3,370 results match your criteria Cervicitis


Prevalence of human papillomavirus among Wenzhou women diagnosed with cervical intraepithelial neoplasia and cervical cancer.

Infect Agent Cancer 2018 26;13:37. Epub 2018 Nov 26.

Department of Pathology, Wenzhou People's Hospital, The third Clinical Institute Affiliated to Wenzhou Medical University, 299 Guan Rd. Ouhai district, Wenzhou, Zhejiang, China.

Background: Human papillomavirus (HPV) is associated with an increased risk of cervical cancer. Using a vaccine to prevent HPV infections could be a cost-effective strategy to decrease the incidence of cervical cancer. Learning about the characteristics of CIN patients with HPV infection in Wenzhou is a key step in guiding the use of HPV vaccines and screening for cervical cancer. Read More

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November 2018

[Paraffin section thickness in immunohistochemical detection of p16 expression in cervical tissue samples].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2018 Feb;47(4):362-366

Department of Pathology, Zhongshan Boai Hospital Affiliated to Southern Medical University, Zhongshan 528400, Guangdong Province, China.

Objective: To investigate paraffin section thickness in immunohistochemical detection of p16 expression in cervical tissue samples.

Methods: p16 immunohistochemical staining was performed in 150 cases of chronic cervicitis, 126 cases of low-grade squamous intraepithelial lesions(LSIL), 96 cases of high-grade squamous intraepithelial lesions (HSIL) and 78 cases of cervical cancer from January 2014 to March 2018 in Zhongshan Boai Hospital. The results of p16 protein expression in paraffin sections with thickness of 2, 3, 4, 5 and 6 μm were compared using Logistic regression analysis. Read More

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February 2018

[Value of combined detection of claudin 4 and high-risk human papilloma virus in high-grade squamous intraepithelial lesion and cervix squamous cell carcinoma].

Authors:
Chenhong Di Fan Jin

Zhejiang Da Xue Xue Bao Yi Xue Ban 2018 Feb;47(4):344-350

Department of Reproductive Genetics, Women's Hospital, Zhejiang University School of Medicine, Key Laboratory of Reproductive Genetics, Ministry of Education, Hangzhou 310006, China.

Objective: To investigate the expression of claudin 4 (CLDN4) in cervical tissues from patients with different cervical lesions, and to explore the value of combined detection of CLDN4 and high risk human papilloma virus (HR-HPV).

Methods: The cervical tissue specimens of low-grade squamous intraepithelial lesion (LSIL, =30), high-grade squamous intraepithelial lesion (HSIL, =30), squamous cell carcinoma (SCC, =30) as well as chronic cervicitis (control, =30) were collected from the Sir Run Run Shaw Hospital of Zhejiang University during June 2015 and December 2016. The expression of CLDN4 protein in tissue specimens was detected by immunohistochemistry, HR-HPV was detected by real-time quantitative PCR, and the cervical exfoliated cells were examined by thinprep cytologic test (TCT). Read More

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February 2018

Human papillomaviruses 16 and 58 are distributed widely among women living in Shanghai, China, with high-grade, squamous intraepithelial lesions.

Epidemiol Infect 2018 Nov 13:1-6. Epub 2018 Nov 13.

Department of Obstetrics and Gynecology,Minhang Hospital, Fudan University,170 Xinsong Road, Minhang District, Shanghai 201199,P.R. China.

The distribution of human papillomaviruses (HPVs) must be understood for the control and prevention of cervical cancer. Community-based Papanicolaou and HPV DNA tests were performed on 41 578 women. The prevalences of HPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68 were assessed. Read More

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November 2018
4 Reads

Analysis of cervical human papillomavirus infection in 2300 women in Urumqi, China.

Medicine (Baltimore) 2018 Nov;97(45):e13206

Department of Obstetrics and Gynecology, Dongfang Hospital of Tongji University, Shanghai, China.

This study is to investigate the cervical human papillomavirus (HPV) infection rate in women of Urumqi, China.The epidemiological questionnaire survey was used to study 2300 women in Urumqi with a prospective research method. The second-generation hybrid capture assay, cervical liquid-based cytology test, colposcopy, and cervical biopsy were used to screen CC. Read More

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November 2018
1 Read

Human papillomavirus DNA, HPV L1 capsid protein and p16 protein as markers to predict cervical lesion progression.

Arch Gynecol Obstet 2018 Nov 2. Epub 2018 Nov 2.

Department of Gynaecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 201240, China.

Objectives: Cervical cancer is the most common malignant tumors in women leading to serious morbidity and mortality worldwide, especially among developing countries. A main cause of the disease is the high-risk human papillomavirus (HR-HPV) infection. HSIL usually progress to cervical cancer, and low-grade lesions, including LSIL and ASCUS, mostly turn to normal or benign lesions, but there are still a small number of patients who will progress to HSIL. Read More

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November 2018
5 Reads

[Relationship of Toll Like Receptors Expression and HPV16 Infection in Cervical Squamous Cell Cancer].

Sichuan Da Xue Xue Bao Yi Xue Ban 2018 Jul;49(4):649-651

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China.

Objective: To analyze the relationship between Toll like receptors () mRNA expression levels and HPV16 infection in cervical squamous cell cancer (SCC).

Methods: Expression levels of mRNA and HPV16 in tissue samples collected from cervical squamous carcinoma and cervicitis were detected, and the relationship of mRNA expression and HPV infection was analyzed in two different disease groups.

Results: Expressions of mRNA were not related to HPV16 infection in cervical squamous cell cancer. Read More

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July 2018
4 Reads

[Current diagnosis and treatment of sexually transmitted infections].

Urologe A 2018 Dec;57(12):1436-1444

Klinik für Urologie, Kinderurologie und Andrologie, Justus-Liebig-Universität Gießen, Rudolf-Buchheim-Str. 7, 35392, Gießen, Deutschland.

Background: In recent years, there has been an increasing incidence of sexually transmitted infections (STI), which in turn play a major role in urological clinical routine.

Objectives: Which STIs are relevant in urological clinical routine? What kind of recommendations for diagnosis and treatment exist?

Materials And Methods: Review of evidence-based recommendations from the literature, current guidelines of the European Association of Urology and the Robert-Koch-Institute.

Results: STIs can be differentiated into those that cause genital, anal, perianal or oral ulcers from STIs that cause urethritis, cervicitis, or urethral or vaginal discharge. Read More

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December 2018
1 Read

Mycoplasma genitalium Infections in Women Attending a Sexually Transmitted Disease Clinic in New Orleans.

Clin Infect Dis 2018 Oct 23. Epub 2018 Oct 23.

Department of Medicine, Section of Infectious Diseases, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, USA.

Background: Several studies have reported statistically significant associations of Mycoplasma genitalium with cervicitis, urethritis, or vaginal discharge, although non-significant associations have also been reported. This study examined the associations of M. genitalium with selected sexually transmitted infections (STIs), demographic, behavioral, and clinical factors among women attending a sexually transmitted disease (STD) clinic in New Orleans. Read More

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October 2018
1 Read

Analysis of gene mutation associated with tyrosine kinase inhibitor sensitivity of epidermal growth factor receptor in cervical cancer patients.

Eur Rev Med Pharmacol Sci 2018 Oct;22(19):6280-6287

Department of Obstetrics and Gynecology, The First Clinical Medicine College of Yangtze University, Jingzhou, Hubei, China.

Objective: Cervical cancer is frequent in females. Epidermal growth factor receptor has a prominent expression in certain malignant tumors. This study aims to observe the expressional profile of epidermal growth factor receptor (EGFR) in cervical cancer patients, and mutation of EGFR gene related with its sensitivity towards tyrosine kinase inhibitor. Read More

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October 2018
2 Reads

Prevalence characteristics of single and multiple HPV infections in women with cervical cancer and precancerous lesions in Beijing, China.

J Med Virol 2018 Oct 3. Epub 2018 Oct 3.

Department of Gynecology and Obstetrics, People's Liberation Army (PLA) Medical School, Chinese PLA General Hospital, Beijing, China.

We assessed the prevalence characteristics of single and multiple high-risk human papillomavirus (HR-HPV) infections. A total of 1783 women who underwent colposcopy and cervical biopsy for abnormal ThinPrep Cytology Test and/or HR-HPV subtype genotyping results were enrolled in the study. Among the participants, 770 were diagnosed with cervicitis, 395 with cervical intraepithelial neoplasia grade 1 (CIN1), 542 with CIN2-3, and 76 with squamous cell carcinoma (SCC), with HR-HPV infection rates of 75. Read More

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October 2018
2 Reads

Clinical Value of Human Papillomavirus E6/E7 mRNA Detection in Screening for Cervical Cancer in Women Positive for Human Papillomavirus DNA or.

Clin Lab 2018 Sep;64(9):1363-1371

Background: The detection of human papillomavirus (HPV) E6/E7 mRNA indicates a risk of further deterioration in cervical lesions. We explored the clinical value of HPV E6/E7 mRNA detection in cervical cancer screening in women positive for HPV or with abnormal thin-prep cytology test (TCT) results in the Xinjiang region of China.

Methods: A total of 6,800 women were screened in our hospital for cervical cancer by both TCT and HPV DNA testing from August 2013 to June 2015. Read More

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September 2018
1 Read

The Additive Value of Pelvic Examinations to History in Predicting Sexually Transmitted Infections for Young Female Patients With Suspected Cervicitis or Pelvic Inflammatory Disease.

Ann Emerg Med 2018 Dec 2;72(6):703-712.e1. Epub 2018 Jul 2.

Department of Emergency Medicine, Newark Beth Israel Medical Center, Newark, NJ; Children's Hospital of New Jersey, Newark, NJ. Electronic address:

Study Objective: We evaluate the additive value of pelvic examinations in predicting sexually transmitted infection for young female patients with suspected cervicitis or pelvic inflammatory disease in a pediatric emergency department (ED).

Methods: This was a prospective observational study of female patients aged 14 to 20 years who presented to an urban academic pediatric ED with a complaint of vaginal discharge or lower abdominal pain. Enrolled patients provided a urine sample for chlamydia, gonorrhea, and trichomonas testing, which served as the criterion standard for diagnosis. Read More

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December 2018
1 Read

Efficacy and safety of combined high-dose interferon and red light therapy for the treatment of human papillomavirus and associated vaginitis and cervicitis: A prospective and randomized clinical study.

Medicine (Baltimore) 2018 Sep;97(37):e12398

Department of Dermatovenereology, Ningxia Yangguang Hospital, Yinchuan, China.

Background: We evaluated the efficacy and safety of combined high-dose interferon (IFN) and red light therapy for the treatment of subclinical and latent human papillomavirus (HPV) infections.

Methods: Ninety women diagnosed with subclinical or latent HPV infection were randomized to receive topical application of low-dose recombinant IFNα-2b (1 million IU), high-dose IFNα-2b (9 million IU), or a combination of high-dose IFNα-2b and red light therapy on the cervix and vagina. All patients received treatment once daily for 4 weeks. Read More

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September 2018
1 Read

The Role of Polymorphonuclear Leukocyte Counts from Urethra, Cervix, and Vaginal Wet Mount in Diagnosis of Nongonococcal Lower Genital Tract Infection.

Infect Dis Obstet Gynecol 2018 26;2018:8236575. Epub 2018 Jul 26.

Oslo University Hospital, Department of Venereology, The Olafia Clinic, Norwegian National Advisory Unit on Sexually Transmitted Infections, Oslo, Norway.

Objective: The aim of this study was to evaluate whether the polymorphonuclear leukocyte (PMNL) inflammatory response in women with nongonococcal lower genital tract infection (LGTI) can be used to optimize criteria for syndromic treatment.

Methods: A cross-sectional study of 375 women attending the STI clinic in Oslo. Urethral, cervical, and vaginal specimens underwent microscopy for PMNLs. Read More

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July 2018
4 Reads

PP2A Inhibits Cervical Cancer Cell Migration by Dephosphorylation of p-JNK, p-p38 and the p-ERK/MAPK Signaling Pathway.

Curr Med Sci 2018 Feb 15;38(1):115-123. Epub 2018 Mar 15.

Department of Clinical Laboratory, Wuhan, 430060, China.

Protein phosphatase 2A (PP2A) was reported to play an important role in cancer development; however, the relationship between PP2A and cervical cancer development has yet to be fully understood. The present study aimed to explore the role of PP2A in the development of cervical cancer. Serum levels of PP2A were detected by ELISA in 23 patients with cervical cancer and 30 patients with benign cervical lesions. Read More

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February 2018
2 Reads

2018 European (IUSTI/WHO) International Union against sexually transmitted infections (IUSTI) World Health Organisation (WHO) guideline on the management of vaginal discharge.

Int J STD AIDS 2018 Nov 27;29(13):1258-1272. Epub 2018 Jul 27.

5 Research Unit for Reproductive Microbiology, Statens Serum Institut, Copenhagen, Denmark.

Four common pathological conditions are associated with vaginal discharge: bacterial vaginosis, aerobic vaginitis, candidosis, and the sexually transmitted infection, trichomoniasis. Chlamydial or gonococcal cervical infection may result in vaginal discharge. Vaginal discharge may be caused by a range of other physiological and pathological conditions including atrophic vaginitis, desquamative inflammatory vaginitis, cervicitis, and mucoid ectopy. Read More

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November 2018
27 Reads

B lymphocytes can be activated to act as antigen presenting cells to promote anti-tumor responses.

PLoS One 2018 5;13(7):e0199034. Epub 2018 Jul 5.

Department of Immunology, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.

Immune evasion by tumors includes several different mechanisms, including the inefficiency of antigen presenting cells (APCs) to trigger anti-tumor T cell responses. B lymphocytes may display a pro-tumoral role but can also be modulated to function as antigen presenting cells to T lymphocytes, capable of triggering anti-cancer immune responses. While dendritic cells, DCs, are the best APC population to activate naive T cells, DCs or their precursors, monocytes, are frequently modulated by tumors, displaying a tolerogenic phenotype in cancer patients. Read More

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July 2018
9 Reads

Ureaplasma urealyticum: the Role as a Pathogen in Women's Health, a Systematic Review.

Curr Infect Dis Rep 2018 Jun 29;20(9):33. Epub 2018 Jun 29.

Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Hebrew University, Jerusalem, Israel.

Purpose Of Review: To evaluate the role of Ureaplasma urealyticum as a genital pathogen in women's health. Three aspects were analyzed: (1) preterm delivery (PTD); (2) female infertility; and (3) lower genital tract pathology including pelvic inflammatory disease (PID), cervicitis, and genital discomfort (discharge, burning).

Recent Findings: A systematic review was performed. Read More

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June 2018
31 Reads

Transcriptome Analysis of Neisseria gonorrhoeae during Natural Infection Reveals Differential Expression of Antibiotic Resistance Determinants between Men and Women.

mSphere 2018 08 27;3(3). Epub 2018 Jun 27.

Department of Immunology, Tufts University School of Medicine, Boston, Massachusetts, USA

is a bacterial pathogen responsible for the sexually transmitted infection gonorrhea. Emergence of antimicrobial resistance (AMR) of worldwide has resulted in limited therapeutic choices for this infection. Men who seek treatment often have symptomatic urethritis; in contrast, gonococcal cervicitis in women is usually minimally symptomatic, but may progress to pelvic inflammatory disease. Read More

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August 2018
13 Reads
1 Citation

Sipi soup inhibits cancer‑associated fibroblast activation and the inflammatory process by downregulating long non‑coding RNA HIPK1‑AS.

Mol Med Rep 2018 Aug 6;18(2):1361-1368. Epub 2018 Jun 6.

Department of Acupuncture and Moxibustion, Longyan First Hospital, Longyan, Fujian 364000, P.R. China.

Sipi soup (SPS), the aqueous extract derived from the root bark of Sophora japonical L, Salix babylonica L., Morus alba L., as well as Amygdalus davidiana (Carr. Read More

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August 2018
1 Read

A prospective pilot evaluation of vaginal and urine self-sampling for the Roche cobas 4800 HPV test for cervical cancer screening.

Sci Rep 2018 Jun 13;8(1):9015. Epub 2018 Jun 13.

National Cancer Control Institute, National Cancer Center, Goyang, 10408, Republic of Korea.

This pilot study sought to evaluate the feasibility of utilizing vaginal self-swabs and urine samples for HPV-based cervical cancer screening in 700 women who had undergone conventional Pap smear screening via the national cervical cancer program in Korea. The cobas 4800 HPV test was utilized to detect HPV in the self-samples. Pap smear results revealed three cases of atypical squamous cells of undetermined significance, 649 cases of negative for an intraepithelial lesion or malignancy, and 48 non-specific inflammatory findings. Read More

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June 2018
1 Read
5.080 Impact Factor

Applications of genomics to slow the spread of multidrug-resistant Neisseria gonorrhoeae.

Ann N Y Acad Sci 2018 Jun 6. Epub 2018 Jun 6.

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

Infections with Neisseria gonorrhoeae, a sexually transmitted pathogen that causes urethritis, cervicitis, and more severe complications, are increasing. Gonorrhea is typically treated with antibiotics; however, N. gonorrhoeae has rapidly acquired resistance to many antibiotic classes, and lineages with reduced susceptibility to the currently recommended therapies are emerging worldwide. Read More

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June 2018
3 Reads

Outcomes of resistance-guided sequential treatment of Mycoplasma genitalium infections: a prospective evaluation.

Clin Infect Dis 2018 Jun 5. Epub 2018 Jun 5.

Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.

Background: Rising macrolide and quinolone resistance in Mycoplasma genitalium necessitate new treatment approaches. We evaluated outcomes of sequential antimicrobial therapy for M.genitalium guided by a macrolide-resistance assay. Read More

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June 2018
3 Reads

BLT1-mediated O-GlcNAcylation is required for NOX2-dependent migration, exocytotic degranulation and IL-8 release of human mast cell induced by Trichomonas vaginalis-secreted LTB.

Microbes Infect 2018 Jun - Jul;20(6):376-384. Epub 2018 May 31.

Department of Environmental Medical Biology, Institute of Tropical Medicine, South Korea; Yonsei University College of Medicine, Seoul 120-752, South Korea. Electronic address:

Trichomonas vaginalis is a sexually-transmitted protozoan parasite that causes vaginitis and cervicitis. Although mast cell activation is important for provoking tissue inflammation during infection with parasites, information regarding the signaling mechanisms in mast cell activation and T. vaginalis infection is limited. Read More

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May 2018
3 Reads

Expression of AMHR2 and C-KIT in cervical lesions in Uyghur Women of Xinjiang, China.

Medicine (Baltimore) 2018 Jun;97(22):e10793

Department of Histology and Embryology.

Background: Cervical cancer is one of the most common malignant tumors in women. Anti-Müllerian hormone receptor 2 (AMHR2) and C-Kit were two members of protein kinase which were reported increased in some cancers like ovarian carcinoma and breast cancer. The present study aimed to assess the expression of AMHR2 and c-Kit in cervical cancer of different differentiated degrees as well as in cervicitis sections. Read More

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June 2018
11 Reads

Common Sexually Transmitted Infections in Women.

Nurs Clin North Am 2018 Jun;53(2):189-202

Department of Family, Community, and Health Systems, University of Alabama at Birmingham School of Nursing, 1701 University Boulevard, Birmingham, AL 35294-1210, USA.

The spread of sexually transmitted infections (STIs) remains a significant public health issue in the United States. Social, economic, and behavioral implications affecting the spread of STIs have been identified. The most important social factor in the United States is the stigma associated with discussing sex and STI screening. Read More

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June 2018
16 Reads

An integrative investigation of the therapeutic mechanism of Ainsliaea fragrans Champ. in cervicitis using liquid chromatography tandem mass spectrometry based on a rat plasma metabolomics strategy.

J Pharm Biomed Anal 2018 Jul 27;156:221-231. Epub 2018 Apr 27.

Jiangxi University of Traditional Chinese Medicine, No. 818 Yunwan Road, Nanchang 330002, PR China; State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, No. 56 Yangming Road, Nanchang 330006, PR China. Electronic address:

Cervicitis is an extremely common gynecological disease and can be induced by diverse factors such as Neisseria gonorrhoeae, Chlamydia trachomatis, and Mycoplasma genitalium infections. Long-term unhealed cervicitis may lead to a series of diseases including endometritis, salpingitis, pelvic inflammatory disease, and chorioamnionitis. However, the pathogenesis of cervicitis remains unknown. Read More

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July 2018
13 Reads

Comparative Metabolomics Analysis of Cervicitis in Human Patients and a Phenol Mucilage-Induced Rat Model Using Liquid Chromatography Tandem Mass Spectrometry.

Front Pharmacol 2018 4;9:282. Epub 2018 Apr 4.

Jiangxi University of Traditional Chinese Medicine, Nanchang, China.

Cervicitis is an exceedingly common gynecological disorder that puts women at high risk of sexually transmitted infections and induces a series of reproductive system diseases. This condition also has a significant impact on quality of life and is commonly misdiagnosed in clinical practice due to its complicated pathogenesis. In the present study, we performed non-targeted plasma metabolomics analysis of cervicitis in both plasma samples obtained from human patients and plasma samples from a phenol mucilage induced rat model of cervicitis, using ultra-performance liquid chromatography coupled to quadrupole time-of-flight tandem mass spectrometry. Read More

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April 2018
4 Reads

Assessing prevalence of missed laboratory-confirmed sexually transmitted infections among women in Kingston, Jamaica: results from a secondary analysis of the Sino-Implant clinical trial.

BMJ Open 2018 04 13;8(4):e019913. Epub 2018 Apr 13.

Division of Reproductive Health, U.S. Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.

Objectives: To assess potentially missed sexually transmitted infections (STIs), we compared clinically diagnosed STIs to laboratory-confirmed diagnoses of gonorrhoea (GC), chlamydia (CT) and trichomonas (Tvag).

Design: Secondary analysis of a randomised controlled trial.

Setting: We used data and specimens previously collected for the Sino-Implant Study in Kingston, Jamaica. Read More

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April 2018
8 Reads

Prevalence of and other sexually-transmitted pathogens among high-risk individuals in Greece.

Germs 2018 Mar 1;8(1):12-20. Epub 2018 Mar 1.

MD, PhD, FRCPath, Department of Microbiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Background: The aim of the present study was to determine the prevalence of (MG) infection among individuals at high risk for sexually-transmitted diseases (STDs) at a major urban STD clinic in Athens, in view of the lack of data pertaining to this infection in Greece.

Methods: Urethral and cervical samples from 176 individuals consecutively attending the clinic and agreeing to participate were prospectively collected and tested for MG infection using conventional PCR and TaqMan Real-Time PCR. All individuals were also examined for alternative STD pathogens. Read More

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March 2018
1 Read

[Prevalence and phylogenetic analysis of Chlamydia trachomatis in a population of women in Posadas, Misiones].

Rev Esp Quimioter 2018 Feb 16;31(1):21-26. Epub 2017 Feb 16.

Graciela Beatriz Jordá, Cátedra de Virología, Facultad de Ciencias Exactas, Químicas y Naturales, Universidad Nacional de Misiones. Luis Pasteur 1551. CP: 3300. Posadas, Misiones, Argentina.

Objective: Chlamydia trachomatis is the most prevalent bacteria causing sexually transmitted infections. In women, this infection can cause cervicitis and urethritis, although it's usually asymptomatic. The aim of this study was to investigate the prevalence of C. Read More

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February 2018
2 Reads

Prevalence of in different population groups: systematic review andmeta-analysis.

Sex Transm Infect 2018 06 9;94(4):255-262. Epub 2018 Feb 9.

Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.

Background: is a common cause of non-gonococcal non-chlamydial urethritis and cervicitis. Testing of asymptomatic populations has been proposed, but prevalence in asymptomatic populations is not well established. We aimed to estimate the prevalence of in the general population, pregnant women, men who have sex with men (MSM), commercial sex workers (CSWs) and clinic-based samples, METHODS: We searched Embase, Medline, IndMED, African Index Medicus and LILACS from 1 January 1991 to 12 July 2016 without language restrictions. Read More

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June 2018
8 Reads
3.400 Impact Factor

Ligneous cervicitis and endometritis: A gynaecological presentation of congenital plasminogen deficiency.

Haemophilia 2018 May 13;24(3):359-365. Epub 2018 Feb 13.

Department of Obstetrics and Gynaecology, The Royal Free Foundation NHS Trust, London, UK.

Background: Congenital plasminogen deficiency is a rare autosomal recessive condition. Plasminogen deficiency is thought to result in an inability of fibrin breakdown and therefore accumulation of fibrin and formation of ligneous changes. Ligneous lesions can form on a number of mucosal membranes including the cervix and endometrium. Read More

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May 2018
13 Reads
2.600 Impact Factor

Future of human Chlamydia vaccine: potential of self-adjuvanting biodegradable nanoparticles as safe vaccine delivery vehicles.

Expert Rev Vaccines 2018 03 6;17(3):217-227. Epub 2018 Feb 6.

a Department of Biological Sciences , Alabama State University , Montgomery , AL , USA.

Introduction: There is a persisting global burden and considerable public health challenge by the plethora of ocular, genital and respiratory diseases caused by members of the Gram-negative bacteria of the genus Chlamydia. The major diseases are conjunctivitis and blinding trachoma, non-gonococcal urethritis, cervicitis, pelvic inflammatory disease, ectopic pregnancy, tubal factor infertility, and interstitial pneumonia. The failures in screening and other prevention programs led to the current medical opinion that an efficacious prophylactic vaccine is the best approach to protect humans from chlamydial infections. Read More

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March 2018
10 Reads

Association between visual inspection of the cervix with acetic acid examination and high-risk human papillomavirus infection, Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis in Papua New Guinea.

Aust N Z J Obstet Gynaecol 2018 Oct 30;58(5):576-581. Epub 2018 Jan 30.

The Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.

Background: Papua New Guinea (PNG) has among the highest estimated burdens of cervical cancer globally but currently has no national cervical screening program. Visual inspection of the cervix with acetic acid (VIA) is a low-cost screening strategy endorsed by the World Health Organization that has been adopted in many low-resource settings but not previously evaluated in PNG.

Aim: To evaluate the association between VIA examination findings and high-risk HPV (hrHPV) infection; and the impact of concomitant genital Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis on the interpretation of VIA findings. Read More

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October 2018
10 Reads

Identifying acute cervicitis in an era of less-frequent routine gynecologic examinations.

Authors:
Margaret Allen

JAAPA 2018 Feb;31(2):50-53

Margaret Allen is a former PA program director for the University of Worcester in the United Kingdom, former clinical instructor in the Stanford University primary care associate program, and practiced family medicine at Ravenswood Family Health Center in East Palo Alto, Calif. The author has disclosed no potential conflicts of interest, financial or otherwise.

Acute inflammation of the uterine cervix can lead to serious problems such as pelvic inflammatory disease (PID), endometritis, and complications of pregnancy and childbirth. As intervals for routine gynecologic screening examinations lengthen, cervical infections, especially if asymptomatic, may be missed. Annual wellness examinations and other patient visits outside routine gynecologic cancer screening visits should include brief evaluation with sexual risk assessment and a gynecologic examination if indicated. Read More

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February 2018
3 Reads

Effect of Dialyzable Leukocyte Extract on chronic cervicitis in patients with HPV infection.

J Med Life 2017 Oct-Dec;10(4):237-243

PLaboratory of Molecular Biomedicine I, ENMyH, Instituto Politécnico Nacional, Mexico.

The objective of the study was to assess the clinical, histopathological and immunochemical changes induced by dialyzable leukocyte extract (DLE) treatment in patients with chronic cervicitis associated to HPV infection. Fifty-four female Mexican patients diagnosed with chronic cervicitis, cervical intra-epithelial neoplasia grade 1 (CIN 1) and HPV infection were divided into two groups: patients treated with placebo and patients treated with DLE. Clinical and colposcopy evaluations were performed before and after treatments. Read More

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April 2018
2 Reads

Cervical Cancer Induction Enhancement Potential of Chlamydia Trachomatis: A Systematic Review.

Curr Microbiol 2018 Dec 22;75(12):1667-1674. Epub 2018 Jan 22.

Laboratory of Microbiology and Molecular Biology, Faculty of Medicine and Pharmacy of Fez (FMPF), Sidi Mohammed Ben Abdellah University (USMBA), Fez, Morocco.

Human papillomavirus (HPV) persistent infection is the necessary but not sufficient cause of cervical cancer. Other co-factors are required to induce cell transformation that will evolve to malignant cervical cancer. These co-factors include physical elements, other sexually transmitted infections, and immune response. Read More

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December 2018
5 Reads

Presence of histopathological premalignant lesions and infection caused by high-risk genotypes of human papillomavirus in patients with suspicious cytological and colposcopy results: A prospective study.

Vojnosanit Pregl 2017 Jan;74(1):24-30

Background/aim: In patients with premalignant cervical lesions, human papillomavirus (HPV) infection, at any moment, may be spontaneously eliminated, or may persist or transform cervical epithelium from a lower to a higher degree. Due to that, it is necessary to wisely select the patients who are at high risk of cancer development. The aim of the study was to establish the interdependence between a suspicious Papanicolaou (Pap) test and colposcopy with the infection caused by high-risk genotypes of human papillomavirus and the presence of premalignant cervical lesions. Read More

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January 2017
10 Reads

Human papillomavirus (HPV) 18 genetic variants and cervical cancer risk in Taizhou area, China.

Gene 2018 Mar 10;647:192-197. Epub 2018 Jan 10.

Laboratory of Gynecologic Oncology, Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, Zhejiang, China. Electronic address:

Human papillomavirus (HPV) type 18 is predominantly associated with the development of cervical adenocarcinomas, whereas data on HPV18 genetic variability in China are limited. HPV18 genetic variants were formed phylogenetic tree, including lineages A, B, and C. We aimed to evaluate the diversity of HPV18 genetic variants by sequencing the entire E6, E7 and L1 genes. Read More

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March 2018
7 Reads

Uterine Prolapse: Should Hysterectomy Specimens be Subjected for Histopathological Examination?

J Midlife Health 2017 Oct-Dec;8(4):179-182

Department of Obstetrics and Gynaecology, Christian Medical College, Ludhiana, Punjab, India.

Context: Uterine prolapse accounts for one of the common gynecological problems in India. The excised uterus is not expected to have any pathological finding other than atrophic endometrium and may be an ulcer because of the prolapse.

Aims: The aim of this study is to assess the hysterectomy specimen for unsuspected pathology. Read More

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January 2018
9 Reads

Human Papilloma Viruses and Their Genotype Distribution in Women with High Socioeconomic Status in Central Anatolia, Turkey: A Pilot Study.

Med Sci Monit 2018 Jan 4;24:58-66. Epub 2018 Jan 4.

Department of Obstetrics and Gynecology, Health Research System In Vitro Fertilization (HRS IVF) Center, Ankara, Turkey.

BACKGROUND In the present study we retrospectively evaluated the results of outpatients who had an HPV analysis, and present objective evidence for the administration of preventive inoculation in our area. MATERIAL AND METHODS We retrospectively reviewed 532 outpatients who visited a single center between 2012 and 2016 and had an HPV infection analysis. The criteria for inclusion of patients with unhealthy cervix in the study were: erosion, chronic cervicitis, healed lacerations, hypertrophied cervix, and abnormal discharges from the cervix. Read More

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January 2018
47 Reads

A proteomic profile of postpartum cervical repair in mice.

J Mol Endocrinol 2018 Jan;60(1):17-28

Department of BiologyAppalachian State University, Boone, North Carolina, USA

A timely and complete uterine cervical tissue repair postpartum is of necessity to prevent obstetrical complications, such as cervicitis, ectropion, hemorrhage, repeated miscarriages or abortions and possibly preterm labor and malignancies. We recently characterized the morphological alterations, as well as changes in angiogenic expression profile in a mice uterine cervix during the immediate postpartum period. Here, we build on this previous study using a proteomic analysis to profile postpartum tissue changes in mice cervix during the same period, the first 48 h of postpartum. Read More

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January 2018
4 Reads

Macrolide and fluoroquinolone resistance in Mycoplasma genitalium in two Swedish counties, 2011-2015.

APMIS 2018 Feb 13;126(2):123-127. Epub 2017 Dec 13.

Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, National Reference Laboratory for Sexually Transmitted Infections, Örebro University, Örebro, Sweden.

Mycoplasma genitalium, causing non-gonococcal non-chlamydial urethritis and associated with cervicitis, has developed antimicrobial resistance (AMR) to both the macrolide azithromycin (first-line treatment) and the fluoroquinolone moxifloxacin (second-line treatment). Our aim was to estimate the prevalence of resistance, based on genetic AMR determinants, to these antimicrobials in the M. genitalium population in two Swedish counties, Örebro and Halland, 2011-2015. Read More

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February 2018
10 Reads

Downregulation of nuclear and cytoplasmic Chibby is associated with advanced cervical cancer.

Oncol Lett 2017 Dec 25;14(6):6632-6644. Epub 2017 Sep 25.

Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan, R.O.C.

Chibby has been identified as a putative tumor suppressor and antagonist to β-catenin, thereby controlling the Wnt signaling pathway. Chibby is typically downregulated in numerous types of cancer and may be associated with tumorigenesis. The present study aimed at clarifying the following: i) Whether Chibby antagonizes β-catenin in cervical cancer; ii) whether Chibby and β-catenin mRNA expression is associated with cancer progression; and iii) whether Chibby and β-catenin expression may be used as a biomarker. Read More

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December 2017
3 Reads

Strain Types Have Diversified Regionally and Globally with Evidence for Recombination across Geographic Divides.

Front Microbiol 2017 13;8:2195. Epub 2017 Nov 13.

UCSF Benioff Children's Hospital Oakland Research Institute, Oakland, CA, United States.

() is the leading cause of bacterial sexually transmitted diseases worldwide. The Multi Locus Sequence Typing (MLST) scheme is effective in differentiating strain types (ST), deciphering transmission patterns and treatment failure, and identifying recombinant strains. Here, we analyzed 323 reference and clinical samples, including 58 samples from Russia, an area that has not previously been represented in typing schemes, to expand our knowledge of the global diversification of STs. Read More

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November 2017
7 Reads

Should we screen for the sexually-transmitted infection Mycoplasma genitalium? Evidence synthesis using a transmission-dynamic model.

Sci Rep 2017 Nov 23;7(1):16162. Epub 2017 Nov 23.

MRC Centre for Outbreak Analysis & Modelling, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, Norfolk Place, London, W2 1PG, UK.

There is increasing concern about Mycoplasma genitalium as a cause of urethritis, cervicitis, pelvic inflammatory disease (PID), infertility and ectopic pregnancy. Commercial nucleic acid amplification tests (NAATs) are becoming available, and their use in screening for M. genitalium has been advocated, but M. Read More

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November 2017
10 Reads

Public health approach to prevent cervical cancer in HIV-infected women in Kenya: Issues to consider in the design of prevention programs.

Gynecol Oncol Rep 2017 Nov 16;22:82-88. Epub 2017 Oct 16.

Department of Internal Medicine & Infectious diseases, University Hospital, Ghent, Belgium.

Women living with HIV in Africa are at increased risk to be co-infected with Human Papilloma Virus (HPV), persistent high risk (HR) HPV infection and bacterial vaginosis (BV), which compounds HPV persistence, thereby increasing the risk for cervical dysplasia. New guidance from WHO in 2014 advocating for a "screen and treat" approach in resource poor settings is becoming a more widely recommended screening tool for cervical cancer prevention programs in such contexts. This review article summarizes the risk factors to be considered when designing a primary and secondary cervical prevention program in a post-vaccination era for HIV-infected women in Kenya. Read More

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November 2017
6 Reads