient-reported sexual adjustment, vaginal dosimetry, and physician-reported vaginal toxicity in patients with cervical cancer treated with CRT and MR-guided brachytherapy (BT).

Materials And Methods: Between 2008 and 2010, International Federation of Gynecologists and Obstetricians stage IB-IVA patients with cervical cancer receiving definitive CRT were enrolled in a feasibility study assessing MR-guided BT. Read More

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November 2018

Intralesional and subcutaneous application of Viscum album L. (European mistletoe) extract in cervical carcinoma in situ: A CARE compliant case report.

Medicine (Baltimore) 2018 Nov;97(48):e13420

Institute for Applied Epistemology and Medical Methodology at the University of Witten/Herdecke.

Rationale: Carcinoma in situ (CIS) of the uterine cervix is a premalignant condition of squamous epithelium. The standard treatments are excision and ablation procedures; for women with positive margins, hysterectomy is recommended.

Patient Concerns: A 47-year-old Peruvian woman with recurrent candidal vaginitis had been diagnosed with colpocervicitis and squamous metaplasia 8 years ago, which were not treated. Read More

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November 2018

Rehydration of Air-Dried Smears with Normal Saline: An Alternative for Conventional Wet Fixation Method in Cervical Cytological Study.

J Cytol 2018 Oct-Dec;35(4):199-203

Department of Pathology, B.L.D.E University's Shri. B. M. Patil Medical College Hospital and Research Centre, Bijapur, Karnataka, India.

Context: Papanicolaou (Pap) smear is an effective exfoliative cytological investigation done for early recognition of cervical cancer. It also plays role in diagnosis of inflammatory lesions of cervix.

Aims: The aim of this study is (1) to compare the cytomorphological features in conventional Pap smear (C-PAPS) and rehydrated air-dried Pap smear (RADPS) and (2) to evaluate the efficacy of RADPS in cytodiagnosis of cervical lesion by comparing with cytomorphological features of conventional wet-fixed Pap smear. Read More

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December 2018

Carcinoma of the uterine cervix in Czech Republic and possibilities of its prevence.

Cesk Patol 2018 ;63(4):164-168

Carcinoma of the uterine cervix belongs to significant malignancy in the Czech Republic. The goal of organized national cervical cancer screening program is to decrease incidence and mortality of this disease. Discovery of casual relationship between human papillomavirus (HPV) and cervical cancer together with modern examinations methods pushed forward possibilities of primary and secondary prevention worldwide. Read More

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January 2018

Case of Laceration of the Cervix Uteri, Consequent on Passive Labour.

Authors:
Thomas Aspray

Lond Med Phys J 1822 May;47(279):372-374

Licentiate of the Honourable Company of Apothecaries.

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Optimal technique of radiotherapy for carcinoma cervix in developing countries: Dosimetric and logistic comparison.

J Cancer Res Ther 2018 Oct-Dec;14(6):1207-1213

Department of Radiation Oncology, MS Ramaiah Medical College Hospital, Bengaluru, Karnataka, India.

Purpose: Carcinoma cervix is the most common malignancy affecting women in developing countries. Radical radiotherapy is the mainstay of treatment in more than 90% of patients. The present study is a dosimetric and logistic comparison of various techniques of radiotherapy, namely two-dimensional conventional radiotherapy (2DCRT), three-dimensional conformal radiotherapy (3DCRT), and intensity-modulated radiotherapy (IMRT). Read More

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November 2018
2 Reads

The clinical significance of FAM19A4 methylation in high-risk HPV-positive cervical samples for the detection of cervical (pre)cancer in Chinese women.

BMC Cancer 2018 Nov 29;18(1):1182. Epub 2018 Nov 29.

Department of Gynecology, Guangdong Women and Children Hospital, 521 Xing Nan Road, Guangzhou, 511400, Guangdong Province, China.

Background: To explore the diagnostic value of FAM19A4 methylation in high-risk human papilloma virus (hrHPV)-positive cervical samples from Chinese women for estimating cervical cancer or its precancerous lesions.

Methods: Cervical samples from 215 women infected with high-risk HPV were collected by smear testing. We purposely chose 61 patients with cervical cancer, 57 with high-grade squamous intraepithelial lesions (HSIL), 31 with low-grade squamous intraepithelial lesions (LSIL), and 66 without cervical intraepithelial neoplasia (CIN) after histological confirmation. Read More

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November 2018

Blunt dissection technique with finger and vessel skeletonization in the posterior vesical wall for abnormally invasive placenta previa.

J Matern Fetal Neonatal Med 2018 Nov 28:1-71. Epub 2018 Nov 28.

a Department of Obstetrics and Gynecology , Gaziantep University , School of Medicine , Gaziantep , Turkey.

Purpose: This study described a new technique to minimize the bleeding resulted from aberrant engorged vessels and unintended bladder injury in cases with abnormally invaded placenta adjacent to posterior bladder wall at cesarean hysterectomy.

Methods: After filling the bladder with 300 ml saline aberrant engorged vessels were identified and skeletonized between lower uterine segment and bladder with blunt dissection by index finger down to the distal end point of cervix.

Results: This technique has beneficial effect on preventing bladder injury and reduces bleeding resulting from the aberrant vessels and the communicating vessels that were based around the vesicouterine fold and the cervico-vesical interface (in the lower part of the cervix); respectively. Read More

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November 2018

Evaluation of Anal Cytology in Women with History of Abnormal Pap Smear, Cervical Intraepithelial Neoplasia, Cervical Cancer and High Risk HPV for Anogenital Dysplasia

Asian Pac J Cancer Prev 2018 Nov 29;19(11):3071-3075. Epub 2018 Nov 29.

Preventative Gynecology Research Center, ShahidBeheshti University of Medical Sciences, Tehran, Iran. Email:

Background: Anal cancer is uncommon. Although uncommon, the incidence of anal cancer has increased among the general population of the United States and other countries over the past 30 years. We evaluated anal cytology in women with the history of abnormal pap smear, cervical intraepithelial neoplasia, cervical cancer and high risk HPV for anogenital dysplasia. Read More

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November 2018

Hysterotomy level at cesarean section and occurrence of large scar defects: a randomized single-blind trial.

Ultrasound Obstet Gynecol 2018 Nov 28. Epub 2018 Nov 28.

Department of Obstetrics and Gynecology, St. Olavs hospital, Trondheim University Hospital, Trondheim, Norway.

Objective: To study the effect of cesarean hysterotomy level on the occurrence of large uterine scar defects 6-9 months after delivery.

Methods: This was a two-center, randomized, single-blind trial of a surgical procedure with masked assessment of the principal outcome under study. Women in active labor (cervix dilatation ≥5 cm) were randomized into a high incision (HIGH) or a low incision (LOW) group. Read More

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November 2018

Rare Pelvic Malignant Tumors in Adults: Treatment Features and Clinical Outcome in Nonmetastatic Disease (Single Institution Experience).

Cancer Biother Radiopharm 2018 Nov 28. Epub 2018 Nov 28.

1 Department of Oncology-Radiotherapy, Institute of Oncology "Prof. Dr. Alexandru Trestioreanu," Bucharest, Romania .

Background: Nearly 200 cancers repertories are rare, and more than 20% are pelvic neoplasia. Diagnosis and treatment are challenging, even in reference centers, and survival is influenced by the aggressiveness of certain histologies and absence of a standard of care.

Patients And Methods: The authors report the results of a retrospective analysis of patients that attended the Institute of Oncology, Bucharest, between 2004 and 2015, for nonmetastatic pelvic malignant tumor treatment and follow-up. Read More

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November 2018
1 Read

Glycoprotein nonmetastatic melanoma protein B accelerates tumorigenesis of cervical cancer in vitro by regulating the Wnt/β-catenin pathway.

Braz J Med Biol Res 2018 Nov 23;52(1):e7567. Epub 2018 Nov 23.

Department of Obstetrics and Gynecology, Huashan Hospital North, Fudan University, Shanghai, China.

Cervical cancer is one of the most common cancers among women around the world. However, the underlying mechanism involved in cervical cancer progression is incompletely known. In the present study, we determined the role of glycoprotein nonmetastatic melanoma protein B (GPNMB) in tumorigenesis of cervical cancer. Read More

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November 2018

Large Cell Neuroendocrine Carcinoma of the Cervix with Sequential Metastasis to Different Sites: A Case Report.

Case Rep Oncol 2018 Sep-Dec;11(3):665-670. Epub 2018 Oct 23.

Department of Obstetrics and Gynecology, Inje University Haeundae Paik Hospital, Busan, Republic of Korea.

Neuroendocrine carcinoma of the cervix is rare, and prognosis is very poor. Because of its rarity, effective treatment of neuroendocrine carcinoma of the cervix has not been established. It has distinct patterns of metastasis, but can be successfully treated with radical surgery and platinum-based chemotherapy. Read More

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October 2018

Vaginal progesterone, oral progesterone, 17-OHPC, cerclage and pessary for preventing preterm birth in at risk singleton pregnancies: an updated systematic review and network meta-analysis.

BJOG 2018 Nov 27. Epub 2018 Nov 27.

Department of Obstetrics and Gynecology, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada.

Background: Recent progesterone trials call for an update of previous syntheses of interventions to prevent preterm birth.

Objectives: To compare the relative effects of different types and routes of administration of progesterone, cerclage and pessary at preventing preterm birth in at-risk women overall and in specific populations.

Search Strategy: We searched Medline, EMBASE, CINAHL, Cochrane CENTRAL, and Web of Science up to January 1 , 2018. Read More

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November 2018
3.448 Impact Factor

Cancer Burden in Adolescents and Young Adults: A Review of Epidemiological Evidence.

Cancer J 2018 Nov/Dec;24(6):256-266

Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France.

Cancer burden in adolescents and young adults (AYAs) is expressed through a large proportion of the quality of life lost on individual level and also causes losses to the society in terms of a decreased productivity and social structure. A specific cancer spectrum and distinctive needs of AYA patients require targeted studies and cancer control measures. Incidence is intermediate between that for children and for older adults, and two-thirds of the AYA cancers affect women. Read More

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November 2018

Comparison of impact of target delineation of computed tomography- and magnetic resonance imaging-guided brachytherapy on dose distribution in cervical cancer.

J Contemp Brachytherapy 2018 Oct 15;10(5):418-424. Epub 2018 Oct 15.

Division of Radiation Oncology, Department of Radiology.

Purpose: The dose distributions obtained from three imaging approaches for target delineation in cervical cancer using high-dose-rate (HDR) brachytherapy were investigated.

Material And Methods: Ten cervical cancer patients receiving four fractions of HDR brachytherapy were enrolled. Based on different imaging approaches, three brachytherapy plans were developed for each patient: with the high-risk clinical target volume (HRCTV) delineated on magnetic resonance (MRI) images for every fraction (approach A; MRI-only); on MRI for the first fraction and computed tomography (CT) images for the subsequent fractions (approach B; MRI/CT); and on CT images for all fractions (approach C; CT-only). Read More

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October 2018
1 Read

Significance of elevated SCC-Ag level on tumor recurrence and patient survival in patients with squamous-cell carcinoma of uterine cervix following definitive chemoradiotherapy: a multi-institutional analysis.

J Gynecol Oncol 2018 Apr 30. Epub 2018 Apr 30.

Department of Radiation Oncology, St. Vincent's Hospital, The Catholic University of Korea College of Medicine, Suwon, Korea.

Objective: There is no definitive guideline for the significance and cut-off value of squamous-cell carcinoma antigen (SCC-Ag) in cervical cancer. Thus, we analyzed the significance and optimal cut-off value of SCC-Ag for predicting tumor recurrence and patient survival in squamous-cell carcinoma of uterine cervix.

Methods: From January 2010 to October 2016, we enrolled 304 cervical cancer patients with squamous-cell carcinoma staging International Federation of Gynecology and Obstetrics (FIGO) Ib-IVa and treated with definitive chemoradiotherapy (CRT) followed by intra-cavitary radiotherapy (ICR). Read More

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April 2018
1 Read

Evaluation of Second Solid Cancers After Hematopoietic Stem Cell Transplantation in European Patients.

JAMA Oncol 2018 Nov 21. Epub 2018 Nov 21.

Center for Haematology, Imperial College, London, United Kingdom.

Importance: Incidence and risk factors of second solid cancers (SSCs) that occur after hematopoietic stem cell transplantation (HSCT) are well documented. However, clinical outcome data of patients who developed an SSC after HSCT are limited.

Objective: To assess the outcome of patients with an SSC occurring after HSCT from the time of SSC diagnosis. Read More

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November 2018
4 Reads

Tumor-infiltrating CD8+ and FOXP3+ lymphocytes before and after neoadjuvant chemotherapy in cervical cancer.

Diagn Pathol 2018 Nov 24;13(1):93. Epub 2018 Nov 24.

Department of Surgical Pathology, Women's Hospital, School of Medicine, Zhejiang University, Province, Zhejiang, 310006, China.

Background: Neoadjuvant chemotherapy (NACT) has been recently accepted as an effective alternative in patients with locally advanced cervical cancer. However, little is known about the effects of NACT on the immunological microenvironment in cervical cancers. In this study, we analyzed the alterations of tumor infiltrating lymphocytes (TILs) before and after NACT and analyzed their prognostic significance in advanced cervical cancer patients treated with platinum-based NACT. Read More

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November 2018
5 Reads

A divergence between underlying and final causes of death in selected conditions: an analysis of death registries in Peru.

PeerJ 2018 12;6:e5948. Epub 2018 Nov 12.

CRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.

Background: The underlying cause of death is used to study country and global mortality trends and profiles. The final cause of death could also inform the ultimately cause of death in individuals with underlying conditions. Whether there is a pattern between the underlying and final cause of death has not been explored using national death registries. Read More

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November 2018

Robot-assisted resection of ectopic kidney in children: An anatomical illustration.

J Pediatr Urol 2018 Oct 27. Epub 2018 Oct 27.

Department of Urology, Ghent University Hospital, Belgium. Electronic address:

Introduction: Failure of kidney migration during embryonic life results in an ectopic kidney, with an incidence varying from 1 in 500 to 1 in 1200. Pelvic kidney can be a rare cause of recurrent urinary tract infection (UTI), warranting nephrectomy in some cases.

Material And Methods: A 7-year-old girl with a history of recurrent UTIs and vaginal discharge was diagnosed with a dysplastic afunctional ectopic kidney located in the pelvis, with ureter draining into the cervix or vaginal wall. Read More

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October 2018

Quantitative Ultrasound Biomarkers Based on Backscattered Acoustic Power: Potential for Quantifying Remodeling of the Human Cervix during Pregnancy.

Ultrasound Med Biol 2018 Nov 22. Epub 2018 Nov 22.

Medical Physics Department, University of Wisconsin, Madison, Wisconsin, USA. Electronic address:

As pregnancy progresses, the cervix remodels from a rigid structure to one pliable enough to allow delivery of a fetus, a process that involves progressive disorganization of cervical microstructure. Quantitative ultrasound biomarkers that may detect this process include those derived from the backscattered echo signal, namely, acoustic attenuation and backscattered power loss. We recently reported that attenuation and backscattered power loss are affected by tissue anisotropy and heterogeneity in the ex vivo cervix. Read More

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November 2018

Müllerian aplasia with severe hematometra: A case report of diagnosis and management in a low resource setting.

J Pediatr Adolesc Gynecol 2018 Nov 21. Epub 2018 Nov 21.

Department of Obstetrics and Gynecology University of Iowa Carver College of Medicine 200 Hawkins Dr. Iowa City, IA 52241.

Background: Müllerian aplasia or Mayer-Rokitansky-Küster-Hauser syndrome is described as congenital absence of the proximal vagina with or without absence of the cervix and uterus, most often recognized following the onset of primary amenorrhea.

Case: An 18-year-old female presented to a free medical clinic in Arcahaie, Haiti with primary amenorrhea, abdominal distention and cyclic monthly abdominal pain. Physical exam was significant for uterus palpable superior to the umbilicus, absence of vagina, and rectal exam without palpable vagina or cervix. Read More

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November 2018
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MALDI Imaging for Proteomic Painting of Heterogeneous Tissue Structures.

Proteomics Clin Appl 2018 Nov 24:e1800045. Epub 2018 Nov 24.

Proteopath GmbH, Trier 54296, Germany.

Purpose: To present matrix-assisted laser desorption/ionization (MALDI) imaging as a powerful method to highlight various tissue compartments.

Experimental Design: Formalin-fixed paraffin-embedded (FFPE) tissue of a uterine cervix, a pancreas, a duodenum, a teratoma, and a breast cancer tissue microarray (TMA) are analyzed by MALDI imaging and by immunohistochemistry (IHC). Peptide images are visualized and analyzed using FlexImaging and SCiLS Lab software. Read More

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November 2018
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Pulmonary metastasis of mesonephric-like adenocarcinoma arising from the uterine body: a striking mimicry of follicular thyroid carcinoma.

Histopathology 2018 Nov 24. Epub 2018 Nov 24.

Department of Diagnostic Pathology, Anjo Kosei Hospital, 28 Higashi-hirokute, Anjo-cho, Anjo, Aichi, 446-8602, Japan.

Mesonephric adenocarcinoma (MNAC) is a rare neoplasm that presumably develops from the mesonephric remnants, occurring mostly in the uterine cervix and, to a lesser extent, the vagina, uterine body, ovary, and para-adnexal soft tissues. Histologically, MNAC exhibits a variety of architectural growth patterns, even within the same tumour, including tubular, glandular, papillary, solid, and retiform, and therefore may be confused with more common carcinomas of Müllerian origin. Moreover, the tubules with luminal eosinophilic secretions, a common characteristic of MNACs, may result in consideration of thyroidal carcinoma when tumours spread beyond the pelvis. Read More

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November 2018
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