3,384 results match your criteria Cervicitis


Molecular Diagnosis of Human Papilloma Virus by PCR.

Mymensingh Med J 2019 Jan;28(1):175-181

Dr Faijun Nahar, Assistant Professor, Department of Microbiology, President Abdul Hamid Medical College, Kishoreganj, Bangladesh.

Cervical cancer is a major world health problem and the fourth most leading cause of death in women around the world. High risk HPV DNA has been shown to be present in 99.7% of cervical cancers worldwide. Read More

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January 2019
7 Reads

Occurrence of Mycoplasma genitalium in the peritoneal fluid of fertile and infertile women with detailed analysis among infertile women.

Microb Pathog 2019 Feb 5;129:183-186. Epub 2019 Feb 5.

Department of Zoology, University of Rajasthan, Jaipur, Rajasthan, India. Electronic address:

Objective: To determine the frequency of occurrence of Mycoplasma genitalium infection in the peritoneal fluid of infertile women as compared to fertile women.

Materials And Methods: We have selected 162 infertile women aged 22-40 years as study subject and 162 women posted for elective caesarean section, were taken as control. Peritoneal fluid of the infertile women and control samples was obtained by suction during diagnostic laparoscopy and M. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.02.006DOI Listing
February 2019
1 Read

Chinese Herbal Formula Feilin Vaginal Gel Prevents the Cervicitis in Mouse Model.

Evid Based Complement Alternat Med 2019 10;2019:4168126. Epub 2019 Jan 10.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Cervicitis is a common sexually transmitted disease. In recent years, the abuse of antibiotic in the treatment of cervicitis results in the emergence of antibiotic-resistant bacteria; alternative strategies are needed to be developed. In this research, we investigated the effects of Feilin Vaginal Gel (FVG), a Chinese herbal formula, on the treatment of cervicitis. Read More

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http://dx.doi.org/10.1155/2019/4168126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348856PMC
January 2019
2 Reads

Current status of Neisseria gonorrhoeae cervicitis in pregnant women in Japan.

PLoS One 2019 7;14(2):e0211595. Epub 2019 Feb 7.

Japanese Foundation for Sexual Health Medicine, Tokyo, JAPAN.

We evaluated the current prevalence of gonococcal cervicitis among pregnant women in institutes that either do or do not routinely screen for gonococcal infection in Japan. We requested 2,330 obstetrical facilities to provide information on Neisseria gonorrhoeae cervicitis in pregnant women. A total of 1,876 (80. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211595PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366733PMC
February 2019

Comparison of Chlorquinaldol-Promestriene Vaginal Tablets and Opin Suppositories Effect on Inflammatory Factors and Immune Function in Chronic HPV Cervicitis.

J Coll Physicians Surg Pak 2019 Feb;29(2):115-118

Department of Gynaecology and Obstetrics, People's Hospital of Zhouzhi County, Shaanxi, 710400, China.

Objective: To compare the effects of chlorquinaldol-promestriene vaginal tablets and opin suppositories on serum inflammatory factors and immune function in patients with chronic cervicitis complicated with HPV infection.

Study Design: An experimental study.

Place And Duration Of Study: Department of Gynaecology and Obstetrics, People's Hospital of Zhouzhi County, Shaanxi, China, from January 2016 to June 2017. Read More

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https://www.jcpsp.pk/archive/2019/Feb2019/05.pdf
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http://dx.doi.org/10.29271/jcpsp.2019.02.115DOI Listing
February 2019
2 Reads

Suppression of miR-93-5p inhibits high-risk HPV-positive cervical cancer progression via targeting of BTG3.

Hum Cell 2019 Jan 28. Epub 2019 Jan 28.

Department of Gynecology, Second Hospital of Hebei Medical University, No.215, HePing West Road, Shijiazhuang, 050000, Hebei, China.

This study explores the role of miR-93-5p in high-risk HPV-positive (HR-HPV) cervical cancer by targeting of BTG3. Cervical tissues were collected from 332 patients with conditions of chronic cervicitis (n = 42), low-grade cervical intraepithelial neoplasia (CIN I, n = 51), CIN II (n = 49), CIN III (n = 43), cervical cancer (n = 90), and normal cervical tissues (n = 57). HR-HPV DNA was detected by Hybrid Capture 2, and the expressions of miR-93-5p and BTG3 were determined by qRT-PCR and Western blot. Read More

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http://dx.doi.org/10.1007/s13577-018-00225-1DOI Listing
January 2019
1 Read

Antibiotics for treating urogenital Chlamydia trachomatis infection in men and non-pregnant women.

Cochrane Database Syst Rev 2019 Jan 25;1:CD010871. Epub 2019 Jan 25.

Clinical Research Institute, Faculty of Medicine, Universidad Nacional de Colombia, Bogota, Colombia.

Background: The genital infection caused by Chlamydia trachomatis (CT) is a common sexually transmitted infection (STI) globally. The infection is mainly asymptomatic in women, thus it can produce infertility and chronic pelvic pain. In men infection is mainly symptomatic, but can evolve to prostatitis. Read More

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http://dx.doi.org/10.1002/14651858.CD010871.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353232PMC
January 2019
3 Reads

Utility of P16/INK4a and Ki-67 in Preneoplasticand Neoplastic Lesions of Cervix.

Iran J Pathol 2018 12;13(3):308-316. Epub 2018 Sep 12.

Dept. of Pathology, Pt. B D Sharma, PGIMS, Rohtak, Haryana, India.

Background And Objective: The currentstudy aimed at investigating the histomorphological spectrum of cervical intraepithelial and invasive lesions assessing the diagnostic significance of P16/INK4a and Ki-67 in such lesions, andcorrelatingP16/ INK4a and Ki-67 immunoexpression with histologic type and grade.

Methods: A total of 60 cases were selectedcomprising 10 cases withchronic cervicitis, 29 cases withcervical intraepithelial neoplasia(CIN), and 21 cases withsquamous cell carcinoma. These cases were evaluated morphologically and immunohistochemically with P16 and Ki-67. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322520PMC
September 2018
5 Reads

Cervicitis: Etiology, diagnosis and treatment.

Enferm Infecc Microbiol Clin 2019 Jan 7. Epub 2019 Jan 7.

Unidad de Enfermedades Infecciosas, Hospital General Universitario de Elche, Universidad Miguel Hernández, Elche, Alicante, España.

Cervicitis is the inflammation of the cervix. It is usually caused by an infectious agent, usually sexually transmitted. Cervicitis is frequently asymptomatic and silent infection can cause complications of the upper genital tract. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0213005X183040
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http://dx.doi.org/10.1016/j.eimc.2018.12.004DOI Listing
January 2019
6 Reads

TLR3 deficiency exacerbates the loss of epithelial barrier function during genital tract Chlamydia muridarum infection.

PLoS One 2019 9;14(1):e0207422. Epub 2019 Jan 9.

Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.

Problem: Chlamydia trachomatis infections are often associated with acute syndromes including cervicitis, urethritis, and endometritis, which can lead to chronic sequelae such as pelvic inflammatory disease (PID), chronic pelvic pain, ectopic pregnancy, and tubal infertility. As epithelial cells are the primary cell type productively infected during genital tract Chlamydia infections, we investigated whether Chlamydia has any impact on the integrity of the host epithelial barrier as a possible mechanism to facilitate the dissemination of infection, and examined whether TLR3 function modulates its impact.

Method Of Study: We used wild-type and TLR3-deficient murine oviduct epithelial (OE) cells to ascertain whether C. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207422PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326510PMC
January 2019
8 Reads

Use of mesothelin as a tumor-associated antigen in cervical squamous cell carcinoma.

Gene 2019 Mar 21;690:30-37. Epub 2018 Dec 21.

Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Dongcheng District, Beijing 100006, China. Electronic address:

Aim: To explore the feasibility of using mesothelin (MESO) as a tumor-associated antigen (TAA) in cervical squamous cell carcinoma and its function in the development of cervical cancer.

Methods: We collected eight cervical tissue samples of squamous cell carcinoma as the test group and eight samples of cervicitis as the control group from patients who underwent a hysterectomy because of a diagnosis of myoma. Then we used western blotting to screen for a potential TAA in cervical squamous cell carcinoma samples. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781119183128
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http://dx.doi.org/10.1016/j.gene.2018.12.029DOI Listing
March 2019
8 Reads

A Clinical Conundrum: Chronic Cervicitis.

J Pediatr Adolesc Gynecol 2018 Dec 21. Epub 2018 Dec 21.

Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma. Electronic address:

Background: Cervicitis is most commonly caused by sexually transmitted infections. "Normal vaginal flora" are rarely responsible for inflammation of the cervix.

Case: We describe a 22-year-old female patient with chronic cervicitis who had negative test results for bacterial and viral pathogens most commonly responsible for cervicitis. Read More

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http://dx.doi.org/10.1016/j.jpag.2018.12.004DOI Listing
December 2018
2 Reads

[The role of HPV E6/E7 mRNA combined with P16/ki67 immunocytochemistry in the diagnosis of atypical squamous cells of undetermined significance(ASCUS)].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2018 Oct;34(10):937-941

Department of Pathology, Zhongshan BOAI Hospital Affiliated to Southern Medical University, Zhongshan 528400, China.

Objective To investigate the diagnostic value of human papillomavirus (HPV) E6/E7 mRNA combined with P16/antigen KI-67(ki67) immunocytochemical double staining in the atypical squamous cells of undetermined significance (ASCUS). Methods A total of 272 patients were selected and the results of HPV E6/E7 and P16/ki67 immunocytochemical double staining in the remaining cytological specimens were retrospectively analyzed. HPV E6/E7 gene was detected by HPV E6/E7 gene detection kit and Panther molecular diagnostic instrument. Read More

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October 2018
1 Read

Correlative analysis of the expression of IL-10 and Ki-67 in human cervical cancer and cervical intraepithelial neoplasias and human papillomavirus infection.

Oncol Lett 2018 Dec 28;16(6):7189-7194. Epub 2018 Sep 28.

Department of Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200127, P.R. China.

This study investigated the expression of IL-10 and Ki-67 in human cervical cancer and cervical intraepithelial neoplasia (CIN) and the correlation with human papillomavirus infection. A total of 110 patients with cervical lesions undergoing surgical treatment in Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine from 2016 to 2017 were selected. Those patients included 36 cases of cervical cancer and 74 cases of CIN. Read More

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http://dx.doi.org/10.3892/ol.2018.9520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256322PMC
December 2018

Prevalence of human papillomavirus among Wenzhou women diagnosed with cervical intraepithelial neoplasia and cervical cancer.

Infect Agent Cancer 2018 26;13:37. Epub 2018 Nov 26.

Department of Pathology, Wenzhou People's Hospital, The third Clinical Institute Affiliated to Wenzhou Medical University, 299 Guan Rd. Ouhai district, Wenzhou, Zhejiang, China.

Background: Human papillomavirus (HPV) is associated with an increased risk of cervical cancer. Using a vaccine to prevent HPV infections could be a cost-effective strategy to decrease the incidence of cervical cancer. Learning about the characteristics of CIN patients with HPV infection in Wenzhou is a key step in guiding the use of HPV vaccines and screening for cervical cancer. Read More

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http://dx.doi.org/10.1186/s13027-018-0211-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260560PMC
November 2018
1 Read

[Paraffin section thickness in immunohistochemical detection of p16 expression in cervical tissue samples].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2018 Feb;47(4):362-366

Department of Pathology, Zhongshan Boai Hospital Affiliated to Southern Medical University, Zhongshan 528400, Guangdong Province, China.

Objective: To investigate paraffin section thickness in immunohistochemical detection of p16 expression in cervical tissue samples.

Methods: p16 immunohistochemical staining was performed in 150 cases of chronic cervicitis, 126 cases of low-grade squamous intraepithelial lesions(LSIL), 96 cases of high-grade squamous intraepithelial lesions (HSIL) and 78 cases of cervical cancer from January 2014 to March 2018 in Zhongshan Boai Hospital. The results of p16 protein expression in paraffin sections with thickness of 2, 3, 4, 5 and 6 μm were compared using Logistic regression analysis. Read More

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February 2018
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[Value of combined detection of claudin 4 and high-risk human papilloma virus in high-grade squamous intraepithelial lesion and cervix squamous cell carcinoma].

Authors:
Chenhong Di Fan Jin

Zhejiang Da Xue Xue Bao Yi Xue Ban 2018 Feb;47(4):344-350

Department of Reproductive Genetics, Women's Hospital, Zhejiang University School of Medicine, Key Laboratory of Reproductive Genetics, Ministry of Education, Hangzhou 310006, China.

Objective: To investigate the expression of claudin 4 (CLDN4) in cervical tissues from patients with different cervical lesions, and to explore the value of combined detection of CLDN4 and high risk human papilloma virus (HR-HPV).

Methods: The cervical tissue specimens of low-grade squamous intraepithelial lesion (LSIL, =30), high-grade squamous intraepithelial lesion (HSIL, =30), squamous cell carcinoma (SCC, =30) as well as chronic cervicitis (control, =30) were collected from the Sir Run Run Shaw Hospital of Zhejiang University during June 2015 and December 2016. The expression of CLDN4 protein in tissue specimens was detected by immunohistochemistry, HR-HPV was detected by real-time quantitative PCR, and the cervical exfoliated cells were examined by thinprep cytologic test (TCT). Read More

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February 2018
1 Read

Human papillomaviruses 16 and 58 are distributed widely among women living in Shanghai, China, with high-grade, squamous intraepithelial lesions.

Epidemiol Infect 2018 Nov 13:1-6. Epub 2018 Nov 13.

Department of Obstetrics and Gynecology,Minhang Hospital, Fudan University,170 Xinsong Road, Minhang District, Shanghai 201199,P.R. China.

The distribution of human papillomaviruses (HPVs) must be understood for the control and prevention of cervical cancer. Community-based Papanicolaou and HPV DNA tests were performed on 41 578 women. The prevalences of HPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68 were assessed. Read More

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http://dx.doi.org/10.1017/S0950268818003011DOI Listing
November 2018
8 Reads

Analysis of cervical human papillomavirus infection in 2300 women in Urumqi, China.

Medicine (Baltimore) 2018 Nov;97(45):e13206

Department of Obstetrics and Gynecology, Dongfang Hospital of Tongji University, Shanghai, China.

This study is to investigate the cervical human papillomavirus (HPV) infection rate in women of Urumqi, China.The epidemiological questionnaire survey was used to study 2300 women in Urumqi with a prospective research method. The second-generation hybrid capture assay, cervical liquid-based cytology test, colposcopy, and cervical biopsy were used to screen CC. Read More

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http://dx.doi.org/10.1097/MD.0000000000013206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250538PMC
November 2018
2 Reads

Human papillomavirus DNA, HPV L1 capsid protein and p16 protein as markers to predict cervical lesion progression.

Arch Gynecol Obstet 2019 Jan 2;299(1):141-149. Epub 2018 Nov 2.

Department of Gynaecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 201240, China.

Objectives: Cervical cancer is the most common malignant tumors in women leading to serious morbidity and mortality worldwide, especially among developing countries. A main cause of the disease is the high-risk human papillomavirus (HR-HPV) infection. HSIL usually progress to cervical cancer, and low-grade lesions, including LSIL and ASCUS, mostly turn to normal or benign lesions, but there are still a small number of patients who will progress to HSIL. Read More

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http://link.springer.com/10.1007/s00404-018-4931-1
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http://dx.doi.org/10.1007/s00404-018-4931-1DOI Listing
January 2019
9 Reads

[Relationship of Toll Like Receptors Expression and HPV16 Infection in Cervical Squamous Cell Cancer].

Sichuan Da Xue Xue Bao Yi Xue Ban 2018 Jul;49(4):649-651

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China.

Objective: To analyze the relationship between Toll like receptors () mRNA expression levels and HPV16 infection in cervical squamous cell cancer (SCC).

Methods: Expression levels of mRNA and HPV16 in tissue samples collected from cervical squamous carcinoma and cervicitis were detected, and the relationship of mRNA expression and HPV infection was analyzed in two different disease groups.

Results: Expressions of mRNA were not related to HPV16 infection in cervical squamous cell cancer. Read More

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July 2018
9 Reads

[Current diagnosis and treatment of sexually transmitted infections].

Urologe A 2018 Dec;57(12):1436-1444

Klinik für Urologie, Kinderurologie und Andrologie, Justus-Liebig-Universität Gießen, Rudolf-Buchheim-Str. 7, 35392, Gießen, Deutschland.

Background: In recent years, there has been an increasing incidence of sexually transmitted infections (STI), which in turn play a major role in urological clinical routine.

Objectives: Which STIs are relevant in urological clinical routine? What kind of recommendations for diagnosis and treatment exist?

Materials And Methods: Review of evidence-based recommendations from the literature, current guidelines of the European Association of Urology and the Robert-Koch-Institute.

Results: STIs can be differentiated into those that cause genital, anal, perianal or oral ulcers from STIs that cause urethritis, cervicitis, or urethral or vaginal discharge. Read More

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http://dx.doi.org/10.1007/s00120-018-0803-3DOI Listing
December 2018
2 Reads

Mycoplasma genitalium Infections in Women Attending a Sexually Transmitted Disease Clinic in New Orleans.

Clin Infect Dis 2018 Oct 23. Epub 2018 Oct 23.

Department of Medicine, Section of Infectious Diseases, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, USA.

Background: Several studies have reported statistically significant associations of Mycoplasma genitalium with cervicitis, urethritis, or vaginal discharge, although non-significant associations have also been reported. This study examined the associations of M. genitalium with selected sexually transmitted infections (STIs), demographic, behavioral, and clinical factors among women attending a sexually transmitted disease (STD) clinic in New Orleans. Read More

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http://dx.doi.org/10.1093/cid/ciy922DOI Listing
October 2018
4 Reads

Analysis of gene mutation associated with tyrosine kinase inhibitor sensitivity of epidermal growth factor receptor in cervical cancer patients.

Eur Rev Med Pharmacol Sci 2018 Oct;22(19):6280-6287

Department of Obstetrics and Gynecology, The First Clinical Medicine College of Yangtze University, Jingzhou, Hubei, China.

Objective: Cervical cancer is frequent in females. Epidermal growth factor receptor has a prominent expression in certain malignant tumors. This study aims to observe the expressional profile of epidermal growth factor receptor (EGFR) in cervical cancer patients, and mutation of EGFR gene related with its sensitivity towards tyrosine kinase inhibitor. Read More

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http://dx.doi.org/10.26355/eurrev_201810_16036DOI Listing
October 2018
3 Reads

Prevalence characteristics of single and multiple HPV infections in women with cervical cancer and precancerous lesions in Beijing, China.

J Med Virol 2019 Mar 13;91(3):473-481. Epub 2018 Nov 13.

Department of Gynecology and Obstetrics, People's Liberation Army (PLA) Medical School, Chinese PLA General Hospital, Beijing, China.

We assessed the prevalence characteristics of single and multiple high-risk human papillomavirus (HR-HPV) infections. A total of 1783 women who underwent colposcopy and cervical biopsy for abnormal ThinPrep Cytology Test and/or HR-HPV subtype genotyping results were enrolled in the study. Among the participants, 770 were diagnosed with cervicitis, 395 with cervical intraepithelial neoplasia grade 1 (CIN1), 542 with CIN2-3, and 76 with squamous cell carcinoma (SCC), with HR-HPV infection rates of 75. Read More

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http://dx.doi.org/10.1002/jmv.25331DOI Listing
March 2019
4 Reads

Clinical Value of Human Papillomavirus E6/E7 mRNA Detection in Screening for Cervical Cancer in Women Positive for Human Papillomavirus DNA or.

Clin Lab 2018 Sep;64(9):1363-1371

Background: The detection of human papillomavirus (HPV) E6/E7 mRNA indicates a risk of further deterioration in cervical lesions. We explored the clinical value of HPV E6/E7 mRNA detection in cervical cancer screening in women positive for HPV or with abnormal thin-prep cytology test (TCT) results in the Xinjiang region of China.

Methods: A total of 6,800 women were screened in our hospital for cervical cancer by both TCT and HPV DNA testing from August 2013 to June 2015. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180138DOI Listing
September 2018
14 Reads

The Additive Value of Pelvic Examinations to History in Predicting Sexually Transmitted Infections for Young Female Patients With Suspected Cervicitis or Pelvic Inflammatory Disease.

Ann Emerg Med 2018 Dec 2;72(6):703-712.e1. Epub 2018 Jul 2.

Department of Emergency Medicine, Newark Beth Israel Medical Center, Newark, NJ; Children's Hospital of New Jersey, Newark, NJ. Electronic address:

Study Objective: We evaluate the additive value of pelvic examinations in predicting sexually transmitted infection for young female patients with suspected cervicitis or pelvic inflammatory disease in a pediatric emergency department (ED).

Methods: This was a prospective observational study of female patients aged 14 to 20 years who presented to an urban academic pediatric ED with a complaint of vaginal discharge or lower abdominal pain. Enrolled patients provided a urine sample for chlamydia, gonorrhea, and trichomonas testing, which served as the criterion standard for diagnosis. Read More

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http://dx.doi.org/10.1016/j.annemergmed.2018.05.004DOI Listing
December 2018
6 Reads

Efficacy and safety of combined high-dose interferon and red light therapy for the treatment of human papillomavirus and associated vaginitis and cervicitis: A prospective and randomized clinical study.

Medicine (Baltimore) 2018 Sep;97(37):e12398

Department of Dermatovenereology, Ningxia Yangguang Hospital, Yinchuan, China.

Background: We evaluated the efficacy and safety of combined high-dose interferon (IFN) and red light therapy for the treatment of subclinical and latent human papillomavirus (HPV) infections.

Methods: Ninety women diagnosed with subclinical or latent HPV infection were randomized to receive topical application of low-dose recombinant IFNα-2b (1 million IU), high-dose IFNα-2b (9 million IU), or a combination of high-dose IFNα-2b and red light therapy on the cervix and vagina. All patients received treatment once daily for 4 weeks. Read More

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http://dx.doi.org/10.1097/MD.0000000000012398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156011PMC
September 2018
4 Reads

The Role of Polymorphonuclear Leukocyte Counts from Urethra, Cervix, and Vaginal Wet Mount in Diagnosis of Nongonococcal Lower Genital Tract Infection.

Infect Dis Obstet Gynecol 2018 26;2018:8236575. Epub 2018 Jul 26.

Oslo University Hospital, Department of Venereology, The Olafia Clinic, Norwegian National Advisory Unit on Sexually Transmitted Infections, Oslo, Norway.

Objective: The aim of this study was to evaluate whether the polymorphonuclear leukocyte (PMNL) inflammatory response in women with nongonococcal lower genital tract infection (LGTI) can be used to optimize criteria for syndromic treatment.

Methods: A cross-sectional study of 375 women attending the STI clinic in Oslo. Urethral, cervical, and vaginal specimens underwent microscopy for PMNLs. Read More

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http://dx.doi.org/10.1155/2018/8236575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083538PMC
January 2019
7 Reads

PP2A Inhibits Cervical Cancer Cell Migration by Dephosphorylation of p-JNK, p-p38 and the p-ERK/MAPK Signaling Pathway.

Curr Med Sci 2018 Feb 15;38(1):115-123. Epub 2018 Mar 15.

Department of Clinical Laboratory, Wuhan, 430060, China.

Protein phosphatase 2A (PP2A) was reported to play an important role in cancer development; however, the relationship between PP2A and cervical cancer development has yet to be fully understood. The present study aimed to explore the role of PP2A in the development of cervical cancer. Serum levels of PP2A were detected by ELISA in 23 patients with cervical cancer and 30 patients with benign cervical lesions. Read More

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http://link.springer.com/10.1007/s11596-018-1854-9
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http://dx.doi.org/10.1007/s11596-018-1854-9DOI Listing
February 2018
3 Reads

2018 European (IUSTI/WHO) International Union against sexually transmitted infections (IUSTI) World Health Organisation (WHO) guideline on the management of vaginal discharge.

Int J STD AIDS 2018 Nov 27;29(13):1258-1272. Epub 2018 Jul 27.

5 Research Unit for Reproductive Microbiology, Statens Serum Institut, Copenhagen, Denmark.

Four common pathological conditions are associated with vaginal discharge: bacterial vaginosis, aerobic vaginitis, candidosis, and the sexually transmitted infection, trichomoniasis. Chlamydial or gonococcal cervical infection may result in vaginal discharge. Vaginal discharge may be caused by a range of other physiological and pathological conditions including atrophic vaginitis, desquamative inflammatory vaginitis, cervicitis, and mucoid ectopy. Read More

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http://dx.doi.org/10.1177/0956462418785451DOI Listing
November 2018
35 Reads

B lymphocytes can be activated to act as antigen presenting cells to promote anti-tumor responses.

PLoS One 2018 5;13(7):e0199034. Epub 2018 Jul 5.

Department of Immunology, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.

Immune evasion by tumors includes several different mechanisms, including the inefficiency of antigen presenting cells (APCs) to trigger anti-tumor T cell responses. B lymphocytes may display a pro-tumoral role but can also be modulated to function as antigen presenting cells to T lymphocytes, capable of triggering anti-cancer immune responses. While dendritic cells, DCs, are the best APC population to activate naive T cells, DCs or their precursors, monocytes, are frequently modulated by tumors, displaying a tolerogenic phenotype in cancer patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199034PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033398PMC
December 2018
13 Reads

Ureaplasma urealyticum: the Role as a Pathogen in Women's Health, a Systematic Review.

Curr Infect Dis Rep 2018 Jun 29;20(9):33. Epub 2018 Jun 29.

Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Hebrew University, Jerusalem, Israel.

Purpose Of Review: To evaluate the role of Ureaplasma urealyticum as a genital pathogen in women's health. Three aspects were analyzed: (1) preterm delivery (PTD); (2) female infertility; and (3) lower genital tract pathology including pelvic inflammatory disease (PID), cervicitis, and genital discomfort (discharge, burning).

Recent Findings: A systematic review was performed. Read More

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http://dx.doi.org/10.1007/s11908-018-0640-yDOI Listing
June 2018
38 Reads

Transcriptome Analysis of Neisseria gonorrhoeae during Natural Infection Reveals Differential Expression of Antibiotic Resistance Determinants between Men and Women.

mSphere 2018 08 27;3(3). Epub 2018 Jun 27.

Department of Immunology, Tufts University School of Medicine, Boston, Massachusetts, USA

is a bacterial pathogen responsible for the sexually transmitted infection gonorrhea. Emergence of antimicrobial resistance (AMR) of worldwide has resulted in limited therapeutic choices for this infection. Men who seek treatment often have symptomatic urethritis; in contrast, gonococcal cervicitis in women is usually minimally symptomatic, but may progress to pelvic inflammatory disease. Read More

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http://dx.doi.org/10.1128/mSphereDirect.00312-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021601PMC
August 2018
23 Reads
1 Citation

Sipi soup inhibits cancer‑associated fibroblast activation and the inflammatory process by downregulating long non‑coding RNA HIPK1‑AS.

Mol Med Rep 2018 Aug 6;18(2):1361-1368. Epub 2018 Jun 6.

Department of Acupuncture and Moxibustion, Longyan First Hospital, Longyan, Fujian 364000, P.R. China.

Sipi soup (SPS), the aqueous extract derived from the root bark of Sophora japonical L, Salix babylonica L., Morus alba L., as well as Amygdalus davidiana (Carr. Read More

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http://dx.doi.org/10.3892/mmr.2018.9144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072218PMC
August 2018
3 Reads

A prospective pilot evaluation of vaginal and urine self-sampling for the Roche cobas 4800 HPV test for cervical cancer screening.

Sci Rep 2018 Jun 13;8(1):9015. Epub 2018 Jun 13.

National Cancer Control Institute, National Cancer Center, Goyang, 10408, Republic of Korea.

This pilot study sought to evaluate the feasibility of utilizing vaginal self-swabs and urine samples for HPV-based cervical cancer screening in 700 women who had undergone conventional Pap smear screening via the national cervical cancer program in Korea. The cobas 4800 HPV test was utilized to detect HPV in the self-samples. Pap smear results revealed three cases of atypical squamous cells of undetermined significance, 649 cases of negative for an intraepithelial lesion or malignancy, and 48 non-specific inflammatory findings. Read More

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http://dx.doi.org/10.1038/s41598-018-27390-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998027PMC
June 2018
4 Reads
5.080 Impact Factor

Applications of genomics to slow the spread of multidrug-resistant Neisseria gonorrhoeae.

Ann N Y Acad Sci 2019 Jan 6;1435(1):93-109. Epub 2018 Jun 6.

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

Infections with Neisseria gonorrhoeae, a sexually transmitted pathogen that causes urethritis, cervicitis, and more severe complications, are increasing. Gonorrhea is typically treated with antibiotics; however, N. gonorrhoeae has rapidly acquired resistance to many antibiotic classes, and lineages with reduced susceptibility to the currently recommended therapies are emerging worldwide. Read More

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http://dx.doi.org/10.1111/nyas.13871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281808PMC
January 2019
5 Reads

Outcomes of Resistance-guided Sequential Treatment of Mycoplasma genitalium Infections: A Prospective Evaluation.

Clin Infect Dis 2019 Feb;68(4):554-560

Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne.

Background: Rising macrolide and quinolone resistance in Mycoplasma genitalium necessitate new treatment approaches. We evaluated outcomes of sequential antimicrobial therapy for M. genitalium guided by a macrolide-resistance assay. Read More

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http://dx.doi.org/10.1093/cid/ciy477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355821PMC
February 2019
6 Reads

BLT1-mediated O-GlcNAcylation is required for NOX2-dependent migration, exocytotic degranulation and IL-8 release of human mast cell induced by Trichomonas vaginalis-secreted LTB.

Microbes Infect 2018 Jun - Jul;20(6):376-384. Epub 2018 May 31.

Department of Environmental Medical Biology, Institute of Tropical Medicine, South Korea; Yonsei University College of Medicine, Seoul 120-752, South Korea. Electronic address:

Trichomonas vaginalis is a sexually-transmitted protozoan parasite that causes vaginitis and cervicitis. Although mast cell activation is important for provoking tissue inflammation during infection with parasites, information regarding the signaling mechanisms in mast cell activation and T. vaginalis infection is limited. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12864579183011
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http://dx.doi.org/10.1016/j.micinf.2018.05.005DOI Listing
May 2018
4 Reads

Expression of AMHR2 and C-KIT in cervical lesions in Uyghur Women of Xinjiang, China.

Medicine (Baltimore) 2018 Jun;97(22):e10793

Department of Histology and Embryology.

Background: Cervical cancer is one of the most common malignant tumors in women. Anti-Müllerian hormone receptor 2 (AMHR2) and C-Kit were two members of protein kinase which were reported increased in some cancers like ovarian carcinoma and breast cancer. The present study aimed to assess the expression of AMHR2 and c-Kit in cervical cancer of different differentiated degrees as well as in cervicitis sections. Read More

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http://dx.doi.org/10.1097/MD.0000000000010793DOI Listing
June 2018
15 Reads

Common Sexually Transmitted Infections in Women.

Nurs Clin North Am 2018 06;53(2):189-202

Department of Family, Community, and Health Systems, University of Alabama at Birmingham School of Nursing, 1701 University Boulevard, Birmingham, AL 35294-1210, USA.

The spread of sexually transmitted infections (STIs) remains a significant public health issue in the United States. Social, economic, and behavioral implications affecting the spread of STIs have been identified. The most important social factor in the United States is the stigma associated with discussing sex and STI screening. Read More

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http://dx.doi.org/10.1016/j.cnur.2018.01.013DOI Listing
June 2018
26 Reads

An integrative investigation of the therapeutic mechanism of Ainsliaea fragrans Champ. in cervicitis using liquid chromatography tandem mass spectrometry based on a rat plasma metabolomics strategy.

J Pharm Biomed Anal 2018 Jul 27;156:221-231. Epub 2018 Apr 27.

Jiangxi University of Traditional Chinese Medicine, No. 818 Yunwan Road, Nanchang 330002, PR China; State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, No. 56 Yangming Road, Nanchang 330006, PR China. Electronic address:

Cervicitis is an extremely common gynecological disease and can be induced by diverse factors such as Neisseria gonorrhoeae, Chlamydia trachomatis, and Mycoplasma genitalium infections. Long-term unhealed cervicitis may lead to a series of diseases including endometritis, salpingitis, pelvic inflammatory disease, and chorioamnionitis. However, the pathogenesis of cervicitis remains unknown. Read More

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http://dx.doi.org/10.1016/j.jpba.2018.04.048DOI Listing
July 2018
19 Reads

Comparative Metabolomics Analysis of Cervicitis in Human Patients and a Phenol Mucilage-Induced Rat Model Using Liquid Chromatography Tandem Mass Spectrometry.

Front Pharmacol 2018 4;9:282. Epub 2018 Apr 4.

Jiangxi University of Traditional Chinese Medicine, Nanchang, China.

Cervicitis is an exceedingly common gynecological disorder that puts women at high risk of sexually transmitted infections and induces a series of reproductive system diseases. This condition also has a significant impact on quality of life and is commonly misdiagnosed in clinical practice due to its complicated pathogenesis. In the present study, we performed non-targeted plasma metabolomics analysis of cervicitis in both plasma samples obtained from human patients and plasma samples from a phenol mucilage induced rat model of cervicitis, using ultra-performance liquid chromatography coupled to quadrupole time-of-flight tandem mass spectrometry. Read More

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http://dx.doi.org/10.3389/fphar.2018.00282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893906PMC
April 2018
13 Reads

Assessing prevalence of missed laboratory-confirmed sexually transmitted infections among women in Kingston, Jamaica: results from a secondary analysis of the Sino-Implant clinical trial.

BMJ Open 2018 04 13;8(4):e019913. Epub 2018 Apr 13.

Division of Reproductive Health, U.S. Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.

Objectives: To assess potentially missed sexually transmitted infections (STIs), we compared clinically diagnosed STIs to laboratory-confirmed diagnoses of gonorrhoea (GC), chlamydia (CT) and trichomonas (Tvag).

Design: Secondary analysis of a randomised controlled trial.

Setting: We used data and specimens previously collected for the Sino-Implant Study in Kingston, Jamaica. Read More

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http://dx.doi.org/10.1136/bmjopen-2017-019913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905734PMC
April 2018
14 Reads

Prevalence of and other sexually-transmitted pathogens among high-risk individuals in Greece.

Germs 2018 Mar 1;8(1):12-20. Epub 2018 Mar 1.

MD, PhD, FRCPath, Department of Microbiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Background: The aim of the present study was to determine the prevalence of (MG) infection among individuals at high risk for sexually-transmitted diseases (STDs) at a major urban STD clinic in Athens, in view of the lack of data pertaining to this infection in Greece.

Methods: Urethral and cervical samples from 176 individuals consecutively attending the clinic and agreeing to participate were prospectively collected and tested for MG infection using conventional PCR and TaqMan Real-Time PCR. All individuals were also examined for alternative STD pathogens. Read More

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http://dx.doi.org/10.18683/germs.2018.1128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845971PMC
March 2018
1 Read

[Prevalence and phylogenetic analysis of Chlamydia trachomatis in a population of women in Posadas, Misiones].

Rev Esp Quimioter 2018 Feb 16;31(1):21-26. Epub 2017 Feb 16.

Graciela Beatriz Jordá, Cátedra de Virología, Facultad de Ciencias Exactas, Químicas y Naturales, Universidad Nacional de Misiones. Luis Pasteur 1551. CP: 3300. Posadas, Misiones, Argentina.

Objective: Chlamydia trachomatis is the most prevalent bacteria causing sexually transmitted infections. In women, this infection can cause cervicitis and urethritis, although it's usually asymptomatic. The aim of this study was to investigate the prevalence of C. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159361PMC
February 2018
5 Reads

Prevalence of in different population groups: systematic review andmeta-analysis.

Sex Transm Infect 2018 06 9;94(4):255-262. Epub 2018 Feb 9.

Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.

Background: is a common cause of non-gonococcal non-chlamydial urethritis and cervicitis. Testing of asymptomatic populations has been proposed, but prevalence in asymptomatic populations is not well established. We aimed to estimate the prevalence of in the general population, pregnant women, men who have sex with men (MSM), commercial sex workers (CSWs) and clinic-based samples, METHODS: We searched Embase, Medline, IndMED, African Index Medicus and LILACS from 1 January 1991 to 12 July 2016 without language restrictions. Read More

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http://dx.doi.org/10.1136/sextrans-2017-053384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969327PMC
June 2018
9 Reads
3.400 Impact Factor

Ligneous cervicitis and endometritis: A gynaecological presentation of congenital plasminogen deficiency.

Haemophilia 2018 May 13;24(3):359-365. Epub 2018 Feb 13.

Department of Obstetrics and Gynaecology, The Royal Free Foundation NHS Trust, London, UK.

Background: Congenital plasminogen deficiency is a rare autosomal recessive condition. Plasminogen deficiency is thought to result in an inability of fibrin breakdown and therefore accumulation of fibrin and formation of ligneous changes. Ligneous lesions can form on a number of mucosal membranes including the cervix and endometrium. Read More

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http://doi.wiley.com/10.1111/hae.13418
Publisher Site
http://dx.doi.org/10.1111/hae.13418DOI Listing
May 2018
24 Reads
2.600 Impact Factor

Future of human Chlamydia vaccine: potential of self-adjuvanting biodegradable nanoparticles as safe vaccine delivery vehicles.

Expert Rev Vaccines 2018 03 6;17(3):217-227. Epub 2018 Feb 6.

a Department of Biological Sciences , Alabama State University , Montgomery , AL , USA.

Introduction: There is a persisting global burden and considerable public health challenge by the plethora of ocular, genital and respiratory diseases caused by members of the Gram-negative bacteria of the genus Chlamydia. The major diseases are conjunctivitis and blinding trachoma, non-gonococcal urethritis, cervicitis, pelvic inflammatory disease, ectopic pregnancy, tubal factor infertility, and interstitial pneumonia. The failures in screening and other prevention programs led to the current medical opinion that an efficacious prophylactic vaccine is the best approach to protect humans from chlamydial infections. Read More

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http://dx.doi.org/10.1080/14760584.2018.1435279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330895PMC
March 2018
12 Reads