7,316 results match your criteria Cervical Cancer* Obstetrics and Gynecology


Detection of TP53 Clonal Variants in Papanicolaou Test Samples Collected up to 6 Years Prior to High-Grade Serous Epithelial Ovarian Cancer Diagnosis.

JAMA Netw Open 2020 Jul 1;3(7):e207566. Epub 2020 Jul 1.

Department of Obstetrics and Gynecology, Università degli Studi Milano-Bicocca, San Gerardo Hospital, Monza, Italy.

Importance: The low 5-year survival rate of women with high-grade serous epithelial ovarian cancer (HGS-EOC) is related to its late diagnosis; thus, improvement in diagnosis constitutes a crucial step to increase the curability of this disease.

Objective: To determine whether the presence of the clonal pathogenic TP53 variant detected in matched primary tumor biopsies can be identified in DNA purified from Papanicolaou test samples collected from women with HGS-EOC years before the diagnosis.

Design, Setting, And Participants: This cohort study was conducted among a single-center cohort of women with histologically confirmed diagnosis of HGS-EOC recruited at San Gerardo Hospital, Monza, Italy, from October 15, 2015, to January 4, 2019. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.7566DOI Listing

The Regulatory Role of circRNA_101308 in Cervical Cancer and the Prediction of Its Mechanism.

Cancer Manag Res 2020 22;12:4807-4815. Epub 2020 Jun 22.

Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan 250012, People's Republic of China.

Purpose: Accumulating evidence indicates that circular RNAs (circRNAs) are closely involved in canceration and cancer progression. However, the role of circRNAs in cervical cancer (CC) is largely unknown. Here, we characterized the role of circRNA_101308 in CC. Read More

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http://dx.doi.org/10.2147/CMAR.S242615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319513PMC

CFTR Regulates the Proliferation, Migration and Invasion of Cervical Cancer Cells by Inhibiting the NF-κB Signalling Pathway.

Cancer Manag Res 2020 18;12:4685-4697. Epub 2020 Jun 18.

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Chengdu, Sichuan, People's Republic of China.

Background: The cystic fibrosis transmembrane conductance regulator (CFTR) and nuclear factor κB (NF-κB) signalling pathways are currently regarded as co-regulators of the occurrence of cervical cancer. However, the detailed mechanism of CFTR- and NF-κB-mediated effects in cervical cancer remains to be elucidated. This study aimed to investigate the mechanism by which CFTR and NF-κB influence the development of cervical cancer. Read More

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http://dx.doi.org/10.2147/CMAR.S252296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308183PMC

Characteristics and Treatments of Patients Aged 65 Years or Over with Cervical Cancer.

Clin Interv Aging 2020 3;15:841-851. Epub 2020 Jun 3.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.

Purpose: Although the mortality of elderly women with cervical cancer is high, their characteristics and prognosis have not attracted sufficient attention. This study aims to clarify the prognostic factors of cervical cancer patients aged ≥65.

Patient And Methods: The incidences and characteristics of patients diagnosed with cervical cancer (aged ≥65 and <65) during 2004-2015 were obtained through the Surveillance, Epidemiology, and End Results Program (SEER) database. Read More

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http://dx.doi.org/10.2147/CIA.S255305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293398PMC

Hysterectomy for Recurrent/Residual Cervical Cancer Following Definitive Radiotherapy.

In Vivo 2020 Jul-Aug;34(4):2173-2177

Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.

Background/aim: Radical hysterectomy has been used for local recurrent or persistent (LR) cervical cancer after radiotherapy (RT), but the rate of serious complications is high and tolerance is low. This study determined the efficacy, safety, and prognostic factors of adjuvant simple hysterectomy in LR cervical cancer post-RT.

Patients And Methods: A total of 21 patients who underwent hysterectomy for LR cervical cancer post-RT in our Department between May 2007 and September 2018 were included in the study. Read More

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http://dx.doi.org/10.21873/invivo.12026DOI Listing

Radical Hysterectomy for Cervical Cancer in Patients With Uterine Prolapse.

In Vivo 2020 Jul-Aug;34(4):2073-2078

Department of Surgery, "Ponderas" Academic Hospital, Bucharest, Romania.

Background/aim: Association between cervical cancer and uterine prolapse represents a scarce eventuality. This is a case series of 11 patients diagnosed with different stages of cervical cancer in association with uterine prolapse.

Patients And Methods: Between 2014 and 2020, 11 patients were diagnosed with cervical cancer on prolapsed uterine cervix. Read More

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http://dx.doi.org/10.21873/invivo.12010DOI Listing

Cervical Cancer Mortality in East-Central European Countries.

Int J Environ Res Public Health 2020 Jun 28;17(13). Epub 2020 Jun 28.

Department of Oncologic Gynecology and Obstetrics, The Center of Postgraduate Medical Education, 00-416 Warsaw, Poland.

Changes that took place in Europe in the early 1990s had an impact on health-associated issues. They were an impulse for the changes in healthcare systems and, consequently, also for the changes in cancer control programmes. Those changes also had an effect on mortality rates due to cervical cancer (CC). Read More

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http://dx.doi.org/10.3390/ijerph17134639DOI Listing

Insulin growth factor-1 pathway in cervical carcinoma cancer stem cells.

Mol Cell Biochem 2020 Jun 29. Epub 2020 Jun 29.

Molecular Pathology Laboratory, Department of Cytology & Gynec. Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, PIN-160023, India.

Cancer stem cells (CSC) drive tumour progression and are implicated in relapse and resistance to conventional cancer therapies. Identification of differentially expressed genes by gene expression (GEP) profiling may help identify the differentially activated signalling pathways in cancer stem cells as opposed to bulk tumour cells which will provide new insights into cancer stem cell biology and aid in identification of novel therapeutic targets. Our study focused on the inhibition of CSC from cervical cancer cell lines by targeting insulin-like growth factor (IGF), which was identified by differential GEP. Read More

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http://dx.doi.org/10.1007/s11010-020-03807-6DOI Listing

A practical method of using the anatomical space of the vesicouterine ligament for laparoscopic radical hysterectomy: a retrospective cohort study.

J Int Med Res 2020 Jun;48(6):300060520926857

Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Objective: To investigate the practicality of a new method using anatomical spaces for performing standard laparoscopic radical hysterectomy (LRH) without ureteral injury in patients with cervical cancer.

Methods: Clinicopathological characteristics and perioperative complications were retrospectively analysed in 440 patients with stages IB1 to IIB cervical cancer. The patients were assigned to two of the following groups: LRH by our method of using anatomical landmarks (anatomical space group, n = 217) and the traditional method (traditional group, n = 223). Read More

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http://dx.doi.org/10.1177/0300060520926857DOI Listing

CDKN2A inhibits cell proliferation and invasion in cervical cancer through LDHA-mediated AKT/mTOR pathway.

Clin Transl Oncol 2020 Jun 27. Epub 2020 Jun 27.

Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan, 430071, Hubei, People's Republic of China.

Purpose: The current study aims to explore the effects of CDKN2A on cell proliferation and cycle, and investigate the underlying mechanisms.

Methods: Expression of CDKN2A in cervical cancer cell lines was evaluated by real-time quantitative PCR (RT-qPCR) and western blotting. Apoptotic rate was detected by Annexin V assay. Read More

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http://dx.doi.org/10.1007/s12094-020-02409-4DOI Listing

Prognostic factors influencing pelvic, extra-pelvic, and intraperitoneal recurrences in lymph node-negative early-stage cervical cancer patients following radical hysterectomy.

Eur J Obstet Gynecol Reprod Biol 2020 Jun 16;252:94-99. Epub 2020 Jun 16.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Republic of Korea.

Objective: The aim of this study was to evaluate the clinicopathologic factors influencing pelvic, extra-pelvic, and intraperitonal recurrences and survival in patients with lymph node-negative early-stage cervical cancer treated with abdominal/laparoscopic/robotic radical hysterectomy (ARH/LRH/RRH).

Study Design: We retrospectively reviewed clinicopathologic data of 342 patients with FIGO stage IB-IIA cervical cancer (2018 FIGO staging) treated with RH and retroperitonal lymphadenectomy between February 2000 and November 2018. Several clinicopathologic factors such as surgical methods including LRH/RRH-vaginal colpotomy (VC) and LRH/RRH-intracorporeal colpotomy (IC), surgical resection margin, and parametrial/endomyometrial infiltration were selected. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.06.030DOI Listing

Modeling for Predictors of Knowledge Score on Etiology and Prevention Strategies for Cervical Cancer Among Women of Reproductive Age in Ibadan.

JCO Glob Oncol 2020 Jun;6:892-903

Department of Obstetrics and Gynecology, Faculty of Clinical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Purpose: Poor knowledge regarding cervical cancer in at-risk populations directly affects health-seeking behavior and is associated with high mortality among women with cervical cancer. This study aims to evaluate the knowledge of women regarding the causes, risk factors, and prevention strategies of cervical cancer.

Methods: A multistage cross-sectional study of 1,002 women of reproductive age (18-49 years) in Ibadan was conducted. Read More

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http://dx.doi.org/10.1200/GO.20.00086DOI Listing

Differences in Treatment Outcomes and Prognosis between Elderly and Younger Patients Receiving Definitive Radiotherapy for Cervical Cancer.

Int J Environ Res Public Health 2020 Jun 23;17(12). Epub 2020 Jun 23.

Department of Radiation Oncology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan.

The aim was to compare the clinical outcomes and prognostic factors of cervical cancer between elderly and younger women, and to explore which treatment strategy is more appropriate for elderly patients. We retrospectively reviewed patients with cervical cancer receiving definitive radiotherapy (RT) between 2007 and 2016, and divided them into two age groups: age < 70 vs. age ≥ 70. Read More

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http://dx.doi.org/10.3390/ijerph17124510DOI Listing

Low-dose naltrexone inhibits the epithelial-mesenchymal transition of cervical cancer cells in vitro and effects indirectly on tumor-associated macrophages in vivo.

Int Immunopharmacol 2020 Jun 22;86:106718. Epub 2020 Jun 22.

Department of Immunology, School of Basic Medical Science, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, Liaoning Province, China. Electronic address:

The metastasis of cervical cancer has always been a clinical challenge. We investigated the effects of low-dose naltrexone (LDN) on the epithelial mesenchymal transition of cervical cancer cells in vitro as well as its influence on macrophage polarization and associated cytokines in vivo. The results suggested that LDN supressed the proliferation, migration and invasion abilities and promote their apoptosis in Hela cells, whereas the opioid growth factor receptor (OGFr) silenced significantly reversed these effects in vitro. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106718DOI Listing
June 2020
2.472 Impact Factor

Evaluation of the concordance in HPV type between self- and physician-collected samples using a brush-based device and a PCR-based HPV DNA test in Japanese referred patients with abnormal cytology or HPV infection.

Int J Clin Oncol 2020 Jun 24. Epub 2020 Jun 24.

Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji-cho, Fukui, 910-1193, Japan.

Background: To adopt HPV self-sampling in Japan, we assessed the concordance between self- and physician-collected human papillomavirus (HPV) samples from Japanese patients and examined the performance of HPV self-sampling for cervical intraepithelial neoplasia grade 2 or worse (CIN2+).

Methods: Patients who had previously tested negative for intraepithelial lesions or malignancy/HPV-positive, and patients with atypical squamous cells of undetermined significance or worse (ASCUS+) cytology were eligible for this cross-sectional study. Participants performed HPV self-sampling using an Evalyn brush, which was submitted at the Fukui Prefectural Health Care Association. Read More

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http://dx.doi.org/10.1007/s10147-020-01727-5DOI Listing

DNA methylation for cervical cancer screening: a training set in China.

Clin Epigenetics 2020 Jun 23;12(1):91. Epub 2020 Jun 23.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Shuaifuyuan No. 1, Dongcheng District, Beijing, 100730, China.

Background: Despite rapid improvements in DNA methylation tools for cervical cancer screening, few robust, exploratory studies have been performed using the combination of two host genes, EPB41L3 and JAM3, newly developed assays.

Methods: A review of abnormal liquid-based cytology and/or high-risk human papillomavirus (hrHPV) data from outpatient clinics in the study center from March 2018 to March 2019 was performed. Eligible patients with definitive histological pathology results were included, and their residual cytology samples were assessed for EPB41L3 and JAM3 methylation. Read More

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http://dx.doi.org/10.1186/s13148-020-00885-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310541PMC

Evaluation of Liquid Versus Dry Specimen Transport With a Newly Validated Isothermal Amplification High-Risk Human Papillomavirus Assay.

J Low Genit Tract Dis 2020 Jul;24(3):243-246

Preventive Oncology International Inc., Cleveland, OH.

Objective: The aim of the study was to determine whether the proportion of positive high-risk human papillomavirus (HR-HPV) tests in endocervical specimens transported dry differs from paired specimens transported in liquid media.

Methods: Five hundred women aged of 30 to 55 years were recruited, Shanxi Bethune Hospital, China. Two samples were collected from the endocervix per patient, one placed into empty vial, the other into a liquid transport solution. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000546DOI Listing

Do High Rates of Atypical Glandular Cells Correlate With Higher Incidence of Disease in a Large Safety Net Hospital.

J Low Genit Tract Dis 2020 Jun 17. Epub 2020 Jun 17.

Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA.

Objective: The aim of the study was to describe the incidence and correlates of atypical glandular cell (AGC) Pap tests in a low socioeconomic status, underserved population.

Materials And Methods: Medical records of patients with AGC Pap tests at a single institution were reviewed from January 2013 to August 2019. Baseline characteristics were extracted including age, body mass index, birth control, abnormal uterine bleeding, and human papillomavirus (HPV). Read More

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http://dx.doi.org/10.1097/LGT.0000000000000556DOI Listing
June 2020
1.110 Impact Factor

Associations between the expression of SCCA, MTA1, P16, Ki-67 and the infection of high-risk HPV in cervical lesions.

Oncol Lett 2020 Jul 18;20(1):884-892. Epub 2020 May 18.

Department of Obstetrics and Gynecology, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei 063000, P.R. China.

The application of detection technologies for human papillomavirus (HPV) has increased the resection rate for cervical intraepithelial neoplasia and early cervical cancer types. However, a large number of patients still present with advanced cervical cancer upon diagnosis. Therefore, to find a marker for the early diagnosis of cervical cancer, the present study investigated the expression profiles of squamous cell carcinoma antigen (SCCA), tumor metastasis related factor-1 (MTA1), the multiple tumor suppressor gene P16, and the nucleus-associated antigen Ki-67 in cervical lesions, and evaluated the association between the four proteins and the infection of high-risk (HR)-HPV in cervical lesions. Read More

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http://dx.doi.org/10.3892/ol.2020.11634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286137PMC

Cervical carcinoma in the setting of uterovaginal prolapse: comparing standard versus tailored management.

Ecancermedicalscience 2020 13;14:1043. Epub 2020 May 13.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA.

Objectives: Cervical cancer in the setting of uterovaginal prolapse is exceedingly rare. Altered anatomy can complicate treatment of underlying cancer. We first present a rare case of cervical cancer with invasion of uterovaginal prolapse as well as a systematic review of similar reported cases in the literature. Read More

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http://dx.doi.org/10.3332/ecancer.2020.1043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289612PMC

Biocurcumin as Radiosensitiser for Cervical Cancer Study (BRACES): A Double-Blind Randomised Placebo-Controlled Trial.

Evid Based Complement Alternat Med 2020 28;2020:1986793. Epub 2020 May 28.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Cervical cancer is a leading cause of death among women worldwide, particularly in Indonesia. The main treatment of advanced-stage cervical cancer is radiation; however, the outcomes do not meet the required expectations. [1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5dione] has been reported in several studies for its potency in cancer therapy. Read More

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http://dx.doi.org/10.1155/2020/1986793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275233PMC

Fertility preservation in women with early-stage gynecologic cancer: optimizing oncologic and reproductive outcomes.

Int J Gynecol Cancer 2020 Jun 21. Epub 2020 Jun 21.

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Baylor College of Medicine, Houston, TX, United States

Almost all standard therapies for gynecologic cancer, including surgical intervention, gonadotoxic chemotherapy, and radiation therapy, threaten a woman's childbearing potential. Preservation of fertility should be discussed with premenopausal women with early-stage gynecologic cancer shortly after diagnosis and, for women who desire to preserve fertility, during treatment planning. Many authors have investigated both oncologic and reproductive outcomes following fertility-sparing therapy, and there is ongoing development of assisted reproduction techniques available to cancer patients and survivors. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001328DOI Listing

Improving the Prognostic Performance of SUV in F-Fluorodeoxyglucose Positron-Emission Tomography/Computed Tomography Using Tumor-to-Liver and Tumor-to-Blood Standard Uptake Ratio for Locally Advanced Cervical Cancer Treated with Concurrent Chemoradiotherapy.

J Clin Med 2020 Jun 16;9(6). Epub 2020 Jun 16.

Department of Obstetrics and Gynecology, School of Medicine, Kyungpook National University, Daegu 41944, Korea.

Objective: We sought to evaluate whether the F-fluorodeoxyglucose uptake normalization of the primary tumor to both the liver and blood pool and lymph nodes to both the liver and blood pool can enhance the discrimination for prognosis prediction in patients with cervical cancer.

Methods: A total of 156 patients with cervical cancer (International Federation of Gynecology and Obstetrics stages IIB-IV) treated with concurrent chemoradiotherapy (CCRT) were enrolled. The maximum standardized uptake value (SUV) of tumor (tSUV) and the lymph node (nSUV) divided by the SUV of the liver (tumor-to-liver ratio (TLR) and node-to-liver (NLR)) and blood pool (tumor-to-blood ratio (TBR) and node-to-blood ratio (NBR)) were investigated. Read More

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http://dx.doi.org/10.3390/jcm9061878DOI Listing

Long non-coding RNA in cervical cancer: From biology to therapeutic opportunity.

Biomed Pharmacother 2020 Jul 20;127:110209. Epub 2020 May 20.

Department of Obstetrics and Gynecology, The Second Clinical Hospital of Jilin University, Changchun, China. Electronic address:

Genome regions that do not for code for proteins are generally transcribed into long non-coding RNAs. Growing evidence reveals that lncRNAs, defined as transcripts longer than 200 nucleotides, are commonly deregulated in cervical malignancies. New sequencing technologies have revealed a complete picture of the composition of the human transcriptome. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110209DOI Listing

Two ways of epigenetic silencing of TFPI2 in cervical cancer.

PLoS One 2020 19;15(6):e0234873. Epub 2020 Jun 19.

1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.

Objective: Comparison of human mRNA microarray results from tumor-associated and normal cervical fibroblasts revealed significant TFPI2 downregulation in tumor-associated fibroblasts isolated from cervical cancer, indicating that TFPI2 downregulation may play an important role in the pathogenesis of the disease. In the present work, we investigated the mechanism of TFPI2 downregulation in tumor-associated fibroblasts and tumor cells.

Methods: In vitro models of monocultures and co-cultures were established with tumor cells and fibroblasts to explore the changes of TFPI-2 expression and epigenetic modifications of the TFPI2 gene. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234873PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304613PMC

Angiopoietin-1 is associated with a decreased risk of lymph node metastasis in early stage cervical cancer.

Histol Histopathol 2020 Jun 17:18234. Epub 2020 Jun 17.

Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China.

Objectives: Lymph node metastasis (LNM) is an important determinant of prognosis in patients with cervical cancer. Members of the angiopoietin family have been demonstrated to regulate tumor-associated angiogenesis and lymphangiogenesis. This study aimed to investigate the expression levels of angiopoietin-1 (ANG1) and angiopoietin-2 (ANG2) in clinically early stage of cervical cancer along with their correlations with LNM. Read More

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http://dx.doi.org/10.14670/HH-18-234DOI Listing

The disease stage-associated imbalance of Th1/Th2 and Th17/Treg in uterine cervical cancer patients and their recovery with the reduction of tumor burden.

BMC Womens Health 2020 Jun 17;20(1):126. Epub 2020 Jun 17.

Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.

Background: Nearly all uterine cervical cancer (UCC) cases result from human papillomavirus (HPV) infection. After high-risk HPV infection, most HPV infections are naturally cleared by humoral and cell-mediated immune responses. Thus, cervical lesions of only few patients progress into cervical cancer via cervical intraepithelial neoplasia (CIN) and lead to persistent oncogenic HPV infection. Read More

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http://dx.doi.org/10.1186/s12905-020-00972-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301485PMC

'Secondary prevention' against female HPV infection: literature review of the role of carrageenan.

Expert Rev Anti Infect Ther 2020 Jun 19:1-10. Epub 2020 Jun 19.

Obstetrics and Gynecology, Villa Sofia Cervello Hospital, University of Palermo , Palermo, Italy.

Introduction: Human papillomaviruses (HPVs) are common sexually transmitted pathogens, causally associated with cervical cancer and other anogenital cancers, as well as approximately 20% of head and neck cancers. The HPV vaccine is an exceptional primary prevention tool, but the question of adequate secondary-prevention strategies remains open. The aim of this review is to better clarify the role of carrageenan in HPV prevention-strategies. Read More

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http://dx.doi.org/10.1080/14787210.2020.1770082DOI Listing

Multimodality Imaging of Uterine Cervical Malignancies.

AJR Am J Roentgenol 2020 Jun 17:1-13. Epub 2020 Jun 17.

Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390.

In this article, we provide an updated review on the role of imaging in initial staging, treatment monitoring, and follow-up of cervical cancer with a focus on the role of MRI and FDG PET/CT. In addition, the 2018 International Federation of Gynecology and Obstetrics staging system and its implication on management of cervical cancer are explored. Imaging plays a major role in treatment planning and as a prognostic indicator in patients with cervical cancer. Read More

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http://dx.doi.org/10.2214/AJR.19.21941DOI Listing

FABP5 promotes lymph node metastasis in cervical cancer by reprogramming fatty acid metabolism.

Theranostics 2020 17;10(15):6561-6580. Epub 2020 May 17.

Department of Obstetrics and Gynecology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong, China.

Patients with cervical cancer (CCa) with lymph node metastasis (LNM) have an extremely poor prognosis. Elucidation of the molecular mechanisms underlying LNM may provide clinical therapeutic strategies for CCa. Upregulation of fatty acid-binding protein 5 (FABP5) expression in CCa tumours was demonstrated to positively correlate with LNM. Read More

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http://dx.doi.org/10.7150/thno.44868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295046PMC

Combination Vaccination With Tetanus Toxoid and Enhanced Tumor-Cell Based Vaccine Against Cervical Cancer in a Mouse Model.

Front Immunol 2020 27;11:927. Epub 2020 May 27.

Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Cervical cancer is the fourth most common cancer in women with an estimated 570,000 new cases in 2018 which constitute about 6. 6% of all cancers in women according to WHO report 2018. Approximately 90% of the 270,000 deaths from cervical cancer in 2015 occurred in low- and middle-income countries. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269150PMC

The relationships of genetic polymorphisms of the long noncoding RNA growth arrest-specific transcript 5 with uterine cervical cancer.

Int J Med Sci 2020 18;17(9):1187-1195. Epub 2020 May 18.

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.

The purposes of the investigation were to examine the implications of long noncoding RNA growth arrest-specific transcript 5 (GAS5) in progression and clinicopathological factors of uterine cervical cancer, and patient survival in Taiwan. Genotypic distributions of two GAS5 genetic variants rs145204276 and rs55829688 were detected in 208 patients including 111 patients with invasive cancer, 97 with precancerous lesions as well as 307 control women using real-time polymerase chain reaction. It explored that patients with cervical precancerous lesion had lower rate of AGGCA deletion (Del) in both alleles (Del/Del) of GAS5 rs145204276 as compared with control women. Read More

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http://dx.doi.org/10.7150/ijms.44583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294910PMC

MiR-1193 Inhibits the Malignancy of Cervical Cancer Cells by Targeting Claudin 7 (CLDN7).

Onco Targets Ther 2020 19;13:4349-4358. Epub 2020 May 19.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Fujian Medical University, Fujian 350005, People's Republic of China.

Objective: MicroRNAs (miRNAs) are highly involved in cancer development, including in cervical cancer (CC). In this study, we aimed to investigate the role and possible mechanism of a poorly studied miRNA, miR-1193, in CC progression.

Materials And Methods: Expression of miR-1193 was determined in 60 pairs of cervical samples. Read More

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http://dx.doi.org/10.2147/OTT.S247115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245469PMC

Prediction scoring system based on clinicohematologic parameters for cervical cancer patients undergoing chemoradiation.

Int J Gynecol Cancer 2020 Jun 16. Epub 2020 Jun 16.

Department of Radiation Oncology, Gachon University Gil Medical Center, Incheon, Republic of Korea

Objective: A scoring system based on clinicohematologic parameters in cervical cancer patients receiving chemoradiation has not been reported to date. The aim of this study was to determine the prognostic value of clinicohematologic parameters in patients with cervical cancer undergoing chemoradiation and to develop a prediction scoring system based on these results.

Methods: A total of 107 patients who received definitive chemoradiation for cervical cancer were enrolled in this study. Read More

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http://dx.doi.org/10.1136/ijgc-2019-001050DOI Listing

Expression and prognosis of CyclinA and CDK2 in patients with advanced cervical cancer after chemotherapy.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 5;66(3):85-91. Epub 2020 Jun 5.

Department of Gynecology, Zaozhuang Municipal Hospital, Zaozhuang, 277100, China.

This study aimed to investigate the expression and prognosis of CyclinA and CDK2 in patients with advanced cervical cancer after chemotherapy. The patient history of 108 patients with advanced cervical cancer admitted to our hospital from December 2013 to January 2016 was selected as a cervical cancer group. 54 normal healthy people admitted to our hospital for physical examination in the same period were selected as the control group. Read More

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Trends in guideline-adherent fertility-sparing surgery for early-stage cervical cancer before and after the Affordable Care Act.

Gynecol Oncol 2020 Jun 11. Epub 2020 Jun 11.

The George Washington University Medicine and Health Sciences, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington, D.C., United States of America.

Objective: To assess trends in guideline-adherent fertility-sparing surgery (GA-FSS) for early-stage cervical cancer relative to Patient Protection and Affordable Care Act (ACA) implementation.

Methods: National Cancer Database patients treated for Stage IA1-IB1 cervical cancer from 2004 to 2016 were included. Multivariable logistic regression was used to determined trends in GA-FSS relative to the ACA and identify patient factors independently associated with GA-FSS. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.05.027DOI Listing

The outcomes and quality of life of young patients undergoing adjuvant radiotherapy versus non-radiotherapy following surgery treating early FIGO stage cervical squamous cell cancer in southwestern China.

Sci Rep 2020 Jun 12;10(1):9583. Epub 2020 Jun 12.

Department of Obstetrics and Gynecology, West China Second University Hospital, Chengdu, China.

Background: The incidence of cervical cancer in young women is rising, and squamous cell carcinoma makes up a great percentage of the histological types. The presence of aggressive pathologic risk factors following patients' primary surgery may warrant the use of adjuvant radiotherapy. It is important to weigh up the risks and benefits of using adjuvant radiotherapy for each young patient so as to maximize their prognosis while minimizing the treatment-related morbidity. Read More

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http://dx.doi.org/10.1038/s41598-020-66661-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293287PMC

Aldolase A promotes epithelial-mesenchymal transition to increase malignant potentials of cervical adenocarcinoma.

Cancer Sci 2020 Jun 12. Epub 2020 Jun 12.

Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Recent studies have revealed that metabolic reprogramming is closely associated with epithelial-mesenchymal transition (EMT) during cancer progression. Aldolase A (ALDOA) is a key glycolytic enzyme that is highly expressed in several types of cancer. In this study, we found that ALDOA is highly expressed in uterine cervical adenocarcinoma and that high ALDOA expression promotes EMT to increase malignant potentials, such as metastasis and invasiveness, in cervical adenocarcinoma cells. Read More

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http://dx.doi.org/10.1111/cas.14524DOI Listing

Comprehensive analysis of prognostic alternative splicing signature in cervical cancer.

Cancer Cell Int 2020 8;20:221. Epub 2020 Jun 8.

Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 China.

Background: Alternative splicing (AS) is a key factor in protein-coding gene diversity, and is associated with the development and progression of malignant tumours. However, the role of AS in cervical cancer is unclear.

Methods: The AS data for cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) were downloaded from The Cancer Genome Atlas (TCGA) SpliceSeq website. Read More

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http://dx.doi.org/10.1186/s12935-020-01299-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282181PMC
June 2020
1.989 Impact Factor

Long-term outcomes of intensity-modulated radiation therapy (IMRT) and high dose rate brachytherapy as adjuvant therapy after radical hysterectomy for cervical cancer.

Int J Gynecol Cancer 2020 Jun 11. Epub 2020 Jun 11.

Radiation Oncology, Washington University School of Medicine, St Louis, Missouri, USA

Objective: Compared with 3D-planned pelvic radiation, intensity-modulated radiation therapy (IMRT) has been shown to reduce acute toxicity in cervical cancer patients after radical hysterectomy. This study evaluated late toxicity and patterns of failure after post-operative pelvic IMRT interdigitated weekly with high dose rate brachytherapy.

Methods: This retrospective study included 53 cervical cancer patients treated between January 2006 and August 2019 with radical hysterectomy, lymphadenectomy, and post-operative IMRT and high dose rate brachytherapy. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001412DOI Listing

MicroRNA-96-5p Facilitates the Viability, Migration, and Invasion and Suppresses the Apoptosis of Cervical Cancer Cells byNegatively Modulating SFRP4.

Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820934132

Department of Obstetrics and Gynecology, Laishan Branch of Yantai Yuhuangding Hospital, Laishan District, Yantai City, Shandong Province, China.

Purpose: The current study was intended to research the functional role and regulatory mechanism of microRNA-96-5p in the progression of cervical cancer.

Methods: MicroRNA-96-5p expression in cervical cancer tissues was assessed by quantitative real-time polymerase chain reaction. The association between microRNA-96-5p expression and clinicopathological features of patients with cervical cancer was analyzed. Read More

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http://dx.doi.org/10.1177/1533033820934132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294480PMC

Fertility- and nerve-sparing laparoscopic eradication of deep endometriosis with total posterior compartment peritonectomy: the Kurashiki method.

J Minim Invasive Gynecol 2020 Jun 8. Epub 2020 Jun 8.

Department of Obstetrics and Gynecology, Kurashiki Medical Center, Okayama, Japan.

Objective: To show technical highlights of a nerve-sparing laparoscopic eradication of deep endometriosis (DE) with posterior compartment peritonectomy.

Design: Demonstration of the technique with narrated video footage.

Setting: An urban general hospital. Read More

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http://dx.doi.org/10.1016/j.jmig.2020.05.028DOI Listing

Survival After Minimally Invasive vs Open Radical Hysterectomy for Early-Stage Cervical Cancer: A Systematic Review and Meta-analysis.

JAMA Oncol 2020 Jun 11. Epub 2020 Jun 11.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York.

Importance: Minimally invasive techniques are increasingly common in cancer surgery. A recent randomized clinical trial has brought into question the safety of minimally invasive radical hysterectomy for cervical cancer.

Objective: To quantify the risk of recurrence and death associated with minimally invasive vs open radical hysterectomy for early-stage cervical cancer reported in observational studies optimized to control for confounding. Read More

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http://dx.doi.org/10.1001/jamaoncol.2020.1694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290695PMC

Small-Cell Carcinoma of the Uterine Cervix Discovered With Quadriplegia Caused by Cervical Spine Metastasis.

Clin Med Insights Case Rep 2020 7;13:1179547620920170. Epub 2020 May 7.

Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan.

Small-cell carcinoma of the uterine cervix is a rare and aggressive tumor, and the prognosis is poor compared with those of squamous cell carcinoma and adenocarcinoma of the uterine cervix, even when discovered at an earlier stage. We treated a patient with progressive small-cell carcinoma of the uterine cervix that metastasized to the cervical spine. The patient, a 73-year-old woman, presented with the symptom of numbness in her limbs. Read More

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http://dx.doi.org/10.1177/1179547620920170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236087PMC

Prognostic Factors and Local Treatment Modalities of Small-Cell Carcinoma of the Cervix: An Analysis According to the International Federation of Gynecology and Obstetrics Stage.

Cancer Manag Res 2020 14;12:3445-3456. Epub 2020 May 14.

Department of Obstetrics and Gynecology, The Shanghai East Hospital, Shanghai 200120, People's Republic of China.

Purpose: Small-cell carcinoma of the cervix (SCCC) is a rare type of cervical cancer. This study aimed to investigate the clinicopathological characteristics and survival as well as the optimal local treatment modalities for SCCC.

Patients And Methods: We retrospectively evaluated the data of patients diagnosed with SCCC between 1988 and 2015 in our institution - those included in the Surveillance, Epidemiology, and End Results (SEER) database and those in the Periodical Database. Read More

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http://dx.doi.org/10.2147/CMAR.S247081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236046PMC

Leonurine Promotes Cisplatin Sensitivity in Human Cervical Cancer Cells Through Increasing Apoptosis and Inhibiting Drug-Resistant Proteins.

Drug Des Devel Ther 2020 15;14:1885-1895. Epub 2020 May 15.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, People's Republic of China.

Background: Cisplatin-based neoadjuvant chemotherapy and concurrent radiotherapy and chemotherapy are the main treatment for advanced cervical cancer. However, the development of multidrug resistance (MDR) leads to chemotherapy failure, tumor recurrence and poor survival. In this research, we investigated the effect and corresponding mechanism of leonurine on cisplatin sensitivity of cervical cancer cells. Read More

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http://dx.doi.org/10.2147/DDDT.S252112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237110PMC

Tailored radical hysterectomy for locally advanced cervical cancer.

Int J Gynecol Cancer 2020 Jun 9. Epub 2020 Jun 9.

Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Objective: The survival and prognostic factors for locally advanced cervical cancer treated with nerve-sparing Okabayashi-Kobayashi radical hysterectomy have not been elucidated. We aimed to evaluate the oncological outcomes of those patients after radical hysterectomy with adjuvant chemotherapy.

Methods: This retrospective cohort study was conducted from January 2002 to December 2011. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001387DOI Listing

Special Ambulatory Gynecologic Considerations in the Era of COVID-19 and Implications for Future Practice.

Am J Obstet Gynecol 2020 Jun 6. Epub 2020 Jun 6.

Johns Hopkins University School of Medicine, Department of Gynecology and Obstetrics; Johns Hopkins HIV Women's Health Program.

The COVID-19 pandemic has altered medical practice in unprecedented ways. While much of the emphasis in obstetrics and gynecology to date has been on the as yet uncertain impacts of COVID-19 in pregnancy and on changes to surgical management, the pandemic has broad implications for ambulatory gynecologic care as well. In this article we review important ambulatory gynecologic topics including safety and metal health, reproductive life planning, sexually transmitted infections, and routine screening for breast and cervical cancer. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.06.006DOI Listing

Dioscorea nipponica Makino suppresses TPA-induced migration and invasion through inhibition of matrix metalloproteinase-9 in human cervical cancer cells.

Environ Toxicol 2020 Jun 10. Epub 2020 Jun 10.

School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Dioscorea nipponica Makino has been used for the treatment of chronic bronchitis, rheumatoid arthritis, cough, and asthma. Several studies have established the antitumor effect of D. nipponica Makino extract (DNE). Read More

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http://dx.doi.org/10.1002/tox.22984DOI Listing

Expression of immune cell markers and tumor markers in patients with cervical cancer.

Int J Gynecol Cancer 2020 Jun 8. Epub 2020 Jun 8.

Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China

Objective: Cervical cancer is one of the most common cancers worldwide, and immune function may impact disease progression. Serum markers may also be associated with diagnosis and progression. The aim of this study was to explore the clinical usefulness of determining the levels of peripheral blood immune cells and serum tumor markers in predicting diagnosis and prognosis of patients with cervical cancer. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001254DOI Listing