523,805 results match your criteria Cervical Radiculopathy


Targeting cervical cancer campaigns on teenage high schoolers in resource-limited economies: lessons from an intervention study of Nigerian senior secondary school girls.

Fam Pract 2018 Dec 12. Epub 2018 Dec 12.

Department of Community Medicine and Primary Healthcare, Chukwuemeka Odumegwu Ojukwu University/University Teaching Hospital, Awka, Nigeria.

Background: Given the dearth of government-sponsored programmes, preventive lifestyles and practices are the realistic hopes for millions of women in developing countries against cervical cancer. Early interventions for teenage high school girls have been advocated recently, but evidence-base for sustainable activities at this demographic is lacking. This article reduces this gap by determining the impact of two cervical cancer education techniques. Read More

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December 2018

Microneurosurgical Removal of a Cervical Intramedullary Tumor Via Hemilaminoplasty: 3-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurosurgery, Yeditepe University School of Medicine, Istanbul, Turkey.

Intramedullary tumors of the spinal cord are rare and account for 2% to 8.5% of all central nervous system tumors. In adults, ependymomas are the most common intramedullary tumors. Read More

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December 2018

Measurements of Trunk Sway for Stance and Gait Tasks 2 Years after Vestibular Neurectomy.

Audiol Neurootol 2018 Dec 12;23(5):298-308. Epub 2018 Dec 12.

Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

The aim of this study was to investigate changes in balance control for stance and gait tasks in patients 2 years before and after vestibular neurectomy (VN) performed to alleviate intractable Meniere's disease. Amplitudes of trunk sway in roll and pitch directions were measured for stance and gait tasks in 19 patients using gyroscopes mounted at the lower-back. Measurements before VN and 2 years later were compared to those of healthy age-matched controls (HC). Read More

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December 2018

Aggressive fibromatosis of the parotid gland.

Ear Nose Throat J 2018 Dec;97(12):E28-E30

Department of Otolaryngology-Head and Neck Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.

Extra-abdominal fibromatosis (EAF) is a rare, locally aggressive tumor that originates in fascial structures. It accounts for less than 0.3% of all tumors diagnosed. Read More

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December 2018

Destructive lesion of the temporomandibular joint: A case of tophaceous pseudogout.

Ear Nose Throat J 2018 Dec;97(12):E18-E20

Department of Otolaryngology-Head and Neck Surgery, Virginia Commonwealth University, West Hospital, 1200 East Broad St., 12th Floor, South Wing, Suite 313, Box 980146, Richmond, VA 23298-0146, USA.

Tophaceous pseudogout of the temporomandibular joint is a rare entity that clinically and radiographically mimics neoplastic or infectious conditions. Diagnosis requires histopathologic examination. Given the rarity of this condition, there is a paucity of information pertaining to the surgical approach, reconstructive options, and postoperative outcomes. Read More

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December 2018

A fistulating oropharyngeal lesion.

Ear Nose Throat J 2018 Dec;97(12):E15-E17

Department of Otorhinolaryngology-Head and Neck Surgery, Mayo Clinic Arizona, 5777 E. Mayo Blvd., Phoenix, AZ 85084, USA.

Post-transplant lymphoproliferative disorder (PTLD) is a unifying term for a spectrum of lymphoid expansion entities brought about by immunosuppression. It can present throughout the head and neck, and tonsillar involvement is not limited to children. We report the case of a 67-year-old woman who developed odynophagia associated with putrid halitosis 4 months after she had undergone renal transplantation. Read More

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December 2018

Red ear syndrome: Perspectives for the otolaryngologist.

Ear Nose Throat J 2018 Dec;97(12):E11-E14

Department of Otolaryngology, Lenox Hill Hospital/Northwell Health, 110-11 72nd Ave., Suite 1B, Forest Hills, NY 11375, USA.

Red ear syndrome (RES) is an unusual, often unrecognized condition that has rarely been reported in the otolaryngology literature despite the presence of symptoms and associated disorders of relevance to the otolaryngologist. When present, RES may have diagnostic value when uncertainties arise in cases of sinus headache and referred otalgia. Despite the appearance of a distinctive red ear, as well as symptoms and associated disorders relating to otolaryngology, discussion of RES is generally limited to neurology-based publications. Read More

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December 2018

An unusual presentation of papillary thyroid carcinoma in a pediatric patient: A case report.

Ear Nose Throat J 2018 Dec;97(12):E7-E10

University of Arizona College of Medicine - Tucson, 1501 N. Campbell Ave., PO Box 245017, Tucson, AZ 85724, USA.

Cystic neck masses in the pediatric population are common but rarely concerning for malignancy. Given this typically benign nature, they are frequently managed conservatively. Here we present an unusual case of a waxing and waning cystic neck mass in a pediatric patient. Read More

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December 2018

Endoscopic medialization middle turbinoplasty in endoscopic sinus surgery.

Ear Nose Throat J 2018 Dec;97(12):404-410

Department of Otolaryngology-Head and Neck Surgery, Tufts University School of Medicine, Tufts Medical Center, 800 Washington St., Box 850, Boston, MA 02111, USA. Email:

Recurrence of sinonasal disease can be caused by many factors, including lateralization of the middle turbinate as a complication of endoscopic sinus surgery (ESS). Different ESS procedures have been tried to prevent this complication. We conducted a prospective study to determine if medialization is an effective means of lateralizing the middle turbinate. Read More

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December 2018

KTP-laser-assisted endoscopic management of glomus tympanicum tumors: A case series.

Ear Nose Throat J 2018 Dec;97(12):399-402

Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Rd., Stanford, CA 94035, USA.

Endoscopic technology is widely used in rhinology and anterior skull base surgery, but it has been less quickly incorporated into otologic practice. The design of the instrumentation forces surgeons to work one-handed and limits depth perception. Nevertheless, endoscopy also offers wide fields of view and access to spaces that are typically difficult to visualize. Read More

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December 2018

Association of Ménière disease with human leukocyte antigen in Taiwanese population.

Ear Nose Throat J 2018 Dec;97(12):396-402

College of Medicine, Chang Gung University, Taoyuan, Taiwan.

The etiology of Ménière disease (MD) is multifactorial; genetic factors seem to play an important role. The associations between MD and human leukocyte antigen (HLA) status have been studied previously in several populations and have shown that the HLA alleles imparting susceptibility varied. In the present study, we explored HLA status in Taiwanese patients with definitive MD. Read More

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December 2018

Unforeseen consequence of alkaline water therapy for laryngopharyngeal reflux.

Ear Nose Throat J 2018 Dec;97(12):394-395

Department of Otolaryngology-Head and Neck Surgery, Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA.

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December 2018

In-office sinonasal procedures in the elderly.

Ear Nose Throat J 2018 Dec;97(12):392-393

Department of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, Canada.

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December 2018

An unusual case of persistent dysphagia.

Ear Nose Throat J 2018 Dec;97(12):391

Department of Otolaryngology-Head and Neck Surgery, West Virginia University School of Medicine, Morgantown, WV, USA.

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December 2018

Huge neck lymphangioma removed in toto with minimal access.

Ear Nose Throat J 2018 Dec;97(12):389-390

Department of ENT and Head and Neck Surgery, Maulana Azad Medical College, New Delhi, India.

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December 2018

[Influence of HPV infection on cell cycle regulation in epithelial cell alterations of cervix uteri: Immunohistochemical and in situ hybridization observations].

Magy Onkol 2018 Dec 25;62(4):264-271. Epub 2018 Nov 25.

Daganatpatológiai Központ, Országos Onkológiai Intézet, Budapest, Hungary.

The HPV16 E6 DNA incorporation into the cervical epithelial cell genome was determined. In addition, using p16, p21 and p27 protein immunohistochemistry, we intended to present how the normal cell cycle machinery was disturbed in cervical epithelial cells. In CIN1 the epithelial cells are transformed into koilocytes, p16 is not expressed. Read More

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December 2018

[Clinical results of combined intracavitary-interstitial image-guided adaptive brachytherapy in locally advanced cervical cancer].

Magy Onkol 2018 Dec 10;62(4):249-257. Epub 2018 Aug 10.

Onkológiai Tanszék, Semmelweis Egyetem, Általános Orvostudományi Kar, Budapest, Hungary.

We present the early clinical results achieved with image-guided adaptive brachytherapy (IGABT) with combined intracavitary-interstitial (IC-IS) technique recently implemented in Hungary in the treatment of locally advanced cervical cancer (LACC). Twenty-one patients were treated with radio-chemotherapy (RCT) followed by combined IC-IS BT. At the end of the RCT we assessed the residual tumour with pelvic MRI. Read More

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December 2018

[Dosimetric evaluation of intracavitary-interstitial image-guided adaptive brachytherapy of cervical cancer and comparison with conventional treatment techniques].

Magy Onkol 2018 Dec 31;62(4):242-248. Epub 2018 Aug 31.

Onkológiai Tanszék, Semmelweis Egyetem, Általános Orvostudományi Kar, Budapest, Hungary.

Our aim was the dosimetric evaluation of intracavitary-interstitial high-dose-rate image-guided adaptive cervix brachytherapy, implemented in Hungary. Between 2016 and 2018, 21 patients with cervical cancer were treated with overall 72 fractions. Graphical optimized treatment plans were compared to inverse optimized plans, 3D optimized plans (without needles) and conventional intracavitary 2D plans. Read More

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December 2018

Decomposing the subclonal structure of tumors with two-way mixture models on copy number aberrations.

PLoS One 2018 12;13(12):e0206579. Epub 2018 Dec 12.

Institute of Statistics, National Tsing Hua University, Hsinchu, Taiwan, R.O.C.

Multistage tumorigenesis is a dynamic process characterized by the accumulation of mutations. Thus, a tumor mass is composed of genetically divergent cell subclones. With the advancement of next-generation sequencing (NGS), mathematical models have been recently developed to decompose tumor subclonal architecture from a collective genome sequencing data. Read More

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December 2018

Predictive Value of Head-Neck CTA Combined with ABCD2 Scale Score for Patients with Cerebral Infarction of Vertebrobasilar Transient Ischemic Attack (TIA).

Med Sci Monit 2018 Dec 12;24:9001-9006. Epub 2018 Dec 12.

Department of Radiology, Baoding First Central Hospital, Beijing, China (mainland).

BACKGROUND The present study was designed to evaluate the predictive value of head-neck computed tomography angiography (CTA) combined with ABCD2 score scale for patients with cerebral infarction of vertebrobasilar transient ischemic attack (TIA). MATERIAL AND METHODS A total of 92 patients with TIA who were admitted to our hospital from January 2014 to June 2015 were enrolled in this study. ABCD2 score and CTA combined with ABCD2 score were assessed. Read More

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December 2018

Poor Baseline Mental Health Does Not Influence Improvement in Patient-Reported Outcomes, Satisfaction and Return To Work Two Years After Single-Level Anterior Cervical Discectomy and Fusion.

Spine (Phila Pa 1976) 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopedic Surgery, Singapore General Hospital, Singapore.

Study Design: Retrospective study using prospectively collected registry data.

Objectives: The authors examine the influence of preoperative mental health on outcomes after anterior cervical discectomy and fusion (ACDF) and determine the impact of ACDF on postoperative mental health.

Summary Of Background Data: While studies have reported a negative correlation between preoperative mental health and outcomes following lumbar spine surgery, the influence on outcomes following cervical spine surgery remains relatively understudied. Read More

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December 2018

Limited Sequence MRI's for Early Onset Scoliosis Patients Detected 100% of Neural Axis Abnormalities While Reducing MRI Time by 68.

Spine (Phila Pa 1976) 2018 Dec 11. Epub 2018 Dec 11.

Children's Orthopaedic Center, Children's Hospital Los Angeles.

Study Design: Diagnostic accuracy.

Objective: The purpose of this study was to determine if neural axis abnormalities in early onset scoliosis (EOS) patients can be reliably detected with limited magnetic resonance imaging (MRI) sequences (sagittal T1, sagittal T2).

Summary Of Background Data: MRI's are often performed in EOS patients as studies have shown there are neural axis abnormalities in up to 40% of this population. Read More

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December 2018

Long-term Outcomes of Ossiculoplasty With and Without an Intact Malleus.

Otol Neurotol 2019 Jan;40(1):73-78

Division of Otology and Neurotology, Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Objective: To compare long-term hearing outcomes following ossiculoplasty with cartilage tympanoplasty with (M) and without (M) the malleus present.

Study Design: Retrospective chart review.

Setting: Tertiary referral center. Read More

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January 2019

Novel Treatment Options for the Surgical Management of Young Femoral Neck Fractures.

J Orthop Trauma 2019 Jan;33 Suppl 1:S33-S37

Orthopaedic Trauma Service, Hospital for Special Surgery, New York, NY.

In physiologically young patients with displaced femoral neck fractures, surgical treatment is aimed at achieving fracture union while preserving native hip anatomy and biomechanics. The intracapsular environment, tenuous vascular supply, and unfavorable hip biomechanics contribute to the high complication rates seen after osteosynthesis of these fractures. Conventional fixation methods for osteosynthesis of femoral neck fractures include multiple cancellous screws, fixed-angle dynamic implants, and fixed-angle length-stable constructs. Read More

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January 2019

Biomechanics of Femoral Neck Fractures and Implications for Fixation.

J Orthop Trauma 2019 Jan;33 Suppl 1:S27-S32

*Institute for Biomechanics, BG Unfallklinik Murnau, Murnau, Germany; and †Institute for Biomechanics, Paracelsus Medical University Salzburg, Salzburg, Austria.

Fractures of the femoral neck can occur in young healthy individuals due to high loads occurring during motor vehicle accidents, impacts, or falls. Failure forces are lower if impacts occur sideways onto the greater trochanter as compared with vertical loading of the hip. Bone density, bone geometry, and thickness of cortical bone at the femoral neck contribute to its mechanical strength. Read More

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January 2019

Technologies for Young Femoral Neck Fracture Fixation.

J Orthop Trauma 2019 Jan;33 Suppl 1:S20-S26

Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston-Salem, NC.

Fixation of young femoral neck fractures represents a challenge in the field of orthopaedic trauma surgery. Conventional methods, including cannulated screw and sliding hip screw constructs, have been studied and found to have similar results with regards to patient outcomes, which has made choosing an optimum fixation strategy difficult. In all of these cases, quality of reduction has been shown to be the most important factor when it comes to creating a favorable environment for fracture healing. Read More

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January 2019

Reduction Techniques for Young Femoral Neck Fractures.

Authors:
Jason Halvorson

J Orthop Trauma 2019 Jan;33 Suppl 1:S12-S19

Department of Orthopedic Surgery, Wake Forest Baptist Medical Center, Winston-Salem, NC.

Young femoral neck fractures remain challenging fractures to treat. Reduction has repeatedly been shown to be the single most important determinant of patient outcome, and treating surgeons should do all they can to achieve anatomic reduction because this is an outcome variable within the surgeon's control. Whether an open or closed reduction is performed, we hope to provide the reader with reduction strategies when faced with this difficult fracture pattern. Read More

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January 2019

Femoral Neck Fractures in Young Patients: State of the Art.

Authors:
Daniel S Chan

J Orthop Trauma 2019 Jan;33 Suppl 1:S7-S11

Orthopaedic Trauma Institute, NavicentHealth, Macon, GA.

Femoral neck fractures in young patients are uncommon but are often associated with surgical challenges and complications. The quality of reduction, more than time to surgery, has the most impact on optimizing outcomes and function. There is no consensus in the best fixation construct for these fractures. Read More

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January 2019

Treatment of Young Femoral Neck Fractures.

J Orthop Trauma 2019 Jan;33 Suppl 1:S1-S6

Department Orthopaedic Surgery, Wake Forest University School of Medicine, Winston-Salem, NC.

Femoral neck fractures in the physiologically young patient are challenging injuries to manage. A tenuous blood supply and the intrasynovial nature of the fracture create a challenging biological environment. To make matters worse, the biomechanics are equally problematic. Read More

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January 2019

Femoral Neck Fractures in the Physiologically Young Patient.

Authors:
Eben A Carroll

J Orthop Trauma 2019 Jan;33 Suppl 1:S1

Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston-Salem, NC.

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January 2019

Surgical Algorithmic Approach to Facilitate Primary Closure of the Anterolateral Thigh Flap Donor Site in Head and Neck Reconstruction.

Ann Plast Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of Plastic and Reconstructive Surgery, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City, Taiwan.

Background: Use of the anterolateral thigh (ALT) flap has gained popularity in head and neck reconstruction. However, donor sites that cannot achieve primary closure are reported to have poorer functional and aesthetic outcomes. Therefore, we propose an algorithm to facilitate primary closure of the donor site. Read More

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December 2018
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mTOR, glycotoxins and the parallel universe.

Authors:
Alan S Green

Aging (Albany NY) 2018 Dec 12. Epub 2018 Dec 12.

The Medical Practice of Dr. Alan S. Green, Little Neck, NY 11363, USA.

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December 2018

[Aim: In France, cervical cancer screening has led to a decrease in mortality, though it could be optimized by improving the management of abnormal cytology. The aim was to evaluate the follow-up of women with abnormal Pap smear prescribed by an ambulatory health professional, compared to the ANAES guidelines of 2002.Method: Quantitative monocentric and retrospective study of 120 women with abnormal Pap smear performed before October 2014 in the French department of the Loire.Results: 114 abnormal Pap smear follow-ups of women between the ages of 18 and 75 have been analyzed. Cytological abnormalities were spread among 90 ASC-US (79%), 16 LSIL (14%), 6 HSIL (5,3%) and 2 ASC-H (1,7%). Compared to the ANAES guidelines, 52% of follow-ups were incomplete, 24% were comprehensive with too long of a delay, and 24% were guidelines compliant. Women under 29 were more likely to have an incomplete follow-up: OR 0,306 [0,116-0,805].Conclusion].

Sante Publique 2018 Oct;30(4):527-532

Aim: In France, cervical cancer screening has led to a decrease in mortality, though it could be optimized by improving the management of abnormal cytology. The aim was to evaluate the follow-up of women with abnormal Pap smear prescribed by an ambulatory health professional, compared to the ANAES guidelines of 2002.

Method: Quantitative monocentric and retrospective study of 120 women with abnormal Pap smear performed before October 2014 in the French department of the Loire. Read More

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October 2018

[Introduction: During the study, the HAS (French Board of Health) recommended 3 options for the first test (C1) in case of presence of ASC-US: a smear to be carried out after 6 months, an HPV test or a colposcopy.Our main objective was to find out which C1 option was chosen. The secondary objectives were to evaluate the number of C1’s carried out by general practitioners, the follow-up rate and that of adapted C1 smear reports.Method: Retrospective descriptive study based on the data obtained from CAP Santé 49 (departmental organization of cancer screening), concerning women between the ages of 25 and 65 years old having had a smear test with a positive ASC-US result carried out by a general practitioner.Results: Based on 397 female patients, 373 with a 94% follow-up of which 367 C1’s and 6 treatments. Among the C1’s: 212 smears (57.76%), 89 tests HPV (24.25%), 40 colposcopies (10.9%), 26 double techniques (7.08%). 235 representing 64.03% were carried out by general practitioners, 130 representing 35.42% by gynecologists and 2 representing 0,54% by midwives. Of the 126 normal smear reports received by general practitioners, 70.63% gave information about an ASC-US antecedent. Among them 14 representing 15.7% complied with the recommended specified time intervals.Conclusion].

Sante Publique 2018 Oct;30(4):499-505

Introduction: During the study, the HAS (French Board of Health) recommended 3 options for the first test (C1) in case of presence of ASC-US: a smear to be carried out after 6 months, an HPV test or a colposcopy.Our main objective was to find out which C1 option was chosen. The secondary objectives were to evaluate the number of C1's carried out by general practitioners, the follow-up rate and that of adapted C1 smear reports. Read More

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October 2018

Oxidative stress: therapeutic approaches for cervical cancer treatment.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e548s. Epub 2018 Dec 10.

Instituto do Cancer do Estado de Sao Paulo ICESP, Centro de Investigacao Translacional em Oncologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Objectives: Oxidative stress results from an imbalance between the generation and elimination of oxidant species. This condition may result in DNA, RNA and protein damage, leading to the accumulation of genetic alterations that can favor malignant transformation. Persistent infection with high-risk human papillomavirus types is associated with inflammatory responses and reactive oxygen species production. Read More

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December 2018

Effect of fluoride application during radiotherapy on enamel demineralization.

J Appl Oral Sci 2018 Dec 10;27:e20180044. Epub 2018 Dec 10.

Universidade Federal de Uberlândia, Faculdade de Odontologia, Departamento de Dentística e Materiais Odontológicos, Uberlândia, Minas Gerais, Brasil.

Objective: Radiation-related caries are one the most undesired reactions manifested during or after head and neck radiotherapy. Fluoride application is an important strategy to reduce demineralization and enhance remineralizaton. To evaluate the effect of the topical application of fluoride during irradiation on dental enamel demineralization. Read More

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December 2018

PATHOLOGIC COMPLETE RESPONSE (YPT0 YPN0) AFTER CHEMOTHERAPY AND RADIOTHERAPY NEOADJUVANT FOLLOWED BY ESOPHAGECTOMY IN THE SQUAMOUS CELL CARCINOMA OF THE ESOPHAGUS.

Arq Bras Cir Dig 2018 Dec 6;31(4):e1405. Epub 2018 Dec 6.

Digestive Diseases Surgical Unit and Gastrocenter, Department of Surgery, School of Medical Sciences, State University of Campinas - UNICAMP , Campinas, SP, Brazil.

Background: Esophageal squamous cell carcinoma is an aggressive neoplasia that requires a multidisciplinary treatment in which survival and prognosis are still not satisfactory. The complete pathologic response to neoadjuvant chemotherapy and radiotherapy is considered a good prognosis factor, and esophagectomy is indicated.

Aim: Survival analysis of cases with pathologic complete response (ypT0 ypN0) to neoadjuvant chemotherapy and/or radiotherapy, submmitted to esophagectomy. Read More

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December 2018

Oral health-related quality of life among male subjects with oral submucous fibrosis in a tertiary care hospital.

Indian J Public Health 2018 Oct-Dec;62(4):271-276

Senior Resident, Oral Health Sciences Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, Union Territory, India.

Background: Oral submucous fibrosis is very common in Asia. It has many deleterious effects on individual's oral functions. Thus, there is a need to assess the effect of oral submucous fibrosis on quality of life. Read More

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December 2018

Multiple intercostal neurilemmomas in a Chinese woman.

J Cancer Res Ther 2018 Dec;14(Supplement):S1220-S1222

Department of Respiratory and Critical Care Medicine, Jinling Hospital, Nanjing University Medical School, Nanjing, People's Republic of China.

Neurilemmomas are rare tumors of neural crest cell origin that occur most commonly in the head and neck region. Intercostal neurilemmomas are extremely rare and are mostly seen as solitary tumors in the posterior mediastinum. Only one case report of multiple intercostal neurilemmomas has been documented previously. Read More

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December 2018

Concurrent computed tomography-guided radioactive iodine-125 seeds percutaneous interstitial implantation and chemotherapy for treatment of cervical lymph node metastases.

J Cancer Res Ther 2018 Dec;14(Supplement):S1163-S1169

Department of Neurology, People's Hospital of LinZi District, Affiliated to Binzhou Medical College, Zibo, China.

Aim: The study aimed to evaluate the effect of concurrent computed tomography (CT)-guided percutaneous interstitial implantation of iodine-125 (I) seeds and chemotherapy on cervical lymph nodes metastasis.

Methods: The prospective randomized study included 82 cases with cervical lymph nodes metastasis who were admitted to our hospital from January 2010 to June 2012. All the subjects were randomly divided into the concurrent I implantation and chemotherapy group (n = 48) and chemotherapy-only group (n = 34) according to the treatment strategy. Read More

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December 2018

Meta-analysis of the relationship between excision repair cross-complementing Group 5 rs17655 gene polymorphism and head and neck cancer susceptibility.

J Cancer Res Ther 2018 Dec;14(Supplement):S1041-S1047

Department of Traditional Chinese Medicine, Scientific Research Platform, The Second Clinical Medical College, Guangdong Medical University; Department of Dongguan Scientific Research Center, Sino-American Cancer Research Institute, Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan, Guangdong, China.

Background: Published studies have evaluated the association between excision repair cross-complementing Group 5 (ERCC5) rs17655 polymorphism and head and neck cancer (HNC) susceptibility. However, these studies showed inconsistent results.

Aims: The aim of this study was to get a more comprehensive estimation of this association. Read More

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December 2018

First recognized n-butanol concentration may be simple and useful index for assessing olfactory dysfunction in geriatric patients.

Aging Clin Exp Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Otorhinolaryngology, Head and Neck Surgery, Chung-Ang University College of Medicine, 102, Heukseok-ro, Dongjak-gu, Seoul, 156-755, Republic of Korea.

The KVSSII is widely used to evaluate olfactory function in the Korean population. We evaluated the usefulness of the first recognized n-butanol concentration, which is obtained at the beginning part of KVSS II, in predicting olfactory dysfunction. Three hundred seventy two subjects were enrolled in our study. Read More

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December 2018

A Binding Potency Assay for Pritumumab and Ecto-Domain Vimentin.

Methods Mol Biol 2019 ;1904:401-415

Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, CA, USA.

Pritumumab, a natural human IgG1kappa mAb, was isolated from the regional lymph node of a patient with cervical cancer. This antibody has been reported to bind the cytoskeletal protein vimentin, and to cell surface expressed vimentin referred to as ecto-domain vimentin (EDV). Here, we report details of the development of a potency of binding assay for pritumumab as a prerequisite before pursuing clinical trials. Read More

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January 2019

Interfering with bromodomain epigenome readers as therapeutic option in mucoepidermoid carcinoma.

Cell Oncol (Dordr) 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, 1011 N University Ave, Room 2029C, Ann Arbor, MI, 48109-1078, USA.

Purpose: Emerging evidence indicates that bromodomains comprise a conserved class of epigenome readers involved in cancer development and inflammation. Bromodomains are associated with epigenetic modifications of gene transcription through interactions with lysine residues of histone tails. Particularly, the bromodomain and extra-terminal domain (BET) family member BRD4 has been found to be involved in the control over oncogenes, including c-MYC, and in the maintenance of downstream inflammatory processes. Read More

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December 2018

Oncocytic Sialolipoma of Parotid Gland: Case Report and Literature Review.

Head Neck Pathol 2018 Dec 11. Epub 2018 Dec 11.

Department of Ear, Nose and Throat, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT, UK.

Oncocytic sialolipoma is a very rare tumor of which only three cases have been reported. This entity is considered to be a variant of sialolipoma which harbours oncocytic nodules within a well-circumscribed lipomatous mass. We report a parotid mass in 73-year-old female that was difficult to diagnose in imaging and on biopsy. Read More

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December 2018
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