3,613 results match your criteria Cervicitis

Methylated as a triage marker for occult cervical cancer and advanced cervical intraepithelial neoplasia.

Future Oncol 2022 Jun 27. Epub 2022 Jun 27.

Gynecology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

To explore the appropriate triage methods for women infected with high-risk human papillomavirus (hrHPV). A total of 424 out of 872 hrHPV-infected women were divided into cervicitis (n = 123), cervical intraepithelial neoplasia grade 1 (CIN1; n = 89), CIN2 (n = 72), CIN3 (n = 87) and cervical cancer (n = 53) groups. The sensitivity/specificity of , and liquid-based cytology (LBC) for hrHPV-infected women with transformation zone 3 CIN3+ was 83. Read More

View Article and Full-Text PDF

Shotgun Lipidomics for Differential Diagnosis of HPV-Associated Cervix Transformation.

Metabolites 2022 May 31;12(6). Epub 2022 May 31.

National Medical Research Center for Obstetrics Gynecology and Perinatology Named after Academician V.I., Kulakov of the Ministry of Healthcare of Russian Federation, 117997 Moscow, Russia.

A dramatic increase in cervical diseases associated with human papillomaviruses (HPV) in women of reproductive age has been observed over the past decades. An accurate differential diagnosis of the severity of cervical intraepithelial neoplasia and the choice of the optimal treatment requires the search for effective biomarkers with high diagnostic and prognostic value. The objective of this study was to introduce a method for rapid shotgun lipidomics to differentiate stages of HPV-associated cervix epithelium transformation. Read More

View Article and Full-Text PDF

Chronic Cervicitis and Cervical Cancer Detection Based on Deep Learning of Colposcopy Images Toward Translational Pharmacology.

Front Pharmacol 2022 27;13:911962. Epub 2022 May 27.

Department of Dermatology, Hunan Provincial People's Hospital (The First-Affiliated Hospital of Hunan Normal University), Changsha, China.

With the rapid development of deep learning, automatic image recognition is widely used in medical development. In this study, a deep learning convolutional neural network model was developed to recognize and classify chronic cervicitis and cervical cancer. A total of 10,012 colposcopy images of 1,081 patients from Hunan Provincial People's Hospital in China were recorded. Read More

View Article and Full-Text PDF

The Pap smear in inflammation and repair.

Cytojournal 2022 30;19:29. Epub 2022 Apr 30.

Department of Pathology, Government Medical College, Nagpur, Maharashtra, India.

Cytology of the uterine cervix is one of the most widely utilized tests and is best known primarily for the cytologic changes seen in precancerous lesions and invasive cancer of the uterine cervix. The more common inflammatory conditions of cervicitis and vaginitis are close clinical differentials, especially when they give rise to excessive blood-stained vaginal discharge. These infective conditions also result in variation in the appearance of otherwise benign squamous and glandular cells in cervical cytology specimens. Read More

View Article and Full-Text PDF

Efficacy of Linn. Pod's Sitz Bath plus Vaginal Pessary in Syndromic Management of Abnormal Vaginal Discharge: A Randomized Controlled Trial.

Evid Based Complement Alternat Med 2022 25;2022:5769555. Epub 2022 May 25.

Faculty of Business and Management Studies, Koforidua Technical University, Koforidua, Ghana.

Objectives: Abnormal vaginal discharge () is a common public health problem that significantly disrupts the health-related quality of life (HRQoL). Syndromic management infers the concurrent treatment of two or more infections. Hence, a comparative, single-blind study was planned to determine the efficacy of ( Linn. Read More

View Article and Full-Text PDF

A micro-Raman spectroscopy study of inflammatory condition of human cervix: Probing of Tissues and blood plasma samples.

Photodiagnosis Photodyn Ther 2022 Jun 2:102948. Epub 2022 Jun 2.

Centre of Excellence for Biophotonics, Department of Atomic and Molecular Physics, Manipal Academy of Higher Education, Manipal, India. Electronic address:

The present study explores the application of the micro-Raman spectroscopy technique to discriminate normal and cervicitis condition from cervical malignancy by analyzing the Raman signatures of tissues and plasma samples of the same subjects. The Raman peaks from tissue samples at 1026 cm,1298 cm and 1243 cm are attributed to glycogen, fatty acids and collagen and are found to be reliable signatures capable of identifying cervicitis and normal condition from cervical cancer. The Raman signatures from plasma samples belonging to carbohydrates (578 cm), lipids (1059 cm) and nucleic acids (1077 cm,1341 cm and 1357 cm) are quite useful to classify various stages of cervix at par with tissue based diagnosis. Read More

View Article and Full-Text PDF

Histomorphological Evaluation of Non-Neoplastic Lesions of Uterine Cervix and a Correlation of the Lesion with the Clinical Factors.

Cardiovasc Hematol Agents Med Chem 2022 Jun 3. Epub 2022 Jun 3.

Department of Physiology, Government Erode Medical College, Perundurai, Erode, Tamilnadu - 638 052, India.

Aim: This study investigates the prevalence of non-malignant lesions of the cervix among various biopsy samples.

Methods: This case study consists of 50 cases of cervical biopsy for almost two years. The case history and clinical details of the patients were obtained. Read More

View Article and Full-Text PDF

Cervical Power Doppler Angiography with Micro Vessel Blood Flow Indices in the Auxiliary Diagnosis of Acute Cervicitis.

Diagnostics (Basel) 2022 May 3;12(5). Epub 2022 May 3.

Department of Biomedical Engineering, National Yangming Chiaotung University, Taipei 112304, Taiwan.

We have conducted cervical imaging of uterine and micro-vessel flow velocity waveforms in acute pelvic inflammatory disease (PID) by transvaginal power Doppler ultrasound (TVPDU) in order to explore the associations of sonographic parameters with simple and complex cervicitis. Thirty-eight patients with acute PID (26 with acute simple cervicitis and 12 with complex cervicitis) were enrolled for an assessment of vascular grading of cervix and micro-vessel flow velocity using TVPDU before treatment. Seven parameters, including vascular grading (VG), lowest pulsatility index (PI), resistance index (RI), peak systolic velocity (PS), end diastolic velocity (ED), time average maximum velocity (TAMV), and vascular index (VI = PS/ED), were measured and recorded. Read More

View Article and Full-Text PDF

Immune and microbiological disorders in women with infectious and inflammatory pathology of the cervix.

Klin Lab Diagn 2022 May;67(5):309-314

G.N. Gabrichevskogo Moscow research institute for epidemiologyµbiology.

Penetration into the female genital tract of infectious agents is associated with the cause of the onset of cervicitis. In most cases, these are sexually transmitted diseases (STDs). A high level of viral and bacterial load in the study of clinical material from women with infectious and inflammatory pathology (IVP) of the cervix affects the activity of innate immunity reactions. Read More

View Article and Full-Text PDF

The association between common urogenital infections and cervical neoplasia - A nationwide cohort study of over four million women (2002-2018).

Lancet Reg Health Eur 2022 Jun 21;17:100378. Epub 2022 Apr 21.

Center for Primary Health Care Research, Clinical Research Centre (CRC), Department of Clinical Sciences Malmö, Lund University, Skåne University Hospital, Jan Waldenströms gata 35, Malmö 205 02, Sweden.

Background: Cervical cancer is a major cause of mortality and morbidity in women worldwide. This study aimed to estimate the association between common urogenital infections and cervical neoplasia.

Methods: A multi-register national cohort study of 4,120,557 women aged ≥15 years (2002-2018) was conducted. Read More

View Article and Full-Text PDF

Analysis of Serum Levels of IFN-, IL-4, and TNF- in Patients with Cervicitis Complicated by HPV Infection and Their Clinical Significance.

J Healthc Eng 2022 13;2022:3374655. Epub 2022 Apr 13.

Gynecology Department, Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, China.

In order to investigate the expression levels of serum IFN-, IL-4, and tumor necrosis TNF- in patients with cervicitis complicated with human papillomavirus (HPV) infection and clinical significance, a retrospective study was conducted on 90 patients with chronic cervicitis complicated by HP V infection who visited our hospital from June 2020 to June 2021, and they are included in the research group. According to the degree of HPV infection, the patients are divided into low-risk HPV type group ( = 65 cases) and high-risk HPV type group ( = 25 cases); 50 patients with cervicitis (without HPV infection) who received treatment in our hospital are selected as control group 1. Fifty healthy women who underwent physical examination are selected as the control group 2. Read More

View Article and Full-Text PDF

Could combination of radical hysterectomy and radiation effective in the treatment of primary cervical signet ring cell carcinoma?: A rare case report.

Int J Surg Case Rep 2022 May 13;94:107083. Epub 2022 Apr 13.

Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Jakarta, Indonesia.

Introduction: Primary signet-ring cell carcinoma (PSRCC) of the uterine cervix mostly occurs due to the metastasis from the primary organ, such as the gastrointestinal tract or breast. This case describes the cervical PSRCC and its management as a rare case.

Presentation Of Case: The 39-year-old female came to undergo cancer screening. Read More

View Article and Full-Text PDF

Retrospective Analysis of Ugandan Men with Urethritis Reveals Mycoplasma genitalium and Associated Macrolide Resistance.

Microbiol Spectr 2022 04 12;10(2):e0230421. Epub 2022 Apr 12.

Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

The rising rates of antimicrobial resistance (AMR) in Mycoplasma genitalium globally and the association of this sexually transmitted infection (STI) with cervicitis, urethritis, and HIV are potentially of great public health concern. Data on the epidemiology of M. genitalium in men in sub-Saharan Africa are limited. Read More

View Article and Full-Text PDF

Diagnostic value of the QuickStripe™ chlamydia rapid test among high-risk women in Jakarta.

Int J STD AIDS 2022 May 28;33(6):570-574. Epub 2022 Mar 28.

Department of Dermatology and Venereology, Faculty of Medicine, 95338Universitas Indonesia, Jakarta, Indonesia.

Background: Difficulty in diagnosing infections, including chlamydial cervicitis, is a notable challenge in managing sexually transmitted infections in Indonesia. Gram staining is usually done to make a presumptive diagnosis despite its low sensitivity and specificity. Polymerase chain reaction (PCR) is considered the gold standard, but it is costly, technically demanding, and difficult to be performed in low-resource settings. Read More

View Article and Full-Text PDF

Analysis of Distributions of HPV Infection in Females with Cervical Lesions in the Western District of Beijing Chaoyang Hospital.

J Healthc Eng 2022 14;2022:5422748. Epub 2022 Mar 14.

Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing, China.

Objective: To analyze the distribution of human papilloma virus (HPV) infection in women with cervical lesions of different grades and analyze the relationship of high-risk HPV and cervical lesions in order to facilitate targeted prevention.

Methods: The infection status of HPV subtype was statistically analyzed in patients who underwent colposcopy examination from April 2017 to June 2019.

Results: The infection rate of HPV was 81. Read More

View Article and Full-Text PDF

Diagnostic value of colposcopy in patients with cytology-negative and HR-HPV-positive cervical lesions.

Arch Gynecol Obstet 2022 Mar 23. Epub 2022 Mar 23.

Department of Reproduction, The Second Affiliated Hospital of Kunming Medical University, Kunming, 650101, China.

Purpose: High-risk human papillomavirus (HR-HPV)-positive but cytology-negative cervical cancer screening results are not uncommon. This study aimed to investigate colposcopy's accuracy and diagnostic value in patients with cytology-negative HR-HPV-positive screening results.

Methods: This retrospective study included patients with HR-HPV-positive cytology-negative screening results who underwent electronic colposcopy with acetic acid and multi-point cervical biopsy, HPV typing (24 HPV subtypes), and quantitative HPV detection. Read More

View Article and Full-Text PDF

Clinical Importance of Superior Sensitivity of the Aptima TMA-Based Assays for Mycoplasma genitalium Detection.

J Clin Microbiol 2022 04 23;60(4):e0236921. Epub 2022 Mar 23.

Infection Preparedness, Research Unit for Reproductive Tract Microbiology, Statens Serum Institutgrid.6203.7, Copenhagen, Denmark.

Mycoplasma genitalium (MG) is a common cause of nongonococcal cervicitis and urethritis. We investigated the demographic and clinical characteristics of patients tested in Denmark with the Conformité Européenne (CE)/ diagnostics (IVD) Aptima Mycoplasma genitalium assay (CE/IVD AMG; Hologic) and examined the clinical significance of the higher sensitivity of the TMA-based MG assays. From March to June 2016, urogenital and extragenital specimens from consecutive attendees at a sexually transmitted infection clinic in Copenhagen, Denmark were tested with the CE/IVD AMG assay (TMA-based), the research-use-only MG Alt TMA-1 assay (Hologic), a laboratory-developed TaqMan B quantitative real-time PCR (qPCR), and the Aptima Combo 2 (CT/NG; Hologic). Read More

View Article and Full-Text PDF

Histopathological profile of cervical biopsies in northern Malawi: a retrospective cross-sectional study.

BMJ Open 2022 03 11;12(3):e048283. Epub 2022 Mar 11.

Clinical Department, Mzuzu Central Hospital, Mzuzu, Malawi.

Objectives: According to the WHO (2014), cervical cancer is the second most common cancer in women globally. More than 85% of the global cervical cancer morbidity and mortality occur in low-income and middle-income countries and the highest risk region is in Eastern and Southern Africa. Malawi has the highest age-standardised rate of cervical cancer in the world. Read More

View Article and Full-Text PDF

Diagnostic Usefulness of p16 Immunohistochemistry for some Epithelial Lesions in the Pathology Service of Sultan Qaboos University Hospital.

Maedica (Bucur) 2021 Dec;16(4):634-641

Pathology Department, College of Medicine and Health Sciences, Sultan Qaboos University, Oman.

This study is aiming to assess the diagnostic value of p16 immunohistochemistry (IHC) for a variety of epithelial lesions in the service provided by the Department of Pathology at Sultan Qaboos University Hospital (SQUH), Sultanate of Oman. This study would enhance pathologists' ability to diagnose and differentiate between different types of epithelial lesions reliably. This study is a retrospective observational cross-sectional study. Read More

View Article and Full-Text PDF
December 2021

Cervicovaginal Microbiota Predicts Clinical Presentation.

Front Microbiol 2021 10;12:790531. Epub 2022 Feb 10.

Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

infection of the female lower genital tract can present with a spectrum of phenotypes ranging from asymptomatic carriage to symptomatic cervical inflammation, or cervicitis. The factors that contribute to the development of asymptomatic or symptomatic infections are largely uncharacterized. We conducted a pilot study to assess differences in the cervicovaginal microbial community of patients presenting with symptomatic vs. Read More

View Article and Full-Text PDF
February 2022

Arginase is involved in cervical lesions progression and severity.

Immunobiology 2022 03 16;227(2):152189. Epub 2022 Feb 16.

Molecular Immuno-Oncology Laboratory, Monastir University, Monastir, Tunisia; Higher Institute of Biotechnology of Monastir, Monastir University, Monastir, Tunisia. Electronic address:

Background: Little is known about the relationship between arginase, an immunosuppressive enzyme, and cervical lesions. The present study is aimed at evaluating arginase activity in plasma and mRNA arginase isoforms expression in cervical cells of patients with abnormal cytology and identifying their relationship with Human papillomavirus (HPV) related parameters such as: HPV type, HPV circulating viral load and anti-HPV16 IgG.

Methods: This study included 77 women with cervical lesions and 95 matched controls. Read More

View Article and Full-Text PDF

2021 European guideline on the management of Mycoplasma genitalium infections.

J Eur Acad Dermatol Venereol 2022 May 19;36(5):641-650. Epub 2022 Feb 19.

WHO Collaborating Centre for Gonorrhoea and other STIs, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University Hospital, Örebro University, Örebro, Sweden.

Mycoplasma genitalium infection contributes to 10-35% of non-chlamydial non-gonococcal urethritis in men. In women, M. genitalium is associated with cervicitis and pelvic inflammatory disease (PID) in 10-25%. Read More

View Article and Full-Text PDF

Effect of Mirena placement on reproductive hormone levels at different time intervals after artificial abortion.

World J Clin Cases 2022 Jan;10(2):511-517

Department of Obstetrics and Gynecology, Zhejiang Taizhou Hospital, Taizhou 317000, Zhejiang Province, China.

Background: Improper methods of contraception greatly increase the risk of abortion, cervical or endometrial lesions, and the number of recurrent artificial abortions. These complications result in the deterioration of a patient's outcome. Further, the proportion of artificial abortions is highest among unmarried females. Read More

View Article and Full-Text PDF
January 2022

Characterization of allergic inflammation in chronic uterine cervicitis.

Clin Exp Immunol 2022 01;207(1):44-52

Department of Chinese Traditional Medicine, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, China.

Female genital tract chronic inflammation is common in clinics; the pathogenesis is not fully understood yet. House dust mite (HDM) involves the pathogenesis of many chronic diseases in human. This study aims to identify HDM-specific allergic response in the cervix of patients with cervical inflammation. Read More

View Article and Full-Text PDF
January 2022

Increasing the efficiency of the herd reproduction system by introducing innovative technologies into dairy farming in Northern Kazakhstan.

Vet World 2021 Nov 28;14(11):3028-3037. Epub 2021 Nov 28.

Laboratory of Livestock Breeding, SHOS Zarechnoye LLP, Kostanay, Republic of Kazakhstan.

Background And Aim: In recent years, Kazakhstan has increasingly imported breeding cows for dairy and beef production. To maintain and improve their breeding qualities of reproductive function, it is necessary to constantly monitor the herd reproduction system. The aim of this study was to increase the level of herd reproduction by introducing innovative technologies into dairy farms in Northern Kazakhstan. Read More

View Article and Full-Text PDF
November 2021

Complement Receptor 3 Mediates HIV-1 Transcytosis across an Intact Cervical Epithelial Cell Barrier: New Insight into HIV Transmission in Women.

mBio 2022 Jan 11:e0217721. Epub 2022 Jan 11.

Center for Microbial Pathogenesis, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.

Transmission of HIV across the mucosal surface of the female reproductive tract to engage subepithelial CD4-positive T cells is not fully understood. Cervical epithelial cells express complement receptor 3 (CR3) (integrin αβ or CD11b/CD18). In women, the bacterium Neisseria gonorrhoeae uses CR3 to invade the cervical epithelia to cause cervicitis. Read More

View Article and Full-Text PDF
January 2022

Pathological and Bacteriological Assessment of Reproductive Organ Disorders in She Camels in Somali, Eastern Ethiopia.

Vet Med (Auckl) 2021 29;12:371-379. Epub 2021 Dec 29.

School of Veterinary Medicine, Wolaita Sodo University, Wolaita Sodo, Ethiopia.

Background: Reproduction is a vital necessity for effective livestock production, and its productivity depends on the normal structure and function of the genital organs.

Methods: A study was carried out to characterize gross pathological lesions and identify aerobic bacteria from reproductive organ disorders of slaughtered she-camels () in the Fafen zone of the Somali Regional States of Ethiopia. All the available reproductive organ (50) samples were considered during sampling and cultured bacteriologically using a standard procedure. Read More

View Article and Full-Text PDF
December 2021

Detection of Neisseria gonorrhoeae or Chlamydia trachomatis from oral wash specimens using the Abbott RealTime CT/NG assay and the Cobas 4800 CT/NG assay: A prospective study.

J Infect Chemother 2022 Apr 17;28(4):480-485. Epub 2021 Dec 17.

Department of Urology, University of Occupational and Environmental Health, Kitakyushu, Japan.

Introduction: Isolating oropharyngeal Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) from oral wash specimens (OWSs) is uncommon. Therefore, we evaluated the performance of the Abbott RealTime CT/NG assay and the Cobas 4800 CT/NG assay in detecting NG and CT in OWSs.

Methods: This multicenter prospective study included 457 patients from 14 medical facilities suspected of having untreated male urethritis or female cervicitis from November 2014 to December 2015. Read More

View Article and Full-Text PDF

Mycoplasma genitalium and sexually transmitted infections: evidences and figures in a tertiary hospital.

Rev Esp Quimioter 2022 Feb 17;35(1):76-79. Epub 2021 Dec 17.

Juan M. García-Lechuz Moya, Servicio de Microbiología. Paseo Isabel La Católica 1-4, Hospital Universitario Miguel Servet, Zaragoza 50006. Spain.

Objective: Mycoplasma genitalium is an emerging cause of sexually transmitted infections (STIs) and has been implicated in non-gonococcal urethritis in men and cervicitis in woman. The aim of this study is determinate the incidence and pathogenicity of M. genitalium within the diagnosis of STIs detected from clinical samples in a third level hospital. Read More

View Article and Full-Text PDF
February 2022

Single-Cell RNA Sequencing Reveals Multiple Pathways and the Tumor Microenvironment Could Lead to Chemotherapy Resistance in Cervical Cancer.

Front Oncol 2021 26;11:753386. Epub 2021 Nov 26.

College of Life Sciences, Wuhan University, Wuhan, China.

Background: Cervical cancer is one of the most common gynecological cancers worldwide. The tumor microenvironment significantly influences the therapeutic response and clinical outcome. However, the complex tumor microenvironment of cervical cancer and the molecular mechanisms underlying chemotherapy resistance are not well studied. Read More

View Article and Full-Text PDF
November 2021