Search Our Scientific Publications & Authors

Head Neck 2021 May 4. Epub 2021 May 4.

Department of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.

Background: We assessed the safety and efficacy of supracricoid partial laryngectomy with cricohyoidoepiglottopexy (SCL-CHEP) in patients with laryngeal cicatricial stenosis.

Methods: Sixteen patients receiving SCL-CHEP for severe laryngeal cicatricial stenosis between 2017 and 2018 were reviewed. Decannulation rate and tracheostomy closure time were used to evaluate efficacy. Read More

Bone Joint Res 2021 May;10(5):298-306

Shoulder Unit, Division of Orthopaedic Surgery, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Aims: Rotator cuff (RC) tears are common musculoskeletal injuries which often require surgical intervention. Noninvasive pulsed electromagnetic field (PEMF) devices have been approved for treatment of long-bone fracture nonunions and as an adjunct to lumbar and cervical spine fusion surgery. This study aimed to assess the effect of continuous PEMF on postoperative RC healing in a rat RC repair model. Read More

Orv Hetil 2021 05 2;162(18):690-695. Epub 2021 May 2.

3 Eastern Virginia Medical School, Department of Obstetrics and Gynecology, Division of Female Pelvic Medicine and Reconstructive Surgery, Norfolk, VA, United States of America.

Összefoglaló. Az ultrahang-elasztográfia az elmúlt évek során egyre növekvő figyelmet kapott a lágyszövetek elaszticitásának vizsgálatában. A módszer használatát az teszi szükségessé, hogy egyes, a mechanikai tulajdonságaikban különböző szövetek hasonló echogenitásúak lehetnek, valamint hogy egy adott szövet megváltozott struktúrája vagy mechanikai tulajdonsága nem minden esetben jár együtt a szövet hagyományos ultrahangképének megváltozásával. Read More

J Biomech 2021 Apr 17;122:110445. Epub 2021 Apr 17.

Department of Biomedical Engineering, Lund University, Sweden.

Low impact falls to the side are the main cause of hip fractures in elderly. Finite element (FE) models of the proximal femur may help in the assessment of patients at high risk for a hip fracture. However, extensive validation is essential before these models can be used in a clinical setting. Read More

Vaccines (Basel) 2021 Apr 19;9(4). Epub 2021 Apr 19.

Department of Oral Microbiology and Immunology and DRI, School of Dentistry, Seoul National University, Seoul 08826, Korea.

(pneumococcus) can cause respiratory and systemic diseases. Recently, γ-irradiation-inactivated, non-encapsulated, intranasal (r-SP) vaccine has been introduced as a novel serotype-independent and cost-effective vaccine. However, the immunogenic mechanism of r-SP is poorly understood. Read More

Plast Reconstr Surg Glob Open 2021 Mar 29;9(3):e3545. Epub 2021 Mar 29.

Division of Plastic and Reconstructive Surgery, Oakland University William Beaumont School of Medicine, William Beaumont Hospital, Royal Oak, Mich.

The coronavirus disease 2019 posed an unprecedented strain to plastic surgery services. The scarcity of validated guidelines-at the beginning of this healthcare crisis-to direct clinical, ethical, transparent decision-making for head and neck cancer patients requiring palliative reconstructive surgery was a difficult situation. We report a 15-year-old girl with an advanced chemoresistant rare radiotherapy-induced mandibular osteosarcoma during the early phase of the pandemic in the United States in mid-March 2020, when official recommendations for triage were still developing. Read More

Front Oncol 2021 7;11:626659. Epub 2021 Apr 7.

Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Epstein-Barr virus (EBV)-the prototypical human tumor virus-is responsible for 1-2% of the global cancer burden, but divergent strains seem to exist in different geographical regions with distinct predilections for causing lymphoid or epithelial malignancies. Here we report the establishment and characterization of Yu103, an Asia Pacific EBV strain with a highly remarkable provenance of being derived from nasopharyngeal carcinoma biopsy but subsequently propagated in human B-lymphoma cells and xenograft models. Unlike previously characterized EBV strains which are either predominantly B-lymphotropic or epitheliotropic, Yu103 evinces an uncanny capacity to infect and transform both B-lymphocytes and nasopharyngeal epithelial cells. Read More

Asian Nurs Res (Korean Soc Nurs Sci) 2021 Apr 21. Epub 2021 Apr 21.

Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China 250014.

Purpose: Nurses' musculoskeletal diseases (MSDs) are worldwide prevalent and are considered to be a costly occupational injury. This study aims to investigate the relationship among exposure to occupation-related psychosocial factors, physical workload, and upper body musculoskeletal diseases among hospital nurses.

Methods: An electronic search was implemented using nine databases with June 2019 as the latest search date. Read More

mSystems 2021 Apr 20;6(2). Epub 2021 Apr 20.

Department of Bioscience Engineering, University of Antwerp, Antwerp, Belgium

Chronic otitis media with effusion (OME) has been associated with a shift in microbiome composition and microbial interaction in the upper respiratory tract (URT). While most studies have focused on potential pathogens, this study aimed to find bacteria that could be protective against OME through a case-control microbiome study and characterization of isolates from healthy subjects. The URT and ear microbiome profiles of 70 chronic OME patients and 53 controls were compared by 16S rRNA amplicon sequencing. Read More

Brain Multiphys 2020 Nov 3;1. Epub 2020 Sep 3.

Center for Neuroscience and Regenerative Medicine, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.

The rapid deformation of brain tissue in response to head impact can lead to traumatic brain injury. In vivo measurements of brain deformation during non-injurious head impacts are necessary to understand the underlying mechanisms of traumatic brain injury and compare to computational models of brain biomechanics. Using tagged magnetic resonance imaging (MRI), we obtained measurements of three-dimensional strain tensors that resulted from a mild head impact after neck rotation or neck extension. Read More

West J Emerg Med 2020 Dec 16;22(2):410-416. Epub 2020 Dec 16.

University of Pennsylvania, Perelman School of Medicine, Department of Orthopaedic Surgery, Philadelphia, Pennsylvania.

Introduction: Wrestling is one of the fastest-growing sports among females in the United States (US). However, female wrestling injuries remain poorly characterized. In this study we describe historical and projected national estimates of female wrestling injuries, and compare injury characteristics with those of male wrestlers. Read More

Pediatr Emerg Care 2021 Apr 9. Epub 2021 Apr 9.

From the *Division of Pediatric Emergency Medicine, Rainbow Babies & Children's Hospital †Division of Pediatric Hospital Medicine, Rainbow Babies & Children's Hospital, University Hospitals Cleveland Medical Center ‡Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH.

Objectives: Injuries are the leading cause of morbidity and mortality in children ages 1 to 18 years. There are limited studies about pediatric thoracolumbar (TL) spinal injuries; the purpose of this study was to characterize TL spinal injuries among pediatric patients evaluated in US trauma centers.

Methods: This was a retrospective cohort study of the National Trauma Data Bank. Read More

J Speech Lang Hear Res 2021 04 5;64(4):1197-1209. Epub 2021 Apr 5.

Department of Biomedical Engineering, Boston University, MA.

Purpose Prior work suggests that voice onset time (VOT) may be impacted by laryngeal tension: VOT means decrease when individuals with typical voices increase their fundamental frequency () and VOT variability is increased in individuals with vocal hyperfunction, a voice disorder characterized by increased laryngeal tension. This study further explored the relationship between VOT and laryngeal tension during increased , vocal effort, and vocal strain. Method Sixteen typical speakers of American English were instructed to produce VOT utterances under four conditions: baseline, high pitch, effort, and strain. Read More

Clin Exp Dent Res 2021 Mar 31. Epub 2021 Mar 31.

Department of Oral Microbiology and Immunology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Objective: To determine acid-producing capacity and anti-microbial activity of Lactobacillus species collected pretreatment and post treatment in head and neck cancer patients.

Material And Methods: Lactobacillus isolates from 21 patients pretreatment and post treatment were identified using molecular methods. The patients' stimulated salivary secretion was determined pretreatment, and 6 and 12 months post treatment and caries lesions/new filled surfaces registered at 24 months post treatment. Read More

Z Rheumatol 2021 Mar 29. Epub 2021 Mar 29.

Department of Medical Ecology and Hydroclimatology, Istanbul Faculty of Medicine, Istanbul University, Topkapı, Turgut Özal Millet Cd, 34093, Fatih/İstanbul, Turkey.

Objective: The goal was to assess public interest in a wide range of musculoskeletal symptoms and disorders during the coronavirus disease 2019 (COVID-19) pandemic.

Methods: We searched Google Trends for 118 search queries within the United States. We compared two timeframes of 2020 (March 15-July 4 and July 5-October 31) to similar timeframes over the four prior years (2016-2019). Read More

Int Orthop 2021 Mar 28. Epub 2021 Mar 28.

Department of Orthopaedics, First Faculty of Medicine, Charles University and Central Military Hospital Prague, Prague, Czech Republic.

Miller Edwin Preston (1879-1928) is cited in the literature in connection with the first angled implant for the fixation of fractures of the femoral neck. Further research has shown that this surgeon emphasised the principles of internal fixation and is the author of several extraordinary and still-valid concepts: "There is no branch of surgery in which nature is more exacting than bone work. To be successful in this field, the cases must be carefully selected, the most rigid asepsis should be observed, the surgeon must possess a good working knowledge of anatomy and fully appreciate the laws of stress, strain and leverage. Read More

J Craniofac Surg 2021 Mar 22. Epub 2021 Mar 22.

Graduate Program in Biomedical Engineering, The University of Western Ontario Schulich School of Medicine and Dentistry, The University of Western Ontario Otolaryngology-Head and Neck Surgery, The University of Western Ontario Mechanical and Materials Engineering, The University of Western Ontario, London, Ontario, Canada.

Abstract: Zygomaticomaxillary complex fractures are common in midface trauma, with treatment often involving repair using titanium mini plates. However, the need for plate fixation along the zygomaticomaxillary suture on the infraorbital rim remains controversial. This study utilized a previously reported bite force simulator to investigate craniofacial strain patterns following zygomaticomaxillary complex fracture repairs with and without plating of the infraorbital rim. Read More

J Craniofac Surg 2021 Mar 24. Epub 2021 Mar 24.

Department of Ophthalmology, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur, Malaysia.

Background: To evaluate the satisfaction of surgeons and trainees with three-dimensional (3D) ophthalmic surgery during a demonstration compared to traditional surgery.

Methods: This validated questionnaire-based study was conducted over 1-month during which Ngenuity 3D surgery was demonstrated. All surgeons and trainees exposed were recruited to complete a questionnaire comprising visualization, physical, ease of use, teaching and learning, and overall satisfaction. Read More

Clin Biomech (Bristol, Avon) 2021 Mar 20;84:105329. Epub 2021 Mar 20.

Department of Orthopedic Surgery, Division of Spine Surgery, Schön-Kliniken Düsseldorf, Düsseldorf, Germany.

Introduction: Biomechanical functionality as well as trauma mechanisms of the atlantoaxial complex are still an issue of controversy. The transverse atlantal ligament is the strongest stabilizator. The present study aimed to analyze the bending forces of the transverse atlantal ligament and of the base of the odontoid in elderly specimens. Read More

Regen Biomater 2021 Mar 13;8(2):rbaa061. Epub 2021 Mar 13.

Ningbo Regen Biotech Co., Ltd, 199 East Hexiao Road, Ningbo, 315157, People's Republic of China.

There has been an increase in the incidence of hypopharyngeal and cervical esophageal cancer worldwide, and hence growing needs for hypopharyngeal and cervical esophageal tissue repair. This work produced a bi-layer composite scaffold with decellularized small intestine submucosa and polylactic-co-glycolic acid, which resembled the layered architectures of its intended tissues. The decellularized small intestine submucosa contained minimal residual DNA (52. Read More

J Otolaryngol Head Neck Surg 2021 Mar 17;50(1):17. Epub 2021 Mar 17.

Division of Otolaryngology Head & Neck Surgery, Department of Surgery, University of British Columbia, 4th Floor, 2775 Laurel Street, Vancouver, BC, V5Z1M9, Canada.

Background: Gastric pull-up is a reconstructive option for circumferential defects after resection of advanced laryngopharyngeal malignancy. Voice loss is expected and vocal rehabilitation remains a challenge. Our study objectives were to investigate the feasibility of secondary tracheoesophageal puncture following gastric pull-up and to analyze voice outcomes. Read More

G3 (Bethesda) 2021 Mar 15. Epub 2021 Mar 15.

Division of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States of America.

Specific fat distributions are risk factors for complex diseases, including coronary heart disease and obstructive sleep apnea. To demonstrate the utility of high-diversity mouse models for elucidating genetic associations, we describe the phenotyping and heritability of fat distributions within the five classical inbred and three wild-derived founder mouse strains of the Collaborative Cross and Diversity Outbred mice. Measurements of subcutaneous and internal fat volumes in the abdomen, thorax and neck, and fat volumes in the tongue and pericardium were obtained using magnetic resonance imaging in male mice from the A/J (n = 12), C57BL/6J (n = 17), 129S1/SvlmJ (n = 12), NOD/LtJ (n = 14), NZO/HILtJ (n = 12), CAST/EiJ (n = 14), PWK/PhJ (n = 12), and WSB/EiJ (n = 15) strains. Read More

J Clin Orthop Trauma 2021 Apr 15;15:99-103. Epub 2020 Oct 15.

Ganga Medical Center and Hospitals Pvt-ltd., Coimbatore, India.

Background: Quantitative bone re-modelling theories suggest that bones adapt to mechanical loading conditions. Follow-up studies have shown that total disc replacement (TDR) modifies stress patterns in the bones, leading to heterotopic ossification (HO). Although there are a few studies on HO using finite element models (FEM), its effect on the adjacent levels and change in range of motion (ROM) have not been adequately investigated. Read More

J Forensic Leg Med 2021 Apr 26;79:102150. Epub 2021 Feb 26.

Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

Background: Injury and deaths inflicted by law enforcement are a topic of significant discussion in the US. The purpose of this study was to analyze injuries due to law enforcement activity that presented to emergency departments (ED) across the entire US and correlate the injury patterns with patient demographics.

Methods: The National Electronic Injury Surveillance System (NEISS) All Injury Program (AIP) data was used for the years 2005 through 2015. Read More

Sci Adv 2021 Mar 12;7(11). Epub 2021 Mar 12.

Department of Mechanical Engineering, City University of Hong Kong, Hong Kong, China.

The prevention of work-related upper extremity musculoskeletal disorders (MSDs; e.g., neck pain and shoulder fatigue) requires frequent exercises of neck and shoulder that primarily rely on the assistance of joint motion monitoring devices. Read More

BMC Oral Health 2021 03 10;21(1):109. Epub 2021 Mar 10.

Department of Orthodontics, School of Stomatology, Capital Medical University, No. 4, Tian Tan Xi Li, Beijing, 100050, China.

Background: Pathologic tooth migration (PTM) is a common complication of mild to severe periodontitis and proper orthodontic treatment is helpful to alleviate periodontal diseases. The goal of this study is to explore an optimal orthodontic displacement of clear aligner using a three-dimensional (3D) finite element model (FEM).

Methods: The cone beam computed tomography (CBCT) data of a patient received invisible orthodontics without diabetes and other systemic diseases were collected. Read More

J Appl Biomech 2021 Mar 8:1-8. Epub 2021 Mar 8.

University of Ottawa.

Understanding the relationship between head mass and neck stiffness during direct head impacts is especially concerning in youth sports where athletes have higher proportional head mass to neck strength. This study compared 2 neck stiffness conditions for peak linear and rotational acceleration and brain tissue deformations across 3 impact velocities, 3 impact locations, and 2 striking masses. A pendulum fitted with a nylon cap was used to impact a fifth percentile hybrid III headform equipped with 9 accelerometers and fitted with a youth American football helmet. Read More

Front Vet Sci 2021 17;8:595511. Epub 2021 Feb 17.

Aklilu Lemma Institute of Pathobiology, Sefere Selam Campus, Addis Ababa University, Addis Ababa, Ethiopia.

Bovine tuberculosis (bTB) continues to be one of the most widely distributed chronic infectious diseases of zoonotic importance, which causes a significant economic loss in animal production. A cross-sectional study was conducted to estimate the prevalence of bTB and its associated risk factors and type the isolated in central Ethiopia. A total of 65 dairy farms and 654 cattle were tested for bTB using a single intradermal comparative cervical tuberculin (SICCT) test. Read More

Sleep Breath 2021 Mar 7. Epub 2021 Mar 7.

Sleep Medicine Center, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, 100029, China.

Background: Early detection of left ventricular (LV) dysfunction is crucial in obstructive sleep apnea (OSA) due to its close relationship with cardiovascular diseases. Global longitudinal strain (GLS) derived from automated function imaging (AFI) can precisely assess global longitudinal function. The aim of this study was to determine if LV GLS was reduced in patients with OSA and a normal LV ejection fraction (LVEF) and to assess any associated determinants. Read More

Hear Res 2021 May 21;404:108215. Epub 2021 Feb 21.

Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Efferent innervation of the inner hair cells changes over time. At an early age in mice, inner hair cells receive efferent feedback, which helps fine-tune tonotopic maps in the brainstem. In adulthood, inner hair cell efferent innervation wanes but increases again in older animals. Read More