Clin Neurol Neurosurg 2022 May 28;219:107309. Epub 2022 May 28.
Department of Neurosurgery, Hotel-Dieu de France Hospital & Saint Joseph University, Beirut, Lebanon; Laboratory of Research in Neuroscience, Faculty of Medicine, Pôle Technologie Santé, Saint Joseph University, Beirut, Lebanon. Electronic address:
Background And Objectives: Optimal medical treatment for low back pain, sometimes associated to radicular pain, has yet to be established. Herniated nucleus pulposus has been found to release TNFα, a pro-inflammatory cytokine involved in radiculopathy. Interestingly, Pentoxifylline (PTX), a phosphodiesterase inhibitor, blocks the activity of TNFα. Read More