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    Assessing prevalence of missed laboratory-confirmed sexually transmitted infections among women in Kingston, Jamaica: results from a secondary analysis of the Sino-Implant clinical trial.
    BMJ Open 2018 Apr 13;8(4):e019913. Epub 2018 Apr 13.
    Division of Reproductive Health, U.S. Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.
    Objectives: To assess potentially missed sexually transmitted infections (STIs), we compared clinically diagnosed STIs to laboratory-confirmed diagnoses of gonorrhoea (GC), chlamydia (CT) and trichomonas (Tvag).

    Design: Secondary analysis of a randomised controlled trial.

    Setting: We used data and specimens previously collected for the Sino-Implant Study in Kingston, Jamaica. Read More

    Prevalence of and other sexually-transmitted pathogens among high-risk individuals in Greece.
    Germs 2018 Mar 1;8(1):12-20. Epub 2018 Mar 1.
    MD, PhD, FRCPath, Department of Microbiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
    Background: The aim of the present study was to determine the prevalence of (MG) infection among individuals at high risk for sexually-transmitted diseases (STDs) at a major urban STD clinic in Athens, in view of the lack of data pertaining to this infection in Greece.

    Methods: Urethral and cervical samples from 176 individuals consecutively attending the clinic and agreeing to participate were prospectively collected and tested for MG infection using conventional PCR and TaqMan Real-Time PCR. All individuals were also examined for alternative STD pathogens. Read More

    [Prevalence and phylogenetic analysis of Chlamydia trachomatis in a population of women in Posadas, Misiones].
    Rev Esp Quimioter 2018 Feb 16;31(1):21-26. Epub 2017 Feb 16.
    Graciela Beatriz Jordá, Cátedra de Virología, Facultad de Ciencias Exactas, Químicas y Naturales, Universidad Nacional de Misiones. Luis Pasteur 1551. CP: 3300. Posadas, Misiones, Argentina.
    Objective: Chlamydia trachomatis is the most prevalent bacteria causing sexually transmitted infections. In women, this infection can cause cervicitis and urethritis, although it's usually asymptomatic. The aim of this study was to investigate the prevalence of C. Read More

    Prevalence of in different population groups: systematic review and meta-analysis.
    Sex Transm Infect 2018 Feb 9. Epub 2018 Feb 9.
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
    Background: is a common cause of non-gonococcal non-chlamydial urethritis and cervicitis. Testing of asymptomatic populations has been proposed, but prevalence in asymptomatic populations is not well established. We aimed to estimate the prevalence of in the general population, pregnant women, men who have sex with men (MSM), commercial sex workers (CSWs) and clinic-based samples, METHODS: We searched Embase, Medline, IndMED, African Index Medicus and LILACS from 1 January 1991 to 12 July 2016 without language restrictions. Read More

    Ligneous cervicitis and endometritis: A gynaecological presentation of congenital plasminogen deficiency.
    Haemophilia 2018 Feb 13. Epub 2018 Feb 13.
    Department of Obstetrics and Gynaecology, The Royal Free Foundation NHS Trust, London, UK.
    Background: Congenital plasminogen deficiency is a rare autosomal recessive condition. Plasminogen deficiency is thought to result in an inability of fibrin breakdown and therefore accumulation of fibrin and formation of ligneous changes. Ligneous lesions can form on a number of mucosal membranes including the cervix and endometrium. Read More

    Future of human Chlamydia vaccine: potential of self-adjuvanting biodegradable nanoparticles as safe vaccine delivery vehicles.
    Expert Rev Vaccines 2018 Mar 6;17(3):217-227. Epub 2018 Feb 6.
    a Department of Biological Sciences , Alabama State University , Montgomery , AL , USA.
    Introduction: There is a persisting global burden and considerable public health challenge by the plethora of ocular, genital and respiratory diseases caused by members of the Gram-negative bacteria of the genus Chlamydia. The major diseases are conjunctivitis and blinding trachoma, non-gonococcal urethritis, cervicitis, pelvic inflammatory disease, ectopic pregnancy, tubal factor infertility, and interstitial pneumonia. The failures in screening and other prevention programs led to the current medical opinion that an efficacious prophylactic vaccine is the best approach to protect humans from chlamydial infections. Read More

    Association between visual inspection of the cervix with acetic acid examination and high-risk human papillomavirus infection, Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis in Papua New Guinea.
    Aust N Z J Obstet Gynaecol 2018 Jan 30. Epub 2018 Jan 30.
    The Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
    Background: Papua New Guinea (PNG) has among the highest estimated burdens of cervical cancer globally but currently has no national cervical screening program. Visual inspection of the cervix with acetic acid (VIA) is a low-cost screening strategy endorsed by the World Health Organization that has been adopted in many low-resource settings but not previously evaluated in PNG.

    Aim: To evaluate the association between VIA examination findings and high-risk HPV (hrHPV) infection; and the impact of concomitant genital Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis on the interpretation of VIA findings. Read More

    Identifying acute cervicitis in an era of less-frequent routine gynecologic examinations.
    JAAPA 2018 Feb;31(2):50-53
    Margaret Allen is a former PA program director for the University of Worcester in the United Kingdom, former clinical instructor in the Stanford University primary care associate program, and practiced family medicine at Ravenswood Family Health Center in East Palo Alto, Calif. The author has disclosed no potential conflicts of interest, financial or otherwise.
    Acute inflammation of the uterine cervix can lead to serious problems such as pelvic inflammatory disease (PID), endometritis, and complications of pregnancy and childbirth. As intervals for routine gynecologic screening examinations lengthen, cervical infections, especially if asymptomatic, may be missed. Annual wellness examinations and other patient visits outside routine gynecologic cancer screening visits should include brief evaluation with sexual risk assessment and a gynecologic examination if indicated. Read More

    Effect of Dialyzable Leukocyte Extract on chronic cervicitis in patients with HPV infection.
    J Med Life 2017 Oct-Dec;10(4):237-243
    PLaboratory of Molecular Biomedicine I, ENMyH, Instituto Politécnico Nacional, Mexico.
    The objective of the study was to assess the clinical, histopathological and immunochemical changes induced by dialyzable leukocyte extract (DLE) treatment in patients with chronic cervicitis associated to HPV infection. Fifty-four female Mexican patients diagnosed with chronic cervicitis, cervical intra-epithelial neoplasia grade 1 (CIN 1) and HPV infection were divided into two groups: patients treated with placebo and patients treated with DLE. Clinical and colposcopy evaluations were performed before and after treatments. Read More

    Cervical Cancer Induction Enhancement Potential of Chlamydia Trachomatis: A Systematic Review.
    Curr Microbiol 2018 Jan 22. Epub 2018 Jan 22.
    Laboratory of Microbiology and Molecular Biology, Faculty of Medicine and Pharmacy of Fez (FMPF), Sidi Mohammed Ben Abdellah University (USMBA), Fez, Morocco.
    Human papillomavirus (HPV) persistent infection is the necessary but not sufficient cause of cervical cancer. Other co-factors are required to induce cell transformation that will evolve to malignant cervical cancer. These co-factors include physical elements, other sexually transmitted infections, and immune response. Read More

    Presence of histopathological premalignant lesions and infection caused by high-risk genotypes of human papillomavirus in patients with suspicious cytological and colposcopy results: A prospective study.
    Vojnosanit Pregl 2017 Jan;74(1):24-30
    Background/aim: In patients with premalignant cervical lesions, human papillomavirus (HPV) infection, at any moment, may be spontaneously eliminated, or may persist or transform cervical epithelium from a lower to a higher degree. Due to that, it is necessary to wisely select the patients who are at high risk of cancer development. The aim of the study was to establish the interdependence between a suspicious Papanicolaou (Pap) test and colposcopy with the infection caused by high-risk genotypes of human papillomavirus and the presence of premalignant cervical lesions. Read More

    Human papillomavirus (HPV) 18 genetic variants and cervical cancer risk in Taizhou area, China.
    Gene 2018 Mar 10;647:192-197. Epub 2018 Jan 10.
    Laboratory of Gynecologic Oncology, Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, Zhejiang, China. Electronic address:
    Human papillomavirus (HPV) type 18 is predominantly associated with the development of cervical adenocarcinomas, whereas data on HPV18 genetic variability in China are limited. HPV18 genetic variants were formed phylogenetic tree, including lineages A, B, and C. We aimed to evaluate the diversity of HPV18 genetic variants by sequencing the entire E6, E7 and L1 genes. Read More

    Uterine Prolapse: Should Hysterectomy Specimens be Subjected for Histopathological Examination?
    J Midlife Health 2017 Oct-Dec;8(4):179-182
    Department of Obstetrics and Gynaecology, Christian Medical College, Ludhiana, Punjab, India.
    Context: Uterine prolapse accounts for one of the common gynecological problems in India. The excised uterus is not expected to have any pathological finding other than atrophic endometrium and may be an ulcer because of the prolapse.

    Aims: The aim of this study is to assess the hysterectomy specimen for unsuspected pathology. Read More

    Human Papilloma Viruses and Their Genotype Distribution in Women with High Socioeconomic Status in Central Anatolia, Turkey: A Pilot Study.
    Med Sci Monit 2018 Jan 4;24:58-66. Epub 2018 Jan 4.
    Department of Obstetrics and Gynecology, Health Research System In Vitro Fertilization (HRS IVF) Center, Ankara, Turkey.
    BACKGROUND In the present study we retrospectively evaluated the results of outpatients who had an HPV analysis, and present objective evidence for the administration of preventive inoculation in our area. MATERIAL AND METHODS We retrospectively reviewed 532 outpatients who visited a single center between 2012 and 2016 and had an HPV infection analysis. The criteria for inclusion of patients with unhealthy cervix in the study were: erosion, chronic cervicitis, healed lacerations, hypertrophied cervix, and abnormal discharges from the cervix. Read More

    A proteomic profile of postpartum cervical repair in mice.
    J Mol Endocrinol 2018 Jan;60(1):17-28
    Department of BiologyAppalachian State University, Boone, North Carolina, USA
    A timely and complete uterine cervical tissue repair postpartum is of necessity to prevent obstetrical complications, such as cervicitis, ectropion, hemorrhage, repeated miscarriages or abortions and possibly preterm labor and malignancies. We recently characterized the morphological alterations, as well as changes in angiogenic expression profile in a mice uterine cervix during the immediate postpartum period. Here, we build on this previous study using a proteomic analysis to profile postpartum tissue changes in mice cervix during the same period, the first 48 h of postpartum. Read More

    Macrolide and fluoroquinolone resistance in Mycoplasma genitalium in two Swedish counties, 2011-2015.
    APMIS 2017 Dec 13. Epub 2017 Dec 13.
    Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, National Reference Laboratory for Sexually Transmitted Infections, Örebro University, Örebro, Sweden.
    Mycoplasma genitalium, causing non-gonococcal non-chlamydial urethritis and associated with cervicitis, has developed antimicrobial resistance (AMR) to both the macrolide azithromycin (first-line treatment) and the fluoroquinolone moxifloxacin (second-line treatment). Our aim was to estimate the prevalence of resistance, based on genetic AMR determinants, to these antimicrobials in the M. genitalium population in two Swedish counties, Örebro and Halland, 2011-2015. Read More

    Downregulation of nuclear and cytoplasmic Chibby is associated with advanced cervical cancer.
    Oncol Lett 2017 Dec 25;14(6):6632-6644. Epub 2017 Sep 25.
    Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan, R.O.C.
    Chibby has been identified as a putative tumor suppressor and antagonist to β-catenin, thereby controlling the Wnt signaling pathway. Chibby is typically downregulated in numerous types of cancer and may be associated with tumorigenesis. The present study aimed at clarifying the following: i) Whether Chibby antagonizes β-catenin in cervical cancer; ii) whether Chibby and β-catenin mRNA expression is associated with cancer progression; and iii) whether Chibby and β-catenin expression may be used as a biomarker. Read More

    Strain Types Have Diversified Regionally and Globally with Evidence for Recombination across Geographic Divides.
    Front Microbiol 2017 13;8:2195. Epub 2017 Nov 13.
    UCSF Benioff Children's Hospital Oakland Research Institute, Oakland, CA, United States.
    () is the leading cause of bacterial sexually transmitted diseases worldwide. The Multi Locus Sequence Typing (MLST) scheme is effective in differentiating strain types (ST), deciphering transmission patterns and treatment failure, and identifying recombinant strains. Here, we analyzed 323 reference and clinical samples, including 58 samples from Russia, an area that has not previously been represented in typing schemes, to expand our knowledge of the global diversification of STs. Read More

    Should we screen for the sexually-transmitted infection Mycoplasma genitalium? Evidence synthesis using a transmission-dynamic model.
    Sci Rep 2017 Nov 23;7(1):16162. Epub 2017 Nov 23.
    MRC Centre for Outbreak Analysis & Modelling, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, Norfolk Place, London, W2 1PG, UK.
    There is increasing concern about Mycoplasma genitalium as a cause of urethritis, cervicitis, pelvic inflammatory disease (PID), infertility and ectopic pregnancy. Commercial nucleic acid amplification tests (NAATs) are becoming available, and their use in screening for M. genitalium has been advocated, but M. Read More

    Public health approach to prevent cervical cancer in HIV-infected women in Kenya: Issues to consider in the design of prevention programs.
    Gynecol Oncol Rep 2017 Nov 16;22:82-88. Epub 2017 Oct 16.
    Department of Internal Medicine & Infectious diseases, University Hospital, Ghent, Belgium.
    Women living with HIV in Africa are at increased risk to be co-infected with Human Papilloma Virus (HPV), persistent high risk (HR) HPV infection and bacterial vaginosis (BV), which compounds HPV persistence, thereby increasing the risk for cervical dysplasia. New guidance from WHO in 2014 advocating for a "screen and treat" approach in resource poor settings is becoming a more widely recommended screening tool for cervical cancer prevention programs in such contexts. This review article summarizes the risk factors to be considered when designing a primary and secondary cervical prevention program in a post-vaccination era for HIV-infected women in Kenya. Read More

    National Institute of Allergy and Infectious Diseases workshop report: "Chlamydia vaccines: The way forward".
    Vaccine 2017 Oct 31. Epub 2017 Oct 31.
    Division of Microbiology and Infectious Diseases, NIAID, Bethesda, MD, USA.
    Chlamydia trachomatis (Ct), an intracellular pathogen, is the most common bacterial sexually transmitted infection. In addition to acute cervicitis and urethritis, Ct can lead to serious sequelae of significant public health burden including pelvic inflammatory disease (PID) and infertility. Ct control efforts have not resulted in desired outcomes such as reduced incidence and reinfection, and this highlights the need for the development of an effective Ct vaccine. Read More

    p16INK4a Expression in Cervical Lesions Correlates with Histologic Grading - a Tertiary Level Medical Facility Based Retrospective Study
    Asian Pac J Cancer Prev 2017 10 26;18(10):2643-2647. Epub 2017 Oct 26.
    Pathology Department, Tezpur Medical College, Tezpur, India. Email:
    p16INK4a is a tumor-suppressor protein and cyclin-dependent kinase (cdk) inhibitor that blocks cdk4- and cdk6-mediated pRb phosphorylation to inhibit E2F-dependent transcription and cell-cycle progression. Because the E7 protein of high-risk HPVs inactivates pRB, the resulting overexpression of p16INK4a may be a good marker for infection with high risk HPV types. Immunostaining of p16INK4a allows precise identification of even small CIN or cervical cancer lesions in biopsy sections and can help reduce inter-observer variation in the histopathological interpretation of cervical biopsy specimens. Read More

    Down-regulation of IFITM1 and its growth inhibitory role in cervical squamous cell carcinoma.
    Cancer Cell Int 2017 10;17:88. Epub 2017 Oct 10.
    Genecology Research Centre, Centre for Animal Health Innovation, Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Maroochydore, DC, QLD 4558 Australia.
    Background: Cervical cancer is a major cause of death in women worldwide. Interferon-induced transmembrane protein 1 (IFITM1) is involved in antivirus defense, cell adhesion, and carcinogenesis in different tissues. However, the role of gene in cervical squamous cell cancer is unclear. Read More

    Clinical efficacy of cryotherapy combined with interferon in the treatment of chronic cervicitis complicated with HPV infection.
    Pak J Pharm Sci 2017 Jul;30(4(Suppl.)):1505-1508
    Department of Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
    This paper aims to investigate the clinical curative effect and adverse reactions of cryotherapy combined with interferon in the treatment of chronic cervicitis complicated with HPV infection. 100 cases diagnosed with chronic cervicitis complicated with HPV infection from August 2014 to August 2015 in our hospital were selected and randomly divided into observation group (50 cases) and control group (50 cases). The preoperative and postoperative HPV-DNA changes were observed, and the vaginal discharge, time of decrustation and hemostasis, HPV negative conversion ratio and clinical efficacy were compared, to record the adverse reactions during treatment. Read More

    Epidemiology of infertility in China: a population-based study.
    BJOG 2018 Mar 28;125(4):432-441. Epub 2017 Dec 28.
    Department of Obstetrics and Gynaecology, Reproductive Medical Centre, Peking University Third Hospital, Beijing, China.
    Objective: To assess the current prevalence of and risk factors for infertility among couples of reproductive age in China.

    Design: Population-based cross-sectional study.

    Setting: We approached 25 270 couples in eight provinces/municipalities, of whom 18 571 (response rate 74%) were interviewed. Read More

    Prevalence of Sexually Transmitted Infections and Their Risk Factors among Female Sex Workers in Isfahan, Iran: A Cross-Sectional Study.
    J Int Assoc Provid AIDS Care 2017 Nov/Dec;16(6):608-614. Epub 2017 Oct 11.
    1 Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
    Objectives: Female sex workers (FSWs) are at high risk of sexually transmitted infections (STIs) and form a core group to facilitate STI spreading. We aimed to estimate the prevalence of STIs among FSWs who attended Female Harm Reduction Center of Isfahan, Iran, and to determine the association between risky behaviors and STIs.

    Study Design: In a cross-sectional study, 99 FSWs were recruited and interviewed about demographic characteristics and risky behaviors. Read More

    Chlamydia Infection Between Men and Women: A Cross-Sectional Study of Heterosexual Partnerships.
    Open Forum Infect Dis 2017 27;4(3):ofx160. Epub 2017 Sep 27.
    Melbourne Sexual Health Centre, Alfred Health, Victoria, Australia.
    Background: Studies of sexual partnerships can further our understanding of the sexual transmission of chlamydia, which is important for informing public health interventions and clinical management. The aim of this study was to ascertain among heterosexual dyads the proportion concordantly infected with chlamydia and factors associated with infection between partners.

    Methods: This study was conducted at the Melbourne Sexual Health Centre between January 2006 and March 2015. Read More

    Cyto-colpo-histologic correlation: about an analytical study of 120 colposcopies.
    Tunis Med 2016 Oct;94(10):616-620
    Problem: Cervical cancer is the second gynecological cancer Tunisian women after breast. This is a sexually transmitted disease including the role of HPV has been proven. Cervical cancer screening is possible due to the accessibility of the cervix with a speculum examination and implementation of cervical smear. Read More

    Cervical precancerous changes and selected cervical microbial infections, Kiambu County, Kenya, 2014: a cross sectional study.
    BMC Infect Dis 2017 09 25;17(1):647. Epub 2017 Sep 25.
    Department of Medical Laboratory Sciences, Kenyatta University, School of Medicine, P. O. Box 43844-00100, Nairobi, Kenya.
    Background: Cervical cancer is the predominant cancer among women in Kenya and second most common in women in developing regions. Population-based cytological screening and early treatment reduces morbidity and mortality associated with the cancer. We determined the occurrence of cervical precancerous changes and cervical microbial infections (Trichomonas vaginalis, Candida albicans, Neisseria gonorrhea and Actinomyces) among women attending Family Health Option Kenya (FHOK) clinic in Thika. Read More

    Clinical and analytical evaluation of the new Aptima Mycoplasma genitalium assay, with data on M. genitalium prevalence and antimicrobial resistance in M. genitalium in Denmark, Norway and Sweden in 2016.
    Clin Microbiol Infect 2017 Sep 18. Epub 2017 Sep 18.
    Infection Preparedness, Research Unit for Reproductive Tract Microbiology, Statens Serum Institut, Copenhagen, Denmark.
    Objectives: Mycoplasma genitalium (MG) causes urethritis and cervicitis, potentially causing reproductive complications. Resistance in MG to first-line (azithromycin) and second-line (moxifloxacin) treatment has increased. We examined the clinical and analytical performance of the new Conformité Européene (CE)/in vitro diagnostics (IVD) Aptima Mycoplasma genitalium assay (CE/IVD AMG; Hologic); the prevalence of MG, Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG); and MG resistance to azithromycin and moxifloxacin in Denmark, Norway and Sweden in 2016. Read More

    Detection of Human Papilloma virus by Molecular method from Patients Attending at Colposcopy Clinic of Mymensingh Medical College Hospital, Mymensingh.
    Mymensingh Med J 2017 Jul;26(3):600-607
    Dr Habiba Begum, Assistant Professor, Department of Microbiology, Delta Medical College, Mirpur, Dhaka, Bangladesh.
    Cervical cancer is the second most common cancer in women worldwide. Human papillomavirus (HPV) is considered as the main cause of invasive cervical cancer and cervical intra-epithelial neoplasia. High risk HPV DNA has been shown to be present in 99. Read More

    Comparative Study of Cytology and Histopathology of Cervical Lesion in VIA Positive Patients and Its Correlation with High Risk Human Papilloma Virus.
    Mymensingh Med J 2017 Jul;26(3):505-513
    Dr Nazma Parvin Ansari, Resident of Pathology, Mymensingh Medical College, Mymensingh, Bangladesh.
    Cervical cancer is the second most frequent type of cancer and leading cause of mortality among women worldwide. The present study was undertaken to assess precancerous and cancerous cervical lesion by cytology as well as HPV DNA identification and their comparison with histopathology in VIA positive cases. This descriptive, cross-sectional type of observational study was carried out in the Department of Pathology, Mymensingh Medical College in collaboration with the Department of Gynecology and Obstetrics, Mymensingh Medical College Hospital and Department of Microbiology and Hygiene in Bangladesh Agriculture University for HPV DNA detection from July 2012 to June 2013. Read More

    Distribution of Chlamydia Trachomatis Genotypes in Infective Diseases of the Female Lower Genital Tract.
    Med Sci Monit 2017 Sep 17;23:4477-4481. Epub 2017 Sep 17.
    Department of Gynecology, The People's Hospital of Liuzhou, Liuzhou, Guangxi, China (mainland).
    The purpose of this study was to investigate the distribution of Chlamydia trachomatis (CT) genotypes in infective diseases of the female lower genital tract, especially in cervical diseases. This study included 128 CT-positive women. DNA was extracted from cervical swabs. Read More

    Regression of uterine cervical diffuse large B-cell lymphoma transformed from mucosa-associated lymphoid tissue lymphoma subsequent to Chlamydia trachomatis eradication.
    Rinsho Ketsueki 2017 ;58(8):912-916
    Department of Pathology, Kurume University School of Medicine.
    A 37-year-old-woman was referred to our center after her uterine cervix health screening presented abnormal findings. We performed a biopsy of the uterine cervix to examine for cervical dysplasia, and diagnosed a diffuse large B-cell lymphoma transformed from mucosa-associated lymphoid tissue (MALT) lymphoma of the cervix. The patient presented with concurrent chlamydial cervicitis and received eradication therapy for Chlamydia trachomatis. Read More

    Prevalence and significance of Mycoplasma genitalium in women living with HIV in Denmark.
    BMC Res Notes 2017 Sep 7;10(1):468. Epub 2017 Sep 7.
    Statens Serum Institut, Copenhagen, Denmark.
    Objective: Mycoplasma genitalium (M. genitalium) is a sexually transmitted pathogen associated with urethritis, cervicitis, and pelvic inflammatory disease. Previous studies have shown a strong association between M. Read More

    Nanomechanical Characteristics of Cervical Cancer and Cervical Intraepithelial Neoplasia Revealed by Atomic Force Microscopy.
    Med Sci Monit 2017 Aug 31;23:4205-4213. Epub 2017 Aug 31.
    Department of Obstetrics and Gynecology, Peking University 3rd Hospital, Beijing, China (mainland).
    BACKGROUND Understanding the biological features and developmental progress of cervical cancer is crucial for disease prevention. This study aimed to determine the nanomechanical signatures of cervical samples, ranging from cervicitis to cervical carcinomas, and to investigate the underlying mechanisms. MATERIAL AND METHODS Forty-five cervical biopsies at various pathological stages were subjected to atomic force microscopy (AFM) measurements. Read More

    Correlation of P16 (Ink4a) and CK17 to HPV (16E6+18E6) in Premalignant and Malignant Lesions of Uterine Cervix: A Clinicopathologic Study.
    Iran J Pathol 2016 ;11(4):377-390
    Dept. of Pathology and Forensic medicine, College of Medicine, Al-Nahrain University, Baghdad, Iraq.
    Background: This research was accomplished to evaluate the IHC expression of p16 (ink4a) and CK17 in low grade cervical intraepithelial lesions (LSIL), high grade cervical intraepithelial lesions (HSIL) and invasive cervical carcinomas and to assess their correlation to HPV (16E6+18E6).

    Methods: The study included (127) formalin-fixed paraffin-embedded cervical biopsies; of which 22 cases were chronic cervicitis, 24 cases were LSIL, 28 cases were HSIL and 53 cases were invasive cervical carcinomas. Sections were immunohistochemically stained for p16 (ink4a), CK17 and HPV (16E6+18E6). Read More

    Developing a Public Health Response to Mycoplasma genitalium.
    J Infect Dis 2017 Jul;216(suppl_2):S420-S426
    Centers for Disease Control and Prevention, Atlanta, Georgia.
    Although Mycoplasma genitalium is increasingly recognized as a sexually transmitted pathogen, at present there is no defined public health response to this relatively newly identified sexually transmitted infection. Currently available data are insufficient to justify routinely screening any defined population for M. genitalium infection. Read More

    Mycoplasma genitalium in Women: Current Knowledge and Research Priorities for This Recently Emerged Pathogen.
    J Infect Dis 2017 Jul;216(suppl_2):S389-S395
    Departments of Epidemiology and Global Health, Center for AIDS and STD, University of Washington, Seattle.
    Health consequences of sexually transmitted diseases disproportionately affect women, making it important to determine whether newly emerged pathogens cause sequelae. Although the pathogenic role of Mycoplasma genitalium in male urethritis is clear, fewer studies have been conducted among women to determine its pathogenic role in the female reproductive tract. Pelvic inflammatory disease (PID) is an important cause of infertility and ectopic pregnancy, and Chlamydia trachomatis and Neisseria gonorrhoeae are recognized microbial causes. Read More

    The Unique Microbiology and Molecular Pathogenesis of Mycoplasma genitalium.
    J Infect Dis 2017 Jul;216(suppl_2):S382-S388
    Departments of 3 Medicine (Division of Infectious Diseases).
    Mycoplasma genitalium is increasingly appreciated as a common cause of sexually transmitted disease syndromes, including urethritis in men and cervicitis, endometritis, pelvic inflammatory disease, and possibly preterm birth, tubal factor infertility, and ectopic pregnancy in women. Despite these disease associations, which parallel those of Chlamydia trachomatis and Neisseria gonorrhoeae, the mechanisms by which this pathogen elicits inflammation, causes cellular damage, and persists in its only natural host (humans) are unique and are not fully understood. The purpose of this review is to briefly provide a historical background on the discovery, microbiology, and recognition of M. Read More

    Mycoplasma genitalium: Accurate Diagnosis Is Necessary for Adequate Treatment.
    J Infect Dis 2017 Jul;216(suppl_2):S406-S411
    Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland.
    Background: Mycoplasma genitalium is very difficult to grow in culture but has been more able to be studied for disease associations since the advent of research molecular amplification assays. Polymerase chain reaction (PCR) and other molecular assays have demonstrated an association with adverse disease outcomes, such as urethritis or nongonococcal urethritis in men and adverse reproductive sequelae in women-for example, cervicitis, endometritis, and pelvic inflammatory disease (PID), including an association with risk for human immunodeficiency virus. The lack of commercially available diagnostic assays has limited widespread routine testing. Read More

    Local and systemic immunomodulatory mechanisms triggered by Human Papillomavirus transformed cells: a potential role for G-CSF and neutrophils.
    Sci Rep 2017 Aug 21;7(1):9002. Epub 2017 Aug 21.
    Department of Immunology, Institute of Biomedical Sciences, Universidade de São Paulo, Av. Prof. Lineu Prestes, 1730, Ed. Biomédicas IV, 05508-900, São Paulo, SP, Brazil.
    Cervical cancer is the last stage of a series of molecular and cellular alterations initiated with Human Papillomavirus (HPV) infection. The process involves immune responses and evasion mechanisms, which culminates with tolerance toward tumor antigens. Our objective was to understand local and systemic changes in the interactions between HPV associated cervical lesions and the immune system as lesions progress to cancer. Read More

    Correlation of Cervical Pap Smear with Biopsy in the Lesion of Cervix.
    Kathmandu Univ Med J (KUMJ) 2016 Jul-Sept.;14(55):254-257
    Department of Gynecology and Obstetrics, Kathmandu University School of Medical Sciences, Dhulikhel, Kavre, Nepal.
    Background Cervical cancer can be controlled to a greater extent by screening to improve morbidity and mortality. Pap smear is important screening method, which has proven to be highly effective in reducing the number of cases and the mortality from cervical carcinoma. Any abnormality detected in pap smear has to be confirmed with cervical biopsy, which remains the reference investigation. Read More

    Application of a time-resolved fluoroimmunoassay for detection of p16INK4a in cervix.
    Ann Diagn Pathol 2017 Aug 12;29:7-10. Epub 2017 Apr 12.
    The First People's Hospital of Jingmen, Jingmen, 448000, People's Republic of China. Electronic address:
    Objective: To establish a time-resolved fluoroimmunoassay (TRFIA) method to detect p16INK4a.

    Methods: 119 cases of exfoliative cells following Thinprep cytologic test (TCT) test were selected for TRFIA and biopsy tissues of these patients according to TCT results were collected for immunohistochemical (IHC) staining.

    Results: There were 40 cases with cervicitis, 16 cases of cervical intraepithelial neoplasia grade 1 (CIN1), 15 cases of CIN2, 26 cases of CIN3, and 22 cases of squamous cell carcinoma (SCC). Read More

    STAT3 influences the characteristics of stem cells in cervical carcinoma.
    Oncol Lett 2017 Aug 21;14(2):2131-2136. Epub 2017 Jun 21.
    Department of Obstetrics and Gynecology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei 441000, P.R. China.
    The purpose of the study was to investigate the role of the signal transducer and activator of transcription 3 (STAT3), signal transduction protein in regulating the biological characteristics of stem cells in cervical carcinoma. Overexpressed plasmid of STAT3 was constructed and used to transfect SiHa into cervical carcinoma cells. STAT3-targeted specific siRNA was designed and produced. Read More

    The first case of lymphogranuloma venereum in a woman in East-Central Europe and its multiple co-infections.
    Folia Microbiol (Praha) 2018 Jan 24;63(1):93-95. Epub 2017 Jul 24.
    Department of Dermatovenereology, Second Faculty of Medicine, Charles University and Hospital Bulovka, Budinova 2, 180 81, Prague 8, Czech Republic.
    We are reporting the first case of lymphogranuloma venereum in women in East-Central Europe. A 22-year-old heterosexual woman attended our department of venereology. She complained about a burning sensation in the urethra and vaginal discharge. Read More

    Prevalence of cervical colonization by Ureaplasma parvum, Ureaplasma urealyticum, Mycoplasma hominis and Mycoplasma genitalium in childbearing age women by a commercially available multiplex real-time PCR: An Italian observational multicentre study.
    J Microbiol Immunol Infect 2018 Apr 28;51(2):220-225. Epub 2017 Jun 28.
    Microbiology Section, Department of Experimental Medicine, University of Perugia, Santa Maria della Misericordia Hospital, Sant'Andrea delle Fratte, 06129, Perugia, Italy.
    Background: Mycoplasmas are frequently isolated from the genital tract. New molecular PCR-based methods for the detection of mycoplasmas can better define the real epidemiology of these microorganisms. The aim of this study was to evaluate the prevalence of mycoplasmas in a population of childbearing age women by means of PCR. Read More

    Y Box-Binding Protein 1 Promotes Epithelial-Mesenchymal Transition, Invasion, and Metastasis of Cervical Cancer via Enhancing the Expressions of Snail.
    Int J Gynecol Cancer 2017 10;27(8):1753-1760
    *Departments of Obstetrics and Gynecology, †Pathology, Cancer Research Institute, Guangdong Medical University, Dongguan, China.
    Objective: Y box-binding protein 1 (YB-1) is a potent oncogenic protein. How it regulates Snail in most tumors including cervical cancer is unknown. This article is to study if YB-1 plays a role in cervical cancer via regulating the expression of Snail. Read More

    Cyto-colpo-histologic correlation: about an analytical study of 120 colposcopies.
    Tunis Med 2016 Oct;94(8-9):616-620
    Problem: Cervical cancer is the second gynecological cancer Tunisian women after breast. This is a sexually transmitted disease including the role of HPV has been proven. Cervical cancer screening is possible due to the accessibility of the cervix with a speculum examination and implementation of cervical smear. Read More

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