3,348 results match your criteria Cervicitis


B lymphocytes can be activated to act as antigen presenting cells to promote anti-tumor responses.

PLoS One 2018 5;13(7):e0199034. Epub 2018 Jul 5.

Department of Immunology, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.

Immune evasion by tumors includes several different mechanisms, including the inefficiency of antigen presenting cells (APCs) to trigger anti-tumor T cell responses. B lymphocytes may display a pro-tumoral role but can also be modulated to function as antigen presenting cells to T lymphocytes, capable of triggering anti-cancer immune responses. While dendritic cells, DCs, are the best APC population to activate naive T cells, DCs or their precursors, monocytes, are frequently modulated by tumors, displaying a tolerogenic phenotype in cancer patients. Read More

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July 2018
1 Read

Ureaplasma urealyticum: the Role as a Pathogen in Women's Health, a Systematic Review.

Curr Infect Dis Rep 2018 Jun 29;20(9):33. Epub 2018 Jun 29.

Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Hebrew University, Jerusalem, Israel.

Purpose Of Review: To evaluate the role of Ureaplasma urealyticum as a genital pathogen in women's health. Three aspects were analyzed: (1) preterm delivery (PTD); (2) female infertility; and (3) lower genital tract pathology including pelvic inflammatory disease (PID), cervicitis, and genital discomfort (discharge, burning).

Recent Findings: A systematic review was performed. Read More

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June 2018
2 Reads

Transcriptome Analysis of Neisseria gonorrhoeae during Natural Infection Reveals Differential Expression of Antibiotic Resistance Determinants between Men and Women.

mSphere 2018 Aug 27;3(3). Epub 2018 Jun 27.

Department of Immunology, Tufts University School of Medicine, Boston, Massachusetts, USA

is a bacterial pathogen responsible for the sexually transmitted infection gonorrhea. Emergence of antimicrobial resistance (AMR) of worldwide has resulted in limited therapeutic choices for this infection. Men who seek treatment often have symptomatic urethritis; in contrast, gonococcal cervicitis in women is usually minimally symptomatic, but may progress to pelvic inflammatory disease. Read More

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August 2018
1 Read

Sipi soup inhibits cancer‑associated fibroblast activation and the inflammatory process by downregulating long non‑coding RNA HIPK1‑AS.

Mol Med Rep 2018 Aug 6;18(2):1361-1368. Epub 2018 Jun 6.

Department of Acupuncture and Moxibustion, Longyan First Hospital, Longyan, Fujian 364000, P.R. China.

Sipi soup (SPS), the aqueous extract derived from the root bark of Sophora japonical L, Salix babylonica L., Morus alba L., as well as Amygdalus davidiana (Carr. Read More

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A prospective pilot evaluation of vaginal and urine self-sampling for the Roche cobas 4800 HPV test for cervical cancer screening.

Sci Rep 2018 Jun 13;8(1):9015. Epub 2018 Jun 13.

National Cancer Control Institute, National Cancer Center, Goyang, 10408, Republic of Korea.

This pilot study sought to evaluate the feasibility of utilizing vaginal self-swabs and urine samples for HPV-based cervical cancer screening in 700 women who had undergone conventional Pap smear screening via the national cervical cancer program in Korea. The cobas 4800 HPV test was utilized to detect HPV in the self-samples. Pap smear results revealed three cases of atypical squamous cells of undetermined significance, 649 cases of negative for an intraepithelial lesion or malignancy, and 48 non-specific inflammatory findings. Read More

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Applications of genomics to slow the spread of multidrug-resistant Neisseria gonorrhoeae.

Ann N Y Acad Sci 2018 Jun 6. Epub 2018 Jun 6.

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

Infections with Neisseria gonorrhoeae, a sexually transmitted pathogen that causes urethritis, cervicitis, and more severe complications, are increasing. Gonorrhea is typically treated with antibiotics; however, N. gonorrhoeae has rapidly acquired resistance to many antibiotic classes, and lineages with reduced susceptibility to the currently recommended therapies are emerging worldwide. Read More

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Outcomes of resistance-guided sequential treatment of Mycoplasma genitalium infections: a prospective evaluation.

Clin Infect Dis 2018 Jun 5. Epub 2018 Jun 5.

Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.

Background: Rising macrolide and quinolone resistance in Mycoplasma genitalium necessitate new treatment approaches. We evaluated outcomes of sequential antimicrobial therapy for M.genitalium guided by a macrolide-resistance assay. Read More

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June 2018
1 Read

BLT1-mediated O-GlcNAcylation is required for NOX2-dependent migration, exocytotic degranulation and IL-8 release of human mast cell induced by Trichomonas vaginalis-secreted LTB.

Microbes Infect 2018 Jun - Jul;20(6):376-384. Epub 2018 May 31.

Department of Environmental Medical Biology, Institute of Tropical Medicine, South Korea; Yonsei University College of Medicine, Seoul 120-752, South Korea. Electronic address:

Trichomonas vaginalis is a sexually-transmitted protozoan parasite that causes vaginitis and cervicitis. Although mast cell activation is important for provoking tissue inflammation during infection with parasites, information regarding the signaling mechanisms in mast cell activation and T. vaginalis infection is limited. Read More

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Expression of AMHR2 and C-KIT in cervical lesions in Uyghur Women of Xinjiang, China.

Medicine (Baltimore) 2018 Jun;97(22):e10793

Department of Histology and Embryology.

Background: Cervical cancer is one of the most common malignant tumors in women. Anti-Müllerian hormone receptor 2 (AMHR2) and C-Kit were two members of protein kinase which were reported increased in some cancers like ovarian carcinoma and breast cancer. The present study aimed to assess the expression of AMHR2 and c-Kit in cervical cancer of different differentiated degrees as well as in cervicitis sections. Read More

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June 2018
3 Reads

Common Sexually Transmitted Infections in Women.

Nurs Clin North Am 2018 Jun;53(2):189-202

Department of Family, Community, and Health Systems, University of Alabama at Birmingham School of Nursing, 1701 University Boulevard, Birmingham, AL 35294-1210, USA.

The spread of sexually transmitted infections (STIs) remains a significant public health issue in the United States. Social, economic, and behavioral implications affecting the spread of STIs have been identified. The most important social factor in the United States is the stigma associated with discussing sex and STI screening. Read More

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June 2018
5 Reads

An integrative investigation of the therapeutic mechanism of Ainsliaea fragrans Champ. in cervicitis using liquid chromatography tandem mass spectrometry based on a rat plasma metabolomics strategy.

J Pharm Biomed Anal 2018 Jul 27;156:221-231. Epub 2018 Apr 27.

Jiangxi University of Traditional Chinese Medicine, No. 818 Yunwan Road, Nanchang 330002, PR China; State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, No. 56 Yangming Road, Nanchang 330006, PR China. Electronic address:

Cervicitis is an extremely common gynecological disease and can be induced by diverse factors such as Neisseria gonorrhoeae, Chlamydia trachomatis, and Mycoplasma genitalium infections. Long-term unhealed cervicitis may lead to a series of diseases including endometritis, salpingitis, pelvic inflammatory disease, and chorioamnionitis. However, the pathogenesis of cervicitis remains unknown. Read More

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July 2018
2 Reads

Comparative Metabolomics Analysis of Cervicitis in Human Patients and a Phenol Mucilage-Induced Rat Model Using Liquid Chromatography Tandem Mass Spectrometry.

Front Pharmacol 2018 4;9:282. Epub 2018 Apr 4.

Jiangxi University of Traditional Chinese Medicine, Nanchang, China.

Cervicitis is an exceedingly common gynecological disorder that puts women at high risk of sexually transmitted infections and induces a series of reproductive system diseases. This condition also has a significant impact on quality of life and is commonly misdiagnosed in clinical practice due to its complicated pathogenesis. In the present study, we performed non-targeted plasma metabolomics analysis of cervicitis in both plasma samples obtained from human patients and plasma samples from a phenol mucilage induced rat model of cervicitis, using ultra-performance liquid chromatography coupled to quadrupole time-of-flight tandem mass spectrometry. Read More

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April 2018
1 Read

Assessing prevalence of missed laboratory-confirmed sexually transmitted infections among women in Kingston, Jamaica: results from a secondary analysis of the Sino-Implant clinical trial.

BMJ Open 2018 Apr 13;8(4):e019913. Epub 2018 Apr 13.

Division of Reproductive Health, U.S. Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.

Objectives: To assess potentially missed sexually transmitted infections (STIs), we compared clinically diagnosed STIs to laboratory-confirmed diagnoses of gonorrhoea (GC), chlamydia (CT) and trichomonas (Tvag).

Design: Secondary analysis of a randomised controlled trial.

Setting: We used data and specimens previously collected for the Sino-Implant Study in Kingston, Jamaica. Read More

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April 2018
7 Reads

Prevalence of and other sexually-transmitted pathogens among high-risk individuals in Greece.

Germs 2018 Mar 1;8(1):12-20. Epub 2018 Mar 1.

MD, PhD, FRCPath, Department of Microbiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Background: The aim of the present study was to determine the prevalence of (MG) infection among individuals at high risk for sexually-transmitted diseases (STDs) at a major urban STD clinic in Athens, in view of the lack of data pertaining to this infection in Greece.

Methods: Urethral and cervical samples from 176 individuals consecutively attending the clinic and agreeing to participate were prospectively collected and tested for MG infection using conventional PCR and TaqMan Real-Time PCR. All individuals were also examined for alternative STD pathogens. Read More

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[Prevalence and phylogenetic analysis of Chlamydia trachomatis in a population of women in Posadas, Misiones].

Rev Esp Quimioter 2018 Feb 16;31(1):21-26. Epub 2017 Feb 16.

Graciela Beatriz Jordá, Cátedra de Virología, Facultad de Ciencias Exactas, Químicas y Naturales, Universidad Nacional de Misiones. Luis Pasteur 1551. CP: 3300. Posadas, Misiones, Argentina.

Objective: Chlamydia trachomatis is the most prevalent bacteria causing sexually transmitted infections. In women, this infection can cause cervicitis and urethritis, although it's usually asymptomatic. The aim of this study was to investigate the prevalence of C. Read More

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February 2018
1 Read

Prevalence of in different population groups: systematic review andmeta-analysis.

Sex Transm Infect 2018 Jun 9;94(4):255-262. Epub 2018 Feb 9.

Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.

Background: is a common cause of non-gonococcal non-chlamydial urethritis and cervicitis. Testing of asymptomatic populations has been proposed, but prevalence in asymptomatic populations is not well established. We aimed to estimate the prevalence of in the general population, pregnant women, men who have sex with men (MSM), commercial sex workers (CSWs) and clinic-based samples, METHODS: We searched Embase, Medline, IndMED, African Index Medicus and LILACS from 1 January 1991 to 12 July 2016 without language restrictions. Read More

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June 2018
1 Read
3.40 Impact Factor

Ligneous cervicitis and endometritis: A gynaecological presentation of congenital plasminogen deficiency.

Haemophilia 2018 Feb 13. Epub 2018 Feb 13.

Department of Obstetrics and Gynaecology, The Royal Free Foundation NHS Trust, London, UK.

Background: Congenital plasminogen deficiency is a rare autosomal recessive condition. Plasminogen deficiency is thought to result in an inability of fibrin breakdown and therefore accumulation of fibrin and formation of ligneous changes. Ligneous lesions can form on a number of mucosal membranes including the cervix and endometrium. Read More

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February 2018
4 Reads
2.60 Impact Factor

Future of human Chlamydia vaccine: potential of self-adjuvanting biodegradable nanoparticles as safe vaccine delivery vehicles.

Expert Rev Vaccines 2018 Mar 6;17(3):217-227. Epub 2018 Feb 6.

a Department of Biological Sciences , Alabama State University , Montgomery , AL , USA.

Introduction: There is a persisting global burden and considerable public health challenge by the plethora of ocular, genital and respiratory diseases caused by members of the Gram-negative bacteria of the genus Chlamydia. The major diseases are conjunctivitis and blinding trachoma, non-gonococcal urethritis, cervicitis, pelvic inflammatory disease, ectopic pregnancy, tubal factor infertility, and interstitial pneumonia. The failures in screening and other prevention programs led to the current medical opinion that an efficacious prophylactic vaccine is the best approach to protect humans from chlamydial infections. Read More

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March 2018
7 Reads

Association between visual inspection of the cervix with acetic acid examination and high-risk human papillomavirus infection, Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis in Papua New Guinea.

Aust N Z J Obstet Gynaecol 2018 Jan 30. Epub 2018 Jan 30.

The Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.

Background: Papua New Guinea (PNG) has among the highest estimated burdens of cervical cancer globally but currently has no national cervical screening program. Visual inspection of the cervix with acetic acid (VIA) is a low-cost screening strategy endorsed by the World Health Organization that has been adopted in many low-resource settings but not previously evaluated in PNG.

Aim: To evaluate the association between VIA examination findings and high-risk HPV (hrHPV) infection; and the impact of concomitant genital Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis on the interpretation of VIA findings. Read More

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January 2018
7 Reads

Identifying acute cervicitis in an era of less-frequent routine gynecologic examinations.

Authors:
Margaret Allen

JAAPA 2018 Feb;31(2):50-53

Margaret Allen is a former PA program director for the University of Worcester in the United Kingdom, former clinical instructor in the Stanford University primary care associate program, and practiced family medicine at Ravenswood Family Health Center in East Palo Alto, Calif. The author has disclosed no potential conflicts of interest, financial or otherwise.

Acute inflammation of the uterine cervix can lead to serious problems such as pelvic inflammatory disease (PID), endometritis, and complications of pregnancy and childbirth. As intervals for routine gynecologic screening examinations lengthen, cervical infections, especially if asymptomatic, may be missed. Annual wellness examinations and other patient visits outside routine gynecologic cancer screening visits should include brief evaluation with sexual risk assessment and a gynecologic examination if indicated. Read More

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February 2018
2 Reads

Effect of Dialyzable Leukocyte Extract on chronic cervicitis in patients with HPV infection.

J Med Life 2017 Oct-Dec;10(4):237-243

PLaboratory of Molecular Biomedicine I, ENMyH, Instituto Politécnico Nacional, Mexico.

The objective of the study was to assess the clinical, histopathological and immunochemical changes induced by dialyzable leukocyte extract (DLE) treatment in patients with chronic cervicitis associated to HPV infection. Fifty-four female Mexican patients diagnosed with chronic cervicitis, cervical intra-epithelial neoplasia grade 1 (CIN 1) and HPV infection were divided into two groups: patients treated with placebo and patients treated with DLE. Clinical and colposcopy evaluations were performed before and after treatments. Read More

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April 2018
1 Read

Cervical Cancer Induction Enhancement Potential of Chlamydia Trachomatis: A Systematic Review.

Curr Microbiol 2018 Jan 22. Epub 2018 Jan 22.

Laboratory of Microbiology and Molecular Biology, Faculty of Medicine and Pharmacy of Fez (FMPF), Sidi Mohammed Ben Abdellah University (USMBA), Fez, Morocco.

Human papillomavirus (HPV) persistent infection is the necessary but not sufficient cause of cervical cancer. Other co-factors are required to induce cell transformation that will evolve to malignant cervical cancer. These co-factors include physical elements, other sexually transmitted infections, and immune response. Read More

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January 2018
4 Reads

Presence of histopathological premalignant lesions and infection caused by high-risk genotypes of human papillomavirus in patients with suspicious cytological and colposcopy results: A prospective study.

Vojnosanit Pregl 2017 Jan;74(1):24-30

Background/aim: In patients with premalignant cervical lesions, human papillomavirus (HPV) infection, at any moment, may be spontaneously eliminated, or may persist or transform cervical epithelium from a lower to a higher degree. Due to that, it is necessary to wisely select the patients who are at high risk of cancer development. The aim of the study was to establish the interdependence between a suspicious Papanicolaou (Pap) test and colposcopy with the infection caused by high-risk genotypes of human papillomavirus and the presence of premalignant cervical lesions. Read More

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January 2017
6 Reads

Human papillomavirus (HPV) 18 genetic variants and cervical cancer risk in Taizhou area, China.

Gene 2018 Mar 10;647:192-197. Epub 2018 Jan 10.

Laboratory of Gynecologic Oncology, Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, Zhejiang, China. Electronic address:

Human papillomavirus (HPV) type 18 is predominantly associated with the development of cervical adenocarcinomas, whereas data on HPV18 genetic variability in China are limited. HPV18 genetic variants were formed phylogenetic tree, including lineages A, B, and C. We aimed to evaluate the diversity of HPV18 genetic variants by sequencing the entire E6, E7 and L1 genes. Read More

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March 2018
4 Reads

Uterine Prolapse: Should Hysterectomy Specimens be Subjected for Histopathological Examination?

J Midlife Health 2017 Oct-Dec;8(4):179-182

Department of Obstetrics and Gynaecology, Christian Medical College, Ludhiana, Punjab, India.

Context: Uterine prolapse accounts for one of the common gynecological problems in India. The excised uterus is not expected to have any pathological finding other than atrophic endometrium and may be an ulcer because of the prolapse.

Aims: The aim of this study is to assess the hysterectomy specimen for unsuspected pathology. Read More

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January 2018
4 Reads

Human Papilloma Viruses and Their Genotype Distribution in Women with High Socioeconomic Status in Central Anatolia, Turkey: A Pilot Study.

Med Sci Monit 2018 Jan 4;24:58-66. Epub 2018 Jan 4.

Department of Obstetrics and Gynecology, Health Research System In Vitro Fertilization (HRS IVF) Center, Ankara, Turkey.

BACKGROUND In the present study we retrospectively evaluated the results of outpatients who had an HPV analysis, and present objective evidence for the administration of preventive inoculation in our area. MATERIAL AND METHODS We retrospectively reviewed 532 outpatients who visited a single center between 2012 and 2016 and had an HPV infection analysis. The criteria for inclusion of patients with unhealthy cervix in the study were: erosion, chronic cervicitis, healed lacerations, hypertrophied cervix, and abnormal discharges from the cervix. Read More

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January 2018
23 Reads

A proteomic profile of postpartum cervical repair in mice.

J Mol Endocrinol 2018 Jan;60(1):17-28

Department of BiologyAppalachian State University, Boone, North Carolina, USA

A timely and complete uterine cervical tissue repair postpartum is of necessity to prevent obstetrical complications, such as cervicitis, ectropion, hemorrhage, repeated miscarriages or abortions and possibly preterm labor and malignancies. We recently characterized the morphological alterations, as well as changes in angiogenic expression profile in a mice uterine cervix during the immediate postpartum period. Here, we build on this previous study using a proteomic analysis to profile postpartum tissue changes in mice cervix during the same period, the first 48 h of postpartum. Read More

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January 2018
2 Reads

Macrolide and fluoroquinolone resistance in Mycoplasma genitalium in two Swedish counties, 2011-2015.

APMIS 2018 Feb 13;126(2):123-127. Epub 2017 Dec 13.

Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, National Reference Laboratory for Sexually Transmitted Infections, Örebro University, Örebro, Sweden.

Mycoplasma genitalium, causing non-gonococcal non-chlamydial urethritis and associated with cervicitis, has developed antimicrobial resistance (AMR) to both the macrolide azithromycin (first-line treatment) and the fluoroquinolone moxifloxacin (second-line treatment). Our aim was to estimate the prevalence of resistance, based on genetic AMR determinants, to these antimicrobials in the M. genitalium population in two Swedish counties, Örebro and Halland, 2011-2015. Read More

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February 2018
7 Reads

Downregulation of nuclear and cytoplasmic Chibby is associated with advanced cervical cancer.

Oncol Lett 2017 Dec 25;14(6):6632-6644. Epub 2017 Sep 25.

Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan, R.O.C.

Chibby has been identified as a putative tumor suppressor and antagonist to β-catenin, thereby controlling the Wnt signaling pathway. Chibby is typically downregulated in numerous types of cancer and may be associated with tumorigenesis. The present study aimed at clarifying the following: i) Whether Chibby antagonizes β-catenin in cervical cancer; ii) whether Chibby and β-catenin mRNA expression is associated with cancer progression; and iii) whether Chibby and β-catenin expression may be used as a biomarker. Read More

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December 2017
2 Reads

Strain Types Have Diversified Regionally and Globally with Evidence for Recombination across Geographic Divides.

Front Microbiol 2017 13;8:2195. Epub 2017 Nov 13.

UCSF Benioff Children's Hospital Oakland Research Institute, Oakland, CA, United States.

() is the leading cause of bacterial sexually transmitted diseases worldwide. The Multi Locus Sequence Typing (MLST) scheme is effective in differentiating strain types (ST), deciphering transmission patterns and treatment failure, and identifying recombinant strains. Here, we analyzed 323 reference and clinical samples, including 58 samples from Russia, an area that has not previously been represented in typing schemes, to expand our knowledge of the global diversification of STs. Read More

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November 2017
2 Reads

Should we screen for the sexually-transmitted infection Mycoplasma genitalium? Evidence synthesis using a transmission-dynamic model.

Sci Rep 2017 Nov 23;7(1):16162. Epub 2017 Nov 23.

MRC Centre for Outbreak Analysis & Modelling, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, Norfolk Place, London, W2 1PG, UK.

There is increasing concern about Mycoplasma genitalium as a cause of urethritis, cervicitis, pelvic inflammatory disease (PID), infertility and ectopic pregnancy. Commercial nucleic acid amplification tests (NAATs) are becoming available, and their use in screening for M. genitalium has been advocated, but M. Read More

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November 2017
3 Reads

Public health approach to prevent cervical cancer in HIV-infected women in Kenya: Issues to consider in the design of prevention programs.

Gynecol Oncol Rep 2017 Nov 16;22:82-88. Epub 2017 Oct 16.

Department of Internal Medicine & Infectious diseases, University Hospital, Ghent, Belgium.

Women living with HIV in Africa are at increased risk to be co-infected with Human Papilloma Virus (HPV), persistent high risk (HR) HPV infection and bacterial vaginosis (BV), which compounds HPV persistence, thereby increasing the risk for cervical dysplasia. New guidance from WHO in 2014 advocating for a "screen and treat" approach in resource poor settings is becoming a more widely recommended screening tool for cervical cancer prevention programs in such contexts. This review article summarizes the risk factors to be considered when designing a primary and secondary cervical prevention program in a post-vaccination era for HIV-infected women in Kenya. Read More

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November 2017
2 Reads

Irreversible electroporation of the uterine cervix in a rabbit model.

Biomed Microdevices 2017 Nov 14;19(4):103. Epub 2017 Nov 14.

Guangzhou Fuda Cancer Institute, Fuda Cancer Hospital, Jinan University School of Medicine, No. 2, Tangdexi Road, Tianhe District, Guangzhou, Guangdong Province, 510665, China.

The aim of this study was to evaluate the effects of irreversible electroporation (IRE) on the uterine cervix in a rabbit model. IRE ablation was performed in the cervices of 48 New Zealand rabbits, with one ablation lesion in each animal. Gross pathology, transmission electron microscopy, hematoxylin and eosin (H&E), Masson's trichrome (MT) stain, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays were performed at pre-set time points (0 h, 12 h, 1 d, 2 d, 4 d, 7 d, 14 d, and 28 d post-IRE). Read More

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November 2017
4 Reads

National Institute of Allergy and Infectious Diseases workshop report: "Chlamydia vaccines: The way forward".

Vaccine 2017 Oct 31. Epub 2017 Oct 31.

Division of Microbiology and Infectious Diseases, NIAID, Bethesda, MD, USA.

Chlamydia trachomatis (Ct), an intracellular pathogen, is the most common bacterial sexually transmitted infection. In addition to acute cervicitis and urethritis, Ct can lead to serious sequelae of significant public health burden including pelvic inflammatory disease (PID) and infertility. Ct control efforts have not resulted in desired outcomes such as reduced incidence and reinfection, and this highlights the need for the development of an effective Ct vaccine. Read More

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October 2017
3 Reads

p16INK4a Expression in Cervical Lesions Correlates with Histologic Grading - a Tertiary Level Medical Facility Based Retrospective Study

Asian Pac J Cancer Prev 2017 10 26;18(10):2643-2647. Epub 2017 Oct 26.

Pathology Department, Tezpur Medical College, Tezpur, India. Email:

p16INK4a is a tumor-suppressor protein and cyclin-dependent kinase (cdk) inhibitor that blocks cdk4- and cdk6-mediated pRb phosphorylation to inhibit E2F-dependent transcription and cell-cycle progression. Because the E7 protein of high-risk HPVs inactivates pRB, the resulting overexpression of p16INK4a may be a good marker for infection with high risk HPV types. Immunostaining of p16INK4a allows precise identification of even small CIN or cervical cancer lesions in biopsy sections and can help reduce inter-observer variation in the histopathological interpretation of cervical biopsy specimens. Read More

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October 2017
5 Reads

Down-regulation of IFITM1 and its growth inhibitory role in cervical squamous cell carcinoma.

Cancer Cell Int 2017 10;17:88. Epub 2017 Oct 10.

Genecology Research Centre, Centre for Animal Health Innovation, Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Maroochydore, DC, QLD 4558 Australia.

Background: Cervical cancer is a major cause of death in women worldwide. Interferon-induced transmembrane protein 1 (IFITM1) is involved in antivirus defense, cell adhesion, and carcinogenesis in different tissues. However, the role of gene in cervical squamous cell cancer is unclear. Read More

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October 2017
5 Reads

Clinical efficacy of cryotherapy combined with interferon in the treatment of chronic cervicitis complicated with HPV infection.

Pak J Pharm Sci 2017 Jul;30(4(Suppl.)):1505-1508

Department of Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

This paper aims to investigate the clinical curative effect and adverse reactions of cryotherapy combined with interferon in the treatment of chronic cervicitis complicated with HPV infection. 100 cases diagnosed with chronic cervicitis complicated with HPV infection from August 2014 to August 2015 in our hospital were selected and randomly divided into observation group (50 cases) and control group (50 cases). The preoperative and postoperative HPV-DNA changes were observed, and the vaginal discharge, time of decrustation and hemostasis, HPV negative conversion ratio and clinical efficacy were compared, to record the adverse reactions during treatment. Read More

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July 2017
3 Reads

Epidemiology of infertility in China: a population-based study.

BJOG 2018 Mar 28;125(4):432-441. Epub 2017 Dec 28.

Department of Obstetrics and Gynaecology, Reproductive Medical Centre, Peking University Third Hospital, Beijing, China.

Objective: To assess the current prevalence of and risk factors for infertility among couples of reproductive age in China.

Design: Population-based cross-sectional study.

Setting: We approached 25 270 couples in eight provinces/municipalities, of whom 18 571 (response rate 74%) were interviewed. Read More

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March 2018
6 Reads

Prevalence of Sexually Transmitted Infections and Their Risk Factors among Female Sex Workers in Isfahan, Iran: A Cross-Sectional Study.

J Int Assoc Provid AIDS Care 2017 Nov/Dec;16(6):608-614. Epub 2017 Oct 11.

1 Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Objectives: Female sex workers (FSWs) are at high risk of sexually transmitted infections (STIs) and form a core group to facilitate STI spreading. We aimed to estimate the prevalence of STIs among FSWs who attended Female Harm Reduction Center of Isfahan, Iran, and to determine the association between risky behaviors and STIs.

Study Design: In a cross-sectional study, 99 FSWs were recruited and interviewed about demographic characteristics and risky behaviors. Read More

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October 2017
12 Reads

Chlamydia Infection Between Men and Women: A Cross-Sectional Study of Heterosexual Partnerships.

Open Forum Infect Dis 2017 27;4(3):ofx160. Epub 2017 Sep 27.

Melbourne Sexual Health Centre, Alfred Health, Victoria, Australia.

Background: Studies of sexual partnerships can further our understanding of the sexual transmission of chlamydia, which is important for informing public health interventions and clinical management. The aim of this study was to ascertain among heterosexual dyads the proportion concordantly infected with chlamydia and factors associated with infection between partners.

Methods: This study was conducted at the Melbourne Sexual Health Centre between January 2006 and March 2015. Read More

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September 2017
10 Reads

Cyto-colpo-histologic correlation: about an analytical study of 120 colposcopies.

Tunis Med 2016 Oct;94(10):616-620

Problem: Cervical cancer is the second gynecological cancer Tunisian women after breast. This is a sexually transmitted disease including the role of HPV has been proven. Cervical cancer screening is possible due to the accessibility of the cervix with a speculum examination and implementation of cervical smear. Read More

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October 2016
52 Reads

Cervical precancerous changes and selected cervical microbial infections, Kiambu County, Kenya, 2014: a cross sectional study.

BMC Infect Dis 2017 09 25;17(1):647. Epub 2017 Sep 25.

Department of Medical Laboratory Sciences, Kenyatta University, School of Medicine, P. O. Box 43844-00100, Nairobi, Kenya.

Background: Cervical cancer is the predominant cancer among women in Kenya and second most common in women in developing regions. Population-based cytological screening and early treatment reduces morbidity and mortality associated with the cancer. We determined the occurrence of cervical precancerous changes and cervical microbial infections (Trichomonas vaginalis, Candida albicans, Neisseria gonorrhea and Actinomyces) among women attending Family Health Option Kenya (FHOK) clinic in Thika. Read More

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September 2017
1 Read

Clinical and analytical evaluation of the new Aptima Mycoplasma genitalium assay, with data on M. genitalium prevalence and antimicrobial resistance in M. genitalium in Denmark, Norway and Sweden in 2016.

Clin Microbiol Infect 2018 May 18;24(5):533-539. Epub 2017 Sep 18.

Infection Preparedness, Research Unit for Reproductive Tract Microbiology, Statens Serum Institut, Copenhagen, Denmark.

Objectives: Mycoplasma genitalium (MG) causes urethritis and cervicitis, potentially causing reproductive complications. Resistance in MG to first-line (azithromycin) and second-line (moxifloxacin) treatment has increased. We examined the clinical and analytical performance of the new Conformité Européene (CE)/in vitro diagnostics (IVD) Aptima Mycoplasma genitalium assay (CE/IVD AMG; Hologic); the prevalence of MG, Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG); and MG resistance to azithromycin and moxifloxacin in Denmark, Norway and Sweden in 2016. Read More

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May 2018
5 Reads

Detection of Human Papilloma virus by Molecular method from Patients Attending at Colposcopy Clinic of Mymensingh Medical College Hospital, Mymensingh.

Mymensingh Med J 2017 07;26(3):600-607

Dr Habiba Begum, Assistant Professor, Department of Microbiology, Delta Medical College, Mirpur, Dhaka, Bangladesh.

Cervical cancer is the second most common cancer in women worldwide. Human papillomavirus (HPV) is considered as the main cause of invasive cervical cancer and cervical intra-epithelial neoplasia. High risk HPV DNA has been shown to be present in 99. Read More

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July 2017
2 Reads

Comparative Study of Cytology and Histopathology of Cervical Lesion in VIA Positive Patients and Its Correlation with High Risk Human Papilloma Virus.

Mymensingh Med J 2017 07;26(3):505-513

Dr Nazma Parvin Ansari, Resident of Pathology, Mymensingh Medical College, Mymensingh, Bangladesh.

Cervical cancer is the second most frequent type of cancer and leading cause of mortality among women worldwide. The present study was undertaken to assess precancerous and cancerous cervical lesion by cytology as well as HPV DNA identification and their comparison with histopathology in VIA positive cases. This descriptive, cross-sectional type of observational study was carried out in the Department of Pathology, Mymensingh Medical College in collaboration with the Department of Gynecology and Obstetrics, Mymensingh Medical College Hospital and Department of Microbiology and Hygiene in Bangladesh Agriculture University for HPV DNA detection from July 2012 to June 2013. Read More

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July 2017
7 Reads

Distribution of Chlamydia Trachomatis Genotypes in Infective Diseases of the Female Lower Genital Tract.

Med Sci Monit 2017 Sep 17;23:4477-4481. Epub 2017 Sep 17.

Department of Gynecology, The People's Hospital of Liuzhou, Liuzhou, Guangxi, China (mainland).

The purpose of this study was to investigate the distribution of Chlamydia trachomatis (CT) genotypes in infective diseases of the female lower genital tract, especially in cervical diseases. This study included 128 CT-positive women. DNA was extracted from cervical swabs. Read More

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September 2017
6 Reads

Tuberculous cervicitis: A brief report with cytohistological correlation and differential diagnosis.

Diagn Cytopathol 2017 Dec 10;45(12):1153-1155. Epub 2017 Sep 10.

Faculty of Pharmacy, University of Salamanca, Salamanca 37007, Spain.

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December 2017
6 Reads

Regression of uterine cervical diffuse large B-cell lymphoma transformed from mucosa-associated lymphoid tissue lymphoma subsequent to Chlamydia trachomatis eradication.

Rinsho Ketsueki 2017 ;58(8):912-916

Department of Pathology, Kurume University School of Medicine.

A 37-year-old-woman was referred to our center after her uterine cervix health screening presented abnormal findings. We performed a biopsy of the uterine cervix to examine for cervical dysplasia, and diagnosed a diffuse large B-cell lymphoma transformed from mucosa-associated lymphoid tissue (MALT) lymphoma of the cervix. The patient presented with concurrent chlamydial cervicitis and received eradication therapy for Chlamydia trachomatis. Read More

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December 2017
5 Reads

Prevalence and significance of Mycoplasma genitalium in women living with HIV in Denmark.

BMC Res Notes 2017 Sep 7;10(1):468. Epub 2017 Sep 7.

Statens Serum Institut, Copenhagen, Denmark.

Objective: Mycoplasma genitalium (M. genitalium) is a sexually transmitted pathogen associated with urethritis, cervicitis, and pelvic inflammatory disease. Previous studies have shown a strong association between M. Read More

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September 2017
4 Reads

Nanomechanical Characteristics of Cervical Cancer and Cervical Intraepithelial Neoplasia Revealed by Atomic Force Microscopy.

Med Sci Monit 2017 Aug 31;23:4205-4213. Epub 2017 Aug 31.

Department of Obstetrics and Gynecology, Peking University 3rd Hospital, Beijing, China (mainland).

BACKGROUND Understanding the biological features and developmental progress of cervical cancer is crucial for disease prevention. This study aimed to determine the nanomechanical signatures of cervical samples, ranging from cervicitis to cervical carcinomas, and to investigate the underlying mechanisms. MATERIAL AND METHODS Forty-five cervical biopsies at various pathological stages were subjected to atomic force microscopy (AFM) measurements. Read More

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August 2017
12 Reads