6,401 results match your criteria Cervical Cancer* Obstetrics and Gynecology


The association between metformin therapy and risk of gynecological cancer in patients: Two meta-analyses.

Eur J Obstet Gynecol Reprod Biol 2019 Apr 15;237:33-41. Epub 2019 Apr 15.

Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu, China. Electronic address:

Background: Recently, metformin, first-line drug for type 2 diabetes, has been reported to treat some gynecological tumors. However, these epidemiological studies have never been formally summarized. Considering a single study may lack the power to provide reliable conclusion, we performed two meta-analyses with different indicators to assess metformin's role in reducing the risk of gynecological cancers. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.03.029DOI Listing

A GCIG international survey: clinical practice patterns of sentinel lymph node biopsies in cervical cancer.

Arch Gynecol Obstet 2019 Apr 21. Epub 2019 Apr 21.

Department of Gynecology With Center for Oncological Surgery, Charité Universtitätmedizin, Charité Platz 1, 10117, Berlin, Germany.

Purpose: To evaluate the practice patterns among centers and physicians worldwide regarding sentinel lymph node biopsies (SLNB) in cervical cancer (CC) patients.

Method: A validated 35-item questionnaire regarding SLNB in CC supported by the Gynecologic Cancer Intergroup (GCIG), and sponsored by the North-Eastern German Society of Gynaecologic-Oncology (NOGGO) was sent to all major gynecological cancer societies across the globe for further distribution from October 2015 and continued for a period of 7 months.

Results: One hundred and sixty-one institutions from around the world participated. Read More

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http://link.springer.com/10.1007/s00404-019-05164-2
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http://dx.doi.org/10.1007/s00404-019-05164-2DOI Listing
April 2019
1 Read

Chrysin Inhibits Proinflammatory Factor-Induced EMT Phenotype and Cancer Stem Cell-Like Features in HeLa Cells by Blocking the NF-κB/Twist Axis.

Cell Physiol Biochem 2019 ;52(5):1236-1250

Department of Gynecology and Obstetrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China,

Background/aims: TNF-α and TGF-β associated epithelial-mesenchymal transition (EMT) occurs via NF-κB-dependent transcriptional upregulation of Twist1.Chrysin (ChR) is a major active ingredient ofpropolis, which inhibits various cancer cells and possesses anti-inflammatory activities. This study aimed to assess whether and how ChR inhibits proinflammatory cytokine-induced EMT phenotype and cancer stem-like cell (CSLC) features in the HeLa cell line. Read More

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https://www.cellphysiolbiochem.com/Articles/000084/
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http://dx.doi.org/10.33594/000000084DOI Listing
January 2019
1 Read

Analysis of preventability of malignancy related maternal death from the nationwide registration syste19m of maternal deaths in Japan.

J Matern Fetal Neonatal Med 2019 Apr 18:1-191. Epub 2019 Apr 18.

b Department of Obstetrics and Gynecology , Mie University School of Medicine , Mie , Japan.

Objective: We reviewed malignancy related maternal deaths in Japan to ascertain if there were avoidable factors.

Methods: Malignancy related maternal death in Japan reported to the Maternal Death Exploratory Committee, from 2010 to 2016 inclusive.

Results: There were 12 cases of maternal death caused by malignancy. Read More

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http://dx.doi.org/10.1080/14767058.2019.1609930DOI Listing

Comparison of urine, self-collected vaginal swab, and cervical swab samples for detecting human papillomavirus (HPV) with Roche Cobas HPV, Anyplex II HPV, and RealTime HR-S HPV assay.

J Virol Methods 2019 Apr 15;269:77-82. Epub 2019 Apr 15.

Department of Obstetrics and Gynecology, Korea University Guro Hospital, College of Medicine, Korea University, Seoul, Republic of Korea. Electronic address:

Background: Human papillomavirus (HPV) is well established as the main cause of cervical cancer. Non-invasive self-collected urine and vaginal sampling have the potential advantage of increasing patient compliance with cervical cancer screening.

Methods: Self-collected vaginal and urine samples and clinician-collected cervical samples were collected from 101 patients, including 84 patients with high grade squamous intraepithelial lesion and 17 patients with benign ovarian disease. Read More

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http://dx.doi.org/10.1016/j.jviromet.2019.04.012DOI Listing
April 2019
1 Read

Pathway to the Papanicolaou smear: The development of cervical cytology in twentieth-century America and implications in the present day.

Gynecol Oncol 2019 Apr 14. Epub 2019 Apr 14.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, United States of America.

George Papanicolaou, a Greek immigrant and cytopathologist, was responsible for what is now colloquially known as the "Pap smear"-undoubtedly one of the greatest advances in medicine and public health of the last century. However, his landmark research on the development of cervical cytology for the detection of precancerous lesions of the cervix ("New Cancer Diagnosis," 1928) made a rather inauspicious debut in an unlikely venue: John Harvey Kellogg's Third Race Betterment Conference-a meeting devoted to the furtherance of the concept and implementation of eugenics. Herein, we discuss the stark juxtaposition of Papanicolaou's landmark discovery amid the pseudoscience of the third Race Betterment Conference. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.04.004DOI Listing
April 2019
1 Read

Whole-Genome Analysis of Human Papillomavirus Type 16 Prevalent in Japanese Women with or without Cervical Lesions.

Viruses 2019 Apr 16;11(4). Epub 2019 Apr 16.

Pathogen Genomics Center, National Institute of Infectious Diseases, Musashi-murayama, Tokyo 208-0011, Japan.

Recent large-scale genomics studies of human papillomaviruses (HPVs) have shown a high level of genomic variability of HPV16, the most prevalent genotype in HPV-associated malignancies, and provided new insights into the biological and clinical relevance of its genetic variations in cervical cancer development. Here, we performed deep sequencing analyses of the viral genome to explore genetic variations of HPV16 that are prevalent in Japan. A total of 100 complete genome sequences of HPV16 were determined from cervical specimens collected from Japanese women with cervical intraepithelial neoplasia and invasive cervical cancer, or without cervical malignancies. Read More

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https://www.mdpi.com/1999-4915/11/4/350
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http://dx.doi.org/10.3390/v11040350DOI Listing
April 2019
3 Reads

Cancer-derived exosomal miR-221-3p promotes angiogenesis by targeting THBS2 in cervical squamous cell carcinoma.

Angiogenesis 2019 Apr 15. Epub 2019 Apr 15.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Guangzhou Medical University, 510120, Guangzhou, China.

Aims: Recently, cancer-derived exosomes were shown to have pro-metastasis function in cancer, but the mechanism remains unclear. Angiogenesis is essential for tumor progression and is a great promising therapeutic target for advanced cervical cancer. Here, we investigated the role of cervical cancer cell-secreted exosomal miR-221-3p in tumor angiogenesis. Read More

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http://link.springer.com/10.1007/s10456-019-09665-1
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http://dx.doi.org/10.1007/s10456-019-09665-1DOI Listing
April 2019
7 Reads
4.876 Impact Factor

A Comparative Study for Selectivity of Micronuclei in Cervical Exfoliated Cells on Chronic Boron Effects.

J Cytol 2019 Apr-Jun;36(2):75-78

Department of Medical Biology, School of Medicine, Faculty of Health Sciences, Manisa Celal Bayar University, Manisa, Turkey.

Background: Cervical cancer is one of the most frequent malignancies in women. Micronucleus (MN) testing has gained popularity as a biomarker in early diagnosis of many types of cancer.

Aims: This study aims to investigate the role of MN testing on early detection of cervical cancer and the effect of boron exposure on cervical cells. Read More

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http://dx.doi.org/10.4103/JOC.JOC_185_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425774PMC
April 2019
1 Read

Downregulation of microRNA-425-5p suppresses cervical cancer tumorigenesis by targeting AIFM1.

Exp Ther Med 2019 May 18;17(5):4032-4038. Epub 2019 Mar 18.

Department of Gynecology and Obstetrics, Shijiazhuang Obstetrics and Gynecology Hospital, Shijiazhuang, Hebei 050011, P.R. China.

Although microRNA-425-5p (miR-425-5p) has been previously revealed to be upregulated in cervical cancer, the cellular function of miR-425-5p in cervical cancer remains unknown. The aim of the current study was to investigate the cellular function of miR-425-5p and its underlying mechanism in cervical cancer. Reverse transcription-quantitative polymerase chain reaction was used to measure miR-425-5p expression in several cervical cancer cell lines. Read More

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http://dx.doi.org/10.3892/etm.2019.7408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447898PMC
May 2019
1 Read

Anticancer activity of bergenin against cervical cancer cells involves apoptosis, cell cycle arrest, inhibition of cell migration and the STAT3 signalling pathway.

Exp Ther Med 2019 May 13;17(5):3525-3529. Epub 2019 Mar 13.

Department of Radiation Oncology, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, Guangdong 510095, P.R. China.

Bergenin is a secondary metabolite that may be primarily isolated from species. Although it has been found to exhibit significant biological activities, the anticancer activity of bergenin against cervical cancer cells has not been explored. The present study was designed to evaluate the anticancer effects of bergenin on HeLa cervical cancer cells. Read More

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http://dx.doi.org/10.3892/etm.2019.7380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447771PMC
May 2019
1 Read

Reduction of cervical cancer incidence within a primary HPV screening pilot project (WOLPHSCREEN) in Wolfsburg, Germany.

Br J Cancer 2019 Apr 16. Epub 2019 Apr 16.

Department of Obstetrics and Gynecology, Klinikum Wolfsburg, Wolfsburg, Germany.

Background: Randomised controlled trials showed human papillomavirus (HPV)-based screening leads to a significant reduction in cervical cancer incidence compared with cytology-based screening only.

Methods: Non-hysterectomised participants ≥30 years underwent co-testing with Papanicolaou (Pap) smear and HR-HPV testing (Hybrid Capture 2; HC2). Women with normal findings had their next screening round after 5 years, and HC2+ and Pap abnormal cases were immediately referred for colposcopy, while cases with discordant findings had repeat testing after 12 months with referral to colposcopy in cases with persistent positive findings. Read More

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http://www.nature.com/articles/s41416-019-0453-2
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http://dx.doi.org/10.1038/s41416-019-0453-2DOI Listing
April 2019
2 Reads

Nine-valent HPV vaccine efficacy against related diseases and definitive therapy: comparison with historic placebo population.

Gynecol Oncol 2019 Apr 11. Epub 2019 Apr 11.

Merck & Co., Inc., Kenilworth, NJ, United States. Electronic address:

Objective: Nine-valent human papillomavirus (9vHPV) vaccine efficacy against disease and cervical surgeries related to all nine vaccine components was assessed compared with a historic placebo population. This was not assessed in the 9vHPV vaccine efficacy trial since the trial was quadrivalent HPV (qHPV) vaccine-controlled, efficacy was measured for the five HPV types covered only by 9vHPV vaccine (HPV31/33/45/52/58), but not the four types covered by both vaccines (HPV6/11/16/18).

Methods: Three international, randomized, double-blind studies were conducted using the same methodology. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.03.253DOI Listing
April 2019
1 Read

Prognostic value of ADC quantification for clinical outcome in uterine cervical cancer treated with concurrent chemoradiotherapy.

Eur Radiol 2019 Apr 12. Epub 2019 Apr 12.

Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Objectives: To investigate the prognostic value of diffusion-weighted imaging (DWI) in predicting clinical outcome in patients with cervical cancer after concurrent chemoradiotherapy (CCRT).

Methods: We enrolled 124 cervical cancer patients who received definitive CCRT and underwent 3 T-MRI before and 1 month after initiating treatment. The mean apparent diffusion coefficient (ADC) value was measured on the tumor and the changes in ADC percentage (ΔADC) between the two time points were calculated. Read More

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http://dx.doi.org/10.1007/s00330-019-06204-wDOI Listing
April 2019
1 Read
4.014 Impact Factor

Octamer binding transcription factor-4 expression is associated with cervical cancer malignancy and histological differentiation: A systematic review and meta-analysis.

Biosci Rep 2019 Apr 12. Epub 2019 Apr 12.

Department of Gastroenterology, Taihe Hospital, Shiyan, Washington, 442012, China

Objective: The relationship between the expression of octamer binding transcription factor 4  (OCT-4) and clinicopathological features of cervical cancer (CC) is evaluated in detail.

Methods: The findings on the relationship collected by retrieving PubMed, EMBASE, Cochrane library, Wan Fang and Chinese National Knowledge Infrastructure(CNKI) databases results and tracing back to the literature and published in public, which began in setting up the literature database and ended in May 2018. The literatures are screened, extracted and evaluated according to the inclusion and exclusion criteria, and meta-analysis was carried out via RevMan 5. Read More

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http://bioscirep.org/lookup/doi/10.1042/BSR20182328
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http://dx.doi.org/10.1042/BSR20182328DOI Listing
April 2019
2 Reads

Cervical cancer screening among women living with HIV: a cross-sectional study using the baseline questionnaire data from the Canadian HIV Women's Sexual and Reproductive Health Cohort Study (CHIWOS).

CMAJ Open 2019 Apr-Jun;7(2):E217-E226. Epub 2019 Apr 12.

Chronic Viral Illness Service (de Pokomandy, Bakombo, Proulx-Boucher), McGill University Health Centre; Department of Family Medicine (de Pokomandy, O'Brien), McGill University, Montréal, Que.; Department of Family and Community Medicine (Burchell), St. Michael's Hospital; Department of Family and Community Medicine (Burchell), University of Toronto, Toronto, Ont.; Faculty of Health Sciences (Salters, Kaida), Simon Fraser University, Burnaby, BC; BC Centre for Excellence in HIV/AIDS (Salters, Ding, Kaida), Vancouver, BC; Department of Obstetrics and Gynecology (Boucoiran), Hôpital Sainte-Justine and Université de Montréal, Montréal, Que.; Oak Tree Clinic (Pick), BC Women's Hospital; Department of Family Practice (Ogilvie), School of Population and Public Health, University of British Columbia, Vancouver, BC; Women's College Research Institute (Loutfy), Women's College Hospital; Faculty of Medicine (Loutfy), University of Toronto, Toronto, Ont.

Background: Cisgender women with HIV experience an elevated risk of cervical cancer compared with HIV-negative women, but this cancer can be prevented through regular cervical cancer screening. Our study objective was to measure adherence to current national cervical cancer screening guidelines among women with HIV in 3 Canadian provinces and identify factors associated with delays.

Methods: We conducted a cross-sectional study using the baseline questionnaire of the Canadian HIV Women's Sexual and Reproductive Health Cohort Study (CHIWOS). Read More

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http://dx.doi.org/10.9778/cmajo.20180151DOI Listing

Development and evaluation of a cervical cancer screening system in Cambodia: A collaborative project of the Cambodian Society of Gynecology and Obstetrics and Japan Society of Obstetrics and Gynecology.

J Obstet Gynaecol Res 2019 Apr 11. Epub 2019 Apr 11.

Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan.

Aim: In Cambodia, the Japan Society of Obstetrics and Gynecology and the Cambodian Society of Gynecology and Obstetrics have an on-going project, started in 2015, for cervical cancer prevention and treatment. The project, currently aimed at factory workers, includes a women's health education program that leads into cervical cancer prevention by establishment of a system for early detection and treatment. It begins by health education, screening for human papillomavirus (HPV), followed by colposcopy and quicker treatment of earlier precursor lesions. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jog.13968
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http://dx.doi.org/10.1111/jog.13968DOI Listing
April 2019
3 Reads

Fibronectin promotes cervical cancer tumorigenesis through activating FAK signaling pathway.

J Cell Biochem 2019 Apr 11. Epub 2019 Apr 11.

Department of Obstetrics and Gynecology, Suzhou Traditional Chinese and Western Medicine Hospital, Suzhou, China.

Cervical cancer is a cancer arising from the cervix, and it is the fourth most common cause of death in women. Overexpression of fibronectin 1 (FN1) was observed in many tumors and associated with the survival and metastasis of cancer cells. However, the mechanism by which FN1 promotes cervical cancer cell viability, migration, adhesion, and invasion, and inhibits cell apoptosis through focal adhesion kinase (FAK) signaling pathway remains to be investigated. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28282
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http://dx.doi.org/10.1002/jcb.28282DOI Listing
April 2019
8 Reads

[TGF-β1 activates NOX4/ROS pathway to promote the invasion and migration of cervical cancer cells].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2019 Feb;35(2):121-127

Anhui Clinical and Preclinical Key Laboratory of Respiratory Disease, First Affiliated Hospital, Bengbu Medical College, Bengbu 233004, China. *Corresponding author, E-mail:

Objective To investigate the role of transforming growth factor β1/nicinamide adenine dinucleotide phosphate oxidase/reactive oxygen species (TGF-β1/NOX4/ROS) signaling pathway in the invasion and migration of cervical cancer cells. Methods The cultured SiHa, CaSki, HeLa, C4-I and C33A cervical cancer cells were treated with 5 ng/mL TGF-β1 for 4 hours or 8 hours. ROS levels in these cervical cancer cells were detected using 2', 7'-dichlorofluorescein diacetate (DCFH-DA) staining combined with flow cytometry. Read More

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February 2019
6 Reads

ΔNp63 to TAp63 expression ratio as a potential molecular marker for cervical cancer prognosis.

PLoS One 2019 11;14(4):e0214867. Epub 2019 Apr 11.

Department of Biomedical Laboratory Science, Yonsei University, Wonju-si, Gangwon-do, Republic of Korea.

p63 is a transcription factor p53 family. Two major isoforms of p63, TAp63 with transactivation (TA) domain and ΔNp63 with truncated TA domain, have been reported to play opposing roles either in tumor suppression or oncogenic function. Little is known about the association of these two isoforms of p63 in the carcinogenesis of cervical cancer. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214867PLOS
April 2019
5 Reads

Tablet-Based Patient Education Regarding Human Papillomavirus Vaccination in Colposcopy Clinic.

J Low Genit Tract Dis 2019 Apr 8. Epub 2019 Apr 8.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, MA.

Objective: The aim of this study was to use an electronic tablet-based education module to increase patient knowledge about human papillomavirus (HPV).

Methods: Patients presenting to an academic colposcopy clinic were first queried as to whether they had been infected with HPV. A quality improvement project was then conducted using a 4-question pretest assessing baseline knowledge about HPV and cancer, followed by a tablet-based education module and a 5-question posttest. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000474DOI Listing
April 2019
4 Reads

The expression and significance of lncRNA HOST2 and microRNA let-7b in HPV-positive cervical cancer tissues and cell lines.

Eur Rev Med Pharmacol Sci 2019 Mar;23(6):2380-2390

Department of Obstetrics and Gynecology, Hebei Medical University, Shijiazhuang, Hebei, China.

Objective: This study attempted to investigate the expression and significance of lncRNA HOST2 (human ovarian cancer-specific transcript 2) and microRNA let-7b in human papillomavirus (HPV)-positive cervical cancer (CC) tissues and cell lines.

Patients And Methods: The expression of levels of HOST2 and let-7b were detected by qRT-PCR in HPV-positive CC tissues and cell lines. The HPV-positive CaSki and HeLa cells were divided into the Blank, NC, pcDNA3. Read More

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http://dx.doi.org/10.26355/eurrev_201903_17384DOI Listing
March 2019
1 Read

LncRNA AB073614 promotes the proliferation and inhibits apoptosis of cervical cancer cells by repressing RBM5.

Eur Rev Med Pharmacol Sci 2019 Mar;23(6):2374-2379

Department of Obstetrics and Gynecology, Hanchuan People's Hospital, Hanchuan, China.

Objective: Recent studies have determined the crucial role of long noncoding RNAs (lncRNAs) in cancer development. Cervical cancer (CC) is a common type of fatal gynecological cancer worldwide. This study aims to identify the role of lncRNA AB073614 in the progression of CC. Read More

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http://dx.doi.org/10.26355/eurrev_201903_17382DOI Listing

HPV73 a non-vaccine type causes cervical cancer.

Int J Cancer 2019 Apr 9. Epub 2019 Apr 9.

Department of Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Ave, Ullmann Building, Room 515, Bronx 10461, New York, USA.

HPV73 is classified as possibly oncogenic. It is neither routinely evaluated in HPV screening, nor covered by any of the prophylactic vaccines. We sought to investigate the carcinogenic characteristics of HPV73. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32315
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http://dx.doi.org/10.1002/ijc.32315DOI Listing
April 2019
2 Reads

CDK7 inhibitor suppresses tumor progression through blocking the cell cycle at the G2/M phase and inhibiting transcriptional activity in cervical cancer.

Onco Targets Ther 2019 22;12:2137-2147. Epub 2019 Mar 22.

Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, People's Republic of China,

Background: The disordered cell cycle and dysregulated expression of numerous oncogenes involved in tumor-relevant processes are highly related to the tumorigenesis of cervical cancer. Cyclin-dependent kinase 7 (CDK7) constitutes the indispensable catalytic subunit of CDK-activating kinase (CAK), which is required for both cell cycle transition and transcriptional regulation. However, research regarding the antitumor effects of CDK7 inhibition in cervical cancer remains unclear. Read More

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http://dx.doi.org/10.2147/OTT.S195655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434917PMC
March 2019
1.342 Impact Factor

Estrogen stimulates female cancer progression by inducing myeloid-derived suppressive cells: investigations on pregnant and non-pregnant experimental models.

Oncotarget 2019 Mar 8;10(20):1887-1902. Epub 2019 Mar 8.

Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan.

Objective: To investigate the clinical implications of 17β-estradiol (E2) in estrogen receptor α (ERα)-negative female cancer progression as well as the underlying biological mechanisms.

Methods: Clinical data from 306 locally-advanced cervical cancer (stage IIB-IVA) patients were analyzed in order to investigate the relationships between age, serum E2 levels, and treatment outcomes. Clinical samples, ERα-negative cervical and breast cancer cell lines, and mouse xenograft models of cervical and breast cancers were employed in order to elucidate the mechanisms responsible for the E2- and pregnancy-mediated progression of cervical and breast cancers, with a focus on the role of myeloid-derived suppressor cells (MDSC). Read More

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http://dx.doi.org/10.18632/oncotarget.26711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443012PMC
March 2019
2 Reads

The efficacy and safety of Tipapkinogen Sovacivec therapeutic HPV vaccine in cervical intraepithelial neoplasia grades 2 and 3: Randomized controlled phase II trial with 2.5 years of follow-up.

Gynecol Oncol 2019 Apr 2. Epub 2019 Apr 2.

Roche Pharmaceutical Research & Early Development, Roche Innovation Center New York, 430 E. 29th Street New York City, New York 10016, USA. Electronic address:

Background: While prophylactic human papillomavirus (HPV) vaccination exists, women are still developing cervical intraepithelial neoplasia (CIN) grade 2 or 3 for which an immunotherapeutic, non-surgical, approach may be effective. The primary aim was to assess the efficacy of tipapkinogen sovacivec (TS) vaccine in achieving histologic resolution of CIN2/3 associated with high risk (HR) HPV types.

Methods: Women 18 years and older who had confirmed CIN2/3 were enrolled in a randomized, double blind, placebo-controlled phase II trial and assigned to drug in a 2:1 ratio (vaccine:placebo). Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.03.250DOI Listing
April 2019
1 Read

Tumor-targeting Salmonella typhimurium A1-R overcomes nab-paclitaxel resistance in a cervical cancer PDOX mouse model.

Arch Gynecol Obstet 2019 Apr 5. Epub 2019 Apr 5.

AntiCancer Inc., San Diego, CA, USA.

Purpose: Cervical cancer is a recalcitrant disease. To help overcome this problem, we previously established a patient-derived orthotopic xenograft (PDOX) model of cervical cancer. In the previous study, we found the tumor to be resistant to nab-paclitaxal (nab-PTX). Read More

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http://dx.doi.org/10.1007/s00404-019-05147-3DOI Listing
April 2019
4 Reads

[Association of EGFR gene G719S and T790M mutations with cervical cancer].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2019 Apr;36(4):376-379

Institute of Pharmacy and Pharmacology, Hunan Provincial Cooperative Innovation Center for Molecular Target New Drug Research, University of South China, Hengyang, Hunan 421001, China. Email:

Objective: To establish a rapid and accurate "on/off" switch technique consisted of 3'-phosphorothioate-modified allele-specific primers and exo+ polymerase to screen the G719S and T790M mutations of epidermal growth factor receptor (EGFR) gene. The switch was used to identify cervical cancer patients who are sensitive to tyrosine kinase inhibitor (TKI).

Methods: Allele-specific primers targeting recombinant wild-type and mutation-type templates were designed with 3' terminal phosphorothioate modification. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2019.04.021DOI Listing
April 2019
10 Reads

Working together to eliminate cervical cancer: a partnership across three countries "As mudanças no mundo são criadas por nós".

Int J Gynecol Cancer 2019 Apr 3. Epub 2019 Apr 3.

Department of Gynecologic Oncology & Reproductive Medicine, MD Anderson Cancer Center, Houston, Texas, USA

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http://dx.doi.org/10.1136/ijgc-2019-000372DOI Listing
April 2019
3 Reads

Plasma CADM1 promoter hypermethylation and D-dimer as novel metastasis predictors of cervical cancer.

J Obstet Gynaecol Res 2019 Apr 3. Epub 2019 Apr 3.

Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Aim: Cervical cancer (CC) is the fourth malignant tumor in women worldwide. The metastasis is still the major reason for the treatment failures of most CC patients. Cell adhesion molecule 1 (CADM1) promoter methylation and plasma D-dimer levels have been reported to be increased in many types of cancers. Read More

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http://dx.doi.org/10.1111/jog.13966DOI Listing
April 2019
2 Reads

Unlocking the therapeutic potential of primary tumor-draining lymph nodes.

Cancer Immunol Immunother 2019 Apr 3. Epub 2019 Apr 3.

Department of Medical Oncology, Amsterdam UMC, Cancer Center Amsterdam, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

Lymph nodes draining the primary tumor are essential for the initiation of an effective anti-tumor T-cell immune response. However, cancer-derived immune suppressive factors render the tumor-draining lymph nodes (TDLN) immune compromised, enabling tumors to invade and metastasize. Unraveling the different mechanisms underlying this immune escape will inform therapeutic intervention strategies to halt tumor spread in early clinical stages. Read More

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http://dx.doi.org/10.1007/s00262-019-02330-yDOI Listing
April 2019
1 Read

The Increased PTK7 Expression Is a Malignant Factor in Cervical Cancer.

Dis Markers 2019 3;2019:5380197. Epub 2019 Mar 3.

Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, No. 154, Anshan Road, He Ping District, Tianjin 300052, China.

Cervical cancer is one of the most common malignant neoplasms in gynecology. Protein tyrosine kinase 7 (PTK7) with an inactive kinase domain is an important regulator of multiple Wnt pathways under normal and various pathological conditions and overexpressed in various tumors; however, the clinical and biological significance of PTK7 in cervical cancer is still unknown. In the present study, the protein expression level of PTK7 was detected in clinical cervical cancer patient samples, and the relationship between PTK7 expression and clinicopathological features was analyzed. Read More

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http://dx.doi.org/10.1155/2019/5380197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421733PMC
March 2019
5 Reads

Optimal subset of signature miRNAs consisting of 7 miRNAs that can serve as a novel diagnostic and prognostic predictor for the progression of cervical cancer.

Oncol Rep 2019 Apr 3. Epub 2019 Apr 3.

Department of Obstetrics and Gynecology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huaiyin, Huai'an, Jiangsu 223300, P.R. China.

Cervical cancer is the second most commonly diagnosed cancer in women. Novel prognostic biomarkers are required to predict the progression of cervical cancer. Cervical cancer expression data were obtained from The Cancer Genome Atlas (TCGA) database. Read More

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http://dx.doi.org/10.3892/or.2019.7097DOI Listing
April 2019
1 Read
2.191 Impact Factor

Transgelin 2 overexpression inhibits cervical cancer cell invasion and migration.

Mol Med Rep 2019 Apr 3. Epub 2019 Apr 3.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China.

Cervical cancer is a malignancy that threatens female health. The present study aimed to investigate the role of transgelin 2 (TAGLN2) in cervical cancer. Reverse transcription‑quantitative polymerase chain reaction and western blotting were conducted to detect the mRNA and protein expression levels of particular factors in HeLa cells. Read More

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http://dx.doi.org/10.3892/mmr.2019.10116DOI Listing
April 2019
3 Reads

Regulatory mechanisms of fluvastatin and lovastatin for the p21 induction in human cervical cancer HeLa cells.

PLoS One 2019 2;14(4):e0214408. Epub 2019 Apr 2.

Department of Biochemistry, National Defense Medical Center, Taipei City, Taiwan, Republic of China.

p21, an inhibitor of cyclin-dependent kinase, functions as an oncogene or tumor suppressor depending on the context of a variety of extracellular and intracellular signals. The expression of p21 could be regulated at the transcriptional and/or post-translational levels. The p21 gene is well-known to be regulated in both p53-dependent and -independent manners. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214408PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445431PMC
April 2019
1 Read

Cervical Cancer Screening Access, Outcomes, and Prevalence of Dysplasia in Correctional Facilities: A Systematic Review.

J Womens Health (Larchmt) 2019 Apr 2. Epub 2019 Apr 2.

1 Department of Obstetrics and Gynecology, Women and Infants Hospital and the Warren Alpert Medical School of Brown University, Providence, Rhode Island.

Background: Incarcerated women often access health care primarily through contact with correctional systems. Cervical cancer screening within the correctional system can address the preventable outcome of cervical dysplasia and cancer in this high-risk population.

Materials And Methods: A search of PubMed, EMBASE, CINAHL, and ClinicalTrials. Read More

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http://dx.doi.org/10.1089/jwh.2018.7440DOI Listing
April 2019
1 Read

Could interleukin-33 and its suppressor of tumorigenicity 2 (ST2) receptor have a role in cervical human papillomavirus (HPV) infections?

Gynecol Endocrinol 2019 Apr 2:1-7. Epub 2019 Apr 2.

a Department of Obstetrics and Gynecology , Faculty of Medicine, Erzincan University , Erzincan , Turkey.

Why most women can clear human papillomavirus (HPV) infections while others can develop permanent infections. The stimulation of immunotolerance of the immune system of the host by the persistent HPV infection may be the answer to this question. Interleukin-33 (IL-33) may play a role in the pathogenesis of HPV infection, this hypothesis was thought to be due to the rapid release of IL-33 from damaged cells following tissue damage, necrosis, and activation of the inflammasome. Read More

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https://www.tandfonline.com/doi/full/10.1080/09513590.2019.1
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http://dx.doi.org/10.1080/09513590.2019.1590699DOI Listing
April 2019
24 Reads

Involvement of NEAT1/miR-133a axis in promoting cervical cancer progression via targeting SOX4.

J Cell Physiol 2019 Apr 1. Epub 2019 Apr 1.

Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.

NEAT1 is an important tumor oncogenic gene in various tumors. Nevertheless, its involvement remains poorly studied in cervical cancer. Our study explored the functional mechanism of NEAT1 in cervical cancer. Read More

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http://dx.doi.org/10.1002/jcp.28538DOI Listing
April 2019
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Melatonin enhances TNF-α-mediated cervical cancer HeLa cells death via suppressing CaMKII/Parkin/mitophagy axis.

Cancer Cell Int 2019 14;19:58. Epub 2019 Mar 14.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Zhengzhou University, No.2 Jinba Road, Zhengzhou, 450014 China.

Background: Tumor necrosis factor-α (TNF-α) immunotherapy controls the progression of human cervical cancer. Here, we explored the detailed molecular mechanisms played by melatonin in human cervical cancer (HeLa cells) death in the presence of TNF-α injury, with a particular attention to the mitochondrial homeostasis.

Methods: HeLa cells were incubated with TNFα and then cell death was determined via MTT assay, TUNEL staining, caspase ELISA assay and western blotting. Read More

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http://dx.doi.org/10.1186/s12935-019-0777-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419493PMC
March 2019
1 Read

Extraperitoneal radical trachelectomy with pelvic lymphadenectomy.

Int J Gynecol Cancer 2019 Mar 26. Epub 2019 Mar 26.

Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Japan

Radical trachelectomy combined with pelvic lymphadenectomy has been used to treat patients with early-stage cervical cancer who wish to preserve their fertility. Vaginal, abdominal, laparoscopic, and robotic approaches have been employed during this procedure, but all cause peritoneal damage, which could result in periadnexal adhesion. As periadnexal adhesion can lead to female infertility due to restricted sweeping of the fimbria over the ovary, it is important to minimize peritoneal damage during the fertility-preserving surgery. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000196DOI Listing
March 2019
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[FABP5 promotes cell growth, invasion and metastasis in cervical cancer].

Zhonghua Zhong Liu Za Zhi 2019 Mar;41(3):200-207

Department of Obstetrics and Gynecology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510700, China.

To investigate the functions of FABP5 in the carcinogenesis and development of cervical cancer. The expression of FABP5 was detected in several cervical cancer cell lines (C33A, Siha, Caski, HeLa and HCC94), 206 cases of cervical cancer tissues with stage Ⅰa2-Ⅱa2 and 40 cases of normal cervical tissues by real-time PCR and Western blotting. Then, the cells were infected with lentivirus-mediated siRNA-targeting FABP5. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.03.009DOI Listing
March 2019
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Pretreatment Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) as a Predictive Value of Hematological Markers in Cervical Cancer

Asian Pac J Cancer Prev 2019 Mar 26;20(3):863-868. Epub 2019 Mar 26.

International Program of Medicine, Taipei Medical University, Taipei, Taiwan.

Background: Inflammation represents a pivotal role in the progression of cervical cancer. The hematological markers of inflammation in complete blood count (CBC) panel are potentially useful in determining the prognosis of the disease. Objective: The aim of the study was to investigate whether the pretreatment neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) could be used as in predicting the stage of cervical cancer. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.3.863DOI Listing
March 2019
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Long noncoding RNA SOX21-AS1 promotes cervical cancer progression by competitively sponging miR-7/VDAC1.

J Cell Physiol 2019 Mar 25. Epub 2019 Mar 25.

Department of Obstetrics and Gynecology, the first Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Growing evidence has shown that long noncoding RNAs (lncRNAs) play crucial roles in cervical cancer. Dy000sregulation of lncRNA SOX21 antisense RNA 1 (SOX21-AS1) has been reported in several tumors. However, its expression pattern and potential biological function in cervical cancer (CC) have not been investigated. Read More

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http://dx.doi.org/10.1002/jcp.28371DOI Listing

Predictive factors of severe perioperative morbidity of radical hysterectomy with lymphadenectomy in early-stage cervical cancer: A French prospective multicentric cohort of 248 patients.

Eur J Surg Oncol 2019 04 17;45(4):650-658. Epub 2018 Oct 17.

Gynecologic and Breast Oncologic Surgery Department, Georges Pompidou European, Hospital, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.

Objective: The purpose of this study was to assess the postoperative morbidity after radical hysterectomy (RH) for early-stage cervical cancer and to determine risk factors of severe perioperative morbidity.

Methods: Data of two prospective trials on sentinel node biopsy for cervical cancer (SENTICOL I & II) were analysed. Patients having a radical hysterectomy were included between 2005 and 2012 from 25 French oncologic centers. Read More

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http://dx.doi.org/10.1016/j.ejso.2018.10.057DOI Listing
April 2019
2 Reads

Histopathology of Women with “Atypical Squamous Cells Cannot Exclude High-Grade Squamous Intraepithelial Lesion” (ASC-H) Smears

Asian Pac J Cancer Prev 2019 Mar 26;20(3):683-686. Epub 2019 Mar 26.

Department of Obstetrics and Gynecology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Objectives: To evaluate prevalence of underlying significant pathologies among women with cervical smears rated as ‘atypical squamous cells cannot exclude high grade squamous intraepithelial lesion (ASC-H)’, as well as associated risk factors. Methods: Medical records were reviewed of all consecutive women with ASC-H smears who had undergone colposcopy at Srinagarind Hospital from January 2008 to July 2016. Significant pathology results included cervical intraepithelial neoplasia (CIN) 2-3, adenocarcinoma in situ (AIS), endometrial hyperplasia, and cancer of any original site. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.3.683DOI Listing
March 2019
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Long non-coding RNA activated by transforming growth factor-β promotes proliferation and invasion of cervical cancer cells by regulating the miR-144/ITGA6 axis.

Exp Physiol 2019 Mar 25. Epub 2019 Mar 25.

Department of Obstetrics, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.

New Findings: What is the central question of this study? This study was designed to investigate the molecular mechanism and biological roles of long non-coding RNA activated by transforming growth factor-β (lncRNA ATB) in the progression of cervical cancer. What is the main finding and its importance? Our study provided new insight into the cross-talk between lncRNA ATB, miR-144 and ITGA6, shedding light on the therapy for cervical cancer.

Abstract: The present study was designed to investigate the molecular mechanism and biological roles of long non-coding RNA activated by transforming growth factor-β (lncRNA ATB) in the progression of cervical cancer. Read More

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http://dx.doi.org/10.1113/EP087656DOI Listing
March 2019
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Evaluating the Effectiveness of Interventions on Increasing Participation in Cervical Cancer Screening.

J Nurs Res 2019 Mar 21. Epub 2019 Mar 21.

PhD, RN, Professor, Department of Obstetrics and Gynecology Nursing, School of Nursing, Koc University, Istanbul, Turkey.

Background: Although cervical cancer is highly preventable through regular screenings using Pap smear or human papillomavirus-deoxyribonucleic acid tests, cervical cancer remains a prevalent women's health issue across the world. Therefore, encouraging women to screen for cervical cancer is very important for the early detection of cervical cancer.

Purpose: The purposes of this study were to (1) assess the effectiveness of three interventions that are typically used to increase the uptake of cervical cancer screening during home visits and (2) determine the participation rate in cervical cancer screenings after invitation, the health promotion perceptions, and the cervical cancer and screening-related knowledge of women. Read More

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http://dx.doi.org/10.1097/jnr.0000000000000317DOI Listing
March 2019
6 Reads

Guidelines for Cervical Cancer Screening in Immunosuppressed Women Without HIV Infection.

J Low Genit Tract Dis 2019 Apr;23(2):87-101

Department of Obstetrics and Gynecology, University of Oklahoma Tulsa, OU-TU School of Community Medicine, Tulsa, OK.

Executive Summary: The risk of cervical cancer (CC) among women immunosuppressed for a variety of reasons is well documented in the literature. Although there is improved organ function, quality of life and life expectancy gained through use of immunosuppressant therapy, there may be increased long-term risk of cervical neoplasia and cancer and the need for more intense screening, surveillance, and management. Although guidance for CC screening among HIV-infected women (see Table 1) has been supported by evidence from retrospective and prospective studies, recommendations for CC screening among non-HIV immunosuppressed women remains limited because quality evidence is lacking. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000468DOI Listing
April 2019
2 Reads

Clinical outcomes after isolated pelvic failure in cervical cancer patients treated with definitive radiation.

Gynecol Oncol 2019 Mar 21. Epub 2019 Mar 21.

Department of Radiation Oncology, Washington University School of Medicine, United States of America. Electronic address:

Purpose: To describe clinical outcomes in patients with isolated pelvic failures after definitive radiation treatment for cervical cancer.

Methods And Materials: Cervical cancer patients with isolated pelvic failure after definitive radiation with brachytherapy boost were identified in a tertiary academic center database from 1997 to 2016. All patients received an FDG-PET scan prior to their initial treatment and at the time of their first recurrence. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.03.104DOI Listing
March 2019
2 Reads