79,843 results match your criteria Cervix Cancer


TET1 promotes 5hmC-dependent stemness, and inhibits a 5hmC-independent epithelial-mesenchymal transition, in cervical precancerous lesions.

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

Translational Epigenetics Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

DNA hypermethylation is a driving force in carcinogenesis. However, the role of active DNA hypomethylation in cancer remains largely unknown. This process, facilitated by ten-eleven translocation methylcytosine dioxygenase 1 (TET1), which oxidizes 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), has never been studied in cervical cancer. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.01.033DOI Listing
February 2019

Influence of 18F-FDG-PET/CT on staging of cervical cancer.

Nuklearmedizin 2019 Feb 15;58(1):17-22. Epub 2019 Feb 15.

Chair and Department of Electroradiology, Poznan University of Medical Science.

Aim: Cervical cancer is one of the most common cancers of the female reproductive system. The aim of the study was to assess the usefulness of the F-FDG-PET/CT study in staging of cervical cancer, with focus on the primary tumor parameters.

Material & Methods: 105 patients (mean age 56 ± 11y) with newly diagnosed cervical cancer underwent PET/CT examination which was performed 60 min after IV injection of F-FDG with a mean activity of 364 ± 75MBq. Read More

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http://dx.doi.org/10.1055/a-0809-4577DOI Listing
February 2019

First radical trachelectomy with pelvic lymphadenectomy in El Salvador.

Int J Gynecol Cancer 2019 Feb 13. Epub 2019 Feb 13.

Ginecologia Oncologica, Hospital Nacional de la Mujer, San Salvador 00503, El Salvador

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http://dx.doi.org/10.1136/ijgc-2019-000235DOI Listing
February 2019

Sentinel lymph node mapping using indocyanine green in patients with uterine and cervical neoplasms: restrictions of the method.

Arch Gynecol Obstet 2019 Feb 14. Epub 2019 Feb 14.

Department of Cardiology, Institute of Mother and Child, Warsaw, Poland.

Purpose: To establish the surgical, demographic and histopathological factors associated with inaccurate sentinel lymph nodes (SLNs) identification using indocyanine green (ICG) and near-infrared (NIR) fluorescence imaging in uterine and cervical neoplasms during both open and laparoscopic surgery.

Methods: We reviewed patients with atypical endometrial hyperplasia (AEH), clinical stage I and II cervical cancer or uterine malignancies who underwent primary surgery with SLN mapping between September 2015 and January 2018. An analysis of patients' demographics, tumor factors and surgical approach was conducted. Read More

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http://dx.doi.org/10.1007/s00404-019-05063-6DOI Listing
February 2019

Cytological features of uterine tumors resembling ovarian sex-cord tumors in liquid-based cervical cytology: a potential pitfall. Report of a unique and rare case.

Diagn Cytopathol 2019 Feb 13. Epub 2019 Feb 13.

Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.

Uterine tumors resembling ovarian sex-cord tumors (UTROSCTs) are rare uterine neoplasms of uncertain etiology that resemble the sex cord tumors of the ovary and display a combined sex cord, epithelial, and smooth muscle immunophenotype. Most tumors are associated with a benign clinical course. We report the first cytological description of uterine UTROSCTs in liquid-based cervical cytology (LBC). Read More

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http://dx.doi.org/10.1002/dc.24153DOI Listing
February 2019

The distribution and prevalence of human papillomavirus in women in mainland China.

Cancer 2019 Feb 12. Epub 2019 Feb 12.

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.

We conducted a systematic review of the epidemiology of high-risk human papillomavirus (HPV) infections in mainland Chinese women to provide a general profile for the application and subsequent effectiveness evaluation of HPV vaccines. The PubMed, Web of Science, Medline (Ovid), China National Knowledge Infrastructure, and Wanfang databases were used for the literature search. The epidemiological studies published from January 2000 to June 2018 on high-risk HPVs in mainland Chinese women were investigated to systematically evaluate their epidemiological status. Read More

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http://doi.wiley.com/10.1002/cncr.32003
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http://dx.doi.org/10.1002/cncr.32003DOI Listing
February 2019
2 Reads

HPV as a marker for molecular characterization in head and neck oncology: Looking for a standardization of clinical use and of detection method(s) in clinical practice.

Head Neck 2019 Feb 12. Epub 2019 Feb 12.

Infections and Cancer Biology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France.

Background: A consensus about the most appropriate diagnostic method(s) for head and neck human papillomavirus (HPV)-induced carcinogenesis is still lacking because most of the commercially available assays have been designed for the cervix.

Methods: This article summarizes current data and trends concerning HPV diagnostic strategies in oropharyngeal squamous cell carcinoma (OPSCC). Six main approaches are described. Read More

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http://dx.doi.org/10.1002/hed.25591DOI Listing
February 2019

Synthesis and potential antineoplastic activity of dehydroabietylamine imidazole derivatives.

Medchemcomm 2018 Dec 12;9(12):2091-2099. Epub 2018 Nov 12.

College of Forestry , Nanjing Forestry University , Nanjing 210037 , PR China . Email:

To seek more efficient and lower toxicity anticancer compounds, several imidazole combining dehydroabietylamine derivatives including organic salts ( - ) and amides ( - ) were synthesized. Their antineoplastic activity against HeLa (cervix), MCF-7 (breast), A549 (lung) and HepG2 (liver) cells and HUVECs (umbilical vein, normal cells) were evaluated by MTT assay. The results unequivocally showed that nearly all compounds had better antineoplastic activity and lower toxicity than dehydroabietylamine ( ). Read More

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http://dx.doi.org/10.1039/c8md00487kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336084PMC
December 2018
2 Reads

Molecular Genetic Study to Detect Prevalence of High-risk Human Papilloma Virus Strains (type 16 and 18) in Cervical Lesions and Asymptomatic Healthy Subjects of Rural Central India.

J Cytol 2019 Jan-Mar;36(1):32-37

Department of Anatomy, Cytogenetic and Molecular Genetic Division, Mahatma Gandhi Institute of Medical Sciences, Wardha, Maharashtra, India.

Background: Carcinoma cervix of uterus (CaCx) is the most common malignancy affecting women worldwide. It is an established fact that infection of specific types of human papilloma virus (HPV) is essential for the development of cervical cancer. The present study reports the high-risk viruses (HPV 16 and 18) type distribution in rural central India, which has unique climatic condition. Read More

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http://dx.doi.org/10.4103/JOC.JOC_10_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343400PMC
February 2019
2 Reads

Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1-2 trial.

Lancet Oncol 2019 Feb 7. Epub 2019 Feb 7.

Department of Oncology, Phase 1 Unit, Rigshospitalet, Copenhagen, Denmark.

Background: Tisotumab vedotin is a first-in-human antibody-drug conjugate directed against tissue factor, which is expressed across multiple solid tumour types and is associated with poor clinical outcomes. We aimed to establish the safety, tolerability, pharmacokinetic profile, and antitumour activity of tisotumab vedotin in a mixed population of patients with locally advanced or metastatic (or both) solid tumours known to express tissue factor.

Methods: InnovaTV 201 is a phase 1-2, open-label, dose-escalation and dose-expansion study done at 21 centres in the USA and Europe. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30859-3DOI Listing
February 2019
1 Read

Factors associated with deformation accuracy and modes of failure for MRI-optimized cervical brachytherapy using deformable image registration.

Brachytherapy 2019 Feb 7. Epub 2019 Feb 7.

Department of Radiation Oncology, University of California Davis Comprehensive Cancer Center, Sacramento, CA. Electronic address:

Purpose: To identify factors associated with MRI-to-CT image deformation accuracy and modes of failure for MRI-optimized intracavitary high-dose-rate treatment of locally advanced cervical cancer.

Methods And Materials: Twenty-six patients with locally advanced cervical cancer had preimplantation MRI registered and deformed to postimplantation CT images using anatomically constrained and biomechanical model-based deformable image registration (DIR) algorithms. Cervix (primary) and cervix plus 10-mm margin (secondary) were used as controlling regions of interest for deformation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15384721183068
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http://dx.doi.org/10.1016/j.brachy.2019.01.001DOI Listing
February 2019
2 Reads

Asian Society of Gynecologic Oncology International Workshop 2018.

J Gynecol Oncol 2019 Jan 14. Epub 2019 Jan 14.

Department of Obstetrics and Gynecology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea.

The Asian Society of Gynecologic Oncology International Workshop 2018 on gynecologic oncology was held in the Ajou University Hospital, Suwon, Korea on the 24th to 25th August 2018. The workshop was an opportunity for Asian doctors to discuss the latest findings of gynecologic cancer, including cervical, ovarian, and endometrial cancers, as well as the future of fertility-sparing treatments, minimally invasive/radical/debulking surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy. Clinical guidelines and position statement of Asian countries were presented by experts. Read More

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https://ejgo.org/DOIx.php?id=10.3802/jgo.2019.30.e39
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http://dx.doi.org/10.3802/jgo.2019.30.e39DOI Listing
January 2019
2 Reads

Minimally invasive surgery improves short-term outcomes of nerve-sparing radical hysterectomy in patients with cervical cancer: a propensity-matched analysis with open abdominal surgery.

J Gynecol Oncol 2018 Nov 27. Epub 2018 Nov 27.

Department of Gynecologic Oncology, IRCCS National Cancer Institute, Milan, Italy.

Objectives: Nerve-sparing radical hysterectomy has been implemented in order to reduce pelvic floor dysfunctions in women undergoing radical surgery for cervical cancer. Here, we aimed to investigate if the adoption of laparoscopic surgery impacts on patients' outcomes.

Methods: Data of consecutive patients affected by cervical cancer who had laparoscopic nerve-sparing radical hysterectomy were matched 1:1 with an historical cohort of patients undergoing open procedure. Read More

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http://dx.doi.org/10.3802/jgo.2019.30.e27DOI Listing
November 2018
2 Reads

Clinically diagnosed primary transitional cell carcinoma of the colon: A case report.

Int J Surg Case Rep 2019 Jan 31;55:168-170. Epub 2019 Jan 31.

Division of Surgery, Hiraka General Hospital, Yokote, Akita, Japan.

Introduction: Most transitional cell carcinomas (TCCs) occur in the urinary tract. There are no reports of TCC originating in the colon. This report presents a very rare case of TCC that primarily occurred in the colon. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.01.035DOI Listing
January 2019
1 Read

The value of pretreatment serum butyrylcholinesterase level as a novel prognostic biomarker in patients with cervical cancer treated with primary (chemo-)radiation therapy.

Strahlenther Onkol 2019 Feb 8. Epub 2019 Feb 8.

Department for Gynecology and Gynecologic Oncology, Gynecologic Cancer Unit, Comprehensive Cancer Centre, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Background: Deficiency in butyrylcholinesterase (BChE), a condition commonly noticed in liver damage, inflammation, and malnutrition, has previously been associated with impaired prognosis in different malignancies. The aim of the present study was to investigate the value of pretreatment serum BChE levels as a prognostic biomarker in patients with cervical cancer treated with primary (chemotherapy-[chemo-])radiation therapy.

Methods: We retrospectively evaluated data of a consecutive series of patients with cervical cancer treated with primary (chemo-)radiation therapy between 1998 and 2015. Read More

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http://dx.doi.org/10.1007/s00066-019-01430-zDOI Listing
February 2019
1 Read

-mutated clear cell cervical cancer associated with in-utero diethylstilbestrol exposure.

Gynecol Oncol Rep 2019 May 29;28:15-17. Epub 2019 Jan 29.

Division of Gynecologic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

We report an extraordinary case of a woman, exposed to diethylstilbestrol in utero, who developed clear cell adenocarcinoma of the cervix with a concurrent polymerase-Ɛ () somatic mutation. The tumor exhibited the classic phenotypic characteristics of -mutated tumors originating from other organs (e.g. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23525789193001
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http://dx.doi.org/10.1016/j.gore.2019.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357694PMC
May 2019
2 Reads

A Novel Approach of Mathematical Theory of Shape and Neuro-Fuzzy Based Diagnostic Analysis of Cervical Cancer.

Pathol Oncol Res 2019 Feb 6. Epub 2019 Feb 6.

Department of Electronics and Communication Sciences Unit, Indian Statistical Institute, Kolkata, West Bengal, Pin-700108, India.

This study aims to detect the abnormal growth of tissue in cervix region for diagnosis of cervical cancer using Pap test of patients. The proposed methodology classifies cervical cancer for pattern recognition either benign or malignant stages using shape and neuro-fuzzy based diagnostic model. In this experiment, firstly the authors segment Pap smear images of cervical cells using fuzzy c-means clustering algorithm and shape theory to classify them according to the presence of abnormality of the cells. Read More

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http://dx.doi.org/10.1007/s12253-019-00582-8DOI Listing
February 2019

Chemoradiotherapy for locally advanced cervix cancer without aortic lymph node involvement: can we consider metabolic parameters of pretherapeutic FDG-PET/CT for treatment tailoring?

Eur J Nucl Med Mol Imaging 2019 Feb 7. Epub 2019 Feb 7.

Department of Surgical Oncology, IUCT-Oncopole, 1 avenue Irène Joliot-Curie, 31059, Toulouse Cedex 9, France.

Purpose: Aim of the study was to assess impact of pretherapeutic FDG-PET/CT metabolic parameters on response to chemoradiotherapy (CRT) and survival in locally advanced cervical cancer (LACC) patients without paraaortic lymph node involvement.

Methods: LACC patients treated with CRT without macrometastatic involvement after paraaortic surgical staging were included. All patients had received at least 45 Gy radiotherapy and five cycles of platinum-based chemotherapy. Read More

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http://dx.doi.org/10.1007/s00259-018-4219-5DOI Listing
February 2019
1 Read

A mobile-phone based high-resolution microendoscope to image cervical precancer.

PLoS One 2019 6;14(2):e0211045. Epub 2019 Feb 6.

Department of Bioengineering, Rice University, Houston, Texas, United States of America.

Nearly 90% of cervical cancer cases and deaths occur in low- and middle-income countries that lack comprehensive national HPV immunization and cervical cancer screening programs. In these settings, it is difficult to implement screening programs due to a lack of infrastructure and shortage of trained personnel. Screening programs based on visual inspection with acetic acid (VIA) have been successfully implemented in some low-resource settings. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211045PLOS
February 2019
5 Reads

Small cell carcinoma of cervix: A population-based study evaluating standardized provincial treatment protocols.

Gynecol Oncol Rep 2019 Feb 9;27:54-59. Epub 2019 Jan 9.

University of British Columbia, British Columbia, Canada.

Objectives: To describe the patient characteristics, patterns of treatment, and outcome of patients with small cell carcinoma of Cervix (SmCC) treated with radical radiotherapy from a provincial cancer registry database.

Methods: Overall 25 patients with SmCC were treated with radical radiotherapy (with or without chemotherapy) from January 1, 1994 to December 31, 2013. Nineteen patients had pure SmCC while 6 had additional neuroendocrine component. Read More

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http://dx.doi.org/10.1016/j.gore.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348692PMC
February 2019

Promoter hypermethylation of SOX11 promotes the progression of cervical cancer in vitro and in vivo.

Oncol Rep 2019 Feb 1. Epub 2019 Feb 1.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China.

The development of cervical cancer (CC) is a multi‑gene, multi‑step carcinogenic process that involves complex genetic and epigenetic mechanisms. SRY‑related HMG‑box gene 11 (SOX11) is a member of the SOX family of transcription factors with an emerging crucial role in the development of various tumor types. To elucidate the function of SOX11 in cervical carcinogenesis, the expression level of SOX11 during the development of human CC was analyzed by immunohistochemistry and western blot analysis. Read More

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http://dx.doi.org/10.3892/or.2019.6993DOI Listing
February 2019
2 Reads

Comparison of PapilloCheck and Linear Array to Detect and Differentiate Human Papillomaviruses in Cervical and Tonsillar Smears from Females with Cervical Intraepithelial Lesions.

Eur J Microbiol Immunol (Bp) 2018 Dec 12;8(4):107-111. Epub 2018 Dec 12.

Department of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Germany.

A subgroup of oropharyngeal squamous cell carcinomas (OSCCs) are causally linked to infection with high-risk human papillomaviruses (HR-HPVs). To evaluate the prevalence of simultaneous oral HPV infection in females with cervical high-grade squamous intraepithelial lesions (HSIL), tonsillar- and cervical smears were collected simultaneously from 73 patients and analyzed for HPV using two commercial assays, PapilloCheck (Greiner-Bio-One) and Linear Array (Roche). Only 3/73 (4. Read More

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https://www.akademiai.com/doi/10.1556/1886.2018.00018
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http://dx.doi.org/10.1556/1886.2018.00018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348707PMC
December 2018
3 Reads

Essential TNM: a registry tool to reduce gaps in cancer staging information.

Lancet Oncol 2019 Feb;20(2):e103-e111

Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada; Union for International Cancer Control, Geneva, Switzerland.

Accurate information on the extent of disease around the time of diagnosis is an important component of cancer care, in defining disease prognosis, and evaluating national and international cancer control policies. However, the collection of stage data by population-based cancer registries remains a challenge in both high-income and low and middle-income countries. We emphasise the lack of availability and comparability of staging information in many population-based cancer registries and propose Essential TNM, a simplified staging system for cancer registries when information on full Tumour, Node, Metastasis (TNM) is absent. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14702045183089
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http://dx.doi.org/10.1016/S1470-2045(18)30897-0DOI Listing
February 2019
6 Reads

Adaptive color deconvolution for histological WSI normalization.

Comput Methods Programs Biomed 2019 Mar 15;170:107-120. Epub 2019 Jan 15.

Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.

Background And Objective: Color consistency of histological images is significant for developing reliable computer-aided diagnosis (CAD) systems. However, the color appearance of digital histological images varies across different specimen preparations, staining, and scanning situations. This variability affects the diagnosis and decreases the accuracy of CAD approaches. Read More

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http://dx.doi.org/10.1016/j.cmpb.2019.01.008DOI Listing

Magnetic resonance imaging after external beam radiotherapy and concurrent chemotherapy for locally advanced cervical cancer helps to identify patients at risk of recurrence.

Int J Gynecol Cancer 2019 Feb 1. Epub 2019 Feb 1.

Department of Surgical Oncology, Institut Claudius Regaud - Institut Universitaire du Cancer Toulouse - Oncopole, Toulouse, France

Objective: Tumor volume and regression after external beam radiotherapy have been shown to be accurate parameters to assess treatment response via magnetic resonance imaging (MRI). The aim of the study was to evaluate the prognostic value of tumor size reduction rate after external beam radiotherapy and chemotherapy prior to brachytherapy.

Methods: Patients with locally advanced cervical cancer treated at two French comprehensive cancer centers between 1998 and 2010 were included. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000168DOI Listing
February 2019
1 Read

Current state of sentinel lymph nodes for women with endometrial cancer.

Authors:
Emma C Rossi

Int J Gynecol Cancer 2019 Feb 1. Epub 2019 Feb 1.

University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

Sentinel lymph node (SLN) biopsy has been investigated as an alternative to conventional pelvic and para-aorticlymphadenectomy for the surgical staging of endometrial cancer. Clinical trials have established the accuracy of sentinel nodes in the detecting metastatic disease. Novel advancements in tracers from the historically favored blue dyes and radio labeled colloids to near infrared imaging of fluorescent dyes has improved the ability to detect sentinel nodes and increased options for surgeons. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000075DOI Listing
February 2019
1 Read

Chronic uterine inversion with malignancy mimicking carcinoma cervix.

BMJ Case Rep 2019 Feb 1;12(2). Epub 2019 Feb 1.

Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, Delhi, India.

Chronic non-puerperal uterine inversion is a rare event, with only a handful of cases reported in literature. We report a case of a 64-year-old postmenopausal woman who presented with complaints of mass per vaginam and postmenopausal bleeding. On examination, she appeared to have third-degree cervical descent with an irregular growth seen over what appeared to be the cervix, biopsy of which showed keratinising squamous cell carcinoma. Read More

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http://dx.doi.org/10.1136/bcr-2018-225541DOI Listing
February 2019
1 Read

Analysis of gastric-type mucinous carcinoma of the uterine cervix - An aggressive tumor with a poor prognosis: A multi-institutional study.

Gynecol Oncol 2019 Jan 29. Epub 2019 Jan 29.

Department of Obstetrics and Gynecology, Kurume University School of Medicine, Kurume, Japan.

Objective: Gastric-type mucinous carcinoma (GAS) is a novel variant of mucinous carcinoma of the uterine cervix. As shown in the original Japanese group description, in recent studies, GAS represents a more aggressive disease than the usual-type endocervical adenocarcinoma (UEA). Detailed clinicopathological features of this variant remain to be elucidated in a larger series of patients. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.01.022DOI Listing
January 2019
1 Read

A case of primary signet-ring cell carcinoma of the cervix containing full genome of human papillomavirus 16.

Indian J Pathol Microbiol 2019 Jan-Mar;62(1):146-148

Department of Obstetrics and Gynecology, School of Medicine, Fujita Health University, Tokyo 208-0011, Japan.

We herein present a case of primary signet-ring cell carcinoma of the cervix. Pelvic magnetic resonance imaging revealed a 38-mm cervical tumor, and computed tomography revealed no findings suggestive of distal metastasis or other tumor origins. Gastrointestinal endoscopy showed no abnormal findings. Read More

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http://www.ijpmonline.org/text.asp?2019/62/1/146/251259
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http://dx.doi.org/10.4103/IJPM.IJPM_507_17DOI Listing
February 2019
2 Reads
0.642 Impact Factor

Cervical Cancer and Its Precursors: A Preventative Approach to Screening, Diagnosis, and Management.

Prim Care 2019 Mar 22;46(1):117-134. Epub 2018 Dec 22.

Department of Obstetrics and Gynecology, University of California, Davis, Davis, CA, USA.

Cervical cancer affects the cells lining the cervix, most commonly occurring in the cells of the transformation zone. Screening for cervical cancer looks to detect preinvasive disease, allowing for intervention before invasive disease develops. an assessment of individual risk factors, Selection of screening method depends on patient age, her screening history and results, and resources available. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00954543183009
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http://dx.doi.org/10.1016/j.pop.2018.10.011DOI Listing
March 2019
9 Reads

The cost-effectiveness of implementing HPV testing for cervical cancer screening in El Salvador.

Int J Gynaecol Obstet 2019 Jan 31. Epub 2019 Jan 31.

Center for Health Decision Science, Department of Health Policy and Management, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Objective: To assess the cost-effectiveness of HPV-based screening and management algorithms for HPV-positive women in phase 2 of the Cervical Cancer Prevention in El Salvador (CAPE) demonstration, relative to the status quo of Pap-based screening.

Methods: Data from phase 2 of the CAPE demonstration (n=8000 women) were used to inform a mathematical model of HPV infection and cervical cancer. The model was used to project the lifetime health and economic outcomes of HPV testing every 5 years (age 30-65 years), with referral to colposcopy for HPV-positive women; HPV testing every 5 years (age 30-65 years), with immediate cryotherapy for eligible HPV-positive women; and Pap testing every 2 years (age 20-65 years), with referral to colposcopy for Pap-positive women. Read More

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http://doi.wiley.com/10.1002/ijgo.12773
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http://dx.doi.org/10.1002/ijgo.12773DOI Listing
January 2019
3 Reads

Allergies and the subsequent risk of cancer among elderly adults in the United States.

Cancer Epidemiol Biomarkers Prev 2019 Jan 30. Epub 2019 Jan 30.

Division of Cancer Epidemiology and Genetics, National Cancer Institute.

Background: Allergic conditions may prevent some cancers by promoting immune surveillance. We examined associations of allergic rhinitis, asthma, and eczema with cancer risk among elderly Americans.

Methods: We used Surveillance, Epidemiology, and End Results (SEER)-Medicare linked data to perform a case-control study. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0887DOI Listing
January 2019
2 Reads

Prevalence of high-risk human papilloma virus in women with high-grade squamous cell intraepithelial lesions in Botswana using Abbott RealTime HPV assay.

PLoS One 2019 30;14(1):e0211260. Epub 2019 Jan 30.

Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.

Background: High-risk human papillomavirus (HR-HPV) has been demonstrated to be the necessary cause of cervical carcinoma. High-risk HPV detection has a prognostic significance for the women who are at increased risk of disease progression. HPV genotyping in cervical cancer precursor lesions is crucial for prevention and management of cervical cancer. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211260PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353155PMC
January 2019
5 Reads

Clinical evaluation and treatment of chronic bowel symptoms following cancer in the colon and pelvic organs.

Acta Oncol 2019 Jan 30:1-6. Epub 2019 Jan 30.

a Danish Cancer Society Centre for Research on Survivorship and Late Adverse Effects After Cancer in the Pelvic Organs , Aarhus University Hospital , Aarhus , Denmark.

Background: Chronic gastrointestinal symptoms are common among patients surviving surgery and/or radio-/chemotherapy for cancer in the pelvic organs. However, little is known about the pathophysiology behind symptoms or the effect of treatment. The aim of the present study was to present the results of clinical evaluation and treatment of patients with chronic bowel symptoms after treatment for cancer in the colon or pelvic organs. Read More

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https://www.tandfonline.com/doi/full/10.1080/0284186X.2018.1
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http://dx.doi.org/10.1080/0284186X.2018.1562211DOI Listing
January 2019
4 Reads

High-grade endometrial stromal sarcoma: a retrospective study of factors influencing prognosis.

Cancer Manag Res 2019 17;11:831-837. Epub 2019 Jan 17.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China,

Objectives: The aim of this study was to evaluate the factors associated with progress-free survival (PFS) and overall survival (OS) in patients with high-grade endometrial stromal sarcoma (HG-ESS).

Patients And Methods: A total of 40 patients were enrolled in this study at the Peking Union Medical College Hospital, Beijing, China, from 2006 to 2016. The study retrospectively analyzed clinical and pathological data, and associations of these variables with PFS and OS were evaluated. Read More

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http://dx.doi.org/10.2147/CMAR.S187849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340498PMC
January 2019
2 Reads

Mesenchymal stromal cells derived from normal cervix and cervical cancer tumors increase CD73 expression in cervical cancer cells through TGF-β1 production.

Stem Cells Dev 2019 Jan 30. Epub 2019 Jan 30.

Instituto Mexicano del Seguro Social, Laboratorio de Inmunología y Cáncer. UIMEO, H Oncología, CMN SXXI, Ciudad de México, Mexico.

Mesenchymal stromal cells (MSCs) in the tumor microenvironment (TME) participate together with tumor cells to suppress antitumor effector cells through the production of immunosuppressive factors such as TGF-β1. Furthermore, TGF-β1 can induce 5'-nucleotidase (CD73) expression in various cell types; this functional activity is associated with the production of adenosine (Ado), which is an immunosuppressive nucleoside. In this study, we provide evidence that coculture of MSCs derived from cervical tumors (CeCa-MSC) with CeCa tumor cells increases CD73 expression in tumor cells and the capacity of these cells to generate Ado in a MSC-ratio-dependent manner. Read More

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http://dx.doi.org/10.1089/scd.2018.0183DOI Listing
January 2019

[Application and clinical significance of Silva pattern system in invasive endocervical adenocarcinoma].

Zhonghua Fu Chan Ke Za Zhi 2019 Jan;54(1):13-18

Department of Pathology, School of Basic Medical Sciences, Third Hospital, Peking University Health Science Center, Beijing 100191, China.

To investigate the significance of Silva pattern system about clinical application in invasive endocervical adenocarcinoma. Data obtained from the Maternity Affiliated Hospital of Dalian Medical University was analyzed, 78 endocervical adenocarcinoma cases were included from December, 2006 to August, 2017. The average age of patients was (45. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2019.01.004DOI Listing
January 2019
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[Clinicopathological analysis of cervical basaloid squamous cell carcinoma].

Zhonghua Fu Chan Ke Za Zhi 2019 Jan;54(1):7-12

Department of Pathology, General Hospital of PLA, Beijing 100853, China.

To investigate the clinical and histopathological features of cervical basal squamous cell carcinoma (BSCC). A retrospective analysis of 10 cases of cervical BSCC was carried out. The clinical data and all the pathological sections were reviewed, the related immunohistochemical results were statistically analyzed, the clinicopathological features were analyzed, and then followed the prognosis. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2019.01.003DOI Listing
January 2019
8 Reads

Calculation of dose volume parameters and indices in plan evaluation of HDR interstitial brachytherapy by MUPIT in carcinoma cervix.

Indian J Cancer 2018 Jul-Sep;55(3):238-241

Department of Radiotherapy, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India.

Background: Evaluation of a HDR- interstitial brachytherapy plan is a challenging job. Owing to the complexities and diversity of the normalization and optimization techniques involved, a simple objective assessment of these plans is required. This can improve the radiation dose coverage of the tumour with decreased organ toxicity. Read More

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http://dx.doi.org/10.4103/ijc.IJC_643_17DOI Listing
January 2019
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A dosimetric comparison between applicators used for brachytherapy in carcinoma cervix - A single-institute prospective study.

Indian J Cancer 2018 Jul-Sep;55(3):230-232

Department of Radiation Oncology, Basavatarakam Indo American Hospital and Research Institute, Hyderabad, Telangana, India.

Introduction: Cervical cancer is the second most common cancer among Indian women. Radical radiotherapy with external beam radiation therapy (EBRT) and brachytherapy is the standard treatment for FIGO stage IB2 to IVA. An appropriate selection of brachytherapy applicator is needed according to the patient's anatomy. Read More

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http://dx.doi.org/10.4103/ijc.IJC_659_17DOI Listing
January 2019
1 Read

Combined antitumoral effects of pretubulysin and methotrexate.

Pharmacol Res Perspect 2019 02 22;7(1):e00460. Epub 2019 Jan 22.

Pharmaceutical Biotechnology Center for System-Based Drug Research, and Center for Nanoscience (CeNS) Ludwig-Maximilians-Universität Munich Germany.

Pretubulysin (PT), a potent tubulin-binding antitumoral drug, and the well-established antimetabolite methotrexate (MTX) were tested separately or in combination (PT+MTX) for antitumoral activity in L1210 leukemia cells or KB cervix carcinoma cells in vitro and in vivo in NMRI-nu/nu tumor mouse models. In cultured L1210 cells, treatment with PT or MTX displays strong antitumoral effects in vitro and the combination PT+MTX exceeds the effect of single drugs. PT also potently kills the MTX resistant KB cell line, without significant MTX combination effect. Read More

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http://doi.wiley.com/10.1002/prp2.460
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http://dx.doi.org/10.1002/prp2.460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343018PMC
February 2019
7 Reads

Cervical Cytopathological Changes Associated with Onset of Menopause.

J Midlife Health 2018 Oct-Dec;9(4):180-184

Department of Community Medicine, Era's Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India.

Background: In the life of a woman, after 40 years of age, onset of menopause occurs during which hormonal imbalances take place. The present study is aimed at finding out cytopathological changes in the cervical epithelium associated with this hormonal disturbance.

Materials And Methods: Cervical cancer screening program is in progress under auspices of Era's Lucknow Medical College and Hospital, Lucknow, since May 2013, in the villages of Lucknow West through camp approach. Read More

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http://www.jmidlifehealth.org/text.asp?2018/9/4/180/249148
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http://dx.doi.org/10.4103/jmh.JMH_4_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332728PMC
January 2019
3 Reads

Mechanical characterization and ex vivo evaluation of anticancer and antiviral drug printed bioadhesive film for the treatment of cervical cancer.

Eur J Pharm Sci 2019 Jan 25;130:114-123. Epub 2019 Jan 25.

Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, 06100, Sıhhiye, Ankara, Turkey.

As research progresses on personalized medicines, it is clear that personalized and flexible formulations can provide effective treatment with reduced side effects especially for diseases like cancer, characteristic of high patient variability. 2D and 3D printers are frequently reported in the literature for the preparation of pharmaceutical products with adjusted dose and selected drug combinations. However, in-depth characterization studies of these formulations are rather limited. Read More

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http://dx.doi.org/10.1016/j.ejps.2019.01.030DOI Listing
January 2019
1 Read

Preparedness of Young Girls for Prevention of Cervical Cancer and Strategy to introduce the HPV Vaccine.

Indian J Community Med 2018 Dec;43(Suppl 1):S38-S41

Department of Community Medicine and Family Medicine, AIIMS, Bhubaneswar, Odisha, India.

Objective: Cervical cancer incidence and mortality rates remain high in developing country due to low levels of awareness on preventive measures. The main study objective was to sensitize the young girls on the prevention of cervical cancer.

Study Design: Quasi-experimental pretest and posttest design was used. Read More

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http://dx.doi.org/10.4103/ijcm.IJCM_14_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324042PMC
December 2018
2 Reads

Cancer Screening and Prevention Highlights in Gynecologic Cancer.

Obstet Gynecol Clin North Am 2019 Mar;46(1):19-36

Division of Gynecology Oncology, Department of Obstetrics and Gynecology, University of Virginia, University of Virginia Medical Center, PO Box 800712, Charlottesville, VA 22908, USA.

This article provides an up-to-date summary of screening approaches and key strategies in prevention of gynecologic malignancies. The Pap smear is the only proven screening intervention in the field of gynecologic oncology. Women should receive treatment for precancerous conditions of the cervix, vulva, vagina, and endometrial lining. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08898545183009
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http://dx.doi.org/10.1016/j.ogc.2018.09.002DOI Listing
March 2019
4 Reads

Screening capacity and cost-effectiveness of the human papillomavirus test versus cervicography as an adjunctive test to Pap cytology to detect high-grade cervical dysplasia.

Eur J Obstet Gynecol Reprod Biol 2019 Jan 17;234:112-116. Epub 2019 Jan 17.

Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, Republic of Korea.

Objective: This study compared the screening capacities and cost-effectiveness of the human papillomavirus (HPV) test versus cervicography as an adjunctive test to Papanicolaou (Pap) cytology to detect high-grade cervical neoplasia in Korea, a country with a high prevalence of cervical cancer.

Study Design: Of 33,531 Korean women who underwent cervicography as a screening test for cervical cancer between January 2015 and December 2016, we retrospectively analyzed the records of 4117 women who simultaneously or subsequently underwent Pap cytology, an HPV test, cervicography, and colposcopically directed biopsy. At a threshold of cervical intraepithelial neoplasia grade 2 or worse (CIN2+), based on colposcopic biopsy, we compared the diagnostic capacities and cost-effectiveness of these screening tools. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.01.008DOI Listing
January 2019
1 Read
1.627 Impact Factor

Efficacy of robotic radical hysterectomy for cervical cancer compared with that of open and laparoscopic surgery: A separate meta-analysis of high-quality studies.

Medicine (Baltimore) 2019 Jan;98(4):e14171

Department of Obstetrics and Gynecology, Women's Hospital, Zhejiang University of Medicine, Hangzhou, Zhejiang Province, China.

Background: To perform a meta-analysis of high-quality studies comparing robotic radical hysterectomy (RRH) vs laparoscopic radical hysterectomy (LRH), and open radical hysterectomy (ORH) for the treatment of cervical cancer.

Methods: A systematic search of PubMed, Embase, Cochrane Library, and Web of Science was performed to identify studies that compared RRH with LRH or ORH. The selection of high-quality, nonrandomized comparative studies was based on a validated tool (methodologic index for nonrandomized studies) since no randomized controlled trials have been published. Read More

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http://dx.doi.org/10.1097/MD.0000000000014171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358398PMC
January 2019

Non-human Papillomavirus Cervical Mucinous Adenocarcinoma in a Phenotypic Male with Congenital Adrenal Hyperplasia.

Cureus 2018 Nov 18;10(11):e3607. Epub 2018 Nov 18.

Obstetrics and Gynecology, University of Minnesota, Minneapolis, USA.

A majority of cervical cancers are caused by human papillomavirus (HPV); however, HPV-negative cervical cancers exist and, though rare, are more aggressive. No prior reports examine HPV-negative cancer of the cervix in a female pseudohermaphrodite with congenital adrenal hyperplasia (CAH). This is a case of a 78-year-old phenotypic male with hypospadias and absent testicles who presented with urinary retention and urosepsis. Read More

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http://dx.doi.org/10.7759/cureus.3607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338395PMC
November 2018