92,617 results match your criteria Cervix Cancer

Conventional Laparoscopy versus Robotic-Assisted Aortic Lymph-Nodal Staging for Locally Advanced Cervical Cancer: A Systematic Review and Meta-Analysis.

J Clin Med 2022 Jun 10;11(12). Epub 2022 Jun 10.

Unit of Gynecologic Oncology, ARNAS "Civico-Di Cristina-Benfratelli", 90127 Palermo, Italy.

Aortic lymph node metastases are a relative common finding in locally advanced cervical cancer. Minimally invasive surgery is the preferred approach to perform para-aortic lymph nodal staging to reduce complications, hospital stay, and the time to primary treatment. This meta-analysis (CRD42022335095) aimed to compare the surgical outcomes of the two most advanced approaches for the aortic staging procedure: conventional laparoscopy (CL) versus robotic-assisted laparoscopy (RAL). Read More

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A Survey on Deep Learning for Precision Oncology.

Diagnostics (Basel) 2022 Jun 17;12(6). Epub 2022 Jun 17.

Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei 106335, Taiwan.

Precision oncology, which ensures optimized cancer treatment tailored to the unique biology of a patient's disease, has rapidly developed and is of great clinical importance. Deep learning has become the main method for precision oncology. This paper summarizes the recent deep-learning approaches relevant to precision oncology and reviews over 150 articles within the last six years. Read More

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Review of the Standard and Advanced Screening, Staging Systems and Treatment Modalities for Cervical Cancer.

Cancers (Basel) 2022 Jun 13;14(12). Epub 2022 Jun 13.

Department of Microbiology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, China.

Cancer arising from the uterine cervix is the fourth most common cause of cancer death among women worldwide. Almost 90% of cervical cancer mortality has occurred in low- and middle-income countries. One of the major aetiologies contributing to cervical cancer is the persistent infection by the cancer-causing types of the human papillomavirus. Read More

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Antioxidative, Antibacterial and Antiproliferative Properties of Honey Types from the Western Balkans.

Antioxidants (Basel) 2022 Jun 6;11(6). Epub 2022 Jun 6.

Institute of Food Technology in Novi Sad, University of Novi Sad, Bulevar cara Lazara 1, 21000 Novi Sad, Serbia.

This paper presents the physicochemical characteristics and antioxidative, antibacterial and antiproliferative effects of nineteen samples of different honey types (acacia, linden, heather, sunflower, phacelia, basil, anise, sage, chestnut, hawthorn, lavender and meadow) collected from different locations in the Western Balkans (Republic of Serbia, Kosovo, Bosnia and Herzegovina, and Northern Macedonia). Physicochemical parameters (moisture, pH, electrical conductivity, free acidity, and hydroxymethylfurfural [HMF]) were analysed. Based on the obtained results, all tested honey samples were in agreement with EU regulation. Read More

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Barriers to Accessing Contraception and Cervical and Breast Cancer Screening During the COVID-19 Pandemic.

J Obstet Gynaecol Can 2022 Jun 20. Epub 2022 Jun 20.

School of Population and Public Health, University of British Columbia, University of British Columbia, Vancouver, BC, Canada V6T 1Z4.

Objective: This study sought to examine how access to contraception and cervical and breast cancer screening British Columbia, Canada, has been affected by COVID-19 pandemic.

Methods: From August 2020 to March 2021, 3691 female residents of British Columbia (age 25-69 y) participated in this study. We used generalized estimating equations to analyze the proportion of females accessing contraception and the proportion having difficulty accessing contraception across the phases of pandemic control measures, and logistic regression to analyze cervical and breast cancer screening. Read More

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Shotgun Lipidomics for Differential Diagnosis of HPV-Associated Cervix Transformation.

Metabolites 2022 May 31;12(6). Epub 2022 May 31.

National Medical Research Center for Obstetrics Gynecology and Perinatology Named after Academician V.I., Kulakov of the Ministry of Healthcare of Russian Federation, 117997 Moscow, Russia.

A dramatic increase in cervical diseases associated with human papillomaviruses (HPV) in women of reproductive age has been observed over the past decades. An accurate differential diagnosis of the severity of cervical intraepithelial neoplasia and the choice of the optimal treatment requires the search for effective biomarkers with high diagnostic and prognostic value. The objective of this study was to introduce a method for rapid shotgun lipidomics to differentiate stages of HPV-associated cervix epithelium transformation. Read More

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Simplified Convolutional Neural Network Application for Cervix Type Classification via Colposcopic Images.

Bioengineering (Basel) 2022 May 30;9(6). Epub 2022 May 30.

Personalised Medicine Centre, 197341 St. Petersburg, Russia.

The inner parts of the human body are usually inspected endoscopically using special equipment. For instance, each part of the female reproductive system can be examined endoscopically (laparoscopy, hysteroscopy, and colposcopy). The primary purpose of colposcopy is the early detection of malignant lesions of the cervix. Read More

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Willingness to Self-Collect a Sample for HPV-Based Cervical Cancer Screening in a Well-Screened Cohort: HPV FOCAL Survey Results.

Curr Oncol 2022 May 26;29(6):3860-3869. Epub 2022 May 26.

Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

Self-collection may provide an opportunity for innovation within population-based human papillomavirus (HPV) cervical cancer screening programs by providing an alternative form of engagement for all individuals. The primary objective was to determine willingness to self-collect a vaginal sample for primary HPV screening and factors that impact willingness in individuals who participated in the Human Papillomavirus For Cervical Cancer (HPV FOCAL) screening trial, a large randomized controlled cervical screening trial. A cross-sectional online survey was distributed between 2017 and 2018 to 13,176 eligible participants exiting the FOCAL trial. Read More

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Cervix Type and Cervical Cancer Classification System Using Deep Learning Techniques.

Med Devices (Auckl) 2022 16;15:163-176. Epub 2022 Jun 16.

Biomedical Imaging Unit, School of Biomedical Engineering, Jimma Institute of Technology, Jimma University, Jimma, Ethiopia.

Purpose: Cervical cancer is the 4th most common cancer among women, worldwide. Incidence and mortality rates are consistently increasing, especially in developing countries, due to the shortage of screening facilities, limited skilled professionals, and lack of awareness. Cervical cancer is screened using visual inspection after application of acetic acid (VIA), papanicolaou (Pap) test, human papillomavirus (HPV) test and histopathology test. Read More

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HIV status, knowledge and prevention of cervical cancer amongst adolescent girls and women: a secondary data analysis.

Pan Afr Med J 2022 31;41:262. Epub 2022 Mar 31.

Columbia University, Harare, Zimbabwe.

Introduction: the objective of this manuscript was to describe the knowledge profiles and determinants of cervical cancer screening among HIV positive and negative adolescent girls and women in Zimbabwe.

Methods: we conducted secondary statistical data analysis to explore the determinants of cervical cancer screening among HIV positive and negative adolescent girls and women using Zimbabwe Demographic Health survey for 2015-16.

Results: a total of 9054 adolescent girls aged 15-19, and women aged 20-49 were included in the analysis and the majority (63%) of them resided in rural areas. Read More

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Not Your Typical Adenocarcinoma: A Case of Mesonephric Adenocarcinoma of the Cervix With Fibroblast Growth Factor Receptor 2 (FGFR2) Mutation.

Cureus 2022 May 18;14(5):e25098. Epub 2022 May 18.

Hematology and Oncology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, USA.

Cervical cancer is one of the leading causes of cancer mortality in women. However, there have been great advances in its prevention and treatment. Nevertheless, there are certain rare forms of this cancer that are under-recognized, underreported, and have a paucity of evidence in terms of treatment. Read More

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DeepCyto: a hybrid framework for cervical cancer classification by using deep feature fusion of cytology images.

Math Biosci Eng 2022 Apr;19(7):6415-6434

Department of Computer Engineering, Pimpri Chinchwad College of Engineering, Pune, Maharashtra, India.

Cervical cancer is the second most commonly seen cancer in women. It affects the cervix portion of the vagina. The most preferred diagnostic test required for screening cervical cancer is the pap smear test. Read More

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Low Tumor Infiltrating Mast Cell Density Reveals Prognostic Benefit in Cervical Carcinoma.

Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221106530

Department of Medical Laboratory Center, Tumor Hospital Affiliated to Xinjiang Medical University, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi, Xinjiang, China.

Research on the role of mast cells (MCs) in cervical tumor immunity is more limited. Therefore, our study aimed to evaluate the prognostic value of MCs and their correlation with the immune microenvironment of cervical carcinoma (CC). The Cancer Genome Atlas (TCGA) data was utilized to obtain the degree of immune infiltration of MCs in CC. Read More

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Blocking TIGIT/CD155 signalling reverses CD8 T cell exhaustion and enhances the antitumor activity in cervical cancer.

J Transl Med 2022 Jun 21;20(1):280. Epub 2022 Jun 21.

Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Address: No.107, west culture road, Jinan, 250012, Shandong, China.

Objective: TIGIT/CD155 has attracted widespread attention as a new immune checkpoint and a potential target for cancer immunotherapy. In our study, we evaluated the role of TIGIT/CD155 checkpoints in the progression of cervical cancer.

Methods: The expression of CD155 and TIGIT in cervical cancer tissues was detected using flow cytometry, immunohistochemistry (IHC) and gene expression profiling. Read More

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Patient choice may improve adherence to follow-up in cervical screening: a randomised-control trial.

N Z Med J 2022 Feb 25;135(1550):146-156. Epub 2022 Feb 25.

FRANZCOG, Gynaecologic Oncologist at Christchurch Women's Hospital.

Aims: We investigated whether patient choice of follow-up type improves health-related quality of life (HrQOL) and follow-up attendance in women who have undergone large loop excision of the transformation zone (LLETZ) for cervical intraepithelial neoplasia grade 2 to 3 (CIN 2-3).

Methods: A three-armed randomised controlled trial including women with newly diagnosed CIN 2-3 post-LLETZ treatment was performed. Consenting women were randomised (1:1:1) to either: (a) colposcopy review at the hospital, (b) follow-up with high-risk human papilloma virus (HrHPV) and smear test in the community or (c) a choice of the aforementioned follow-up options, six months post-treatment. Read More

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February 2022

Phase I study of adjuvant immunotherapy with autologous tumor-infiltrating lymphocytes in locally advanced cervical cancer.

J Clin Invest 2022 Jun 21. Epub 2022 Jun 21.

Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, China.

Background: Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) has achieved remarkable clinical efficacy in metastatic cancers such as melanoma and cervical cancer (CC). Here we explored the safety, feasibility and preliminary tumor response and performed translational investigations of adjuvant immunotherapy using infusion of autogenous (auto)-TILs following concurrent chemoradiotherapy (CCRT) in CC patients with locally advanced disease.

Methods: Twenty-seven CC patients with stage III to IV disease were recruited in this single-center, phase I study. Read More

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Modified method of cervical conization with hybrid use of a cold knife and an electric knife for high-grade squamous intraepithelial lesions.

J Int Med Res 2022 Jun;50(6):3000605221106414

Department of Gynecology, Affiliated Women and Children's Hospital of Ningbo University, Ningbo, Zhejiang, 315012, China.

Objective: To evaluate the feasibility and surgical outcome of the modified method of cervical conization with hybrid use of a cold knife and an electric knife.

Methods: A retrospective analysis of cervical conization for high-grade squamous intraepithelial lesions was performed between January 2020 and December 2020. Traditional cold knife conization and modified conization were used. Read More

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Connaissances, attitudes et pratiques des professionnels de santé sur le cancer du col de l’utérus au Cameroun.

Sante Publique 2021 ;32(5):489-496

Introduction: Cervical cancer is the cause of 311,000 deaths each year worldwide and 1,540 deaths in Cameroon. It is a public health problem, but only one in ten women is screened for cervical cancer screening in Cameroon. Little data is available on the KAPs of health professionals in the Mifi Health District, in the west Region of Cameroon. Read More

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Facteurs associés aux barrières d’accès au dépistage du cancer du col de l’utérus à Yaoundé.

Sante Publique 2021 ;33(4):579-589

Introduction: Several studies report that only 10% of Cameroonian women at risk have ever been screened for this disease.

Objective: This study aims to analyze the factors explaining the difficulties in accessing screening for cervical cancer in Yaoundé, Cameroon.

Methodology: This was an analytical cross-sectional study (participed/not participated), conducted from May 1 to August 10, 2020. Read More

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Women's sexual autonomy as a determinant of cervical cancer screening uptake in Addis Ababa, Ethiopia: a case-control study.

BMC Womens Health 2022 06 17;22(1):236. Epub 2022 Jun 17.

Department of Preventive Medicine, School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia.

Cervical cancer (CC) is the fourth most common cancer in women worldwide and the leading cause of cancer deaths in developing countries. CC can be prevented through available preventive interventions. However, most patients in developing countries, such as Ethiopia, present late with advanced stage disease due to low participation in CC screening and require treatment involving multiple modalities. Read More

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In-vitro antiproliferative efficacy of Abrus precatorius seed extracts on cervical carcinoma.

Sci Rep 2022 Jun 17;12(1):10226. Epub 2022 Jun 17.

Therapeutics and Molecular Diagnostic Lab, Center for Medical Biotechnology, Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India.

Abrus precatorius is a tropical medicinal plant with multiple medicinal benefits whose seeds have not yet been studied against cervical cancer. Herein, we have assessed the antioxidant and antiproliferative properties of seed extracts (ethyl acetate and 70% ethanol) prepared from Soxhlet and Maceration extraction methods against Hep2C and HeLa Cells. We observed that the APE (Sox) extract had a significantly higher total flavonoid content, APA (Mac) extract had a high total phenolic content, and APA (Sox) extract had a high total tannin content. Read More

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The effect of high-risk HPV E6/E7 mRNA on the efficacy of topical photodynamic therapy with 5-aminolevulinic acid for cervical high-grade squamous intraepithelial lesions.

Photodiagnosis Photodyn Ther 2022 Jun 17:102974. Epub 2022 Jun 17.

Department of Gynecology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address:

Background: E6 and E7 high-risk human papillomavirus (HR-HPV) oncoproteins are closely associated with the initiation and progression of cervical cancer (CC) and pre-cancerous lesions. Cervical high-grade squamous intraepithelial lesions (HSIL), as pre-cancerous lesions, have a 5% chance of progressing to invasive cancer. Topical 5-aminolevulinic acid photodynamic therapy (ALA-PDT) is a novel non-invasive targeted therapy for intraepithelial lesions. Read More

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Extensive HPV Genotyping Reveals High Association between Multiple Infections and Cervical Lesions in Chinese Women.

Dis Markers 2022 10;2022:8130373. Epub 2022 Jun 10.

Department of Pathology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200090, China.

Objective: The relationship between human papillomavirus (HPV) and cervical lesions has been extensively elucidated, but infection with multiple genotypes is less investigated due to methodology limitations. In the current study, with a method of genotyping 21 HPVs in a routine cervical screening population, we aimed to investigate the prevalence and diversity of HPV infections in Chinese women and further evaluate the impact of multiple infections of HPV on cervical lesion progression.

Methods: Totally, 73,596 patients who underwent 21-genotype HPV testing from January 2018 to April 2019 were retrieved from the database of the Department of Pathology, Obstetrics and Gynecology Hospital of Fudan University. Read More

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The prognostic value of chemotherapy or/and radiotherapy in adenoid cystic carcinoma and adenoid basal carcinoma of the uterine cervix.

Ann Transl Med 2022 May;10(10):554

Department of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Jinan, China.

Background: Cervical adenoid cystic carcinoma (ACC) and adenoid basal carcinoma (ABC) are rare cervical cancer types and have unclarified clinicopathological features and survival outcomes. This retrospective study focused on predicting the value of radiotherapy or/and chemotherapy for cervical ACC and ABC patients.

Methods: The clinical data of cervical ACC and ABC patients in the Surveillance, Epidemiology, and End Results (SEER) database from 1973 and 2013 were included. Read More

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Body Weight Is a Valid Predictor of the Long-Term Prognosis of Cervical Cancer.

Comput Math Methods Med 2022 8;2022:5613350. Epub 2022 Jun 8.

Department of Obstetrics and Gynecology, 2nd Affiliated Hospital of Harbin Medical University, China.

Objective: To identify and validate effective clinical predictors for the long-term prognosis of patients with cervical cancer.

Methods: Cervical cancer patients were retrieved from the TCGA database, and patients' clinical data were collected and analyzed for the predictive value of long-term prognosis. In the other branch of the study, patients with cervical cancer and admitted to our hospital between January 1, 2016, and December 31, 2016, were retrieved and followed up for prognosis analysis. Read More

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[Preparation and effect against cervical cancer invasion in vitro of harmine-loaded photosensitive liposomes].

Zhongguo Zhong Yao Za Zhi 2022 May;47(10):2643-2651

Pharmacy School/Key Laboratory of Xinjiang Phytomedicine Resources and Utilization, Ministry of Education, Shihezi University Shihezi 832000, China School of Pharmacy/Key Laboratory of Sichuan Province for Specific Structure of Small Molecule Drugs, Chengdu Medical College Chengdu 610500, China.

Despite the development of HPV vaccines and screening programs, cervical cancer is still a serious threat to women's health. Early-stage cervical cancer is mainly treated by surgery. However, considering the serious complications after surgery, hyperthermia is recommended to enhance the effect of chemotherapy, retain the integrity of cervix, improve the treatment effect, which provides a therapeutic basis for the early treatment of cervical cancer. Read More

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HPV vaccination associated with decreased cervical cancer incidence and mortality.

Rachel Caskey

J Pediatr 2022 Jun;245:246-249

University of Illinois at Chicago, Chicago, Illinois.

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Cisplatin-associated ototoxicity: perspectives from a single institution cervical cancer cohort and implications for developing a locally responsive monitoring programme in a public healthcare setting.

BMC Health Serv Res 2022 Jun 18;22(1):791. Epub 2022 Jun 18.

African Cancer Institute, Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University, P.O. Box 241, Cape Town, 8000, South Africa.

Background: Ototoxicity monitoring is uncommon in South Africa, despite the increased use of ototoxic medication to manage the burden of disease in the country. The successful implementation of such a protocol requires cognisance of contextual realities and multiple dimensions for consideration from both patients and service providers. As part of an ongoing cohort study on cisplatin-associated ototoxicity and efforts to better inform the implementation of such programmes, the perspectives of cervical cancer patients and healthcare workers towards ototoxicity monitoring were assessed. Read More

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Fertility-sparing surgery in early-stage cervical cancer: laparoscopic versus abdominal radical trachelectomy.

BMC Womens Health 2022 06 18;22(1):241. Epub 2022 Jun 18.

Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, People's Republic of China.

Background: Radical trachelectomy is an acceptable alternative to radical hysterectomy for patients with early-stage cervical cancer who wish to preserve reproductive function. This study is designed to compare the laparoscopic versus abdominal radical trachelectomy and provide oncological and obstetric outcome data on patients who have undergone fertility-sparing surgery.

Methods: We retrospectively analyzed all early-stage cervical cancer patients who underwent abdominal radical trachelectomy (ART) or laparoscopic radical trachelectomy (LRT) between January 2005 and June 2017 in West China Second University Hospital, Sichuan University. Read More

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X-Linked Inhibitor of Apoptosis Protein (XIAP)-Loaded Magnetic Mesoporous Silica Nanoparticles Incorporated with miR-233 to Improve Radio Sensitization of Cervical Cancer Cells and Promote Apoptosis.

J Biomed Nanotechnol 2022 Mar;18(3):747-753

Department of Radiation Oncology, The Second Affiliated Hospital of Xian Jiaotong University, Xi'an City, Shanxi Province, 710003, China.

This study investigated the impact of magnetic mesoporous silica nanoparticles (MMSN)-encapsulated X-linked inhibitor of apoptosis protein (XIAP) and miR-233 on tumor microenvironment in cervical cancer, to provide targeted treatment and strategy, to improve radio sensitization of cancer cells. Cervical cancer cells were treated with normal saline (control group), XIAP-loaded metallic mesoporous silica nanoparticles (MMSNs), and miR-233-targeted material (XIAP group, XIAP+miR-233 group). Proliferation, apoptosis and colony forming ability of cancer cells were assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method, flow cytometry and colony formation experiments. Read More

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