6,274 results match your criteria Cervical Cancer* Obstetrics and Gynecology


TET1 promotes 5hmC-dependent stemness, and inhibits a 5hmC-independent epithelial-mesenchymal transition, in cervical precancerous lesions.

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

Translational Epigenetics Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

DNA hypermethylation is a driving force in carcinogenesis. However, the role of active DNA hypomethylation in cancer remains largely unknown. This process, facilitated by ten-eleven translocation methylcytosine dioxygenase 1 (TET1), which oxidizes 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), has never been studied in cervical cancer. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.01.033DOI Listing
February 2019

HPV vaccination in Japan: what is happening in Japan?

Expert Rev Vaccines 2019 Feb 15. Epub 2019 Feb 15.

a Deptartent of Gynecology, Tama-Hokubu Medical Center , Tokyo Metropolitan Health and Medical Treatment Corporation , Higashimurayama, Tokyo , Japan.

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https://www.tandfonline.com/doi/full/10.1080/14760584.2019.1
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http://dx.doi.org/10.1080/14760584.2019.1584040DOI Listing
February 2019
2 Reads

International radical trachelectomy assessment: IRTA study.

Int J Gynecol Cancer 2019 Feb 13. Epub 2019 Feb 13.

Oncological surgery, Clinica Astorga, Envigado, Colombia.

Background: Radical trachelectomy is considered a viable option for fertility preservation in patients with low-risk, early-stage cervical cancer. Standard approaches include laparotomy or minimally invasive surgery when performing radical trachelectomy.

Primary Objective: To compare disease-free survival between patients with FIGO (2009) stage IA2 or IB1 (≤2cm) cervical cancer who underwent open versus minimally invasive (laparoscopic or robotic) radical trachelectomy. Read More

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http://dx.doi.org/10.1136/ijgc-2019-000273DOI Listing
February 2019

Sentinel lymph node mapping using indocyanine green in patients with uterine and cervical neoplasms: restrictions of the method.

Arch Gynecol Obstet 2019 Feb 14. Epub 2019 Feb 14.

Department of Cardiology, Institute of Mother and Child, Warsaw, Poland.

Purpose: To establish the surgical, demographic and histopathological factors associated with inaccurate sentinel lymph nodes (SLNs) identification using indocyanine green (ICG) and near-infrared (NIR) fluorescence imaging in uterine and cervical neoplasms during both open and laparoscopic surgery.

Methods: We reviewed patients with atypical endometrial hyperplasia (AEH), clinical stage I and II cervical cancer or uterine malignancies who underwent primary surgery with SLN mapping between September 2015 and January 2018. An analysis of patients' demographics, tumor factors and surgical approach was conducted. Read More

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http://dx.doi.org/10.1007/s00404-019-05063-6DOI Listing
February 2019

MGL Ligand Expression Is Correlated to Lower Survival and Distant Metastasis in Cervical Squamous Cell and Adenosquamous Carcinoma.

Front Oncol 2019 29;9:29. Epub 2019 Jan 29.

Department of Pathology, Leiden University Medical Centre, Leiden, Netherlands.

Cervical cancer is the fourth most common cancer type in women worldwide and is characterized by a highly immune-suppressive microenvironment. Here, we describe aberrant glycosylation as a factor mediating this immunosuppressive microenvironment. Expression of a specific carbohydrate ligand for the immune-regulatory C-type lectin MGL was correlated to poor disease-specific survival and distant recurrences in squamous cell carcinoma (SCC) and adenosquamous carcinoma (ASC), the most common histological subtypes of cervical cancer. Read More

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http://dx.doi.org/10.3389/fonc.2019.00029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361794PMC
January 2019

The Urodynamics and Survival Outcomes of Different Methods of Dissecting the Inferior Hypogastric Plexus in Laparoscopic Nerve-Sparing Radical Hysterectomy of Type C: A Randomized Controlled Study.

Ann Surg Oncol 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, China.

Background: Little data exist about the impact of dissection methods on bladder function during nerve-sparing radical hysterectomy (NSRH). This randomized controlled trial compared the urodynamic and survival outcomes of different methods dissecting the inferior hypogastric plexus (IHP) during laparoscopic NSRH.

Methods: Eligible patients presenting with stage IB cervical cancer from 9 May 2013 to 27 October 2015 were randomized at a ratio of 1:1 and subjected to waterjet (study group) or traditional blunt (control group) dissection of the IHP for laparoscopic type C radical hysterectomy. Read More

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http://dx.doi.org/10.1245/s10434-019-07228-8DOI Listing
February 2019

MSK2 promotes proliferation and tumor formation in squamous cervical cancer via PAX8/RB-E2F1/cyclin A2 axis.

J Cell Biochem 2019 Feb 12. Epub 2019 Feb 12.

Department of Obstetrics and Gynecology, Heze Municipal Hospital, Heze, Shandong, China.

Patients with cervical cancer have abnormal cell proliferation and invasion after many years of latency. However, the precise mechanisms remain unclear. Mitogen- and stress-activated kinase 2 (MSK2) is a serine/threonine kinase which displays a phenotype that promotes tumor growth and metastasis in many different types of tumors. Read More

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http://dx.doi.org/10.1002/jcb.28421DOI Listing
February 2019

The distribution and prevalence of human papillomavirus in women in mainland China.

Cancer 2019 Feb 12. Epub 2019 Feb 12.

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.

We conducted a systematic review of the epidemiology of high-risk human papillomavirus (HPV) infections in mainland Chinese women to provide a general profile for the application and subsequent effectiveness evaluation of HPV vaccines. The PubMed, Web of Science, Medline (Ovid), China National Knowledge Infrastructure, and Wanfang databases were used for the literature search. The epidemiological studies published from January 2000 to June 2018 on high-risk HPVs in mainland Chinese women were investigated to systematically evaluate their epidemiological status. Read More

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http://doi.wiley.com/10.1002/cncr.32003
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http://dx.doi.org/10.1002/cncr.32003DOI Listing
February 2019
2 Reads

Survival outcomes of patients with cervical cancer and accompanying hydronephrosis: A systematic review of the literature.

Oncol Rev 2019 Jan 15;13(1):387. Epub 2019 Jan 15.

1 Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Greece.

Hydronephrosis is a sign of advanced stage disease in patients with cervical cancer. Its presence is believed to negatively affect the survival of patients. To date, however, consensus in this field is still lacking. Read More

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http://dx.doi.org/10.4081/oncol.2019.387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340308PMC
January 2019
1 Read

Perceptions of cervical cancer prevention on Twitter uncovered by different sampling strategies.

PLoS One 2019 11;14(2):e0211931. Epub 2019 Feb 11.

UCSF Center for Vulnerable Populations, Division of General Internal Medicine, Department of Medicine, UCSF, San Francisco, CA, United States of America.

Introduction: Cervical cancer prevention is possible through use of the HPV vaccine and Pap tests, yet the vaccine remains underutilized.

Methods: We obtained publicly-available Twitter data from 2014 using three sampling strategies (top-ranked, simple random sample, and topic model) based on key words related to cervical cancer prevention. We conducted a content analysis of 100 tweets from each of the three samples and examined the extent to which the narratives and frequency of themes differed across samples. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211931PLOS
February 2019
2 Reads

Low-Cost Instructional Apparatus to Improve Training for Cervical Cancer Screening and Prevention.

Obstet Gynecol 2019 Feb 4. Epub 2019 Feb 4.

Rice University, and the University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Cervical cancer remains one of the leading causes of cancer for women in medically underserved areas. This is in part due to a lack of trained clinicians to provide the necessary diagnosis and treatment of precancerous lesions to prevent cervical cancer. Increasing medical provider knowledge and skills is important for the early detection and prevention of cervical precancer and cancer in medically underserved areas of the United States and globally. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003140DOI Listing
February 2019
1 Read

Rethinking the next step after unexpected results associated with minimally invasive radical hysterectomy for early cervical cancer.

J Gynecol Oncol 2019 Jan 3. Epub 2019 Jan 3.

Department of Obstetrics and Gynecology, Kyung Hee University Hospital at Gangdong, Seoul, Korea.

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http://dx.doi.org/10.3802/jgo.2019.30.e43DOI Listing
January 2019
1 Read

Cost effectiveness analysis of HPV primary screening and dual stain cytology triage compared with cervical cytology.

J Gynecol Oncol 2018 Nov 8. Epub 2018 Nov 8.

Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Objectives: To assess the clinical and cost-effectiveness of human papillomavirus (HPV) primary screening triage with p16/Ki-67 dual stain cytology compared to cytology.

Methods: We conducted an Excel®-based budget impact model to estimate the preinvasive and invasive cervical cancer cases identified, mortality rate, direct medical costs, quality-adjusted life years (QALYs) and the incremental cost-effectiveness analysis of two strategies from the healthcare payer perspective. The study population is a cohort of women 30-65 years of age presenting for cervical screening. Read More

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http://dx.doi.org/10.3802/jgo.2019.30.e17DOI Listing
November 2018
1 Read

Evaluation of p16/Ki-67 dual staining in the detection of cervical precancer and cancer in China.

Cancer Epidemiol 2019 Feb 7;59:123-128. Epub 2019 Feb 7.

Department of Cancer Epidemiology, Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, 450008, China. Electronic address:

Background This study aimed to evaluate the clinical performance of p16/Ki-67 dual staining in the detection of cervical intraepithelial neoplasia grade 2 or 3 or worse (CIN2+/CIN3+) in Chinese women. Methods Cervical exfoliated cells were collected from 537 eligible women and were used for liquid-based cytology (LBC), p16/Ki-67 dual staining, and human papillomavirus (HPV) DNA testing. All women received colposcopy with biopsies taken at abnormal sites. Read More

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http://dx.doi.org/10.1016/j.canep.2018.12.013DOI Listing
February 2019
1 Read

Expression of the lncRNA ZFAS1 in cervical cancer and its correlation with prognosis and chemosensitivity.

Gene 2019 Feb 7. Epub 2019 Feb 7.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou 215100, Jiangsu, China. Electronic address:

Objective: To investigate the expression of the lncRNA ZFAS1 in cervical cancer and its relationship with patient prognosis and cervical cancer cell chemosensitivity.

Methods: The expression of ZFAS1 in cervical cancer tissues and cell lines was detected by qRT-PCR. The cervical cancer CaSki and the HeLa cell lines were transfected to be divided into Blank, siR-Control, and siR-ZFAS1 groups. Read More

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http://dx.doi.org/10.1016/j.gene.2019.01.025DOI Listing
February 2019

HPV-Chlamydial Coinfection, Prevalence, and Association with Cervical Intraepithelial Lesions: A Pilot Study at Mbarara Regional Referral Hospital.

J Cancer Epidemiol 2019 10;2019:9092565. Epub 2019 Jan 10.

PhD, (MUK), Makerere University, College of Health Science, P.O. Box 7072, Kampala, Uganda.

Background: Human Pappilloma Virus (HPV) is the necessary cause of cervical cancer. A number of risk factors are believed to influence the role of HPV in the development of cervical cancer. This is so because majority of HPV infections are cleared and only a few are able to result into cancer. Read More

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http://dx.doi.org/10.1155/2019/9092565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348791PMC
January 2019

SLN mapping in early-stage cervical cancer as a minimal-invasive triaging tool for multimodal treatment.

Eur J Surg Oncol 2019 Jan 30. Epub 2019 Jan 30.

Department of Obstetrics and Gynecology, University Hospital of Bern and University of Berne, Berne, Switzerland.

Background: To evaluate sensitivity, false negative rate and negative predictive value of the combination of sentinel lymph node (SLN) mapping and frozen section (FS) in triaging cervical cancer patients to a definitive chemo-radiotherapy.

Methods: A retrospective analysis of patients with histologically proven cervical cancer undergoing laparoscopic SLN mapping and frozen section of the SLNs followed by a completion radical hysterectomy, pelvic and/or paraarotic lymphadenectomy. Sensitivity, false negative rate and negative predictive value of the SLN mapping, of the frozen section and of the combination of the two in identifying micro- and macrometastases were calculated. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.01.184DOI Listing
January 2019
2 Reads

Gynecologic cancers and solid organ transplantation.

Am J Transplant 2019 Feb 6. Epub 2019 Feb 6.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Solid organ transplant (SOT) recipients have approximately 2-fold greater risk of developing and dying from a malignancy compared to the general population. Among the gynecologic cancers, including uterine, cervical, vaginal, vulvar, and ovarian, the HPV-related cancers are known to increase among women post-transplantation compared to women in the general population, but less is known about the risk of uterine and ovarian cancers. This review will provide an overview of the epidemiology of gynecologic cancers after SOT, as well as their pathophysiology, management, and specific risk factors. Read More

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http://dx.doi.org/10.1111/ajt.15292DOI Listing
February 2019
2 Reads

Current knowledge of and attitudes toward human papillomavirus-related disease prevention among Japanese: A large-scale questionnaire study.

J Obstet Gynaecol Res 2019 Feb 5. Epub 2019 Feb 5.

Department of Obstetrics and Gynecology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Aim: The human papillomavirus (HPV) vaccination rate in Japan fell to nearly 0% following widespread coverage of possible adverse events. Developing a next approach to promote the effective prevention of HPV-related diseases including cervical cancer (CC) in Japan requires comprehensive understanding of knowledge and attitudes regarding CC prevention, HPV infection and HPV vaccination among the population including laypersons and medical professions in Japan.

Methods: A questionnaire survey was administered in a wide variety of settings in Japan. Read More

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http://dx.doi.org/10.1111/jog.13929DOI Listing
February 2019
1 Read

Long non-coding RNA WT1-AS inhibits cell aggressiveness via miR-203a-5p/FOXN2 axis and is associated with prognosis in cervical cancer.

Eur Rev Med Pharmacol Sci 2019 Jan;23(2):486-495

Department of Obstetrics and Gynecology, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, China.

Objective: Substantial evidence has demonstrated that long non-coding RNAs (lncRNAs) play pivotal roles in tumorigenesis and tumor progression. The lncRNA Wilms tumor 1 Antisense RNA (WT1-AS) is a potential tumor suppressor in some types of cancers. The objective of this study was to evaluate the biological roles of WT1-AS in cervical cancer. Read More

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http://dx.doi.org/10.26355/eurrev_201901_16860DOI Listing
January 2019
2 Reads

Promoter hypermethylation of SOX11 promotes the progression of cervical cancer in vitro and in vivo.

Oncol Rep 2019 Feb 1. Epub 2019 Feb 1.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China.

The development of cervical cancer (CC) is a multi‑gene, multi‑step carcinogenic process that involves complex genetic and epigenetic mechanisms. SRY‑related HMG‑box gene 11 (SOX11) is a member of the SOX family of transcription factors with an emerging crucial role in the development of various tumor types. To elucidate the function of SOX11 in cervical carcinogenesis, the expression level of SOX11 during the development of human CC was analyzed by immunohistochemistry and western blot analysis. Read More

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http://dx.doi.org/10.3892/or.2019.6993DOI Listing
February 2019
2 Reads

Long noncoding RNA GIHCG functions as an oncogene and serves as a serum diagnostic biomarker for cervical cancer.

J Cancer 2019 1;10(3):672-681. Epub 2019 Jan 1.

Fuzong Clinical College of Fujian Medical University, Fuzhou, Fujian 350025, China.

Cervical cancer is the most common and lethal gynaecological tumor. Long noncoding RNAs (lncRNAs) have critical roles in various cancers, including cervical cancer. However, few studies investigated the diagnostic value of lncRNAs for cervical cancer. Read More

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http://dx.doi.org/10.7150/jca.28525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360414PMC
January 2019

Persuasive messaging for human papillomavirus vaccination by adolescent providers in a five-country multi-site study.

Int J Gynecol Cancer 2019 Feb 4;29(2):250-256. Epub 2019 Jan 4.

Department of Epidemiology, UNC Gillings School of Global Public Health, Chapel Hill, North Carolina, USA

Objective: Strong persuasive messaging by providers is a key predictor for patient acceptance of prophylactic human papillomavirus vaccination. We aimed to determine optimal messaging to promote human papillomavirus adolescent vaccination across different geographical sites.

Methods: Adolescent providers (n = 151) from Argentina, Malaysia, South Africa, South Korea, and Spain were surveyed on messages, family decision makers, and sources of communication to best motivate parents to vaccinate their adolescent daughters overall, and against human papillomavirus. Read More

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https://ijgc.bmj.com/lookup/doi/10.1136/ijgc-2018-000004
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http://dx.doi.org/10.1136/ijgc-2018-000004DOI Listing
February 2019
15 Reads

Limitations of simulation models for cervical cancer screening.

Lancet Oncol 2019 Feb;20(2):e68

Milken Institute School of Public Health, George Washington University, Washington, DC, USA; University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(19)30011-7DOI Listing
February 2019

Sarcopenia Is Not a Prognostic Factor of Outcome in Patients With Cervical Cancer Undergoing Concurrent Chemoradiotherapy or Radiotherapy.

Anticancer Res 2019 Feb;39(2):933-939

Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Background/aim: The objective of this study was to determine if sarcopenia was a predictor of poor prognosis in patients with cervical cancer (CC) undergoing concurrent chemoradiation therapy (CCRT) or radiation therapy (RT).

Materials And Methods: A total of 236 patients with CC undergoing CCRT or RT were retrospectively examined. We determined if clinical characteristics and survival were correlated with pretreatment sarcopenia, measured as psoas muscle index (PI) or skeletal muscle index (SMI). Read More

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http://dx.doi.org/10.21873/anticanres.13196DOI Listing
February 2019
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The role of miR-409-3p in regulation of HPV16/18-E6 mRNA in human cervical high-grade squamous intraepithelial lesions.

Antiviral Res 2019 Mar 31;163:185-192. Epub 2019 Jan 31.

RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic. Electronic address:

Cervical cancer is one of the most common malignancies in women. MicroRNAs (miRNAs) are involved in a variety of fundamental cellular processes, including carcinogenesis. The potential utilization of aberrantly expressed miRNAs as novel biomarkers in cervical cancer diagnostics is growing. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01663542183037
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http://dx.doi.org/10.1016/j.antiviral.2019.01.019DOI Listing
March 2019
1 Read

The burden of cervical cancer in Vietnam: Synthesis of the evidence.

Cancer Epidemiol 2019 Jan 30;59:83-103. Epub 2019 Jan 30.

Prince of Wales Clinical School, Faculty of Medicine, the University of New South Wales, Australia; Cancer Research Division, Cancer Council NSW, Australia; School of Public Health, University of Sydney, Australia. Electronic address:

There is currently no national cervical screening or HPV immunization program in Vietnam. This study aims to synthesize available data on the burden of disease and to project the burden of cervical cancer to 2049 if no major interventions are implemented. We reviewed published data sources on risk factors for HPV prevalence, high-grade lesions, cervical cancer incidence and mortality in Vietnam from 1990 to 2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18777821183026
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http://dx.doi.org/10.1016/j.canep.2018.11.008DOI Listing
January 2019
1 Read

Analysis of gastric-type mucinous carcinoma of the uterine cervix - An aggressive tumor with a poor prognosis: A multi-institutional study.

Gynecol Oncol 2019 Jan 29. Epub 2019 Jan 29.

Department of Obstetrics and Gynecology, Kurume University School of Medicine, Kurume, Japan.

Objective: Gastric-type mucinous carcinoma (GAS) is a novel variant of mucinous carcinoma of the uterine cervix. As shown in the original Japanese group description, in recent studies, GAS represents a more aggressive disease than the usual-type endocervical adenocarcinoma (UEA). Detailed clinicopathological features of this variant remain to be elucidated in a larger series of patients. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.01.022DOI Listing
January 2019
1 Read

A case of primary signet-ring cell carcinoma of the cervix containing full genome of human papillomavirus 16.

Indian J Pathol Microbiol 2019 Jan-Mar;62(1):146-148

Department of Obstetrics and Gynecology, School of Medicine, Fujita Health University, Tokyo 208-0011, Japan.

We herein present a case of primary signet-ring cell carcinoma of the cervix. Pelvic magnetic resonance imaging revealed a 38-mm cervical tumor, and computed tomography revealed no findings suggestive of distal metastasis or other tumor origins. Gastrointestinal endoscopy showed no abnormal findings. Read More

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http://www.ijpmonline.org/text.asp?2019/62/1/146/251259
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http://dx.doi.org/10.4103/IJPM.IJPM_507_17DOI Listing
February 2019
2 Reads
0.642 Impact Factor

Cervical Cancer and Its Precursors: A Preventative Approach to Screening, Diagnosis, and Management.

Prim Care 2019 Mar 22;46(1):117-134. Epub 2018 Dec 22.

Department of Obstetrics and Gynecology, University of California, Davis, Davis, CA, USA.

Cervical cancer affects the cells lining the cervix, most commonly occurring in the cells of the transformation zone. Screening for cervical cancer looks to detect preinvasive disease, allowing for intervention before invasive disease develops. an assessment of individual risk factors, Selection of screening method depends on patient age, her screening history and results, and resources available. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00954543183009
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http://dx.doi.org/10.1016/j.pop.2018.10.011DOI Listing
March 2019
9 Reads

Neoadjuvant Chemotherapy with Taxane and Platinum Followed by Radical Hysterectomy for Stage IB2-IIB Cervical Cancer: Impact of Histology Type on Survival.

J Clin Med 2019 Jan 30;8(2). Epub 2019 Jan 30.

Department of Obstetrics and Gynecology, Iwate Medical University, Iwate 020-0023, Japan.

The current study examined the histology-specific impact of neoadjuvant chemotherapy (NACT) with a taxane/platinum regimen on survival in women with locally-advanced cervical cancer who underwent radical hysterectomy. This nation-wide retrospective cohort study examined women with clinical stage IB2-IIB cervical cancer who received NACT prior to radical hysterectomy from 2004⁻2008 ( = 684). NACT type (taxane/platinum others) was correlated with survival based on histology: 511 squamous 173 non-squamous. Read More

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http://dx.doi.org/10.3390/jcm8020156DOI Listing
January 2019
1 Read

Current management of cervical cancer in Poland-Analysis of the questionnaire trial for the years 2002-2014 in relation to ASCO 2016 recommendations.

PLoS One 2019 31;14(1):e0209901. Epub 2019 Jan 31.

Department of Gynecology and Obstetrics, Jagiellonian University Medical College, Krakow, Poland.

Objectives: To assess the survival of patients with cervical cancer (CC). Since the recommendations concerning cervical cancer management adopted by Polish medical societies do not differ significantly from the ESGO or non-European guidelines, and the fact that evaluation of the system for CC treatment in Poland, as well as the mortality rate of Polish women with CC, which is 70% higher than the average for European Union (EU) countries, justifies the hypothesis that treatment of CC in Poland deviates from the Polish and international recommendations. This article puts forward the current management of cervical cancer in Poland and discusses it in the context of ASCO guidelines. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209901PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354992PMC
January 2019
4 Reads

SMAD3 inducing the transcription of  STYK1 to promote the EMT process and improve the tolerance of ovarian carcinoma cells to paclitaxel.

J Cell Biochem 2019 Jan 30. Epub 2019 Jan 30.

Department of Obstetrics and Gynecology, Peking University Frist Hospital, Beijing, China.

Objective: To figure out the relationship between SMAD3 and serine-threonine tyrosine kinase (STYK1) in ovarian carcinoma cell's paclitaxel resistance.

Methods: The quantitative reverse transcription-polymerase chain reactpostion and Western blot analysis were used to analyze RNA and protein content of SMAD3 and STYK1, respectively. The chromatin immunoprecipitation assay was used to confirm the binding site of SMAD3 to the STYK1 promoter region. Read More

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http://dx.doi.org/10.1002/jcb.28371DOI Listing
January 2019
1 Read

Neoadjuvant intra-arterial chemotherapy using an original four-lumen double-balloon catheter for locally advanced uterine cervical cancer.

Oncotarget 2018 Dec 28;9(102):37766-37776. Epub 2018 Dec 28.

Department of Obstetrics and Gynecology, Osaka Medical College, Takatsuki, Japan.

Objective: We report a balloon-occluded arterial infusion therapy with an original four-lumen double-balloon catheter (4L-DB) which allows for the efficient injection of an anticancer agent at a high concentration to the target spot for patients with locally advanced uterine cervical cancer.

Methods: One hundred and forty-three patients with locally advanced cervical cancer treated with neoadjuvant intra-arterial chemotherapy (NAIAC) or a primary radical hysterectomy (PRH) were retrospectively assessed. The patients in the NAIAC group received irinotecan 70 mg/m2 intravenously on day 1 and 8 and cisplatin 70 mg/m2 intra-arterially using the 4L-DB on day 2 of a 21-day course, and two courses were performed in principle. Read More

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http://dx.doi.org/10.18632/oncotarget.26518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340883PMC
December 2018
1 Read

Estimating the epidemiological impact and cost-effectiveness profile of a nonavalent hpv vaccine in Spain.

Hum Vaccin Immunother 2019 Jan 30. Epub 2019 Jan 30.

b Medical Department , MSD Spain , Madrid , Spain.

Human papillomavirus (HPV) is one of the main causes of infection-related cancer. The bivalent vaccine (2vHPV) (16/18) and quadrivalent (6/11/16/18) HPV vaccine (4vHPV) have been included in the Spanish vaccination calendar since 2007. The new nonavalent HPV vaccine (9vHPV), approved in Europe in 2015, includes nine HPV types 6/11/16/18/31/33/45/52/58 and has been available in Spain since May 2017. Read More

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http://dx.doi.org/10.1080/21645515.2018.1560770DOI Listing
January 2019

miR-503 expression is downregulated in cervical cancer and suppresses tumor growth by targeting AKT2.

J Cell Biochem 2019 Jan 29. Epub 2019 Jan 29.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Previous studies have reported that microRNAs function as key regulators in tumor development and progression. This study aims to investigate the functional effects of miR-503 expression in cervical cancer (CC) progression. We detected the expression of miR-503 in CC tissues and cell lines using quantitative real-time polymerase chain reaction. Read More

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http://doi.wiley.com/10.1002/jcb.28099
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http://dx.doi.org/10.1002/jcb.28099DOI Listing
January 2019
5 Reads

Cervical cancer-instructed stromal fibroblasts enhance IL-23 expression in dendritic cells to support expansion of Th17 cells.

Cancer Res 2019 Jan 29. Epub 2019 Jan 29.

Institute of Virology, Saarland University Medical Center.

Persistent infection with high-risk human papillomavirus (HPV) is a prerequisite for the development of cervical cancer. HPV-transformed cells actively instruct their microenvironment, promoting chronic inflammation and cancer progression. We previously demonstrated that cervical cancer cells contribute to T-helper-17 (Th17) cell recruitment, a cell type with pro-tumorigenic properties. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-18-1913DOI Listing
January 2019

Suppression of miR-93-5p inhibits high-risk HPV-positive cervical cancer progression via targeting of BTG3.

Hum Cell 2019 Jan 28. Epub 2019 Jan 28.

Department of Gynecology, Second Hospital of Hebei Medical University, No.215, HePing West Road, Shijiazhuang, 050000, Hebei, China.

This study explores the role of miR-93-5p in high-risk HPV-positive (HR-HPV) cervical cancer by targeting of BTG3. Cervical tissues were collected from 332 patients with conditions of chronic cervicitis (n = 42), low-grade cervical intraepithelial neoplasia (CIN I, n = 51), CIN II (n = 49), CIN III (n = 43), cervical cancer (n = 90), and normal cervical tissues (n = 57). HR-HPV DNA was detected by Hybrid Capture 2, and the expressions of miR-93-5p and BTG3 were determined by qRT-PCR and Western blot. Read More

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http://dx.doi.org/10.1007/s13577-018-00225-1DOI Listing
January 2019

Management and treatment of cervical intraepithelial neoplasia in the Netherlands after referral for colposcopy.

Acta Obstet Gynecol Scand 2019 Jan 28. Epub 2019 Jan 28.

Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands.

Introduction: The aim of this study was to describe trends in diagnosis and treatment of women referred from screening with cervical intraepithelial neoplasia (CIN) in the Netherlands, compare this to national guidelines and identify potential areas for improvement for the new primary high-risk HPV screening program.

Material And Methods: We conducted a population-based cohort study using data from Dutch pathology archive. Women aged 29 to 63 years who took part in the Dutch cervical screening program between 1 January 2005 to 31 December 2014 were selected. Read More

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http://dx.doi.org/10.1111/aogs.13547DOI Listing
January 2019
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Patterns of recurrence and prognosis in locally advanced FIGO stage IB2 to IIB cervical cancer: Retrospective multicentre study from the FRANCOGYN group.

Eur J Surg Oncol 2018 Dec 30. Epub 2018 Dec 30.

Department of Gynaecology and Obstetrics, Tenon University Hospital, Assistance Publique des Hôpitaux de Paris (AP-HP), University Pierre and Marie Curie, Paris 6, Institut Universitaire de Cancérologie (IUC), 4 rue de la Chine, 75020, Paris, France; INSERM UMR_S_938, University Pierre et Marie Curie, Paris 6, 27 rue de Chaligny, 75012, Paris, France.

Introduction: Evidence-based data describing patterns of recurrence and prognosis in women with FIGO stage IB2 to IIB locally advanced cervical cancer (LACC) are scarce. The purpose of this study was to analyse patterns of recurrence in LACC and their correlation with prognosis, depending on FIGO stage, lymph node (LN) status and treatment modalities. The endpoints of this study were the type of recurrence (locoregional or distant, and time to recurrence), the recurrence free survival, the overall survival and the cumulative incidence for both locoregional and distant recurrence. Read More

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http://dx.doi.org/10.1016/j.ejso.2018.11.014DOI Listing
December 2018
3 Reads

(At Least) Once in Her Lifetime: Global Cervical Cancer Prevention.

Obstet Gynecol Clin North Am 2019 Mar;46(1):107-123

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Belfer 1308A, Bronx, NY 10461, USA.

Cervical cancer disproportionately burdens lower-resourced settings, in which nearly 90% of cervical cancer and cervical cancer-related deaths occur. Targeting human papillomavirus (HPV) by prophylactic HPV vaccination in young adolescent girls and HPV-based screening in mid-adult women offers the most cost-effective strategy to reduce cervical cancer burden worldwide and mitigate the health disparities in cervical cancer burden between low-resourced and high-resourced settings. Political and social will, along with the necessary financial investments, will be necessary to realize the opportunity for significant global reductions in the cervical cancer burden. Read More

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http://dx.doi.org/10.1016/j.ogc.2018.09.007DOI Listing

Screening capacity and cost-effectiveness of the human papillomavirus test versus cervicography as an adjunctive test to Pap cytology to detect high-grade cervical dysplasia.

Eur J Obstet Gynecol Reprod Biol 2019 Jan 17;234:112-116. Epub 2019 Jan 17.

Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, Republic of Korea.

Objective: This study compared the screening capacities and cost-effectiveness of the human papillomavirus (HPV) test versus cervicography as an adjunctive test to Papanicolaou (Pap) cytology to detect high-grade cervical neoplasia in Korea, a country with a high prevalence of cervical cancer.

Study Design: Of 33,531 Korean women who underwent cervicography as a screening test for cervical cancer between January 2015 and December 2016, we retrospectively analyzed the records of 4117 women who simultaneously or subsequently underwent Pap cytology, an HPV test, cervicography, and colposcopically directed biopsy. At a threshold of cervical intraepithelial neoplasia grade 2 or worse (CIN2+), based on colposcopic biopsy, we compared the diagnostic capacities and cost-effectiveness of these screening tools. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.01.008DOI Listing
January 2019
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1.627 Impact Factor

Efficacy of robotic radical hysterectomy for cervical cancer compared with that of open and laparoscopic surgery: A separate meta-analysis of high-quality studies.

Medicine (Baltimore) 2019 Jan;98(4):e14171

Department of Obstetrics and Gynecology, Women's Hospital, Zhejiang University of Medicine, Hangzhou, Zhejiang Province, China.

Background: To perform a meta-analysis of high-quality studies comparing robotic radical hysterectomy (RRH) vs laparoscopic radical hysterectomy (LRH), and open radical hysterectomy (ORH) for the treatment of cervical cancer.

Methods: A systematic search of PubMed, Embase, Cochrane Library, and Web of Science was performed to identify studies that compared RRH with LRH or ORH. The selection of high-quality, nonrandomized comparative studies was based on a validated tool (methodologic index for nonrandomized studies) since no randomized controlled trials have been published. Read More

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http://dx.doi.org/10.1097/MD.0000000000014171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358398PMC
January 2019

Non-human Papillomavirus Cervical Mucinous Adenocarcinoma in a Phenotypic Male with Congenital Adrenal Hyperplasia.

Cureus 2018 Nov 18;10(11):e3607. Epub 2018 Nov 18.

Obstetrics and Gynecology, University of Minnesota, Minneapolis, USA.

A majority of cervical cancers are caused by human papillomavirus (HPV); however, HPV-negative cervical cancers exist and, though rare, are more aggressive. No prior reports examine HPV-negative cancer of the cervix in a female pseudohermaphrodite with congenital adrenal hyperplasia (CAH). This is a case of a 78-year-old phenotypic male with hypospadias and absent testicles who presented with urinary retention and urosepsis. Read More

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http://dx.doi.org/10.7759/cureus.3607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338395PMC
November 2018

Correction: Control of PD-L1 expression by miR-140/142/340/383 and oncogenic activation of the OCT4-miR-18a pathway in cervical cancer.

Oncogene 2019 Jan 24. Epub 2019 Jan 24.

Department of Women's Health Educational System, Hokkaido University School of Medicine, Hokkaido University, Sapporo, 0608638, Japan.

In Fig. 2d, the Western blot panels representing GAPDH endogenous loading controls were improperly cropped, leading to four lanes of GAPDH endogenous loading controls for five lanes of PD-L1 protein expressions. The authors apologize for any confusion that this error may have caused. Read More

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http://dx.doi.org/10.1038/s41388-019-0677-xDOI Listing
January 2019
8.459 Impact Factor

Genetic variants of the dUTPase-encoding gene DUT increase HR-HPV infection rate and cervical squamous cell carcinoma risk.

Sci Rep 2019 Jan 24;9(1):513. Epub 2019 Jan 24.

Women's Reproductive Health Key Laboratory of Zhejiang Province, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310006, P. R. China.

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) is involved in the repair and prevention of uracil misincorporations into DNA. Maintenance of DNA integrity is critical for cancer prevention. Many studies have identified susceptibility loci and genetic variants in cervical cancer. Read More

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http://dx.doi.org/10.1038/s41598-018-36757-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345750PMC
January 2019

Prevalence of human papillomavirus-related diseases in the Republic of Korea: a cross-sectional study.

Sex Transm Infect 2019 Jan 24. Epub 2019 Jan 24.

Department of Cancer Control and Population Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea

Objective: We aimed to evaluate trends in the prevalence of human papillomavirus (HPV)-related diseases in the era before the introduction of organised HPV vaccination programmes in the Republic of Korea.

Methods: This cross-sectional study used National Health Insurance Service data from 2002 to 2015 and included participants who were diagnosed with the following HPV-related diseases (codes from the International Classification of Diseases, 10th Revision): genital warts (A63.0); cancer in the head and neck (C00-C10), anus (C21), vulva (C51), vagina (C52), cervix uteri (C53) and penis (C60); carcinoma in situ (CIS) of the lip/oral cavity/pharynx (D00. Read More

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http://sti.bmj.com/lookup/doi/10.1136/sextrans-2018-053742
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http://dx.doi.org/10.1136/sextrans-2018-053742DOI Listing
January 2019
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The Impact of Triage for Atypical Squamous Cells of Undetermined Significance with Human Papillomavirus Testing in Cervical Cancer Screening in Japan

Asian Pac J Cancer Prev 2019 Jan 25;20(1):81-85. Epub 2019 Jan 25.

Department of Obstetrics and Gynecology, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan. Email:

Background: One of the features of cervical cancer screening using the combination of cytology and human papillomavirus (HPV) testing is the triage for atypical squamous cells of undetermined significance (ASC-US). The effectiveness of the triage has been recognized widely. However, there are few reports evaluating this triage process in Japan. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.1.81DOI Listing
January 2019
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CRISPR/Cas9-mediated cervical cancer treatment targeting human papillomavirus E6.

Oncol Lett 2019 Feb 10;17(2):2197-2206. Epub 2018 Dec 10.

Division of Genetic Therapeutics, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi 329-0498, Japan.

High-risk human papillomavirus (HPV) is a common cause of cervical cancer. HPV E6 oncoprotein promotes the degradation of host tumor suppressor gene , leading to the development of tumors. Therapeutic strategies that specifically target E6, which is constitutively expressed in tumors and is not present in normal tissues, may be highly effective and safe. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9815
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http://dx.doi.org/10.3892/ol.2018.9815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341785PMC
February 2019
2 Reads