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J Orthop Surg Res 2021 May 5;16(1):298. Epub 2021 May 5.

Department of Neurosurgery, Dokuz Eylul University Medical Faculty, Izmir, Turkey.

Objective: We aimed to evaluate reliability, radiological outcomes, and the impacts of anterior cervical hybrid construction on the adjacent segments for the multilevel cervical degenerative disc disease (mCDDD) and spondylotic spinal stenosis (SSS).

Methods: A retrospective analysis was performed using data extracted from the medical files of 195 patients (105 males, 90 females; mean age: 47.7 years). Read More

Spine J 2021 Apr 30. Epub 2021 Apr 30.

St. Joseph's University Medical Center, Department of Orthopaedic Surgery, 703 Main Street, Paterson, NJ 07503. Electronic address:

Background Context: Although highlighted in joint arthroplasty studies, long-term outcomes between differing biomaterial composites, such as metal-on-metal (MoM) and metal-on-plastic (MoP) in anterior cervical disc replacement (ACDR) have not been thoroughly investigated.

Purpose: The purpose of this study was to evaluate the patient-reported clinical outcomes, overall reoperation rates, complications, and rates of ASD of MoM versus MoP artificial discs in two-level ACDR for the treatment of cervical DDD.

Study Design/setting: Meta-analysis and systematic review PATIENT SAMPLE: 980 patients (442 MoM, 538 MoP) across 7 studies OUTCOME MEASURES: Patient reported clinical outcomes (NDI, VAS-n, VAS-a), overall reoperation rates, complications and rates of ASD METHODS: A systematic search strategy of three electronic databases (PubMed, CINAHL Plus, and SCOPUS) was conducted utilizing terms related to two-level ACDR. Read More

J Surg Case Rep 2021 Apr 19;2021(4):rjab090. Epub 2021 Apr 19.

Department of Neurosurgery, Tufts University School of Medicine, Boston, MA, USA.

A 42-year-old woman from a medically underserved community in rural New England was referred by her primary care provider (PCP) for televisit during the coronavirus disease 2019 (COVID-19) pandemic following 2 years of chronic neck pain and numbness in her left hand that was initially concerning for demyelinating disease. Upon further evaluation, it was revealed that she had experienced a traumatic fall with a concussion and symptoms consistent with central cord syndrome but had refused magnetic resonance imaging (MRI) at her initial medical evaluation. On MRI conducted 1 month prior to neurosurgical evaluation she was found to have a disc bulge and 4-mm T2-hyperintense lesion at the C4-C5 level that was consistent with a chronic spinal cord injury secondary to spinal trauma with associated vertebrogenic injury. Read More

Spine (Phila Pa 1976) 2021 Apr 23. Epub 2021 Apr 23.

Department of Orthopaedic Surgery, University of Pittsburgh Medical Center Department of Neurosurgery, University of Pittsburgh Medical Center.

Study Design: Prospective cohort study.

Objective: To identify surgical factors that affect adjacent segment kinematics after anterior cervical discectomy and fusion (ACDF) as measured by biplane radiography.

Summary Of Background Data: Previous studies investigated the effect of surgical factors on spine kinematics as a potential etiology for adjacent segment disease (ASD). Read More

Neurochirurgie 2021 Apr 24. Epub 2021 Apr 24.

Faculty of medicine, University of Cartagena, Center for biomedical research (CIB), Cartagena, Colombia.

Introduction: Transcorporeal anterior cervical microforaminotomy is a motion-preserving surgery. It addresses directly to the prolapsed disc in contrast to posterior laminoforaminotomy and does not affect facet joints; in the transuncal approach, there is a chance of vertebral artery injury and it also decreases disc height; hence, may alter the motion of that segment.

Objective: Aim is to assess the outcome of surgery and its effectiveness. Read More

Global Spine J 2021 Apr;11(1_suppl):79S-88S

1500Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Study Design: Systematic review.

Objectives: To review the existing literature of prediction models in degenerative spinal surgery.

Methods: Review of PubMed/Medline and Embase databases was conducted to identify articles between January 1, 2000 and March 1, 2020 that reported prediction model performance for outcomes following elective degenerative spine surgery. Read More

J Am Vet Med Assoc 2021 May;258(9):999-1006

Case Description: 4 dogs, 7.5 to 10 years of age, were presented for evaluation of signs of chronic cervical pain and forelimb lameness secondary to cervical foraminal intervertebral disk protrusion (IVDP). All dogs were refractory to ≥ 2 weeks of conservative management including strict rest and pain management with anti-inflammatory drugs, methocarbamol, and gabapentin. Read More

Biomedicine (Taipei) 2020 1;10(3):33-40. Epub 2020 Sep 1.

Department of Clinical Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Radiculopathy due to lumbar or cervical disc disease is the most common chronic neuropathic pain in adults. The aim of present study was evaluation of low dose of sodium valproate (VPA) on radicular pain and determining VPA pharmacokinetics.

Materials And Methods: In this double blind randomized placebo control clinical study, 80 patients with established lumbar or cervical radicular pain, have been randomly allocated into two study groups: 40 have received sodium valproate 200 mg/day and Celecoxib 100 mg/day and acetaminophen 500 mg PRN as rescue medication, and second group has received placebo, Celecoxib and acetaminophen. Read More

World J Clin Cases 2021 Mar;9(9):2146-2152

Department of Orthopedics, The Third Medical Center, General Hospital of the Chinese People's Liberation Army, Beijing 100039, China.

Clinical studies have found that patients withcervical degenerative disease are usually accompanied by dizziness. Anterior cervical surgery can eliminate not only chronic neck pain, cervical radiculopathy or myelopathy, but also dizziness. Immunohistochemical studies show that a large number of mechanoreceptors, especially Ruffini corpuscles, are present in degenerated cervical discs. Read More

J Craniovertebr Junction Spine 2021 Jan-Mar;12(1):54-60. Epub 2021 Mar 4.

Department of Neurological Surgery, Policlinico Gaspare Rodolico University Hospital, Catania, Italy.

Background: Anterior cervical discectomy and fusion (ACDF) still represent the mainstream surgical approach in the treatment of degenerative cervical Degenerative Disc Disease (DDD), being a loss of mobility at the treated segment and adjacent segment diseases well-known complications. To overcome those complications, hybrid surgery (HS) incorporating ACDF and cervical disk arthroplasty is increasingly performed for DDD.

Methods: We retrospectively reviewed the clinical, surgical, and outcome data of 62 consecutive patients (male/female, 29/37) harboring cervical disk herniation with or without osteophytes, with radiculopathy with or without myelopathy, who underwent a cervical discectomy on two or more levels with the anterior approach with at least one disk prosthesis along with cage and plate or O Profile screwed plate. Read More

BMC Musculoskelet Disord 2021 Apr 9;22(1):340. Epub 2021 Apr 9.

Department of Orthopaedic Surgery, Tianjin Medical University General Hospital, Heping District, Tianjin, 300052, China.

Background: The plate-to-disc distance (PDD) is an important factor affecting the degeneration of adjacent segments after anterior cervical discectomy and fusion (ACDF). However, the most suitable PDD is controversial. This study examined the adjacent intervertebral disc stress, bone graft stress, titanium plate stress and screw stress to evaluate the biomechanical effect of different PDD on surgical segment and adjacent segment following C5/C6 ACDF. Read More

Cureus 2021 Mar 5;13(3):e13719. Epub 2021 Mar 5.

Neurological Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, USA.

Klippel-Feil syndrome (KFS) is characterized by failed segmentation of the cervical spine leading to inappropriately fused vertebral bodies. A 64-year-old male with a previous L5-S1 decompression presented with significant neck pain with radiation into the entire right upper extremity and hand. Imaging demonstrated fusion of the vertebral bodies at C2-3, C4-6, and C7-T1 with associated disc bulges at C3-4 and C6-7. Read More

Oper Neurosurg (Hagerstown) 2021 Apr 7. Epub 2021 Apr 7.

Background And Importance: Dural arteriovenous fistulas (dAVFs) are vascular abnormalities of the central nervous system that can cause a wide array of neurological dysfunction depending on their location, flow, and propensity to rupture. Symptomatic dAVFs at the cranio-cervical junction usually result in hemorrhage or cervical myelopathy. Distantly located dAVFs of the foramen magnum are a rare cause of thoracic intrinsic myelopathy. Read More

J Craniovertebr Junction Spine 2020 Oct-Dec;11(4):269-275. Epub 2020 Nov 26.

Center for NeuroTrauma Research, Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA.

Aims And Objectives: The human spine degenerates with age. Intervertebral disc degeneration occurs in the cervical spine. The objective of this study is to determine the effects of degenerative disc diseases on the range of motion (ROM) of the human cervical spinal column using a validated finite-element model. Read More

Eur J Neurol 2021 Apr 5. Epub 2021 Apr 5.

Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

Background And Purpose: Root and cord irritation from cervical spinal degenerative disease (SDD) may share clinical features with progressive multiple sclerosis (MS), so diagnostic overshadowing may occur. We hypothesized that cervical stenotic SDD is commoner in people with progressive MS, compared to controls.

Methods: A retrospective case-control study of 111 cases (56 with progressive MS and 55 age- and sex-matched controls) was conducted. Read More

Oxid Med Cell Longev 2021 16;2021:6699326. Epub 2021 Mar 16.

Bone Biomechanics Engineering Laboratory of Shandong Province, Neck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Shandong Medicinal Biotechnology Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250062, China.

Background: Intervertebral disc degeneration (IVDD) is one of the major causes of low back pain and motor deficiency. Nucleus pulposus (NP) degeneration plays a key role in the process of IVDD. The mechanical and biological interactions involved in NP degeneration have not been elucidated. Read More

Zhonghua Yi Xue Za Zhi 2021 Apr;101(13):945-949

Department of Orthopaedics, Beijing Key Labratory of Spinal Disease Research, Peking University Third Hospital, Beijing 100191, China.

To investigate parameters related to quantifying the amount of degeneration in preoperative patients to identify ideal indication of artificial cervical disc replacement (ACDR) in patient with a minimum of 10 years of follow-up data. From January 2004 to August 2008, a total of 44 patients underwent single level Bryan cervical disk replacement performed by the same group of surgeons were involved in this retrospective study, and all of the patients in this group had at least 10 years of follow-up data. Heterotopic ossification (HO) was graded in radiographic images by using the McAfee classification. Read More

Turk Neurosurg 2020 Sep 1. Epub 2020 Sep 1.

Erciyes University Faculty of Medicine.

Aim: Torticollis can originate from a wide variety of different disorders.

Objective: We aimed to investigate the underlying conditions in children with torticollis.

Material And Methods: Between May 2016 and December 2019, 24 patients (10 girls and 14 boys; mean age, 8 years) presenting with twisted neck, neck pain, weakness of extremities, imbalance, and gait disorder were evaluated retrospectively. Read More

Contrast Media Mol Imaging 2021 2;2021:8874990. Epub 2021 Mar 2.

Student Research Committee, Zabol University of Medical Science, Zabol, Iran.

Objective: The aim of this meta-analysis was to compare the diagnostic accuracy of 18F-FDG-PET/CT and MRI in predicting the tumor response in locally advanced cervical carcinoma (LACC) treated by chemoradiotherapy (CRT).

Method: This meta-analysis has been performed according to PRISMA guidelines. Systematic searches were conducted using PubMed and Embase databases for articles published from January 1, 2010, to January 1, 2020. Read More

J Orthop Case Rep 2020 Nov;10(8):93-96

Department of Spine, Indore Spine Centre, Indore, Madhya Pradesh, India.

Introduction: Lumbar disc herniation (LDH) is common manifestation of a degenerative disease involving tensile failure of the annulus to contain the gel like nuclear portion of the disc. Lumbar herniated discs can often cause muscle weakness, reduced motor function, and change in walking capacity and gait pattern.

Case Presentation: We present the case of an 18-year-old obese hypertensive male, with multiple level lumbar disc herniation, with a neurological deficit and failed conservative treatment. Read More

Zhonghua Yi Xue Za Zhi 2021 Mar;101(9):611-614

Department of Orthopaedics, Peking University Third Hospital, Beijing Key Laboratory of Spinal Disease Research, Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing 100191, China.

Heterotopic ossification(HO) and progressive bone formation(PBF) are main factors affecting the motion ability of target segments after cervical artificial disc replacement(CADR).The severity of pre-operative degeneration of target segment is the most important factor in the occurrence and progression of HO and PBF. The occurrence and progression of HO and PBF can be reduced basically through the improvement of degeneration evaluation system for intervertebral disc (including height, range of motion and osteophyte formation), uncovertebral joint and facet joint and standardization of surgical indication. Read More

J Food Prot 2021 Mar 5. Epub 2021 Mar 5.

Poultry Health Services Veterinary Surgeon Manor Court Veterinary Centre Church Street Tarvin UNITED KINGDOM Chester CH3 8EB.

Campylobacter is the leading cause of human bacterial diarrhoeal disease worldwide, with poultry meat products accounting for the majority of human cases. Recent surveys by the Food Standards Agency estimate the Campylobacter prevalence in fresh UK retail chicken to be 41.2%. Read More

Zhongguo Gu Shang 2021 Jan;34(1):20-5

Department of Pain, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen 518052, Guandong, China.

Objective: To evaluate the effectiveness and security of posterior percutaneous endoscopic cervical discectomy (PPECD) in the treatment of single level cervical spondylopathy with intraspinal ossification.

Methods: Twenty three patients with single level cervical spondylopathy with intraspinal ossification were treated by posterior percutaneous endoscopic cervical discectomy between August 2017 and July 2019. There were 16 males and 7 females, aged from 29 to 74 years old with an average of (50±13) years. Read More

Medicine (Baltimore) 2021 Feb;100(8):e23718

Centre of Precision Rehabilitation for Spinal Pain (CPR Spine), School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK.

Abstract: Pain as a result of cervical radiculopathy (CR) can be widespread, nondermatomal and individually specific, but the association between pain extent and other clinical features has never been explored. The objective of this study is to investigate whether pain extent relates to clinical variables including pain intensity in addition to health indicators including disability, general health, depression, somatic anxiety, coping strategies or self-efficacy.An observational cohort study was conducted. Read More

Medicine (Baltimore) 2021 Mar;100(9):e25012

Department of Physical Medicine and Rehabilitation, Pain Medicine Section, School of Medicine, Marmara University, Istanbul, Turkey.

Abstract: Epidural steroid injections (ESI) are commonly performed for the treatment of chronic cervical disc herniation (CDH). Although they are considered to be effective for both nociceptive and neuropathic types of pain, there is a lack of data regarding the impact of neuropathic pain (NP) and nociceptive pain components on treatment outcomes. The aim of this study is to compare the effectiveness of interlaminar epidural steroid injection (ILESI) between patients with predominantly NP and nociceptive pain due to CDH. Read More

AORN J 2021 03;113(3):237-251

Cervical disc disease includes chronic disc degeneration, stenosis, spondylosis, and disc herniation; providers initially treat these conditions conservatively through symptomatic care. When conservative measures fail, surgery may be indicated. It is important to explore all the surgical options available and the risks and benefits of each procedure. Read More

Spine (Phila Pa 1976) 2021 Feb 16. Epub 2021 Feb 16.

Neurosurgery Department, Novosibirsk Research Institute of Traumatology and Orthopaedics (NRITO) n.a.Ya.L.Tsivyan, Frunze str, 17, Novosibirsk, Russia.

Study Design: Longitudinal study of cervical MR in patients with degenerative disc disease (DDD).

Objective: To evaluate the evolution of the degenerative changes in the C2-C7 cervical segments and to assess the association MRI parameters with clinical symptoms after surgical treatment in patients with DDD.

Summary Of Background Data: The evolution of degenerative changes in the cervical spine is poorly understood. Read More

Open Med (Wars) 2021 22;16(1):161-168. Epub 2021 Jan 22.

Department of Rehabilitation Medicine, Gangnam Severance Hospital, Rehabilitation Institute of Neuromuscular Disease, Yonsei University College of Medicine, Seoul, Republic of Korea.

The purpose of this retrospective cross-sectional study was to examine the degrees of the cervical disc degeneration and the parameters of cervical sagittal balance in plain radiographs, representing cervical lordosis or head posture in subjects with posterior neck pain. A total of 113 patients with posterior neck pain with or without radiating pain were analyzed. The kinematic sagittal parameters of cervical radiographs were obtained at the occipito-cervical (O-C2) angle, sagittal Cobb's angles of C1-C2, C2-C7, and sagittal vertical axis (SVA) of C1-C7 and C2-C7. Read More

Cureus 2021 Feb 5;13(2):e13146. Epub 2021 Feb 5.

Otolaryngology-Head and Neck Surgery, King Abdulaziz University, Jeddah, SAU.

Background Rhinitis represents a global health problem, affecting 10%-20% of the population in Saudi Arabia. Topical intranasal corticosteroids (INCS) are widely used by otolaryngologists to treat patients with rhinitis for long periods. Although the effects of orally administered corticosteroids on intraocular pressure (IOP) and lens opacity are well established, the impact of INCS is not well defined. Read More

Int J Spine Surg 2020 Dec 29;14(6):916-923. Epub 2020 Dec 29.

Department of Orthopaedic Surgery, Singapore General Hospital, Singapore.

Background: Smoking is a known predictor of negative outcomes in spinal surgery. However, its effect on the functional outcomes and revision rates after ADR is not well-documented. This study is a retrospective analysis of prospectively collected data at a major tertiary center. Read More