3,468 results match your criteria Cervicitis


Impact of cervicitis on performance of cervical cancer screening using HRHPV testing and visual evaluation in women living with HIV in Botswana.

Int J Gynaecol Obstet 2020 May 25. Epub 2020 May 25.

Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.

HIV co-infection and poor access to primary and secondary prevention mean cervical cancer mortality is highest in low- and middle-income countries (LMIC). In 2018, the World Health Organization (WHO) made a call to action for the elimination of cervical cancer. Achievement of this relies on scale-up of effective screening for pre-invasive disease. Read More

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http://dx.doi.org/10.1002/ijgo.13235DOI Listing

Cervicitis: Balancing the Goals of Empiric Therapy and Antimicrobial Stewardship to Improve Women's Health.

Sex Transm Dis 2020 Jun;47(6):387-388

From the Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL.

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http://dx.doi.org/10.1097/OLQ.0000000000001183DOI Listing

p16/Ki-67 dual-stained cytology used for triage in cervical cancer opportunistic screening.

Chin J Cancer Res 2020 Apr;32(2):208-217

Department of Gynecology and Obstetrics, The Third Hospital of Peking University, Beijing 100191, China.

Objective: To evaluate the efficiency of p16/Ki-67 dual stain used as a triage in cervical cancer screening.

Methods: In this study, we did 468 p16/Ki-67 dual stain in human papillomavirus (HPV) 16/18-positive or 12 other high-risk HPV (OHR-HPV) positive Thinprep cytologic test (TCT) atypical squamous cells of undetermined significance (ASCUS)/ lower-grade squamous intraepithelial lesion (LSIL) women. We evaluated the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the triage test. Read More

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http://dx.doi.org/10.21147/j.issn.1000-9604.2020.02.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219095PMC

A Sensitive and Simplified Classifier of Cervical Lesions Based on a Methylation-Specific PCR Assay: A Chinese Cohort Study.

Cancer Manag Res 2020 15;12:2567-2576. Epub 2020 Apr 15.

Maternal and Child Health Hospital of Hubei Province and Women and Children's Hospital of Hubei Province, Wuhan, Hubei, People's Republic of China.

Objective: The aim of this study is to assess the diagnostic and screening performance of a standardized methylation-specific real-time PCR assay targeting and genes for cervical cancer in a Chinese cohort.

Methods: Genomic DNA was extracted from cervical exfoliated cells and converted by sodium bisulfite and then analyzed by qMSP assay. Ct values were collected for and as target genes and as an endogenous reference gene. Read More

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http://dx.doi.org/10.2147/CMAR.S246103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167279PMC

Characteristics of urogenital infections in a diverse patient sample from the United States; results from the Aptima Mycoplasma genitalium Evaluation Study (AMES).

J Clin Microbiol 2020 Apr 22. Epub 2020 Apr 22.

Hologic, Inc. 20120 Genetic Center Dr, San Diego CA 92121.

Data from a large prospective multicenter clinical validation study of a nucleic acid amplification diagnostic test for were analyzed to describe the prevalence of infection, risk factors, and disease associations in female and male patients seeking care in diverse geographic regions of the United States. Among 1737 female and 1563 male participants, overall prevalence was ∼10%, and was significantly higher in persons ages 15-24 compared to ages 35-39 (female: 19.8% vs. Read More

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http://dx.doi.org/10.1128/JCM.00165-20DOI Listing

[The value of P16/ki67 double labeling, HPV E6/E7 mRNA detection and their combined application in cytological shunt diagnosis of low-grade squamous intraepithelial lesions].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2020 Jan;36(1):63-68

Department of Pathology, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China.

Objective To explore the value of double labeling of P16/ki67, E6/E7 mRNA of human papillomavirus (HPV) and combined detection in shunt diagnosis of low-grade squamous intraepithelial lesions (LSIL) by thin-layer cervical cytology (TCT). Methods The study enrolled 239 patients who underwent colposcopy and biopsy within 4 weeks after primary TCT diagnosis. The remaining cytological samples were double-labeled with P16/ki67 immunocytochemical staining and the HPV E6/E7 mRNA was detected by Panther automatic HPV E6/E7 mRNA detection system. Read More

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January 2020

The Role of and Promoter Methylation in Inflammation and Cervical Intraepithelial Neoplasia.

Genet Test Mol Biomarkers 2020 May 20;24(5):256-263. Epub 2020 Apr 20.

Division of Oncology, Jessenius Faculty of Medicine, Biomedical Center Martin, Comenius University in Bratislava, Martin, Slovakia.

This study investigated the presence of human papillomavirus (HPV) infection and the methylation status of the promoters of the cell adhesion molecule 1 () gene and T lymphocyte maturation associated protein () gene in patients with cervicitis/inflammation and cervical intraepithelial neoplasia (CIN). Cervical specimens ( = 47) were collected from women with normal cervical cytology ( = 21) and those with cervical abnormalities ( = 26). The presence of HPV infection was confirmed by an HPV DNA test and an HPV mRNA test (Aptima HPV test). Read More

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http://dx.doi.org/10.1089/gtmb.2019.0188DOI Listing

A case of possible resistance in a woman.

Int J Womens Dermatol 2020 Mar 19;6(2):116-117. Epub 2019 Nov 19.

National AIDS Program, Beirut, Lebanon.

(MG) is an increasingly recognized sexually transmitted infection. In women, MG is particularly associated with endometritis, cervicitis, pelvic inflammatory disease, HIV, and long-term negative reproductive health and obstetric outcomes. In addition, MG has the potential to show resistance to antibiotics. Read More

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http://dx.doi.org/10.1016/j.ijwd.2019.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105642PMC

Description of Referrals for Colposcopy in a Hospital in Brazil.

Rev Bras Ginecol Obstet 2020 Mar 31;42(3):140-145. Epub 2020 Mar 31.

Department of Gynecology, Universidade de Taubaté, Taubaté, SP, Brazil.

Objective:  To describe the referral for colposcopy in a Hospital in Brazil and the relative frequency of patients who benefited from it, considering the correct indications for the examination and its final diagnoses.

Methods:  A retrospective study was performed in the colposcopy service database of the Hospital Universitário de Taubaté, Taubaté, state of São Paulo, Brazil. The frequency validated in the analysis of the medical records of women referred for clinical indication or cytological alteration, attended from March 2015 to March 2017. Read More

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http://dx.doi.org/10.1055/s-0040-1708886DOI Listing

Evaluation of the prevalence of sexually transmitted bacterial pathogens in Northern Cyprus by nucleic acid amplification tests, and investigation of the relationship between these pathogens and cervicitis.

Turk J Obstet Gynecol 2019 Dec 28;16(4):242-248. Epub 2020 Feb 28.

Near East University Faculty of Medicine, Department of Obstetrics and Gynecology, Nicosia, Northern Cyprus.

Objective: To evaluate the prevalence of pathogens, , and , , , , and in women via multiplex-polymerase chain reaction (PCR)-deoxyribonucleic acid (DNA).

Materials And Methods: Cervical swabs of 273 women in reproductive age who underwent gynecologic examination in our outpatient clinic were evaluated using the multiplex-PCR-DNA method. The presence of cervicitis, contraceptive methods, marital status, and the number of partners were evaluated. Read More

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http://dx.doi.org/10.4274/tjod.galenos.2019.80269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090263PMC
December 2019

Scientific Evaluation of Medicinal Plants Used for the Treatment of Cervicitis (Qorohe- Rahem) in Iranian Traditional Medicine.

Iran J Pharm Res 2019 ;18(4):1884-1901

Department of Traditional Pharmacy, School of Traditional Medicine, Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Cervicitis is an inflammatory condition of the cervix associated with upper genital tract infection and reproductive complications. Treatment for cervicitis in conventional system is the use of antibiotics and antifungal therapies and surgical interventions, but none of these treatments provides the definite efficacy in spite of high cost and side effect. So there is a need for an alternate therapy which is safe, effective, easily available and free from side effects. Read More

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http://dx.doi.org/10.22037/ijpr.2019.1100852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059029PMC
January 2019

Reconsidering Presumptive Neisseria gonorrhoeae Treatment For Women With Cervicitis.

Sex Transm Dis 2020 Jun;47(6):383-386

From the Department of Medicine, Section of Infectious Diseases, School of Medicine, Louisiana State University Health Sciences Center.

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http://dx.doi.org/10.1097/OLQ.0000000000001156DOI Listing

Positive staining of the immunoligand B7-H6 in abnormal/transformed keratinocytes consistently accompanies the progression of cervical cancer.

BMC Immunol 2020 03 6;21(1). Epub 2020 Mar 6.

Instituto de Enfermedades Crónico Degenerativas, Departamento de Biología Molecular y Genómica, CUCS, Universidad de Guadalajara, Sierra Mojada # 950, Colonia Independencia, CP 44340, Guadalajara, Jalisco, Mexico.

Background: B7-H6 has been revealed as an endogenous immunoligand expressed in a variety of tumors, but not expressed in healthy tissues. Heretofore, no studies have been reported describing B7-H6 in women with cervical cancer. To investigate this question, our present study was conducted. Read More

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http://dx.doi.org/10.1186/s12865-020-0341-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059382PMC

Syndromic management of sexually transmitted infections: A critical appraisal and the road ahead.

Natl Med J India 2019 May-Jun;32(3):147-152

Department of Dermatology and Venereology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.

The syndromic approach has been the cornerstone of management of sexually transmitted infections (STIs) in developing countries. This strategy has had a considerable impact in decreasing the burden of STI in society. It offers the advantages of treating the infection at the first visit itself, reducing the risk of complications, non-reliance on laboratory diagnostics, and easy integration into the primary healthcare system. Read More

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http://dx.doi.org/10.4103/0970-258X.278691DOI Listing

Repurposed Drugs That Block the Gonococcus-Complement Receptor 3 Interaction Can Prevent and Cure Gonococcal Infection of Primary Human Cervical Epithelial Cells.

mBio 2020 Mar 3;11(2). Epub 2020 Mar 3.

Institute for Glycomics, Griffith University, Southport, Queensland, Australia

In the absence of a vaccine, multidrug-resistant has emerged as a major human health threat, and new approaches to treat gonorrhea are urgently needed. pili are posttranslationally modified by a glycan that terminates in a galactose. The terminal galactose is critical for initial contact with the human cervical mucosa via an interaction with the I-domain of complement receptor 3 (CR3). Read More

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http://dx.doi.org/10.1128/mBio.03046-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064771PMC

The frontiers of addressing antibiotic resistance in Neisseria gonorrhoeae.

Transl Res 2020 Feb 29. Epub 2020 Feb 29.

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts; Center for Communicable Disease Dynamics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

The sexually transmitted infection gonorrhea, caused by the Gram-negative bacterium Neisseria gonorrhoeae, can cause urethritis, cervicitis, and systemic disease, among other manifestations. N. gonorrhoeae has rapidly rising incidence along with increasing levels of antibiotic resistance to a broad range of drugs including first-line treatments. Read More

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http://dx.doi.org/10.1016/j.trsl.2020.02.002DOI Listing
February 2020

The Chinese herbal prescription JZ-1 induces autophagy to protect against herpes simplex Virus-2 in human vaginal epithelial cells by inhibiting the PI3K/Akt/mTOR pathway.

J Ethnopharmacol 2020 May 20;254:112611. Epub 2020 Feb 20.

Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address:

Ethnophamacological Relevance: The Chinese herbal prescription JieZe-1 (JZ-1) is based on the modification of Yihuang Tang, which was first described in Fu Qingzhu Nvke by the famous Qing Dynasty doctor Shan Fu as a treatment for leukorrheal diseases. As an in-hospital preparation, JZ-1 has been used in Tongji Hospital for many years to treat various infectious diseases of the lower female genital tract, including cervicitis, vaginitis, genital herpes and condyloma acuminatum. Our previous studies have shown that JZ-1 has curative effects on Candida albicans, Trichomonas vaginalis and Ureaplasma urealyticum infections. Read More

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http://dx.doi.org/10.1016/j.jep.2020.112611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126429PMC

Relevance research between the expression of p16 , Notch1, and hTERC genes: The development of HPV16-positive cervical cancer.

J Clin Lab Anal 2020 May 24;34(5):e23207. Epub 2020 Jan 24.

Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao, China.

Background: GLOBOCAN 2018 latest data show cervical cancer ranks fourth in morbidity and mortality among women. Many genes in cervical lesions differ in sensitivity and specificity. However, the diagnostic molecules for early cervical cancer are not very clear. Read More

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http://dx.doi.org/10.1002/jcla.23207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246350PMC

Reliability of conventional Papanicolaou smear in diagnosing bacterial vaginosis among women with clinical genital infection.

South Asian J Cancer 2020 Jan-Mar;9(1):13-16

Department of Health Disparities Research, Division of Cancer Prevention and Population Science, MD Anderson Cancer Centre, Houston, USA.

Objective: Bacterial vaginosis (BV) is a common reproductive tract infection (RTI) reported among Indian women. BV can influence the persistence of high-risk oncogenic human papillomavirus, a causative factor for cervical cancer. BV and cervical cancer are major public health issues in a developing country like India. Read More

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http://dx.doi.org/10.4103/sajc.sajc_421_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956588PMC
January 2020

Prevalence and incidence of in a cohort of HIV-infected and HIV-uninfected pregnant women in Cape Town, South Africa.

Sex Transm Infect 2020 Jan 13. Epub 2020 Jan 13.

Epidemiology, University of California Los Angeles Jonathan and Karin Fielding School of Public Health, Los Angeles, California, USA.

Objective: (MG) is a sexually transmitted organism associated with cervicitis and pelvic inflammatory disease in women and has been shown to increase the risk of HIV acquisition and transmission. Little is known about the prevalence and incidence of MG in pregnant women. Our study sought to evaluate the prevalence and incidence of MG infection in HIV-infected and HIV-uninfected pregnant women. Read More

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http://dx.doi.org/10.1136/sextrans-2019-054255DOI Listing
January 2020
3.401 Impact Factor

Multiplex nested polymerase chain reaction targeting multiple genes for the detection of and in genitourinary specimens.

Indian J Sex Transm Dis AIDS 2019 Jul-Dec;40(2):152-158

Department of Dermatology and Venerology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Objectives: The objective of this study was to design and evaluate a novel multiplex nested polymerase chain reaction (PCR) protocol for simultaneous detection of and in genitourinary specimens obtained from symptomatic patients clinically suspected of sexually transmitted infections (STIs), targeting two different genes each for these pathogens.

Materials And Methods: A total of 116 genitourinary specimens were collected from men ( = 12) and women ( = 104). Direct microscopy, culture isolation, and antimicrobial susceptibility testing for were performed. Read More

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http://dx.doi.org/10.4103/ijstd.IJSTD_73_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896390PMC
January 2020

A profile of the cobas® TV/ MG test for the detection of and .

Expert Rev Mol Diagn 2020 Apr 18;20(4):381-386. Epub 2020 Jan 18.

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

: and are highly prevalent sexually transmitted pathogens that may be asymptomatic or may cause cervicitis and pelvic inflammatory disease in women and urethritis in men. Our limited understanding of the epidemiology of these infections has been hampered by a lack of diagnostic capacity, but the new cobas® TV/MG assay runs on the cobas® 6800/8800 platform offers a solution to this gap in our current diagnostic capacity.: This article will describe what we know about the epidemiology and impact of untreated infections with these organisms as well as current recommendations for testing. Read More

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http://dx.doi.org/10.1080/14737159.2020.1714440DOI Listing

[Screening of cervical sexually transmitted infections in pregnant women and the relation with the vaginal microbiota].

Rev Chilena Infectol 2019 Jun;36(3):292-298

Servicio de Dermatología y Venereología, Hospital San José, Santiago, Chile.

Background: Pregnant woman is exposed to many sexual transmitted infections (STI). Many of these infections may produce diseases in the fetus and newborn, and also alteration in the normal course of the pregnancy.

Aim: Screening of asymptomatic cervical infection in pregnant woman and its relationship with the vaginal microbiota. Read More

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http://dx.doi.org/10.4067/S0716-10182019000300292DOI Listing

Correlation between cervical carcinogenesis and tobacco use by sexual partners.

Hell J Nucl Med 2019 Sep-Dec;22 Suppl 2:184-190

Leof. Vas. Georgiou A' 8, 54640, Thessaloniki, Macedonia, Greece.

Purpose: Investigating the effects of active smoking, passive smoking and semen of tobacco smoking sexual partners on the carcinogenesis of uterine cervix.

Introduction: It is now well-established that persistence of Human Papillomavirus (HPV) infection is the strongest epidemiologic factor associated with intraepithelial neoplasia and cancer of cervix, as well as in other related locations such as in the vagina, vulva, anus, oral cavity, etc. A 1999 study indicates that the worldwide HPV prevalence in cervical carcinomas is 99,7 per cent. Read More

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[Study on Dynamic Changes of Human Papillomavirus 16 Gene in the Occurrence of Cervical Cancer].

Sichuan Da Xue Xue Bao Yi Xue Ban 2019 Sep;50(5):666-671

Department of Microbiology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.

Objective: To explore the dynamic changes of human papillomavirus (HPV) type 16 5 gene in the development of cervical cancer and the significance of 5 mRNA in early screening of cervical cancer.

Methods: Paraffin specimens of cervical lesions were collected from 49 cases (HPV positive) during September 2015 to December 2017 According to the standard of FIGO, all cervical lesions were diagnosed as: 13 cases of cervicitis, cervical intraepithelial neoplasia disorders (CIN) Ⅰ in 5 cases, CIN Ⅱ in 18 cases, CIN Ⅲ in 5 cases, 8 cases of cervical cancer. Real-time fluorescence quantitative PCR was used to detect the integrity of 5 gene and the mRNA expression levels of 5, 6 and 7in cervical tissues. Read More

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September 2019

Mycoplasma genitalium prevalence in Welsh sexual health patients: Low antimicrobial resistance markers and no association of symptoms to bacterial load.

Microb Pathog 2020 Feb 19;139:103872. Epub 2019 Nov 19.

Cardiff University, School of Medicine, Division of Infection and Immunity, Department of Medical Microbiology, University Hospital of Wales, Cardiff, CF14 4XN, United Kingdom; Department of Integrated Sexual Health, Dewi Sant Hospital, Cwm Taf Morgannwg University Health Board, Pontypridd, CF37 1LB, United Kingdom.

Objectives: Mycoplasma genitalium (MG) is a common cause of sexually transmitted infection, however no prevalence data is available for Wales. MG was detected by qPCR (quantitative) as well as two separate SpeeDx commercial assays, and related to clinical symptoms, age, gender and sample type.

Methods: Cervical swabs, urethral swabs and/or urine were collected from 1000 patients at walk-in sexual health clinics at 3 Welsh health centres from October 2017-October 2018. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.103872DOI Listing
February 2020

Gonorrhoea.

Nat Rev Dis Primers 2019 11 21;5(1):79. Epub 2019 Nov 21.

Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

The bacterium Neisseria gonorrhoeae causes the sexually transmitted infection (STI) gonorrhoea, which has an estimated global annual incidence of 86.9 million adults. Gonorrhoea can present as urethritis in men, cervicitis or urethritis in women, and in extragenital sites (pharynx, rectum, conjunctiva and, rarely, systemically) in both sexes. Read More

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http://dx.doi.org/10.1038/s41572-019-0128-6DOI Listing
November 2019
8 Reads

Uterine cervix as a fundamental part of the pathogenesis of pregnancy loss associated with ascending placentitis in mares.

Theriogenology 2020 Mar 14;145:167-175. Epub 2019 Oct 14.

Gluck Equine Research Center, University of Kentucky, Lexington, KY, 40546, USA. Electronic address:

Anatomical and molecular changes in the cervical barrier in women are a fundamental part of the pathogenesis of pregnancy loss associated with chorioamnionitis. However, there is little information regarding changes in the cervix associated with ascending infection in pregnant mares. To better characterize morphological and molecular changes in the cervix during placentitis, we examined full thickness histology and mRNA expression for a number of inflammatory and endocrine factors in the mucosa and stroma of the cervix of mares (n = 5) after experimental induction of placentitis via transcervical inoculation with Streptococcus equi ssp zooepidemicus at approximately 290d of gestation. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2019.10.017DOI Listing

Urogenital chlamydia trachomatis treatment failure with azithromycin: A meta-analysis.

Int J Reprod Biomed (Yazd) 2019 Sep 22;17(9):603-620. Epub 2019 Sep 22.

Noor Research Center for Ophthalmic Epidemiology Noor Eye Hospital Tehran Iran.

Background: Chlamydia Trachomatis is one of the most common pathogens transmitted through the genital tract in humans that leads to urogenital infection.

Objective: Given the high prevalence of chlamydia infection and its adverse effects on the health of women and men, the present meta-analysis was conducted to determine the rate of treatment failure with azithromycin.

Materials And Methods: Databases including MEDLINE, ISI - Web of Science, PubMed, EMBASE, Scopus, ProQuest, and Science Direct were searched for articles published between 1991 and 2018. Read More

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http://dx.doi.org/10.18502/ijrm.v17i9.5093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804326PMC
September 2019
1 Read

[Clinical Value of Peripheral Blood Circulating Tumor Cells Detection in Early Cervical Infiltrating Carcinoma Screening].

Sichuan Da Xue Xue Bao Yi Xue Ban 2019 May;50(3):415-419

Department of Pathology, Zhongshan Boai Hospital Affiliated to Southern Medical University, Zhongshan 528400, China.

Objective: To observe the difference of circulating tumor cells (CTC) in peripheral blood of patients with different degrees of cervical lesions, and to evaluate the effectiveness of CTC detection in screening early invasive cervical cancer.

Methods: From December 2015 to October 2017, 63 cases of cervicitis, low-grade and high-grade intraepithelial lesions (LSIL, HSIL) and early invasive cervical cancer were confirmed by histopathological and clinical stages in Zhongshan Boai Hospital and Zhongshan Hospital Affiliated to Zhongshan University. The immunomagnetic bead negative enrichment technique combined with immunofluorescence was used. Read More

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May 2019
2 Reads

HPV infection associated DNA damage correlated with cervical precancerous lesions and cancer in the highest area of cervical cancer mortality, Longnan, China.

Cancer Manag Res 2019 30;11:7197-7210. Epub 2019 Jul 30.

Department of Medical Function, Medical College of Northwest Minzu University, Lanzhou 730030, People's Republic of China.

Objectives: This study was to assess whether human papillomavirus (HPV) resulting in genetic instability is one reason for the high incidence and mortality of cervical cancer in Longnan.

Methods: Between 2012 and 2016, a total of 346 samples from Longnan were collected and divided into four groups: cervicitis group (n=57), cervical intraepithelial neoplasia I group (CIN I, n=63), CIN II/III group (n=79) and invasive squamous cell carcinoma group (SCC, n=147). HPV E6/E7 mRNA was detected by Quantivirus HPV E6/E7 RNA 3. Read More

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http://dx.doi.org/10.2147/CMAR.S201415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681565PMC
July 2019
1 Read

Downregulation of Mad2 and BubR1 increase the malignant potential and nocodazole resistance by compromising spindle assembly checkpoint signaling pathway in cervical carcinogenesis.

J Obstet Gynaecol Res 2019 Dec 15;45(12):2407-2418. Epub 2019 Sep 15.

Department of Obstetrics and Gynecology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China.

Aim: To explore the involvement of Mad2 and BubR1 in cervical carcinogenesis.

Methods: The expressions of Mad2 and BubR1 in tissues of high-grade squamous intraepithelial lesions (HSIL), low-grade squamous intraepithelial lesions (LSIL) and chronic cervicitis were analyzed immunohistochemistrily and compared with those of p16 . PEGFP-Mad2 and pEGFP-BubR1 were transfected into SiHa cells to overexpress Mad2 and BubR1 and Si-RNAs to knockdown. Read More

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http://dx.doi.org/10.1111/jog.14120DOI Listing
December 2019
1 Read
0.931 Impact Factor

Utility of human papillomavirus L1 capsid protein and HPV test as prognostic markers for cervical intraepithelial neoplasia 2+ in women with persistent ASCUS /LSIL cervical cytology.

Int J Med Sci 2019 6;16(8):1096-1101. Epub 2019 Aug 6.

Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Efficient and highly predictive biomarkers reflecting the prognosis of persistent atypical squamous cells of unknown significance(ASCUS) and low grade squamous intraepithelial lesion(LSIL)s are unavailable and need to be developed urgently. We aimed to develop a predictive model for diagnosis of cervical intraepithelial neoplasia(CIN)2+ by analyzing the immunocytochemical expression of the HPV L1 capsid protein in patients with persistent ASCUS and LSIL with a high risk of HPV infection. : Cervical cytology samples comprising (70 ASCUS and 215 LSIL Pap smears) were analyzed. Read More

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http://dx.doi.org/10.7150/ijms.31163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743270PMC
January 2020
4 Reads

Mycoplasma genitalium, a stealth female reproductive tract.

Eur J Clin Microbiol Infect Dis 2020 Feb 14;39(2):229-234. Epub 2019 Sep 14.

Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.

Mycoplasma genitalium was first isolated from the urethral swabs of two symptomatic men with urethritis in 1980. It is a sexually transmitted bacterium associated with a number of urogenital conditions in women like cervicitis, endometritis, pelvic inflammatory disease, infertility, and susceptibility to human immunodeficiency virus (HIV). However, M. Read More

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http://dx.doi.org/10.1007/s10096-019-03707-8DOI Listing
February 2020
3 Reads

Characteristics of carcinogenic HPV genotypes in North China Plain and the association with cervical lesions.

Medicine (Baltimore) 2019 Sep;98(37):e17087

Department of Gynecology, Affiliated Hospital of Jining Medical University, Jining Medical University, 89 Guhuai Road, Jining, Shandong, PR China.

Human papillomavirus (HPV) infection is a crucial health problem and caused substantial malignancy diseases among female worldwide. We aim to investigate the distribution of HPV subtype and the status of cervical cancer and precancerous lesions caused by HPV infection in North China Plain population. A total of 61,870 samples of outpatients and inpatients from January 2015 to May 2017 at the Affiliated Hospital of Jining Medical University were collected. Read More

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http://dx.doi.org/10.1097/MD.0000000000017087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750291PMC
September 2019
7 Reads

Sexually Transmitted Infections: Prevention, Diagnosis, and Treatment in Primary Care.

Pediatr Ann 2019 Sep;48(9):e370-e375

Most adolescents are cared for by general pediatricians, family practitioners, and mid-level providers. As a result, primary care practitioners need to be prepared to answer questions from adolescent patients and their parents about sexually transmitted infections (STIs), to practice good preventive medicine through screening and vaccination, and to provide treatment of STIs when needed. Although the topic of STIs is broad, there are common scenarios that arise in adolescent care. Read More

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https://www.healio.com/doiresolver?doi=10.3928/19382359-2019
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http://dx.doi.org/10.3928/19382359-20190815-02DOI Listing
September 2019
5 Reads

Host-Pathogen Interactions during Female Genital Tract Infections.

Trends Microbiol 2019 12 23;27(12):982-996. Epub 2019 Aug 23.

Department of Microbial Pathogenicity Mechanisms, Hans Knoell Institute, Jena, Germany; Institute of Microbiology, Friedrich Schiller University, Jena, Germany. Electronic address:

Dysbiosis in the female genital tract (FGT) is characterized by the overgrowth of pathogenic bacterial, fungal, or protozoan members of the microbiota, leading to symptomatic or asymptomatic infections. In this review, we discuss recent advances in studies dealing with molecular mechanisms of pathogenicity factors of Gardnerella vaginalis, Mycoplasma genitalium, Mycoplasma hominis, Neisseria gonorrhoeae, Streptococcus agalactiae, Chlamydia trachomatis, Trichomonas vaginalis, and Candida spp., as well as their interactions with the host and microbiota in the various niches of the FGT. Read More

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http://dx.doi.org/10.1016/j.tim.2019.07.006DOI Listing
December 2019
4 Reads

Ki-67 and P16 proteins in cervical cancer and precancerous lesions of young women and the diagnostic value for cervical cancer and precancerous lesions.

Oncol Lett 2019 Aug 3;18(2):1351-1355. Epub 2019 Jun 3.

Department of Obstetrics and Gynecology, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, P.R. China.

Expression of Ki-67 and P16 proteins in cervical cancer and precancerous lesions of young women and the diagnostic value for cervical cancer and precancerous lesions were investigated. A total of 64 paraffin-embedded specimens of uterus tissue from young female patients who were admitted to Jiading District Central Hospital Affiliated to Shanghai University of Medicine and Health Sciences from January 2015 to December 2017 were selected. According to pathological examination, the specimens were divided into chronic cervicitis group (control group, 10 cases), low-grade squamous intraepithelial lesion (LSIL) group (12 cases), high-grade squamous intraepithelial lesion (HSIL) group (20 cases) and squamous carcinoma of the cervix (SCC) group (22 cases). Read More

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http://dx.doi.org/10.3892/ol.2019.10430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607340PMC
August 2019
5 Reads

Amebic Infection of the Female Genital Tract: A Report of Three Cases.

J Midlife Health 2019 Apr-Jun;10(2):96-98

Department of Radiation Oncology, American Oncology Institute, Hyderabad, Telangana, India.

Amebiasis is a common protozoan disease with a worldwide distribution. It is endemic in tropical developing countries, and cases are being detected in subtropical countries as well. It usually presents with intestinal manifestations. Read More

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http://dx.doi.org/10.4103/jmh.JMH_152_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643709PMC
August 2019
7 Reads

An update on prevalence, diagnosis, treatment and emerging issues of genital mycoplasma infection in Indian women: A narrative review.

Indian J Dermatol Venereol Leprol 2019 Sep-Oct;85(5):441-447

Department of Clinical Research, ICMR-National Institute for Research in Reproductive Health, Mumbai, Maharashtra, India.

Despite adequate treatment of reproductive tract infection, there is persistence of symptoms in some patients. This raises the possibility of existence of other silent microbes with pathogenic potential. Apart from the common sexually transmitted organisms such as Chlamydia trachomatis and Neisseria gonorrhoeae, there are other silent and emerging pathogens, like genital mycoplasma, which have been associated with cervicitis, pelvic inflammatory disease, infertility, and pregnancy-related complications in women. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_915_18DOI Listing
May 2020
3 Reads

[Relationship between cervical lesions and the type-specific viral load of high risk HPV reflected by the Ct value of Cobas 4800 HPV system].

Zhonghua Fu Chan Ke Za Zhi 2019 Jul;54(7):458-463

Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecological Diseases, Shenzhen 518036, China.

To explore the relationship between cervical lesions and high risk HPV (HR-HPV) viral load reflected by the cycle threshold (Ct) values of Cobas 4800 HPV (Cobas 4800) system. From August 2016 to September 2017, 7 000 women from Shenzhen, were recruited for cervical cancer screening with Cobas 4800 system and cytology co-test. Colposcope biopsies were performed on women who were positive of HPV 16, 18, and positive of HPV types other than 16,18 with cytology [≥ atypical squamous cell of undetermined signification (ASCUS)], or HPV negative but abnormal of cytology [≥ low grade squamous intraepithelial lesion (LSIL)]. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2019.07.005DOI Listing
July 2019
5 Reads

Association of TLR4 and TLR9 gene polymorphisms and haplotypes with cervicitis susceptibility.

PLoS One 2019 31;14(7):e0220330. Epub 2019 Jul 31.

P D Patel Institute of Applied Sciences, Charotar University of Science and Technology (CHARUSAT), Changa, Anand, India.

Background: Cervicitis is one of the major health problems amongst women caused by infection of various pathogens including Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Trichomonas vaginalis (TV) as well as human papillomavirus (HPV), and persistent cervical inflammation is one of the etiologic agents of cervical cancer. Toll-like receptors (TLRs) play an important role in the recognition and subsequent elimination of these pathogens. Variations in the Toll-like receptor genes influence susceptibility to pathogens as well as disease progression independently. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0220330PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668796PMC
March 2020
9 Reads
3.234 Impact Factor

Cryotherapy as a Method for Relieving Symptoms of Cervical Ectopy: A Randomized Clinical Trial.

Oman Med J 2019 Jul;34(4):322-326

Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.

Objectives: Benign cervical ectopy (CE) may cause chronic or recurrent symptoms leading to women repeatedly being referred to gynecology clinics. We aimed to present a safe and effective method for relieving symptoms of CE.

Methods: This double-blind clinical trial was conducted among 164 women with CE who complained of persistent or recurrent symptoms of cervicitis in the last six months. Read More

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http://dx.doi.org/10.5001/omj.2019.63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642705PMC
July 2019
13 Reads

Comparison of the AV Magnivisualizer device with colposcopy to detect cervical intraepithelial neoplasia using the Swede scoring system.

Int J Gynaecol Obstet 2019 Nov 13;147(2):219-224. Epub 2019 Aug 13.

National Institute of Cancer Prevention and Research, Noida, India.

Objective: To compare the AV Magnivisualizer with colposcopy to detect cervical intraepithelial neoplasia (CIN) using the Swede scoring system.

Methods: Cross-sectional study conducted in a tertiary care hospital from May 2017 to March 2018. One hundred women with positive results at visual inspection with acetic acid underwent cervical inspection using the Magnivisualizer followed by a colposcope. Read More

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http://dx.doi.org/10.1002/ijgo.12931DOI Listing
November 2019
7 Reads
1.563 Impact Factor

Comparable expression of miR-let-7b, miR-21, miR-182, miR-145, and p53 in serum and cervical cells: Diagnostic implications for early detection of cervical lesions.

Int J Health Sci (Qassim) 2019 Jul-Aug;13(4):29-38

Department of Family Medicine, State Hospital Ijaiye, Abeokuta, Ogun State, Nigeria.

Objective: The high mortality associated with cervical cancer is due to low uptake of Pap smear test, lack of early diagnostic biomarkers and less-invasive approach, and late presentation of the disease. This study evaluated the expression of hsa-miR-let-7b, hsa-miR-21, hsa-miR-125b, hsa-miR-143, hsa-miR-145, hsa-miR-146a, hsa-miR-155, hsa-miR-182, hsa-miR-200c, and p53 in serum and cervix in relation to classes of Pap smear, in a bid to identify a serum panel for early diagnosis of cervical lesions.

Methodology: This study included 329 women; 159 healthy women (HW), 46 cervicitis, 46 atypical squamous cells of undetermined significance (ASCUS), 40 low-grade squamous cell intraepithelial lesion (LSIL), 28 high-grade squamous cell intraepithelial lesion (HSIL), and 10 squamous cell carcinoma (SCC). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619463PMC
July 2019
3 Reads

: A Review.

Microbiology 2020 01;166(1):21-29

National Infection Service, Public Health England, 61 Colindale Avenue, London NW9 5EQ, UK.

is a fastidious organism of the class the smallest prokaryote capable of independent replication. First isolated in 1981, much is still unknown regarding its natural history in untreated infection. It is recognized as a sexually transmitted pathogen causing acute and chronic non-gonococcal urethritis (NGU) in men, with a growing body of evidence to suggest it also causes cervicitis and pelvic inflammatory disease in women. Read More

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http://dx.doi.org/10.1099/mic.0.000830DOI Listing
January 2020
10 Reads

ULTRASOUND DIAGNOSTICS OF CERVICAL CHANGES WITH DIFFERENT LOCALIZATION OF THE CERVICITIS IN WOMEN WITH THE ECTOPY OF THE VAGINAL PORTION OF THE CERVIX.

Georgian Med News 2019 May(290):32-37

2Dnipropetrovsk Medical Academy, Ukraine.

The aim of the study was to improve the diagnosis of structural changes in all parts of the cervix depending on the preferential localization of the inflammatory process - in the ectocervix, endocervix, and also in the stroma in women with ectopia (pseudoerosis) of the vaginal part of the cervix. The study included women of predominantly early and middle reproductive age, as these women have inflammatory processes more often than in menopause. To perform the work, a transvaginal imaging method was used, which allowed us to see the smallest structures (up to 0. Read More

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May 2019
4 Reads

New serum biomarker identification and analysis by mass spectrometry in cervical precancerous lesion and acute cervicitis in South China.

Cancer Manag Res 2019 4;11:6151-6162. Epub 2019 Jul 4.

Department of General Practice Center, Nanhai Hospital, Southern Medical University, Foshan, Guangdong 528244, People's Republic of China.

According to the statistics of WHO/IARC, cervical cancer (CC) has become the fourth malignant cancer of female worldwide and it is one of the main causes of death of women in developing countries. Potential plasma and metabolic biomarkers for CC precancerous lesions and cervicitis were indicated by LC-MS techniques, and their underlying mechanisms and functions were analyzed. Plasma samples were selected from healthy people (control), low-grade squamous intraepithelial lesions (LSIL), high-grade squamous intraepithelial lesions (HSIL), CC, and post-treatment patients. Read More

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http://dx.doi.org/10.2147/CMAR.S205052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613603PMC
July 2019
10 Reads

The value of cytokine levels in triage and risk prediction for women with persistent high-risk human papilloma virus infection of the cervix.

Infect Agent Cancer 2019 28;14:16. Epub 2019 Jun 28.

1Tianjin Central Hospital of Gynecology and Obstetrics, No. 156, Nankaisan Road, Nankai District, Tianjin, China.

Background: Cervical cancer is a common cancer among women worldwide and is closely related to high-risk human papillomavirus infection (HR-HPV). The immune microenvironment is thought to play an essential role in viral infection and cancer development; however, this relationship remains controversial. Cytokines are an important part of the immune system. Read More

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http://dx.doi.org/10.1186/s13027-019-0231-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599292PMC
June 2019
4 Reads
2.071 Impact Factor

Characterization of DNA hydroxymethylation profile in cervical cancer.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):2706-2714

a Department of Gynecology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University , Yantai , Shandong , People's Republic of China.

Cervical cancer is one of the most common gynecological tumors in females. DNA methylation alteration is a type of epigenetic decoration that controls the gene transcriptional regulation and is essential for the pathological progression of cervical cancer to reflect the prognosis and therapeutic sensitivity in clinical practice. Beyond DNA methylation, DNA hydroxymethylation considered as a more stable biomarker draws the outline of the reversible cycle from DNA methylation and demethylation. Read More

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https://www.tandfonline.com/doi/full/10.1080/21691401.2019.1
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http://dx.doi.org/10.1080/21691401.2019.1634578DOI Listing
December 2019
4 Reads