84,297 results match your criteria Cervix Cancer


Switches of SOX17 and SOX2 expression in the development of squamous metaplasia and squamous intraepithelial lesions of the uterine cervix.

Cancer Med 2020 Jul 9. Epub 2020 Jul 9.

Department of Molecular Cell Biology, GROW School for Oncology & Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.

Aims: The dynamics and topographical distribution of SOX17 and SOX2 expression was studied in the transformation zone (TZ) of the uterine cervix. This TZ is a dynamic area where switches from glandular into squamous epithelium can be recognized, new squamocolumnar junctions are formed, and premalignant lesions originate. SOX17 and SOX2 show mutually exclusive expression patterns in the normal uterine cervix, with SOX2 being exclusively found in squamous epithelium, while SOX17 is detected in endocervical columnar cells and reserve cells. Read More

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http://dx.doi.org/10.1002/cam4.3201DOI Listing

Lineage Analysis of Human Papillomavirus Type 18 based on E6 Region in Cervical Samples of Iranian Women.

J Med Virol 2020 Jul 9. Epub 2020 Jul 9.

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Distinct HPV 18 variants are thought to differ in oncogenic potential and geographic distribution. As such, understanding the regional variants of HPV 18 would be of great importance for evolutionary, epidemiological, and biological analysis. In this regard, the sequence variations of E6 gene were investigated to characterize more common variants of HPV 18 in normal cells, premalignant, and malignant samples collected from the cervix. Read More

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http://dx.doi.org/10.1002/jmv.26283DOI Listing

Malignant Melanoma of the Female Genital Tract: Experience of an Oncology Center in Pakistan.

Cureus 2020 Jun 7;12(6):e8484. Epub 2020 Jun 7.

Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, PAK.

Introduction Malignant melanoma, which arises from melanocytes or pigment cells, is one of the most common forms of epithelial cancer. Cutaneous and noncutaneous melanomas differ clinically and genetically. Mucosal melanomas are rare. Read More

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http://dx.doi.org/10.7759/cureus.8484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336621PMC

Genetic characteristics of gastric-type mucinous carcinoma of the uterine cervix.

Mod Pathol 2020 Jul 8. Epub 2020 Jul 8.

Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.

Gastric-type mucinous carcinoma (GAS) is a recently established variant of endocervical mucinous adenocarcinoma that is characterized as being unrelated to HPV and having aggressive behavior and chemoresistance. GAS has a distinct morphology resembling nonneoplastic gastric glands or pancreaticobiliary adenocarcinoma, and their possible genetic similarity has been posed. In this study, next-generation sequencing was performed in 21 GAS cases using a customized panel including 94 cancer-associated genes. Read More

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http://dx.doi.org/10.1038/s41379-020-0614-0DOI Listing

Epitope Mapping and Computational Analysis of Anti-HPV16 E6 and E7 Antibodies in Single-Chain Format for Clinical Development as Antitumor Drugs.

Cancers (Basel) 2020 Jul 6;12(7). Epub 2020 Jul 6.

Department of Infectious Diseases, Istituto Superiore di Sanità, 00161 Rome, Italy.

Human Papillomavirus 16-associated cancer, affecting primarily the uterine cervix but, increasingly, other body districts, including the head-neck area, will long be a public health problem, despite there being a vaccine. Since the virus oncogenic activity is fully ascribed to the viral E6 and E7 oncoproteins, one of the therapeutic approaches for HPV16 cancer is based on specific antibodies in single-chain format targeting the E6/E7 activity. We analyzed the Complementarity Determining Regions, repositories of antigen-binding activity, of four anti-HPV16 E6 and -HPV16 E7 scFvs, to highlight possible conformity to biophysical properties, recognized to be advantageous for therapeutic use. Read More

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http://dx.doi.org/10.3390/cancers12071803DOI Listing

Invited Commentary: Rethinking Cervical Cancer Elimination in Terms of Lifetime Risk Rather Than Arbitrarily-Defined Age-Standardized Incidence Rates.

Am J Epidemiol 2020 Jul 8. Epub 2020 Jul 8.

Division of Cancer Epidemiology, Department of Oncology, McGill University, Montréal, Québec, Canada.

Vänskä et al. (Am J Epidemiol. XXXX;XXX(XX):XXXX-XXXX)) provide us with cohort lifetime risks of cervical cancer attributable to different human papillomavirus (HPV) types in Sweden. Read More

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http://dx.doi.org/10.1093/aje/kwaa120DOI Listing

Cost-effectiveness of HPV-based cervical screening based on first year results in the Netherlands : A modelling study.

BJOG 2020 Jul 7. Epub 2020 Jul 7.

Erasmus MC, University Medical Center Rotterdam, Department of Public Health, Rotterdam, The Netherlands.

Objective: We aim to compare the cost-effectiveness of the old cytology programme with the new high-risk human papillomavirus (hrHPV) screening programme, using performance indicators from the new Dutch hrHPV screening programme.

Design: Model-based cost-effectiveness analysis.

Setting: The Netherlands. Read More

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http://dx.doi.org/10.1111/1471-0528.16400DOI Listing

Measurement of tumor size in early cervical cancer: an ever-evolving paradigm.

Int J Gynecol Cancer 2020 Jul 6. Epub 2020 Jul 6.

Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

The major tenets in accurately assessing tumor size in patients with early stage cervical cancer currently include physical examination, imaging studies, and pathologic evaluation. It is estimated that when comparing clinical stage based on physical examination and final pathology, the concordance diminishes as stage increases: 85.4%, 77. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001436DOI Listing

[Update for Diagnosis and Management of HPV-Driven Oropharyngeal Cancer].

Praxis (Bern 1994) 2020 Jul;109(9):697-703

Klinik für Ohren-, Nasen-, Hals- und Gesichtschirurgie, Universitätsspital Zürich.

Update for Diagnosis and Management of HPV-Driven Oropharyngeal Cancer In the past decades, an increasing incidence of oropharyngeal squamous cell cancer could be observed. More than twenty years ago, a correlation between a pharyngeal Human papillomavirus high-risk type infection and the development of oropharyngeal cancer has been suspected. Especially younger patients without the former risk factors smoking and alcohol have a higher prevalence for this cancer type. Read More

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http://dx.doi.org/10.1024/1661-8157/a003484DOI Listing

Ensemble Deep Learning for Cervix Image Selection toward Improving Reliability in Automated Cervical Precancer Screening.

Diagnostics (Basel) 2020 Jul 3;10(7). Epub 2020 Jul 3.

Communications Engineering Branch, Lister Hill National Center for Biomedical Communications, U.S. National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.

Automated Visual Examination (AVE) is a deep learning algorithm that aims to improve the effectiveness of cervical precancer screening, particularly in low- and medium-resource regions. It was trained on data from a large longitudinal study conducted by the National Cancer Institute (NCI) and has been shown to accurately identify cervices with early stages of cervical neoplasia for clinical evaluation and treatment. The algorithm processes images of the uterine cervix taken with a digital camera and alerts the user if the woman is a candidate for further evaluation. Read More

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http://dx.doi.org/10.3390/diagnostics10070451DOI Listing

Impact of intracavitary brachytherapy technique (2D versus 3D) on outcomes of cervical cancer: a systematic review and meta-analysis.

Strahlenther Onkol 2020 Jul 6. Epub 2020 Jul 6.

Department of Radiation Oncology, Asan Medical Center, University of Ulsan, College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, 05505, Seoul, Korea (Republic of).

Purpose: To perform a systematic review and meta-analysis of the impact of brachytherapy (BT) technique (two-dimensional [2D] or three-dimensional image-guided [3D]) on outcomes of cervical cancer patients.

Methods: PubMed and EMBASE databases were searched up to April 16, 2019, for studies which evaluated the effect of 3D-BT compared to 2D-BT in cervical cancer. Endpoints included cumulative incidence of severe toxicity, locoregional recurrence-free survival (LRRFS), progression-free survival (PFS), and overall survival (OS). Read More

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http://dx.doi.org/10.1007/s00066-020-01658-0DOI Listing

Hand metastasis in a patient with cervical cancer: A case report.

Medicine (Baltimore) 2020 Jul;99(27):e20897

Department of Clinical Research, National Cancer Institute.

Introduction: Acrometastasis is infrequent and generally indicates a wider spread of metastasis with poor prognosis. The diagnosis is challenging, as it might mimic an infectious, inflammatory, or metabolic disease. Acrometastasis are most commonly found in patients with lung, gastrointestinal, kidney, and breast cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000020897DOI Listing

The effect of Medicaid expansion among adults from low-income communities on stage at diagnosis in those with screening-amenable cancers.

Cancer 2020 Jul 6. Epub 2020 Jul 6.

Center for Community Health Integration, Case Western Reserve University School of Medicine, Cleveland, Ohio.

Background: Several states have opted to expand Medicaid under the Patient Protection and Affordable Care Act (ACA), which offers insurance coverage to low-income individuals up to 138% of the federal poverty level. This expansion of Medicaid to a medically vulnerable population potentially can reduce cancer outcome disparities, especially among patients with screening-amenable cancers. The objective of the current study was to estimate the effect of Medicaid expansion on the percentage of adults from low-income communities with screening-amenable cancers who present with metastatic disease. Read More

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http://dx.doi.org/10.1002/cncr.32895DOI Listing

COVID 19 vaccination lessons from Japanese anti-HPV vaccination lobby.

Int J Gynecol Cancer 2020 Jul 5. Epub 2020 Jul 5.

Royal Women's Hospital, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1136/ijgc-2020-001712DOI Listing

Performing gynecologic cancer surgery during the COVID-19 pandemic in Turkey: A multicenter retrospective observational study.

Int J Gynaecol Obstet 2020 Jul 4. Epub 2020 Jul 4.

Medeniyet University, Department of Obstetrics and Gynecology, Gynecologic Oncology Division, Istanbul, Turkey.

Objective: To report the perioperative outcomes of 200 patients with gynecologic cancer who underwent surgery during the Novel Coronavirus Disease (COVID-19) pandemic and the safety of surgical approach.

Methods: Data of patients operated between March 10 and May 20, 2020, were collected retrospectively. Data were statistically analyzed using IBM Statistical Package for the Social Sciences (SPSS) Statistics for Windows v. Read More

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http://dx.doi.org/10.1002/ijgo.13296DOI Listing

Detection of human papillomavirus distinguishes second primary tumors from lung metastases in patients with squamous cell carcinoma of the cervix.

Thorac Cancer 2020 Jul 3. Epub 2020 Jul 3.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

Background: In patients with squamous cell carcinoma of the cervix (SCCC), a squamous cell carcinoma (SqCC) in the lung represents either a second primary tumor or metastasis. This distinction between second primary tumors and lung metastases in patients with SCCC significantly influences patient prognosis and therapy. Here, we aimed to differentiate second primary tumors from lung metastases in patients with SCCC by exploring the HPV status in SqCCs involving the lung within a large cohort. Read More

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http://dx.doi.org/10.1111/1759-7714.13544DOI Listing

Antiproliferative effect of bacterial cyclodipeptides in the HeLa line of human cervical cancer reveals multiple protein kinase targeting, including mTORC1/C2 complex inhibition in a TSC1/2-dependent manner.

Apoptosis 2020 Jul 2. Epub 2020 Jul 2.

Laboratorio de Biotecnología Microbiana, Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, 58030, Morelia, Michoacán, México.

Cervix adenocarcinoma rendered by human papillomavirus (HPV) integration is an aggressive cancer that occurs by dysregulation of multiple pathways, including oncogenes, proto-oncogenes, and tumor suppressors. The PI3K/Akt/mTOR pathway, which cross-talks with the Ras-ERK pathway, has been associated with cervical cancers (CC), which includes signaling pathways related to carcinoma aggressiveness, metastasis, recurrence, and drug resistance. Since bacterial cyclodipeptides (CDPs) possess cytotoxic properties in HeLa cells with inhibiting Akt/S6k phosphorylation, the mechanism of CDPs cytotoxicity involved was deepened. Read More

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http://dx.doi.org/10.1007/s10495-020-01619-zDOI Listing

Genes Regulated by HPV 16 E6 and High Expression of NFX1-123 in Cervical Cancers.

Onco Targets Ther 2020 26;13:6143-6156. Epub 2020 Jun 26.

Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.

Purpose: High-risk human papillomaviruses (HR HPV) cause cervical cancer, and in these cancers, HPV type 16 is the most common HR type. The HR viral oncogenes E6 and E7 partner with cellular proteins to drive cancer and modulate immune pathways; previously, we demonstrated in keratinocytes that HPV 16 E6 and high expression of the endogenous host protein partner NFX1-123 led to the increased expression of multiple genes, including Notch1, secretory leukocyte peptidase inhibitor (SLPI), and retinoic acid early transcript 1G (RAET1G). The present study was conducted to determine if NFX1-123 was highly expressed in cervical cancer and if genes increased by NFX1-123 and 16E6 in keratinocytes were also increased in cervical cancers. Read More

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http://dx.doi.org/10.2147/OTT.S251926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326398PMC

Risk of second primary cancers among survivors of gynecological cancers.

Gynecol Oncol 2020 Jun 29. Epub 2020 Jun 29.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 1201 11th Ave S, Birmingham, AL 35205, USA.

Objective: Survivors of gynecologic cancers have an increased risk of developing second primary cancers (SPC); however it is unclear which sites have higher risks. We aimed to ascertain risk of SPC among survivors of gynecological cancer, and identify anatomic sites at risk of SPC.

Methods: We queried the Surveillance, Epidemiology and End Results database (2000-2016) for confirmed cases of index gynecological (cervix uteri [cervical], corpus and uterus [endometrial], ovarian, vaginal, and vulvar) cancers. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.06.492DOI Listing

Comparative transcriptomic profiling in HPV-associated cervical carcinogenesis: Implication of MHC class II and immunoglobulin heavy chain genes.

Life Sci 2020 Jun 29:118026. Epub 2020 Jun 29.

Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Minden, Pulau Pinang, Malaysia. Electronic address:

Aim: We aimed to determine the biological processes and pathways involved in cervical carcinogenesis associated with high-risk human papillomavirus (HPV) infection.

Materials And Methods: Total RNA was extracted from three formalin-fixed paraffin-embedded (FFPE) samples each of normal cervix, HPV-infected low-grade squamous intraepithelial lesion (LSIL), high-grade SIL (HSIL) and squamous cell carcinoma (SCC). Transcriptomic profiling by microarrays was conducted followed by downstream Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118026DOI Listing

Association between Common Vaginal Infections and Cervical Non-HPV16/18 Infection in HPV-Vaccinated Women.

J Infect Dis 2020 Jul 2. Epub 2020 Jul 2.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.

Background: How vaginal infections like bacterial vaginosis (BV), Candida spp., and Trichomonas vaginalis (TV) affect persistence of human papillomavirus (HPV) infection is not well established. Our study aimed to evaluate the association between common vaginal infections and cervical non-HPV16/18 infection, as risk factors associated with persistence of non-vaccine HPV types will become increasingly relevant in the setting of HPV vaccination. Read More

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http://dx.doi.org/10.1093/infdis/jiaa384DOI Listing

Paper spray ionization mass spectrometry as a potential tool for early diagnosis of cervical cancer.

J Am Soc Mass Spectrom 2020 Jul 2. Epub 2020 Jul 2.

Squamous intraepithelial lesion is an abnormal growth of epithelial cells on the surface of the cervix that may lead to cervi-cal cancer. Analytical protocols for the determination of squamous intraepithelial lesions are highly demanded since cervical cancer is the fourth most diagnosed cancer among women in the world. Here, paper spray ionization mass spectrometry (PSI-MS) is used to distinguish between healthy (negative for intraepithelial lesion or malignancy) and diseased (high-grade squamous intraepithelial lesion) blood plasmas. Read More

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http://dx.doi.org/10.1021/jasms.0c00111DOI Listing

Factors Associated with Treatment Uptake Among Women with Acetic Acid/Lugol's Iodine Positive Lesions of the Cervix in Cameroon.

Int J Womens Health 2020 25;12:495-504. Epub 2020 Jun 25.

College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA, USA.

Purpose: Treatment of cervical precancer is the primary aim in secondary prevention of cervical cancer. The purpose of this study was to examine factors associated with treatment uptake among women with acetic acid/Lugol's iodine positive lesions identified by digital cervicography (DC) in a cervical cancer prevention program in Cameroon.

Patients And Methods: We conducted a cross-sectional survey of medical records from 2013 to 2018 of 755 women in Cameroon who screened positive with acetic acid/Lugol's iodine in 2013. Read More

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http://dx.doi.org/10.2147/IJWH.S249607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323798PMC

Interpreting body MRI cases: classic findings in pelvic MRI.

Abdom Radiol (NY) 2020 Jun 30. Epub 2020 Jun 30.

Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, PA, USA.

The high contrast resolution provided by magnetic resonance imaging (MRI) compared to all other modalities allows the interpreting radiologist to make a specific diagnosis for many common and uncommon findings. In some cases, the diagnosis can be so certain that there is no differential diagnosis. In this article, we review the most classically recognized findings when interpreting MRI of the pelvis including the following: Ovaries: Simple cyst, hemorrhagic cyst, corpus luteum, dermoid, fibroma/fibrothecoma. Read More

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http://dx.doi.org/10.1007/s00261-020-02615-2DOI Listing

Radical Hysterectomy for Cervical Cancer in Patients With Uterine Prolapse.

In Vivo 2020 Jul-Aug;34(4):2073-2078

Department of Surgery, "Ponderas" Academic Hospital, Bucharest, Romania.

Background/aim: Association between cervical cancer and uterine prolapse represents a scarce eventuality. This is a case series of 11 patients diagnosed with different stages of cervical cancer in association with uterine prolapse.

Patients And Methods: Between 2014 and 2020, 11 patients were diagnosed with cervical cancer on prolapsed uterine cervix. Read More

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http://dx.doi.org/10.21873/invivo.12010DOI Listing

Radiotherapy dose escalation on pelvic lymph node control in patients with cervical cancer.

Int J Gynecol Cancer 2020 Jun 30. Epub 2020 Jun 30.

Department of Radiation Medicine, Northwell Health, Lake Success, New York, USA

Objective: Data supporting dose escalation for node-positive cervical cancer are currently limited to small retrospective studies. The goal of this study was to assess whether radiation dose was associated with lymph node control or gastrointestinal toxicity in patients with node-positive cervical cancer.

Methods: A total of 390 patients with carcinoma of the uterine cervix were treated between October 1997 and October 2017. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001342DOI Listing

Cervical Cancer Mortality in East-Central European Countries.

Int J Environ Res Public Health 2020 Jun 28;17(13). Epub 2020 Jun 28.

Department of Oncologic Gynecology and Obstetrics, The Center of Postgraduate Medical Education, 00-416 Warsaw, Poland.

Changes that took place in Europe in the early 1990s had an impact on health-associated issues. They were an impulse for the changes in healthcare systems and, consequently, also for the changes in cancer control programmes. Those changes also had an effect on mortality rates due to cervical cancer (CC). Read More

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http://dx.doi.org/10.3390/ijerph17134639DOI Listing

Downregulation of IL-2 and IL-23 in Cervical Biopsies of Cervical Intraepithelial Lesions: A Cross-Sectional Study.

Acta Cytol 2020 Jun 29:1-10. Epub 2020 Jun 29.

Gynecology and Obstetrics Department, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil,

Introduction: Persistent infection with high-risk human papillomavirus (HPV) types is associated with high-grade intraepithelial lesions (HSILs) and invasive cervical cancer. The host immune response plays a key role in whether HPV clears or persists. Most studies on local immune response to HPV collect cervical mucus in order to quantify secreted cytokines; however, cells located inside the tissue can release different cytokines associated with HPV infection. Read More

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http://dx.doi.org/10.1159/000508015DOI Listing

First report of compounds from an species: Triterpenoids from Oliv. (Malvaceae).

Nat Prod Res 2020 Jun 29:1-3. Epub 2020 Jun 29.

Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon.

The stem bark of Oliv. exhibited triterpenoids, including the rare fernane-type, fern-9(11)-ene-2α,3β-diol () a possible chemotaxonomically distinct biomolecule for the genus. Other triterpenoids that were isolated from this plant include the ursane-type ursolic acid () and corosolic acid (), friedelane-type friedelin () and canophyllol (), lupane-type lupeol (), betulin (), betulinic acid () and hennadiol (), oleanoic acid (), maslinic acid () and taraxerol () and three sterols. Read More

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http://dx.doi.org/10.1080/14786419.2020.1782408DOI Listing

Health disparities in cervical cancer: Prevalence of high-risk HPV and cytologic diagnoses according to race.

Cancer Cytopathol 2020 Jun 29. Epub 2020 Jun 29.

Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland.

Background: In the United States, the rate of cervical cancer is disproportionally higher in Hispanic and black women compared with white women. In the current study, the authors compared human papillomavirus (HPV) testing and cytology results among black and white women over a 24-month period. They then assessed the rates in young women in 2011 compared with 2017 according to race. Read More

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http://dx.doi.org/10.1002/cncy.22316DOI Listing

Multimodality therapy of endometrial glassy cell carcinoma: a rare type of cancer.

BMJ Case Rep 2020 Jun 28;13(6). Epub 2020 Jun 28.

Department of Hematology Oncology, Dana Farber Cancer Institute, St Elizabeth's Medical Center, Boston, Massachusetts, USA.

Glassy cell carcinoma (GCC) is a rare histologically aggressive cancer subtype of the cervix that is associated with poor prognosis. Only 16 cases of endometrial GCC (EGCC) have been described in the literature to date. The data on prognostic factors and management of EGCC are limited and no optimal treatment protocol has been established. Read More

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http://dx.doi.org/10.1136/bcr-2020-235164DOI Listing

A biomechanical finite element model to generate a library of cervix CTVs.

Med Phys 2020 Jun 27. Epub 2020 Jun 27.

Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Purpose: To generate a series of physiologically plausible cervix CTVs by biomechanically modeling organ deformation as a consequence of bladder filling. This series can serve as planning CTVs for radiotherapy treatment of cervical cancer patients using a library of plans (LoP) strategy.

Methods: The model was constructed based on the full and empty bladder scans of 20 cervical cancer patients, for which the bladder, cervix, uterus and rectum were delineated. Read More

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http://dx.doi.org/10.1002/mp.14349DOI Listing

Perineural spread of clear cell adenocarcinoma of müllerian origin resulting in neoplastic lumbosacral plexopathy.

World Neurosurg 2020 Jun 24. Epub 2020 Jun 24.

Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota. Electronic address:

Background: Adenocarcinomas of müllerian origin are malignancies derived from tissues of the proximal third of the vagina, cervix, uterus and fallopian tubes. These organs develop from the embryologic müllerian ducts. While reports of perineural spread of certain uterine and cervical carcinomas exist in the literature, to our knowledge, no reports of clear cell type müllerian adenocarcinoma presenting with neural invasion of the lumbosacral plexus exist in the literature. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.121DOI Listing

Sociodemographic inequalities in the uptake of Papanicolaou tests in Peru: Analysis of the Demographic and Family Health Survey 2015-2017.

Epidemiol Health 2020 Jun 18:e2020043. Epub 2020 Jun 18.

Universidad Científica del Sur, Lima, Peru.

Objectives: To analyze the inequalities in Papanicolaou test uptake according to the sociodemographic characteristics of Peruvian women 30 to 59 years of age using information from the 2015-2017 Demographic and Family Health Survey (ENDES, acronym in Spanish).

Methods: This is an analytical, cross-sectional study based on information acquired from the 2015-2017 ENDES surveys. Sociodemographic characteristics were reported using absolute frequencies and weighted proportions with a 95% confidence interval, considering. Read More

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http://dx.doi.org/10.4178/epih.e2020043DOI Listing

Results of a Phase I-II Study on Laser Therapy for Vaginal Side Effects after Radiotherapy for Cancer of Uterine Cervix or Endometrium.

Cancers (Basel) 2020 Jun 21;12(6). Epub 2020 Jun 21.

Gynecologic Oncology Unit, Sant'Orsola-Malpighi Hospital, 40138 Bologna, Italy.

Women who have previously received radiotherapy (RT) for gynecologic cancer often suffer from vaginal fibrosis and stenosis. The success of "non-ablative" laser therapy for postmenopausal vaginal atrophy has led to the idea of testing the laser in patients submitted to RT. In this prospective observational study, we selected patients who underwent pelvic RT followed by vaginal laser treatment. Read More

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http://dx.doi.org/10.3390/cancers12061639DOI Listing

Difference in characteristics and outcomes of basaloid squamous cell carcinoma and squamous cell carcinoma, usual type in cervix: A population-based study from SEER 18 database.

Asia Pac J Clin Oncol 2020 Jun 23. Epub 2020 Jun 23.

Pathology Department, National Cancer Center, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Aim: Cervical basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma with little recognition. Our objective was to identify difference in characteristics and outcomes between BSCC and squamous cell carcinoma, usual type (SSC, UT).

Methods: A total of 32 BSCC patients and 6387 SCC, UT patients, diagnosed from 2004 to 2014, were identified using the Surveillance, Epidemiology, and End Results database. Read More

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http://dx.doi.org/10.1111/ajco.13383DOI Listing

SIX1 cooperates with RUNX1 and SMAD4 in cell fate commitment of Müllerian duct epithelium.

Cell Death Differ 2020 Jun 22. Epub 2020 Jun 22.

Department of Cancer Biology and Genetics, The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.

During female mammal reproductive tract development, epithelial cells of the lower Müllerian duct are committed to become stratified squamous epithelium of the vagina and ectocervix, when the expression of ΔNp63 transcription factor is induced by mesenchymal cells. The absence of ΔNp63 expression leads to adenosis, the putative precursor of vaginal adenocarcinoma. Our previous studies with genetically engineered mouse models have established that fibroblast growth factor (FGF)/mitogen-activated protein kinase (MAPK), bone morphogenetic protein (BMP)/SMAD, and activin A/runt-related transcription factor 1 (RUNX1) signaling pathways are independently required for ΔNp63 expression in Müllerian duct epithelium (MDE). Read More

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http://dx.doi.org/10.1038/s41418-020-0579-zDOI Listing
June 2020
8.184 Impact Factor

Nuclear Morphology and the Biology of Cancer Cells.

Authors:
Edgar G Fischer

Acta Cytol 2020 Jun 22:1-9. Epub 2020 Jun 22.

Division of Surgical Pathology and Cytopathology, Department of Pathology, University of New Mexico, Albuquerque, New Mexico, USA,

Background: For more than a century, diagnostic pathologists have used morphologic abnormalities of the nucleus as essential diagnostic features to distinguish benign from malignant cells. These features include nuclear enlargement and increased nuclear-to-cytoplasmic ratio, nuclear membrane irregularities, hyperchromasia, and abnormal chromatin distribution. As our knowledge about the genetic and epigenetic abnormalities of cancer cells has increased in recent decades, the pathophysiologic mechanisms that underlie these morphologic abnormalities remain incompletely understood. Read More

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http://dx.doi.org/10.1159/000508780DOI Listing

Significant impact on the oncologic outcomes with intensity modulated radiotherapy and conformational radiotherapy over conventional radiotherapy in cervix cancer patients treated with radiotherapy.

Rep Pract Oncol Radiother 2020 Jul-Aug;25(4):678-683. Epub 2020 Jun 7.

Universidade de São Paulo (USP), Faculdade de Medicina de Ribeirão Preto da (FMRP), Ribeirão Preto, SP, Brazil.

Objective: We designed a retrospective cohort of women with cervix cancer treated by radiation therapy with an extended follow-up to evaluate if the incorporation of modern radiation techniques was a prognostic factor.

Material And Methods: We studied a cohort of patients with cervix cancer FIGO stage I-IVa treated in the last fifteen years. Patients were treated with radiotherapy alone (RT) or chemoradiation alone (CRT) using conventional radiotherapy (2DRT), conformational radiotherapy (3DRT), or intensity-modulated radiotherapy (IMRT) followed by high dose rate brachytherapy. Read More

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http://dx.doi.org/10.1016/j.rpor.2020.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298565PMC

Investigation of the survival viability of cervical cancer cells (HeLa) under visible light induced photo-catalysis with facile synthesized WO/ZnO nanocomposite.

Saudi J Biol Sci 2020 Jul 27;27(7):1743-1752. Epub 2020 Apr 27.

Medical Physics Unit, McGill University, Montreal, Canada.

The photo catalytic degradation, a proven chemical process used for the decontamination of organic/inorganic pollutants and microorganisms in water was implemented. In this work for the selective killing of cervical cancer cells () by using nano-composite of (Zinc Oxcide), (tungsten oxide) and () as a photo-catalyst under the irradiation of visible light. All the three nanostructured semiconducting materials (WO3, ZnO and n-WO3/ZnO) were synthesized by facile chemical precipitation method and their morphological and optical characterization studies were carried out to elucidate the observed enhancement in the photo-catalytic killing of HeLa cancer cells with n-WO3/ZnO as a photo-catalyst. Read More

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http://dx.doi.org/10.1016/j.sjbs.2020.04.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296502PMC

Activation of DNA damage repair factors in HPV positive oropharyngeal cancers.

Virology 2020 Aug 22;547:27-34. Epub 2020 May 22.

Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, IL, 60611, USA. Electronic address:

The mechanisms regulating viral pathogenesis of human papillomavirus (HPV) associated oropharyngeal squamous cell cancers (OPSCC) are not well understood. In the cervix, activation of DNA damage repair pathways is critical for viral replication but little is known about their role in OPSCC. APOBEC factors have been shown to be increased in OPSCC but the significance of this is unclear. Read More

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http://dx.doi.org/10.1016/j.virol.2020.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333731PMC

18F-Fluciclovine PET/MRI in a Patient With Squamous Cell Carcinoma of the Uterine Cervix Correlated With 18F-FDG PET/CT.

Clin Nucl Med 2020 Jun 17. Epub 2020 Jun 17.

Radiation Oncology, University of Pittsburgh, Pittsburgh, PA.

A 32-year-old woman with a FIGO (International Federation of Gynecology and Obstetrics) stage IIA invasive squamous cell carcinoma of the uterine cervix underwent a clinical FDG PET/CT scan, which revealed intense uptake in the primary. On research F-fluciclovine PET/MRI, the primary showed elevated fluciclovine uptake at 5 and 40 minutes after radiotracer injection, with no evidence of regional or distant metastasis. Fluciclovine PET may have diagnostic value for cervical cancer imaging with a potential advantage over FDG of minimal urinary activity from renal excretion; however, in this patient, the metabolic activity was inferior to that of FDG PET. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003139DOI Listing

Analysis of the surgical management of patients with recurrent cervical cancer after radiotherapy and chemotherapy.

Rev Col Bras Cir 2020 15;47:e20202443. Epub 2020 Jun 15.

Universidade de Cruz Alta, Cruz Alta, Biomedicina - Cruz Alta - RS - Brasil.

Objective: To analyze the results of morbidity and survival after curative and palliative surgery in recurrent cervical cancer patients who underwent chemoradiation as their primary treatment. Another goal was to assess the factors associated with curative and non-curative procedures.

Methods: This was a retrospective cohort consisting of patients undergoing surgery curative and palliative from January 2011 to December 2017 at a high complexity oncology center. Read More

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http://dx.doi.org/10.1590/0100-6991e-20202443DOI Listing

Level and Factors Associated with Participation in Population-Based Cancer Screening in Safranbolu District of Karabuk, Turkey.

Iran J Public Health 2020 Apr;49(4):663-672

Karabuk Public Health Directorate, Karabuk, Turkey.

Background: Cervix, breast and colorectal cancers are included in the national population-based screening (PBS) program in Turkey. This study aimed to assess participation in PBSs for these cancers and to identify factors associated with participation in screenings in Safranbolu district of Karabuk, Turkey in 2016-2017.

Methods: In this cross-sectional study, separate studying groups for cervix, breast and colorectal cancers were identified, taking into account the target age range specified in the national screening standards. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283187PMC
April 2020
0.576 Impact Factor

SOX10 - A Novel Marker for the Differential Diagnosis of Breast Metaplastic Squamous Cell Carcinoma.

Cancer Manag Res 2020 28;12:4039-4044. Epub 2020 May 28.

Department of Pathology, School of Basic Medical Science, Central South University, Changsha 410013, People's Republic of China.

Introduction: Differential diagnosis of metaplastic squamous cell carcinoma of breast (MSCCB) is difficult. In particular, in terms of metastatic MSCCB, because of the low speciality of traditional markers such as mammaglobin, gross cystic disease fluid protein-15 (GCDFP-15) and GATA binding protein 3 (GATA3), the most common problem is differentiating the spread of MSCCB to the lung from a primary lung squamous cell carcinoma. It is urgently required to explore a novel marker to aid in differential diagnosis. Read More

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http://dx.doi.org/10.2147/CMAR.S250867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266319PMC

Sentinel lymph node biopsy alone in the management of early cervical carcinoma.

Int J Gynecol Cancer 2020 Jun 16. Epub 2020 Jun 16.

Department of Mathematics and Applied Computation, University of Leicester, Leicester, Leicestershire, UK.

Objective: Sentinel lymph node (SLN) biopsy aims to assess lymph node status with reduced surgical morbidity. The aim of the study was to determine the accuracy and safety of SLN biopsy in the management of early cervical carcinoma using a double technique (technetium-99m (Tc-99m) nanocolloid and methylene blue dye injection).

Methods: This was a 10-year study from January 2009 to January 2019 that recruited 103 consecutive women undergoing surgery for early cervical carcinoma, FIGO 2009 stage IA1 (grade 3, and grade 2 with lymphovascular space invasion) to IB1 (<2 cm), at the West Kent Gynaecological Oncology Centre, Maidstone, UK. Read More

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http://dx.doi.org/10.1136/ijgc-2019-001082DOI Listing

Expression of Pregnancy Specific β-1 Glycoprotein 1 in Cervical Cancer Cells.

Arch Med Res 2020 Jun 13. Epub 2020 Jun 13.

Laboratorio de Oncología Genómica, Unidad de Investigación Médica en Enfermedades Oncológicas, Hospital de Oncología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México. Electronic address:

Background: Cervical Cancer (CC) is a worldwide public health concern associated with genetic alterations, among these the gain of the 19q chromosome harboring the Pregnancy Specific Glycoproteins (PSG) gene family. These proteins play a critical role in pregnancy, with participation in immunotolerance, angiogenesis, and invasion processes, which are also observed in carcinogenesis. The aim of this study was to determine the molecular alterations of PSG1 and its relationship with CC. Read More

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http://dx.doi.org/10.1016/j.arcmed.2020.05.025DOI Listing
June 2020
2.406 Impact Factor

Pharmacokinetic Properties of Ga-labelled Folic Acid Conjugates: Improvement Using HEHE Tag.

Molecules 2020 Jun 11;25(11). Epub 2020 Jun 11.

Department of Chemistry, Lomonosov Moscow State University, GSP-1, Leninskie Gory, 119991 Moscow, Russia.

The folate receptor (FR) is a promising cell membrane-associated target for molecular imaging and radionuclide therapy of cancer (FR-α) and potentially also inflammatory diseases (FR-β) through use of folic acid-based radioconjugate. FR is often overexpressed by cells of epithelial tumors, including tumors of ovary, cervix, endometrium, lungs, kidneys, etc. In healthy tissues, FR can be found in small numbers by the epithelial cells, mainly in the kidneys. Read More

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http://dx.doi.org/10.3390/molecules25112712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321154PMC